US3895631A - Liquid infusion unit - Google Patents

Liquid infusion unit Download PDF

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Publication number
US3895631A
US3895631A US439137A US43913774A US3895631A US 3895631 A US3895631 A US 3895631A US 439137 A US439137 A US 439137A US 43913774 A US43913774 A US 43913774A US 3895631 A US3895631 A US 3895631A
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United States
Prior art keywords
housing
cartridge
flow
fluid
liquid
Prior art date
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Expired - Lifetime
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US439137A
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English (en)
Inventor
Richard G Buckles
Seymour Hoff
Sharon Kehr
Su Il Yum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
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Alza Corp
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Application filed by Alza Corp filed Critical Alza Corp
Priority to US439137A priority Critical patent/US3895631A/en
Priority to GB2137/75A priority patent/GB1484394A/en
Priority to DK16375*#A priority patent/DK16375A/da
Priority to BE152646A priority patent/BE824703A/xx
Priority to IE131/75A priority patent/IE42702B1/en
Priority to FR7502266A priority patent/FR2272686B1/fr
Priority to ZA00750546A priority patent/ZA75546B/xx
Priority to AR257431A priority patent/AR203226A1/es
Priority to IL46521A priority patent/IL46521A/en
Priority to ES434296A priority patent/ES434296A1/es
Priority to NLAANVRAGE7501132,A priority patent/NL168136C/xx
Priority to AT72975A priority patent/AT355195B/de
Priority to DE19752504048 priority patent/DE2504048A1/de
Priority to SE7501133A priority patent/SE408018B/xx
Priority to AU77819/75A priority patent/AU481623B2/en
Priority to FI750291A priority patent/FI750291A/fi
Priority to NO750318A priority patent/NO135119C/no
Priority to CA219,297A priority patent/CA1063475A/en
Priority to JP1421075A priority patent/JPS5422718B2/ja
Priority to IT67281/75A priority patent/IT1027456B/it
Priority to CH129575A priority patent/CH591248A5/xx
Priority to BR707/75A priority patent/BR7500707A/pt
Application granted granted Critical
Publication of US3895631A publication Critical patent/US3895631A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/152—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags pressurised by contraction of elastic reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/28—Clamping means for squeezing flexible tubes, e.g. roller clamps

Definitions

  • An improved infusion unit for intramuscular, subcutaneous intravascular delivery of liquid drug to a patient includes (a) a compartmented housing carrying a (b) removable, refillable liquid drug cartridge selectively communicating with a (c) fluid passageway in the housing and suitably connected with a (d) catheter.
  • the cartridge contains a distensible bladder or liquid repository leading to an adjustable fluid flow controller disposed in the passageway and which accurately meters the amount of liquid drug dispensed from the bladder to the patient.
  • the unit is completely self-contained and can be conveniently attached to the patient near the point of infusion for ambulatory use.
  • the present invention relates to devices for the storage and dispensing of liquid, and more particularly, to an improved portable apparatus for delivery of precisely controlled amounts of a liquid drug to a patient.
  • the present invention has another object in the construction of an aesthetically pleasing, self-contained infusion unit for the ambulatory delivery of small amounts of liquid drug over a relatively extended period.
  • Another object of this invention is to house a removable fluid supply cartridge, a precise low flow-rate fluid metering assembly, and related indicators in a contiguous, self-contained assemblage.
  • a further object of the present invention is to construct a lightweight, portable infusion unit which is disposable and particularly well suited for ambulatory use.
  • an assembly for the controlled, reproducible flow of a liquid drug from a self-contained supply to a patient includes a sectioned housing; a repository of liquid drug under pressure, removably disposed in a first section of the housing; a flow metering assembly in a second section of the housing; a fluid passage in the housing interconnecting the repository with the flow metering assembly; and a conduit connected with the flow metering assembly for directing metered amounts of the liquid drug exteriorly of the housing to the patient.
  • This invention is particularly advantageous over the prior art in that a supply of liquid drug may be comfortably carried by a patient and applied, by infusion, directly where needed; that an infusion unit providing precisely metered low flow-rates may be simply and economically manufactured by production line techniques; that medical accuracy may be obtained in an ambulatory self-contained assemblage which is unimposing and aesthetically pleasing, and that the unit can be calibrated to administer precise dosages, is simple to operate, and is designed to be disposable after use.
  • FIG. 1 is a perspective view of a preferred embodiment of an intravascular infusion unit according to the present invention
  • FIG. 2 is a top plan view, partially in section, of the infusion unit of FIG. 1;
  • FIG. 3 is a sectional view, partially in elevation, of a portion of the flow control assembly of the infusion unit of FIG. 1;
  • FIG. 4 is an exploded perspective view of the infusion unit of FIG. I with certain parts broken away and certain parts shown in section,
  • FIG. 5 is a bottom plan view of the infusion unit of FIG. 1;
  • FIG. 6 is an exploded perspective view of the fluid repository cartridge of the infusion unit of FIG. 1;
  • FIG. 7 is a sectional view of a detail of the valve assembly of the cartridge of FIG. 6.
  • a preferred embodiment of an infusion unit in accordance with the present invention includes a main housing 10 having a generally rectangular support base 12 upon which are mounted the various subassemblies making up the completed appa ratus.
  • Support base 12 is preferably, slightly curved in order to accommodatingly conform to the curvature of either a particular portion of the torso of a patient or an extremity thereof, such as an arm or leg.
  • the embodiment illustrated herein is particularly well suited for use on the arm or leg of a patient, and in order to maintain the infusion unit in position upon such extremity, any of various suitable attaching mechanisms.
  • assemblies or devices may be employed, such as a pair of adjustable elastic bands 14 and I6 afi'ixed to the underside of the base 12 as shown in FIG. 1. While only support straps have been illustrated herein for the sake of brevity, it should be understood that any appropriate technique may be used to attach the infusion unit of the present invention to the patient.
  • Exemplary devices are synthetic or metallic clips or bracelets; suitable belts or straps provided with cloth fasteners, zippers, buckles or the like; or elastic or inelastic ties or adhesive tapes.
  • Compartment 20 is defined by a generally flat, upright interior wall 22, an outwardly and downwardly angulated floor 24, and a generally flat angularly inclined outer wall 26.
  • the end of compartment 20, to the left as visualized in FIG. 1, is closed by a triangularly shaped wall 28 which is contiguous at its periphery with walls 22, 26 and the support base member l2.
  • the opposite end of compartment 20 is spaced from the right edge of support base 12 and is open to enable communication between compartment 18 and a generally rectangular slot or recess disposed between housings l8 and 20.
  • Compartment I8 has along its inner side a generally upright wall 30, which extends from support base 12 to the upper edge of a flat, inclined outer wall 32 which joins base 12 along its longitudinal edge.
  • the left end of housing or compartment l8, as visualized in FIGS. 1 and 4, is closed by a triangular, upright wall 34, with the opposite end of the compartment l8 open and recessed from the edge of support base 12 in a manner similar to that of housing or compartment 20.
  • a convex wall 36 of generally triangular configuration has a smoothly rounded inwardly directed flange formed about the upper periphery thereof and closes the right end of the assembly by joining walls 26 and 32 with the support base 12.
  • a locking lever 40 is journalled at an end 42 for pivotal rotation about a pin 44 protruding inwardly from upright wall 30 of compartment 18. End 42 further sup ports a flange 46 for cooperative engagement with a protrusion (not shown) on wall 30 so as to delimit the degree of upward swing of arm 40 away from the support base 12.
  • the other end 48 of lever 40 carries a downwardly extending generally flat plate 50.
  • a locking tang 58 protrudes laterally below the bottom edge of plate 50 for cooperative engagement with an aperture 60 (FIG. defined in the support base 12 of the infusion unit 10.
  • Arm 40 also carries a generally triangular, curved outer wall 62 which acts as a handle and is shaped such that the lever 40, when in the closed or locked position, is contiguous at its outer surface boundaries with the outer surfaces of compartment 18 of the infusion unit.
  • the floor 24 of compartment carries a plurality of protrusions which cooperate with the various components of the flow control system of the present invention shown in detail in FIG. 3 and also in FIGS. 2 and 4.
  • a first, generally U-shaped flow passage 70 which terminates at one end in a needle or pin-like protrusion 72 having a hole 74 therethrough communicating with a small, generally cylindrical interior chamber 76.
  • a suitable O-ring 78 Spaced from the front wall of chamber 76 by a suitable O-ring 78 is a filter assembly 80 consisting of one or more filters designed to trap or retain small particles or sediment and bacteria and preclude the passage of the same through the downstream portions of the flow control assembly to be described more fully below.
  • a flow passage 82 Downstream of filter assembly 80 is a flow passage 82 defined by a groove in the outer wall of element 70 and a suitable flat plate 84 attached thereover. Passage 82 continues through an elbow 86 in member 70 and is outwardly divergent to provide a second interior chamber 88.
  • element 70 is constructed so as to join with base 12, the edge of end piece 36, and upstanding walls 22 and 30 at the right ends of compartments l8 and 20. In this manner, member 70 functions as an end wall of the generally rectangular slot or void 90 atop base 12 between chambers 18 and 20 and closes off the compartment joining compartments l8 and 20 of the overall housing.
  • Chamber 88 in elbow 86 has a first outlet port 92 and a second, smaller outlet port 94 disposed side-by-side in a wall 96. Ports 92 and 94 protrude slightly from the outer surface of wall 96 and have attached thereto, in sealed relationship, first and second flexible fluid carrying conduits 98 and 100, respectively.
  • a generally rectangular upstanding block 102 is formed in the floor 24 of compartment 20 and has longitudinally aligned thereupon a pair of upstanding dividing walls 104 and 106. Walls 104 and 106 are spaced from each other such that the slot defined therebetween will accommodate flexible conduit I00, with larger flexible conduit 98 disposed on the other side of wall 106.
  • Connector block 108 is preferably rectangular in configuration, but may be of any suitable external shape as desired. As shown, block 108 has a groove running completely thereabout for firm engagement with a generally U-shaped upstanding protrusion 114 in the floor 24 of compartment 20.
  • a chamber 116 provides communication between ports and 112 and an outlet port 118 for connection through the floor of compartment 20 with a flexible surgical tube 120.
  • the end of tube or conduit I20 is suitably connected with a catheter or needle for intravascular infusion of fluids to a patient in the conventional manner.
  • Disposed interiorly of conduit 98 are a plurality of elongate fibers 122 which coextensively are nested in a close relationship and fill a substantial portion of the cross-sectional volume of the conduit 98.
  • a spring element 124 (FIG. 2) is held at its proximal end in a recess 126 formed adjacent elbow 86 in the floor 24 of compartment 20 and has, at its distal end, an offset, curved portion adapted to engage flexible conduit 100.
  • Spring 124 when disposed in recess 126 exerts a biasing force against the flexible conduit 100 so as to pinch or crimp the same between the curved offset portion thereof and the side of upstanding wall 106. In this manner, spring 124 normally precludes the passage of fluid through conduit 100 and enables fluid flow therethrough only when the spring is lifted away from wall 106.
  • a first generally triangular wedge member 128 is mounted on the opposite side of flexible conduit 98 from wall 106 and is slidable laterally into engagement with such conduit in a path defined by stops 130 and 132 in the floor of compartment 20.
  • a control wedge 134 is disposed adjacent wedge 128 such that longitudinal movement of the control wedge 134 urges wedge 128 into engagement with flexible conduit 98 which is thereafter compressively entrapped between the wedge 128 and upstanding wall 106, the floor of block 102 and the wall 26.
  • Such compressive force distorts the configuration of the conduit 98 such that the area therein decreases resulting in the elongated fibers 122 taking up more of the available space within the conduit for fluid flow.
  • At the left end of control wedge 134 as visualized in FIG.
  • a rack gear 136 is provided having a guide prong 138 protruding from the end thereof so as to slidably engage the front corner of compartment 20.
  • a pointing arm 140 extends from the end of rack gear 136 in a direction opposite to the projection 138 and has a scribed line thereon for cooperation with a flow-rate scale I44 carried upon the outside of wall 26 (FIG. 1). Pointer 140 can be seen through an opening 146 in wall 26 and, since the longitudinal position of rack 136 determines the lateral position of wedge 128, indicates the flow-rate of fluid being dispensed through the infusion unit according to the present invention.
  • a second aperture 148 is defined by the wall 26 of compartment 20 for admitting a first end of a tool 150 having a pinion gear 152 formed thereon for cooperative interengagement with the gear teeth of rack 136.
  • tool 150 may easily be inserted through aperture 148 and rotated so as to longitudinally move the control wedge 134 for regulating the force applied through wedge 128 to the fiber containing conduit 98.
  • the flow-rate thus established is accurately maintained and is precisely indicated by the position of pointer 140 with respect to scale 144.
  • Chamber 116 in connector block 108 defines a hole or opening 158 in the wall thereof opposite ports 110 and 112, which hole is closed by a flexible diaphragm 160 sealed by a suitable annular clamp 162. Diaphragm 160 thus moves in response to the pressure built up within the system located between the flow control element I and the outlet tubing 120.
  • An L-shaped indicator arm 164 is pivotally mounted to the floor 24 of compartment and has a first leg 166 engageable with and responsive to movement of diaphragm 160 of the connector block 108.
  • the other leg 168 of lever 164 carries a flag or signal 170 at its distal end.
  • Signal 170 may be painted with a bright color or provided with any other suitable indicia and has its arcuate path of travel aligned so as to bisect an aperture 172 in wall 26 of compartment 20.
  • a small biasing spring 174 is torsionally wound about the axis of arm 164 between leg 168 and a stop 176 in the floor of compartment 20.
  • arm 164 is gently biased such that leg 166 engages the diaphragm 160, with leg I68 carrying signal 170 to a nested position hidden behind wall 26 away from aperture 172.
  • leg 166 engages the diaphragm 160
  • leg I68 carrying signal 170 to a nested position hidden behind wall 26 away from aperture 172.
  • the pressure of the fluid supply causes diaphragm 160 to bulge outwardly from connector block 108 thereby rotating arm 164 and transposing signal 170 to a position immediately behind aperture 172.
  • the visual perception of signal 170 through aperture 172 thereafter apprises the patient or his attending physician or nurse that infusion has ceased.
  • a plurality of grooves such as orthogonal grooves 180, 182 and 184 are formed in the undersurface of support base 12 in order to allow fluid conduit 120 to be guided along the bottom of base 12 and brought out to the front, rear or side of the infusion unit for ultimate connection to the catheter at the end of the tube in the most convenient manner.
  • any number of grooves may be provided in the undersurface of support base 12 and that the three grooves shown in FIG. 5 are merely exemplary of such structures.
  • a cartridge assembly 200 formed of left and right cartridge halves 202 and 204, respectively, has a generally rectangular overall configuration conforming to the void or slot defined above base 12 between compartments l8 and 20. Further, the upper surfaces of sections 202 and 204 are slightly curved such that when the cartridge is slidably engaged with the support base and housings, and arm 40 is pivotally moved to its locked position, the overall assembly has a smooth contiguous outer surface as shown in FIG. 1.
  • Portion 204 of cartridge 200 has a first end wall 206 defining an aperture 208 therein. Aligned over aperture 208 is a valve assembly 210 of a distensible fluid containing bladder or repository 212.
  • Valve assembly 210 is attached to wall 206 in any suitable manner such as by means of clamps, bolts, interlocking grooves, etc.
  • valve assembly 210 is a flat, resilient member 214 having a pair of frustoconical apertures 215, which, as shown in FIG. 7 in solid lines is urged by the internal pressure within the bladder into a closed position in sealed engagement with wall 206 of the cartridge assembly 200.
  • any suitable valve assembly may be incorporated into the bladder 212 and, in the alternative, valve 210 may be replaced with a simple flap valve or flexible seal adapted to be punctured by a needle for admitting or dispensing fluid. Such modification would be accomplished with like modification of projection 72 or substitution of a sharp needle therefor.
  • microfilter element 220 Aligned over opening 216 against the surface of flange 218 is a microfilter element 220 which allows the passage of air therethrough but not fluid.
  • microfilters may be formed of any well-known, commercially available materials and thus will not be described in detail for the sake of brevity.
  • Element 220 is firmly clamped between flange 218 and the inner flat surface of a sliding element or spider 222 having a plurality of arms 224 extending radially from a central hub thereof. Arms 224 are preferably engaged with the four inner corners of the rectangular shell provided by portions 202 and 204 of cartridge 200 such that the spider is freely slidable longitudinally within the compartment.
  • An aperture 226 extends completely through the central hub of the sliding element 222 such that air passing through filter 220 may be expelled to the atmosphere.
  • a generally L-shaped indicating arm 228 protrudes upwardly from the central hub of member 222 and has a first leg which extends over a recessed path 230 longitudinally disposed along a central portion of portion 204.
  • a suitable volume scale 232 is imprinted upon the upper surface of portion 204 and cooperates with indicator arm 228 to enable easy perception of the volume contents of the bladder or repository 212.
  • bladder 212 may be distended by the admission of fluid under pressure through valve 210 such that the bladder is axially and radially enlarged, as shown in FIG. 2, for storing the liquid under pressure.
  • the liquid drug As the liquid drug is forced into the bladder 212, the same be comes axially elongated such that slider 222 moves toward the end away from the valve 210 indicating a volumetric change by the cooperation of indicating pointer 228 and scale 232.
  • the fluid repository 212 is supported between the valve assembly 210 attached with wall 206 of the compartment or cartridge 200 and the central hub of slider 222, the same is maintained at all times in spaced relationship with the inner walls of the compartment to allow precise delivery of the entire contents of the bladder with minimal frictional interference.
  • the distensible elastic walls of the bladder 212 are constructed of a material having a characteristic enabling distention of the walls to approximately the inner dimensions of the cartridge 200 such that the bladder, even when fully distended, does not engage the inner walls of the cartrid e.
  • a pair of pins 240 and 241, protrude laterally from the ends of a side wall of portion 202 of cartridge 200 for cooperative engagement with the inner edge of plate 50 and flange 46, respectively.
  • pin 241 engages flange 46 and as arm 40 is rotated downwardly, pin 240 slides along said inner edge to firmly urge the cartridge into a nested position with the pin or nozzle end 72 of the housing fluid passage inserted through aperture 208 and into engagement with the member 214 of valve assembly 210.
  • a particular liquid drug intended to be administred by infusion to a patient is first forced into ,the distensible bladder 212 through valve assembly 210.
  • An appropriate fitting may be formed on the valve end of the cartridge 200 for cooperation with a supply capsule such that the liquid drug supply may be affixed to the cartridge 200 with a needle-like member engaging member 214 of the valve assembly to open the same for the admission of fluid.
  • Such fluid under pressure, is then forced into the bladder causing the same to be radially and axially expanded or distended to a capacity of from about cc to 100 cc. While such fluid is being forced into the bladder 212, slider 222 will be moved axially toward the end opposite valve assembly 210, indicating the volumetric capacity of fluid by the relative position of pointer arm 228 with respect to volume scale 232.
  • microfilter 220 allows any air initially contained within the deflated bladder 212 to pass through aperture 226 in the slider 222 for assuring complete filling of the repository with the liquid drug to be dispensed.
  • mocrofilter 220 may be of any suitable type, such as that sold under the name Cellguar and enables the passage of air but yet precludes the flow of the liquid drug out of the repository 212, thereby enabling rapid bleeding of the cartridge assembly so that it will be filled only with the liquid drug.
  • the cartridge may be properly positioned in the void or slot 90 formed by the spaced positioning of compartments 18 and 20 atop support base 12.
  • cartridge assembly 200 is positioned at the left end of the slot 90, with locking arm 40 in approximately the position illustrated in H6. 4.
  • the cartridge is then gently slid to the right, the same being properly guided or aligned between upstanding walls 22 and 30. As shown in FIGS.
  • the projecting pin 72 of end member first passes through aperture 208 in the right wall 206 of the cartridge assembly and, as the cartridge is further advanced, engages member 214 so as to defonningly urge the same to its open position (illustrated in phantom in FIG. 7) thereby permitting liquid to flow through apertures 215 and slots or openings in the leading end of pin 72 (not shown) and thus into hole 74.
  • lever arm 40 must be moved downwardly toward its locking position. This action causes pin 240 to slide along the inner edge of plate 50 further urging the cartridge assembly 200 into its properly nested position atop the support base 12. After the cartridge assembly is fully seated to the right as shown in FIG. 2, locking arm 40 may be further moved such that the locking tang 58 engages the shoulder of rectangular opening 60 in the base 12 and firmly locks the cartridge in place.
  • the housing has a smooth, continuous exterior surface whereby the assembly resembles a unitary structure.
  • the cooperative interaction of pin 72 and member 214 causes the establishment of communication between the liquid drug contents of the repository 212 and the fluid passageway 82 formed in the right end of the housing assembly.
  • Such fluid is then enabled to flow through aperture 74 and into chamber 76 where it must pass through the filter assembly 80 thereby assuring the removal of any bacteria, sediment or other small particles which may have inadvertently entered the system.
  • the filter assembly 80 assures the complete removal of all particles thereby guaranteeing the positive metering of fluid through the fluid flow control to be described below.
  • the fluid passage 82 opens into chamber 88 which feeds both the main flexible conduit 98 and the smaller secondary conduit 100. These two conduits form parallel paths for the flow of fluid through the system with the main branch providing precise arid accuratemetering of fluid during normal operation and the smaller conduit 100 enabling rapid bypass or bleeding of the system during selected times.
  • the controlled flow through the parallel circuit of flexible conduits 98 and 100 passes through connector block 108 from whence it is delivered through tube 120 for intravascular infusion. While the particular details of the entire tube assembly 120 have not been shown, it shouldbe understood that any well-known surgically approved technique may be utilized whereby the tube 120 terminates in an l.V. catheter or needle for insertion into the patient for administration of the drug or in a standard connector for connection to a catheter or needle.
  • a spring member 124 (FIG. 2) has an offset, curved distal and portion which is normally biased into engagement with flexible conduit 100 so as to pinch the same against upstanding wall 106 thereby closing the conduit to the passage of fluid from repository 212. Since the primary flow through conduit 98 is a low-rate flow, it would take considerable time to bleed any air from the system when initially preparing the apparatus for use. Thus, spring member 124 is provided for cooperation with bypass conduit 100 such that as the spring 124 is moved away from the conduit, a secondary flow is enabled through conduit 100 so as to rapidly purge the system of any air. Thereafter, spring 124 may be released whereupon the bypass conduit 100 is again closed-off enabling the fluid flow to again be precisely metered through primary conduit 98. As shown in FlG. 1, a generally rectangular opening may be provided in the wall 26 of compartment to enable a flat blade of tool 150 to be inserted into the compartment 20 for the selective flexure of spring 124 away from conduit 100.
  • Conduit 98 contains a plurality of coextensively disposed elongated fibers 122 which, as shown, substantially fill the conduit and are parallel to each other within the conduit 98.
  • Fibers 122 are essentially linear and are made of a resilient elastomeric material, such as, for example, the poly(urethane) sold under the name Lycra Spandex, silicone rubber, polyisoprene and butyl rubber. Since conduit 98 rests in position atop block 102 between upstanding wall 106 and and a flat side of wedge member 128, a compressive force is applied to the conduit in a direction which is perpendicular to the flow of fluid therethrough. This compressive force is applied to the conduit at the point where the axially aligned fibers 122 are disposed, and may be applied over all or part of the length of the aligned fibers.
  • conduit 98 As a compressive force is applied against conduit 98 by the wedge 128, the conduit is selectively caused to be deformed. Since the circumference of conduit 98 does not change appreciably, this deformation brings about a decrease in the conduits cross-sectional area.
  • the cross-sectional area of the aligned fibers does not change appreciably so that as the conduit 98 is compressed, the proportion of the space within the conduit taken up by the fibers is changed to enable precise metering of fluid flow therethrough.
  • the internally aligned fibers are closely packed within the conduit and generally should take up at least 50 percent of the internal cross-sectional area of the conduit prior to compression.
  • the fibers are themselves of rounded or cicular cross-section such that they align themselves in a close-packed, nested configuration.
  • control wedge 134 is disposed in compartment 20 and coacts with wedge 128 such that the longitudinal position of control wedge 134 causes very slight movements of wedge 128 perpendicular to the conduit. In this manner, compressive forces of greater and lesser magnitude are simply, effectively, and reproducibly generated and applied by wedge 128 to the conduit 98.
  • the control wedge 134 carries a rack gear 136 which, as noted above, is accessible through aperture 148 in the outer wall 26 of compartment 20. Pinion gear 152 of tool 150 may be easily inserted through aperture 148 so as to engage the rack gear 136 whereupon rotation of the tool accurately and precisely positions the control wedge 134.
  • the position of the control wedge 134 is determinative of the compressive force applied to conduit 98, and thus, the flow-rate established from the system, the position of pointer arm 140 relative to scale 144 enables the simple and precise visual perception of the preselected flow-rate of the system.
  • tool may be removed so as to preclude inadvertent adjustment or regulation of the flow-rate setting during use of the system. of course, by subsequent reinsertion of the pinion gear 152 of tool 150 the system flow-rate may be reset as desired.
  • Conduits 98 and 100, fibers 122, and the distensible bladder 212 may be formed of the same material or of different materials. While any number of suitable materials may be utilized, certain exemplary materials are those which are resilient, deformable and are inert to the fluid or liquid drugstored and administered by the system.
  • Exemplary materials include natural rubber (preferably suitably extracted or treated to remove impurities which potentially would contaminate the fluid), as well as synthetic elastomers, for example, poly(isoprene), poly( l,4-butadiene), segmented polyurethane of the poly-ether variety, block coor terpolymers containing butadiene and styrene, silicone rubbers such as the silastics, butyl rubber, nitrilelbutadiene rubber and neoprene.
  • natural rubber preferably suitably extracted or treated to remove impurities which potentially would contaminate the fluid
  • synthetic elastomers for example, poly(isoprene), poly( l,4-butadiene), segmented polyurethane of the poly-ether variety, block coor terpolymers containing butadiene and styrene, silicone rubbers such as the silastics, butyl rubber, nitrilelbutadiene rubber and neopre
  • the present invention is further provided with a flow indicator so as to apprise the user of the cessation of fluid delivery from the system.
  • Diaphragm secured over opening 158 in the connector block 108 responds to the pressure of fluid within the system and causes a proportionate movement of the pivotally mounted arm 164 in accordance with such pressure changes.
  • the fluid pressure within connector block 108 is relatively low such that arm 164 is permitted to be rotated clockwise by spring 174, thereby carrying the signal to a nested position away from aperture 172 in the outer wall of the compartment 20.
  • the present invention is preferably designed to be worn or attached to a portion of the torso or an extremity of a patient and is particularly well suited in connection with the direct administration of liquid drugs which must be applied in very slow rates over an extended period of time directly to a particular site of disease, infection, or the like.
  • liquid drugs which must be applied in very slow rates over an extended period of time directly to a particular site of disease, infection, or the like.
  • the infusion unit can, according to the present invention, be attached to the patient either on the upper arm or forearm with the slight curvature of the lower surface of the support base 12 generally conforming to the curvature of such extremity portion. Straps l4 and 16 may be then adjusted so that the infusion unit is comfortably held in position about the arm of the patient.
  • the surgical tube 120 may then be positioned within one of the orthogonal grooves 180, 182 or 184 along the bottom of base 12 and brought out from that side of the infusion unit closest to the selected point of insertion of the l.V. catheter.
  • tube 120 is of the nonclosure type, that is, its passageway is of a generally triangular cross-section which prevents it from being easily pinched off.
  • a cartridge 200 which has been previously filled with the desired drug to be administered is slid onto the support base 12 in the manner described above.
  • the blade end of tool 150 may be inserted through the opening in the housing wall to lift spring 124 away from bypass tube 100 causing the relatively rapid emission of fluid from the repository 212 through the passageways inside the infusion unit and thence through tube 120 and the catheter so as to discharge all of the air present within the system.
  • Spring 124 is thereafter released closing off the bypass passage and allowing the desired, precisely metered flow-rate to be established by the primary fluid conduit 98 and its contained fibers 122.
  • the catheter is then inserted into the selected tissue or vascular passage associated with the disease site to be treated, and the precise, desired flow-rate is preset by insertion and rotation of tool 150 through opening 148.
  • the positioning of control wedge 134 is thus easily selected and may be observed by comparison of pointer 140 with scale 144.
  • the device will then continuously administer the precisely metered low flow-rate of liquid drug to the patient.
  • the infusion unit according to this invention is preferably constructed of molded plastic so as to be extremely lightweight and economical to fabricate. Such molding may be accomplished in accordance with any well-known techniques and, as such, may be fabricated from a number of individually molded pieces conventionally attached to form the overall apparatus. In this manner, the entire assembly may be sufficiently economically manufactured so as to be disposable after a single or a predetermined limited number of uses.
  • the present invention provides a number of material advantages over devices heretofore available and allows precisely reproducible metered flow-rates of liquid drugs to be administered to a patient by infusion by apparatus which is economical, simple, aesthetically pleasing, and allows the patient to be at all times ambulatory while undergoing treatment.
  • the infusion unit according to the present invention may easily accommodate any number of replaceable cartridges containing the same or different liquid drugs for administration to a patient at various times, each cartridge being refillable or disposable after such patient has completed the intended treatment.
  • a liquid storing and dispensing assembly comprising:
  • flow control means in said housing between said inlet and outlet means for precisely controlling liquid flow through said passage
  • a cartridge removably engaged with said housing the exterior of said cartridge cooperating with the exterior of said main housing such that the assemblage has a contiguous exterior surface, said cartridge including a repository for a quantity of liquid to be dispensed;
  • said inlet means cooperating with said cartridge to establish communication between said repository and said passage when said cartridge in engaged with said housing.
  • said flow control means comprises: a deformable tube, a plurality of parallel, linear elongate fibers coextensively disposed in said tube, and compressing means disposed about the tube and deforming, to variable degrees, the tube.
  • said cartridge comprises an elongated generally rectangular shell, one elongated wall of which is convex and forms a part of said upper surface of said housing.
  • said cartridge includes valve means at one end thereof connected with said repository for enabling delivery of fluid to the exterior of said cartridge, said valve means being normally closed, and wherein said inlet means cooperates with said valve means to open the same when said cartridge is engaged with said housing.
  • a fluid storage and dispensing assembly comprising, in combination:
  • first and second hollow, elongated housing assemblies on said support base in spaced relationship with each other;
  • fluid flow control means in said first housing assembly for controlling the rate of discharge of fluid from said bladder through said passage to said outlet means.
  • Apparatus as recited in claim 6 further including flow indicator means in said first housing assembly, said indicator responsive to fluid flow downstream of said flow control means and having a first state when fluid is being dispensed and a second state when fluid flow ceases.
  • said flow indicator means comprises: a chamber connected in said flow passage between said fluid control means and said outlet means, said chamber defining an opening in a wall thereof; a diaphragm sealed over said opening; and signal means responsive to flexure of said diaphragm to indicate the flow state of fluid in said passage.
  • said signal means comprises an L-shaped lever pivotally mounted at the elbow thereof in said first housing assembly, and means biasing a first arm of said lever into engagement with said diaphragm.
  • Apparatus for metered flow of fluid from a selfcontained supply comprising:
  • flow metering means in said passage for accurately maintaining an established rate of fluid flow from said repository to said outlet means, said flow metering means including control means contained within said housing for receiving a tool for adjusting the rate of fluid flow through said metering means;
  • said housing defining an opening in a wall thereof to allow insertion of said tool into operative engagement with said control means so as to enable adjustment of said metering means said opening being of such size as to allow a patient to adjust said metering means with said tool but not otherwise.
  • said flow metering means comprises: a flexible tube, a mass disposed within said tube and filling a portion of the space defined therein, and means about said tube to apply a compressive force thereagainst.
  • Apparatus as recited in claim 12 wherein said force applying means includes a force applying wedge mounted in said housing for movement towards and away from said flexible tube; and wherein said control means includes a control wedge cooperating with said force applying wedge and movable in a direction generally parallel to the axial direction of said tube.
  • control wedge further carries a pointing arm; and wherein a flow rate scale is imprinted on said housing, said pointing arm cooperating with said flow rate scale to indicate the fluid flow rate established by said control means.
  • said flow metering means further comprises: a by-pass tube connected in said flow passage in parallel with said flexible tube, means closing said by-pass tube to the flow of fluid therethrough, said means being movable to an open position by a second tool inserted through a second opening in the wall of said housing; said by-pass tube having a flow rate capacity greater than said flexible tube whereby rapid bleeding of air from the apparatus may be accomplished and by which rapid dispensing of liquid may be effected.
  • a fluid storage and dispensing assembly comprising; in combination:
  • a hollow housing defining inlet and outlet port means and containing a liquid flow passageway extending between said inlet and outlet port means, said passageway including flow control means for precisely metering fluid flow therethrough;
  • fluid dispensing means connected to said outlet port means for dispensing fluid exteriorly of the assemy;
  • a cartridge removably engaged with said housing and containing a fluid repository, said cartridge having connector means for cooperative engagement with said inlet port means of said housing to enable fluid contained within said repository to be dispensed through said passageway;
  • said housing including guide means for aligning said connector means of said cartridge with said inlet port means for interconnection thereof;
  • said cartridge holding means comprising a pin protruding from a wall of said cartridge and a locking bar pivotally attached to said housing, said locking bar defining a surface adapted to slidably engage said pin for urging said cartridge into a locked position on the housing as the locking bar is pivotally moved and for holding said cartridge securely in place.
  • a device for the continuous delivery of a controlled reproducible flow of liquid comprising, in combination:
  • a housing defining inlet and outlet port means and containing a liquid flow passageway extending between said inlet and outlet port means, said passageway including flow control means for precisely metering flow therethrough;
  • a cartridge removably engaged with said housing and comprising,
  • support means has a pointing arm and wherein said shell has a volume scale imprinted thereon, said pointing arm and said scale cooperating to indicate the voltune of fluid contained within said bladder.
  • a device for the continuous delivery of a controlled reproducible flow of a liquid drug to a patient comprising, in combination:
  • a main housing adapted to be carried by the patient
  • a cartridge removably engaged with said housing the exterior of said cartridge cooperating with the exterior of said housing to form an assemblage having a contiguous exterior surface, said cartridge includ ing a repository for a quantity of the liquid drug under pressure;
  • said inlet means cooperating with said cartridge to establish communication between said repository and said passage when said cartridge is engaged with said housing;
  • main housing has an exterior wall generally conforming to the curvature of an extremity of the patient and includes means for attaching the housing to such extremity.
  • liquid drug is a drug for intravascular, subcutaneous or intramuscular infusion
  • means for administering the drug to a patient comprises means for such infusion
  • An infusion unit for the continuous delivery of a controlled reproducible flow of a liquid drug to a patient, comprising, in combination: a housing defining inlet and outlet port means and containing a liquid flow passageway extending between said inlet and outlet port means, said passageway including flow control means for precisely metering fluid flow therethrough, and a liquid drug supply cartridge removably engaged with said housing at said inlet port means and comprismg:
  • radial support means disposed in said shell and slidably engaged with the interior walls of said shell, and an expandable bladder of generally cylindrical geometry supported at each end between the opening in said shell and said support means whereby said bladder may be distended with a quantity of liquid drug and subsequently deflated with minimal frictional contact with interior walls of said shell, said support means sliding axially within said shell to accommodate variations in the axial dimension of said bladder; and means connected with said outlet port means for infusion of the metered amounts of liquid drug from said cartridge to the patient.
  • a liquid drug supply cartridge for use in an assembly for the continuous delivery of a controlled reproducible flow of such liquid drug to a patient, having a housing defining inlet and outlet port means and containing a liquid flow passageway extending between said inlet and outlet port means, said passageway including flow control means for precisely metering fluid flow therethrough, means connected with said outlet port means for administering the liquid drug to the patient, said cartridge removably engageable with said housing at said inlet port means and comprising:
  • radial support means disposed in said shell and slidably engaged with the interior walls of said shell, and an expandable bladder of generally cylindrical geometry supported at each end between the opening in said shell and said support means whereby said bladder may be distended with a quantity of liquid drug and subsequently deflated with minimal frictional contact with interior walls of said shell to disWOOD such drug, said support means sliding axially within said shell to accommodate variations in the axial dimension of said bladder.
  • An infusion unit for the continuous delivery of a controlled reproducible flow of a liquid drug to a patient comprising, in combination:
  • a main housing adapted to be carried by the patient
  • said flow control means in said housing between said inlet and outlet means for precisely and reproducibly regulating and permitting to pass small controlled amounts of liquid through said passage, said flow control means including (a) a deformable tube, (b) a plurality of parallel, linear elongate fibers coextensively disposed in said tube, and (c) compressing means disposed about the tube and defonning, to variable degrees, the tube;
  • cartridge removably engaged with said housing to form an assemblage having a contiguous exterior surface
  • said cartridge including a repository for a quantity of the liquid drug under pressure and comprising (a) an elongated, hollow shell having an opening at one end selectively cooperating with said inlet means for the transfer of liquid drug to said passage, (b) support means slidably disposed in said shell, and (c) an expandible bladder of generally cylindrical geometry supported at each end between the opening in said shell and said support said inlet means cooperating with said cartridge to establish communication between said bladder and said passage when said cartridge is engaged with said housing; and

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US439137A 1974-02-04 1974-02-04 Liquid infusion unit Expired - Lifetime US3895631A (en)

Priority Applications (22)

Application Number Priority Date Filing Date Title
US439137A US3895631A (en) 1974-02-04 1974-02-04 Liquid infusion unit
GB2137/75A GB1484394A (en) 1974-02-04 1975-01-17 Liquid infusion unit
DK16375*#A DK16375A (ko) 1974-02-04 1975-01-21
BE152646A BE824703A (fr) 1974-02-04 1975-01-23 Dispositif d'administration de liquides par infusion
IE131/75A IE42702B1 (en) 1974-02-04 1975-01-23 Liquid infusion unit
FR7502266A FR2272686B1 (ko) 1974-02-04 1975-01-24
ZA00750546A ZA75546B (en) 1974-02-04 1975-01-27 Liquid infusion unit
AR257431A AR203226A1 (es) 1974-02-04 1975-01-27 Dispositivo para la adminstracion endovenosa continua y controlada de medicamentos liquidos a un paciente
IL46521A IL46521A (en) 1974-02-04 1975-01-28 Unit for infusion of liquid drug to the patient continuously and in a controlled dose
NLAANVRAGE7501132,A NL168136C (nl) 1974-02-04 1975-01-30 Infusie-eenheid.
ES434296A ES434296A1 (es) 1974-02-04 1975-01-30 Unidad de administracion de liquidos para administrar de manera continua un medicamento liquido a un paciente.
DE19752504048 DE2504048A1 (de) 1974-02-04 1975-01-31 Infusionsgeraet
AT72975A AT355195B (de) 1974-02-04 1975-01-31 Infusionsgeraet
AU77819/75A AU481623B2 (en) 1974-02-04 1975-02-03 Liquid infusion unit
FI750291A FI750291A (ko) 1974-02-04 1975-02-03
NO750318A NO135119C (ko) 1974-02-04 1975-02-03
CA219,297A CA1063475A (en) 1974-02-04 1975-02-03 Liquid infusion unit
SE7501133A SE408018B (sv) 1974-02-04 1975-02-03 Vetskeinfusionsanordning for kontinuerlig infusion
JP1421075A JPS5422718B2 (ko) 1974-02-04 1975-02-03
IT67281/75A IT1027456B (it) 1974-02-04 1975-02-04 Unita per invusione di liquidi particolarmente per fleboclisi
CH129575A CH591248A5 (ko) 1974-02-04 1975-02-04
BR707/75A BR7500707A (pt) 1974-02-04 1975-02-04 Aperfeicoamento em unidade infusora de liquidos

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US439137A US3895631A (en) 1974-02-04 1974-02-04 Liquid infusion unit

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US57684475A Continuation-In-Part 1975-05-12 1975-05-12

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US3895631A true US3895631A (en) 1975-07-22

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US439137A Expired - Lifetime US3895631A (en) 1974-02-04 1974-02-04 Liquid infusion unit

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US (1) US3895631A (ko)
JP (1) JPS5422718B2 (ko)
AR (1) AR203226A1 (ko)
AT (1) AT355195B (ko)
BE (1) BE824703A (ko)
BR (1) BR7500707A (ko)
CA (1) CA1063475A (ko)
CH (1) CH591248A5 (ko)
DE (1) DE2504048A1 (ko)
DK (1) DK16375A (ko)
ES (1) ES434296A1 (ko)
FI (1) FI750291A (ko)
FR (1) FR2272686B1 (ko)
GB (1) GB1484394A (ko)
IE (1) IE42702B1 (ko)
IL (1) IL46521A (ko)
IT (1) IT1027456B (ko)
NL (1) NL168136C (ko)
NO (1) NO135119C (ko)
SE (1) SE408018B (ko)
ZA (1) ZA75546B (ko)

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Also Published As

Publication number Publication date
NL168136B (nl) 1981-10-16
SE408018B (sv) 1979-05-14
IL46521A0 (en) 1975-04-25
NL168136C (nl) 1982-03-16
GB1484394A (en) 1977-09-01
NO135119C (ko) 1977-02-16
ES434296A1 (es) 1976-12-16
FI750291A (ko) 1975-08-05
IL46521A (en) 1977-11-30
BR7500707A (pt) 1975-11-11
JPS50108790A (ko) 1975-08-27
CA1063475A (en) 1979-10-02
ATA72975A (de) 1979-07-15
IE42702L (en) 1975-08-04
FR2272686B1 (ko) 1982-02-12
SE7501133L (ko) 1975-08-05
ZA75546B (en) 1976-01-28
CH591248A5 (ko) 1977-09-15
NO135119B (ko) 1976-11-08
AU7781975A (en) 1976-08-05
NL7501132A (nl) 1975-08-06
IT1027456B (it) 1978-11-20
DE2504048A1 (de) 1975-08-07
FR2272686A1 (ko) 1975-12-26
AR203226A1 (es) 1975-08-22
IE42702B1 (en) 1980-10-08
DE2504048B2 (ko) 1979-05-23
AT355195B (de) 1980-02-25
JPS5422718B2 (ko) 1979-08-08
NO750318L (ko) 1975-09-01
DK16375A (ko) 1975-09-22
BE824703A (fr) 1975-05-15

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