US3801818A - Radioactive generator with permeable closure - Google Patents

Radioactive generator with permeable closure Download PDF

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Publication number
US3801818A
US3801818A US00300092A US3801818DA US3801818A US 3801818 A US3801818 A US 3801818A US 00300092 A US00300092 A US 00300092A US 3801818D A US3801818D A US 3801818DA US 3801818 A US3801818 A US 3801818A
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United States
Prior art keywords
generator
closures
radioactive
silicone
neoprene
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Expired - Lifetime
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US00300092A
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English (en)
Inventor
H Hulit
T Czaplinski
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ER Squibb and Sons LLC
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ER Squibb and Sons LLC
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Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
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Publication of US3801818A publication Critical patent/US3801818A/en
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    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/0005—Isotope delivery systems

Definitions

  • the generator comprises a hollow, generally cylindrical body in which a column of radioactive material is contained, and the ends of which are closed by silicone or neoprene stoppers fabricated from material such as methylvinylpolysiloxane or polychloroprene.
  • the generator can be subjected to sterilizing procedures such as autoclaving and retain its sterile condition, while at the same time gases generated internally may be vented through the closures.
  • the present invention relates to-a generator for the production of radioactive eluate,-and more specifically a generator having silicone or neoprene closures to permit the venting of gases internally generated.
  • radioactive isotopes for the diagnosis and treatment of various medical problems.
  • Generators such as that described in U. S. Pat. No. 3,369,121, Feb. 13, 1968, are widely used in the production of radioactive eluate. These generators are utilized since certain radioactive isotopes have a very short half-life and, consequently, it is necessary for the physician to prepare such isotopes as, and where, they are to be used.
  • an isotope is the 99m isotope technetium which is used for the localization of brain tumors.
  • This isotope has a half-life of six hours and is obtained as the daughter product of molybdenum M It is separated in the form of the pertechnetateion from M0 absorbed on an alumina column, by elution with dilute hydrochloric acid or saline.
  • gases may be internally generated. These gases reduce the isotope yield of the generator and, in any event, must be removed for the obtainment of eluate.
  • the present invention utilizes silicone or neoprene closures which are pervious to the generated gases. At the same time the silicone or neoprene closures may be subjected to any popular sterilizing technique such as autoclaving and resist the inflow of any bacteria. In sum mary, the silicone or neoprene stoppers are gas pervious yet maintain generator stability.
  • the stoppers are pierceable so as to admit solution for the production of the radioactive isotope.
  • the stoppers are sufficiently pervious to vent any and all gases internally generated.
  • the stoppers may be subjected to any preferred sterilizing technique, such as autoclaving, and will effectively maintain sterile conditions at all times.
  • FIG. 1 is a partially cross sectioned view of a preferred embodiment.
  • FIG. 2 is a perspective view of an individual closure.
  • the present invention is associated with a radioactive material generator similar to that shown and described in U. S. Pat. No. 3,369,121.
  • the radioactive material generator comprises a column 10 fabricated from a plastic or similar type material.
  • the column 10 has a shell 12 and is surrounded by a plurality of integral fins 14.
  • the column 10 is closed by stoppers 16, 18, which are pervious to the passage of gas therethrough and may be made from silicone or neoprene, of which more will be described at a subsequent point.
  • the curvilinear partition 20 which basically separates it into two parts, the upper part 22 and the lower part 24.
  • the partition 20 can be integral with the shell 12 or suitably attached thereto, and it tapers from section 22 toward section 24 providing a rather restricted opening 26 at the bottom thereof.
  • the exact dimensions of the partition are unimportant, however, it has been found that it should extend a slight distance below the top of a breather tube 28 which punctures closure 18, which breather tube permits the interior of section 24 to communicate with the atmosphere.
  • the breather tube is fitted with a suitable filter material 30 which prevents the flow of bacteria to the interior of the shell 12.
  • a disc 32 Positioned at the upper end of the partition 20 is a disc 32, which must be perforated, and on which rests a filter pad 34.
  • a filter pad 34 At the top of filter 34 is a granulated radioactive alumina 36, and optionally, a cation exchange resin such as Dowex-SO x8 to prevent the passage of the alumina through the column during elution.
  • the granulated alumina 36 may be retained in place by use of a perforated disc 38 which is held in place by a retaining ring 40.
  • eluent is emitted from the eluent container 42 into section 22 via the hypodermic needle 44 which pierces closure 16.
  • the hypodermic needle 46 withdraws the radioactive solution that has been prepared in section 22 and passed to section 24.
  • the closures 16, 18 are in the nature of circular plugs with a central depression 50 and a circular flange 52.
  • the closures are c'lose-fittedly received within compatible openings in the top and bottom of column 10 and are maintained in place by the cover members 54, 56 which are preferably fabricated from ductile metals and which are crimped thereabout; the covers 54, 56 engage the shoulders 54a, 56a permanently maintaining the closures l6, 18 in their respective positions in the column.
  • the silicone or neoprene is easily pierced by hypodermic needles and is essentially completely selfsealing
  • the particular silicone chosen is preferably one of the organopolysiloxanes, notably methylvinylpolysiloxane, one of the Dow Corning Silastic brand. These closures are useful over a wider temperature range than any other rubber-like material, for instance, they retain their physical properties in a low and high temperature range of lF to 500F and therefore can be autoclaved.
  • the particular neoprene chosen is preferably polychloroprene manufactured by the Tompkins Rubber Co.
  • the yield of radioactive solution of any given generator is strikingly increased by the use of the silicone or neoprene closures.
  • the radioactive materials involved have relatively short half-lives and any time wasted venting gases results in an under utilization of the generator.
  • the stoppers therefore, not only permit the simple venting of the trapped gases and elimination of additional hypodermic needles, but they effectively increase the yield of a given generator.
  • a generator containing a column of sterile elutable radioactive material to be utilized for diagnosis and treatment for medical conditions said generator of the type which comprises a hollow body closed at its top and bottom by pierceable autoclavable closures and having positioned therein and spaced from the bottom thereof a source of elutable, short-lived radioactive material, whereby a sterile eluate ready for utilization is delivered from the body, the improvement which comprises said autoclavable closures being fabricated from material which is pierceable, and gas pervious permitting the venting directly through said closures of gases formed in the generator, said closures being sufficiently dense to prevent the passage of fluid directly therethrough as well as preventing the inflow of bacteria therethrough.
  • closures are fabricated from methylvinylpolysiloxane.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Measurement Of Radiation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
US00300092A 1972-10-24 1972-10-24 Radioactive generator with permeable closure Expired - Lifetime US3801818A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30009272A 1972-10-24 1972-10-24

Publications (1)

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US3801818A true US3801818A (en) 1974-04-02

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Family Applications (1)

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US00300092A Expired - Lifetime US3801818A (en) 1972-10-24 1972-10-24 Radioactive generator with permeable closure

Country Status (6)

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US (1) US3801818A (enrdf_load_stackoverflow)
CA (1) CA994013A (enrdf_load_stackoverflow)
CH (1) CH588285A5 (enrdf_load_stackoverflow)
FR (1) FR2203614B1 (enrdf_load_stackoverflow)
GB (1) GB1453291A (enrdf_load_stackoverflow)
SE (1) SE399332B (enrdf_load_stackoverflow)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4393864A (en) * 1980-02-13 1983-07-19 Thomas Jefferson University Syringe shields and methods for using same
US4638809A (en) * 1984-03-22 1987-01-27 Kuperus John H Method of preparing radionuclide doses
US5038046A (en) * 1990-07-10 1991-08-06 Biotechnetics Method and generator for producing radioactive lead-212
US5109160A (en) * 1990-10-12 1992-04-28 E. I. Du Pont De Nemours And Company Sterilizable radionuclide generator and method for sterilizing the same
US20080203318A1 (en) * 2005-07-27 2008-08-28 Wagner Gary S Alignment Adapter for Use with a Radioisotope Generator and Methods of Using the Same
US20100133269A1 (en) * 2005-06-24 2010-06-03 Salvatore Moricca Method and apparatus for isolating material from its processing environment

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3133196A (en) * 1959-10-29 1964-05-12 Gen Electric Radioactive heat source and container with helium permeable window in the container
US3156532A (en) * 1961-06-30 1964-11-10 Robert F Doering Yttrium-90 generator
US3369121A (en) * 1966-04-06 1968-02-13 Squibb & Sons Inc Radioactive package and container therefor

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3133196A (en) * 1959-10-29 1964-05-12 Gen Electric Radioactive heat source and container with helium permeable window in the container
US3156532A (en) * 1961-06-30 1964-11-10 Robert F Doering Yttrium-90 generator
US3369121A (en) * 1966-04-06 1968-02-13 Squibb & Sons Inc Radioactive package and container therefor

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4393864A (en) * 1980-02-13 1983-07-19 Thomas Jefferson University Syringe shields and methods for using same
US4638809A (en) * 1984-03-22 1987-01-27 Kuperus John H Method of preparing radionuclide doses
US5038046A (en) * 1990-07-10 1991-08-06 Biotechnetics Method and generator for producing radioactive lead-212
US5109160A (en) * 1990-10-12 1992-04-28 E. I. Du Pont De Nemours And Company Sterilizable radionuclide generator and method for sterilizing the same
WO1992007365A1 (en) * 1990-10-12 1992-04-30 E.I. Du Pont De Nemours And Company Sterilizable radionuclide generator and method for sterilizing the same
US20100133269A1 (en) * 2005-06-24 2010-06-03 Salvatore Moricca Method and apparatus for isolating material from its processing environment
US8662338B2 (en) * 2005-06-24 2014-03-04 Australian Nuclear Science And Technology Organisation Container for receiving a substance including nuclear material
US20080203318A1 (en) * 2005-07-27 2008-08-28 Wagner Gary S Alignment Adapter for Use with a Radioisotope Generator and Methods of Using the Same

Also Published As

Publication number Publication date
CA994013A (en) 1976-07-27
FR2203614A1 (enrdf_load_stackoverflow) 1974-05-17
GB1453291A (en) 1976-10-20
SE399332B (sv) 1978-02-06
FR2203614B1 (enrdf_load_stackoverflow) 1978-02-10
CH588285A5 (enrdf_load_stackoverflow) 1977-05-31

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