US6167299A - Method for recording skin galvanic reactions and device for realizing the same - Google Patents

Method for recording skin galvanic reactions and device for realizing the same Download PDF

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US6167299A
US6167299A US09/194,352 US19435299A US6167299A US 6167299 A US6167299 A US 6167299A US 19435299 A US19435299 A US 19435299A US 6167299 A US6167299 A US 6167299A
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pulse
derivative
unit
input
signal
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Leonid Arkad'evich Galchenkov
Valery Vasiljevich Dementienko
Lidyja Georgievna Koreneva
Andrey Genrikhovich Markov
Vjacheslav Markovich Shakhnarovich
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Zakrytoe Aktsionernoe Obschestvo Neurocom
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Zakrytoe Aktsionernoe Obschestvo Neurocom
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • A61B5/7207—Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal of noise induced by motion artifacts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0531—Measuring skin impedance
    • A61B5/0533—Measuring galvanic skin response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235—Details of waveform analysis
    • A61B5/7239—Details of waveform analysis using differentiation including higher order derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/06—Electrodes for high-frequency therapy

Definitions

  • the invention relates to the field of medicine and medical engineering, in particular to methods and devices for diagnostics of the status of an alive organism basing on skin electrical conductivity and can be used in experimental and clinical medicine, as well as in psychophysiology, pedagogics and sports medicine.
  • GSR galvanic skin reaction
  • the known methods of GSR monitoring include imposing on an subject's skin of a pair of electrodes connected to a source of a probing current and a monitoring device for the current in the circuit comprising electrodes and the source of current.
  • the response occurs when sweat glands excrete a secret and momentary pulses of electrical current arise in the circuit. Such pulses are generated either spontaneously, or owing to stress or another stimulus (A. A. Aldersons, Mechanisms of Electrodermal Reactions, Riga, "Zinatne", 1985, pp. 59-63).
  • the known devices for GSR monitoring include a source of electric current connected to electrodes, an electric signal monitoring unit, and a signal processing unit.
  • the signal processing consists in detection of the phasic component of EDA on the background of EDA tonic component. This can be embodied, for example, in the unit using a bridge circuit and a series of direct-current amplifiers with individual zero setting.
  • the value of the tonic component (hereinafter referred to as the trend) is calculated by an analog method, and this is further subtracted from the signal. This value is also used to adjust the base line of graph plotter to zero (U.S. Pat. No. 4,331,160, ZITO, 1982).
  • the comparative level of the phasic component of the EDA with respect to the trend is determined by a circuit comprising highpass and lowpass filters at the outputs of respective amplifiers, as well as a dividing circuit.
  • the method requires fastening two electrodes on the body of a subject, application of an electrical voltage to these, monitoring of time variation of the electric current flowing between electrodes and monitoring of the current pulses in the frequency band peculiar to phasic component of EDA.
  • the prototype of the device for galvanic skin reactions monitoring is the device implementing the above method (SU, A1, 1567427).
  • This device comprises electrodes with a means of their fastening to the skin these electrodes being connected to the input unit, a means for signal discrimination in frequency bands of phasic and tonic components of EDA, a means for detecting EDA phasic component pulses, a means for suppression of pulse interference, and a monitoring unit.
  • the abovementioned method and device are not free from interference brought about by the subject's motions (artifacts) superimposed onto GSR signals temporal sequence and similar to pulses of the EDA phasic component.
  • artifacts could be, for example, brought about by uncontrollable movements of the subject in the course of registration (so-called artifacts of movement).
  • noises due to variation of contact resistance between electrodes and the person's skin.
  • the abovementioned interference, including artifacts of movement can feature characteristic frequencies comparable to those of a phasic component of EDA, which makes their revealing and consideration a distinct problem.
  • An object of the present invention is development of a method of GSR monitoring and of a device for its implementation free from interference caused by artifacts of a person's movements as well as from interference brought about by non-biological causes (technogenic and atmospheric electrical discharges and equipment drift). This object is achieved without employment of any additional devices similar to those described in the abovementioned work of R.NICULA.
  • the information on interference is extracted directly from the GSR signal, and the claimed technique relies upon the detailed analysis of the shape of each electrical pulse of the sequence of pulses arriving from electrodes.
  • the pulse of the EDA phasic component is known to be a spontaneous momentary increase in skin conductivity followed by the subsequent return to the initial level.
  • Such a pulse possesses a specific asymmetry in the shape, namely, a steep leading edge and a more soft-sloped trailing edge (see “Principles of Psychophysiology. Physical, Social, And Inferential Elements".--Ed. John T. Cacioppo and Louis G. Tassinary.--Cambridge University Press, 1990, p.305).
  • differentiation of the input signal logarithm is performed (for example, by means of an analog differentiation).
  • the method of the present invention includes fastening of two electrodes on the body of a subject, feeding of the dc electric voltage to said electrodes, monitoring of time variation of the electrical current flowing between these electrodes and monitoring of electric current pulses in the frequency band of the phasic component of EDA.
  • the improvement brought about by the claimed method consists in analyzing of the shape of each pulse in the sequence of pulses of electric current in the frequency band of phasic component of EDA.
  • the signal is recorded as the time derivative of the logarithm of electric current numerical value; further, the value of the trend brought about by signal variation in the frequency band of tonic component of EDA, is determined; and the value of the first derivative is adjusted through subtraction of the trend value from it.
  • the second derivative in time of the logarithm of electric current numerical value is determined, the onset of said signal pulse being determined as the moment of said second derivative exceeding a threshold value, and then conformity of the pulse shape to certain preset criteria is verified. Should this conformity exist, the analyzed pulse is classified as a pulse of the EDA phasic component, in case of lack of such conformity the pulse is put down to artifacts.
  • the trend value could be determined as the first derivative average over the time interval characteristic for the tonic component, basically 30 to 120 sec. Besides, the trend value could be determined as the first derivative average over the time interval 1 to 2 sec., provided first and second derivative values being less than certain preset threshold values over this time interval.
  • the onset of the first derivative pulse could be considered the moment when the second derivative exceeds the threshold value by at least 0.2%.
  • the pulse shape it is expedient to register the maximum (f MAX ) and the minimum (f MIN ) values of the first time derivative minus the trend value, their ratio r, and the time interval (t x ) between the minimum and the maximum of the first derivative.
  • the moments of the first derivative achieving its maximum and minimum values are determined as the moments of the second derivative sign change.
  • the criteria of the analyzed pulse belonging to EDA phasic component signal could be the following inequalities (for the filtered signal):
  • the above attributes of the claimed method essential for achievement of the object of the invention provide for achievement of the technological result, namely, enhancing of an electronic interference immunity in galvanic skin reaction monitoring in conditions of real interference of various origins and artifacts of movement of the subject himself.
  • the means for implementation of the present method described hereinafter can be embodied via either hardware or software, their essence being clarified from the description given below.
  • the device for monitoring of GSR comprises an input unit with electrodes connected to it and a means for their fastening to a subject's body, a means for suppression of pulse interference, a means for discrimination of signals in frequency bands of phasic component of EDA, a means for detecting pulses of phasic component of EDA, and a monitoring unit.
  • the improvement consists in the assembly comprising the means for signal discrimination in the frequency band of EDA phasic component and the means for detection of pulses of said component being embodied as the assembly comprising a unit for conversion of the logarithm of the input signal into the first and the second derivatives in time and a pulse shape analysis unit.
  • the unit for conversion of the logarithm of the input signal into the first and the second derivatives in time and the pulse shape analysis unit are connected serially to the input unit, the output of the pulse shape analysis unit being connected to the monitoring unit input.
  • the device can be embodied in such a way that the assembly comprising the means for suppression of pulse interference, the means for signal discrimination in the frequency band of EDA phasic component and the means for detection of pulses of said component is embodied as an assembly comprising a lowpass filter, a unit for conversion of the logarithm of the input signal into the first and the second derivatives in time, and a pulse shape analysis unit.
  • the input unit could comprise a stabilized dc electric voltage source and a resistor connected in series to electrodes, a logarithmic amplifier with a differential input stage, the resistor shunting the logarithmic amplifier inputs.
  • the unit for conversion of the logarithm of the input signal into the first and the second derivatives in time could be embodied as a first and a second differentiators and a second lowpass filter, the output of the first differentiator being connected to the input of the second differentiator and of the second lowpass filter, outputs of the latters being the outputs of the unit for conversion of the logarithm of the input signal into the first and the second derivatives in time.
  • the shape analysis unit can include a means for determination of the maximum conductivity variation rate at leading and trailing edges of the pulse being analyzed, a means for evaluation of its shape asymmetry, a means for determination of pulse width, a means for comparison of said values with the preset limits for generation of the signal indicating belonging of the pulse being analyzed to EDA phasic component.
  • a GSR monitoring computer-based device which performs digital signal processing.
  • Such a device comprises an input unit with electrodes connected to it and a means for their fastening to a subject's body and a computer.
  • the input unit comprises a stabilized dc electric voltage source, a resistor, an amplifier with a differential input stage, an analog-to-digital converter.
  • the stabilized dc electric voltage source is connected in series to the resistor and the electrodes, said resistor shunting the inputs of said amplifier, the output of which is connected to the input of the analog-to-digital converter, the digital output of which being connected to the digital input of the computer.
  • suppression of pulse interference, discrimination of signals in frequency bands of phasic component of EDA, detecting pulses of phasic component of EDA, and monitoring of said pulses are implemented as a computer program.
  • the technological result i.e. enhancement of reliability in discrimination of EDA phasic component pulses does not follow obviously from the prior art information.
  • the inventors claim not knowing any sources of the information disclosing the employed technique of signal shape analysis enabling one to discriminate the valid EDA phasic component pulses from artifacts, including those caused by movements of the subject. The above allows one to consider the invention satisfying the condition of the invention idea being not obvious.
  • FIG. 1 is the flowchart of the device for galvanic skin reactions monitoring in compliance with the present invention
  • FIG. 2 shows the real example of the initial signal (a) shape and the results of its processing by the device under the invention (b, c, d);
  • FIG. 3 is the hardware implementation of the pulse shape analysis unit
  • FIG. 4 shows waveforms explaining operation of the pulse shape analysis unit
  • FIG. 5 shows the example of implementation of the synchronization unit incorporated into pulse shape analysis unit
  • FIG. 6 shows the example of computer-based implementation of the device employing digital processing of the signal.
  • the device for GSR monitoring (FIG. 1) includes the input unit 1 connected to the electrodes 2, 3 for application onto the skin of the subject 4.
  • the electrodes may be embodied in various versions, for example as two rings, a wrist bracelet and a ring, a bracelet with two electrical contacts. The only requirement to these is that the electrodes should provide a stable electrical contact with the subject skin.
  • the electrodes 2, 3 are connected to the stabilized voltage source 5 through the resistor R (6), said resistor being connected to the input of the differential logarithmic amplifier 7, the output of which is the output of the input unit 1, and is connected to the means for pulse interference suppression 8, for example, to the input of one or more lowpass filters connected serially.
  • a single filter 8 is employed, the output of which is connected to the input of the first differentiator 9.
  • the output of the first differentiator 9 is connected to the input of the second differentiator 10, the output of which is connected to the input 11 of pulse shape analyzer unit 12.
  • the output of the first differentiator 9 is connected directly to the unit 12 through the input 13, and to the other input 15 of pulse shape analyzer unit 12 through the second lowpass filter 14.
  • the signal from the output of said second lowpass filter 14 is used in the unit 12 for compensation of EDA tonic component.
  • the cut-off frequency of the lowpass filter 8 constitutes ca.1 Hz, and the cut-off frequency of the second lowpass filter 14--about 0.03 Hz, which corresponds to higher limits of frequency bands of EDA phasic and tonic components.
  • the output of the pulse shape analyzer unit 12 is connected to the monitoring unit 16.
  • characteristic parameters of the signal are compared to allowable limits. These characteristic parameters include:
  • Width t x of the pulse determined as the time interval between the moments of achieving by the first derivative of its maximum and minimum values
  • Ratio of absolute values of the first derivative (minus a trend) in the maximum and the minimum: r (f MAX )
  • m 1 , m 2 are minimum and maximum allowable values of the first derivative (minus the trend) at the maximum, %/s;
  • m 3 , m 4 are minimum and maximum allowable values of the first derivative (minus the trend) at the minimum, %/s;
  • t 1 , t 2 are minimum and maximum time intervals between extrema of the first derivative, s;
  • r 1 , r 2 are minimum and maximum values of the ratio r.
  • FIG. 2 shows the example of processing of a real GSR signal.
  • (I meas ) at the output of the logarithmic amplifier 7 plots (b) and (c)-- the first (U') and the second (U") derivatives of the plot (a) signal.
  • the numerical values of the signal derivatives U' and U" are in units % Is and %/s 2 , respectively.
  • the plot (d) on the same FIG. 2 is the result of GSR signal discrimination from the background of the trend and of interference carried out in compliance with the present invention.
  • the labels S 1 and S 2 denote signals corresponding to the time of phasic component pulses occurrence.
  • Verification of pulse shape conformity with the specified four criteria (*) is performed by the pulse shape analysis unit 12.
  • the trend value can be defined as an average value of the first derivative over the time interval characteristic for the tonic component, basically 30 to 120 s.
  • the trend value can be defined as an average value of the first derivative over the time interval 1 to 2 s, provided the values of the first and the second derivatives are less than the given threshold values during this interval of time.
  • the trend is determined more accurately, however in case of abundance of interference the abovementioned conditions can be not valid for a long time period. In this case the trend should be calculated by the first method.
  • FIG. 3 shows an example of hardware implementation of the unit 12. In this variant the trend is determined by the averaged value of the first derivative over the time interval of 30 sec.
  • FIG. 4 demonstrates the waveforms explaining operation of individual components of this unit.
  • the unit 12 has three inputs, vis. 11, 13 and 15.
  • the input 11 to which the second derivative U" signal comes, is the signal input of two comparators 17 and 18, the reference input of the latter being fed with the zero potential.
  • the inputs 13 and 15 are the inputs of the differential amplifier 19, the output of which is connected to signal inputs of sampling/storage circuits 20 and 21.
  • the outputs of comparators 17, 18 are connected to the inputs of the synchronization unit 22, to inputs 23 and 24, respectively.
  • the output 25 of the unit 22 is connected to the clock input of the sampling/storage circuit 20 and to the triggering input of the sawtooth generator 26.
  • the output 27 is connected to the clock input of the sampling/storage circuit 21.
  • the outputs of the sampling/storage circuits 20, 21 and of the sawtooth generator 26 are connected to the inputs of the comparator circuits 29, 30 and 31.
  • the outputs of the circuits 20 and 21 are connected to the inputs of the analog divider 32, the output of which is connected to the input of the comparator circuit 33.
  • the outputs of the circuits 29, 30, 31, 33 are connected to logic inputs of the "AND” circuit 34, vis. 35, 36, 37, 38.
  • the output 28 of the synchronization circuit 22 is connected to the gate input 39 of the "AND” circuit 34.
  • the comparator 17 has the reference voltage input V S1 setting the threshold value for the second derivative exceeding of which triggers the analysis of the pulse shape.
  • the reference inputs of the comparator circuits 29, 30, 31, 33 are connected to reference voltage sources (not shown in the figure) which determine the allowable limits for the selected parameters. Indexes in the equation symbols of these voltages (V T1 , V T2 ; V M1 , V M2 ; V R1 , V R2 ; V M3 , V M4 ) correspond to the abovementioned limits, within which the values of the characteristic parameters of the pulse shape (see inequalities (*)) should be confined. Should this be the case, a short logic "1" pulse is generated at the output 40 of the circuit 34.
  • the diagram a) shows the example of a single pulse at the output of the logarithmic amplifier 7.
  • the first derivative signal to the input 13 (diagram b)
  • the first derivative signal averaged over 30 s to the input 15 (diagram c)
  • the averaging time is chosen the least corresponding to the frequency range of EDA tonic component. This results in the voltage at the output of the differential amplifier 19 of the value U' corresponding to the first derivative of the input signal logarithm compensated for the trend.
  • the value of U' is the relative value of voltage increment per one second expressed in % with respect to the value of the trend (see FIG. 4, b). It is this signal that is analyzed by the remaining part of the circuit. Timing of unit 12 components is carried out by the synchronization circuit 22 as follows.
  • the signal from the output of the comparator 17 is a positive voltage step arising at voltage from the differentiating circuit 10 output exceeding the threshold value V S1 (FIG. 4, c).
  • the numerical value of a threshold voltage V S1 in volts is selected so that it corresponds to second derivative variation by at least 0.2%, which has been determined experimentally.
  • This positive voltage step (FIG. 4, d) is the triggering gate for the synchronization circuit 22.
  • the comparator 18 (see FIG.
  • the first pulse is also fed to the input of the sawtooth generator 26, which, on arrival of the gate, produces the linearly increasing voltage (FIG. 4, j).
  • the signal from the output of the sawtooth generator 26 is fed to the input of the comparator circuit 29.
  • the output signal from the circuit 20 is fed to the comparator circuit input 30.
  • the signal from the circuit 21 output is fed to the circuit 31.
  • the signals from the outputs of the circuits 20, 21 are fed to inputs "A" and "B" of the analog divider 32.
  • the signal from analog divider 32 output proportional to the ratio of input voltages U A /U B is fed to the input of the comparator circuit 33.
  • the comparator circuits (29-31, 33) can be embodied by any of the traditional methods. They produce a logic "1" signal provided that the input voltage is confined in a range set by two reference voltages.
  • All internal gate signals are provided by the synchronization circuit 22, which can be embodied, for example, as follows (see FIG. 5).
  • the circuit 22 has two inputs: 23 and 24.
  • the input 23 is connected to the S-input of the RS-flip-flop 41 which is set to the "1" status by the positive edge from the comparator 17 (FIG. 4, d), i.e. at exceeding of the threshold level by the second derivative U" value.
  • the output Q of the flip-flop 41 is connected to the inputs of the logic "AND” circuits 42 and 43, clearing passage for signals from the flip-flop 44 and the inverter 45 through these circuits.
  • the signal from the comparator 18 (FIG. 4, e) is fed.
  • the negative signal step from the input 24 is inverted by the inverter 45 and through the circuit 42 arrives to another monostable 46 which produced a gate pulse at the output 25 (see FIG. 4, h).
  • the positive signal step from the input 24 sets the flip-flop 44 to the "1" state, which in its turn triggers the monostable 47 which produces a short positive pulse.
  • This gate pulse is fed to the output 27 of the synchronization circuit (FIG. 4, f).
  • the same pulse is fed to the input of the inverter 48, the output of which is connected to the input of the monostable 49.
  • the circuit 49 is triggered by the trailing edge of the pulse from the output 47 and produces the third short gate pulse (see FIG. 4, k).
  • This pulse is fed to the output 28 and is also used to reset RS-flip-flops 41 and 44, for which purpose it is fed to their "R"--inputs. After passage of this pulse the synchronization circuit 22 is again ready for operation until arrival of the next signal to the input 23.
  • a short logic "1" pulse is produced at the output 40 of the shape analysis unit 12 (see FIG. 3), provided the analyzed parameters are confined within the preset limits.
  • the labels S 1 and S 2 denote these very pulses; for visualization purposes they are superimposed on the plots of the first and the second derivatives of the analyzed signal.
  • FIG. 6 shows the example of computer-based implementation of the device employing digital processing of the signal.
  • the device includes the input unit 100 connected to the electrodes 2, 3 for imposing onto the skin of a subject 4, and the computer 52.
  • the electrodes are connected through the resistor R (6) to the stabilized source 5 of the dc electric voltage.
  • the signal from the resistor 6 is fed to the operational amplifier 50 with high input impedance and low output impedance said amplifier working in a linear mode. From the output of the amplifier 50 the signal is fed to the input of the standard 16-digit analog-to-digital converter 51 installed in the expansion slot of the IBM-compatible computer 52. Taking of logarithm and all subsequent analysis of the signal are performed digitally.
  • the first and second derivatives of the value 100 ⁇ In (I meas ) are calculated.
  • the trend value is defined as the average value of first derivative over the period 30 to 120 s.
  • the claimed method of GSR monitoring and the two versions of the device for its implementation enable to eliminate the interference brought about by artifacts the subject's movements, as well as the interference caused by non-biological factors increasing thereby the validity and reliability of the measurements.
  • the described method and devices can be used in various medical and psychophysiological researches where one of measured parameters is the skin electrical conductivity. These are, for example: training devices with skin resistance feedback for development of skills of relaxation and concentration of attention; system of professional selection, etc. Besides, the claimed invention can be applied, for example, for assessment of alertness level of a vehicle driver in real conditions featured by presence of numerous interferences.
  • the implementation of the devices can be easily carried out with a standard component base.
  • the signal digital processing device version can be implemented on the basis of any personal computer, as well as employing any microcontroller or one-chip microcomputer.
  • Communication of the measuring part and signal processing devices can be carried out by any of the known methods, both wire and wireless, for example, using a radiochannel or IR-channel.
US09/194,352 1996-03-28 1997-05-22 Method for recording skin galvanic reactions and device for realizing the same Expired - Fee Related US6167299A (en)

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RU96-110526 1996-03-28
RU96110526A RU2107460C1 (ru) 1996-05-28 1996-05-28 Способ регистрации кожно-гальванических реакций и устройство для его осуществления
PCT/RU1997/000162 WO1997045162A1 (fr) 1996-05-28 1997-05-22 Procede d'enregistrement des reactions galvaniques sur la peau et dispositif de mise en oeuvre de ce procede

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