US4770860A - Porous hydroxyl apatite material - Google Patents
Porous hydroxyl apatite material Download PDFInfo
- Publication number
- US4770860A US4770860A US07/095,066 US9506687A US4770860A US 4770860 A US4770860 A US 4770860A US 9506687 A US9506687 A US 9506687A US 4770860 A US4770860 A US 4770860A
- Authority
- US
- United States
- Prior art keywords
- hydroxyl apatite
- porous
- artificial
- porous hydroxyl
- bone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000463 material Substances 0.000 title claims abstract description 45
- 229910052588 hydroxylapatite Inorganic materials 0.000 title claims abstract description 28
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title claims abstract description 28
- 241000195493 Cryptophyta Species 0.000 claims abstract description 10
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 8
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000011575 calcium Substances 0.000 claims abstract description 4
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 4
- 230000003416 augmentation Effects 0.000 claims abstract 2
- 230000006641 stabilisation Effects 0.000 claims abstract 2
- 238000011105 stabilization Methods 0.000 claims abstract 2
- 239000011148 porous material Substances 0.000 claims description 7
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 230000007547 defect Effects 0.000 abstract 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 4
- 239000008187 granular material Substances 0.000 description 3
- 238000010335 hydrothermal treatment Methods 0.000 description 3
- 238000002803 maceration Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 235000014653 Carica parviflora Nutrition 0.000 description 2
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 235000011941 Tilia x europaea Nutrition 0.000 description 2
- 238000005054 agglomeration Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- LGECYHKACRVEKY-UHFFFAOYSA-L copper;azane;dihydroxide Chemical compound N.N.N.N.[OH-].[OH-].[Cu+2] LGECYHKACRVEKY-UHFFFAOYSA-L 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000004571 lime Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
- 238000000197 pyrolysis Methods 0.000 description 2
- 238000005245 sintering Methods 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 241000242757 Anthozoa Species 0.000 description 1
- 241000258957 Asteroidea Species 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 241000243321 Cnidaria Species 0.000 description 1
- 241000196226 Codiaceae Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 241001491621 Corallina officinalis Species 0.000 description 1
- 241001428391 Corallinaceae Species 0.000 description 1
- 241000178557 Corallium Species 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 241000248841 Halimeda Species 0.000 description 1
- 241000233494 Lithophyllum Species 0.000 description 1
- 241000230999 Lithothamnion Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 229910000318 alkali metal phosphate Inorganic materials 0.000 description 1
- LFVGISIMTYGQHF-UHFFFAOYSA-N ammonium dihydrogen phosphate Chemical compound [NH4+].OP(O)([O-])=O LFVGISIMTYGQHF-UHFFFAOYSA-N 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 125000005587 carbonate group Chemical group 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000009770 conventional sintering Methods 0.000 description 1
- -1 copper complex salts Chemical class 0.000 description 1
- 229940079920 digestives acid preparations Drugs 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 239000010440 gypsum Substances 0.000 description 1
- 229910052602 gypsum Inorganic materials 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000001027 hydrothermal synthesis Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- AMXOYNBUYSYVKV-UHFFFAOYSA-M lithium bromide Inorganic materials [Li+].[Br-] AMXOYNBUYSYVKV-UHFFFAOYSA-M 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 description 1
- 239000000622 polydioxanone Substances 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/70—Preparations for dentistry comprising inorganic additives
- A61K6/71—Fillers
- A61K6/74—Fillers comprising phosphorus-containing compounds
- A61K6/75—Apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/858—Calcium sulfates, e.g, gypsum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
Definitions
- the present invention relates to a porous hydroxyl apatite material and to the employment thereof in medicine, dentistry and veterinary medicine.
- porous hydroxyl apatite material which is characterized in that the material is produced from the calcium-rich basic skeletons of lime-encrusting algae converted into the hydroxyl apatite material.
- the pores of the porous hydroxyl apatite material are filled with a re-absorbable or a bone-inducing material such as bone marrow.
- porous hydroxyl apatite material according to the invention is useful, in particular, as artificial bone, artificial tooth root, stabilizing material, artificial hollow bodies, supplementary material, lining material or defect-filling material.
- all algae and in particular those from the littorals and sub-littorals of the oceans, in particular species of Corallinaceae such as Corallina officinalis, Corallium, rubens, Lithothamion calcarum and species of Codiaceae, e.g. Halimeda spec., including benthish crust-forming algae such as Lithothamnion spec. and Lithophyllum spec. can be used, which, in general, encrust lime, even if only to a small extent.
- Corallinaceae such as Corallina officinalis, Corallium, rubens, Lithothamion calcarum
- species of Codiaceae e.g. Halimeda spec., including benthish crust-forming algae such as Lithothamnion spec. and Lithophyllum spec.
- benthish crust-forming algae such as Lithothamnion spec. and Lithophyllum spec.
- the organic components of the algae must firstly be removed.
- This can be effected by so-called "maceration”.
- vital or dried algae material can be treated with copper complex salts, e.g. Schweizer's reagent or with lithium chloride or bromide solutions, or subjected to pyrolysis.
- Such maceration processes i.e. methods of treatment for removing the organic material, are likewise described in the aforesaid U.S. Pat. No. 3,929,971, e.g. submersion in dilute sodium hypochlorite solutions.
- the remaining calcium carbonate basic material freed of organic substance and existing in granular form, is thoroughly washed with distilled water.
- the grain size of the material is between 0.1 and 2 millimeters.
- the calcium-rich basic skeleton obtained from the algae is then converted into hydroxyl apatite in a known manner.
- This conversion into hydroxyl apatite is usually effected by a hydrothermal process or by the use of a phosphate salt bath.
- alkali metal phosphates such as sodium orthophosphate, potassium orthophosphate and ammonium orthophosphate, acidic phosphates and phosphate mixtures may be employed.
- orthophosphoric acids may also be employed for this purpose.
- This hydrothermal treatment for converting calcium carbonate into hydroxyl apatite is likewise disclosed in the aforesaid U.S. Pat. No. 3,929,971. The hydrothermal treatment is carried out in the usual way at high pressure and at high temperature.
- An example for such a treatment comprises maintaining the porous, macerated granules of lime-encrusting algae with sodium hydrogen phosphate and doubly-distilled water in proportions of 1:1:4 in a closed container for two to three days under the following conditions:
- the hydroxyl apatite material After the hydrothermal treatment, the hydroxyl apatite material usually exhibits a granular form. From this granular form, compact pieces can be produced by agglomeration, e.g. by conventional sintering methods, if required under the application of pressure and with the addition of conventional sinter-promoting materials.
- the granular material is firstly pressed into molded bodies and after a pre-heating phase of approximately 4 hours, these are then roasted at a temperature of 1000° to 1400° C. for 4 to 5 hours, and subsequently cooled, e.g. over 4 to 5 hours.
- the sintering is carried out with the addition of an empirically determined amount of H 2 O (double-distilled).
- the pores of the hydroxyl apatite material according to the invention may be filled with re-absorbable materials.
- re-absorbable materials lyophilisized heterologous collagen filaments, homologous lyophilized fibrin, gypsum, proteins such as marrow or polylactic acid preparations, e.g. polydioxanones, may be employed.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Zoology (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Materials For Medical Uses (AREA)
- Dental Preparations (AREA)
- Heat Treatment Of Steel (AREA)
- Heat Treatment Of Sheet Steel (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cultivation Of Seaweed (AREA)
- Artificial Fish Reefs (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3542744A DE3542744C1 (de) | 1985-12-03 | 1985-12-03 | Poroeses Hydroxylapatit-Material |
| DE3542744 | 1985-12-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US4770860A true US4770860A (en) | 1988-09-13 |
Family
ID=6287503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US07/095,066 Expired - Lifetime US4770860A (en) | 1985-12-03 | 1986-12-03 | Porous hydroxyl apatite material |
Country Status (9)
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5618549A (en) * | 1993-05-13 | 1997-04-08 | Inoteb | Use of particles of a biocompatible and bioabsorbable calcium salt as active ingredient in the preparation of a medicinal product intended for the local treatment of bone demineralization diseases |
| US5668203A (en) * | 1995-06-07 | 1997-09-16 | Xerox Corporation | Elastomeric articles containing haloceramer compositions |
| US6033730A (en) * | 1997-10-15 | 2000-03-07 | Coral Biotech Kabushiki Kaisha | Weathered reef-building coral material |
| RU2168998C1 (ru) * | 2000-02-14 | 2001-06-20 | Волова Лариса Теодоровна | Способ получения аллогенного гидроксилапатита |
| US20040019132A1 (en) * | 2001-02-23 | 2004-01-29 | Marc Long | Bone graft substitutes |
| US20040062816A1 (en) * | 2002-07-31 | 2004-04-01 | Atkinson Brent L. | Bone repair putty |
| US20060121084A1 (en) * | 2004-12-08 | 2006-06-08 | Borden Mark D | Continuous phase composite for musculoskeletal repair |
| US20070141110A1 (en) * | 2004-12-09 | 2007-06-21 | Biomet Sports Medicine, Inc. | Continuous phase compositions for ACL repair |
| US20090138096A1 (en) * | 2004-12-08 | 2009-05-28 | Myerson Mark S | Foot/ankle implant and associated method |
| EP1464306B2 (de) † | 1993-09-21 | 2014-06-11 | Synthes GmbH | Implantat für den Zwischenwirbelraum |
| US8876532B2 (en) | 2002-07-31 | 2014-11-04 | Dentsply International Inc. | Bone repair putty |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3709897A1 (de) * | 1987-03-26 | 1988-10-06 | Ewers Rolf | Verfahren zur herstellung eines hydroxylapatitmaterials |
| EP0355136B1 (de) * | 1987-12-23 | 1994-07-13 | BEGO Bremer Goldschlägerei Wilh. Herbst GmbH & Co. | Zahnfüllungsmaterial |
| FR2637502A1 (fr) * | 1988-10-12 | 1990-04-13 | Duroselle Patrick | Materiau de xenogreffe osseuse et procede d'obtention |
| US4976736A (en) * | 1989-04-28 | 1990-12-11 | Interpore International | Coated biomaterials and methods for making same |
| FR2647334A1 (fr) * | 1989-05-23 | 1990-11-30 | Cazprasse Serge | Produits de remplacement de structures osseuses et radiculo-dentaires en nacre |
| FR2706768B1 (enrdf_load_stackoverflow) * | 1993-05-13 | 1995-12-01 | Inoteb | |
| DE19543110C2 (de) * | 1995-11-18 | 1998-05-28 | Guy Florian Draenert | Steriles Knochenmaterial nativen Ursprungs für die Transplantation und Verfahren zur Hitzesterilisierung des Knochenmaterials |
| BG101544A (en) * | 1997-05-30 | 1998-11-30 | Медицински Университет-Ректорат | Method for the preparation of biologically active coatings over titanium osteal implants |
| DE19723287A1 (de) * | 1997-06-04 | 1998-12-10 | Castolin Sa | Implantat zum Einsatz bei Lebewesen, Verfahren zur Herstellung des Implantats sowie dessen Verwendung |
| DE19950113A1 (de) * | 1999-10-18 | 2001-05-03 | Jordanova Spassova Margarita | Tricalciumphosphat-haltiges Hydroxylapatit-Material |
| DE19950114A1 (de) * | 1999-10-18 | 2001-04-26 | Jordanova Spassova Margarita | Knochenersatzmaterial und Vorstufen hierfür |
| US6881227B2 (en) | 1999-11-30 | 2005-04-19 | Margarita Jordanova-Spassova | Hydroxylapatite material containing tricalcium phosphate with microporous structure |
| DE102005060761B4 (de) * | 2005-12-16 | 2007-10-25 | Alexakis, Antonis, Dr. med. dent. | Formteil zur Neubildung von Knochenmaterial |
| JP5053624B2 (ja) * | 2006-11-18 | 2012-10-17 | 学校法人東京歯科大学 | 歯質強化剤及びその製造方法 |
| DE102007050440A1 (de) * | 2007-10-18 | 2009-04-23 | Alexakis, Antonis, Dr. med. dent. | Beschichtetes Granulat zur Neubildung von Knochenmaterial |
| CN101954122A (zh) * | 2010-09-13 | 2011-01-26 | 陕西瑞盛生物科技有限公司 | 具有预塑性天然骨修复材料的制备方法 |
| DE102011119909A1 (de) * | 2011-12-01 | 2013-06-06 | Antonis Alexakis | Regenerations Hilfe für Knochendefekte |
| ES2922210T3 (es) | 2019-08-16 | 2022-09-09 | Univ Heidelberg | Sustitución osteotrópica de hueso |
| EP4574180A1 (de) | 2023-12-19 | 2025-06-25 | Andreas Haas | Modifiziertes knochenersatzmaterial |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2043238A (en) * | 1934-07-02 | 1936-06-09 | Tennessee Valley Authority | Manufacture of di-calcium phosphate |
| US2053266A (en) * | 1934-05-21 | 1936-09-08 | Tennessee Valley Authority | Manufacture of calcium phosphates |
| US2067538A (en) * | 1934-01-05 | 1937-01-12 | Walter H Macintire | Process for making double or treble (calcium) superphosphate |
| US2143025A (en) * | 1936-03-02 | 1939-01-10 | Roger H Newton | Making monocalcium phosphate |
| US3236593A (en) * | 1960-01-16 | 1966-02-22 | Knapsack Ag | Process for the manufacture of a mineral feed additive essentially consisting of dicalcium phosphate |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3929971A (en) * | 1973-03-30 | 1975-12-30 | Research Corp | Porous biomaterials and method of making same |
| NL7704659A (nl) * | 1976-05-12 | 1977-11-15 | Battelle Institut E V | Beendervervangings-, beenderverbindings- of prothesenverankeringsmateriaal. |
| CH643732A5 (en) * | 1978-01-01 | 1984-06-29 | Scheicher Hans | Aid for covering and/or filling bone defects and process for the production thereof |
| FR2460710A1 (fr) * | 1979-04-02 | 1981-01-30 | Basset Francois | Produit absorbant industriel contenant un produit vegetal |
| FR2460657A1 (fr) * | 1979-07-12 | 1981-01-30 | Anvar | Implant biodegradable utilisable comme piece de prothese osseuse |
-
1985
- 1985-12-03 DE DE3542744A patent/DE3542744C1/de not_active Expired
-
1986
- 1986-12-03 WO PCT/EP1986/000702 patent/WO1987003491A1/de unknown
- 1986-12-03 AU AU67356/87A patent/AU583443B2/en not_active Expired
- 1986-12-03 DE DE8686116817T patent/DE3669829D1/de not_active Expired - Lifetime
- 1986-12-03 US US07/095,066 patent/US4770860A/en not_active Expired - Lifetime
- 1986-12-03 CA CA000524437A patent/CA1276430C/en not_active Expired - Lifetime
- 1986-12-03 ES ES86116817T patent/ES2014976B3/es not_active Expired - Lifetime
- 1986-12-03 JP JP62500225A patent/JPS63500778A/ja active Granted
- 1986-12-03 AT AT86116817T patent/ATE51346T1/de not_active IP Right Cessation
- 1986-12-03 EP EP86116817A patent/EP0230570B1/de not_active Expired - Lifetime
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2067538A (en) * | 1934-01-05 | 1937-01-12 | Walter H Macintire | Process for making double or treble (calcium) superphosphate |
| US2053266A (en) * | 1934-05-21 | 1936-09-08 | Tennessee Valley Authority | Manufacture of calcium phosphates |
| US2043238A (en) * | 1934-07-02 | 1936-06-09 | Tennessee Valley Authority | Manufacture of di-calcium phosphate |
| US2143025A (en) * | 1936-03-02 | 1939-01-10 | Roger H Newton | Making monocalcium phosphate |
| US3236593A (en) * | 1960-01-16 | 1966-02-22 | Knapsack Ag | Process for the manufacture of a mineral feed additive essentially consisting of dicalcium phosphate |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5618549A (en) * | 1993-05-13 | 1997-04-08 | Inoteb | Use of particles of a biocompatible and bioabsorbable calcium salt as active ingredient in the preparation of a medicinal product intended for the local treatment of bone demineralization diseases |
| EP1464306B2 (de) † | 1993-09-21 | 2014-06-11 | Synthes GmbH | Implantat für den Zwischenwirbelraum |
| US5668203A (en) * | 1995-06-07 | 1997-09-16 | Xerox Corporation | Elastomeric articles containing haloceramer compositions |
| US6033730A (en) * | 1997-10-15 | 2000-03-07 | Coral Biotech Kabushiki Kaisha | Weathered reef-building coral material |
| RU2168998C1 (ru) * | 2000-02-14 | 2001-06-20 | Волова Лариса Теодоровна | Способ получения аллогенного гидроксилапатита |
| US20040019132A1 (en) * | 2001-02-23 | 2004-01-29 | Marc Long | Bone graft substitutes |
| EP2295089A2 (en) | 2002-07-31 | 2011-03-16 | DENTSPLY International Inc. | Bone repair putty comprising porous particulate and carrier gel |
| US7842300B2 (en) * | 2002-07-31 | 2010-11-30 | Dentsply International, Inc. | Bone repair putty |
| US20040062816A1 (en) * | 2002-07-31 | 2004-04-01 | Atkinson Brent L. | Bone repair putty |
| US8876532B2 (en) | 2002-07-31 | 2014-11-04 | Dentsply International Inc. | Bone repair putty |
| WO2006062518A3 (en) * | 2004-12-08 | 2006-08-03 | Interpore Spine Ltd | Continuous phase composite for musculoskeletal repair |
| US20090138096A1 (en) * | 2004-12-08 | 2009-05-28 | Myerson Mark S | Foot/ankle implant and associated method |
| US7879109B2 (en) | 2004-12-08 | 2011-02-01 | Biomet Manufacturing Corp. | Continuous phase composite for musculoskeletal repair |
| US20060121084A1 (en) * | 2004-12-08 | 2006-06-08 | Borden Mark D | Continuous phase composite for musculoskeletal repair |
| US8679191B2 (en) | 2004-12-08 | 2014-03-25 | Biomet Manufacturing, Llc | Continuous phase composite for musculoskeletal repair |
| US9456905B2 (en) | 2004-12-08 | 2016-10-04 | Biomet Manufacturing, Llc | Continuous phase composite for musculoskeletal repair |
| US20070141110A1 (en) * | 2004-12-09 | 2007-06-21 | Biomet Sports Medicine, Inc. | Continuous phase compositions for ACL repair |
| US8535357B2 (en) | 2004-12-09 | 2013-09-17 | Biomet Sports Medicine, Llc | Continuous phase compositions for ACL repair |
| US9211184B2 (en) | 2004-12-09 | 2015-12-15 | Biomet Sports Medicine, Llc | Continuous phase compositions for ACL repair |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2014976B3 (es) | 1990-08-01 |
| CA1276430C (en) | 1990-11-20 |
| WO1987003491A1 (en) | 1987-06-18 |
| JPH0346146B2 (enrdf_load_stackoverflow) | 1991-07-15 |
| ATE51346T1 (de) | 1990-04-15 |
| EP0230570B1 (de) | 1990-03-28 |
| DE3669829D1 (de) | 1990-05-03 |
| EP0230570A1 (de) | 1987-08-05 |
| DE3542744C1 (de) | 1987-05-27 |
| AU6735687A (en) | 1987-06-30 |
| JPS63500778A (ja) | 1988-03-24 |
| AU583443B2 (en) | 1989-04-27 |
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