US3864248A - Pressure modulator for an artificial blood circuit - Google Patents

Pressure modulator for an artificial blood circuit Download PDF

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Publication number
US3864248A
US3864248A US243658A US24365872A US3864248A US 3864248 A US3864248 A US 3864248A US 243658 A US243658 A US 243658A US 24365872 A US24365872 A US 24365872A US 3864248 A US3864248 A US 3864248A
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Prior art keywords
blood
plates
chamber
pressure
pair
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US243658A
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English (en)
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Alain Granger
Jean Lissot
Andre Sausse
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Rhone Poulenc SA
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Rhone Poulenc SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
    • A61M60/89—Valves
    • A61M60/894—Passive valves, i.e. valves actuated by the blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/26—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving
    • A61M1/267—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes and internal elements which are moving used for pumping
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
    • A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
    • A61M60/113—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/247—Positive displacement blood pumps
    • A61M60/253—Positive displacement blood pumps including a displacement member directly acting on the blood
    • A61M60/268—Positive displacement blood pumps including a displacement member directly acting on the blood the displacement member being flexible, e.g. membranes, diaphragms or bladders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
    • A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
    • A61M60/37—Haemodialysis, haemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
    • A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
    • A61M60/38—Blood oxygenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A61M60/424—Details relating to driving for positive displacement blood pumps
    • A61M60/427—Details relating to driving for positive displacement blood pumps the force acting on the blood contacting member being hydraulic or pneumatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control
    • A61M60/508—Electronic control means, e.g. for feedback regulation
    • A61M60/562—Electronic control means, e.g. for feedback regulation for making blood flow pulsatile in blood pumps that do not intrinsically create pulsatile flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/845—Constructional details other than related to driving of extracorporeal blood pumps
    • A61M60/851—Valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/16—Rotary, reciprocated or vibrated modules
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/025—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms two or more plate-like pumping members in parallel
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/06—Pumps having fluid drive
    • F04B43/073—Pumps having fluid drive the actuating fluid being controlled by at least one valve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3639—Blood pressure control, pressure transducers specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control

Definitions

  • a pressure modulator for an artificial blood circuit including at least one readily deformable wall forming [30] Forelg" Apphcamn Pnomy Data a blood chamber having inlet and outlet ducts and a Apr. 13, l97l France 71.12959 pair of substantially rigid plates arranged one on either side of said blood chamber, pulsation chambers dis- Cl posed on the sides of said rigid plates remote from the /321, 210/356 blood chamber and a fluid pulse generator connected [51] Int.
  • SHEET 1 [IF 2 PRESSURE MODULATOR FOR AN ARTIFICIAL BLOOD CIRCUIT
  • the subject of the present invention is a pressure modulator for an artificial blood circuit.
  • artificial blood circuit there is meant a blood circuit outside the body, the two ends of which are connected to a patient, or a circuit of blood or natural or artificial serum feeding a chamber for the culture or preservation of living cells.
  • a pressure modulator for an artificial blood circuit comprising at least one readily deformable wall forming a blood chamber, having an inlet duct and an outlet duct, a pair of substantially rigid plates arranged one on either side of said blood chamber, and forming part of a rigid plate exchanger, at least one pulsation chamber disposed on the side of at least one of said plates remote from said blood chamber; and fluid pulse producing means connected to said pulsation chamber or chambers, to cause slight flexing of the plates and thereby pulsing of liquid in the blood chamher.
  • the modulator according to the invention allows pulsations of any nature to be imposed on this circuit, and in particular to reproduce in it, with great accuracy, the wave of natural pulsation.
  • the plates of the haemodialysers are usually constructed from substantially rigid materials such as polystyrene, and the pressure of the blood between the plates tends to separate them by a very small, but not negligible, amount. This separation is variable and is the greater the more the point considered is separated from the zone of action of the mechanical clamping frame, and so an unequal distribution of the blood flow in the dialyser is introduced.
  • the construction of the present invention applies pressure pulses on the exterior of the plate so that the plates transmit the variations in pressure produced by the pulse producing means to the blood.
  • the pulsation chamber may be provided with a rigid external wall or may be a flexible pouch and can be inflated by liquid (for example, water), especially if the dialyser is used in an inclined position. It can be inflated by gas (for example, air or C0,) and this simplities the connection to a gas pressure pulse generator.
  • liquid for example, water
  • gas for example, air or C0
  • the pulse generator can be of any known type. It can be a piston which compresses the gas in a hermetic chamber connected to the pulsation chamber or chambers, according to the modulations imposed by a cam. It can be an assembly of electromagnetic valves (compressed gas, purging) combined with contact pressure gages by a programmer or by a cardiac rhythm detector. These examples are obviously given without implying any limitation.
  • FIG. 1 is a schematic view of one embodiment of circuit according to the invention.
  • FIG. 2 is an enlarged cross-section through the exchanger of the circuit of FIG. 1 during the pressure applying stage;
  • FIG. 3 is a view similar to FIG. 2 during the nonpressure applying stage.
  • FIG. 4 is a schematic cross-section through a modified form of the exchanger.
  • FIG. 1 there is illustrated a pump 1 arranged to feed blood to a rigid plate exchanger 2 in the form of a dialyser or diaphragm oxygenator and thence, via an arterial inlet 12 to an organ, for example, a kidney 3.
  • a venous outlet 13 from the kidney is connected back to the inlet of the pump 1.
  • a pressure gauge 4 is connected in parallel across the exchanger 2 and controls the flow rate of the pump 1 to provide a predetermined mean pressure in the arterial inlet 12. The pressure gauge also allows the form of the pressure wave of the perfusion liquid to be recorded.
  • pulsation chambers 20 On either side of the exchanger 2 are arranged pulsation chambers 20 and these are connected by means of a duct 14 to a source of fluid, in particular air, under controlled pressure, for example 200 mm mercury above atmospheric pressure and to a vacuum source or atmosphere 6.
  • the connection of these sources to the pulsation chambers is effected by means of a three way electromagnetic valve 10 which can be controlled by contact pressure gages 7 and 8; the contact pressure gage 7 senses a predetermined maximum pressure at which the valve is changed from connecting source 5 to connecting source 6 to the pulsation chambers.
  • Contact 8 is a minimum pressure contact which switches valve 10 from connection to source 6 to connection of source 5.
  • Variable fluid resistances 9 and 11 are provided between sources 5 and 6 respectively and valve 10.
  • the above described apparatus was used to perfuse blood into a pigs kidney.
  • Pump 1 was controlled to maintain an average pressure of mm of mercury in the arterial inlet.
  • the pressure of the blood separates the support plates 2b (FIG. 2) of the exchanger, the volume of the blood in the blood chamber 2c increases as is shown in FIG. 2.
  • the contact 8 or an electrical signal given by pressure gauge 4 reverses the direction of the valve and connects the chambers 2a to the pressure source 5.
  • the pressure introduced in the pulsation chambers causes the support plates 2b to come closer as shown in FIG.
  • the pump 1 acting as a non-return valve.
  • the contact 7 or the signal from gauge 4 reverses the system again.
  • the wave form produced can be varied by throttling to a greater or lesser extent the admission and the escape of the gases through the resistances 9 and 11 or by modifying the volume of the pulsation chambers. in particular, it is possible to produce a blood pressure curve which is very close to the physiological curve at a peripheral artery, and which comprises, like the physiological curve, a systolic peak followed by a diastolic decrease.
  • This arrangement has allowed a living isolated kidney to be kept for 15 hours in an organ preservation circuit also equipped with an artificial lung and a thermostat. Working in the same circuit, but without pulsations, it is not possible to preserve the kidney for more than 7 hours.
  • FIG. 4 illustrates a modified form of exchanger used for the haemodialysis of a patient and having the same system of pneumatic movement as in FIG. 1 and which can, for example, be connected to a patient by means of an arterio-venous short circuit or a fistula.
  • the blood pump 1 is unnecessary since non-return valves 15 and 16, such as butterfly valves or ball valves are included in the inlet or outlet ducts l7 and 18 of the exchanger 2.
  • a pulse frequency of 60 beats per minute allowed a flow rate of 200 em /minute, that is to say 3.3 cm per pulse, to be provided.
  • a pressure modulator for an artificial blood circuit comprising, in combination:
  • At least one pulsation chamber disposed on the side of at least one of said plates remote from said blood chamber;
  • a fluid pulse generator connected to said at least one pulsation chamber, effective to cause slight flexing of said substantially rigid plates and thereby pulsing of liquid in said blood chamber, according to a time/pressure curve which is very close to the physiological curve at a peripheral artery.
  • a. a plurality of substantially rigid pairs of plates stacked in overlying relation to one another, each of said plates being substantially rectangular and symmetrical, and comprising a front face and a back face, with the front faces of a pair of plates being in facing relation;
  • c. means defining a first exchange zone between each membrane and its adjacent plate
  • d. means defining a blood exchange zone between the two membranes of a pair
  • e. means to feed a first liquid to and from the first exchange zone
  • At least one flexible wall chamber exerting a uniform controlled pressure on at least a portion of said plates, said flexible wall chamber defining a pulsation chamber;
  • said method comprising varying the pressure of the said at least one flexible wall chamber according to a time/blood pressure curve which is very close to the physiological curve at the level of a peripheral artery.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • External Artificial Organs (AREA)
US243658A 1971-04-13 1972-04-13 Pressure modulator for an artificial blood circuit Expired - Lifetime US3864248A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7112959A FR2131144A5 (pl) 1971-04-13 1971-04-13

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US3864248A true US3864248A (en) 1975-02-04

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US (1) US3864248A (pl)
BE (1) BE782009A (pl)
BR (1) BR7202129D0 (pl)
DE (1) DE2217915A1 (pl)
FR (1) FR2131144A5 (pl)
GB (1) GB1378701A (pl)
IT (1) IT951342B (pl)
LU (1) LU65153A1 (pl)
NL (1) NL7204542A (pl)
SE (1) SE7204740L (pl)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4071444A (en) * 1976-10-12 1978-01-31 Purdue Research Foundation Portable chemical reactor for use as an artificial kidney
US4075091A (en) * 1972-06-28 1978-02-21 National Research Development Corporation Method for effecting heat or mass transfer
US4222869A (en) * 1977-05-31 1980-09-16 Isamu Kato Dialyzing method of blood in artificial kidney
US4303068A (en) * 1978-02-28 1981-12-01 Rensselaer Polythechnic Institute Method and apparatus for single pass hemodialysis with high flux membranes and controlled ultrafiltration
US4357239A (en) * 1978-11-22 1982-11-02 Bellhouse Brian John Transfer membrane apparatus
US4361484A (en) * 1979-06-11 1982-11-30 Gambro Ab Process for treating and/or removal of substances from liquid, especially whole blood
US4383921A (en) * 1979-11-21 1983-05-17 Bellhouse Brian John Apparatus for heat or mass transfer
US4565626A (en) * 1983-11-30 1986-01-21 Takeda Chemical Industries, Ltd. Apparatus for blood treatment by pressing blood into treating material and then drawing it out
US4624784A (en) * 1980-09-03 1986-11-25 Memtec Limited Apparatus including a flow path formed by membrane compression
US4762794A (en) * 1983-05-13 1988-08-09 Stephan Nees Apparatus for contacting biological cell systems with a perfusion fluid
US5537335A (en) * 1993-11-01 1996-07-16 University Of Pittsburgh Of The Commonwealth System Of Higher Education Fluid delivery apparatus and associated method
US20030014003A1 (en) * 2001-06-20 2003-01-16 The Regents Of The University Of California Hemodialysis system and method
US20140150991A1 (en) * 2011-05-20 2014-06-05 Equitec Holding B.V. Method for exchanging heat between a heat exchange fluid and a perishable product fluid, a removable heat exchange cartridge and a heat exchange system

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2287241A2 (fr) * 1974-10-09 1976-05-07 Rhone Poulenc Ind Circuit sanguin extracorporel
JPS5544619B2 (pl) * 1974-12-23 1980-11-13
ZA796243B (en) * 1978-11-22 1980-11-26 B Bellhouse Transfer membrane apparatus
ES2232409T3 (es) 2000-04-28 2005-06-01 Ministero Dell' Universita' E Della Ricerca Scientifica E Tecnologica Dispositivo de asistencia ventricular.
CN111840780B (zh) * 2020-06-24 2022-07-12 安徽通灵仿生科技有限公司 适用于ecmo期间血液净化装置的管路适配器

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3060934A (en) * 1960-03-24 1962-10-30 Claff Clarence Lloyd Membrane-type oxygenator
US3412865A (en) * 1964-11-16 1968-11-26 John F. Lontz Artificial kidney
US3631986A (en) * 1968-12-16 1972-01-04 Rhone Poulenc Sa Dialyzer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3060934A (en) * 1960-03-24 1962-10-30 Claff Clarence Lloyd Membrane-type oxygenator
US3412865A (en) * 1964-11-16 1968-11-26 John F. Lontz Artificial kidney
US3631986A (en) * 1968-12-16 1972-01-04 Rhone Poulenc Sa Dialyzer

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4075091A (en) * 1972-06-28 1978-02-21 National Research Development Corporation Method for effecting heat or mass transfer
DE2746291A1 (de) * 1976-10-12 1978-07-13 Purdue Research Foundation Portables chemisches reaktionsgefaess zur verwendung als kuenstliche niere
US4071444A (en) * 1976-10-12 1978-01-31 Purdue Research Foundation Portable chemical reactor for use as an artificial kidney
US4222869A (en) * 1977-05-31 1980-09-16 Isamu Kato Dialyzing method of blood in artificial kidney
US4303068A (en) * 1978-02-28 1981-12-01 Rensselaer Polythechnic Institute Method and apparatus for single pass hemodialysis with high flux membranes and controlled ultrafiltration
US4357239A (en) * 1978-11-22 1982-11-02 Bellhouse Brian John Transfer membrane apparatus
US4361484A (en) * 1979-06-11 1982-11-30 Gambro Ab Process for treating and/or removal of substances from liquid, especially whole blood
US4383921A (en) * 1979-11-21 1983-05-17 Bellhouse Brian John Apparatus for heat or mass transfer
US4624784A (en) * 1980-09-03 1986-11-25 Memtec Limited Apparatus including a flow path formed by membrane compression
US4762794A (en) * 1983-05-13 1988-08-09 Stephan Nees Apparatus for contacting biological cell systems with a perfusion fluid
US4565626A (en) * 1983-11-30 1986-01-21 Takeda Chemical Industries, Ltd. Apparatus for blood treatment by pressing blood into treating material and then drawing it out
US5537335A (en) * 1993-11-01 1996-07-16 University Of Pittsburgh Of The Commonwealth System Of Higher Education Fluid delivery apparatus and associated method
US20030014003A1 (en) * 2001-06-20 2003-01-16 The Regents Of The University Of California Hemodialysis system and method
US20060224100A1 (en) * 2001-06-20 2006-10-05 Michael Gertner Hemodialysis access with on-off functionality
US7144381B2 (en) 2001-06-20 2006-12-05 The Regents Of The University Of California Hemodialysis system and method
US7588551B2 (en) 2001-06-20 2009-09-15 Michael Gertner Hemodialysis access with on-off functionality
US7762980B2 (en) 2001-06-20 2010-07-27 Michael Gertner Hemodialysis access with on-off functionality
US20140150991A1 (en) * 2011-05-20 2014-06-05 Equitec Holding B.V. Method for exchanging heat between a heat exchange fluid and a perishable product fluid, a removable heat exchange cartridge and a heat exchange system
US10045657B2 (en) * 2011-05-20 2018-08-14 Equitec Holding B.V. Replaceable heat exchange cartridge employed in a heat exchange system for temperature control of a perishable fluid

Also Published As

Publication number Publication date
NL7204542A (pl) 1972-10-17
FR2131144A5 (pl) 1972-11-10
BE782009A (fr) 1972-10-13
BR7202129D0 (pt) 1973-06-14
IT951342B (it) 1973-06-30
SE7204740L (pl) 1972-10-16
GB1378701A (en) 1974-12-27
LU65153A1 (pl) 1972-12-07
DE2217915A1 (de) 1972-10-19

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