US4909254A - Phototherapy of skin wounds - Google Patents

Phototherapy of skin wounds Download PDF

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Publication number
US4909254A
US4909254A US07086077 US8607787A US4909254A US 4909254 A US4909254 A US 4909254A US 07086077 US07086077 US 07086077 US 8607787 A US8607787 A US 8607787A US 4909254 A US4909254 A US 4909254A
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US
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Grant
Patent type
Prior art keywords
radiation
layers
wound
uv
filter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
US07086077
Inventor
Frank J. Wilkinson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ACT 1949
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION LIMESTONE AVENUE CAMPBELL AUSTRALIAN CAPITAL TERRITORY 2602 AUSTRALIAN A BODY CORP ESTABLISHED BY COMMONWEALTH SCIENCE AND INDUSTRY RESEARCH
Commonwealth Scientific and Industrial Research Organization (CSIRO)
Original Assignee
Commonwealth Scientific and Industrial Research Organization (CSIRO)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/0616Skin treatment other than tanning
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0635Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643Applicators, probes irradiating specific body areas in close proximity
    • A61N2005/0644Handheld applicators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0658Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0661Radiation therapy using light characterised by the wavelength of light used ultra-violet

Abstract

A method and apparatus is disclosed for irradiating wounds with UV radiation from which the UVB component is substantially removed or attenuated. UV light from a mercury vapor lamp (1) is passed through a filter (2) and thence through a lens (3) which focuses the radiation onto a target region (18). The filter (2) is formed from a number of alternating layers of dielectric material of different refractive indexes.

Description

The present invention relates to the phototherapy of skin wounds and, in particular, to the phototherapy of skin wounds with ultra violet light from which the UVB component (wavelengths of 280 nm to 315 nm) has been substantially removed or attenuated so that the wound is irradiated with UVC (wavelengths of 200 to 280 nm) and UVA (315 to 400 nm). Preferably the wound is also irradiated with visible and infra-red radiation.

BACKGROUND ART

Prior to the advent of modern antibiotics, it was known that beneficial effects could be obtained in the treatment of skin wounds in mammals by the irradiation of the wounds by sunlight and by carbon-arc radiation. In addition, the germicidal action of significant levels of UVC radiation is well known. Furthermore, the beneficial properties of UVA radiation have also been reported.

Such ultraviolet radiation fell into a decline with the advent of antibiotics since it suffers from the problem that the ultraviolet radiation used included excessive emissions of damaging erythemal UVB radiation which readily causes burning and blistering and is generally regarded as being carcinogenic. Since the UVB radiation was itself harmful, it was necessary to maintain the radiation level overall at a fairly low level thereby preventing the beneficial properties of the UVC and UVA components from being applied at an effective dosage level.

Whilst antibotics were initially spectacularly successful, many organisms have now developed resistance to antibotics and therefore higher doses and longer periods of treatment are required. In addition, in some applications, such as the treatment of racehorses, there are objections to the use of antibiotics and it is often difficult to apply bandages and other surface treatments to the legs of racehorses in particular.

It is therefore an object of the present invention to overcome the disadvantages inherent with antibiotic treatment and provide a method and apparatus whereby the germicidal and other beneficial properties of UV radiation can be utilized without the unnecessary, short-term damage and possible carcinogenic problems inherent with UVB radiation by the reduction or substantial elimination of the UVB component.

SUMMARY OF THE INVENTION

According to one aspect of the present invention there is disclosed a method of phototherapy of skin wounds of mammals, said method comprising the step of irradiating the wound area with ultraviolet light from which the UVB component has been substantially removed or attenuated whereby the wound is irradiated with substantially UVA and UVC radiation. Preferably the wound is also irradiated with visible light and/or infra-red radiation.

In accordance with another aspect of the present invention there is disclosed apparatus for carrying out the above method and comprising a source of UV radiation, focusing means to focus the UV radiation onto a target area, and a filter placed in said radiation to substantially remove or attenuate any UVB component in said radiation. Preferably a monitor device is provided in order to monitor the radiation dosage.

DESCRIPTION OF THE PREFERRED EMBODIMENT

A preferred embodiment of the present invention will now be described with reference to the drawings in which:

FIG. 1 is a horizontal cross-sectional view through the apparatus of the preferred embodiment,

FIG. 2 is a centrally located vertical cross-section through the apparatus of FIG. 1,

FIG. 3 is an enlarged view of the vertical section through the monitor optics illustrated in FIG. 2, and

FIG. 4 is a front elevational view of the monitor optics arrangement of FIG. 3.

As seen in the drawings, the apparatus of the preferred embodiment comprises a high-pressure mercury-vapor gas-discharge lamp 1, with a quartz envelope, preferably having a power of approximately 100 W which is mounted vertically within a lamp enclosure 16 formed from UV stable material. The enclosure 16 is provided with light baffles 13 and a cooling fan 15. At one end of the lamp enclosure 16 is a selective-UV filter 2 (to be described hereafter) which substantially prevents the passage of UVB radiation.

The UV and visible radiation which passes through the filter 2 is allowed to fall onto a plano-convex fused silica lens 3 which focuses the radiation into a beam 17 which falls upon a target region 18. Mounted in front of the lens 3 is a removeable UV-absorbing lens-cover filter 4 which, as best seen in FIG. 2, is pivoted or slidable as indicated by arrows 12 into, and out of, the beam 17. This filter is used during initial target selection and to control the UV exposure time.

Centrally positioned on the lens 3 is a prism 5 which is shielded on its surface facing the mercury discharge lamp 1 and gathers reflected light 19 from the target region. A monitor-imaging lens 6 is secured to the lower surface of the prism 5 in order to focus the reflected beam 19 through a monitor-cell aperture 8 and onto a monitor photoelectric cell 10, via a monitor-cell filter 9. As best seen in FIGS. 3 and 4, the monitor imaging-lens 6, aperture 8, filter 9, and photoelectric cell 10 are all located within a tubular light-tight monitor housing 7.

A pair of infra-red heaters 14, each with an associated reflector 20, are mounted one to either side of the light baffles 13 as illustrated in FIG. 1. The infra-red heaters 14 preferably comprise the ballast for the mercury vapor lamp 1 and can also separately be energized if only infra-red radiation 21 is desired.

The filter 2 is of special construction and comprises at least 2, and preferably upto 21 layers of dielectric material which are non-absorbing in the UV region and which have different refractive indexes. Thus if the filter 2 is regarded as a series of layers ABABAB and so on then the material A can be selected from the group consisting of hafnium dioxide (HfO2), magnesium oxide (MgO), and yittrium oxide (Y2 O3) and the material B of the alternate layers can be selected from the group consisting of aluminium oxide (Al2 O3), magnesium fluoride (MgF2) and silicon dioxide (SiO2). It will be apparent that the stack of dielectric layers constitutes an interference filter and for the materials mentioned above the filter is operable so as to reject radiation in the UVB band thereby allowing UVA and UVC to pass through the filter 2 and hence through the lens 3. Preferably the spectral transmittance for a beam normal by incidence on the filter 2 in the UVC and UVA regions is not less than 0.5 and preferably is approximately 0.8 to 0.9 whereas the spectral transmittance in the UVB region does not exceed 0.05. More layers than 21 provides an even smaller transmittance.

It will be apparent that the monitor optics enable the dosage actually received by the target area to be monitored. The choice of the monitor-cell filter 9 enables a selection to be made as to whether the UV, visible, or infra-red radiation is monitored. The monitor is focused at infinity and views directly along the main beam axis. The photo-cell aperture 8 determines the divergence of the accepted beam 19 away from the lens 3. Preferably the arrangement is such that the diameter of the beam 19 is approximately 3 cm at a distance of 50 cm from the lens 3. This gives reasonable results for a target distance of from 20 to 100 cm.

It will be apparent that by monitoring the reflected radiation, the correct dose is delivered irrespective of beam dimensions in the target plane, provided that the beam cross-section is at least as big as the monitor beam cross-section. The monitor also allows accurate dose delivery independent of the loss of radiant output of the lamp with time, which typically is approximately 50% over its useful life.

Preferably, a small disc-shaped piece (not illustrated) of retro-reflective sheeting such as that sold under the trade mark SCOTCHLITE by 3M and used for reflecting motor vehicle head lamp light, is positioned in the target plane and illuminated by the beam 17. This can be accomplished by swivelling the apparatus to locate the centre of the beam 17 on the disc-shaped piece, taking a reading and then swivelling the apparatus back again, the wound 18 and the disc-shaped piece being equidistant from the UV source 1. This measurement is used to determine the time of exposure required to give the desired dose and overcomes the problems of low wound reflectivity and variation between wounds.

The lens 3 is approximately 40-60 mm in diameter and has a focal length of approximately 50-100 mm. As illustrated in FIG. 2 the lens 3 is preferably reciprocable as indicated by arrows 11 to permit a degree of focussing, giving a beam area from approximately 25 mm2 to approximately 200 m2 at a distance from the lens of from 10 cm to 50 cm.

Preferably, an additional shutter 25 which is reciprocable in a vertical plane as indicated by arrows 26 in FIG. 2 can be added between the filter 2 and the monitor housing 7. The shutter 25 is illustrated by broken lines in FIGS. 1 and 2 and allows a background signal level from the monitor to be established in the absence of the UV radiation. This enables corrections to be made for the photo-cell darkcurrent, circuit bias, any detected ambient radiation, and the like.

The above described arrangement results in the treatment beam 17 from the mercury lamp having intensities in the following wavelength regions in the following proportions: UVC:UVB:UVA plus visible plus near infra-red being approximately equal to 1:0.05:2. The desired level for UVC radiation for a beam area of approximately 50 cm2 is an average of approximately 1 to 2 mW/cm2. The IR radiation delivered from the infra-red heaters 14 preferably has an intensity of approximately 100 mW/cm2 at a distance of approximately 30 cm and thus is approximately the same as the total irradiance from sunlight.

Experimental results to date show indications of a reduction in scarring (which is important with pedigree show animals). Also preliminary work with racehorses indicates that wounds are healed more quickly than without the radiation and, as a consequence, the racehorse suffers less loss of condition than previously.

The foregoing describes only one embodiment of the present invention and modifications, obvious to those skilled in the art, can be made thereto without departing from the scope of the present invention.

Claims (9)

I claim:
1. A method of phototherapy of skin wounds of mammals, said method comprising the step of irradiating the wound area with ultraviolet light from which the UVB component has been substantially removed or attenuated, monitoring the radiation reflected by said wound to determine the dose received by said wound,
whereby the wound is irradiated with substantially UVA and UVC radiation.
2. A method as claimed in claim 1 including the step of substantially removing or attenuating said UVB component by passing said ultraviolet light through an interference filter comprising a plurality of layers of dielectric material which are non-absorbing in the UV region, alternate ones of said layers having different refractive indexes.
3. A method as claimed in claim 2 wherein said filter comprises a stack formed from a plurality of layers of said dielectric material, the even numbered layers of said stack being a material selected from the group consisting of hafnium dioxide, magnesium oxide, and yittrium oxide, and the odd number layers of said stack being a material selected from the group consisting of aluminium oxide, magnesium fluoride and silicon dioxide.
4. A method as claimed in claim 3 including the step of simultaneously irradiating said wound with infra-red radiation and visible light.
5. A method as claimed in claim 4 including the step of simultaneously irradiating said wound with infra-red radiation and visible light.
6. Apparatus for phototherapy of skin wounds of mammals, said apparatus comprising a source of UV radiation having UVA, UVB and UVC components, focusing means to focus the UV radiation onto a target area on a skin wound of a mammal, and a filter placed in said radiation to substantially remove or attenuate only said UVB component in said radiation and to pass substantially unattenuated said UVA and UVC components and wherein a prism is located in the path of said radiation focused on said target area, the side of said prism adjacent said source of UV radiation is rendered opaque, whereby radiation reflected from the target area is incident on said prism and directed thereby through a lens to focus said reflected radiation onto a light sensitive device which is shielded from direct radiation from said UV source.
7. Apparatus as claimed in claim 6 wherein said filter means is an interference filter through which said UV radiation passes and which comprises a plurality of layers of dielectric material which are non-absorbing in the UV region, alternate ones of said layers having different refractive indexes.
8. Apparatus as claimed in claim 6 wherein said filter means comprises a stack formed from a plurality of layers of said dielectric material, the odd numbered layers of said stack being a material selected from the group consisting of hafnium dioxide, magnesium oxide, and yittrium oxide; and the even numbered layers of said stack being a material selected from the group consisting of aluminium oxide, magnesium fluoride and silicon dioxide.
9. Apparatus as claimed in claim 6 wherein a first shutter is moveable into and out of the path of said radiation to shield said target from said radiation and a second shutter is moveable into and out of the path of said radiation at a location between said prism and said UV source to shield said prism and target from radiation from said UV source whereby substantially only background radiation from said target area or wound is received by said light sensitive device.
US07086077 1985-10-09 1986-10-09 Phototherapy of skin wounds Expired - Fee Related US4909254A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AUPH282885 1985-10-09
AUPH2828 1985-10-09

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US4909254A true US4909254A (en) 1990-03-20

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US (1) US4909254A (en)
EP (1) EP0241488A4 (en)
JP (1) JPS63501622A (en)
WO (1) WO1987002256A1 (en)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5259380A (en) * 1987-11-04 1993-11-09 Amcor Electronics, Ltd. Light therapy system
US5344433A (en) * 1991-11-28 1994-09-06 Dimotech Ltd. Apparatus for the treatment of skin wounds
US5493442A (en) * 1993-04-02 1996-02-20 Balzers Aktiengellschaft Method for realizing a filter edge, optical thin-film and optical device with such a film
EP0773041A2 (en) * 1995-11-08 1997-05-14 Herbert Waldmann GmbH & Co. Photodynamic illumination device
US5871522A (en) * 1996-10-28 1999-02-16 Senasco, Inc. Apparatus and method for projecting germicidal ultraviolet radiation
US6379376B1 (en) 1996-11-25 2002-04-30 Rachel Lubart Device for light irradiation onto tissue
US6413268B1 (en) 2000-08-11 2002-07-02 Raymond A. Hartman Apparatus and method for targeted UV phototherapy of skin disorders
US6447537B1 (en) 2000-06-21 2002-09-10 Raymond A. Hartman Targeted UV phototherapy apparatus and method
US20020146343A1 (en) * 2000-12-14 2002-10-10 Jenkins Geoffrey H. Method and apparatus for rapidly sterilizing small objects
US20020168287A1 (en) * 2001-03-27 2002-11-14 Richard Eckhardt Method and apparatus for rapidly sterilizing irregularly-shaped objects
US20040034398A1 (en) * 2001-06-15 2004-02-19 Uv-Solutions, Llc Method and apparatus for sterilizing or disinfecting a region through a bandage
EP1487367A2 (en) * 2001-12-06 2004-12-22 Curelight Ltd Phototherapy for psoriasis and other skin disorders
US20060004425A1 (en) * 2002-02-11 2006-01-05 Cumbie William E Prevention and treatment of skin and nail infections using germicidal light
US20060173515A1 (en) * 2002-02-11 2006-08-03 Cumbie William E Alteration of the skin and nail for the prevention and treatment of skin and nail infections
US20060195165A1 (en) * 2005-01-25 2006-08-31 Michael Gertner Optical therapy devices, systems, kits and methods for providing therapy to a body cavity
US20070208395A1 (en) * 2005-10-05 2007-09-06 Leclerc Norbert H Phototherapy Device and Method of Providing Phototherapy to a Body Surface
US20070219600A1 (en) * 2006-03-17 2007-09-20 Michael Gertner Devices and methods for targeted nasal phototherapy
EP1839704A1 (en) * 2006-03-30 2007-10-03 Espansione Marketing S.P.A. Device for performing aesthetic treatments
US20080208295A1 (en) * 2007-02-28 2008-08-28 Cumbie William E Phototherapy Treatment and Device to Improve the Appearance of Nails and skin
US20100241196A1 (en) * 2009-03-19 2010-09-23 Tyco Healthcare Group Lp Phototherapy wound treatment
US20120076375A1 (en) * 2010-09-21 2012-03-29 Sony Corporation Detecting device, detecting method, program, and electronic apparatus
WO2012122210A1 (en) 2011-03-07 2012-09-13 The Trustees Of Columbia University In The City Of New York Apparatus, method, and system for selectively affecting and/or killing bacteria
EP2500060A1 (en) * 2011-03-17 2012-09-19 JK-Holding GmbH Device for irradiating actinic radiation of different wavelengths

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GB8719637D0 (en) * 1987-08-20 1987-09-30 Thompson W H Life frequency radiant energy treatment
DE3803763A1 (en) * 1988-02-08 1989-08-17 Vught Barbara Van Optical irradition device for biological matter
DE8915927U1 (en) * 1989-03-21 1992-04-16 Mutzhas, Maximilian Friedrich, Prof. Dr.-Ing., 8000 Muenchen, De

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Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5259380A (en) * 1987-11-04 1993-11-09 Amcor Electronics, Ltd. Light therapy system
US5344433A (en) * 1991-11-28 1994-09-06 Dimotech Ltd. Apparatus for the treatment of skin wounds
US5493442A (en) * 1993-04-02 1996-02-20 Balzers Aktiengellschaft Method for realizing a filter edge, optical thin-film and optical device with such a film
EP0773041A2 (en) * 1995-11-08 1997-05-14 Herbert Waldmann GmbH & Co. Photodynamic illumination device
EP0773041A3 (en) * 1995-11-08 1999-03-10 Herbert Waldmann GmbH & Co. Photodynamic illumination device
US5871522A (en) * 1996-10-28 1999-02-16 Senasco, Inc. Apparatus and method for projecting germicidal ultraviolet radiation
US6379376B1 (en) 1996-11-25 2002-04-30 Rachel Lubart Device for light irradiation onto tissue
US6447537B1 (en) 2000-06-21 2002-09-10 Raymond A. Hartman Targeted UV phototherapy apparatus and method
US6413268B1 (en) 2000-08-11 2002-07-02 Raymond A. Hartman Apparatus and method for targeted UV phototherapy of skin disorders
US20020146343A1 (en) * 2000-12-14 2002-10-10 Jenkins Geoffrey H. Method and apparatus for rapidly sterilizing small objects
US20050254992A1 (en) * 2000-12-14 2005-11-17 Uv-Solutions, Llc Methods and apparatus for indicating sterilization or disinfection of objects
US20050236579A1 (en) * 2000-12-14 2005-10-27 Uv-Solutions, Llc Methods for rapidly sterilizing a small object
US20020168287A1 (en) * 2001-03-27 2002-11-14 Richard Eckhardt Method and apparatus for rapidly sterilizing irregularly-shaped objects
US20040034398A1 (en) * 2001-06-15 2004-02-19 Uv-Solutions, Llc Method and apparatus for sterilizing or disinfecting a region through a bandage
US6730113B2 (en) * 2001-06-15 2004-05-04 Uv-Solutions Llc Method and apparatus for sterilizing or disinfecting a region through a bandage
EP1487367A2 (en) * 2001-12-06 2004-12-22 Curelight Ltd Phototherapy for psoriasis and other skin disorders
US20050143793A1 (en) * 2001-12-06 2005-06-30 Avner Korman Phototherapy for psoriasis and other skin disordes
US7306620B2 (en) 2002-02-11 2007-12-11 Keraderm, Llc Prevention and treatment of skin and nail infections using germicidal light
US20060173515A1 (en) * 2002-02-11 2006-08-03 Cumbie William E Alteration of the skin and nail for the prevention and treatment of skin and nail infections
US20070255266A1 (en) * 2002-02-11 2007-11-01 Cumbie William E Method and device to inactivate and kill cells and organisms that are undesirable
US20060004425A1 (en) * 2002-02-11 2006-01-05 Cumbie William E Prevention and treatment of skin and nail infections using germicidal light
US7494502B2 (en) 2002-02-11 2009-02-24 Keraderm, Llc Alteration of the skin and nail for the prevention and treatment of skin and nail infections
US8109981B2 (en) 2005-01-25 2012-02-07 Valam Corporation Optical therapies and devices
US20060195165A1 (en) * 2005-01-25 2006-08-31 Michael Gertner Optical therapy devices, systems, kits and methods for providing therapy to a body cavity
US20080208297A1 (en) * 2005-01-25 2008-08-28 Allux Medical, Inc. Optical Therapy Devices, Systems, Kits and Methods for Providing Therapy to a body Cavity
US20070208395A1 (en) * 2005-10-05 2007-09-06 Leclerc Norbert H Phototherapy Device and Method of Providing Phototherapy to a Body Surface
US20070219600A1 (en) * 2006-03-17 2007-09-20 Michael Gertner Devices and methods for targeted nasal phototherapy
EP1839704A1 (en) * 2006-03-30 2007-10-03 Espansione Marketing S.P.A. Device for performing aesthetic treatments
US20080208295A1 (en) * 2007-02-28 2008-08-28 Cumbie William E Phototherapy Treatment and Device to Improve the Appearance of Nails and skin
US20100241196A1 (en) * 2009-03-19 2010-09-23 Tyco Healthcare Group Lp Phototherapy wound treatment
US8399731B2 (en) 2009-03-19 2013-03-19 Covidien Lp Phototherapy wound treatment
US20120076375A1 (en) * 2010-09-21 2012-03-29 Sony Corporation Detecting device, detecting method, program, and electronic apparatus
US8411920B2 (en) * 2010-09-21 2013-04-02 Sony Corporation Detecting device, detecting method, program, and electronic apparatus
WO2012122210A1 (en) 2011-03-07 2012-09-13 The Trustees Of Columbia University In The City Of New York Apparatus, method, and system for selectively affecting and/or killing bacteria
US20160107000A1 (en) * 2011-03-07 2016-04-21 The Trustees Of Columbia University In The City Of New York Apparatus, method, and system for selectively effecting and/or killing bacteria
EP2683442A1 (en) * 2011-03-07 2014-01-15 The Trustees of Columbia University in the City of New York Apparatus, method, and system for selectively affecting and/or killing bacteria
EP2683442A4 (en) * 2011-03-07 2014-08-20 Univ Columbia Apparatus, method, and system for selectively affecting and/or killing bacteria
US10071262B2 (en) 2011-03-07 2018-09-11 The Trustees Of Columbia University In The City Of New York Apparatus, method, and system for selectively effecting and/or killing bacteria
US9278232B2 (en) 2011-03-17 2016-03-08 Jk-Holding Gmbh Device for irradiating actinic radiation of different wavelengths
EP2500060A1 (en) * 2011-03-17 2012-09-19 JK-Holding GmbH Device for irradiating actinic radiation of different wavelengths

Also Published As

Publication number Publication date Type
WO1987002256A1 (en) 1987-04-23 application
EP0241488A4 (en) 1988-03-18 application
JPS63501622A (en) 1988-06-23 application
EP0241488A1 (en) 1987-10-21 application

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