US3717174A - Perfusion safety valve - Google Patents

Perfusion safety valve Download PDF

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Publication number
US3717174A
US3717174A US3717174DA US3717174A US 3717174 A US3717174 A US 3717174A US 3717174D A US3717174D A US 3717174DA US 3717174 A US3717174 A US 3717174A
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Prior art keywords
blood
tube
closed space
membrane wall
valve
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Expired - Lifetime
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English (en)
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R Dewall
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/36—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests with means for eliminating or preventing injection or infusion of air into body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/227—Valves actuated by a secondary fluid, e.g. hydraulically or pneumatically actuated valves
    • A61M39/228—Valves actuated by a secondary fluid, e.g. hydraulically or pneumatically actuated valves with a tubular diaphragm constrictable by radial fluid force
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/7722—Line condition change responsive valves
    • Y10T137/7837—Direct response valves [i.e., check valve type]
    • Y10T137/7879—Resilient material valve
    • Y10T137/788—Having expansible port
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/85978—With pump
    • Y10T137/85986—Pumped fluid control
    • Y10T137/86002—Fluid pressure responsive
    • Y10T137/86019—Direct response valve

Definitions

  • Patent 1 Dewall [54] PERFUSION SAFETY VALVE [76] Inventor: Richard A. Dewall, 247 Northview Rd., Dayton, Ohio 45419 [22] Filed: Aug. 3, 1971 [211 Appl. No.: 168,642
  • ABSTRACT A perfusion safety valve for use in blood oxygenating systems.
  • the valve includes an elongated, rigid, perforated tube and interiorly disposed therein is a collapsible membrane-like wall which may collapse to cut off the flow of blood through the tube.
  • Exteriorly of the tube is a second membrane-like wall and the space between the two membrane walls is filled with a liquid.
  • the liquid will pass through the perforations of the tube into the interior of the tube to cause collapse of the interior wall to shut off the flow through the valve to preclude the pumping of air into the arterial system of a patient using the oxygenating system.
  • the exemplary embodiment of the invention achieves the foregoing objects by means of a construction employing an elongated, perforated, rigid tube. About the entire inner periphery of the tube there is provided a flexible, blood compatible membrane, while exteriorly of the tube, a generally similar membrane is provided. The two membranes are arranged with respect to each other and to the tube such that the closed space between the two membranes having a volume at least slightly greater than the volume of the interior of the tube results. The close space is filled with a biologically harmless liquid such as a saline solution.
  • the typical positive displacement pump for the blood line is located downstream of the valve, and the valve is located downstream of an oxygenator or the like.
  • the head of the blood in the oxygenator will be sufficient to maintain the inner membrane in substantial abutment with the interior wall of the tube so that blood may flow therethrough.
  • the slight vacuum pulled by the pump will result in atmospheric pressure being applied to the outer membrane forcing the liquid in the closed space through the perforations into the tube to the interface between the interior of the tube and the inner membrane thereby causing the latter to collapse upon itself to terminate the flow of fluid through the line.
  • the construction requires no operating components other than the positive displacement pump used in the oxygenating system itself and should the same fail, it will be obvious that there would be no chance of air embolism by reason of the ceasing of the pumping action.
  • exterior equipment might be employed to control the valve position which equipment could fail while the pump continued in operation, in which case, the valve would be ineffective.
  • barbed tubular extensions are secured to opposite ends of the tube for connection into typical plastic blood conduit tubing employed in such systems.
  • FIG. 1 is a flow diagram illustrating a typical oxygenating system with which the inventive valve is designed to be employed;
  • FIG. 2 is a sectional view of a valve made according to the invention showing the component parts when the valve is open;
  • FIG. 3 is a sectional view of the valve in a closed condition
  • FIG. 4 is a cross section of the valve in an open condition
  • FIG. 5 is a cross section of the valve in a closed condition.
  • FIG. 1 One typical system in which a valve made according to the invention is intended to be used is illustrated in schematic form in FIG. 1 and is seen to include a conventional blood oxygenator 10 adapted to receive venous blood from a patient 12. Downstream of the oxygenator 10, and physically below the oxygenator is a perfusion safety valve, generally designated 14, so that a head of blood is applied thereto. Downstream of the valve 14 is a positive displacement pump 16 which, in turn, provides oxygenated blood to the arterial system of the patient. As will be seen, the physical location of the valve 14 with respect to the oxygenator 10 is of some significance insofar as the valve in part responds to the lack of establishment of a predetermined head of blood applied thereto. This factor, coupled with the slight vacuum pulled by the positive displacement pump 16, will cause the valve 14 to close if the blood in the oxygenator reservoir 10 becomes exhausted.
  • the valve 14 comprises an elongated, rigid tube 18 which may be formed of polycarbonate, methacrylate or similar plastic.
  • the tube 18 is perforated as at 20 (additional perforations 20 may be located along virtually the entire length of the tube 18, if desired) and includes internal steps 22 at its ends.
  • a circumferential membrane film 24 defining a blood impermeable wall.
  • the membrane 24 is sufficiently flexible so that the same may collapse upon itself within the interior of the tube to cut off the flow of fluid therethrough and is formed of any suitable blood compatible material such as silicone rubber or a polyvinyl plastic.
  • a second peripheral membrane film 26 Exteriorly of the tube 18 is a second peripheral membrane film 26, also formed of any suitable flexible material.
  • the membranes 24 and 26 define a closed space 28 having a volume at least slightly greater than the volume of the interior of the tube 18 between the ends of the membranes 24 and 26 (and in the embodiment illustrated in FIGS. 2 and 3, the ends of the tube 18) and which is adapted to receive biologically harmless liquid such as a saline solution.
  • the outer film 26 may be provided with a suitable sealable port (not shown) for the purpose of introducing a liquid into the closed space 28.
  • the ends of the membrane 26 are sealingly secured to the ends of the tube 18 in any suitable fashion to partially define the closed space 28 while the ends of the membrane 24 may be received in the steps 22 of the tube 18.
  • any suitable means such as an adhesive may be employed or, in the alternative, for the two-fold purpose of establishing sealing engagement between the membrane 24 and the tube 18 and to facilitate connec tion of the latter into blood conduit tubing
  • tubular extensions 30 having complementary steps 32 may be received in the steps 22 and secured thereto to sealingly hold the ends of the membrane 24 thereagainst.
  • the extensions 30 include barbed ends 34 for receipt into conventional plastic tubing employed in the blood line.
  • a suitable conduit from the oxygenator will be secured to one of the barbed extensions 30 while the conduit to the pump 16 will be secured to the other barbed extension 30.
  • the pressure of the same will maintain the membrane 24 in the position illustrated in FIGS. 2 and 4 so that blood may pass through the valve 14 to the pump 16 and then to the patient 12.
  • the slight vacuum pulled by the pump will result in the atmospheric pressure applied to the outer membrane 26 collapsing the same driving the saline solution within the closed space 28 through the perforations to force the inner membrane 24 to seal upon itself as illustrated in FIGS. 3 and 5 to halt the flow of fluid through the line while at least a minimal quantity of blood remains therein to preclude any possibility of air embolism.
  • the internal diameter of the tube 18 is about three-eighths of an inch while the length of the surface of the inner membrane 24 that may collapse upon itself will be at least ten times that length so that the capability of sealing upon collapse is enhanced. For a typical construction, this would require a length on the order of 4 to 6 inches.
  • a valve made according to the invention does not require operating equipment other than that found in the oxygenating system itself so that system failure cannot be occasioned by failure of peripheral equipment.
  • the simplicity of construction coupled with positive action results in an inexpensive construction that is completely reliable and one which may be disposed of after a single use.
  • a blood oxygenating system including a perfusion safety valve comprising an elongated, relatively rigid, perforated tube; means at each end of said tube for connecting the same into a conduit in which blood is flowing; a peripheral inner membrane wall formed of a flexible material compatible with blood within said tube; an outer membrane wall outside of said tube; said inner and outer membrane walls defining a closed space; and a liquid within said closed space; whereby when blood is flowing through said tube, said inner membrane wall will be in substantial abutment with the internal surface of said tube while when blood ceases to flow to said tube, a slight vacuum in the blood line will cause the liquid in said closed space to flow through the perforations in said tube to cause said inner membrane wall to collapse upon itself to seal off the blood line, a blood oxygenator adapted to receive blood from a patient for oxygenating the same; means establishing a blood flow path from said oxygenator to one of said connecting means; a blood pump; means establishing a blood flow path from the other of said connecting means to said blood pump, said blood pump being
  • said inner membrane wall has a length equal to about at least ten times the cross sectional dimension of "said tube; said closed space has a volume at least slightly greater than the volume of the interior of said tube along the length of the inner membrane wall; and the liquid in said closed space is a biologically harmless liquid.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • External Artificial Organs (AREA)
US3717174D 1971-08-03 1971-08-03 Perfusion safety valve Expired - Lifetime US3717174A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16864271A 1971-08-03 1971-08-03

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US3717174A true US3717174A (en) 1973-02-20

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US (1) US3717174A (enExample)
CA (1) CA999499A (enExample)
DE (1) DE2237858A1 (enExample)
FR (1) FR2148219B1 (enExample)
GB (1) GB1399501A (enExample)
IT (1) IT961755B (enExample)

Cited By (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833013A (en) * 1972-04-06 1974-09-03 Baxter Laboratories Inc Self-valving fluid reservoir and bubble trap
US3849071A (en) * 1972-12-21 1974-11-19 K Kayser Blood-gas separating system for perfusate circulation
US3889648A (en) * 1972-04-04 1975-06-17 Cav Ltd Fuel systems for engines
US3907504A (en) * 1973-04-06 1975-09-23 Gen Electric Blood oxygenation system including automatic means for stabilizing the flow rate of blood therethrough
US3927980A (en) * 1973-08-22 1975-12-23 Baxter Laboratories Inc Oxygen overpressure protection system for membrane-type blood oxygenators
US3991768A (en) * 1973-03-16 1976-11-16 Portnoy Harold D Shunt system resistant to overdrainage and siphoning and valve therefor
US4131431A (en) * 1976-12-27 1978-12-26 Siposs George G Blood shut-off valve
US4140635A (en) * 1977-04-13 1979-02-20 Esmond William G Purification device
EP0045668A1 (en) * 1980-08-06 1982-02-10 Peter Steer Developments Limited Device for controlling the flow of liquid
US4515589A (en) * 1981-03-23 1985-05-07 Austin Jon W Peristaltic pumping method and apparatus
US4527588A (en) * 1983-12-14 1985-07-09 Warner-Lambert Company Safety valve
DE3420861A1 (de) * 1984-06-05 1985-12-05 Biotest Pharma GmbH, 6000 Frankfurt Schlauchpumpe fuer medizinische zwecke
WO1987004079A1 (en) * 1986-01-13 1987-07-16 Sawyer Philip Nicholas Methods for preventing the introduction of air or fluid reflux into the body of a patient
US4684364A (en) * 1983-04-12 1987-08-04 Interface Biomedical Laboratories Corporation Safety arrangement for preventing air embolism during intravenous procedures
US4722725A (en) * 1983-04-12 1988-02-02 Interface Biomedical Laboratories, Inc. Methods for preventing the introduction of air or fluid into the body of a patient
US4877025A (en) * 1988-10-06 1989-10-31 Hanson Donald W Tracheostomy tube valve apparatus
US4883461A (en) * 1987-05-15 1989-11-28 Interface Biomedical Laboratories Corp. Safety needle sheath in anti-reflux catheter having novel valve means
US5152964A (en) * 1988-12-14 1992-10-06 Minnesota Mining And Manufacturing Company Membrane blood oxygenator
US5161773A (en) * 1990-08-01 1992-11-10 Numed, Inc. Method and apparatus for controlling fluid flow
US5186431A (en) * 1989-09-22 1993-02-16 Yehuda Tamari Pressure sensitive valves for extracorporeal circuits
US5378299A (en) * 1991-05-20 1995-01-03 M & D Balloons, Inc. Method of making a balloon with flat film valve
US5382407A (en) * 1988-12-14 1995-01-17 Minnesota Mining And Manufacturing Company Membrane blood oxygenator
US5482492A (en) * 1994-01-10 1996-01-09 M & D Balloons, Inc. Balloons and balloon valves
EP0701834A1 (fr) * 1994-09-16 1996-03-20 Georges Boussignac Dispositif d'assistance respiratoire
US20040054348A1 (en) * 2002-09-12 2004-03-18 Michael Hogendijk Catheter having a compliant member configured to regulate aspiration rates
US20040073174A1 (en) * 1991-12-18 2004-04-15 Lopez George A. Medical valve and method of use
US20060200086A1 (en) * 1995-12-15 2006-09-07 Lopez George A Medical valve with fluid escape space
US20080029173A1 (en) * 2006-08-07 2008-02-07 Diperna Paul Mario Variable flow reshapable flow restrictor apparatus and related methods
US20080196762A1 (en) * 2002-07-19 2008-08-21 Scott Mallett Systems and methods for the accurate delivery of flow materials
US20090217982A1 (en) * 2008-02-28 2009-09-03 Phluid Inc. Adjustable flow controllers for real-time modulation of flow rate
US20100032041A1 (en) * 2008-08-08 2010-02-11 Tandem Diabetes Care, Inc. System of stepped flow rate regulation using compressible members
US20100065578A1 (en) * 2008-09-16 2010-03-18 Diperna Paul M Flow regulating stopcocks and related methods
USD644731S1 (en) 2010-03-23 2011-09-06 Icu Medical, Inc. Medical connector
US8034065B2 (en) * 2008-02-26 2011-10-11 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US8105314B2 (en) 2006-10-25 2012-01-31 Icu Medical, Inc. Medical connector
US8287495B2 (en) 2009-07-30 2012-10-16 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8444628B2 (en) 2000-07-11 2013-05-21 Icu Medical, Inc. Needleless medical connector
US8454579B2 (en) 2009-03-25 2013-06-04 Icu Medical, Inc. Medical connector with automatic valves and volume regulator
US20130296783A1 (en) * 2010-06-14 2013-11-07 University Of Manitoba Method and apparatus for retroperfusion
US8650937B2 (en) 2008-09-19 2014-02-18 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
US8758306B2 (en) 2010-05-17 2014-06-24 Icu Medical, Inc. Medical connectors and methods of use
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US9186494B2 (en) 2004-11-05 2015-11-17 Icu Medical, Inc. Medical connector
USD786427S1 (en) 2014-12-03 2017-05-09 Icu Medical, Inc. Fluid manifold
USD793551S1 (en) 2014-12-03 2017-08-01 Icu Medical, Inc. Fluid manifold
US9962486B2 (en) 2013-03-14 2018-05-08 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US10258736B2 (en) 2012-05-17 2019-04-16 Tandem Diabetes Care, Inc. Systems including vial adapter for fluid transfer
US10369349B2 (en) 2013-12-11 2019-08-06 Icu Medical, Inc. Medical fluid manifold
US20210369998A1 (en) * 2020-05-28 2021-12-02 Xuanwu Hospital Capital Medical University Cannula plugging device for rehabilitation after tracheotomy
US12539364B2 (en) 2024-05-20 2026-02-03 Tandem Diabetes Care, Inc. Infusion pump systems with disposable cartridge having pressure venting and pressure feedback

Families Citing this family (2)

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AU576806B2 (en) * 1983-12-28 1988-09-08 Sweepy International S.A. Diaphragm valve assembly for pool cleaner
CN111043348A (zh) * 2019-12-18 2020-04-21 武汉圣禹排水系统有限公司 带有安装结构的橡胶套筒及安装该套筒的管道

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US3183908A (en) * 1961-09-18 1965-05-18 Samuel C Collins Pump oxygenator system
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US2572658A (en) * 1948-02-16 1951-10-23 Albert G Perkins Automatic teat cup release device for milking machines
US2756959A (en) * 1951-07-25 1956-07-31 Globe Company Fluid-pressure responsive sphincter valve
US2964285A (en) * 1958-09-09 1960-12-13 Soc D Ciments De Marseille Et Direct-passage valve
US2982511A (en) * 1959-02-27 1961-05-02 Douglas M Connor Pressure-operated control valve
US3204631A (en) * 1961-05-01 1965-09-07 Louis G Fields Blood oxygenator and pump apparatus
US3183908A (en) * 1961-09-18 1965-05-18 Samuel C Collins Pump oxygenator system
US3513845A (en) * 1966-09-15 1970-05-26 United Aircraft Corp Bypass heart pump and oxygenator system

Cited By (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3889648A (en) * 1972-04-04 1975-06-17 Cav Ltd Fuel systems for engines
US3833013A (en) * 1972-04-06 1974-09-03 Baxter Laboratories Inc Self-valving fluid reservoir and bubble trap
US3849071A (en) * 1972-12-21 1974-11-19 K Kayser Blood-gas separating system for perfusate circulation
US3991768A (en) * 1973-03-16 1976-11-16 Portnoy Harold D Shunt system resistant to overdrainage and siphoning and valve therefor
US3907504A (en) * 1973-04-06 1975-09-23 Gen Electric Blood oxygenation system including automatic means for stabilizing the flow rate of blood therethrough
US3927980A (en) * 1973-08-22 1975-12-23 Baxter Laboratories Inc Oxygen overpressure protection system for membrane-type blood oxygenators
US4131431A (en) * 1976-12-27 1978-12-26 Siposs George G Blood shut-off valve
US4140635A (en) * 1977-04-13 1979-02-20 Esmond William G Purification device
EP0045668A1 (en) * 1980-08-06 1982-02-10 Peter Steer Developments Limited Device for controlling the flow of liquid
US4515589A (en) * 1981-03-23 1985-05-07 Austin Jon W Peristaltic pumping method and apparatus
US4684364A (en) * 1983-04-12 1987-08-04 Interface Biomedical Laboratories Corporation Safety arrangement for preventing air embolism during intravenous procedures
US4722725A (en) * 1983-04-12 1988-02-02 Interface Biomedical Laboratories, Inc. Methods for preventing the introduction of air or fluid into the body of a patient
US4527588A (en) * 1983-12-14 1985-07-09 Warner-Lambert Company Safety valve
DE3420861A1 (de) * 1984-06-05 1985-12-05 Biotest Pharma GmbH, 6000 Frankfurt Schlauchpumpe fuer medizinische zwecke
WO1987004079A1 (en) * 1986-01-13 1987-07-16 Sawyer Philip Nicholas Methods for preventing the introduction of air or fluid reflux into the body of a patient
US4883461A (en) * 1987-05-15 1989-11-28 Interface Biomedical Laboratories Corp. Safety needle sheath in anti-reflux catheter having novel valve means
US4877025A (en) * 1988-10-06 1989-10-31 Hanson Donald W Tracheostomy tube valve apparatus
US5152964A (en) * 1988-12-14 1992-10-06 Minnesota Mining And Manufacturing Company Membrane blood oxygenator
US5382407A (en) * 1988-12-14 1995-01-17 Minnesota Mining And Manufacturing Company Membrane blood oxygenator
US5186431A (en) * 1989-09-22 1993-02-16 Yehuda Tamari Pressure sensitive valves for extracorporeal circuits
US5305982A (en) * 1989-09-22 1994-04-26 Yehuda Tamari Adjustable static pressure regulator
US5161773A (en) * 1990-08-01 1992-11-10 Numed, Inc. Method and apparatus for controlling fluid flow
US5378299A (en) * 1991-05-20 1995-01-03 M & D Balloons, Inc. Method of making a balloon with flat film valve
US7717886B2 (en) 1991-12-18 2010-05-18 Icu Medical, Inc. Medical valve and method of use
US20040073174A1 (en) * 1991-12-18 2004-04-15 Lopez George A. Medical valve and method of use
US7713247B2 (en) 1991-12-18 2010-05-11 Icu Medical, Inc. Medical valve and method of use
US7713248B2 (en) 1991-12-18 2010-05-11 Icu Medical, Inc. Medical valve and method of use
US7717884B2 (en) 1991-12-18 2010-05-18 Icu Medical, Inc. Medical valve and method of use
US7717887B2 (en) 1991-12-18 2010-05-18 Icu Medical, Inc. Medical valve and method of use
US7713249B2 (en) 1991-12-18 2010-05-11 Icu Medical, Inc. Medical valve and method of use
US7717883B2 (en) 1991-12-18 2010-05-18 Icu Medical, Inc. Medical valve and method of use
US7722575B2 (en) 1991-12-18 2010-05-25 Icu Medical, Inc. Medical valve and method of use
US20040243070A1 (en) * 1991-12-18 2004-12-02 Lopez George A. Medical valve and method of use
US7722576B2 (en) 1991-12-18 2010-05-25 Icu Medical, Inc. Medical valve and method of use
US7717885B2 (en) 1991-12-18 2010-05-18 Icu Medical, Inc. Medical valve and method of use
US20060206058A1 (en) * 1991-12-18 2006-09-14 Lopez George A Medical valve and method of use
US20060264845A1 (en) * 1991-12-18 2006-11-23 Icu Medical, Inc. Medical valve and method of use
US20060264892A1 (en) * 1991-12-18 2006-11-23 Icu Medical, Inc. Medical valve and method of use
WO1993018324A1 (en) * 1992-03-13 1993-09-16 Yehuda Tamari Pressure sensitive devices for extracorporeal pumping
US5482492A (en) * 1994-01-10 1996-01-09 M & D Balloons, Inc. Balloons and balloon valves
US5595521A (en) * 1994-01-10 1997-01-21 M & D Balloons, Inc. Balloons and balloon valves
US5538002A (en) * 1994-09-14 1996-07-23 Boussignac; Georges Device for respiratory assistance
FR2724564A1 (fr) * 1994-09-16 1996-03-22 Boussignac Georges Dispositif d'assistance respiratoire
EP0701834A1 (fr) * 1994-09-16 1996-03-20 Georges Boussignac Dispositif d'assistance respiratoire
US20060200086A1 (en) * 1995-12-15 2006-09-07 Lopez George A Medical valve with fluid escape space
US8002765B2 (en) 1995-12-15 2011-08-23 Icu Medical, Inc. Medical valve with fluid escape space
US9238129B2 (en) 2000-07-11 2016-01-19 Icu Medical, Inc. Medical connector
US8444628B2 (en) 2000-07-11 2013-05-21 Icu Medical, Inc. Needleless medical connector
US8870850B2 (en) 2000-07-11 2014-10-28 Icu Medical, Inc. Medical connector
US20080196762A1 (en) * 2002-07-19 2008-08-21 Scott Mallett Systems and methods for the accurate delivery of flow materials
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Also Published As

Publication number Publication date
CA999499A (en) 1976-11-09
DE2237858A1 (de) 1973-02-15
GB1399501A (en) 1975-07-02
FR2148219A1 (enExample) 1973-03-16
IT961755B (it) 1973-12-10
FR2148219B1 (enExample) 1975-03-07

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