US3980083A - Medicament infusor unit - Google Patents

Medicament infusor unit Download PDF

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Publication number
US3980083A
US3980083A US05/549,563 US54956375A US3980083A US 3980083 A US3980083 A US 3980083A US 54956375 A US54956375 A US 54956375A US 3980083 A US3980083 A US 3980083A
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United States
Prior art keywords
piston
vial
infusor
container
diaphragm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US05/549,563
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English (en)
Inventor
Phillip M. Elliott
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Illinois Tool Works Inc
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Illinois Tool Works Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illinois Tool Works Inc filed Critical Illinois Tool Works Inc
Priority to US05/549,563 priority Critical patent/US3980083A/en
Priority to ZA760492A priority patent/ZA76492B/xx
Priority to CA244,595A priority patent/CA1077794A/en
Priority to EG7376A priority patent/EG11922A/xx
Priority to DE19762605291 priority patent/DE2605291A1/de
Priority to GB3188578A priority patent/GB1540882A/en
Priority to SE7601563A priority patent/SE7601563L/xx
Priority to BR7600866A priority patent/BR7600866A/pt
Priority to FR7603916A priority patent/FR2300578A1/fr
Priority to AU11054/76A priority patent/AU495737B2/en
Priority to IT2011376A priority patent/IT1055234B/it
Priority to GB552476A priority patent/GB1540881A/en
Priority to ES445178A priority patent/ES445178A1/es
Priority to JP1407576A priority patent/JPS51106385A/ja
Application granted granted Critical
Publication of US3980083A publication Critical patent/US3980083A/en
Priority to BE7000899A priority patent/BE846896Q/xx
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2422—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/2429—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by telescoping of ampoules or carpules with the syringe body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3286—Needle tip design, e.g. for improved penetration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2200/00—General characteristics or adaptations
    • A61J2200/10—Coring prevention means, e.g. for plug or septum piecing members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
    • A61M2005/312—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula comprising sealing means, e.g. severable caps, to be removed prior to injection by, e.g. tearing or twisting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/288—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S604/00—Surgery
    • Y10S604/90—Telltale showing entry of blood into body inserted conduit

Definitions

  • such devices provide minimal drug contact surfaces which, up to the moment of aspiration for a show of blood when a venipuncture is necessary, are not exposed to the drug, but which immediately upon aspiration pull their plunger or plug back across vial surfaces which have been exposed to the air and which consequently can subject the infused drugs to aerobic contamination.
  • Another object of this invention is to provide a device which is capable of giving a readily observable indication that a venipuncture has been made by a show of aspirated blood within the device that does not necessitate drawing the blood back into the drug containing vial.
  • An additional object to the invention is to provide an infusor unit which, once a venipuncture or needle entry is made, permits the injection of several vials of the same or varying drug content by having the ability to disengage the vial without or with minimum aspiration of blood or body fluid into the removed vial.
  • Aspirating in a unit-dose system should occur only at desired times. This is accomplished in the present invention by keeping the retentive force of the piston or plug to the vial wall at a control level. By controlling the drag on the vial wall and retention of the infusor unit probe to the plug, a low level of aspirating pull can be exerted against the plug without disengagement. An abruptly higher pull disengages the probe from the plug leaving it in the vial without aspiration. The plug, with the probe removed, reseals the vial or simply remains at the bottom of the empty vial ready for discard. Meanwhile, the infusor unit, with the cannula still implanted in the venipuncture, is ready to receive and engage a fresh vial.
  • a secondary advantage of the disengagement of the probe from the plug or piston is its non-reuse. If the plug were designed to aspirate easily it would encourage use of aspirating drugs from a bulk container. Making aspiration difficult encourages single use and disposal with its inherent sterile advantages. Since the device is intended and designed for single usage the disengagement of the plug from the probe defeats mis-use, re-use, making the package more security conscious and substantially tamper-proof.
  • FIG. 1 is a perspective view of a preferred embodiment of the present invention in its assembled relationship
  • FIG. 2 is an exploded view of the various elements of the preferred embodiment
  • FIG. 3 is a side elevational view in partial section of the device shown in FIG. 2 in assembled relationship;
  • FIG. 4 is an end view of the infusor unit shown in FIGS. 1 through 3;
  • FIG. 5 is an expanded elevational view in partial section of the probe of the infusor unit
  • FIG. 6 is an elevational view in partial section of the probe, piston and vial in pre-assembled relation
  • FIG. 7 is an elevational view in partial section showing the probe as it makes its initial penetration of the diaphragm in the piston bore;
  • FIG. 8 is an elevational view in partial section showing the probe in its final seated position at the beginning of the evacuation of material from the vial;
  • FIG. 9 is an exploded view of the elements making up a second embodiment of the infusor unit.
  • FIG. 10 is an elevational view in partial section showing the pre-assembly of the probe with the piston of said second embodiment
  • FIG. 11 is an elevational view in partial section showing the probe of the second embodiment in final seated position
  • FIG. 12 is an elevational view in partial section of a third embodiment of the present invention.
  • FIG. 13 is an end view of the third embodiment as taken along Line 13--13 of FIG. 12;
  • FIG. 14 is an elevational view in partial section of an alternate design for the probe
  • FIGS. 15 and 16 are variations on the interior bore chamber of the piston used with the present invention.
  • FIG. 17 is an elevational view in partial section of a device using the teachings of this present invention for the purpose of having two vials for storage of liquid and dry materials which cannot be pre-mixed until immediately before injection;
  • FIG. 18 is an elevational view in partial section of the device shown in FIG. 17 when the materials have been mixed;
  • FIG. 19 is a plan view in partial section of a filtration device for use with the present invention.
  • FIG. 20 is a side view in partial section of the device shown in FIG. 19.
  • a linear activated medicament infusor unit 10 includes a tubular container 12 open at one end, a resilient plug or piston 14, and a substantially rigid hollow tubular infusor means 16 carried by a frame having a sharpened cannula 18 suitably supported and in communication with one end of the tubular infusor means 16.
  • the infusor 16 includes a framework having a base 20 and a pair of sidewalls 22 symetrically placed on either side of the axis of the frame.
  • the sidewalls 22 are reinforced by ribbing 24 which can be eliminated in smaller model designs.
  • the upper or opposite end of the sidewalls 22 are joined by a yoke 26 having a central aperture 28 for acceptance of the vial 12 and a pair of laterally extending flanges or wings 30 for grasping by the index and middle finger of the operator.
  • the reinforcing ribs 24 are curved at their upper extremity for accommodation of the operator's fingers.
  • the cannula 18 is insert-molded centrally of the base 20 and gripped at spaced points 32 and 34, the latter being accomplished by use of spaced walls 36 which re-enter and join at point 34.
  • This technique permits the grasping of the cannula 18 to more positively locate it during the injection molding of the infusor.
  • the bridge formed by walls 36 and re-entrant portion 34 carry a transparent tubular member 38 having a hollow interior bore 39 larger in diameter than the cannula 18 and in communication therewith. This forms a transparent chamber which will be discussed hereinafter.
  • a probe or spike 40 At the upper end of tubular member 38 is a probe or spike 40 which can be best seen in FIG. 5.
  • the probe 40 in this embodiment includes a frustoconical portion 42 having a pre-determined major and minor diameter which is spaced a short distance from the end of the tubular member 38.
  • the end is tapered to provide a sharp point 44 with a large opening to the interior bore 39 of tubular member 38.
  • annular enlargement 46 for purposes best set forth hereinafter.
  • Spaced axially from the cone 42 is a tapered annular flange 48 whose function will be described hereinafter. It should be noted that the distance between the major diameter or frustoconical portion 42 and the flange 48 is controlled.
  • the major diameter of the frustoconical portion 42 forms a shoulder 50 in opposition to the flange 48, for purposes best set forth hereinafter.
  • the vial 12 is a tubular member which is shown to be cylindrical in this embodiment but could be square, elliptical, or any other suitable cross sectional configuration.
  • the vial is open at one end 60 and includes a necked in portion formed by a rib 62 having a pre-determined axial extent and an external groove 64.
  • the rib 62 has a wall thickness substantially equal to the balance of the vial but could be replaced by other suitable spaced protuberance means to form the necked in portion.
  • the plug or piston 14 is a resilient elastomeric member including a body 70 having a plurality of rings equal to or slightly larger than the internal measurement of the vial 12 and complementary to its cross-sectional shape, in this instance, cylindrical.
  • the rings are axially spaced and in the present embodiment there is a first ring 72 adjacent the outer end of the piston 14; a second ring 74 intermediate the extremities of the piston and spaced from the first ring 72 a distance substantially equal to the axial extent of rib 62; and a third ring 76 at the inner or opposite end.
  • the inner end face 78 is generally concave and leads in its center portion to the bore 80.
  • the bore 80 is sealed by a transverse diaphragm 82 and has a tapered entryway 84 at the outer end and an inwardly directed annular rib 86 which restricts the bore 80 and provides a pair of oppositely directed shoulders 88 and 90.
  • the inside shoulder 88 and the diaphragm 82 serve to form a chamber 92 which is generally frustoconical in cross section and equal to or slightly larger in volume than the frustoconical portion 42 of the probe, for purposes best set forth hereinafter.
  • the rib 86 has an internal transverse measurement equal to or less than the minor diameter of the frustoconical portion 42.
  • the piston 14 is assembled with the vial 12 with the first and second ring 72 and 74 disposed on opposite sides of the rib 62.
  • the probe 40 is introduced into the tapered entryway 84 and through the aperture formed by rib 86 resulting in a lateral compression of the resilient rib 86 until such time as the annular rib or ring 46 enters the chamber 92 and rests on the shoulder 88.
  • the axial disposition of the various parts on the probe, including point 44, is such that the bevelled point 44 will distort the diaphragm 82 and the frustoconical portion 42 will cause the piston 14 to bulge sideways into intimate engagement by increase of the surface area of rib 72 and the intermediate portion of the body 70 in contact with the rib 62 and its outwardly-facing shoulder 63.
  • the probe can be pre-assembled with the closed vial for storage prior to usage, as will be set forth hereinafter.
  • the ring-like yoke 26 is provided with a pair of depending resilient members or fingers 100, as best seen in FIGS. 2 and 3. These fingers 100 will engage in the grooves 64 and prevent inadvertent disassembly from this pre-assembled position.
  • the flange 48 is then positioned against the outer shoulder 90 and due to the volume of the chamber 92, a major amount of the lateral forces incurred in the telescoping operation are removed and the piston 14 reverts to substantially its initial shape.
  • the locking action incurred by the introduction of the probe 40 is primarily due to the side pressure against the vial by the frustoconical configuration of part 42 and its associated flange 48 which keeps the piston stationary with respect to the vial while the probe is being advanced through the piston. It is this combination of drag, or holding power, between the piston and vial, as well as a partial hydraulic lock, which holds the piston while the diaphragm is being punctured.
  • the cannula is protected by a cover 110 which can, if desired, be integrally molded to the needle and provided with a fracture point 112 at its juncture to the frame and, at the opposite end, as illustrated, can be closed by crimping, by suitable means such as heat or ultrasonics, to provide a flat portion 114 to seal off the free or sharpened end of the cannula for the function of maintaining aseptic conditions as well as protecting the sharpness of the ground end.
  • a cover 110 can, if desired, be integrally molded to the needle and provided with a fracture point 112 at its juncture to the frame and, at the opposite end, as illustrated, can be closed by crimping, by suitable means such as heat or ultrasonics, to provide a flat portion 114 to seal off the free or sharpened end of the cannula for the function of maintaining aseptic conditions as well as protecting the sharpness of the ground end.
  • the entire assembly can be shipped with the vial pre-assembled to the probe or, alternatively, can be packaged separately.
  • the nurse or doctor can preassemble, if it has not already been so done, by inserting the vial into the cylindrical yoke 26 and by a simple axial pressure, seat the probe in the position shown in FIG. 6. Further axial force on the closed end of the vial 12 will puncture the diaphragm 82, as seen in FIG. 7, until the probe is seated in the chamber 92. With the plug being distorted laterally until the probe is seated, the present design permits the point to continue penetration well beyond the minimum puncture to insure establishment of clear fluid flow.
  • the chamber 92 also gives rise to a sudden drop in penetration force, creating a good detent feel for tactile feedback that the puncture has been made. If it is found necessary to use the drug, the operator will grasp the flattened portion 114 of the needle cover 110, fracture the juncture 112 by twisting, and axially remove the cover 110 to provide a sterilized cannula that is only momentarily exposed to aerobic conditions. Additionally, by carrying out the puncture of the diaphragm before breakage of the needle seal it is possible to eliminate any possibility of hydraulic discharge caused by pressures developed during penetration of the spike into the piston.
  • this product is capable of being activated for use with only one motion, namely, jamming the vial into the probe penetrating point. No "coupling up” is necessary nor are there any magical rotational forces required to insure proper usage.
  • a venipuncture is performed, after air has been cleared from the tubular portion 38 and the cannula 18, aspiration, by slow withdrawal of the vial 12 will reveal that a good venipuncture has been made since the blood can be seen in the transparent tubular portion 38 without introduction of such blood into the vial 12. This is particularly important where the medicament in the vial 12 may be viscous in nature.
  • the clear tubular portion 38 could be extended to the base 20 and its central portion 32 and communication provided through a Leur fitting 166 and the inserted molded cannula 18 not provided.
  • An independent cannula having a female Leur fitting could then be utilized should this be found desirable.
  • the function of the device would remain substantially identical.
  • the plug 14 was provided with three substantially identical annular ring members 72-76 which cooperated with the rib 62 for maintenance of the plug 14 relative to the vial 12 during introduction of the probe 40.
  • FIGS. 9 through 11 it can be seen that a similar plug 14a can be used with a vial 12a having a generally smooth interior wall that does not have an internal rib, as was found in the first embodiment.
  • the disposition of the entry 84a, the rib 86a, the chamber 92a, and the diaphragm 82a, are substantially identical to the first embodiment.
  • the major difference in this embodiment is the disposition and axial extent of the annular rings 120, 122 and 124.
  • the ring 122 is positioned immediately adjacent to the first ring 120 and is separated therefrom by a minimal groove 121.
  • a ring 120 having a slightly larger diameter than ring 122, is positioned atop the outermost open end of vial 12a, as best seen in FIG. 10.
  • the introduction of the probe 40a causes a lateral swelling until the ring 120 sits in overlying relationship.
  • the piston due to its excessive drag and the overriding ring 120 is substantially locked relative to the sidewall of the vial 12a, thereby permitting puncture of the diaphragm 82a by the tip 44a. Operation of this device is substantially identical to the first embodiment.
  • each of the two previous embodiments have been described as having imperforate diaphragms 82 and 82a.
  • a diaphragm 130 as seen in FIGS. 12 and 13, which is pre-slit.
  • the point 44b in this embodiment is not cut on the bias but rather is slightly tapered and provided with a blunt nose 132 for opening the slit diaphragm when the probe 40b is moved axially relative to the piston 14b to seat the frustoconical portion 42b within the chamber 92b.
  • the operation for pre-assembly, injection, etc. is substantially identical to the previous two embodiments.
  • the shallow undercut beneath the corner of rib 86 will not release the prove during aspiration unless a high force rapidly applied will cause this rib 86 to bend downwardly and compress outwardly, as by beam loading, to bend the short arm out of the way.
  • aspiration is possible when the vial is withdrawn slowly but will result in removal of the piston from the probe if a quick force is applied in a retrograde direction to the vial.
  • the probe can be varied by undercutting two sides of the frustoconical section 42d as seen in FIG. 14, to provide a pair of resilient arms 140 that will flex during insertion and seat against the shoulder 88 in a positive fashion which will substantially prevent removal from the chamber 92.
  • the vial 12e is substantially identical to the embodiment shown in FIGS. 9 through 11 with a piston 14e of similar configuration.
  • This vial would be filled with a liquid solution, such as water, and preferably would be a glass vial.
  • a second vial 150 has its lower end in communication with a probe 152 having a configuration substantially identical to the probe used in the embodiments shown in FIGS. 1 through 11.
  • the vial 150 has a diameter equal to or less than the internal diameter of vial 12e and would generally contain and be manufactured from a material compatible with the dry crystals of the drug which must be hydrated.
  • the probe 152 is forced through into pierced relationship with the piston 14e in vial 12e.
  • Axial telescoping of vial 150 into vial 12e results in the introduction of the liquid in vial 12e into vial 150, in a manner shown in FIG. 18.
  • the two vials would initially be activated in the position shown in FIGS. 17 and 18.
  • the operator preferably should hold the two vials in the position of FIG.
  • the piggy-back pre-assembly of FIG. 17 could be packaged in an attractive tubular cover, not shown, that would lock the two vials in this position, provide a tamperproof cover and yet permit axial collapse for telescoping the vials for mixing before exposure to atmospheric conditions.
  • the piggyback telescoped vials would then be inserted into an infusor unit and the hydrated medicament could then be injected into the patient in the fashion described hereinbefore.
  • the contemplated filter includes a strip of porous filter material which is bent back upon itself to cover the end of the cannula 118 at the point it leaves the yoke 34 and enters the hollow tubular portion 38.
  • the filter 160 would be bound along its free open edges 162 by the plastic materials forming the tubular portion 38 and the bridge 34, thereby forming an envelope which encloses the free end of cannula 118. This can be accomplished at the time of insert molding the needle into the framework of the infusor unit.
  • the fabrication of the infusor unit with its framework, insert molded cannula and cover can be accomplished on standard injection molding equipment.
  • the cannula is adequately held intermediate its length so that damage is not done to the ground point.
  • the cover can be simultaneously molded and sealed at a secondary operation. This eliminates subsequent processing, such as glueing or assembly of the needle to the end of a framework, and, assuming that the parts are "clean", sterilization of the drug container and infusor attached together sterilizes all fluid conducting passages and all primary and secondary drug contact surfaces.
  • these surfaces will remain absolutely sterile until the moment of use when the needle is exposed to air seconds before venipuncture.
  • Using the fewest possible parts and attaining the maximum variable end configurations makes this item a broadly based economical product. The only cause for component difference requiring separate tooling is dosage size variation and needle size. However, they add significant substitute possibilities to the overall system.
  • the presence of the transparent tubular element 38, forming a chamber larger than the cannula provides a ready visible observation of an accurate venipuncture and substantially lowers the pressure of the blood, thereby substantially reducing the possibility of the introduction of blood into the drug container. Additionally, more than one drug can be administered sequentially to the same patient without removal of the cannula from the venipuncture and when telescoped vials of the type described herein are utilized, drugs having a short life span following hydration can be pre-assembled to a needle in a rapid manner.
  • the infusor unit can be fabricated from known transparent thermoplastic materials such as polypropylene.
  • the pistons or plugs are commonly made from an elastomeric material such as rubber while the vials can be fabricated from materials which are compatible with the drugs stored therein.
  • glass vials will be utilized with the exception of where piggyback installations require the molding of a probe and aperture at the normal enclosed end of the vial.
  • a suitable plastic material compatible with the drug stored therein in its dehydrated condition can be used.
  • vacuum formed packaging commonly known as blister-packs will provide the necessary sterility for storage and handling of devices of the type contemplated herein.

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US05/549,563 1975-02-13 1975-02-13 Medicament infusor unit Expired - Lifetime US3980083A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
US05/549,563 US3980083A (en) 1975-02-13 1975-02-13 Medicament infusor unit
ZA760492A ZA76492B (en) 1975-02-13 1976-01-28 Medicament infusor unit
CA244,595A CA1077794A (en) 1975-02-13 1976-01-30 Medicament infusor unit
DE19762605291 DE2605291A1 (de) 1975-02-13 1976-02-11 Infusionsspritze
EG7376A EG11922A (en) 1975-02-13 1976-02-11 Medicament infusor unit
FR7603916A FR2300578A1 (fr) 1975-02-13 1976-02-12 Dispositif d'injection de medicaments
SE7601563A SE7601563L (sv) 1975-02-13 1976-02-12 Injektionsspruta
BR7600866A BR7600866A (pt) 1975-02-13 1976-02-12 Unidade de infusao de medicamento;embolo em forma de pistao;tubo adaptado para ser associado com um pistao elastomerico;recipiente para medicamento;e unidade seco-liquida premontada
GB3188578A GB1540882A (en) 1975-02-13 1976-02-12 Medicament infuser units
AU11054/76A AU495737B2 (en) 1975-02-13 1976-02-12 Medicament infusor unit
IT2011376A IT1055234B (it) 1975-02-13 1976-02-12 Unita di iniezione per farmaci
GB552476A GB1540881A (en) 1975-02-13 1976-02-12 Medicament infuser units
JP1407576A JPS51106385A (ja) 1975-02-13 1976-02-13
ES445178A ES445178A1 (es) 1975-02-13 1976-02-13 Mejoras introducidas en una unidad infusora de medicamentos.
BE7000899A BE846896Q (nl) 1975-02-13 1976-10-01 Infusie-eenheid voor het toedienen van een geneesmiddel,

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/549,563 US3980083A (en) 1975-02-13 1975-02-13 Medicament infusor unit

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US3980083A true US3980083A (en) 1976-09-14

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US05/549,563 Expired - Lifetime US3980083A (en) 1975-02-13 1975-02-13 Medicament infusor unit

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US (1) US3980083A (ja)
JP (1) JPS51106385A (ja)
BE (1) BE846896Q (ja)
BR (1) BR7600866A (ja)
CA (1) CA1077794A (ja)
DE (1) DE2605291A1 (ja)
EG (1) EG11922A (ja)
ES (1) ES445178A1 (ja)
FR (1) FR2300578A1 (ja)
GB (2) GB1540882A (ja)
IT (1) IT1055234B (ja)
SE (1) SE7601563L (ja)
ZA (1) ZA76492B (ja)

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US4091811A (en) * 1976-11-15 1978-05-30 Baxter Travenol Laboratories, Inc. Needle cover
US4713062A (en) * 1985-05-29 1987-12-15 Vecta Glass Company Ltd. Ready to use syringe
US5236749A (en) * 1991-12-02 1993-08-17 Ewing William D Blister package
US5478324A (en) * 1993-02-19 1995-12-26 Medicorp Holding S.A. Prefilled syringe for storing and for transfer of liquid and sterile medicinal substances
WO1999036114A3 (en) * 1998-01-20 1999-10-07 Tecnologia S A S Di Valentino Device of the manual syringe type for proportioning and dispensing fluid or pasty products
WO2000043057A1 (en) 1999-01-21 2000-07-27 Tecnologia S.A.S Di Valentino Brazzale & C. A device for injecting a fluid product
US6146374A (en) * 1996-03-15 2000-11-14 Becton, Dickinson And Company Disconnect for medical access devices
US20050075604A1 (en) * 2003-10-07 2005-04-07 Lee Jong Woo Delivery apparatus for medical fluids in flat and round shape
US20050075607A1 (en) * 2003-10-06 2005-04-07 Lee Jong Woo Volume-regulating device for medical fluids
US20080058732A1 (en) * 2006-08-30 2008-03-06 Arthur Harris Continuous Feed Hypodermic Syringe with Self Contained Cartridge Dispenser
US20080114295A1 (en) * 2006-11-15 2008-05-15 Glynntech, Inc. Drug delivery device with sliding valve and methodology
US20080140007A1 (en) * 2006-12-11 2008-06-12 Glynntech, Inc. Drug delivery device and methodology
US20120006926A1 (en) * 2010-07-06 2012-01-12 Autoliv Asp, Inc. High seal retractor pretensioner piston
US8235951B2 (en) 2005-11-12 2012-08-07 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Attachment for a syringe or cartridge
US20140014210A1 (en) * 2012-07-13 2014-01-16 Becton Dickinson and Company Ltd. Medical Vial Access Device with Pressure Equalization and Closed Drug Transfer System and Method Utilizing Same
US20140052102A1 (en) * 2011-05-06 2014-02-20 Sanofi-Aventis Deutschland Gmbh Reuse Protection for Disposable Parts
US20140171831A1 (en) * 2012-12-17 2014-06-19 Johnny Dieu Clear/Translucent Tube Fluids Flash Display with Receiving Hub (Vacufly)
US20140276924A1 (en) * 2013-03-15 2014-09-18 Boston Scientific Scimed, Inc. Gel sweeper for residual stone fragment removal
US9101725B2 (en) 2012-06-25 2015-08-11 Becton Dickinson France Prefillable drug delivery device
CN105476750A (zh) * 2016-01-23 2016-04-13 王翠兰 鼓膜穿刺、鼓室内注射医疗装置
CN105496644A (zh) * 2016-01-23 2016-04-20 王翠兰 鼓膜穿刺、鼓室内注射医疗装置
CN105596145A (zh) * 2016-01-23 2016-05-25 王翠兰 鼓膜穿刺、鼓室内注射医疗装置
CN105726206A (zh) * 2016-01-23 2016-07-06 王翠兰 鼓膜穿刺、鼓室内注射医疗装置
RU189007U1 (ru) * 2017-03-20 2019-05-06 Федеральное государственное бюджетное образовательное учреждение высшего образования "Юго-Западный государственный университет" (ЮЗГУ) Шприц
CN110368302A (zh) * 2014-04-21 2019-10-25 贝克顿迪金森有限公司 与密闭式系统传送装置一起使用的隔膜器
CN113143759A (zh) * 2015-07-16 2021-07-23 西部制药服务以色列有限公司 用于安全的伸缩的卡扣配合在注射剂小瓶上的液体药物转移装置
US20230026744A1 (en) * 2021-07-20 2023-01-26 Alcon Inc. Infusion cannula

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WO1989004186A1 (en) * 1987-11-11 1989-05-18 Nixon, Ewan Plunger withdrawal aid for syringes
DE9002924U1 (de) * 1990-03-15 1990-05-17 Bayer Ag, 5090 Leverkusen Hohldorn aus Kunststoff
US6068011A (en) 1993-10-13 2000-05-30 Paradis; Joseph R. Control of fluid flow
EP0693949B1 (fr) * 1994-02-14 1998-05-06 Sanofi Module injecteur pour une seringue
IT233201Y1 (it) * 1994-03-24 2000-01-26 Bracco Spa Dispositivo a due componenti per la somministrazione di farmaci
KR960704591A (ko) * 1994-05-25 1996-10-09 메이어 가브리엘 의학 물질의 용액, 현탁액 또는 에멀션의 제제를 위한 장치(device for the preparation fo a solution. a suspension or an emulsion of a medicinal substance)
DE102014218414A1 (de) * 2014-09-15 2016-03-17 B. Braun Melsungen Ag Verschlussanordnung für ein Trägergehäuse eines medizinischen Fluidspeicher- und/oder -leitungssystems
CN107206164A (zh) 2015-01-09 2017-09-26 贝克顿·迪金森有限公司 输注转接器
CN111529386B (zh) * 2020-05-25 2021-03-02 吉林大学 一种心胸外科胸腔闭式引流患者用灭菌水更换装置

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US2693183A (en) * 1951-10-10 1954-11-02 Compule Corp Hypodermic syringe blood telltale
US2771879A (en) * 1954-09-09 1956-11-27 Jr Alvin B Salisbury Disposable syringe
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US3098482A (en) * 1958-01-07 1963-07-23 O'sullivan James Disposable syringe
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US3724460A (en) * 1968-11-14 1973-04-03 American Home Prod Disposable cartridge for admixing two components of injectable medicament
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US2448898A (en) * 1945-04-21 1948-09-07 Marshall L Lockhart Hypodermic needle
US2693183A (en) * 1951-10-10 1954-11-02 Compule Corp Hypodermic syringe blood telltale
US2771879A (en) * 1954-09-09 1956-11-27 Jr Alvin B Salisbury Disposable syringe
US2959170A (en) * 1957-12-26 1960-11-08 Ernest S V Laub Hypodermic syringe
US3098482A (en) * 1958-01-07 1963-07-23 O'sullivan James Disposable syringe
US3128766A (en) * 1962-06-15 1964-04-14 Mizzy Arnold Robert Medicinal syringe
US3376866A (en) * 1965-07-23 1968-04-09 Robert W. Ogle Medicament injector with attached vial
US3552387A (en) * 1968-07-16 1971-01-05 Peter A Stevens Combination syringe and vial
US3724460A (en) * 1968-11-14 1973-04-03 American Home Prod Disposable cartridge for admixing two components of injectable medicament
US3838689A (en) * 1970-11-04 1974-10-01 M Cohen Disposable syringe with slit valve
US3890972A (en) * 1973-09-25 1975-06-24 Abbott Lab Syringe injector with pop-top cap

Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091811A (en) * 1976-11-15 1978-05-30 Baxter Travenol Laboratories, Inc. Needle cover
US4713062A (en) * 1985-05-29 1987-12-15 Vecta Glass Company Ltd. Ready to use syringe
US5236749A (en) * 1991-12-02 1993-08-17 Ewing William D Blister package
US5478324A (en) * 1993-02-19 1995-12-26 Medicorp Holding S.A. Prefilled syringe for storing and for transfer of liquid and sterile medicinal substances
AU678573B2 (en) * 1993-02-19 1997-06-05 Medicorp Holding S.A. Prefilled syringe for storing and dispensing a sterile liquid drug
US6146374A (en) * 1996-03-15 2000-11-14 Becton, Dickinson And Company Disconnect for medical access devices
WO1999036114A3 (en) * 1998-01-20 1999-10-07 Tecnologia S A S Di Valentino Device of the manual syringe type for proportioning and dispensing fluid or pasty products
WO2000043057A1 (en) 1999-01-21 2000-07-27 Tecnologia S.A.S Di Valentino Brazzale & C. A device for injecting a fluid product
US7264610B2 (en) 2003-10-06 2007-09-04 Acemedical Co., Ltd. Volume-regulating device for medical fluids
US20050075607A1 (en) * 2003-10-06 2005-04-07 Lee Jong Woo Volume-regulating device for medical fluids
US20050075604A1 (en) * 2003-10-07 2005-04-07 Lee Jong Woo Delivery apparatus for medical fluids in flat and round shape
US7520868B2 (en) 2003-10-07 2009-04-21 Acemedical Co., Ltd. Delivery apparatus for medical fluids in flat and round shape
US8235951B2 (en) 2005-11-12 2012-08-07 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Attachment for a syringe or cartridge
US20080058732A1 (en) * 2006-08-30 2008-03-06 Arthur Harris Continuous Feed Hypodermic Syringe with Self Contained Cartridge Dispenser
US9233206B2 (en) * 2006-08-30 2016-01-12 Arthur Harris Continuous feed hypodermic syringe with self contained cartridge dispenser
US20080114295A1 (en) * 2006-11-15 2008-05-15 Glynntech, Inc. Drug delivery device with sliding valve and methodology
US7637889B2 (en) 2006-11-15 2009-12-29 Glynntech, Inc. Drug delivery device with sliding valve and methodology
US20100137833A1 (en) * 2006-11-15 2010-06-03 Glynn Kenneth P Methodology for drug delivery device with sliding valve
US8100853B2 (en) 2006-11-15 2012-01-24 Glynn Tech, Inc. Methodology for drug delivery device with sliding valve
US8382713B2 (en) 2006-12-11 2013-02-26 Kenergy Scientific, Inc. Drug delivery device and methodology
US20080140007A1 (en) * 2006-12-11 2008-06-12 Glynntech, Inc. Drug delivery device and methodology
US8770506B2 (en) * 2010-07-06 2014-07-08 Autoliv Asp, Inc. High seal retractor pretensioner piston
US20120006926A1 (en) * 2010-07-06 2012-01-12 Autoliv Asp, Inc. High seal retractor pretensioner piston
US20140052102A1 (en) * 2011-05-06 2014-02-20 Sanofi-Aventis Deutschland Gmbh Reuse Protection for Disposable Parts
US9101725B2 (en) 2012-06-25 2015-08-11 Becton Dickinson France Prefillable drug delivery device
US20140014210A1 (en) * 2012-07-13 2014-01-16 Becton Dickinson and Company Ltd. Medical Vial Access Device with Pressure Equalization and Closed Drug Transfer System and Method Utilizing Same
US10434034B2 (en) 2012-07-13 2019-10-08 Becton Dickinson and Company Ltd. Medical vial access device with pressure equalization and closed drug transfer system and method utilizing same
US9089474B2 (en) * 2012-07-13 2015-07-28 Becton Dickinson and Company Ltd. Medical vial access device with pressure equalization and closed drug transfer system and method utilizing same
US20140171831A1 (en) * 2012-12-17 2014-06-19 Johnny Dieu Clear/Translucent Tube Fluids Flash Display with Receiving Hub (Vacufly)
US20140276924A1 (en) * 2013-03-15 2014-09-18 Boston Scientific Scimed, Inc. Gel sweeper for residual stone fragment removal
US9775631B2 (en) * 2013-03-15 2017-10-03 Boston Scientific Scimed, Inc. Gel sweeper for residual stone fragment removal
CN110368302A (zh) * 2014-04-21 2019-10-25 贝克顿迪金森有限公司 与密闭式系统传送装置一起使用的隔膜器
CN113143759B (zh) * 2015-07-16 2024-01-30 西部制药服务以色列有限公司 用于安全的伸缩的卡扣配合在注射剂小瓶上的液体药物转移装置
CN113143759A (zh) * 2015-07-16 2021-07-23 西部制药服务以色列有限公司 用于安全的伸缩的卡扣配合在注射剂小瓶上的液体药物转移装置
CN105496644A (zh) * 2016-01-23 2016-04-20 王翠兰 鼓膜穿刺、鼓室内注射医疗装置
CN105496644B (zh) * 2016-01-23 2017-12-29 乐清市风杰电子科技有限公司 鼓膜穿刺、鼓室内注射医疗装置
CN105476750B (zh) * 2016-01-23 2017-12-08 吴和明 鼓膜穿刺、鼓室内注射医疗装置
CN105726206A (zh) * 2016-01-23 2016-07-06 王翠兰 鼓膜穿刺、鼓室内注射医疗装置
CN105596145A (zh) * 2016-01-23 2016-05-25 王翠兰 鼓膜穿刺、鼓室内注射医疗装置
CN105476750A (zh) * 2016-01-23 2016-04-13 王翠兰 鼓膜穿刺、鼓室内注射医疗装置
RU189007U1 (ru) * 2017-03-20 2019-05-06 Федеральное государственное бюджетное образовательное учреждение высшего образования "Юго-Западный государственный университет" (ЮЗГУ) Шприц
US20230026744A1 (en) * 2021-07-20 2023-01-26 Alcon Inc. Infusion cannula
US11877955B2 (en) * 2021-07-20 2024-01-23 Alcon Inc. Infusion cannula

Also Published As

Publication number Publication date
EG11922A (en) 1978-09-30
FR2300578B3 (ja) 1978-11-03
DE2605291A1 (de) 1976-08-26
GB1540881A (en) 1979-02-21
AU1105476A (en) 1977-08-18
ES445178A1 (es) 1977-10-01
BE846896Q (nl) 1977-01-31
JPS51106385A (ja) 1976-09-21
ZA76492B (en) 1977-09-28
FR2300578A1 (fr) 1976-09-10
IT1055234B (it) 1981-12-21
BR7600866A (pt) 1976-09-14
SE7601563L (sv) 1976-08-16
CA1077794A (en) 1980-05-20
GB1540882A (en) 1979-02-21

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