US6385358B1 - Birefringence insensitive optical coherence domain reflectometry system - Google Patents
Birefringence insensitive optical coherence domain reflectometry system Download PDFInfo
- Publication number
- US6385358B1 US6385358B1 US09/479,674 US47967400A US6385358B1 US 6385358 B1 US6385358 B1 US 6385358B1 US 47967400 A US47967400 A US 47967400A US 6385358 B1 US6385358 B1 US 6385358B1
- Authority
- US
- United States
- Prior art keywords
- arm
- light
- recited
- fiber
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00174—Optical arrangements characterised by the viewing angles
- A61B1/00177—Optical arrangements characterised by the viewing angles for 90 degrees side-viewing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00174—Optical arrangements characterised by the viewing angles
- A61B1/00181—Optical arrangements characterised by the viewing angles for multiple fixed viewing angles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
Definitions
- This invention relates to a birefringence insensitive fiber optic optical coherence domain reflectometry (OCDR) system.
- the system is designed to provide a disposable section of non-polarization maintaining optical fiber in the sample arm while achieving high resolution by matching the dispersion between the sample arm and the reference arm.
- Optical coherence domain reflectometry is a technique developed by Youngquist et al. in 1987 (Youngquist et al., “Optical Coherence-Domain Reflectometry: A New Optical Evaluation Technique”, 1987 , Optics Letters 12(3):158-160).
- OCT optical coherence tomography
- OCDR and OCT have been applied to imaging and diagnoses of biological tissues, such as dental tissue (See U.S. Pat. No. 5,570,182 to Nathel et al.).
- OCT systems have been miniaturized to enable their use with guidewires.
- OCDR and guidewire systems are disclosed in WO 99/02113 (PCT/US98/14499) to Winston et al. and U.S. patent application Ser. No. 09/050,571 to Everett et al.
- FIG. 1 A diagram of a prior art OCDR scanning system is shown in FIG. 1 .
- Light from a low coherence source 10 is input into a 2 ⁇ 2 fiber optic coupler 12 , where the light is split and directed into a sample arm 14 and a reference arm 16 .
- An optical fiber 18 in the sample arm 14 extends into a device 20 that scans an object 22 .
- the reference arm 16 provides a variable optical delay.
- Light input into the reference arm 16 is reflected bade by a reference mirror 24 .
- a piezoelectric modulator 26 may be included in the reference arm 16 with a fixed reference mirror 24 , or the modulator 26 may be eliminated by scanning the mirror 24 in the Z-direction.
- the reflected reference beam from reference arm 16 and the scattered sample beam from sample arm 14 pass back through the coupler 12 to detector 28 (including processing electronics), which processes the signals by techniques that are known in the art to produce a backscatter profile or image on a display unit 30 .
- Standard fiber optic OCDR systems currently use non-polarization maintaining (non-PM.) fiber throughout, leading to loss of signal and to artifacts associated with mismatches between the polarization states of the light from the reference and sample arms (polarization fading). These mismatches are caused by birefringence in the sample and reference arms and the sample itself.
- non-PM. non-polarization maintaining
- the polarization state of the light in the reference arm 46 is modified by either a waveplate or a faraday rotator 48 so as to be equally split between the two modes (orthogonal polarizations) of the PM fiber upon reflection.
- a polarization beam splitter 50 in the detector arm 52 splits the two polarization modes and directs them to two separate detectors 54 , 56 connected to the image processing and display unit 58 .
- the multiplexed optical fibers 60 in the sample arm 62 are polarization maintaining (PM).
- the sample arm 62 contains a multiplexer 66 for switching between the plurality of fibers 60 , allowing sequential spatially distinct regions to be observed consecutively using the OCDR system.
- the fibers 60 can be oriented such that the light leaving the fibers is linearly polarized at an angle approximately 45° relative to the fast axis of birefringence of the sample 64 .
- a quarter waveplate can be placed at the distal end of each fiber 60 to cause the light entering the sample 64 to be circularly polarized.
- processing and display unit 58 includes means for ratioing the output signals from detectors 54 , 56 ; the birefringence of the sample 64 is determined based on the arc tangent of the ratio of the signals from the two detectors 54 , 56 .
- the optical fibers 60 in the sample arm 62 are not polarization maintaining (non-PM).
- the polarization beam splitter 50 ensures that the polarization state of the light from the reference arm 46 and the sample arm 62 is matched on each detector 54 , 56 , thus eliminating the losses due to depolarization of the light.
- the light returning from the sample arm 62 is then measured by summing the signals from the two detectors 54 , 56 .
- the present invention addresses the above-mentioned problems and significantly improves on the system described in U.S. patent application Ser. No. 09/050,571 by providing a design for a less expensive, more robust, birefringence insensitive OCDR system that accommodates a disposable non-PM fiber in the sample arm, yet eliminates dispersion issues.
- the object of the present invention is to provide a birefringence insensitive fiber optic optical coherence domain reflectometry (OCDR) system containing non-polarization maintaining (non-PM) fiber in the sample arm. Birefringence insensitive systems eliminate signal degradation caused by birefringence. Another object of the present invention is to minimize mismatches in dispersion between the sample and reference arms, while maintaining a disposable section of non-PM fiber in the sample arm. This is accomplished through the use of matching non-PM fiber in the reference arm. A further object of the invention is to provide a portable, robust OCDR system that can be used in medical applications or for non-medical in situ probes. A further object of the invention is to provide a means of incorporating a single mode fiber optical path modulator in the system for providing optical path scanning. A further object of the invention is to provide a means for more efficiently coupling of optical power to and from the sample arm.
- OCDR birefringence insensitive fiber optic optical coherence domain reflectometry
- the disposable portion of non-PM optical fiber in the sample arm is useful for incorporation into various clinical devices such as catheters, guidewires, and hand-held instruments or probes.
- the use of non-PM fiber significantly reduces the cost of these devices.
- Disposable sections of non-PM fiber can be incorporated into both the sample arm and the reference arm to permit convenient replacement of fibers used on patients or to rapidly configure OCDR systems with different path lengths.
- OCDR systems particularly in medical applications, require a portion of the sample arm that is either disposable or multiplexed.
- the use of polarization maintaining (PM) fiber throughout the OCDR system in conjunction with a polarization diversity receiver is beneficial from the standpoint of eliminating signal fading associated with birefringence.
- the use of non-PM fiber in the disposable or multiplexed portion of the sample arm is preferable due to its significantly reduced cost.
- the use of non-PM fiber in the sample arm with PM fiber in the reference arm causes the OCDR system to suffer loss of resolution due to mismatches in dispersion between the two arms.
- an additional faraday rotator which rotates the polarization of light by approximately 45° upon double passing is placed between the PM and non-PM fiber in the reference arm.
- This faraday rotator causes the returning light from the reference arm, which was initially in a single polarization mode of the PM fiber, to be split between the two polarization modes.
- the polarization diversity receiver then consists of two or more detectors, which detect light in each of the two polarization modes of the fiber.
- essentially all or all fiber used in the reference arm and the sample arm is non-PM fiber.
- a polarization diversity receiver collects the light in each of two orthogonal polarization modes. This design is significantly less expensive, but suffers from polarization drift in the source and detector arm optical fibers, which are not double passed. This can be minimized by using optical fibers that are as short as possible.
- the detector arm and source arm of the system can be combined to form a more efficient system.
- use of coupler which couples more than 50% of the light from the source/detector arm to the sample arm and back can increase the sensitivity of the system.
- Use of a 90/10 coupler in this system would allow up to 81% of the light from the source to interact with the sample and return versus a maximum of 25% obtained with a 50/50 coupler if the source and detector are in separate arms.
- the combination source/detector arm contains a plurality of beamsplitters and detectors to collect the light.
- the present invention is useful for medical applications, particularly in ophthalmology, dentistry, and cardiology, as it eliminates birefringence effects in both the tissue sample and fiber optics. Birefringence in biological tissues, such as the eye or dental tissue, leads to artifacts in images with conventional OCT systems. Artifacts and signal fading associated with birefringence in optical fibers is also a serious problem in clinical systems, particularly in catheter or guidewire based OCDR imaging systems. The catheter or guidewire in these systems must be replaced for each patient.
- the present invention provides the ability to incorporate non-PM optical fiber in those systems to significantly lower costs and facilitate the replacement of portions of the sample arm, while eliminating artifacts and signal losses due to polarization fading.
- the present invention can also be used in non-medical applications where the fiber or probe in the sample arm becomes damaged or contaminated by the sample being imaged, and thus the fiber must be replaced repeatedly.
- the use of non-PM fiber in such systems is therefore advantageous and cost-effective.
- the invention can be used as a single point probe to examine defects in fiber optics, for example, or the sample arm can be scanned to form two-dimensional images or depth-resolved images.
- FIG. 1 shows a prior art OCDR system.
- FIG. 2 shows an OCDR guidewire optical sensing system with multiplexed sample arm using polarized light.
- FIG. 3 shows an OCDR system according to the present invention.
- FIG. 4 shows an alternative embodiment of the OCDR system according to the present invention.
- FIG. 5 shows an alternative embodiment of the OCDR system according to the present invention in which the source arm and detector arm are integrated.
- the present invention is a birefringence insensitive fiber optic optical coherence domain reflectometry (OCDR) system that contains non-polarization maintaining (non-PM) optical fiber in the sample arm and the reference arm without suffering from signal degradation caused by birefringence.
- OCDR birefringence insensitive fiber optic optical coherence domain reflectometry
- non-PM non-polarization maintaining optical fiber
- a section of non-PM fiber can be replaceable or multiplexed.
- the use of non-PM optical fiber significantly reduces the cost of the OCDR system.
- the invention provides a portable, robust OCDR system that can be used in medical applications or for non-medical in situ probes.
- PM fiber has two principal orthogonal axes: a fast axis having the lower index of refraction and a slow axis having the higher index of refraction.
- FIG. 3 is a diagram of an OCDR system according to the present invention.
- the source arm 70 introduces linearly polarized light into the system either through a linearly polarized broadband light source 72 or by placing a linear polarizer 74 directly after an unpolarized source 72 .
- the light source 72 (and polarizer 74 ) is coupled to an input PM fiber 76 .
- the linear polarization of the light is maintained through the use of the PM fiber 76 and a 2 ⁇ 2 PM fiber optic coupler 78 , where the linear polarization is one of the two modes (i.e., fast and slow axes) of the PM fiber 76 and PM coupler 78 .
- Output from the source 72 is split at the 2 ⁇ 2 fiber optic coupler 78 into two optical fiber outputs and directed through a sample arm 90 to a sample 92 and through a reference arm 80 to a reference mirror 82 . Reflections from the mirror 82 and reflected or backscattered light from the sample 92 are recombined at the coupler 78 and propagated to the detector arm 100 (and to source arm 70 ).
- the detector arm 100 includes a plurality of detectors 102 , 104 (typically two) with associated processing electronics that produce a backscatter profile on an image processing and display unit 106 by methods known in the art.
- the system can be used as a single-point probe; additionally, the unit 106 may provide means for generating cross-sectional images of the sample.
- Coherent interference creates a signal at the detectors 102 , 104 when the sample and reference reflections have traveled approximately the same optical group delay.
- a piezomodulator (not shown) to vary the path length of the reference arm 80
- a piezoelectric modulator can be alternatively or additionally placed in the sample arm 90 to increase the relative path variation between the reference arm 80 and the sample arm 90 , i.e., to vary the path length of the reference arm with respect to the path length of the sample arm.
- the polarization of the light through the OCDR system is controlled by PM optical fibers and optics.
- the polarized light entering the reference arm 80 travels through a length L 1 of PM fiber 86 and a length L 2 of non-PM fiber 88 .
- the polarization state of the light from the PM fiber 86 is modified by a polarization optical element 110 that rotates the polarization by approximately 22.5° before entering the non-PM fiber 88 , or 45° upon double passing through the reference arm 80 .
- a suitable optical element 110 is a 22.5° faraday rotator.
- the light from the non-PM fiber 88 is modified by a rotator optical element 84 that rotates the polarization by 45° before reflecting off the mirror 82 , or 90° upon double passing through the reference arm 80 .
- a suitable optical element 84 is a 45° faraday rotator.
- the polarization state of the light returning from the mirror 82 is modified (a second time) by the 45° faraday rotator 84 , passes through the non-PM fiber 88 , is modified (a second time) by the 22.5° faraday rotator 110 , and passes through the PM fiber 86 to the PM coupler 78 .
- the light passes from the coupler 78 into PM fiber 112 in the detector arm 100 . Since the 45° faraday rotator 84 eliminates the birefringence effects (or changes in birefringence) in the non-PM fiber 88 , the light entering the detector arm 100 from the reference arm 80 has a defined, or pre-determined, polarization state.
- the defined polarization state is independent of, or unaffected by, changes in birefringence in the non-PM fiber 88 in the reference arm 80 .
- the 22.5° faraday rotator 110 causes the light to be split equally into the two polarization modes of the PM fiber as it rotates the polarization of the light by a total of 45°. While a total rotation of 45° is optimal, any amount of total rotation other than 0° or 90° by faraday rotator 110 will couple light into the second orthogonal polarization mode of the fiber.
- An optical element 108 in the detector arm 100 splits the light from fiber 112 into the two orthogonal polarization modes and directs them to the detectors 102 , 104 connected to the image processing and display unit 106 .
- the polarization beam splitter 108 splits the light equally between the two detectors 102 , 104 .
- the polarized light entering the sample arm 90 travels through a length L 3 of PM fiber 94 , followed by a length L 4 of non-PM fiber 96 to the sample 92 .
- the PM fiber 94 and non-PM fiber 96 are spliced together or connected by other conventional means.
- the light reflected or scattered from the sample 92 passes back through the non-PM fiber 96 and PM fiber 94 to the PM coupler 78 and into PM fiber 112 in the detector arm 100 .
- the polarization beam splitter 108 in the detector arm 100 splits the polarization state of the light from the fiber 112 into two modes (orthogonal polarizations) and directs them to the detectors 102 , 104 connected to the image processing and display unit 106 .
- the total light in all polarization states returning from the sample 92 is determined by summing the envelope of the heterodyned signals from the two detectors 102 , 104 . If there were mismatched dispersion between the reference arm and sample arm, the two signals from the detectors would be broadened, decreasing the resolution of the system. Since the dispersion is matched in the reference arm and sample arm in the present invention, the signals are not broadened and thus high image resolution is achieved.
- the total optical path length L 5 of the reference arm 80 (i.e., from coupler 78 to mirror 82 ) is substantially equal to the total optical path length L 6 of the sample arm 90 (i.e., from coupler 78 to sample 92 ). Any combination of PM and non-PM fibers can be used as long as path lengths L 5 and L 6 are substantially equal.
- the lengths L 1 and L 3 of the PM fibers 86 , 94 are preferably of approximately equal length to match wavelength and polarization dispersion between the reference arm 80 and sample arm 90 .
- the lengths L 2 and LA of the non-PM fibers 88 , 96 in the reference arm 80 and sample arm 90 are also of approximately equal length.
- the fiber and path lengths L 1 -L 6 can be varied for different designs and applications of the OCDR system.
- a piezoelectric transducer PZT may be used to vary the path length in either or both the reference arm (L 5 ) and the sample arm (L 6 ) by wrapping the optical fiber around the transducer.
- a distal portion or section L 7 of the length L 4 of the non-PM fiber 96 that interacts with the sample 92 may be a replaceable or disposable section.
- This replaceable section L 7 may be connected to the remainder of the non-PM fiber 96 by a connector 114 .
- This approach is preferred for medical device applications, where the section of fiber interacting with a patient (or incorporated into a device such as a guidewire or probe) must be detachable and replaceable for hygienic reasons.
- the detached section may be disposable, or sterilized and reused in some cases.
- a corresponding section L 8 (of the length L 2 ) of the non-PM fiber 88 in the reference arm 80 that matches the length of the replaceable section L 7 of non-PM fiber 96 in the sample arm 90 can also be replaceable.
- This approach allows the length and dispersion characteristics of the disposable fiber in the sample arm 90 to be matched by a fiber in the reference arm 80 of appropriate length and dispersion characteristics.
- a device 98 may be attached to or placed at the distal end of the non-PM fiber 96 in the sample arm to better direct or focus the light on the sample 92 (e.g., on or in a patient) and to enhance light collection.
- the device 98 may include one or more optical devices, e.g., graded index (GRIN) lens, bulk optic lens, mirror, prism, or a wave plate.
- GRIN graded index
- a distal section of optic fiber may be incorporated into a device 98 such as a catheter, guidewire, probe, or other handheld instrument or handpiece.
- the device 98 may contain means to transversely scan light across the sample, which enables generation of cross-sectional images of the sample.
- the sample arm 90 contains a multiplexer or optical switch (such as element 66 shown in FIG. 2) for switching between a plurality of non-PM fibers, allowing sequential spatially distinct regions to be sampled consecutively using the OCDR system.
- a dispersion compensator 116 may be placed between the rotator element 84 and the reference mirror 82 to compensate for additional differences in dispersion between the sample and reference arms.
- the reference arm 80 can also include an attenuator 118 between the rotator element 84 and the reference mirror 82 to reduce the power returning to the detectors 102 , 104 from the reference arm 80 . If the optical power returning from the reference arm 80 is too large, then the sensitivity of the system may be reduced due to either saturation or optical source noise.
- FIG. 4 shows an alternative embodiment of a birefringence insensitive OCDR system according to the present invention using all or essentially all non-PM fiber.
- Linearly polarized light from a source 130 passes through non-PM fiber 120 and enters a non-PM coupler 132 , where the light is split and directed to the sample arm 140 and the reference arm 150 .
- the light in the reference arm 150 passes through non-PM fiber 152 followed by a 45° per pass faraday rotator 154 for a total of 90° rotation after reflection from the reference mirror 160 .
- the faraday rotator 154 cancels the birefringence from the non-PM fiber 152 , leading to linearly polarized light returning from the reference arm 150 to the coupler 132 .
- the coupler 132 may be a fiber optic non-PM coupler (e.g., 2 ⁇ 2) or may be replaced by a bulk optic beamsplitter.
- the reference arm 150 may include a dispersion compensator 156 and/or an attenuator 158 positioned after the non-PM fiber 152 .
- Non-PM fiber 142 including an optional disposable section
- the device 144 is such as described for FIG. 3 .
- the reflected light returning from the reference arm 150 and the sample arm 140 passes through the coupler 132 and fiber 122 into the detector arm 170 .
- the path lengths of the sample arm 140 and the reference arm 150 are approximately equal.
- the lengths of non-PM fibers 120 , 122 should be minimized to minimize bireftingence effects. If the coupler 132 is replaced by a bulk optic beamsplitter, then the non-PM fibers 120 , 122 can be eliminated.
- the detector arm 170 includes a polarization optic 172 aligned at 45° relative to the linearly polarized light returning from the reference arm 150 .
- the light entering the detector arm 170 from the reference arm 150 has a defined, or preselected, polarization state.
- the polarization optic 172 such as a polarization beam splitter, splits the light from the reference arm 150 equally into the two orthogonal modes, where each mode is detected by one of a plurality of detectors 174 , 176 (typically two, as shown).
- the detectors are connected to an image processing and display unit 178 to process the data and generate images using methods known in the art.
- This alternative approach shown in FIG. 4 is inexpensive, but has the drawback that if the coupler 132 is a fiber optic (2 ⁇ 2) coupler, the birefringence of the non-PM fiber in the coupler 132 and in the fiber 122 (between the coupler 132 and the polarization optic 172 in the detector arm 170 ) may drift slightly over time, causing the relative amplitude of the light in the two polarization modes to drift.
- the optical fiber 120 , 122 in the source arm and/or the detector arm 170 can be bent until the polarization state of the light is split equally between the two polarization modes.
- the bent fiber can be held in the desired position by a fixture that permits subsequent adjustment or repositioning.
- the use of a bulk optic beamsplitter in place of the coupler 132 also eliminates this problem.
- FIG. 5 shows another alternative embodiment that uses all or essentially all non-PM fiber throughout the system.
- the detector arm is incorporated into the source arm 180 through the use of a specialized optical isolator 186 , which comprises multiple optical elements and directs light from an unpolarized source 182 to a coupler 184 , while redirecting light returning from the coupler 184 .
- the optical isolator 186 collects all the light returning to the source arm 180 and redirects it, splitting the orthogonal polarization states between a plurality of detectors, typically two detectors 188 , 190 as shown.
- a polarizer 192 polarizes the light from the source 182 .
- This polarized light then passes through a 45° faraday rotator 194 , optionally followed by a half wave-plate 196 , to a second polarizer 198 , which is orientated so as to pass all the light making it through polarizer 192 .
- the half wave-plate 196 can be used between the polarizers 192 , 198 so as to rotate the linearly polarized light and allow more freedom in the orientation of polarizer 198 .
- a 22.5° faraday rotator 200 is placed immediately after polarizer 198 . Light leaving the source arm 180 is linearly polarized after leaving polarizer 198 .
- the 22.5° faraday rotator 200 is used to split the light from the reference arm 202 between the two polarization states, and the 45° faraday rotator 206 is used at the end of the reference arm 202 to eliminate non-PM birefringence effects in the reference arm 202 .
- the 22.5° faraday rotator 200 splits the light from the reference arm 202 equally between the two polarization states.
- a Faraday rotator 200 which rotates the polarization state by an angle other than 22.5° can also be used, resulting in differing amounts of light from the reference arm being coupled into each of the polarization states. Differing light levels from the reference arm on the two detectors makes it more difficult to operate both detectors at optimum power levels.
- Light returning from the sample arm 212 is split in an arbitrary manner between the detectors 188 , 190 based on its polarization state. Once again, the envelope of the heterodyne signals from the detectors 188 , 190 are summed to determine the amount of light returning from the sample arm 212 .
- An advantage of this system is that a large fraction of the initial light can be coupled through the coupler 184 and back, through the use of a non 50/50 coupler. For example, a 90/10 coupler could be used to transfer 90% of the light from the source arm 180 to the sample arm 212 , and 90% of the light from the sample arm 212 back to the source arm 180 .
- a bulk optic beamsplitter can be used in place of the coupler 184 , eliminating the use of optical fiber 204 .
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Optics & Photonics (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
Description
Claims (48)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/479,674 US6385358B1 (en) | 1998-03-30 | 2000-01-07 | Birefringence insensitive optical coherence domain reflectometry system |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/050,571 US6175669B1 (en) | 1998-03-30 | 1998-03-30 | Optical coherence domain reflectometry guidewire |
US09/479,674 US6385358B1 (en) | 1998-03-30 | 2000-01-07 | Birefringence insensitive optical coherence domain reflectometry system |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/050,571 Continuation-In-Part US6175669B1 (en) | 1998-03-30 | 1998-03-30 | Optical coherence domain reflectometry guidewire |
Publications (1)
Publication Number | Publication Date |
---|---|
US6385358B1 true US6385358B1 (en) | 2002-05-07 |
Family
ID=21966024
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/050,571 Expired - Fee Related US6175669B1 (en) | 1998-03-30 | 1998-03-30 | Optical coherence domain reflectometry guidewire |
US09/479,674 Expired - Lifetime US6385358B1 (en) | 1998-03-30 | 2000-01-07 | Birefringence insensitive optical coherence domain reflectometry system |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/050,571 Expired - Fee Related US6175669B1 (en) | 1998-03-30 | 1998-03-30 | Optical coherence domain reflectometry guidewire |
Country Status (3)
Country | Link |
---|---|
US (2) | US6175669B1 (en) |
AU (1) | AU3120099A (en) |
WO (1) | WO1999049780A1 (en) |
Cited By (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0947862A2 (en) * | 1998-03-31 | 1999-10-06 | Ntt Advanced Technology Corporation | Method and apparatus for maintaining optical signal having low degree of polarization inspecific state of polyarization |
US20030038948A1 (en) * | 2000-07-07 | 2003-02-27 | Friedrich Prinzhausen | Interferometric, low coherence shape measurement device for a plurality of surfaces (valve seat) via several reference planes |
US6856400B1 (en) | 2000-12-14 | 2005-02-15 | Luna Technologies | Apparatus and method for the complete characterization of optical devices including loss, birefringence and dispersion effects |
US20050140984A1 (en) * | 2003-12-31 | 2005-06-30 | Hitzenberger Christoph K. | Efficient optical coherence tomography (OCT) system and method for rapid imaging in three dimensions |
US20050174578A1 (en) * | 2004-02-10 | 2005-08-11 | Jay Wei | High efficiency low coherence interferometry |
US20050203422A1 (en) * | 2004-02-10 | 2005-09-15 | Jay Wei | Optical apparatus and methods for performing eye examinations |
US20050213103A1 (en) * | 2004-03-29 | 2005-09-29 | Everett Matthew J | Simple high efficiency optical coherence domain reflectometer design |
US20050254061A1 (en) * | 2004-05-14 | 2005-11-17 | Alphonse Gerard A | Low coherence interferometry for detecting and characterizing plaques |
US20050254060A1 (en) * | 2004-05-14 | 2005-11-17 | Alphonse Gerard A | Low coherence interferometry for detecting and characterizing plaques |
US20050254059A1 (en) * | 2004-05-14 | 2005-11-17 | Alphonse Gerard A | Low coherence interferometric system for optical metrology |
US20060072118A1 (en) * | 2004-10-04 | 2006-04-06 | Kabushiki Kaisha Topcon | Optical image measuring apparatus |
US20060171503A1 (en) * | 2005-01-21 | 2006-08-03 | O'hara Keith E | Method to suppress artifacts in frequency-domain optical coherence tomography |
US20060187462A1 (en) * | 2005-01-21 | 2006-08-24 | Vivek Srinivasan | Methods and apparatus for optical coherence tomography scanning |
US7184148B2 (en) | 2004-05-14 | 2007-02-27 | Medeikon Corporation | Low coherence interferometry utilizing phase |
US20070055117A1 (en) * | 2004-05-14 | 2007-03-08 | Alphonse Gerard A | Low coherence interferometry utilizing phase |
US20070064237A1 (en) * | 2003-05-27 | 2007-03-22 | Gelikonov Valentin M | Optical device for studying an object |
US20070278389A1 (en) * | 2006-06-02 | 2007-12-06 | Mahesh Ajgaonkar | Multi-channel low coherence interferometer |
US20070291276A1 (en) * | 2005-02-04 | 2007-12-20 | Carl Zeiss Meditec Ag | Device for Determining the Position of Spaced-Apart Areas in Transparent and/or Diffuse Objects |
US7327463B2 (en) | 2004-05-14 | 2008-02-05 | Medrikon Corporation | Low coherence interferometry utilizing magnitude |
US20090073387A1 (en) * | 2007-09-18 | 2009-03-19 | Meyer Scott A | Rnfl measurement analysis |
US20110292389A1 (en) * | 2009-01-15 | 2011-12-01 | Centre National De La Recherche Scientifique-Cnrs | Device and Method for Determining a Piece of Polarisation Information and Polarimetric Imaging Device |
US20120170046A1 (en) * | 2010-12-30 | 2012-07-05 | Axsun Technologies, Inc. | Integrated Optical Coherence Tomography System |
EP2725966A1 (en) * | 2011-06-28 | 2014-05-07 | Medlumics S.L. | Integrated delay line for optical coherence tomography |
WO2015044232A1 (en) | 2013-09-25 | 2015-04-02 | Carl Zeiss Meditec Ag | Methods and systems for modifying second-order chromatic dispersion in optical coherence tomographic systems |
US9046337B2 (en) | 2010-12-30 | 2015-06-02 | Volcano Corporation | Integrated OCT detector system with transimpedance amplifier |
US20170208297A1 (en) * | 2016-01-20 | 2017-07-20 | Magic Leap, Inc. | Polarizing maintaining optical fiber in virtual/augmented reality system |
US10254536B2 (en) | 2015-07-20 | 2019-04-09 | Magic Leap, Inc. | Collimating fiber scanner design with inward pointing angles in virtual/augmented reality system |
US10317690B2 (en) | 2014-01-31 | 2019-06-11 | Magic Leap, Inc. | Multi-focal display system and method |
US10338391B2 (en) | 2015-10-06 | 2019-07-02 | Magic Leap, Inc. | Virtual/augmented reality system having reverse angle diffraction grating |
US10485422B2 (en) | 2009-02-19 | 2019-11-26 | Manish Dinkarrao Kulkarni | System and method for imaging subsurface of specimen |
US10555669B2 (en) | 2016-11-09 | 2020-02-11 | Amo Wavefront Sciences, Llc | Optical coherence tomography systems and methods with dispersion compensation |
US10705353B1 (en) * | 2018-12-18 | 2020-07-07 | Facebook Technologies, Llc | Waveguide with coherent interference mitigation |
US11016298B2 (en) | 2015-10-05 | 2021-05-25 | Magic Leap, Inc. | Microlens collimator for scanning optical fiber in virtual/augmented reality system |
US11193754B2 (en) | 2018-05-23 | 2021-12-07 | Haag-Streit Ag | OCT system and OCT method |
Families Citing this family (236)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6384915B1 (en) * | 1998-03-30 | 2002-05-07 | The Regents Of The University Of California | Catheter guided by optical coherence domain reflectometry |
DE69938250T2 (en) * | 1998-09-11 | 2009-03-12 | Joseph A. Pepper Pike Izatt | INTERFEROMETERS FOR OPTICAL COHERENCE DOMAIN REFLECTOMETRY AND OPTICAL COHERENCE TOMOGRAPHY USING NON-RECIPROCAL OPTICAL ELEMENTS |
US7778688B2 (en) | 1999-05-18 | 2010-08-17 | MediGuide, Ltd. | System and method for delivering a stent to a selected position within a lumen |
US8442618B2 (en) * | 1999-05-18 | 2013-05-14 | Mediguide Ltd. | Method and system for delivering a medical device to a selected position within a lumen |
US7386339B2 (en) | 1999-05-18 | 2008-06-10 | Mediguide Ltd. | Medical imaging and navigation system |
US9833167B2 (en) * | 1999-05-18 | 2017-12-05 | Mediguide Ltd. | Method and system for superimposing virtual anatomical landmarks on an image |
US9572519B2 (en) | 1999-05-18 | 2017-02-21 | Mediguide Ltd. | Method and apparatus for invasive device tracking using organ timing signal generated from MPS sensors |
US7343195B2 (en) * | 1999-05-18 | 2008-03-11 | Mediguide Ltd. | Method and apparatus for real time quantitative three-dimensional image reconstruction of a moving organ and intra-body navigation |
US7840252B2 (en) | 1999-05-18 | 2010-11-23 | MediGuide, Ltd. | Method and system for determining a three dimensional representation of a tubular organ |
DE60119930T2 (en) * | 2000-07-10 | 2007-01-18 | University Health Network, Toronto | METHOD AND DEVICE FOR HIGHLY RESOLVING COHERENT OPTICAL FIGURE |
US6466713B2 (en) | 2000-08-18 | 2002-10-15 | The Regents Of The University Of California | Optical fiber head for providing lateral viewing |
US6451009B1 (en) * | 2000-09-12 | 2002-09-17 | The Regents Of The University Of California | OCDR guided laser ablation device |
US7231243B2 (en) * | 2000-10-30 | 2007-06-12 | The General Hospital Corporation | Optical methods for tissue analysis |
US9295391B1 (en) | 2000-11-10 | 2016-03-29 | The General Hospital Corporation | Spectrally encoded miniature endoscopic imaging probe |
US8046057B2 (en) * | 2001-04-11 | 2011-10-25 | Clarke Dana S | Tissue structure identification in advance of instrument |
DE10297689B4 (en) | 2001-05-01 | 2007-10-18 | The General Hospital Corp., Boston | Method and device for the determination of atherosclerotic coating by measurement of optical tissue properties |
US6702744B2 (en) * | 2001-06-20 | 2004-03-09 | Advanced Cardiovascular Systems, Inc. | Agents that stimulate therapeutic angiogenesis and techniques and devices that enable their delivery |
US20030045798A1 (en) * | 2001-09-04 | 2003-03-06 | Richard Hular | Multisensor probe for tissue identification |
US6958816B1 (en) | 2001-10-05 | 2005-10-25 | Research Foundation Of The University Of Central Florida | Microrheology methods and systems using low-coherence dynamic light scattering |
US6980299B1 (en) | 2001-10-16 | 2005-12-27 | General Hospital Corporation | Systems and methods for imaging a sample |
US8608661B1 (en) | 2001-11-30 | 2013-12-17 | Advanced Cardiovascular Systems, Inc. | Method for intravascular delivery of a treatment agent beyond a blood vessel wall |
ATE503982T1 (en) * | 2002-01-11 | 2011-04-15 | Gen Hospital Corp | DEVICE FOR OCT IMAGE ACQUISITION WITH AXIAL LINE FOCUS FOR IMPROVED RESOLUTION AND DEPTH OF FIELD |
US7355716B2 (en) * | 2002-01-24 | 2008-04-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
US6852109B2 (en) * | 2002-06-11 | 2005-02-08 | Intraluminal Therapeutics, Inc. | Radio frequency guide wire assembly with optical coherence reflectometry guidance |
US7361368B2 (en) | 2002-06-28 | 2008-04-22 | Advanced Cardiovascular Systems, Inc. | Device and method for combining a treatment agent and a gel |
US7309318B2 (en) * | 2002-09-18 | 2007-12-18 | Boston Scientific Scimed, Inc. | Flexible composite guidewire for intravascular catheter |
DE10255957B4 (en) * | 2002-11-29 | 2010-09-09 | Siemens Ag | Medical examination and / or treatment system |
US7505809B2 (en) * | 2003-01-13 | 2009-03-17 | Mediguide Ltd. | Method and system for registering a first image with a second image relative to the body of a patient |
US8054468B2 (en) | 2003-01-24 | 2011-11-08 | The General Hospital Corporation | Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands |
EP2319404B1 (en) * | 2003-01-24 | 2015-03-11 | The General Hospital Corporation | System and method for identifying tissue low-coherence interferometry |
DE10302785A1 (en) * | 2003-01-24 | 2004-08-19 | Menlo Systems Gmbh | Fiber optic laser resonator for optical coherence tomography has a polarization control unit with which the polarization direction in the resonator can be actively adjusted |
US7474407B2 (en) * | 2003-02-20 | 2009-01-06 | Applied Science Innovations | Optical coherence tomography with 3d coherence scanning |
US20060241342A1 (en) * | 2003-03-13 | 2006-10-26 | Medtronic Transvascular, Inc. | Optically guided penetration catheters and their methods of use |
CN2885311Y (en) | 2006-01-18 | 2007-04-04 | 郑成福 | Via urethra prostate therapeutic equipment using photodynamic therapy |
US7041481B2 (en) | 2003-03-14 | 2006-05-09 | The Regents Of The University Of California | Chemical amplification based on fluid partitioning |
US10376711B2 (en) * | 2003-03-14 | 2019-08-13 | Light Sciences Oncology Inc. | Light generating guide wire for intravascular use |
EP1610865A4 (en) * | 2003-03-14 | 2007-11-28 | Light Sciences Oncology Inc | Light generating device to intravascular use |
US20080269846A1 (en) * | 2003-03-14 | 2008-10-30 | Light Sciences Oncology, Inc. | Device for treatment of blood vessels using light |
US20050131510A1 (en) * | 2003-03-14 | 2005-06-16 | Chen James C. | Device for distal protection and treatment of blood vessels |
EP1611470B1 (en) | 2003-03-31 | 2015-10-14 | The General Hospital Corporation | Speckle reduction in optical coherence tomography by path length encoded angular compounding |
US8821473B2 (en) * | 2003-04-15 | 2014-09-02 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
US7641643B2 (en) | 2003-04-15 | 2010-01-05 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
US8038991B1 (en) | 2003-04-15 | 2011-10-18 | Abbott Cardiovascular Systems Inc. | High-viscosity hyaluronic acid compositions to treat myocardial conditions |
CA2465051C (en) * | 2003-04-23 | 2014-11-18 | John Tulip | Switched photodynamic apparatus |
DE10323217A1 (en) * | 2003-05-22 | 2004-12-16 | Siemens Ag | Optical coherent tomography system of examination of tissues or organs, has position sensor at tip of catheter and reconstructs volume image based on sectional images and associated position data |
AU2004252482B2 (en) | 2003-06-06 | 2011-05-26 | The General Hospital Corporation | Process and apparatus for a wavelength tuning source |
CN103082996A (en) | 2003-10-27 | 2013-05-08 | 通用医疗公司 | Method and apparatus for performing optical imaging by using frequency-domain interferometry |
WO2005054780A1 (en) * | 2003-11-28 | 2005-06-16 | The General Hospital Corporation | Method and apparatus for three-dimensional spectrally encoded imaging |
US20050171437A1 (en) * | 2004-01-14 | 2005-08-04 | Neptec Optical Solutions, Inc. | Optical switching system for catheter-based analysis and treatment |
EP1722669A4 (en) * | 2004-02-27 | 2009-05-27 | Optiscan Pty Ltd | Optical element |
JP4750786B2 (en) | 2004-05-29 | 2011-08-17 | ザ ジェネラル ホスピタル コーポレイション | Chromatic dispersion compensation process, system and software configuration using refractive layer in optical coherence tomography (OCT) imaging |
AU2005270037B2 (en) | 2004-07-02 | 2012-02-09 | The General Hospital Corporation | Endoscopic imaging probe comprising dual clad fibre |
WO2006014688A2 (en) * | 2004-07-20 | 2006-02-09 | Neptec Optical Solutions. Inc. | Optical monitoring system with molecular filters |
WO2006020292A2 (en) * | 2004-07-20 | 2006-02-23 | Prescient Medical, Inc. | Systems and methods for medical interventional optical monitoring with molecular filters |
US7242832B2 (en) * | 2004-07-27 | 2007-07-10 | Medeikon Corporation | Device for tissue characterization |
EP1782020B1 (en) | 2004-08-06 | 2012-10-03 | The General Hospital Corporation | Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography |
EP1793731B1 (en) | 2004-08-24 | 2013-12-25 | The General Hospital Corporation | Imaging apparatus comprising a fluid delivery arrangement and a pull-back arrangement |
JP5334415B2 (en) * | 2004-08-24 | 2013-11-06 | ザ ジェネラル ホスピタル コーポレイション | Process, system and software for measuring mechanical strain and elastic properties of samples |
JP5215664B2 (en) * | 2004-09-10 | 2013-06-19 | ザ ジェネラル ホスピタル コーポレイション | System and method for optical coherence imaging |
WO2006037132A1 (en) | 2004-09-29 | 2006-04-06 | The General Hospital Corporation | System and method for optical coherence imaging |
EP1819270B1 (en) * | 2004-10-29 | 2012-12-19 | The General Hospital Corporation | Polarization-sensitive optical coherence tomography |
WO2006050453A1 (en) * | 2004-11-02 | 2006-05-11 | The General Hospital Corporation | Fiber-optic rotational device, optical system and method for imaging a sample |
WO2006054975A1 (en) * | 2004-11-12 | 2006-05-26 | Medeikon Corporation | Single trace multi-channel low coherence interferometric sensor |
US7417740B2 (en) * | 2004-11-12 | 2008-08-26 | Medeikon Corporation | Single trace multi-channel low coherence interferometric sensor |
US7388672B2 (en) * | 2004-11-19 | 2008-06-17 | Carl Ziess Meditec, Inc. | High efficiency balanced detection interferometer |
EP1825214A1 (en) * | 2004-11-24 | 2007-08-29 | The General Hospital Corporation | Common-path interferometer for endoscopic oct |
EP1816949A1 (en) * | 2004-11-29 | 2007-08-15 | The General Hospital Corporation | Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample |
US7854944B2 (en) | 2004-12-17 | 2010-12-21 | Advanced Cardiovascular Systems, Inc. | Tissue regeneration |
US8075498B2 (en) | 2005-03-04 | 2011-12-13 | Endosense Sa | Medical apparatus system having optical fiber load sensing capability |
US8182433B2 (en) * | 2005-03-04 | 2012-05-22 | Endosense Sa | Medical apparatus system having optical fiber load sensing capability |
US8828433B2 (en) | 2005-04-19 | 2014-09-09 | Advanced Cardiovascular Systems, Inc. | Hydrogel bioscaffoldings and biomedical device coatings |
US20080125745A1 (en) | 2005-04-19 | 2008-05-29 | Shubhayu Basu | Methods and compositions for treating post-cardial infarction damage |
US9539410B2 (en) | 2005-04-19 | 2017-01-10 | Abbott Cardiovascular Systems Inc. | Methods and compositions for treating post-cardial infarction damage |
US8187621B2 (en) | 2005-04-19 | 2012-05-29 | Advanced Cardiovascular Systems, Inc. | Methods and compositions for treating post-myocardial infarction damage |
US8303972B2 (en) * | 2005-04-19 | 2012-11-06 | Advanced Cardiovascular Systems, Inc. | Hydrogel bioscaffoldings and biomedical device coatings |
JP2008538612A (en) * | 2005-04-22 | 2008-10-30 | ザ ジェネラル ホスピタル コーポレイション | Configuration, system, and method capable of providing spectral domain polarization sensitive optical coherence tomography |
EP2085929A1 (en) * | 2005-04-28 | 2009-08-05 | The General Hospital Corporation | Evaluating optical coherence tomography information for an anatomical structure |
WO2006124860A1 (en) * | 2005-05-13 | 2006-11-23 | The General Hospital Corporation | Arrangements, systems and methods capable of providing spectral-domain optical coherence reflectometry for a sensitive detection of chemical and biological sample |
EP1887926B1 (en) * | 2005-05-31 | 2014-07-30 | The General Hospital Corporation | System and method which use spectral encoding heterodyne interferometry techniques for imaging |
WO2006130802A2 (en) | 2005-06-01 | 2006-12-07 | The General Hospital Corporation | Apparatus, method and system for performing phase-resolved optical frequency domain imaging |
EP3028645B1 (en) * | 2005-08-01 | 2019-09-18 | St. Jude Medical International Holding S.à r.l. | Medical apparatus system having optical fiber load sensing capability |
EP1913332B1 (en) * | 2005-08-09 | 2010-10-13 | The General Hospital Corporation | Apparatus and method for performing polarization-based quadrature demodulation in optical coherence tomography |
US20070049833A1 (en) * | 2005-08-16 | 2007-03-01 | The General Hospital Corporation | Arrangements and methods for imaging in vessels |
US7843572B2 (en) * | 2005-09-29 | 2010-11-30 | The General Hospital Corporation | Method and apparatus for optical imaging via spectral encoding |
US7889348B2 (en) * | 2005-10-14 | 2011-02-15 | The General Hospital Corporation | Arrangements and methods for facilitating photoluminescence imaging |
WO2007082228A1 (en) | 2006-01-10 | 2007-07-19 | The General Hospital Corporation | Systems and methods for generating data based on one or more spectrally-encoded endoscopy techniques |
EP2289399A3 (en) | 2006-01-19 | 2011-04-06 | The General Hospital Corporation | Methods and systems for optical imaging of epithelial luminal organs by beam scanning thereof |
US20070223006A1 (en) * | 2006-01-19 | 2007-09-27 | The General Hospital Corporation | Systems and methods for performing rapid fluorescence lifetime, excitation and emission spectral measurements |
WO2007084903A2 (en) | 2006-01-19 | 2007-07-26 | The General Hospital Corporation | Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and method for producing one or more optical arrangements |
US20070171430A1 (en) * | 2006-01-20 | 2007-07-26 | The General Hospital Corporation | Systems and methods for providing mirror tunnel micropscopy |
CN101370426A (en) * | 2006-01-20 | 2009-02-18 | 通用医疗公司 | Systems, arrangement and process for providing speckle reductions using a wave front modulation for optical coherence tomography |
WO2007084933A2 (en) * | 2006-01-20 | 2007-07-26 | The General Hospital Corporation | Systems and processes for providing endogenous molecular imaging with mid-infared light |
US7636166B2 (en) * | 2006-01-23 | 2009-12-22 | Zygo Corporation | Interferometer system for monitoring an object |
JP2009537024A (en) * | 2006-02-01 | 2009-10-22 | ザ ジェネラル ホスピタル コーポレイション | Apparatus for controlling at least one of at least two sites of at least one fiber |
JP5680829B2 (en) * | 2006-02-01 | 2015-03-04 | ザ ジェネラル ホスピタル コーポレイション | A device that irradiates a sample with multiple electromagnetic radiations |
WO2007149602A2 (en) * | 2006-02-01 | 2007-12-27 | The General Hospital Corporation | Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures |
EP3143926B1 (en) | 2006-02-08 | 2020-07-01 | The General Hospital Corporation | Methods, arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy |
WO2007101026A2 (en) * | 2006-02-24 | 2007-09-07 | The General Hospital Corporation | Methods and systems for performing angle-resolved fourier-domain optical coherence tomography |
WO2007103721A2 (en) * | 2006-03-01 | 2007-09-13 | The General Hospital Corporation | System and method for providing cell specific laser therapy of atherosclerotic plaques by targeting light absorbers in macrophages |
WO2007109540A2 (en) * | 2006-03-17 | 2007-09-27 | The General Hospital Corporation | Arrangement, method and computer-accessible medium for identifying characteristics of at least a portion of a blood vessel contained within a tissue using spectral domain low coherence interferometry |
CN101466298B (en) * | 2006-04-05 | 2011-08-31 | 通用医疗公司 | Methods arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample |
WO2007133961A2 (en) * | 2006-05-10 | 2007-11-22 | The General Hospital Corporation | Processes, arrangements and systems for providing frequency domain imaging of a sample |
US7782464B2 (en) * | 2006-05-12 | 2010-08-24 | The General Hospital Corporation | Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images |
US8048063B2 (en) * | 2006-06-09 | 2011-11-01 | Endosense Sa | Catheter having tri-axial force sensor |
US8567265B2 (en) | 2006-06-09 | 2013-10-29 | Endosense, SA | Triaxial fiber optic force sensing catheter |
US7732190B2 (en) * | 2006-07-31 | 2010-06-08 | Advanced Cardiovascular Systems, Inc. | Modified two-component gelation systems, methods of use and methods of manufacture |
US20100165335A1 (en) * | 2006-08-01 | 2010-07-01 | The General Hospital Corporation | Systems and methods for receiving and/or analyzing information associated with electro-magnetic radiation |
JP2008070349A (en) * | 2006-08-15 | 2008-03-27 | Fujifilm Corp | Optical tomographic imaging apparatus |
US9242005B1 (en) | 2006-08-21 | 2016-01-26 | Abbott Cardiovascular Systems Inc. | Pro-healing agent formulation compositions, methods and treatments |
EP3006920A3 (en) * | 2006-08-25 | 2016-08-03 | The General Hospital Corporation | Apparatus and methods for enhancing optical coherence tomography imaging using volumetric filtering techniques |
WO2008030886A1 (en) * | 2006-09-06 | 2008-03-13 | Cardiofirst | Guidance system used in treating chronic occlusion |
EP2077753B1 (en) * | 2006-09-12 | 2012-12-19 | The General Hospital Corporation | Apparatus, probe and method for providing depth assessment in an anatomical structure |
WO2008049118A2 (en) | 2006-10-19 | 2008-04-24 | The General Hospital Corporation | Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s) |
US9005672B2 (en) * | 2006-11-17 | 2015-04-14 | Abbott Cardiovascular Systems Inc. | Methods of modifying myocardial infarction expansion |
US8741326B2 (en) * | 2006-11-17 | 2014-06-03 | Abbott Cardiovascular Systems Inc. | Modified two-component gelation systems, methods of use and methods of manufacture |
US8192760B2 (en) | 2006-12-04 | 2012-06-05 | Abbott Cardiovascular Systems Inc. | Methods and compositions for treating tissue using silk proteins |
US7949019B2 (en) * | 2007-01-19 | 2011-05-24 | The General Hospital | Wavelength tuning source based on a rotatable reflector |
US20080206804A1 (en) * | 2007-01-19 | 2008-08-28 | The General Hospital Corporation | Arrangements and methods for multidimensional multiplexed luminescence imaging and diagnosis |
EP2102583A2 (en) | 2007-01-19 | 2009-09-23 | The General Hospital Corporation | Apparatus and method for controlling ranging depth in optical frequency domain imaging |
WO2008116010A1 (en) * | 2007-03-19 | 2008-09-25 | The General Hospital Corporation | System and method for providing noninvasive diagnosis of compartment syndrome exemplary laser speckle imaging procedure |
WO2008115965A1 (en) * | 2007-03-19 | 2008-09-25 | The General Hospital Corporation | Apparatus and method for providing a noninvasive diagnosis of internal bleeding |
US9176319B2 (en) * | 2007-03-23 | 2015-11-03 | The General Hospital Corporation | Methods, arrangements and apparatus for utilizing a wavelength-swept laser using angular scanning and dispersion procedures |
WO2008121844A1 (en) * | 2007-03-30 | 2008-10-09 | The General Hospital Corporation | System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque |
WO2008131082A1 (en) | 2007-04-17 | 2008-10-30 | The General Hospital Corporation | Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy techniques |
US8115919B2 (en) * | 2007-05-04 | 2012-02-14 | The General Hospital Corporation | Methods, arrangements and systems for obtaining information associated with a sample using optical microscopy |
US8157789B2 (en) * | 2007-05-24 | 2012-04-17 | Endosense Sa | Touch sensing catheter |
US8622935B1 (en) | 2007-05-25 | 2014-01-07 | Endosense Sa | Elongated surgical manipulator with body position and distal force sensing |
US9375158B2 (en) * | 2007-07-31 | 2016-06-28 | The General Hospital Corporation | Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging |
US8040608B2 (en) * | 2007-08-31 | 2011-10-18 | The General Hospital Corporation | System and method for self-interference fluorescence microscopy, and computer-accessible medium associated therewith |
US20090073439A1 (en) * | 2007-09-15 | 2009-03-19 | The General Hospital Corporation | Apparatus, computer-accessible medium and method for measuring chemical and/or molecular compositions of coronary atherosclerotic plaques in anatomical structures |
WO2009049296A2 (en) * | 2007-10-12 | 2009-04-16 | The General Hospital Corporation | Systems and processes for optical imaging of luminal anatomic structures |
WO2009059034A1 (en) * | 2007-10-30 | 2009-05-07 | The General Hospital Corporation | System and method for cladding mode detection |
US7573020B1 (en) * | 2008-01-17 | 2009-08-11 | Imalux Corporation | Optoelectronic probe system with all-optical coupling |
US20090225324A1 (en) * | 2008-01-17 | 2009-09-10 | The General Hospital Corporation | Apparatus for providing endoscopic high-speed optical coherence tomography |
US11123047B2 (en) | 2008-01-28 | 2021-09-21 | The General Hospital Corporation | Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood |
US9332942B2 (en) * | 2008-01-28 | 2016-05-10 | The General Hospital Corporation | Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging |
US8062316B2 (en) | 2008-04-23 | 2011-11-22 | Avinger, Inc. | Catheter system and method for boring through blocked vascular passages |
US8696695B2 (en) * | 2009-04-28 | 2014-04-15 | Avinger, Inc. | Guidewire positioning catheter |
US9125562B2 (en) | 2009-07-01 | 2015-09-08 | Avinger, Inc. | Catheter-based off-axis optical coherence tomography imaging system |
EP2274572A4 (en) | 2008-05-07 | 2013-08-28 | Gen Hospital Corp | System, method and computer-accessible medium for tracking vessel motion during three-dimensional coronary artery microscopy |
US8298227B2 (en) * | 2008-05-14 | 2012-10-30 | Endosense Sa | Temperature compensated strain sensing catheter |
JP5795531B2 (en) * | 2008-06-20 | 2015-10-14 | ザ ジェネラル ホスピタル コーポレイション | Fused fiber optic coupler structure and method of using the same |
EP2309923B1 (en) * | 2008-07-14 | 2020-11-25 | The General Hospital Corporation | Apparatus and methods for color endoscopy |
US9492797B2 (en) | 2008-09-23 | 2016-11-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
US9222128B2 (en) | 2011-03-18 | 2015-12-29 | Bio-Rad Laboratories, Inc. | Multiplexed digital assays with combinatorial use of signals |
US8709762B2 (en) | 2010-03-02 | 2014-04-29 | Bio-Rad Laboratories, Inc. | System for hot-start amplification via a multiple emulsion |
US9132394B2 (en) | 2008-09-23 | 2015-09-15 | Bio-Rad Laboratories, Inc. | System for detection of spaced droplets |
US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
US9764322B2 (en) | 2008-09-23 | 2017-09-19 | Bio-Rad Laboratories, Inc. | System for generating droplets with pressure monitoring |
US9194861B2 (en) * | 2009-09-02 | 2015-11-24 | Bio-Rad Laboratories, Inc. | Method of mixing fluids by coalescence of multiple emulsions |
US8633015B2 (en) * | 2008-09-23 | 2014-01-21 | Bio-Rad Laboratories, Inc. | Flow-based thermocycling system with thermoelectric cooler |
US12090480B2 (en) | 2008-09-23 | 2024-09-17 | Bio-Rad Laboratories, Inc. | Partition-based method of analysis |
US9417190B2 (en) | 2008-09-23 | 2016-08-16 | Bio-Rad Laboratories, Inc. | Calibrations and controls for droplet-based assays |
US8951939B2 (en) | 2011-07-12 | 2015-02-10 | Bio-Rad Laboratories, Inc. | Digital assays with multiplexed detection of two or more targets in the same optical channel |
US11130128B2 (en) | 2008-09-23 | 2021-09-28 | Bio-Rad Laboratories, Inc. | Detection method for a target nucleic acid |
US10512910B2 (en) | 2008-09-23 | 2019-12-24 | Bio-Rad Laboratories, Inc. | Droplet-based analysis method |
US9399215B2 (en) | 2012-04-13 | 2016-07-26 | Bio-Rad Laboratories, Inc. | Sample holder with a well having a wicking promoter |
US8120781B2 (en) * | 2008-11-26 | 2012-02-21 | Zygo Corporation | Interferometric systems and methods featuring spectral analysis of unevenly sampled data |
ES2957932T3 (en) | 2008-12-10 | 2024-01-30 | Massachusetts Gen Hospital | Systems, apparatus and procedures for extending the image depth range of optical coherence tomography using optical subsampling |
US8097864B2 (en) * | 2009-01-26 | 2012-01-17 | The General Hospital Corporation | System, method and computer-accessible medium for providing wide-field superresolution microscopy |
CN104134928A (en) | 2009-02-04 | 2014-11-05 | 通用医疗公司 | Apparatus and method for utilization of a high-speed optical wavelength tuning source |
US20100228132A1 (en) | 2009-03-08 | 2010-09-09 | Jeffrey Brennan | Systems for controlling optical probe functions during medical and veterinary procedures |
WO2010105197A2 (en) | 2009-03-12 | 2010-09-16 | The General Hospital Corporation | Non-contact optical system, computer-accessible medium and method for measuring at least one mechanical property of tissue using coherent speckle techniques(s) |
CA2763324C (en) | 2009-05-28 | 2018-10-23 | Avinger, Inc. | Optical coherence tomography for biological imaging |
WO2011003006A2 (en) | 2009-07-01 | 2011-01-06 | Avinger, Inc. | Atherectomy catheter with laterally-displaceable tip |
WO2011008822A2 (en) | 2009-07-14 | 2011-01-20 | The General Hospital Corporation | Apparatus, systems and methods for measuring flow and pressure within a vessel |
EP2485641A4 (en) * | 2009-10-06 | 2015-10-14 | Gen Hospital Corp | Apparatus and methods for imaging particular cells including eosinophils |
WO2011072068A2 (en) | 2009-12-08 | 2011-06-16 | Avinger, Inc. | Devices and methods for predicting and preventing restenosis |
EP2509488A4 (en) * | 2009-12-08 | 2014-04-09 | Gen Hospital Corp | Methods and arrangements for analysis, diagnosis, and treatment monitoring of vocal folds by optical coherence tomography |
US8399198B2 (en) | 2010-03-02 | 2013-03-19 | Bio-Rad Laboratories, Inc. | Assays with droplets transformed into capsules |
EP2542145B1 (en) * | 2010-03-05 | 2020-08-12 | The General Hospital Corporation | Systems which provide microscopic images of at least one anatomical structure at a particular resolution |
CA2767114A1 (en) | 2010-03-25 | 2011-09-29 | Bio-Rad Laboratories, Inc. | Droplet transport system for detection |
EP2550351A4 (en) | 2010-03-25 | 2014-07-09 | Quantalife Inc | Detection system for droplet-based assays |
CA2767182C (en) | 2010-03-25 | 2020-03-24 | Bio-Rad Laboratories, Inc. | Droplet generation for droplet-based assays |
US9069130B2 (en) | 2010-05-03 | 2015-06-30 | The General Hospital Corporation | Apparatus, method and system for generating optical radiation from biological gain media |
US8711364B2 (en) | 2010-05-13 | 2014-04-29 | Oprobe, Llc | Optical coherence tomography with multiple sample arms |
WO2011149972A2 (en) | 2010-05-25 | 2011-12-01 | The General Hospital Corporation | Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions |
EP2575598A2 (en) | 2010-05-25 | 2013-04-10 | The General Hospital Corporation | Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images |
US10285568B2 (en) | 2010-06-03 | 2019-05-14 | The General Hospital Corporation | Apparatus and method for devices for imaging structures in or at one or more luminal organs |
US11382653B2 (en) | 2010-07-01 | 2022-07-12 | Avinger, Inc. | Atherectomy catheter |
JP2013531542A (en) | 2010-07-01 | 2013-08-08 | アビンガー・インコーポレイテッド | An atherectomy catheter having a longitudinally movable drive shaft |
US9510758B2 (en) | 2010-10-27 | 2016-12-06 | The General Hospital Corporation | Apparatus, systems and methods for measuring blood pressure within at least one vessel |
DE202011110979U1 (en) | 2010-11-01 | 2017-12-04 | Bio-Rad Laboratories, Inc. | System for forming emulsions |
US12097495B2 (en) | 2011-02-18 | 2024-09-24 | Bio-Rad Laboratories, Inc. | Methods and compositions for detecting genetic material |
WO2012145133A2 (en) | 2011-03-28 | 2012-10-26 | Avinger, Inc. | Occlusion-crossing devices, imaging, and atherectomy devices |
US9949754B2 (en) | 2011-03-28 | 2018-04-24 | Avinger, Inc. | Occlusion-crossing devices |
WO2012142588A1 (en) | 2011-04-14 | 2012-10-18 | Endosense S.A. | Compact force sensor for catheters |
JP2014512826A (en) | 2011-04-25 | 2014-05-29 | バイオ−ラド ラボラトリーズ インコーポレイテッド | Methods and compositions for nucleic acid analysis |
JP6240064B2 (en) | 2011-04-29 | 2017-11-29 | ザ ジェネラル ホスピタル コーポレイション | Method for determining depth-resolved physical and / or optical properties of a scattering medium |
US9330092B2 (en) | 2011-07-19 | 2016-05-03 | The General Hospital Corporation | Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography |
WO2013019751A1 (en) | 2011-07-29 | 2013-02-07 | Bio-Rad Laboratories, Inc., | Library characterization by digital assay |
EP2748587B1 (en) | 2011-08-25 | 2021-01-13 | The General Hospital Corporation | Methods and arrangements for providing micro-optical coherence tomography procedures |
AT511935B1 (en) * | 2011-09-12 | 2015-09-15 | Ima Integrated Microsystems Austria Gmbh | METHOD AND DEVICE FOR SPATIAL MEASUREMENT OF TISSUE STRUCTURES |
JP6356604B2 (en) | 2011-10-17 | 2018-07-11 | アビンガー・インコーポレイテッドAvinger, Inc. | Atherotomy catheters and non-contact actuation mechanisms for catheters |
EP2769491A4 (en) | 2011-10-18 | 2015-07-22 | Gen Hospital Corp | Apparatus and methods for producing and/or providing recirculating optical delay(s) |
US9345406B2 (en) | 2011-11-11 | 2016-05-24 | Avinger, Inc. | Occlusion-crossing devices, atherectomy devices, and imaging |
US9629528B2 (en) | 2012-03-30 | 2017-04-25 | The General Hospital Corporation | Imaging system, method and distal attachment for multidirectional field of view endoscopy |
WO2013172970A1 (en) | 2012-05-14 | 2013-11-21 | Avinger, Inc. | Atherectomy catheters with imaging |
WO2013172972A1 (en) | 2012-05-14 | 2013-11-21 | Avinger, Inc. | Optical coherence tomography with graded index fiber for biological imaging |
EP2849660B1 (en) | 2012-05-14 | 2021-08-25 | Avinger, Inc. | Atherectomy catheter drive assemblies |
EP2852315A4 (en) | 2012-05-21 | 2016-06-08 | Gen Hospital Corp | Apparatus, device and method for capsule microscopy |
US10506934B2 (en) | 2012-05-25 | 2019-12-17 | Phyzhon Health Inc. | Optical fiber pressure sensor |
EP2888616A4 (en) | 2012-08-22 | 2016-04-27 | Gen Hospital Corp | System, method, and computer-accessible medium for fabrication minature endoscope using soft lithography |
US11284916B2 (en) | 2012-09-06 | 2022-03-29 | Avinger, Inc. | Atherectomy catheters and occlusion crossing devices |
JP6523170B2 (en) | 2012-09-06 | 2019-05-29 | アビンガー・インコーポレイテッドAvinger, Inc. | Atheroma catheter and atheroma assembly |
WO2015120146A1 (en) | 2014-02-06 | 2015-08-13 | Avinger, Inc. | Atherectomy catheters and occlusion crossing devices |
US10335173B2 (en) | 2012-09-06 | 2019-07-02 | Avinger, Inc. | Re-entry stylet for catheter |
US9498247B2 (en) | 2014-02-06 | 2016-11-22 | Avinger, Inc. | Atherectomy catheters and occlusion crossing devices |
US10893806B2 (en) | 2013-01-29 | 2021-01-19 | The General Hospital Corporation | Apparatus, systems and methods for providing information regarding the aortic valve |
WO2014121082A1 (en) | 2013-02-01 | 2014-08-07 | The General Hospital Corporation | Objective lens arrangement for confocal endomicroscopy |
WO2014144709A2 (en) | 2013-03-15 | 2014-09-18 | The General Hospital Corporation | Methods and systems for characterizing an object |
JP6291025B2 (en) | 2013-03-15 | 2018-03-14 | アビンガー・インコーポレイテッドAvinger, Inc. | Optical pressure sensor assembly |
US9854979B2 (en) | 2013-03-15 | 2018-01-02 | Avinger, Inc. | Chronic total occlusion crossing devices with imaging |
US11096717B2 (en) | 2013-03-15 | 2021-08-24 | Avinger, Inc. | Tissue collection device for catheter |
US9784681B2 (en) | 2013-05-13 | 2017-10-10 | The General Hospital Corporation | System and method for efficient detection of the phase and amplitude of a periodic modulation associated with self-interfering fluorescence |
WO2015006353A1 (en) | 2013-07-08 | 2015-01-15 | Avinger, Inc. | Identification of elastic lamina to guide interventional therapy |
WO2015009932A1 (en) | 2013-07-19 | 2015-01-22 | The General Hospital Corporation | Imaging apparatus and method which utilizes multidirectional field of view endoscopy |
EP3021735A4 (en) | 2013-07-19 | 2017-04-19 | The General Hospital Corporation | Determining eye motion by imaging retina. with feedback |
EP3910282B1 (en) | 2013-07-26 | 2024-01-17 | The General Hospital Corporation | Method of providing a laser radiation with a laser arrangement utilizing optical dispersion for applications in fourier-domain optical coherence tomography |
US10327645B2 (en) | 2013-10-04 | 2019-06-25 | Vascular Imaging Corporation | Imaging techniques using an imaging guidewire |
US10537255B2 (en) | 2013-11-21 | 2020-01-21 | Phyzhon Health Inc. | Optical fiber pressure sensor |
WO2015105870A1 (en) | 2014-01-08 | 2015-07-16 | The General Hospital Corporation | Method and apparatus for microscopic imaging |
US10736494B2 (en) | 2014-01-31 | 2020-08-11 | The General Hospital Corporation | System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device |
WO2015153982A1 (en) | 2014-04-04 | 2015-10-08 | The General Hospital Corporation | Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s) |
WO2016007652A1 (en) | 2014-07-08 | 2016-01-14 | Avinger, Inc. | High speed chronic total occlusion crossing devices |
EP3171766B1 (en) | 2014-07-25 | 2021-12-29 | The General Hospital Corporation | Apparatus for in vivo imaging and diagnosis |
US10206584B2 (en) * | 2014-08-08 | 2019-02-19 | Medlumics S.L. | Optical coherence tomography probe for crossing coronary occlusions |
US10258240B1 (en) | 2014-11-24 | 2019-04-16 | Vascular Imaging Corporation | Optical fiber pressure sensor |
CN107920780B (en) | 2015-07-13 | 2022-01-11 | 阿维格公司 | Micro-molded anamorphic reflective lens for image guided therapy/diagnostic catheter |
US10194981B2 (en) * | 2015-07-29 | 2019-02-05 | Medlumics S.L. | Radiofrequency ablation catheter with optical tissue evaluation |
CN108430368B (en) | 2016-01-07 | 2022-05-31 | 圣犹达医疗用品国际控股有限公司 | Medical device with multi-core optical fiber for optical sensing |
AU2017212407A1 (en) | 2016-01-25 | 2018-08-02 | Avinger, Inc. | OCT imaging catheter with lag correction |
JP6959255B2 (en) | 2016-04-01 | 2021-11-02 | アビンガー・インコーポレイテッドAvinger, Inc. | Catheter device for porridge resection |
US11344327B2 (en) | 2016-06-03 | 2022-05-31 | Avinger, Inc. | Catheter device with detachable distal end |
US11224459B2 (en) | 2016-06-30 | 2022-01-18 | Avinger, Inc. | Atherectomy catheter with shapeable distal tip |
EP4044942A4 (en) | 2019-10-18 | 2023-11-15 | Avinger, Inc. | Occlusion-crossing devices |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5139494A (en) | 1988-11-10 | 1992-08-18 | Premier Laser Systems, Inc. | Multiwavelength medical laser method |
US5202745A (en) * | 1990-11-07 | 1993-04-13 | Hewlett-Packard Company | Polarization independent optical coherence-domain reflectometry |
US5268741A (en) | 1992-01-31 | 1993-12-07 | Hewlett-Packard Company | Method and apparatus for calibrating a polarization independent optical coherence domain reflectometer |
US5321501A (en) * | 1991-04-29 | 1994-06-14 | Massachusetts Institute Of Technology | Method and apparatus for optical imaging with means for controlling the longitudinal range of the sample |
US5441053A (en) | 1991-05-03 | 1995-08-15 | University Of Kentucky Research Foundation | Apparatus and method for multiple wavelength of tissue |
US5465147A (en) | 1991-04-29 | 1995-11-07 | Massachusetts Institute Of Technology | Method and apparatus for acquiring images using a ccd detector array and no transverse scanner |
US5573531A (en) | 1994-06-20 | 1996-11-12 | Gregory; Kenton W. | Fluid core laser angioscope |
WO1999002095A1 (en) | 1997-07-09 | 1999-01-21 | Intraluminal Therapeutics, Inc. | Systems and methods for steering a catheter through body tissue |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2048278C (en) | 1990-11-07 | 2002-07-23 | Wayne V. Sorin | Polarization independent optical coherence-domain reflectometry |
US6134003A (en) | 1991-04-29 | 2000-10-17 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope |
US5212586A (en) * | 1991-11-26 | 1993-05-18 | Optics For Research | Optical circulator having a simplified construction |
US5453827A (en) * | 1993-02-24 | 1995-09-26 | Dicon Fiberoptics | Fiberoptic in-line filter and technique for measuring the transmission quality of an optical fiber through the use of a fiberoptic in-line filter |
US5570182A (en) | 1994-05-27 | 1996-10-29 | Regents Of The University Of California | Method for detection of dental caries and periodontal disease using optical imaging |
US5491524A (en) * | 1994-10-05 | 1996-02-13 | Carl Zeiss, Inc. | Optical coherence tomography corneal mapping apparatus |
RU2100787C1 (en) * | 1995-03-01 | 1997-12-27 | Геликонов Валентин Михайлович | Fibre-optical interferometer and fiber-optical piezoelectric transducer |
US5879306A (en) * | 1996-06-13 | 1999-03-09 | Stryker Corporation | Infrared system for visualizing body members |
US5911017A (en) * | 1996-07-31 | 1999-06-08 | Visionex, Inc. | Fiber optic interface for laser spectroscopic Raman probes |
US5901261A (en) * | 1997-06-19 | 1999-05-04 | Visionex, Inc. | Fiber optic interface for optical probes with enhanced photonic efficiency, light manipulation, and stray light rejection |
-
1998
- 1998-03-30 US US09/050,571 patent/US6175669B1/en not_active Expired - Fee Related
-
1999
- 1999-03-30 AU AU31200/99A patent/AU3120099A/en not_active Abandoned
- 1999-03-30 WO PCT/US1999/006926 patent/WO1999049780A1/en active Application Filing
-
2000
- 2000-01-07 US US09/479,674 patent/US6385358B1/en not_active Expired - Lifetime
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5139494A (en) | 1988-11-10 | 1992-08-18 | Premier Laser Systems, Inc. | Multiwavelength medical laser method |
US5540676A (en) | 1988-11-10 | 1996-07-30 | Premier Laser Systems, Inc. | Method of laser surgery using multiple wavelengths |
US5202745A (en) * | 1990-11-07 | 1993-04-13 | Hewlett-Packard Company | Polarization independent optical coherence-domain reflectometry |
US5321501A (en) * | 1991-04-29 | 1994-06-14 | Massachusetts Institute Of Technology | Method and apparatus for optical imaging with means for controlling the longitudinal range of the sample |
US5459570A (en) * | 1991-04-29 | 1995-10-17 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements |
US5465147A (en) | 1991-04-29 | 1995-11-07 | Massachusetts Institute Of Technology | Method and apparatus for acquiring images using a ccd detector array and no transverse scanner |
US5441053A (en) | 1991-05-03 | 1995-08-15 | University Of Kentucky Research Foundation | Apparatus and method for multiple wavelength of tissue |
US5268741A (en) | 1992-01-31 | 1993-12-07 | Hewlett-Packard Company | Method and apparatus for calibrating a polarization independent optical coherence domain reflectometer |
US5573531A (en) | 1994-06-20 | 1996-11-12 | Gregory; Kenton W. | Fluid core laser angioscope |
WO1999002095A1 (en) | 1997-07-09 | 1999-01-21 | Intraluminal Therapeutics, Inc. | Systems and methods for steering a catheter through body tissue |
Cited By (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0947862A3 (en) * | 1998-03-31 | 2004-03-17 | Ntt Advanced Technology Corporation | Method and apparatus for maintaining optical signal having low degree of polarization in specific state of polarization |
EP0947862A2 (en) * | 1998-03-31 | 1999-10-06 | Ntt Advanced Technology Corporation | Method and apparatus for maintaining optical signal having low degree of polarization inspecific state of polyarization |
US6822746B2 (en) * | 2000-07-07 | 2004-11-23 | Robert Bosch Gmbh | Interferometric, low coherence shape measurement device for a plurality of surfaces (valve seat) via several reference planes |
US20030038948A1 (en) * | 2000-07-07 | 2003-02-27 | Friedrich Prinzhausen | Interferometric, low coherence shape measurement device for a plurality of surfaces (valve seat) via several reference planes |
US7042573B2 (en) | 2000-12-14 | 2006-05-09 | Luna Innovations Incorporated | Apparatus and method for the complete characterization of optical devices including loss, birefringence and dispersion effects |
US6856400B1 (en) | 2000-12-14 | 2005-02-15 | Luna Technologies | Apparatus and method for the complete characterization of optical devices including loss, birefringence and dispersion effects |
US20050088661A1 (en) * | 2000-12-14 | 2005-04-28 | Luna Technologies | Apparatus and method for the complete characterization of optical devices including loss, birefringence and dispersion effects |
US20070064237A1 (en) * | 2003-05-27 | 2007-03-22 | Gelikonov Valentin M | Optical device for studying an object |
US20050140984A1 (en) * | 2003-12-31 | 2005-06-30 | Hitzenberger Christoph K. | Efficient optical coherence tomography (OCT) system and method for rapid imaging in three dimensions |
US7145661B2 (en) | 2003-12-31 | 2006-12-05 | Carl Zeiss Meditec, Inc. | Efficient optical coherence tomography (OCT) system and method for rapid imaging in three dimensions |
US20050174578A1 (en) * | 2004-02-10 | 2005-08-11 | Jay Wei | High efficiency low coherence interferometry |
US20050203422A1 (en) * | 2004-02-10 | 2005-09-15 | Jay Wei | Optical apparatus and methods for performing eye examinations |
US7631970B2 (en) | 2004-02-10 | 2009-12-15 | Carl Zeiss Meditec, Inc. | Optical apparatus and methods for performing eye examinations |
US7280221B2 (en) * | 2004-02-10 | 2007-10-09 | Optovue, Inc. | High efficiency low coherence interferometry |
US20050213103A1 (en) * | 2004-03-29 | 2005-09-29 | Everett Matthew J | Simple high efficiency optical coherence domain reflectometer design |
US7126693B2 (en) | 2004-03-29 | 2006-10-24 | Carl Zeiss Meditec, Inc. | Simple high efficiency optical coherence domain reflectometer design |
US7327463B2 (en) | 2004-05-14 | 2008-02-05 | Medrikon Corporation | Low coherence interferometry utilizing magnitude |
US20050254061A1 (en) * | 2004-05-14 | 2005-11-17 | Alphonse Gerard A | Low coherence interferometry for detecting and characterizing plaques |
US7474408B2 (en) | 2004-05-14 | 2009-01-06 | Medeikon Corporation | Low coherence interferometry utilizing phase |
US7184148B2 (en) | 2004-05-14 | 2007-02-27 | Medeikon Corporation | Low coherence interferometry utilizing phase |
US20070055117A1 (en) * | 2004-05-14 | 2007-03-08 | Alphonse Gerard A | Low coherence interferometry utilizing phase |
US7190464B2 (en) | 2004-05-14 | 2007-03-13 | Medeikon Corporation | Low coherence interferometry for detecting and characterizing plaques |
US20050254059A1 (en) * | 2004-05-14 | 2005-11-17 | Alphonse Gerard A | Low coherence interferometric system for optical metrology |
US7242480B2 (en) | 2004-05-14 | 2007-07-10 | Medeikon Corporation | Low coherence interferometry for detecting and characterizing plaques |
US20050254060A1 (en) * | 2004-05-14 | 2005-11-17 | Alphonse Gerard A | Low coherence interferometry for detecting and characterizing plaques |
US7486402B2 (en) * | 2004-10-04 | 2009-02-03 | Kabushiki Kaisha Topcon | Optical image measuring apparatus |
US20060072118A1 (en) * | 2004-10-04 | 2006-04-06 | Kabushiki Kaisha Topcon | Optical image measuring apparatus |
US7330270B2 (en) * | 2005-01-21 | 2008-02-12 | Carl Zeiss Meditec, Inc. | Method to suppress artifacts in frequency-domain optical coherence tomography |
US20060171503A1 (en) * | 2005-01-21 | 2006-08-03 | O'hara Keith E | Method to suppress artifacts in frequency-domain optical coherence tomography |
US8405834B2 (en) | 2005-01-21 | 2013-03-26 | Massachusetts Institute Of Technology | Methods and apparatus for optical coherence tomography scanning |
US20060187462A1 (en) * | 2005-01-21 | 2006-08-24 | Vivek Srinivasan | Methods and apparatus for optical coherence tomography scanning |
US20110134394A1 (en) * | 2005-01-21 | 2011-06-09 | Massachusetts Institute Of Technology | Methods and apparatus for optical coherence tomography scanning |
US7884945B2 (en) * | 2005-01-21 | 2011-02-08 | Massachusetts Institute Of Technology | Methods and apparatus for optical coherence tomography scanning |
US20070291276A1 (en) * | 2005-02-04 | 2007-12-20 | Carl Zeiss Meditec Ag | Device for Determining the Position of Spaced-Apart Areas in Transparent and/or Diffuse Objects |
US7656537B2 (en) * | 2005-02-04 | 2010-02-02 | Carl Zeiss Meditec Ag | Device for determining the position of spaced-apart areas in transparent and/or diffuse objects |
US20070278389A1 (en) * | 2006-06-02 | 2007-12-06 | Mahesh Ajgaonkar | Multi-channel low coherence interferometer |
US7488930B2 (en) | 2006-06-02 | 2009-02-10 | Medeikon Corporation | Multi-channel low coherence interferometer |
US7798647B2 (en) | 2007-09-18 | 2010-09-21 | Carl Zeiss Meditec, Inc. | RNFL measurement analysis |
US8128229B2 (en) | 2007-09-18 | 2012-03-06 | Carl Zeis Meditec, Inc. | RNFL measurement analysis |
US20090073387A1 (en) * | 2007-09-18 | 2009-03-19 | Meyer Scott A | Rnfl measurement analysis |
US20110063573A1 (en) * | 2007-09-18 | 2011-03-17 | Carl Zeiss Meditec, Inc. | Rnfl measurement analysis |
US8896833B2 (en) * | 2009-01-15 | 2014-11-25 | Centre National De La Recherche Scientifique-Cnrs | Device and method for determining a piece of polarization information and polarimetric imaging device |
US20110292389A1 (en) * | 2009-01-15 | 2011-12-01 | Centre National De La Recherche Scientifique-Cnrs | Device and Method for Determining a Piece of Polarisation Information and Polarimetric Imaging Device |
US10485422B2 (en) | 2009-02-19 | 2019-11-26 | Manish Dinkarrao Kulkarni | System and method for imaging subsurface of specimen |
US9046337B2 (en) | 2010-12-30 | 2015-06-02 | Volcano Corporation | Integrated OCT detector system with transimpedance amplifier |
US8437007B2 (en) * | 2010-12-30 | 2013-05-07 | Axsun Technologies, Inc. | Integrated optical coherence tomography system |
US10488177B2 (en) | 2010-12-30 | 2019-11-26 | Axsun Technologies, Inc. | Optical coherence tomography (OCT) system having integrated detector and analysis systems |
US20120170046A1 (en) * | 2010-12-30 | 2012-07-05 | Axsun Technologies, Inc. | Integrated Optical Coherence Tomography System |
US9366885B2 (en) | 2011-06-28 | 2016-06-14 | Medlumics S.L. | Integrated delay line for optical coherence tomography |
CN103917153A (en) * | 2011-06-28 | 2014-07-09 | 梅德路米克斯有限公司 | Integrated delay line for optical coherence tomography |
CN103917153B (en) * | 2011-06-28 | 2016-08-17 | 梅德路米克斯有限公司 | Integrated delay line for optical coherence tomography |
EP2725966A1 (en) * | 2011-06-28 | 2014-05-07 | Medlumics S.L. | Integrated delay line for optical coherence tomography |
EP2725966B1 (en) * | 2011-06-28 | 2021-11-17 | Medlumics S.L. | Integrated delay line for optical coherence tomography |
US9696136B2 (en) | 2013-09-25 | 2017-07-04 | Carl Zeiss Meditec, Inc. | Methods and systems for modifying second-order chromatic dispersion in optical coherence tomographic systems |
WO2015044232A1 (en) | 2013-09-25 | 2015-04-02 | Carl Zeiss Meditec Ag | Methods and systems for modifying second-order chromatic dispersion in optical coherence tomographic systems |
US11520164B2 (en) | 2014-01-31 | 2022-12-06 | Magic Leap, Inc. | Multi-focal display system and method |
US10317690B2 (en) | 2014-01-31 | 2019-06-11 | Magic Leap, Inc. | Multi-focal display system and method |
US11150489B2 (en) | 2014-01-31 | 2021-10-19 | Magic Leap, Inc. | Multi-focal display system and method |
US10254536B2 (en) | 2015-07-20 | 2019-04-09 | Magic Leap, Inc. | Collimating fiber scanner design with inward pointing angles in virtual/augmented reality system |
US11906739B2 (en) | 2015-10-05 | 2024-02-20 | Magic Leap, Inc. | Microlens collimator for scanning optical fiber in virtual/augmented reality system |
US11016298B2 (en) | 2015-10-05 | 2021-05-25 | Magic Leap, Inc. | Microlens collimator for scanning optical fiber in virtual/augmented reality system |
US10338391B2 (en) | 2015-10-06 | 2019-07-02 | Magic Leap, Inc. | Virtual/augmented reality system having reverse angle diffraction grating |
US11662585B2 (en) | 2015-10-06 | 2023-05-30 | Magic Leap, Inc. | Virtual/augmented reality system having reverse angle diffraction grating |
US10935792B2 (en) | 2015-10-06 | 2021-03-02 | Magic Leap, Inc. | Virtual/augmented reality system having reverse angle diffraction grating |
US11317064B2 (en) | 2016-01-20 | 2022-04-26 | Magic Leap, Inc. | Polarizing maintaining optical fiber in virtual/augmented reality system |
US20170208297A1 (en) * | 2016-01-20 | 2017-07-20 | Magic Leap, Inc. | Polarizing maintaining optical fiber in virtual/augmented reality system |
JP2021165849A (en) * | 2016-01-20 | 2021-10-14 | マジック リープ, インコーポレイテッドMagic Leap, Inc. | Polarizing maintaining optical fiber in virtual/augmented reality system |
US10587848B2 (en) * | 2016-01-20 | 2020-03-10 | Magic Leap, Inc. | Polarizing maintaining optical fiber in virtual/augmented reality system |
JP2019511734A (en) * | 2016-01-20 | 2019-04-25 | マジック リープ, インコーポレイテッドMagic Leap,Inc. | Polarization maintaining optical fiber in virtual and augmented reality systems |
US10555669B2 (en) | 2016-11-09 | 2020-02-11 | Amo Wavefront Sciences, Llc | Optical coherence tomography systems and methods with dispersion compensation |
US11193754B2 (en) | 2018-05-23 | 2021-12-07 | Haag-Streit Ag | OCT system and OCT method |
EP3797256B1 (en) * | 2018-05-23 | 2022-04-27 | Haag-Streit Ag | Oct system and oct method |
US11236986B2 (en) | 2018-05-23 | 2022-02-01 | Haag-Streit Ag | OCT system and OCT method |
US10705353B1 (en) * | 2018-12-18 | 2020-07-07 | Facebook Technologies, Llc | Waveguide with coherent interference mitigation |
US10942378B2 (en) * | 2018-12-18 | 2021-03-09 | Facebook Technologies, Llc | Waveguide with coherent interference mitigation |
Also Published As
Publication number | Publication date |
---|---|
US6175669B1 (en) | 2001-01-16 |
AU3120099A (en) | 1999-10-18 |
WO1999049780A1 (en) | 1999-10-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6385358B1 (en) | Birefringence insensitive optical coherence domain reflectometry system | |
US6992776B2 (en) | Method for studying a sample and optical interferometer for doing the same | |
US7126693B2 (en) | Simple high efficiency optical coherence domain reflectometer design | |
US6384915B1 (en) | Catheter guided by optical coherence domain reflectometry | |
EP0883793B1 (en) | Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope | |
US6900943B2 (en) | Optical amplification in coherent optical frequency modulated continuous wave reflectometry | |
US7995210B2 (en) | Devices and arrangements for performing coherence range imaging using a common path interferometer | |
RU2242710C2 (en) | Method and device for building object image and device for delivering low coherence optical radiation | |
US7263394B2 (en) | Coherence-gated optical glucose monitor | |
US7728983B2 (en) | Diffraction grating based interferometric systems and methods | |
US7705992B2 (en) | Optical coherence tomography system | |
US8964017B2 (en) | Optical tissue imaging based on optical frequency domain imaging | |
US20070109553A1 (en) | Polarization-sensitive common path optical coherence reflectometry/tomography device | |
WO1997032182A9 (en) | Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope | |
US20120300216A1 (en) | Integrated Optical Coherence Analysis System | |
US20080030740A1 (en) | Optical Measurements of Properties in Substances Using Propagation Modes of Light | |
US20030020922A1 (en) | Systems and methods for processing signals from an interferometer by an ultrasound console | |
WO2006041997A2 (en) | Cross-sectional mapping of spectral absorbance features | |
US20070109554A1 (en) | Polarization sensitive optical coherence device for obtaining birefringence information | |
EP1639331B1 (en) | Measurements of optical inhomogeneity and other properties in substances using propagation modes of light | |
EP1253398A1 (en) | Optical interferometer (variants) | |
EP2936241B1 (en) | Power-efficient optical buffering using a polarisation-maintaining active optical switch | |
Zhang et al. | Determination of birefringence and absolute optic axis orientation using polarization-sensitive |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: CALIFORNIA, THE REGENTS OF THE UNIVERSITY, CALIFOR Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:EVERETT, MATTHEW J.;REEL/FRAME:010490/0758 Effective date: 19991217 Owner name: REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE, CALI Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:EVERETT, MATTHEW J.;REEL/FRAME:010490/0758 Effective date: 19991217 |
|
AS | Assignment |
Owner name: U.S. DEPARTMENT OF ENERGY, CALIFORNIA Free format text: CONFIRMATORY LICENSE;ASSIGNOR:CALIFORNIA, UNIVERSITY OF;REEL/FRAME:010946/0312 Effective date: 20000501 |
|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
FPAY | Fee payment |
Year of fee payment: 4 |
|
AS | Assignment |
Owner name: LAWRENCE LIVERMORE NATIONAL SECURITY LLC, CALIFORN Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;REEL/FRAME:021217/0050 Effective date: 20080623 |
|
FEPP | Fee payment procedure |
Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY Free format text: PAT HOLDER NO LONGER CLAIMS SMALL ENTITY STATUS, ENTITY STATUS SET TO UNDISCOUNTED (ORIGINAL EVENT CODE: STOL); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
FPAY | Fee payment |
Year of fee payment: 8 |
|
FPAY | Fee payment |
Year of fee payment: 12 |