US5983900A - Wrinkle removal - Google Patents
Wrinkle removal Download PDFInfo
- Publication number
- US5983900A US5983900A US08/919,472 US91947297A US5983900A US 5983900 A US5983900 A US 5983900A US 91947297 A US91947297 A US 91947297A US 5983900 A US5983900 A US 5983900A
- Authority
- US
- United States
- Prior art keywords
- layer
- laser
- dermal
- dermal layer
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
- A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00747—Dermatology
- A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00452—Skin
- A61B2018/0047—Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
Definitions
- the present invention relates to a method of removing wrinkles from a superficial area of mammalian skin tissue.
- a CO 2 laser which operates in the infra-red region of the spectrum, is used, the radiation being totally absorbed in a thin layer of surface tissue, primarily because of the wavelength's high rate of absorption in water.
- Stage 1--Skin Resurfacing The purpose of the first stage is to remove a thin layer of tissue from a superficial area of mammalian skin tissue.
- the skin is irradiated by the laser which, as mentioned above, deposits its energy in a thin layer at the surface (approx 30 ⁇ m in thickness).
- the application of the laser radiation to the tissue is by computer controlled scanner designed to ensure that one pass of the radiation removes one "layer" of tissue only. In this way, damage is limited to the epidermis only.
- This process quickly ablates the surface layer removing the surface skin and with it any skin blemishes. The process is straightforward and does not demand a great deal of operator skill.
- the surface skin immediately starts to replace itself and this allows the skin to return to normal in about 3 to 5 days.
- Stage 2--Wrinkle Removal After the skin surface has been resurfaced, the operator will, typically, apply further "passes" of the laser, thereby removing further layers of mammalian skin tissue, each layer being of the order of 30 ⁇ m thick. Typically, around three or four further passes will complete the wrinkle removal procedure. This treatment therefore produces a controlled second degree burn. The skin barrier to the outside world is removed and therefore, there is a danger of infection.
- the laser induces denaturing of the collagen in the dermis, and the formation of cross links, which results in a tightening effect stretching the skin, reducing or removing the wrinkles (it is thought that the thermal threshold for this effect is a temperature of 70° C.);
- the skin-resurfacing and wrinkle removal procedure outlined above is considered by many experts in the field as a significant improvement over previously used surgical methods.
- the procedure uses the laser's ability to deliver high energy density at the surface of tissue and hence ablate the surface tissue in a well controlled manner.
- layer by layer is designed to damage the collagen and hence induce wrinkle removal.
- This second stage of the procedure is primitive; the skin weeps, scabs form and redness of the skin appears for many weeks.
- the laser can be used to modify that target selectively within an inhomogeneous volume of tissue.
- the desired target does not have a suitable chromophore of its own but exists in close proximity to another material which has such a chromophore which can be selectively targeted. Such interaction is called secondary selective interaction.
- the present invention provides a method of removing wrinkles from a superficial area of mammalian skin tissue.
- the dermal layer of the tissue is irradiated through the basal layer by radiation selected to be absorbed by a chromophore in the dermal layer such that collagen present in the dermal layer is heated, while the basal layer remains intact so as to substantially inhibit contact of the dermal layer with ambient air.
- the irradiation of the dermal layer in the method according to the invention is therefore such as to shrink the skin tissue without damage to the dermis (in other words, without causing second degree burns) because the barrier provided by the basal layer remains intact.
- the method according to the invention is non-invasive and can readily be performed by non-medical personnel.
- the irradiation may be by means of a source of visible or infra-red radiation (suitably filtered to remove deleterious ultra-violet radiation if necessary).
- the radiation may be incoherent or, more preferably, coherent (that is from a laser source).
- a laser source may be, for example, a dye laser, a ruby laser, or a semi-conductor laser. If a dye laser is used, its wavelength is preferably such that it is absorbed by oxyhemoglobin (as naturally occurring chromophore present in blood vessels in the dermis).
- the superficial area may be treated with an artificial chromophore which is absorbed into the dermal layer.
- Such an artificial chromophore may be applied to the epidermal layer in the form of a liposome-containing topical formulation. The chromophore may then permeate through the basal layer for delivery to the dermal layer.
- the pulses When a laser is used, it may be arranged to scan the superficial area and/or to irradiate the dermal layer in pulses. When the laser is in pulsed mode, the pulses typically have duration of 10 ⁇ sec to 10 msec (more preferably 100 ⁇ sec to 2 msec).
- Such epidermis removal may be effected mechanically (for example by abrasion), or by means of laser radiation.
- laser radiation is typically a scanner controlled CO 2 laser source.
- FIG. 1 is a schematic representation of the three outermost layers of mammalian skin tissue
- FIG. 2 is a schematic representation of partial removal of the epidermis (skin resurfacing), which is an optional step according to the invention
- FIG. 3 is a schematic illustration of the result of a prior art method of wrinkle removal, which is surgical because it involves full removal of the epidermis in a selected area and therefore exposure of the dermis and consequent second degree burning;
- FIG. 4 is a schematic illustration of the result of the method according to the invention, showing that the epidermis is partially intact and the basal layer fully intact.
- the basic skin structure of mammalian skin tissue comprises three layers, the outermost epidermis 1 which is adjacent to the basal layer 2 and then the dermis 3.
- prior art method of wrinkle removal results in complete removal of an area 5 of epidermis 1 and basal layer 2 by repeated exposure to CO 2 laser radiation. Partial removal of the dermis 3 also occurs, as represented by 6, leaving the dermis exposed to air. This causes a second degree burn which is slow to heal and a risk of infection.
- the method of wrinkle removal according to the invention results in partial removal of the epidermis 1 (this is an optional step as described in FIG. 2 above) and the basal layer 2 is left intact, such that the dermis 3 is not exposed to air.
- Laser radiation 7 is applied to the tissue and selectively absorbed by a chromophore in the dermis 3, heating the collagen and shrinking the skin hence removing the appearance of wrinkles.
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Electromagnetism (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Laser Surgery Devices (AREA)
- Radiation-Therapy Devices (AREA)
- Surgical Instruments (AREA)
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9618051.8A GB9618051D0 (en) | 1996-08-29 | 1996-08-29 | Wrinkle removal |
US08/919,472 US5983900A (en) | 1996-08-29 | 1997-08-28 | Wrinkle removal |
ZA9707751A ZA977751B (en) | 1996-08-29 | 1997-08-28 | Wrinkle removal. |
CA002265041A CA2265041C (en) | 1996-08-29 | 1997-08-29 | Wrinkle removal |
AU39511/97A AU3951197A (en) | 1996-08-29 | 1997-08-29 | Wrinkle removal |
EP97936817A EP0932431B1 (en) | 1996-08-29 | 1997-08-29 | Wrinkle removal |
PCT/GB1997/002322 WO1998008568A1 (en) | 1996-08-29 | 1997-08-29 | Wrinkle removal |
ES97936817T ES2218695T3 (es) | 1996-08-29 | 1997-08-29 | Eliminacion de arrugas. |
JP10511395A JP2000517211A (ja) | 1996-08-29 | 1997-08-29 | 皺の除去方法 |
NZ334910A NZ334910A (en) | 1996-08-29 | 1997-08-29 | Wrinkle removal by a visible or infra-red radiation means |
DE69728779T DE69728779T2 (de) | 1996-08-29 | 1997-08-29 | Entfernung von fältchen |
US09/263,422 US6443946B2 (en) | 1996-08-29 | 1999-03-05 | Apparatus for wrinkle removal |
US09/981,077 US20020045891A1 (en) | 1996-08-29 | 2001-12-27 | Wrinkle reduction |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9618051.8A GB9618051D0 (en) | 1996-08-29 | 1996-08-29 | Wrinkle removal |
US08/919,472 US5983900A (en) | 1996-08-29 | 1997-08-28 | Wrinkle removal |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/263,422 Continuation-In-Part US6443946B2 (en) | 1996-08-29 | 1999-03-05 | Apparatus for wrinkle removal |
US09/263,422 Continuation US6443946B2 (en) | 1996-08-29 | 1999-03-05 | Apparatus for wrinkle removal |
Publications (1)
Publication Number | Publication Date |
---|---|
US5983900A true US5983900A (en) | 1999-11-16 |
Family
ID=26309944
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/919,472 Expired - Lifetime US5983900A (en) | 1996-08-29 | 1997-08-28 | Wrinkle removal |
US09/263,422 Expired - Fee Related US6443946B2 (en) | 1996-08-29 | 1999-03-05 | Apparatus for wrinkle removal |
US09/981,077 Abandoned US20020045891A1 (en) | 1996-08-29 | 2001-12-27 | Wrinkle reduction |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/263,422 Expired - Fee Related US6443946B2 (en) | 1996-08-29 | 1999-03-05 | Apparatus for wrinkle removal |
US09/981,077 Abandoned US20020045891A1 (en) | 1996-08-29 | 2001-12-27 | Wrinkle reduction |
Country Status (11)
Country | Link |
---|---|
US (3) | US5983900A (xx) |
EP (1) | EP0932431B1 (xx) |
JP (1) | JP2000517211A (xx) |
AU (1) | AU3951197A (xx) |
CA (1) | CA2265041C (xx) |
DE (1) | DE69728779T2 (xx) |
ES (1) | ES2218695T3 (xx) |
GB (1) | GB9618051D0 (xx) |
NZ (1) | NZ334910A (xx) |
WO (1) | WO1998008568A1 (xx) |
ZA (1) | ZA977751B (xx) |
Cited By (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6113559A (en) * | 1997-12-29 | 2000-09-05 | Klopotek; Peter J. | Method and apparatus for therapeutic treatment of skin with ultrasound |
US6325769B1 (en) | 1998-12-29 | 2001-12-04 | Collapeutics, Llc | Method and apparatus for therapeutic treatment of skin |
US6340495B1 (en) * | 1997-12-16 | 2002-01-22 | Galderma Research & Development | Device including a chromophoric composition to be applied to the skin, a method of fabricating such a device, and uses therefor |
US20030040739A1 (en) * | 2001-08-21 | 2003-02-27 | Koop Dale E. | Enhanced noninvasive collagen remodeling |
US20030109787A1 (en) * | 2001-12-12 | 2003-06-12 | Michael Black | Multiple laser diagnostics |
US6702838B1 (en) | 2000-09-18 | 2004-03-09 | Lumenis Inc. | Method of treating hypotrophic scars enlarged pores |
US6808532B2 (en) | 2000-12-15 | 2004-10-26 | Dan E. Andersen | Laser treatment for reducing wrinkles |
US20050055070A1 (en) * | 2003-03-07 | 2005-03-10 | Gareth Jones | Method and device for treatment of skin conditions |
US20050141068A1 (en) * | 2003-12-31 | 2005-06-30 | Debenedictis Leonard C. | High speed, high efficiency optical pattern generator using rotating optical elements |
US20050259306A1 (en) * | 2003-12-31 | 2005-11-24 | Broome Barry G | Two-dimensional optical scan system using a counter-rotating disk scanner |
US7090670B2 (en) | 2003-12-31 | 2006-08-15 | Reliant Technologies, Inc. | Multi-spot laser surgical apparatus and method |
US20060184071A1 (en) * | 1997-12-29 | 2006-08-17 | Julia Therapeutics, Llc | Treatment of skin with acoustic energy |
US7282060B2 (en) | 2003-12-23 | 2007-10-16 | Reliant Technologies, Inc. | Method and apparatus for monitoring and controlling laser-induced tissue treatment |
US20080027328A1 (en) * | 1997-12-29 | 2008-01-31 | Julia Therapeutics, Llc | Multi-focal treatment of skin with acoustic energy |
US7372606B2 (en) | 2003-12-31 | 2008-05-13 | Reliant Technologies, Inc. | Optical pattern generator using a single rotating component |
US20080146970A1 (en) * | 2005-12-06 | 2008-06-19 | Julia Therapeutics, Llc | Gel dispensers for treatment of skin with acoustic energy |
USRE40403E1 (en) | 1998-06-11 | 2008-06-24 | Cynosure, Inc. | Method for non-invasive wrinkle removal and skin treatment |
US7413572B2 (en) | 2004-06-14 | 2008-08-19 | Reliant Technologies, Inc. | Adaptive control of optical pulses for laser medicine |
US20080214988A1 (en) * | 2000-12-28 | 2008-09-04 | Palomar Medical Technologies, Inc. | Methods And Devices For Fractional Ablation Of Tissue |
US20090054953A1 (en) * | 2004-08-05 | 2009-02-26 | Photo Therapeutics Limited | Phototherapeutic Method and Apparatus |
USRE42594E1 (en) | 1998-10-16 | 2011-08-02 | Reliant Technologies, Inc. | Tissue cooling rod for laser surgery |
US8367959B2 (en) | 1997-07-31 | 2013-02-05 | Miramar Labs, Inc. | Method and apparatus for treating subcutaneous histological features |
US8401668B2 (en) | 2007-04-19 | 2013-03-19 | Miramar Labs, Inc. | Systems and methods for creating an effect using microwave energy to specified tissue |
US8406894B2 (en) | 2007-12-12 | 2013-03-26 | Miramar Labs, Inc. | Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy |
US8469951B2 (en) | 2011-08-01 | 2013-06-25 | Miramar Labs, Inc. | Applicator and tissue interface module for dermatological device |
US8688228B2 (en) | 2007-04-19 | 2014-04-01 | Miramar Labs, Inc. | Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy |
US20140100489A1 (en) * | 2001-11-29 | 2014-04-10 | Palomar Medical Technologies, Inc. | Method and apparatus for delivering low power optical treatments |
US8915948B2 (en) | 2002-06-19 | 2014-12-23 | Palomar Medical Technologies, Llc | Method and apparatus for photothermal treatment of tissue at depth |
US9028536B2 (en) | 2006-08-02 | 2015-05-12 | Cynosure, Inc. | Picosecond laser apparatus and methods for its operation and use |
US9149331B2 (en) | 2007-04-19 | 2015-10-06 | Miramar Labs, Inc. | Methods and apparatus for reducing sweat production |
US9241763B2 (en) | 2007-04-19 | 2016-01-26 | Miramar Labs, Inc. | Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy |
US9351792B2 (en) | 2003-03-27 | 2016-05-31 | The General Hospital Corporation | Method and apparatus for dermatological treatment and fractional skin resurfacing |
US9780518B2 (en) | 2012-04-18 | 2017-10-03 | Cynosure, Inc. | Picosecond laser apparatus and methods for treating target tissues with same |
US20190008589A1 (en) * | 2017-07-06 | 2019-01-10 | Boston Scientific Scimed, Inc | Optical fibers and associated systems |
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US11418000B2 (en) | 2018-02-26 | 2022-08-16 | Cynosure, Llc | Q-switched cavity dumped sub-nanosecond laser |
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DE19823947A1 (de) * | 1998-05-28 | 1999-12-02 | Baasel Carl Lasertech | Verfahren und Vorrichtung zum oberflächlichen Erwärmen von Gewebe |
US7004933B2 (en) * | 1998-05-29 | 2006-02-28 | Light Bioscience L.L.C. | Ultrasound enhancement of percutaneous drug absorption |
US20060212025A1 (en) | 1998-11-30 | 2006-09-21 | Light Bioscience, Llc | Method and apparatus for acne treatment |
US9192780B2 (en) | 1998-11-30 | 2015-11-24 | L'oreal | Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders |
US6887260B1 (en) | 1998-11-30 | 2005-05-03 | Light Bioscience, Llc | Method and apparatus for acne treatment |
US6283956B1 (en) | 1998-11-30 | 2001-09-04 | David H. McDaniels | Reduction, elimination, or stimulation of hair growth |
US6936044B2 (en) * | 1998-11-30 | 2005-08-30 | Light Bioscience, Llc | Method and apparatus for the stimulation of hair growth |
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US7493645B1 (en) | 2000-10-27 | 2009-02-17 | Audiovox Corporation | Console with monitor and wireless receiver |
WO2002053050A1 (en) * | 2000-12-28 | 2002-07-11 | Palomar Medical Technologies, Inc. | Method and apparatus for therapeutic emr treatment of the skin |
US20030109860A1 (en) * | 2001-12-12 | 2003-06-12 | Michael Black | Multiple laser treatment |
US7056318B2 (en) * | 2002-04-12 | 2006-06-06 | Reliant Technologies, Inc. | Temperature controlled heating device and method to heat a selected area of a biological body |
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-
1996
- 1996-08-29 GB GBGB9618051.8A patent/GB9618051D0/en active Pending
-
1997
- 1997-08-28 ZA ZA9707751A patent/ZA977751B/xx unknown
- 1997-08-28 US US08/919,472 patent/US5983900A/en not_active Expired - Lifetime
- 1997-08-29 JP JP10511395A patent/JP2000517211A/ja active Pending
- 1997-08-29 CA CA002265041A patent/CA2265041C/en not_active Expired - Fee Related
- 1997-08-29 ES ES97936817T patent/ES2218695T3/es not_active Expired - Lifetime
- 1997-08-29 DE DE69728779T patent/DE69728779T2/de not_active Expired - Lifetime
- 1997-08-29 WO PCT/GB1997/002322 patent/WO1998008568A1/en active IP Right Grant
- 1997-08-29 NZ NZ334910A patent/NZ334910A/xx unknown
- 1997-08-29 EP EP97936817A patent/EP0932431B1/en not_active Expired - Lifetime
- 1997-08-29 AU AU39511/97A patent/AU3951197A/en not_active Abandoned
-
1999
- 1999-03-05 US US09/263,422 patent/US6443946B2/en not_active Expired - Fee Related
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2001
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Also Published As
Publication number | Publication date |
---|---|
DE69728779D1 (de) | 2004-05-27 |
ZA977751B (en) | 1998-03-20 |
GB9618051D0 (en) | 1996-10-09 |
US20010013349A1 (en) | 2001-08-16 |
CA2265041C (en) | 2002-07-02 |
DE69728779T2 (de) | 2005-04-28 |
NZ334910A (en) | 2000-01-28 |
US6443946B2 (en) | 2002-09-03 |
ES2218695T3 (es) | 2004-11-16 |
CA2265041A1 (en) | 1998-03-05 |
AU3951197A (en) | 1998-03-19 |
WO1998008568A1 (en) | 1998-03-05 |
EP0932431A1 (en) | 1999-08-04 |
JP2000517211A (ja) | 2000-12-26 |
EP0932431B1 (en) | 2004-04-21 |
US20020045891A1 (en) | 2002-04-18 |
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