US4545237A - Apparatus for blood analysis - Google Patents

Apparatus for blood analysis Download PDF

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Publication number
US4545237A
US4545237A US06/575,927 US57592784A US4545237A US 4545237 A US4545237 A US 4545237A US 57592784 A US57592784 A US 57592784A US 4545237 A US4545237 A US 4545237A
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Prior art keywords
tubes
support means
support
containers
sealing
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Expired - Fee Related
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US06/575,927
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English (en)
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Gerard Poncept
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Individual
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Individual
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/04—Investigating sedimentation of particle suspensions
    • G01N15/05—Investigating sedimentation of particle suspensions in blood

Definitions

  • the present invention relates to an apparatus for medical analyses, particularly an apparatus for blood analyses to determine the sedimentation rate of corpuscles, particularly erythrocytes, and to a method for using the apparatus.
  • sedimentation rates are measured using a Westergreen tube or pipette, that is, a thin graduated tube open at both ends.
  • the technician first immerses such a tube in a tube or container of larger diameter containing a blood sample, then sucks up the blood from the upper end of the Westergreen tube to a predetermined upper reference graduation of the tube.
  • the lower end of the tube is then sealed and the tube is placed on a support. The operation is repeated successively for each sample tube.
  • the present invention provides an apparatus offering the same advantages as the apparatus described in the prior application, particularly as to safety to the technician, while being of simplified construction and operation, particularly in avoiding the use of a suction device.
  • the apparatus according to the invention is essentially characterized by the fact that it includes a first support means for supporting several graduated Westergreen tubes open at both ends, with their axes vertical, and horizontally spaced apart on the support means, each of the Westergreen tubes having a lower end of enlarged section, which can be tubular, but preferably diverges downwardly.
  • a second support means has a number of tubes or containers of larger diameter than the lower ends of the tubes mounted on the first support means and which receive a blood sample, the containers being horizontally spaced on the said second support means so the Westergreen tubes are vertically aligned with the containers.
  • the said first support means also has several closing and compressing members, each engaged in the diverging lower end of the Westergreen tubes.
  • the two support means are movable vertically with respect to each other between a first position in which the tubes on the first support means are vertically separated from the containers on the second support means, and a second position in which the lower ends of the tubes on the first support means are immersed in the containers on the second support means.
  • the closing and compressing members are themselves movably mounted on the first support means between a lower position spaced from the tubes on the first support means, and an upper position in contact with the inner wall of the tubes, the movement of the closing and compressing members between the lower and upper portions causing, when the support means are in their said second position, the flow or pumping of a predetermined quantity of the blood sample from the containers on the second support means into the tubes on the first support means.
  • the closing and compressing members comprise disks whose diameters correspond to the enlarged diameter of the lower portion of the tubes, when this latter is tubular.
  • the diameters of the disks are between the diameter of the mouth and the main tubular body portion of the Westergreen tubes, and the disks are of an elastically deformable material.
  • each of the disk shaped members is connected to a curved or U-shaped lower end of a rod which is movable vertically along the first support means, the rods being connected, preferably at their upper ends, to a support or operator which is movable vertically with respect to the first support means.
  • the support means are made in the form of cylinders or drums of circular section and the tubes are mounted around the periphery of the cylinders, the rods with the closing and compressing disks then being connected, at their upper end, to a rim or ring mounted to be moved vertically with respect to the cylinder of the first support means, advantageously by a screw thread mechanism which allows fine control of the vertical movement of the ring relative to the first support cylinder.
  • the apparatus according to the invention advantageously includes a cleaning tank in which the entire apparatus can be immersed after the analyses are completed, the closing and compressing or pumping members then being operated to improve the circulation of the cleaning water in the tank, through the Westergreen tubes.
  • FIG. 1 is an exploded perspective view of one embodiment of the apparatus according to the invention
  • FIGS. 2 to 4 are side views showing schematically, the apparatus of FIG. 1, in three operating positions;
  • FIGS. 5 and 6 are enlarged views in section of the lower end of a Westergreen tube in positions corresponding to the positions of the apparatus in FIGS. 3 and 4, respectively.
  • the apparatus according to the invention shown on FIG. 1 basically includes two cylinders 1 and 2 of circular section.
  • the upper cylinder 1 is a sliding fit on lower cylinder 2, the two cylinders thus being mounted concentrically around an axle 3.
  • Upper cylinder 1 supports a plurality of identical Westergreen tubes 4, for example, twenty-five in number, the tubes 4 being vertical, and spaced apart around the periphery of cylinder 1.
  • Each tube 4 has a main tubular portion 4a extended at the lower end by a larger flared or diverging portion 4b in the shape of an inverted funnel.
  • the lower ends of the tubes are all in the same horizontal plane perpendicular to the axis of cylinder 1.
  • Each tube 4 is graduated and preferably, there is also a corresponding graduation (not shown) on the wall of cylinder 1.
  • crown 5 At the upper portion of cylinder 1 there is a support in the form of a crown or cover 5 having a peripheral rim.
  • Crown 5 is movable vertically with respect to cylinder 1, advantageously by means of a screw 6 having a knurled adjusting knob, and passing through a threaded nut (not shown) fixed to the center of cover 5.
  • the lower end of screw 6 is connected to a bearing fixed to cylinder 1, and at its center, so that turning the screw moves cover 5 up or down relative to cylinder 1.
  • the screw is connected to the bearing for rotation but against axial movement, so the screw couples the cover to the cylinder 1.
  • Gripping handles 7 are provided on the cover 5 (only one being shown), so that the cylinder 1 can be lifted with these handles.
  • cover 5 At the rim at the periphery of cover 5 are fastened metal rods 8, corresponding in number to the number of Westergreen tubes 4, each of the rods 8 being bent to provide U-shaped lower ends 9, and having at the end of this bent portion, as is shown at FIGS. 5 and 6, an elastically deformable disk 10 of circular section.
  • the disks 10 mounted at the lower ends of rods 8 constitute, as will be explained below, sealing members for the lower end of the Westergreen tubes, and flow causing or pumping members to cause a predetermined quantity of blood sample to flow upwardly into the tubes 4.
  • Lower cylinder 2 includes a base 11 and an annular flange 12 on which are mounted blood sample test tubes or containers 13.
  • the number of containers 13 equals the number of Westergreen tubes 4 of first cylinder 1, that is, twenty-five in this embodiment.
  • a mechanism including diametrically extending rods or pins 14 fixed to the wall of cylinder 1, and projecting inwardly, as shown at FIG. 1.
  • the rods or pins extend into and can slide in diametrically opposed slots 15 formed in the wall of lower cylinder 2, each slot being generally C-shaped and having one vertical portion and two spaced apart horizontal portions.
  • cylinder 1 is first placed in its upper position with respect to cylinder 2 and containers 13, containing the blood samples, are placed vertically below the respective tubes 4, on flange 12 of cylinder 2.
  • Flange 12 can have cup-like sockets to assure vertical alignment of the containers 13 with tubes 4.
  • Cylinder 1 is then lowered with respect to cylinder 2 to the position shown at FIG. 3 in which the lower end of each Westergreen tube 4 of cylinder 1 is immersed in a container 13 on flange 12 of cylinder 2.
  • crown 5 is lifted with respect to cylinder 1 to lift rods 8 relative to cylinder 1 to the position shown at FIG. 4.
  • the ascent of disks 10 at the ends of the lower curved parts 9 of rods 8 confines a quantity of blood in the lower diverging ends 4b of the tubes when the disks first engage the inside of the diverging ends 4b.
  • Further upward movement of rods 8 causes the disks 10 to deform and slide upwardly along the interior wall of the diverging portions 4b to force blood upwardly into the tubular pipette portion 4a of the Westergreen tubes, the respective diameters of the tubes and the diverging portions, and the extent of movement of rim 5 being such that the blood sample in each Westergreen tube reaches a starting reference level near the upper portion of each tube. Cylinder 1 can then be lifted to the position shown at FIG. 4.
  • the apparatus is thus placed in the measuring position and the sedimentation level of the red blood corpuscles in tubes 4 can be noted at appropriate intervals by reading either the graduations on each of the tubes, or by reference to the graduations of the measurement scale which can be provided on the upper cylinder 1.
  • disks 10 are disengaged from tubes 4 by turning screw 6 to lower cover 5 and containers 13 are removed and the whole apparatus is placed in a tank of washing water in which tubes 4 can be flushed by circulating water in the tubes by alternating movement of rods 8 via rim 5.
  • the analysis can be done when the cylinder 1 is in its lower position with respect to cylinder 2, by not lifting the cylinder to the position of FIG. 4, after raising the cover by turning screw 6.
  • the upper ends of rods 8 can be pivotally connected to the rim of the cover so the disks 10 are self-centering in the lower ends 4b, as the disks are lifted.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
US06/575,927 1983-02-02 1984-02-01 Apparatus for blood analysis Expired - Fee Related US4545237A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8301644A FR2540250A1 (fr) 1983-02-02 1983-02-02 Appareil d'analyses sanguines et procede pour sa mise en oeuvre
FR8301644 1983-02-02

Publications (1)

Publication Number Publication Date
US4545237A true US4545237A (en) 1985-10-08

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ID=9285544

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US06/575,927 Expired - Fee Related US4545237A (en) 1983-02-02 1984-02-01 Apparatus for blood analysis

Country Status (6)

Country Link
US (1) US4545237A (enrdf_load_stackoverflow)
EP (1) EP0117182B1 (enrdf_load_stackoverflow)
AT (1) ATE27493T1 (enrdf_load_stackoverflow)
CA (1) CA1206857A (enrdf_load_stackoverflow)
DE (1) DE3463974D1 (enrdf_load_stackoverflow)
FR (1) FR2540250A1 (enrdf_load_stackoverflow)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3421955C2 (de) * 1984-06-13 1986-10-09 Walter Sarstedt Kunststoff-Spritzgußwerk, 5223 Nümbrecht Blutsenkungsvorrichtung
US4762849A (en) * 1985-10-15 1988-08-09 Merrell Dow Pharmaceuticals Inc. Cardiotonic alkanoylthiazolones

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2729971A (en) * 1952-05-10 1956-01-10 Stein Walter Apparatus for measuring sedimentation rate of blood
US3329179A (en) * 1963-11-13 1967-07-04 Permawick Company Extrusion apparatus and method
US3373601A (en) * 1964-08-05 1968-03-19 Monn Stanislaus Device for the analysis of the sinking speed of blood corpuscles in a calibrated tube
US3827286A (en) * 1971-07-29 1974-08-06 Gelman Instr Co Device for blood sedimentation rate estimation
US4197735A (en) * 1978-11-06 1980-04-15 Chase Instruments Corporation Blood sedimentation rate test means

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB726095A (en) * 1953-03-09 1955-03-16 Karl Freudenhammer An improved device for determining the erythrocyte sedimentation rate
NL7411204A (nl) * 1973-10-26 1975-04-29 Mapa Gmbh Gummi Plastikwerke Inrichting voor het bepalen van erythrocyten- -bezinkingsreacties in bloed (ebr) of voor het pipetteren.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2729971A (en) * 1952-05-10 1956-01-10 Stein Walter Apparatus for measuring sedimentation rate of blood
US3329179A (en) * 1963-11-13 1967-07-04 Permawick Company Extrusion apparatus and method
US3373601A (en) * 1964-08-05 1968-03-19 Monn Stanislaus Device for the analysis of the sinking speed of blood corpuscles in a calibrated tube
US3827286A (en) * 1971-07-29 1974-08-06 Gelman Instr Co Device for blood sedimentation rate estimation
US4197735A (en) * 1978-11-06 1980-04-15 Chase Instruments Corporation Blood sedimentation rate test means

Also Published As

Publication number Publication date
CA1206857A (fr) 1986-07-02
EP0117182B1 (fr) 1987-05-27
DE3463974D1 (en) 1987-07-02
FR2540250B1 (enrdf_load_stackoverflow) 1985-04-12
EP0117182A1 (fr) 1984-08-29
ATE27493T1 (de) 1987-06-15
FR2540250A1 (fr) 1984-08-03

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