US3820698A - Device for spraying liquid pharmaceuticals - Google Patents

Device for spraying liquid pharmaceuticals Download PDF

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Publication number
US3820698A
US3820698A US00283511A US28351172A US3820698A US 3820698 A US3820698 A US 3820698A US 00283511 A US00283511 A US 00283511A US 28351172 A US28351172 A US 28351172A US 3820698 A US3820698 A US 3820698A
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US
United States
Prior art keywords
adapter
wall
valve
metering pump
pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00283511A
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English (en)
Inventor
H Franz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Boehringer Ingelheim GmbH
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Application granted granted Critical
Publication of US3820698A publication Critical patent/US3820698A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B12/00—Arrangements for controlling delivery; Arrangements for controlling the spray area
    • B05B12/16—Arrangements for controlling delivery; Arrangements for controlling the spray area for controlling the spray area
    • B05B12/32—Shielding elements, i.e. elements preventing overspray from reaching areas other than the object to be sprayed
    • B05B12/36—Side shields, i.e. shields extending in a direction substantially parallel to the spray jet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
    • B05B11/0005—Components or details

Definitions

  • ABSTRACT A device for mechanically spraying dosage units of liquid pharmaceutical compositions or solutions thereof onto the skin or into body cavities comprises a manually operated valve of a dosage metering pump and an adapter containing a nozzle.
  • Another device used for the mechanical spraying of liquid pharmaceutical compositions was the elastic container, or squeeze bottle, having a spray cap attached thereto.
  • These devices also have the disadvantage that the dosage discharged is not readily controlla ble. The dosage discharged is dependent upon the mechanical pressure exerted upon the elastic container and upon the amount of the contents remaining in the container.
  • a further disadvantage is that many of the active ingredients and solvents would react chemically with the elastic container material, for example with plastics, such as Lupolen; or they would infuse into this container material.
  • aerosol can which comprises a pressurized container which was supplied with a propellant and provided with a pressure valve.
  • a pressurized container which was supplied with a propellant and provided with a pressure valve.
  • the liquid pharmaceutical compositions were not always compatible with the liquid propellant.
  • Spraying of the aerosol composition onto the skin, especially onto the mucous membranes, was known to sometimes create an undesirable cooling effect. If instead of using liquid propellants, compressed gases such as nitrogen or carbon dioxide were used as propellants, then the use of pressure metering valves was not possible. With aerosols it was not possible to meter out a dosage unit of the fluid to be sprayed, because of a loss of pressure occurring after repeated spraying. Often an incomplete evacuation of the container would be the result of inexpert application.
  • It is another object of the present invention to provide a device for spraying liquid pharmaceutical compositions comprising a valve of a dosage metering pump and an adapter connected thereto in a pressure tight manner.
  • the device according to the invention has none of the above mentioned disadvantages. Particularly, there is no need to use containers resistant to compression and no need to use special packing machines and filling devices.
  • the choice of the container material is optional; and inexpensive glass containers may be used which possess the additional advantage that chemical interactions with the liquid charge to be sprayed are practically avoided.
  • the usual safety devices which are necessary when using pressurized containers may also be omitted.
  • the device according to the invention consists of an adapter and a valve of a dosage metering pump which is of known construction.
  • the adapter is sealed in a pressure tight manner onto the valve of the dosage metering pump, and the adapter has a channel containing the fluid pumped up from the valve metering chamber.
  • the channel ends in a spray-nozzle.
  • a vortex spraynozzle is preferably used.
  • the channel of the adapter is fastened to the stem of the valve of the dosage metering pump in a pressure tight manner.
  • the opening of the channel is coaxially aligned with the opening of the stern.
  • the stem moves within the valve metering chamber of the dosage metering pump in the same direction.
  • This movement by the stem under the exerted pressure forces a dosage unit of the liquid outwardly through the channel so as to pass through the spray nozzle.
  • the adapter returns to its starting position, for example, by a counter-acting force produced in the valve of the dosage metering pump, which returning causes a new charge of liquid to flow into the metering chamber.
  • an elastic member such as a spring
  • the spring is placed between the adapter and the valve of the dosage metering pump.
  • the use of the spring is optional.
  • the particular embodiment of the adapter utilized is variable according to the shape of the body cavities into which the pharmaceutical composition is to be sprayed.
  • FIG. 1 is a cross-section view of a valve of a dosage metering pump in combination with an adapter according to the invention.
  • FIG. 2 is a cross-section view of an adapter for spraying into the eye.
  • FIG. 3 is a cross-section view of an adapter f0 spraying into the external canal of the ear.
  • FIG. 4a is a cross-section view of an adapter for spraying the oral and throat cavity.
  • FIG. 4b is a top view of the adapter shown in FIG. 4a.
  • FIG. 5 is a cross-section view of an adapter for inhalation of the spray.
  • FIG. 1 shows in cross-section. the combination of a valve of a dosage metering pump and an adapter.
  • the adapter is olive shaped and thus suitable for insertion into and spraying of the nose.
  • 1 represents the nose-adapter
  • 2 represents the adapter-channel
  • 3 represents the adapter-nozzle.
  • 4 represents the pressure application surface for manual operation of the device
  • 5 represents the valve of the dosage metering pump of the desired shape and size
  • 6 represents the stem of the valve of the dosage metering pump
  • 7 represents the riser pipe of this valve which is immersed into the content of the container (not shown)
  • 8 represents a threaded cap.
  • a method for operating the device of the invention is described as follows.
  • Stem 6 is pressed downward through the enlarged cavity portion of the adapter channel by pressure exerted on the pressure application surface 4, for instance exerted by the forefinger and middle finger of the hand.
  • the pressure is propagated to the liquid column standing in the metering chamber 5 which column is subsequently forced upwardly through the channel 2 and sprayed out through nozzle 3.
  • the stem 6 abuts the walls of the adapter channel 2 in a pressure tight manner.
  • a spring 13 is shown, which spring is optional.
  • this pressure compresses spring 13 which is held between and abuts against the inside surface of wall 14 and the top surface of wall 15. Then when this pressure is released from the pressure application surface 4, the compressed spring will return the adapter to its starting position, carrying stem 6 upward toward the top portion of the metering chamber 5. This returning movement by stem 6 draws a new charge of the liquid into chamber 5.
  • Adapter 1 is held in place by a clasp means (not shown) which prevents spring 13 from pushing wall 14 beyond the extent of wall 15.
  • FIG. 2 shows a cross-sectional view of an adapter developed for the spraying of the eye.
  • Numbers 1 to 6 have the above-defined meanings as described for FIG. 1; and 9 represents an eye-cup.
  • FIG. 3 shows a cross-section view of the adapter having a shape convenient for spraying the external canal ofthe ear.
  • the numbers 1 to 6 have the same meanings as defined above, while 10 represents the insertion pipe for use in the external canal of the ear.
  • the pipe has a spherical shaped end.
  • FIG. 4a and 4b represent an adapter for the spraying of the charge into the oral and throat cavity.
  • FIG. 4a shows a cross-sectional view of the device, while FIG. 4b shows the top view.
  • the numbers I to 6 have the same meanings as defined above in the aforementioned figures.
  • 11 represents the insertion pipe for use in the oral and throat cavity which pipe is preferably elliptical or rounded and expanding towards the end carrying the nozzle.
  • FIG. 5 shows a cross-sectional view of an adapter for use in spray inhalation.
  • the numbers I to 6 have the same meanings as defined before, while 12 represents the mouth pipe having preferably a cylindrical shape.
  • a device for mechanically spraying a dosage unit of liquid pharmaceuticals or liquid compositions thereof into a body cavity or onto the skin comprising a valve of a dosage metering pump, an adapter positioned with respect to the said valve in a pressure-tight manner, said adapter having a channel therein, a stem abutting said channel walls with a pressure-tight seal and connecting said channel with the valve of the dosage metering pump so as to prevent a loss of pressure, an adapter vortex spray nozzle connected to said channel for producing an exact and equal distribution of the spray, and a pressure application surface on the adapter for manual operation of the device, said dosage metering pump comprising a first wall of diameter greater than the diameter of said valve of said dosage metering pump, and said adapter comprising a second wall of diameter greater than the diameter of said first wall, said first wall being placed in such a spaced relationship to said second wall that said walls overlap, and a spring means held between and abutting against the inside surface of said second wall and the top surface of said first

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Medicinal Preparation (AREA)
  • Closures For Containers (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
US00283511A 1971-08-31 1972-08-24 Device for spraying liquid pharmaceuticals Expired - Lifetime US3820698A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2143471A DE2143471A1 (de) 1971-08-31 1971-08-31 Verfahren und vorrichtung zur mechanisch dosierten applikation von fluessigen arzneimitteln oder arzneimittelloesungen

Publications (1)

Publication Number Publication Date
US3820698A true US3820698A (en) 1974-06-28

Family

ID=5818219

Family Applications (1)

Application Number Title Priority Date Filing Date
US00283511A Expired - Lifetime US3820698A (en) 1971-08-31 1972-08-24 Device for spraying liquid pharmaceuticals

Country Status (22)

Country Link
US (1) US3820698A (sv)
JP (1) JPS4835694A (sv)
KR (1) KR780000281B1 (sv)
AU (1) AU471495B2 (sv)
BE (1) BE788194A (sv)
BG (1) BG20544A3 (sv)
CH (1) CH550588A (sv)
CS (1) CS186211B2 (sv)
DD (1) DD99508A5 (sv)
DE (1) DE2143471A1 (sv)
ES (1) ES406180A1 (sv)
FR (1) FR2154444B1 (sv)
GB (1) GB1408631A (sv)
HU (1) HU168128B (sv)
IE (1) IE36660B1 (sv)
IL (1) IL40254A (sv)
IT (1) IT962272B (sv)
NL (1) NL7211799A (sv)
PH (1) PH11406A (sv)
PL (1) PL78339B1 (sv)
SE (1) SE392036B (sv)
ZA (1) ZA725966B (sv)

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4300545A (en) * 1980-06-23 1981-11-17 Schering Corporation Method and nozzle for nasal vaccination of immature mammals
US4381773A (en) * 1980-06-23 1983-05-03 Schering Corporation Method and nozzle for nasal vaccination of immature mammals
US4860738A (en) * 1982-12-20 1989-08-29 Schering Corporation Hand held metered spray dispenser
US5186368A (en) * 1989-11-07 1993-02-16 Valois Shutter for the outlet channel of a dispenser head for semi-liquid substances, and a dispenser head advantageously associated therewith
US5308343A (en) * 1988-06-23 1994-05-03 Gafner Paul Felix Application device for depositing a liquid substance locally on a surface to be treated
US5590815A (en) * 1995-07-13 1997-01-07 Monturas S.A. Minature pump sprayer
US5666948A (en) * 1993-02-12 1997-09-16 Minnesota Mining And Manufacturing Company Attachment for aerosol device for large animals and method of use
US5921444A (en) * 1994-08-05 1999-07-13 Ing. Erich Pfeiffer Gmbh Dispenser providing treatment surface engagement
US6142342A (en) * 1999-05-28 2000-11-07 Kimberly-Clark Worldwide, Inc. Counter-mounted viscous liquid dispenser having improved reservoir assembly
US6386397B2 (en) * 1998-08-21 2002-05-14 Pharmacia & Upjohn Company Spray bottle grip
US20040164099A1 (en) * 2001-06-29 2004-08-26 Boehringer Ingelheim Pharma Gmbh & Co., Kg Nebulizer for applying liquids on the surface of the eye or the ocular connective tissue
US20060219813A1 (en) * 2003-04-24 2006-10-05 Morrison Robin L Nozzel for a nasal inhaler
WO2007141203A1 (de) * 2006-06-02 2007-12-13 Boehringer Ingelheim International Gmbh Zerstäuber
US20080183145A1 (en) * 2005-04-11 2008-07-31 Helbling Technik Bern Ag Dispensing Device For Delivering Fluid Having a Dosing Chamber and a Slide Valve Assemly
US20100130960A1 (en) * 2008-11-25 2010-05-27 Schering-Plough Animal Health Corporation Method for intranasal administration of a pharmaceutical composition
US20130026191A1 (en) * 2011-07-25 2013-01-31 Aptar France S.A.S. Fluid dispenser
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE8526339U1 (de) * 1985-09-14 1987-05-07 Ing. Erich Pfeiffer GmbH & Co KG, 7760 Radolfzell Austragvorrichtung für fließfähige Medien
DE4008068A1 (de) * 1990-03-14 1991-09-19 Pfeiffer Erich Gmbh & Co Kg Austragvorrichtung fuer medien
US6234167B1 (en) 1998-10-14 2001-05-22 Chrysalis Technologies, Incorporated Aerosol generator and methods of making and using an aerosol generator
US6491233B2 (en) 2000-12-22 2002-12-10 Chrysalis Technologies Incorporated Vapor driven aerosol generator and method of use thereof
US6501052B2 (en) 2000-12-22 2002-12-31 Chrysalis Technologies Incorporated Aerosol generator having multiple heating zones and methods of use thereof
US6681998B2 (en) 2000-12-22 2004-01-27 Chrysalis Technologies Incorporated Aerosol generator having inductive heater and method of use thereof
US6799572B2 (en) 2000-12-22 2004-10-05 Chrysalis Technologies Incorporated Disposable aerosol generator system and methods for administering the aerosol
US6701921B2 (en) 2000-12-22 2004-03-09 Chrysalis Technologies Incorporated Aerosol generator having heater in multilayered composite and method of use thereof
US6568390B2 (en) 2001-09-21 2003-05-27 Chrysalis Technologies Incorporated Dual capillary fluid vaporizing device
US6640050B2 (en) 2001-09-21 2003-10-28 Chrysalis Technologies Incorporated Fluid vaporizing device having controlled temperature profile heater/capillary tube
US6804458B2 (en) 2001-12-06 2004-10-12 Chrysalis Technologies Incorporated Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate
US6681769B2 (en) 2001-12-06 2004-01-27 Crysalis Technologies Incorporated Aerosol generator having a multiple path heater arrangement and method of use thereof
US6701922B2 (en) 2001-12-20 2004-03-09 Chrysalis Technologies Incorporated Mouthpiece entrainment airflow control for aerosol generators
DE102013013397A1 (de) * 2013-08-13 2015-03-12 Epinamics Gmbh Aerosolspender für transdermal wirkende pharmazeutische Zusammensetzungen

Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4381773A (en) * 1980-06-23 1983-05-03 Schering Corporation Method and nozzle for nasal vaccination of immature mammals
US4300545A (en) * 1980-06-23 1981-11-17 Schering Corporation Method and nozzle for nasal vaccination of immature mammals
US4860738A (en) * 1982-12-20 1989-08-29 Schering Corporation Hand held metered spray dispenser
US5308343A (en) * 1988-06-23 1994-05-03 Gafner Paul Felix Application device for depositing a liquid substance locally on a surface to be treated
US5186368A (en) * 1989-11-07 1993-02-16 Valois Shutter for the outlet channel of a dispenser head for semi-liquid substances, and a dispenser head advantageously associated therewith
US5666948A (en) * 1993-02-12 1997-09-16 Minnesota Mining And Manufacturing Company Attachment for aerosol device for large animals and method of use
US5921444A (en) * 1994-08-05 1999-07-13 Ing. Erich Pfeiffer Gmbh Dispenser providing treatment surface engagement
US5590815A (en) * 1995-07-13 1997-01-07 Monturas S.A. Minature pump sprayer
US6386397B2 (en) * 1998-08-21 2002-05-14 Pharmacia & Upjohn Company Spray bottle grip
US6142342A (en) * 1999-05-28 2000-11-07 Kimberly-Clark Worldwide, Inc. Counter-mounted viscous liquid dispenser having improved reservoir assembly
US20040164099A1 (en) * 2001-06-29 2004-08-26 Boehringer Ingelheim Pharma Gmbh & Co., Kg Nebulizer for applying liquids on the surface of the eye or the ocular connective tissue
US20060219813A1 (en) * 2003-04-24 2006-10-05 Morrison Robin L Nozzel for a nasal inhaler
US7484678B2 (en) 2003-04-24 2009-02-03 Glaxo Group Limited Nozzle for a nasal inhaler
US20080183145A1 (en) * 2005-04-11 2008-07-31 Helbling Technik Bern Ag Dispensing Device For Delivering Fluid Having a Dosing Chamber and a Slide Valve Assemly
WO2007141203A1 (de) * 2006-06-02 2007-12-13 Boehringer Ingelheim International Gmbh Zerstäuber
US10124129B2 (en) 2008-01-02 2018-11-13 Boehringer Ingelheim International Gmbh Dispensing device, storage device and method for dispensing a formulation
US20100130960A1 (en) * 2008-11-25 2010-05-27 Schering-Plough Animal Health Corporation Method for intranasal administration of a pharmaceutical composition
US10011906B2 (en) 2009-03-31 2018-07-03 Beohringer Ingelheim International Gmbh Method for coating a surface of a component
US9682202B2 (en) 2009-05-18 2017-06-20 Boehringer Ingelheim International Gmbh Adapter, inhalation device, and atomizer
US10016568B2 (en) 2009-11-25 2018-07-10 Boehringer Ingelheim International Gmbh Nebulizer
US10124125B2 (en) 2009-11-25 2018-11-13 Boehringer Ingelheim International Gmbh Nebulizer
US9724482B2 (en) 2009-11-25 2017-08-08 Boehringer Ingelheim International Gmbh Nebulizer
US9943654B2 (en) 2010-06-24 2018-04-17 Boehringer Ingelheim International Gmbh Nebulizer
US9757750B2 (en) 2011-04-01 2017-09-12 Boehringer Ingelheim International Gmbh Medicinal device with container
US9827384B2 (en) 2011-05-23 2017-11-28 Boehringer Ingelheim International Gmbh Nebulizer
US10040084B2 (en) * 2011-07-25 2018-08-07 Aptar France S.A.S. Fluid dispenser
US20130026191A1 (en) * 2011-07-25 2013-01-31 Aptar France S.A.S. Fluid dispenser
US9545487B2 (en) 2012-04-13 2017-01-17 Boehringer Ingelheim International Gmbh Dispenser with encoding means
US10220163B2 (en) 2012-04-13 2019-03-05 Boehringer Ingelheim International Gmbh Nebuliser with coding means
US10004857B2 (en) 2013-08-09 2018-06-26 Boehringer Ingelheim International Gmbh Nebulizer
US9744313B2 (en) 2013-08-09 2017-08-29 Boehringer Ingelheim International Gmbh Nebulizer
US10894134B2 (en) 2013-08-09 2021-01-19 Boehringer Ingelheim International Gmbh Nebulizer
US11642476B2 (en) 2013-08-09 2023-05-09 Boehringer Ingelheim International Gmbh Nebulizer
US10716905B2 (en) 2014-02-23 2020-07-21 Boehringer Lngelheim International Gmbh Container, nebulizer and use
US10099022B2 (en) 2014-05-07 2018-10-16 Boehringer Ingelheim International Gmbh Nebulizer
US10195374B2 (en) 2014-05-07 2019-02-05 Boehringer Ingelheim International Gmbh Container, nebulizer and use
US10722666B2 (en) 2014-05-07 2020-07-28 Boehringer Ingelheim International Gmbh Nebulizer with axially movable and lockable container and indicator

Also Published As

Publication number Publication date
GB1408631A (en) 1975-10-01
FR2154444A1 (sv) 1973-05-11
NL7211799A (sv) 1973-03-02
CS186211B2 (en) 1978-11-30
IT962272B (it) 1973-12-20
KR780000281B1 (en) 1978-07-24
HU168128B (sv) 1976-02-28
AU471495B2 (en) 1976-04-29
FR2154444B1 (sv) 1978-12-29
IE36660B1 (en) 1977-01-19
BG20544A3 (bg) 1975-12-05
PL78339B1 (sv) 1975-06-30
IL40254A (en) 1975-10-15
ES406180A1 (es) 1975-07-01
DD99508A5 (sv) 1973-08-12
DE2143471A1 (de) 1973-03-08
JPS4835694A (sv) 1973-05-25
AU4612372A (en) 1974-03-07
SE392036B (sv) 1977-03-14
BE788194A (fr) 1973-02-28
PH11406A (en) 1977-12-14
ZA725966B (en) 1974-04-24
CH550588A (de) 1974-06-28
IL40254A0 (en) 1972-10-29

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