GB1371678A - Blood processing apparatus - Google Patents

Blood processing apparatus

Info

Publication number
GB1371678A
GB1371678A GB5312272A GB5312272A GB1371678A GB 1371678 A GB1371678 A GB 1371678A GB 5312272 A GB5312272 A GB 5312272A GB 5312272 A GB5312272 A GB 5312272A GB 1371678 A GB1371678 A GB 1371678A
Authority
GB
United Kingdom
Prior art keywords
fluid
bowl
membrane
blood
valve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5312272A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
International Business Machines Corp
Original Assignee
International Business Machines Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by International Business Machines Corp filed Critical International Business Machines Corp
Publication of GB1371678A publication Critical patent/GB1371678A/en
Expired legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0442—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3692—Washing or rinsing blood or blood constituents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • A61M1/3698—Expressing processed fluid out from the turning rotor using another fluid compressing the treatment chamber; Variable volume rotors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/64—Containers with integrated suction means
    • A61M1/68—Containers incorporating a flexible member creating suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/025—Means for agitating or shaking blood containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0429—Red blood cells; Erythrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/1483—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags using flexible bags externally pressurised by fluid pressure

Abstract

1371678 Centrifugal separator INTERNATIONAL BUSINESS MACHINES CORP 17 Nov 1972 [23 Dec 1971] 53122/72 Heading B2P A blood processing apparatus, Figs. 1 and 2, comprises a centrifuge bowl 1, having a flexible membrane 7(15) therein under which fluid may be forced to alter the volume above the membrane; a collapsible blood bag 11, 13 adapted to fit in the centrifuge bowl above the membrane; a rotatable seal RS for connecting the blood bag to a tubing manifold; valves V 1 -V 4 for controlling the flow of fluids to and from the blood bag; a pump assembly HP(31-37), Fig. 4, for supplying and removing fluid from the space below the membrane; and a controller, Fig. 7, for a plurality of possible modes of operation during a cycle of operation comprising a plurality of manually operated switches, one for each mode of operation, electrically interlocked control means for providing a sequence of output control signals corresponding to each mode of operation, and automatic programming means effective to operate the interlocked control means in a predetermined sequence corresponding to a cycle of individual modes of operation. The apparatus is used for washing preservatives from thawed red blood cells with various solutions and resuspending the cells in isotonic solution, albumin or plasma in preparation for blood transfusion to a recipient. The disposable flexible bag is retained over bosses 23 in the bowl by a cover 21 which is held in position by hold-down screws which cooperate with a hole and slot arrangement in the cover. A tube 19 leads from the flexible bag to the tubing manifold connected via the valves V 1 , V 2 V 3 to various washing fluid receptacles 1, 2, 3 and via a valve V 4 to a waste receiver. Hydraulic fluid is admitted to, and removed from, the space below the membrane via the centrifuge hollow shaft 9 which communicates via a tubing 17 connected to the pump assembly HP and fluid reservoir HR (41) via valves such as V 5 . The centrifuge shaft is driven via belting . from a variable speed reversible electric motor and is supported in bearings 25, 27. The hydraulic control pump assembly HP comprises a pair of cylinders 31 with pistons tied by a yoke 33 which in turn is fastened to a rack 35 moved up and down by a pinion driven by a motor and gear assembly associated with suitable control circuitry whereby fluid may be forced into, or removed from, the bowl. A stepping switch 45 is uitilized in conjunction with a plugboard 43 by which varying operating programs may be arranged by the operator by connecting various jacks with suitable jumper wires. A relay mounting gate 47 is provided for mounting the various relays in the apparatus control circuit which is described in detail. In operation, the flexible bag is placed in the centrifuge bowl either already filled with the blood cell-preservative mixture or filled via the tubing 19 from a blood container connected via a valve to the tube manifold. The centrifuge bowl is spun so that the blood cell mixture is pressed against the outside wall of the bowl. A negative pressure results in the fluid system under the flexible membrane 7(15) and, with the valve V 5 open during spinning and the reservoir HP(41) connected to atmosphere, fluid is forced into the bowl until the latter is full. Valve V 5 is closed and fluid is pumped into the bowl by the control pump HP. The resulting expansion of the membrane forces supernatant solution to flow to the waste receiver through valve V 4 which is open at this time. The centrifuge bowl is then stopped and put into an agitation mode in which it revolves for a few cycles in alternate directions on a continuing basis and waste solution is supplied to the bag by opening a suitable one of valves V 1 , V 2 and V 3 and pumping hydraulic fluid out from under the membrane by the pump HP. During the agitation mode valve V 5 is open. This process is repeated as many times as desired and the operation of the entire system is variably controlled either by manual control or through the internal programming of the system.
GB5312272A 1971-12-23 1972-11-17 Blood processing apparatus Expired GB1371678A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21119471A 1971-12-23 1971-12-23

Publications (1)

Publication Number Publication Date
GB1371678A true GB1371678A (en) 1974-10-23

Family

ID=22785925

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5312272A Expired GB1371678A (en) 1971-12-23 1972-11-17 Blood processing apparatus

Country Status (7)

Country Link
US (1) US3737096A (en)
JP (1) JPS5636943B2 (en)
CA (1) CA990255A (en)
DE (1) DE2254403A1 (en)
FR (1) FR2164621B1 (en)
GB (1) GB1371678A (en)
IT (1) IT971134B (en)

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Also Published As

Publication number Publication date
FR2164621A1 (en) 1973-08-03
FR2164621B1 (en) 1975-06-20
CA990255A (en) 1976-06-01
JPS4871093A (en) 1973-09-26
US3737096A (en) 1973-06-05
JPS5636943B2 (en) 1981-08-27
IT971134B (en) 1974-04-30
DE2254403A1 (en) 1973-07-12

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PE20 Patent expired after termination of 20 years