US3737096A - Blood processing control apparatus - Google Patents

Blood processing control apparatus Download PDF

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Publication number
US3737096A
US3737096A US00211194A US3737096DA US3737096A US 3737096 A US3737096 A US 3737096A US 00211194 A US00211194 A US 00211194A US 3737096D A US3737096D A US 3737096DA US 3737096 A US3737096 A US 3737096A
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Prior art keywords
centrifuge
blood
motor
relay
pump
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US00211194A
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English (en)
Inventor
A Jones
G Judson
R Kellogg
V Kruger
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Terumo BCT Inc
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International Business Machines Corp
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3692—Washing or rinsing blood or blood constituents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3698—Expressing processed fluid out from the turning rotor using another fluid compressing the treatment chamber; Variable volume rotors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/64—Containers with integrated suction means
    • A61M1/68—Containers incorporating a flexible member creating suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/025—Means for agitating or shaking blood containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0429—Red blood cells; Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/1483—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags using flexible bags externally pressurised by fluid pressure

Definitions

  • BLOOD PROCESSING CONTROL APPARATUS [75] lnventors: Alan L. Jones, Endwell; George T. Judson, Whitney Point; Robert M. Kellogg, Endwell; Victor R. Kruger, Apalachin, all of N.Y.
  • ABSTRACT Apparatus for processing blood, and particularly for washing blood cells including a centrifuge head in which is arranged a flexible blood container connected by a rotating seal to tubing which permits the entrance and exit of wash liquid and supernatant.
  • the flexible container fits over a flexible membrane also arranged inside the centrifuge head about a solid central core.
  • the volume defined by this membrane and the core communicates via a passage in the core with a fluid reservoir by means of a control pump which allows fluid to enter and exit from the volume defined by the membrane.
  • the unwashed blood may be entered into the container or blood bag before or after the bag is placed in the centrifuge.
  • the centrifuge is spun until cells have settled against the outside wall at which time the valve arrangements and the control pump are activated such that fluid is pumped into the centrifuge under the volume defined by the membrane thereby forcing a supernatant to flow out to a collect container.
  • the centrifuge is then stopped and the wash solution enters the blood container through another valve arrangement, thereby a1- lowing the removal of fluid from the volume inside the flexible membrane. Removal of the wash liquid is accomplished by the same process of removal as the removal of supernatant previously described.
  • the circuit arrangements are such that a high degree of flexibility in the programming of the various operations can be obtained.
  • This invention relates generally to blood processing apparatus, and in particular, to an improved arrangement for processing previously frozen blood cell volumes for transfusion.
  • red blood cells can be extended by freezing the cells prior to storage and subsequent thawing, with the addition of an appropriate additive to protect the cells during these processes. Most of these additives must be removed from the cells before they are transfused to a recipient. This washing can be done by washing the cells with various solutions and resuspending the the cells in the isotonic saline solutions, albumin, or plasma.
  • the principal deterrent heretofore to the widespread use of frozen red blood cells is the lack of an easy-to-use, inexpensive cell washing method with all parts which come in contact with the blood being'disposable and sufficiently economical that they may be disposed after a single use.
  • The'present invention is an improvement on the configuration shown in the IBM Technical Disclosure Bulletin for December 1967 at pages 944 and 945, in that a completely designed apparatus, arranged for either manual or automatic programming is provided by the present invention.
  • a more particular object of the present invention is to provide an improved blood washing system which is economical in construction and which utilizes disposable elements for those parts which come in contact with the blood.
  • Still another object of the present invention is to provide a blood washing system which can provide a plurality of different operations all selectable by the machine operator.
  • Yet another object of this invention is to provide an improved blood processing apparatus in which automatic programming of the various cycles of operation can be utilized.
  • Still another object of the invention is to provide a blood cell washing system of the centrifuge type, employing a disposable centrifuge container.
  • a centrifuge container or bowl having a vertical shaft, in the upper portion of which a flexible membrane is provided which can communicate with the hydraulic reservoir via the hollow core of the centrifuge shaft.
  • the centrifuge is arranged to be rotated by an electrical motor arranged so that it can be accelerated, decelerated and reversed.
  • a centrally-located rotating seal device permits fluid to enter or leave the flexible container while the container is being rotated. By the supply of suitable hydraulic fluid to the underside of the flexible membrane, the volume of the blood container can be varied during the washing process.
  • a plurality of valves are provided for controlling the inlet and outlet of fluids to and from the blood container, as well as controlling the flow of hydraulic fluid from the enclosed space below the flexible membrane, to the fluid reservoir.
  • the hydraulic fluid is pressurized by a suitable control pump, preferably of the piston type driven by an appropriate drive mechanism such as, for example, a rack and pinion motion operated by a suitably controlled reversible electric motor, whereby the amount and direction of hydraulic flow can be varied.
  • the apparatus also includes a plurality of electrical circuits including timing mechanisms which may be connected by appropriate wiring and switching means to provide a flexible programming ability so that the operator may vary the sequence and length of the steps in the washing process.
  • the sequence and timing may be governed by manually operated switches, or by automatic sequence control cir- I cuits.
  • FIG. 1 is a highly-schematic illustration of a blood cell washing system illustrating the broad principles of the present invention
  • FIG. 2 is an elevational view of the centrifuge bowl and its supporting shaft elements
  • FIG. 3 is a diagrammatic plan view of the apparatus, showing the top of the centrifuge bowl, and a view of the operators control panel as seen from above;
  • FIG. 4 is a diagrammatic front elevational view, showing the hydraulic fluid control pump and reservoir, along with certain components of the electrical control system and illustrating the placement of the centrifuge and the operators panel with respect to this portion of the machine;
  • FIG. 5 is a diagrammatic elevational view looking from the right-hand side of the machine, in which further detail of the hydraulic control pump drive and the centrifuge drive can be seen;
  • FIG. 6 is a diagrammatic elevational view of the machine from the left-hand side, showing the centrifuge drive, the rack and pinion control pump mechanism, a portion of the hydraulic apparatus and some compo nents of the electrical power supply;
  • FIG. 7 is a front elevational view of the operators control panel, which includes the pinch-off type of valve mechanisms
  • FIG. 8 is a schematic illustration of the motor drive and other auxiliary circuits in the machine.
  • FIGS. 9a and 9b when joined in the manner shown, form a diagrammatic illustration of a portion of the control circuits for the machine.
  • FIG. 10 is a diagrammatic illustrating of additional control circuit employed in the machine.
  • FIG. 11 is a diagrammatic illustration of an interface detector circuit employed in the machine.
  • FIG. 1 of the drawings there is shown in highly schematic form an illustration of a blood cell washing device showing some of the elements of the present invention.
  • Centrifuge CC comprises a centrifuge bowl 1, provided with a suitable cover and having a flexible membrane 7 therein, separating the bowl into upper and lower portions.
  • the upper portion also receives a flexible blood cell container, the walls of which are co extensive with the flexible membrane and the upper portion of the centrifuge bowL
  • This container is connected via a rotating seal RS to a tubing system which is connected to a plurality of fluid receptacles, which can contain various types of washing fluid such as Wash 1, Wash 2, and Wash 3, and also a waste receptacle designated waste.
  • the blood container can communicate with any one of these receptacles via separate and independently operable valves V1, V2, V3 and V4.
  • the permanent seal PS provides an appropriate scalable connection between the rotating portion of the centrifuge and the stationary hydraulic apparatus, which includes the hydraulic control pump HP, a hydraulic reservoir HR and one or more valves such as the valve V5.
  • the pump is arranged to be reversible and it will be apparent that the volume of hydraulic fluid contained within the space defined by the flexible membrane 7 can be altered by pumping fluid in or out of the space by suitable operation of the control pump HP and the valve V5. Accordingly, the effective volume of the centrifuge chamber can be controllably varied. Asindicated in the drawing, during centrifuging, the blood cells are forced to the wall of the blood bag or container and the centrifuge wall by a centrifugal force occurring during rotation of the centrifuge bowl.
  • the wash solutions may be admitted to the bag via valves V1, V2 or V3, and supernatant solution may be delivered to the waste receptacle via the valve V4.
  • the drive mechanism connected to the centrifuge CC is arranged to either spin the centrifuge head at a constant speed or to vary the speed and/or direction of rotation of the head in an agitation cycle.
  • the blood bag is placed in a centrifuge either already filled with the blood cellcryopreservative mixture or filled via the tubing and seal connections. Thereafter the centrifuge is spun until the cells have settled against the outside wall. During the spinning operation the valve V5 which connects the volume under the flexible membrane to the fluid reservoir is open. When the centrifuge bowl begins to spin, the blood cell mixture in the flexible container will be pressed against the outside wall of the centrifuge bowl. This will result in a negative pressure in the fluid'system under the flexible membrane.
  • valve V5 is again opened. Therefore, fluid may drain from the centrifuge bowl to the reservoir faster than the hydraulic fluid pump rate. This process may be continued as many times as desired and the operation of the entire system is readily and variably controlled either by manual control or through the internal programming of the system, to be described in detail subsequently.
  • FIG. 2 of the drawings there is shown an elevational view of the centrifuge bowl and its contents, as well as the supporting structure for the rotating apparatus and the seals which permit the flow of hydraulic fluid and also of the blood and was solutions.
  • Reference character 11 denotes the upper wall
  • reference character 13 denotes the lower wall of theflexible blood bag or container shown shown in a nearly-empty condition within the centrifuge structure. Beneath this bag is the flexible membrane 15, below which hydraulic fluid is admitted from openings which communicate with the central core of the centrifuge shaft.
  • the tubing 17 is connected to the hydraulic pumps and fluid reservoir via appropriate valves, as will be subsequently described.
  • the tube 19 leads from the flexible blood bag to a disposable rotating seal, now shown which provides communication between the blood bag while in the centrifuge and the various reservoirs via the valve mechanisms located on the operators panel.
  • the centrifuge is covered by a cover 21, which is held on by anysuitable clamping means, such as a plurality of screws using a combined slot and hole technique for permitting relatively rapid removal and replacement of the cover.
  • anysuitable clamping means such as a plurality of screws using a combined slot and hole technique for permitting relatively rapid removal and replacement of the cover.
  • two or more upstanding bosses 23 are provided, from the upper surface of the centrifuge central element, and openings or holes in the blood bag, with their edges appropriately sealed, are provided to fit down over these bosses or studs. In this manner, when the cover 21 is then put in place thebag will be retained in position.
  • a drive pulley is located on the lower portion of the centrifuge shaft, which rides in a bearing assembly 25, and a roller bearing 27 acts as a bearing against lateral or axial thrust.
  • the drive pulley located on the lower end of the shaft is belted to a suitable drive motor, by which the entire centrifuge assembly may be spun at relatively high speeds.
  • the tubing 17 communicates with the hollow interior of the centrifuge shaft via the seal connections PS, which provide for a suitable passage of hydraulic fluid into the interior of the rotating centrifuge shaft, as previously explained.
  • FIG. 3 of the drawings is a top plan view of a blood washing machine in accordance with the present invention.
  • One manner of attachment of the cover plate to the bowl portion of the centrifuge is clearly illustrated in this figure, showing the plurality of hold-down screws, which cooperate with a slot and hole arrangement in the cover so that the cover may be placeddown over the screws, rotated clockwise to engage the slots, and thereafter the screws may befastened to securely hold the cover in place during the centrifuging operation.
  • the bosses 23, which center and align the blood container, are shown, as well as the center connection 19, where the tubing is attached tothe blood container.
  • a pair of sliding transparent doors 27 and 29 are arranged to meet at the center of the machine with a suitable opening for the connection 19, so that the top of the centrifuge can covered during operation.
  • the outline of the centrifuge drive motor is shown in dotted lines in this figure.
  • the top view of the hydraulic control pump assembly which is here constituted, comprises a pair of cylinders 31, with pistons tied by a yoke 33 at the top end thereof, which in turn is fastened to a rack 35.
  • the rack is moved up and down by a pinion driven by a motor and gear assembly 37, so that by suitable circuit control the hydraulic control pump may be utilized to either force fluid into the centrifuge bowl or remove it therefrom. Certain of the fittings to the pump may also be seen in this view.
  • FIG. 4 of the drawings shows a front elevation view of the machine.
  • the relationship between the pump cylinders, piston rods and the rack drive for the control pump may be clearly seen.
  • a limit switch 39 is provided, which indicates the upper limit of travel of the pump pistons. This indication is used in the control circuitry to be subsequently described.
  • FIG. 4 additionally shows the location of the hydraulic fluid reservoir 41, as well as certain of the electrical components. The transformers shown on the lower left portion of the figure are utilized in the power supplies for the machine.
  • a recessed enclosure containing a plugboard 43 by which varying operating programs may be arranged at the convenience of the operator by connecting the various jacks with suitable jumper wires.
  • a stepping switch 45 is also visible in this figure, this stepping switch being utilized in conjunction with the plugboard 43 for automatic program control.
  • Reference character 47 designates a relay mounting gate, which is utilized for mounting the various relays utilized in the control of the electrical portion of the machine.
  • FIGS. 5 and 6 are the right-side and left-side views, respectively, of the machine.
  • the drive motor 49 for the centrifuge is shown toward the center of the machine, driving the centrifuge by a pulley 51 and drive belt 53, which rotates a driven pulley on the centrifuge shaft.
  • the centrifuge drive motor is provided with suitable control circuitry which allows the speed and direction of rotation of the, motor to be variably and accu-. rately controlled.
  • the components shown in the lower portion of FIG. 6 are electronic elements which are utilized in the power supplies of the machine and since their actual construction is not germane to the present invention, they are not described in detail.
  • the present invention comprises apparatus for the washing of preservatives or other materials from a single unit volume of red blood cells.
  • the cells are diluted with a wash solution, mixed, and then centrifuged to separate the wash solution from the cells. The supernatant is then removed and a new wash solution is entered. This is therefore a batch-oriented apparatus.
  • an empty blood bag is placed in the centrifuge bowl.
  • the bag is connected to the cell mixture, the wash solutions and the supernate collect container via a flexible tubing harness arrangement.
  • the cell mixture is then run into the bag by gravity.
  • the cells sediment to the outside of the bag with the supernatant (or plasma) collecting at the center. After sufficient sedimentation, the waste valve is opened 'and the control pump is started. This forces the flexible membrane against the bottom of the blood bag, expelling supernatant. The volume of supernatant expelled is controlled by the amount of fluid pumped under the flexible membrane. Centrifuge rotation continues.
  • a first wash cycle starts as follows: the centrifuge is braked to a low speed. The machine senses this low speed, the first wash valve opens, the pump reverses, the bowl goes into an agitate cycle. Since the pump has been reversed, hydraulic fluid is now being removed from under the membrane. This in turn allows wash solution to run by gravity into the blood bag. The 37 agitate or oscillation of the bowl serves to mix the cells and the incoming wash solution during this time.
  • the cell'washer can provide either packed cells or resuspended cells depending on where the process is stopped.
  • the operation of the blood cell washer is controlled from a console on top of the machine, illustrated in FIG. 7 of the drawings.
  • the various controls and indication lights include:
  • POWER ON Light 55 Indicates the machine power is on.
  • READY Light 57 This light must be on before the machine can be started. There may be several seconds delay between power on and ready” on. It indicates that the sliding covers are closed and that other functions are ready for operation.
  • AUTOMATIC/MANUAL Switch 59 This twoposition switch sets the machine in either a manual or automatic mode.
  • AGITATE/WASH IN 67 Lighted Pushbutton Initiation of this function can occur only from the SUPERNATE OUT mode of operation. If in the MANUAL mode, transfer into the AGITATE/- WASH IN mode occurs by pressing the AGITA- TE/WASH IN pushbutton. In the AUTOMATIC mode, transfer occurs automatically upon activation of the end-of-travel switch on the hydraulic pump assembly or detection of the red cell interface by the photo detect assembly 103 and 107; but it can be initiated manually by pressing the button at any time while in SUPERNATE OUT.
  • STOP 73 Lighted Pushbutton Initiation of this function is at the end of a run or if it is desired to halt a run prematurely.
  • STOP can be activated from any of the operational modes. Initiation of STOP aborts the run completely.
  • the STOP light ON in pushbutton '73 indicates an abnormal condition. The only time the STOP light will come on is when either the home position or end-of-travel switch has failed and the control pump has driven past these switches to hit the pump over-drive safety switches. When this occurs, the machine will stop all functions.
  • the tubing leading from the rotating seal RS to the plurality of solenoid valves passes through the interface detector. This detector determines when the blood cells are beginning to be pumped out of the flexible container during the SUPERNATE OUT mode.
  • CENTRIFUGE SPEED CONTROL 63 This controls centrifuge speed.
  • PUMP SPEED CONTROL 75 This controls the pumping rate for SUPERNATE OUT to WASTE.
  • the SUPERNATE OUT pumping rate should not exceed the gravity fill rate of the WASH SOLU- TIONS.
  • SOLUTION SELECTOR SWITCH 37 This threeposition switch selects either V1, V2 or V3 solenoid operated valves during AGITATE cycle in the MANUAL mode of operation. The selected solenoid valve will energize, opening a path for fluid to flow from the wash solution containers to the blood bag in the centrifuge. This is inoperative during AUTOMATIC mode.
  • the solenoid valves are provided with pinch levers,
  • valves are accordingly, indicated as V1, V2, V3 and V4 in FIG. 7.
  • SPIN TIMERS STl, ST2 These timers are only operable in the AUTOMATIC mode of operation. They control the length of the spins. Two timers are available. SPIN TIMER STl permits spins up to 15 minutes in length. SPIN TIMER ST2 permits spins up to 4minutes in length.
  • the programmable plugboard 43 is jumper-wired to select the desired timer for each SPIN mode cycle.
  • PROGRAMMABLE PLUGBOARD 43 The programmable plugboard allows the operator to specify the order of the wash solutions used and the length of the spins when in AUTOMATIC operation. The upper half controls the order of the washes. A jumper wire from the first column to either of the other three columns indicates which wash valve will open during that AGITATE/WASH IN cycle. The lower half of the plugboard indicates which spin timer controls each spin cycle. If the machine is in MANUAL operation, the condition of the plugboard is immaterial.
  • the sliding covers over the centrifuge well are rolled out of the way and the cover of the centrifuge is then removed.
  • the bag can then be placed in the bowl.
  • the two large holes in the bag are placed snugly over the raised bosses and the edge of the bag is pressed into the bowl as far as possible. If there are too many wrinklesin the bag, it will not be possible to put the maximum amount of blood into the bag.
  • the neck of the bag with the integrally connected seal is then threaded up through the hole in the center of the cover and the cover is then replaced. When the plastic covers are closed, they hold the seal in place.
  • the tubing harness is placed in the valves on the console and connected to the stem from the bag after removing the cap from the bag stem.
  • the blood can flow into the bag from a side tee" connection or may be connected through the Wash 1 valve. In either case, this line is opened and the blood allowed to flow into the bag.
  • the SO- LUTION SELECTOR 77 is placed to the appropriate position and the CENTRIFUGE SPEED CONTROL 63 and the PUMP SPEED CONTROL set to their desired values. Also, the upper limit switch is set so that the desired volume of supernatant will be pumped out. The position of the upper limit switch can be changed by rotating the knob 79. The first SPIN can then be initiated. After the cells have sedimented sufficiently, the
  • SUPERNATE OUT button is pressed. The supernate will continue to flow to waste until the AGITATE/- WASH IN button is pressed or the pump hits the UPPER LIMIT SWITCH or cells are detected by the INTERFACE DETECTOR. When the supernate has been removed, the AGITATE/WASH IN button is pressed. One of the wash solutions (according to the position of the SOLUTION SELECTOR SWITCH) will flow into the bag until the SPIN is pressed or the pump hits the lower limit switch. These steps are repeated until the last SUPERNATE OUT step is completed. At this time, packed cells are available.
  • the packed cells can be reconstituted by turning the SELECTOR SWITCH to that position and pressing the AGITATE/- WASH IN button. To shut the machine down, the STOP button is pressed. This will stop the centrifuge and send the pump to the home position. The sliding covers can then be opened and the centrifuge bowl cover removed. The tubing harness is disconnected and is removed. The bag is then removed from the machine and the cells are ready for use.
  • the machine is prepared as described above.
  • the programmable plugboard on the front of the machine is appropriately wired.
  • the SPIN TIMERS STl and ST2 must be set for the desired lengths of spin.
  • the upper limit switch on the pump is set at the desired waste volume by turning the large knob 79 on top of the console. Each turn of the knob will alter the setting by some predetermined amount. Turning this knob clockwise raises the switch and increases the volume pumped. Counterclockwise rotation of the knob decreases the volume.
  • the machine is started by pressing the START/SPIN button 61. Form this point on, the operation is automatic.
  • the bowl will spin until the. time elapsed is that preset by the program timer.
  • the WASTE valve will open and the pump will start. Supernatant will be pumped to WASTE until the upper limit switch is operated or cells are reused at the INTERFACE DETECTOR.
  • the pump will reverse and the first wash solution will be allowed to flow into the bag.
  • the bowl starts agitating thereby mixing the cells with the incoming wash solution.
  • the AGITATE mode will continue until the lower limit switch on the pump is tripped at which point the bowl goes into the second spin. This continues until the last supernatant has been removed, at which time the machine shuts down.
  • the CENTRIFUGE SPEED 63 is set to zero.
  • the upper limit switch is adjusted for maximum hydraulic pump drive travel (full clockwise rotation on the knob) and START/SPIN button 61 and the SUPERNATE OUT button 65 are depressed.
  • PUMP SPEED is set to zero and the STOP button 73 is pressed.
  • the PUMP SPEED 75 is set to maximum.
  • the machine is ready for use when the READY light goes on.
  • FIG. 8 of the drawings there is shown the details of the power supply circuitry and the motor control circuitry for control of the pump motor and the centrifuge motor.
  • Power at the conventional line voltage and frequency is supplied over a pair of input conductors L1 and L2, and through a main power switch S1, protected by a line fuse F1, from whence it is distributed to a plurality of elements each having an associated fuse bearing the references F2 through F6.
  • the pump motor control circuit includes a fullwave motor control governed by the pump speed control 75, and supplying power to the pump motor field and also through a plurality of braking and reversing contacts to the pump motor armature.
  • Power for the operation of the various control circuits is obtained by a conventional 48-volt DC. power supply, supplying energy to the terminals designated +48 and COMMON, which will appear at various points throughout the circuit drawings.
  • a continuouslyrunning motor which operates cam contacts for determining the agitation cycles is connected to the power busses through fuse F5 as shown.
  • the centrifuge motor is connected to a full-wave motor control governed by the operation of centrifuge speed control 63, with direction, speed and braking being governed by contacts of relays HDl, HD2 and HD3.
  • Relays HD2 and HD3 also serve to connect the winding of a speed sensing relay designated SSR across the centrifuge motor at specified times.
  • the sequence of operation of the machine is governed by a plurality of relays which are governed by circuitry shown in FIGS. 9a and 9b, arranged in that order from left to right, so that the corresponding circuit lines match on the drawings, as well as additional timing and stepping relay circuitry shown in FIG. 10 of the drawings.
  • the relay circuitry is generally arranged so that a proper sequence of steps must be followed either during automatic or manual operation of the machine, as insured by appropriate logical interlocking of the control circuits for the various relays controlling the different modes of operation. It is considered that the description of these circuits will be enhanced by describing the operation of this portion of the machine under different operating conditions.
  • the main power on switch In readying the machine for operation, the main power on switch must be turned on to energize the relay power supply, thereby supplying a 48-volt output from the power supply shown in FIG. 8. At this time the ill power on light L1, shown in FIG. 90, lights. Also, at this time the ready light L2 will come on assuming that the pump is in its home position and the sliding covers on the centrifuge are closed. This action is obtained by the use of relays R1 and R14.
  • Relay R1 is controlled by contacts on the pump home position switch SW3, and contact on the end of the travel switch, SW2. With the stop relay R12 de-energized, a circuit can be traced through the normally closed contacts of relay R12 and through the home position switch and the end-of-travel switch to pick the ready relay R1. With the covers closed, the cover interlocks switches S15 and S16 will be closed and relay R14 will be energized, and with relay R1 energized, a circuit is established for lighting ready light L2.
  • the pump If the pump is not in its home position at the time the main power switch is on, it will go to the home position, providing the pump speed control knob is not set at zero. When it does reach the home position, the home limit switch will close and complete the circuit to energize relay R1, thereby establishing the ready condition and turning on the ready light.
  • the machine is now ready for use either in manualor automatic mode, as determined by the setting of the manual or automatic switch.
  • the desired centrifuge speed is set on the centrifuge control.
  • the desired wash solution is selected by the solution selector switch after which the spin control pushbutton is operated. This is the only function that can be activated at this time, as the first step after ready condition, because all functions are interlocked to only permit sequencing from start through the supernate out and agitate cycles.
  • Initiation of the spin by operation of spin pushbutton establishes a circuit to energize relay R2, which in turn energizes relays HDl and I-ID2.
  • relay R2 which in turn energizes relays HDl and I-ID2.
  • HDl establishes the direction of spin and I-ID2 connects the output of the motor controller across the centrifuge drive armature, as shown in FIG. 8.
  • the output of the controller is established by the setting of the centrifuge speed control knob on the operators console. The centrifuge will then start and accelerate up to the preestablished speed and maintain its speed there until the SUPERNATE OUT switch or the STOP switch is operated.
  • relays R4 and R5 Operating the AGITATE/WASH IN button, energizes relays R4 and R5 through suitable logic function circuits and causes each to hold through a holding circuit including one of their own normally open contacts.
  • relay R4 When relay R4 is picked up, it releases relays l-lDl and I-ID2.
  • dynamic motor braking is effected for the centrifuge motor. Current flowing in the brake circuit is sensed by the coil of the speed sense reed relay SSR, shown in FIG. 8. This will operate the reed relay which in turn energizes relay Rll.
  • Relay R11 will remain picked until the centrifuge speed reaches some predetermined low level, perhaps a few rpm, as determined by the armature back emf and the number of turns on the coil of the speed sense reed relay.
  • relay R11 When the reed relay opens because of low brake current, relay R11 is de-energized and drops out.
  • relay HD3 will be picked through position 1-2 contact of the agitate control timer.
  • Relay HD3 will establish a holding circuit through one of its own normally open contacts and supplies energy from the 48- volt power supply to the centrifuge motor circuit via the direction reversing contacts HDl.
  • relay HDl will be alternately picked up and released by the closing and opening of a cam-operated contact on the agitate control timer position 1-1.
  • the relay R11 When the relay R11 was released, it also opened one of the wash solution solenoids.
  • the particular'wash solution selected is determined by positioning of the manual wash solution selector switch.
  • These solenoids are energized through an RC network allowing the solenoid to pick at a value close to 48 volts, but holding through the dropping resistor at approximately 20 volts.
  • the cycling of relay l-IDI will cause the centrifuge to oscillate to thereby agitate the solution in the blood bag.
  • the normally closed point of relay R12 applies 48 volts to the pump home position switch to the end-of-travel switch and to a set of normally closed points on relay R1. If relay R1 is not operated, which means the pump is not in the home position, the normally closed relay R1 point will supply the energy to relay R7, causing the pump to return to the home position. The various controls except hold are inoperative until the pump reaches the home posi-- tion. When this position is reached, the home pump switch is operated and energizes relay R1, which lights the ready light, as previously explained and releases relay R7. At this time the machine is now ready for use again.
  • the hold condition can be initiated at any time, but its action will be different depending upon the particular mode of machine operation. If the machine is in the SPIN mode, there is no visual change in the machine operation except that relay R8 is energized. Under these conditions the operator cannot proceed to another step except by operating the button CONTINUE, which will drop out relay R8. If the machine is in the SUPERNATE OUT mode, operation of the HOLD button stops the pump by picking relay R8, which removes power from the pump motor. Other functions will continue, and if the CONTINUE pushbutton is operated at this time, the machine will proceed in the SUPER- NATE OUT mode. If the machine is in the AGITATE mode, operation of the HOLD switch will again stop the pump as a result of relay R8 picking. Relay R9 picks when relay R8 holds. This removes power from the agitate control timer and the hold circuit of HD3. Taken together, these two events will stop the centrifuge agitation operation.
  • stop light L7 does not light.
  • emergency stop switches S12 and/or S13 which are located at the extreme ends of upper and lower travel of the pump piston, act to light the stop light and also to pick relay R12, thus, causing the machine to stop.
  • the machine can only be restored to normal operation by manually turning the shaft of the pump motor by hand to move the pump piston shaft away from the emergency stop switches. At this time, of course, it would be necessary to check for and eliminate the cause of the overtravel.
  • the timers STl and ST2 on the operators console are set, the plugboard is appropriately wired and the automatic manual switch is placed in the automatic position whereupon the machine ready light is lighted.
  • the automatic manual switch in the automatic position causes relay R13 to pick up, which in turn causes the motors and pilot lights of the timers ST] and ST2 to be energized.
  • the stepper switch S17 has been kept in the home position by relay R13, which energizes the step per reset magnet. At this time pushing the START/- SPIN button will cause the same circuit action as encountered in the MANUAL mode. Also, it will cause the stepper switch to step one position from its home position to step 1.
  • the clutch of the plugboard program spin timer is energized which starts the time spin interval.
  • the machine remains in the SPIN mode until the timer reaches the end of its preset travel. At the end of that interval that contacts in the timer operate which result in energizing relay R3, which starts the SUPERNATE OUT cycle. Energization and picking of relay R3 releases relay R2, which then resets the spin timer.
  • the machine will remain in the AGITATE mode until the pump reaches its home position at which time activation of the home limit switch will energize relay R1.
  • Relay R1 will energize relay R2 and this relay establishes the SPIN mode and steps the stepper switch to position 2. Subsequent events are the same as those described above until the stepper switch reaches the programmed stop position. If a stop is not programmed by suitable wiring on the plugboard, the stepper will continue to advance to the final step or step 10 and then will stop at the end of the next speed sense relay operation.
  • a programmed stop routes the signal that otherwise would be going to one of the wash solenoids to a pick up circuit for relay R12.
  • Relay R12 also activates the stepper reset solenoid resetting the stepper to home and finishing one complete sequence.
  • the HOLD condition can be initiated during any step in the AUTOMATIC cycle.
  • the HOLD circuit will stop the spin timer while the rest of the action is as described previously for manual operation. With the timer stopped, the machine will remain in spin until the CONTINUE button is pressed. This will restart the timer and the machine sequence will continue.
  • the HOLD condition acts exactly the same as in manual operation. With the pump stopped, however, the machine will remain in the SUPERNATE OUT mode because the pump cannot activate the end-of-travel switch or interface detector. Pressing the CONTINUE button will start the pump again.
  • the operation of the HOLD button will act as described for manual operation again because the hydraulic pump stops and can be restarted by operation of the CONTINUE button.
  • the safety interlock circuit includes two magnetically-operated reed switches under the rear of the sliding covers over the centrifuge well. This is to assure that the covers are closed before the centrifuge can rotate. With the covers open, the reed switches are open and relay R14 is tie-energized. Under these conditions the power is interrupted to the ready light and to the START/SPIN switch. When the covers are closed, relay R14 is energized, the ready light is lighted and the START/SPIN switch is powered. If during operation of the machine the covers are accidentally opened, relay R14 drops and momentarily picks relay R12 through the action of a charge stored on a large capacitor Q1. The momentary picking of relay R12 will initiate a stop operation and force the machine to stop.
  • relay R4 may be energized to initiate an AGITATE mode by the energization of a relay IFR.
  • This relay is governed by the circuitry shown in FIG. 11 of the drawings.
  • the reference character 101 indicates the transparent flexible tubing which carries the blood cells and supernatant to and from the blood bag in the centrifuge.
  • a light source 103 with a sensitivity control of 105 is positioned on one side of the tube, and a suitable photocell or light detector 107 is located opposite the light source and arranged so that packed red blood cells pass between the light source and photocell.
  • the photocell spectral response is chose to allow the detection of the packed red blood cell interface which is in the vicinity of 7,000 to 7,500 angstroms. This particular response area was arrived at by a spectrophotometer testing of plasma, packed red blood cells and hemolyzed samples of blood.
  • the output of the photocell is supplied to an emitter follower stage 109 for the purpose of impedance matching, and thence to inverter 111. From the output of inverter 111, the signal is supplied to a second inverter 113 and the input of a single shot 115.
  • the purpose of the single shot is to compare, at the input of the next following stage which constitutes an and-invert circuit 117, at the end of the single shot time-out the single shot output and signal through the inverter. If the signals are the same, then the circuit 17 will supply an output to a relay driver circuit 119 which in turn will energize the winding of relay IFR. If the signals are different at the inputs to circuit 117, then no signal is fed to the reed relay driver. Accordingly, the circuit blanks out the effect of small slugs or packed red blood cells which interrupt the light to the photocell and prevents these minor interruptions from energizing the relay [PR and advancing the machine to AGITATE mode. Only when a relatively continuous amount of packed red blood cells interrupt the light beam, for a period longer than the time out period of the single shot, will the relay IFR be operated.
  • the present invention provides a highly improved, compact blood processing system for processing blood portions which have been frozen so as to remove the glycerol or other agents preparatory to use of blood in transfusions.
  • the system is arranged so that it cannot only be manually operated, but by suitable programming may be run automatically.
  • Various safety features are provided which insure the proper operation of the equipment to safeguard the operation, as well as to insure the proper sequencing in the processing of the blood.
  • a blood processing apparatus including a motordriven centrifuge having a flexible membrane therein under which fluid may be forced to alter the volume above the membrane, a collapsible blood bag adapted to fit in the centrifuge over said flexible membrane, rotatable seal means for connecting said blood bag to a tubing manifold, valve means for controlling the flow of fluids to and from said blood bag, and motor-driven control pump means for supplying or removing fluid from the space below said membrane, said system having a plurality of possible modes of operation during a cycle of operation, the combination with foregoing of control means for governing the operation of said apparatus comprising,
  • electrically interlocked control means for providing a sequence of output control signals corresponding to said modes of operation
  • automatic programming means effective to supply inputs to said interlocked control means in a predetermined sequence corresponding to the sequential operations of said manually operated switches
  • timing means settable to a plurality of different time intervals and providing an output signal at the end of the settable time interval following energization of the timing means
  • first circuit means connecting said timing means to said automatic programming means to energize said timing means at least one preselected point in the operating cycle of said system
  • second circuit means connecting said timing means to said interlocked control means to supply output signals to said control means to thereby initiate the next step in the operating cycle of said system.
  • first and second manually-settable motor speed control means for said centrifuge and said control pump respectively, whereby the speeds of said centrifuge and said pump may be set individually and variably by the operator.
  • motor control switching means for selectively connecting the motor for said centrifuge to said first motor speed control means or to said low voltage source.
  • motor speed sensing means connected to the motor of said centrifuge
  • circuit means governed by said speed sensing means for advancing the sequence of operation of said system in response to said centrifuge reaching a predetermined speed.
  • said speed sensing means comprising a relay selectively connected to the drive circuit of the motor of said centrifuge during dynamic braking of said motor.
  • packed blood cell detection means for detecting the presence of packed red blood cells in the tubing connected to said blood bag, and means governed by said detector for advancing the control means to the next successive mode of operation when and only when packed red blood cells are detected in said tubing.
  • a first fluid reservoir for maintaining fluid pressure near atmospheric pressure in the fluid system during spin operation
  • the further improvement comprising, a second fluid reservoir to allow the system to accom aid t tu h ld means comprising ll operated modate different size wash solutions at each step in hold switch means connected to said control means Said blOOd- Washing procedure. to maintain it in the status effective when said hold

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • External Artificial Organs (AREA)
  • Centrifugal Separators (AREA)
US00211194A 1971-12-23 1971-12-23 Blood processing control apparatus Expired - Lifetime US3737096A (en)

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US21119471A 1971-12-23 1971-12-23

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CA (1) CA990255A (fr)
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Also Published As

Publication number Publication date
FR2164621A1 (fr) 1973-08-03
GB1371678A (en) 1974-10-23
JPS5636943B2 (fr) 1981-08-27
JPS4871093A (fr) 1973-09-26
CA990255A (en) 1976-06-01
IT971134B (it) 1974-04-30
DE2254403A1 (de) 1973-07-12
FR2164621B1 (fr) 1975-06-20

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