US4630873A - Apparatus for low temperature storage of biological or pharmaceutical samples - Google Patents

Apparatus for low temperature storage of biological or pharmaceutical samples Download PDF

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Publication number
US4630873A
US4630873A US06/664,318 US66431884A US4630873A US 4630873 A US4630873 A US 4630873A US 66431884 A US66431884 A US 66431884A US 4630873 A US4630873 A US 4630873A
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US
United States
Prior art keywords
ampoules
pins
box
side walls
boxes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
US06/664,318
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English (en)
Inventor
Wolfgang Volker
Klemens Thoma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Messer Griesheim GmbH
Original Assignee
Messer Griesheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Messer Griesheim GmbH filed Critical Messer Griesheim GmbH
Assigned to MESSER GRIESHEIM GMBH, A COMPANY OF GERMANY reassignment MESSER GRIESHEIM GMBH, A COMPANY OF GERMANY ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: THOMA, KLEMENS, VOLKER, WOLFGANG
Application granted granted Critical
Publication of US4630873A publication Critical patent/US4630873A/en
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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/06—Test-tube stands; Test-tube holders
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
    • F25D25/00—Charging, supporting, and discharging the articles to be cooled
    • F25D25/005—Charging, supporting, and discharging the articles to be cooled using containers

Definitions

  • the invention relates to an apparatus for low temperature storage of biological or pharmaceutical samples.
  • ampullas are spatially separated by rods or walls of the grid-like holders so that the space requirement of each ampulla is increased.
  • the invention is based on the object of finding a compact and easy to hand type of ampulla storage. This object is met by a section-like apparatus wherein the ampullas are placed in boxes by a section-like apparatus wherein the ampullas are placed in boxes separated by pins in each box.
  • each box normally have the same length.
  • the place of each ampulla with respect to the pin, and, therefore, inside the box can be exactly established by a defined unequal pin length.
  • a box consisting, for example, of ND-PE can be sealed so that one of the pins fastened to the bottom plate has a longitudinal bore and an additional pin is fastened on the inside of the cover plate and positioned over this pin which passes through the longitudinal bore through the bottom plate which in this location is also drilled through so that this pin can be welded to the bottom plate with the result that the upper and lower part of the box cannot be separated from each other without difficulty.
  • each of the tower-like cases which can be inserted in the container completely open on at least two of their opposing sides so that the length of each of the boxes to be stored on the partitions of the cases can have exactly the same length as the distance of the opposing open sides of each case.
  • each partition has at least one projection which can be engaged in a recess arranged in the partition and/or bottom plate of the upper, respectively, lower part of a box.
  • This engagement can be especially advantageously arranged in a groove-like recess extending in the inside of the box positioned near the pins.
  • FIG. 1 is a systematic plan view of the inside space of a container containing 24 cases
  • FIG. 2 shows a perspective view of the case of FIG. 1;
  • FIG. 3 shows a partial view of a case in perspective according to FIG. 2 with a partly inserted box
  • FIG. 4 shows a systematic plan view of the inside space of the box according to FIG. 3;
  • FIG. 5 shows a cross section along line L in FIG. 3.
  • FIG. 1 the inside wall of a container for storing, in this case, 24 tower-like cases is indicated with 8. These cases are stored at low temperature in the container selectively in the gas or liquid phase of nitrogen.
  • Each of the cases 10 has a number on the top: 1, 2, 3 . . . 24 for their identification.
  • a carrying handle is provided on the top of the cases 10 to easily lift the cases from the container.
  • the case 10 has a rectangular plan and is completely open on two opposing sides.
  • partitions 14 above one another are arranged and are provided with projections 26. Boxes 18 can be engaged in these projections.
  • the projections 26 are equally far removed from the edge of the partition 15.
  • the box consists of an upper part 22 and a lower part 20 (FIG. 3).
  • a groove-like recess 32 has been stamped which extends over almost the entire length of the box.
  • the box is guided by this recess 32 of the projection 26 during insertion on the partition 14 in the case 10.
  • the projections 26 are provided at a distance from each other on the partition 14 which corresponds to the maximum outside dimension of a case.
  • the case 10 shown in FIG. 2, resp. 3 is, therefore, designed each time for three boxes 18 arranged next to each other. Any number of boxes may, of course, be accommodated next to each other on the partitions 14 of each case 10.
  • the height distance of the partitions 14 from each other corresponds to the maximum height of the box 18 in closed condition.
  • the box maintains a light contact pressure with the two partitions 14 defining the box below and above during insertion into the case and during storage. Cases which are stored in the liquid phase of the medium cooling the container 8 can, therefore, not float up.
  • pins 40, 42 are arranged inside the lower part 20 of the box 18. These pins are removed equally far from the side walls 24 of the lower part 20. The center distance of these pins from these side walls 24 as well as from each other is the same as the outside diameter of the ampoules or ampullas 16 to be stored in the box 18.
  • Several rows of pins can, of course, also be arranged parallel to each other in one box.
  • the ampullas are unambigously fixed in their intended position so that sliding or tipping over of the ampullas in the box is prevented.
  • the pins 40 generally have the same height, but the pins may also have different lengths. As a result of this type of defined unequal pin length, the exact position of a certain pin in the box, and, therefore, also the exact position of each ampulla in this box can be determined.
  • a pin 46 fastened to the upper part 22 projects through a longitudinal bore 44 of a pin 42 fastened in the lower part 20 into the groove-like recess of the bottom plate 28 so that the pin 46 can be fastened to the bottom plate 28 on the bottom.
  • a box made of ND-PE is suitable in this case of low temperature storage.
  • a box produced from this material can now be easily sealed by welding this pin 46 on the bottom to the bottom plate 28. As a result, the box 18 can only be opened by destroying the seal or by separating the pin 46 from the upper part 22.
  • the groove-like recess 32 (FIG. 5) has cross walls at two locations 34, 36 so that a recess 30 is produced in between in which a projection 26 of the partition 14 can engage.
  • One of the cross walls runs in a flat incline 38 in longitudinal direction of the box 18 into the recess 32 in contrast with the wall in location 36 so that the box 18 can only be inserted with one side over the projection 26 in the partition 14. This improves the possibility of positional definition of the ampullas in the box and consequently, ultimately, in the container 8 since the box 18 can also be characterized with respect to its "front" and "back".

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Combustion & Propulsion (AREA)
  • Physics & Mathematics (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Packaging Frangible Articles (AREA)
  • Devices For Use In Laboratory Experiments (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Packages (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Sampling And Sample Adjustment (AREA)
US06/664,318 1983-11-24 1984-10-24 Apparatus for low temperature storage of biological or pharmaceutical samples Expired - Fee Related US4630873A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3342489 1983-11-24
DE3342489A DE3342489C2 (de) 1983-11-24 1983-11-24 Vorrichtung zur tiefkalten Lagerung von biologischen oder pharmazeutischen Proben

Publications (1)

Publication Number Publication Date
US4630873A true US4630873A (en) 1986-12-23

Family

ID=6215149

Family Applications (1)

Application Number Title Priority Date Filing Date
US06/664,318 Expired - Fee Related US4630873A (en) 1983-11-24 1984-10-24 Apparatus for low temperature storage of biological or pharmaceutical samples

Country Status (6)

Country Link
US (1) US4630873A (de)
EP (1) EP0143306B1 (de)
AT (1) ATE38892T1 (de)
DE (1) DE3342489C2 (de)
ES (1) ES291667Y (de)
ZA (1) ZA849131B (de)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525512A (en) * 1992-08-18 1996-06-11 Robocon Labor Und Industrieroboterges M.B.H. Incubator
EP1012499A4 (de) * 1996-01-30 2000-07-05 Organogenesis Inc Vorrichtung zur eiskristallbildung fur systeme zur tiefkuhlkonservierung
RU2200919C2 (ru) * 1999-04-27 2003-03-20 Ростовский-На-Дону Государственный Научно-Исследовательский Противочумный Институт Способ изоляции патогенного биоматериала при криоконсервации
GB2520521A (en) * 2013-11-22 2015-05-27 Stratec Biomedical Ag Universal Rack System

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2579733B1 (fr) * 1985-03-26 1987-11-20 Air Liquide Dispositif de stockage de tubes dans un recipient cryogenique
US4771900A (en) * 1987-04-09 1988-09-20 Nalge Company Storage rack for box-like container
DE29508438U1 (de) * 1995-05-20 1995-09-21 Bäumer, Robert, 48282 Emsdetten Vorrichtung zum Lagern von Rückstellproben
DE19716913A1 (de) * 1997-04-23 1998-11-05 Mingers Bernd Dipl Ing Modulare Lagervorrichtung zur tiefkalten Aufbewahrung von mit tiefgefrorener Zellsuspension befüllten, flächigen Kunststoffbeuteln
DE19725641C2 (de) * 1997-06-18 1999-06-10 Messer Griesheim Gmbh Vorrichtung zur tiefkalten Lagerung von pharmazeutischen Proben
DE10324397A1 (de) * 2003-05-28 2005-01-20 Hte Ag The High Throughput Experimentation Company Modulares Probenhalterungssystem
FR2927163B1 (fr) * 2008-01-31 2012-12-28 Air Liquide Panier de rangement pour conteneur cryogenique, module elementaire et procede de realisation du panier
KR101064321B1 (ko) 2009-04-03 2011-09-14 주식회사 비스 액체질소용기 시료보관용 랙
GB2492562A (en) * 2011-07-05 2013-01-09 Tully Marks Innovations Ltd Support apparatus and method of transporting an item

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US774879A (en) * 1902-09-05 1904-11-15 William G Hullhorst Instrument-holder for dentists.
US1093677A (en) * 1910-03-01 1914-04-21 Frank M Ashley Inkstand.
US2465644A (en) * 1944-10-25 1949-03-29 Lyman W Graves Battery case
US2730423A (en) * 1953-05-22 1956-01-10 Joseph P Mock Cabinet drawer stop construction
US3082050A (en) * 1960-12-13 1963-03-19 Arthur F Baxter Portable cabinet
US3327885A (en) * 1964-10-06 1967-06-27 Phillips Petroleum Co Bottle carrier
US3599865A (en) * 1968-08-14 1971-08-17 Nordisk Ventilator Thermohydraulic control device

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1665681A (en) * 1923-02-03 1928-04-10 Charles B Telling Ice-cream-brick container
FR1112529A (fr) * 1954-10-12 1956-03-15 Emballage
FR1118144A (fr) * 1954-12-31 1956-05-31 Emballage
FR1229879A (fr) * 1959-03-23 1960-09-12 Classeur de tubes ou récipients analogues en forme de boîte ou étui, notamment pour traitements thérapeutiques
US3103278A (en) * 1960-10-10 1963-09-10 Allied Chem Vertical and lateral interlocking packing case
US3245573A (en) * 1961-01-17 1966-04-12 Plasticase Inc Beverage bottle carrier
US3160306A (en) * 1962-03-30 1964-12-08 Phillips Petroleum Co Storage and transportation case
US3184071A (en) * 1962-12-12 1965-05-18 Eastman Kodak Co Plastic case for containers
DE1486219A1 (de) * 1964-01-09 1969-04-10 Blendax Werke Schneider Co Tubenbehaelter
FR1454447A (fr) * 1965-07-29 1966-02-11 Boîte à tiroir avec dispositif de blocage du tiroir et bande de garantie
DE2528152A1 (de) * 1975-06-24 1977-01-20 Ratiomed Gmbh Vorrichtung fuer die aufnahme von probetraegern
US3987891A (en) * 1975-07-07 1976-10-26 Plastic Research Products, Inc. Moisture proof safety container for pills and the like
US4154795A (en) * 1976-07-23 1979-05-15 Dynatech Holdings Limited Microtest plates
FR2461216A1 (fr) * 1979-07-10 1981-01-30 Saelens Bernard Boites de rangement pour congelateurs

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US774879A (en) * 1902-09-05 1904-11-15 William G Hullhorst Instrument-holder for dentists.
US1093677A (en) * 1910-03-01 1914-04-21 Frank M Ashley Inkstand.
US2465644A (en) * 1944-10-25 1949-03-29 Lyman W Graves Battery case
US2730423A (en) * 1953-05-22 1956-01-10 Joseph P Mock Cabinet drawer stop construction
US3082050A (en) * 1960-12-13 1963-03-19 Arthur F Baxter Portable cabinet
US3327885A (en) * 1964-10-06 1967-06-27 Phillips Petroleum Co Bottle carrier
US3599865A (en) * 1968-08-14 1971-08-17 Nordisk Ventilator Thermohydraulic control device

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525512A (en) * 1992-08-18 1996-06-11 Robocon Labor Und Industrieroboterges M.B.H. Incubator
EP1012499A4 (de) * 1996-01-30 2000-07-05 Organogenesis Inc Vorrichtung zur eiskristallbildung fur systeme zur tiefkuhlkonservierung
RU2200919C2 (ru) * 1999-04-27 2003-03-20 Ростовский-На-Дону Государственный Научно-Исследовательский Противочумный Институт Способ изоляции патогенного биоматериала при криоконсервации
GB2520521A (en) * 2013-11-22 2015-05-27 Stratec Biomedical Ag Universal Rack System

Also Published As

Publication number Publication date
EP0143306B1 (de) 1988-11-23
ES291667U (es) 1986-05-01
DE3342489C2 (de) 1986-10-23
ES291667Y (es) 1987-01-16
ZA849131B (en) 1985-09-25
EP0143306A3 (en) 1986-03-12
EP0143306A2 (de) 1985-06-05
ATE38892T1 (de) 1988-12-15
DE3342489A1 (de) 1985-06-05

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Legal Events

Date Code Title Description
AS Assignment

Owner name: MESSER GRIESHEIM GMBH, FRANKFURT/MAIN, GERMANY A C

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:VOLKER, WOLFGANG;THOMA, KLEMENS;REEL/FRAME:004601/0492

Effective date: 19841015

Owner name: MESSER GRIESHEIM GMBH, A COMPANY OF GERMANY, GERMA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:VOLKER, WOLFGANG;THOMA, KLEMENS;REEL/FRAME:004601/0492

Effective date: 19841015

FPAY Fee payment

Year of fee payment: 4

REMI Maintenance fee reminder mailed
LAPS Lapse for failure to pay maintenance fees
FP Lapsed due to failure to pay maintenance fee

Effective date: 19951228

STCH Information on status: patent discontinuation

Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362