US3674031A - Method of and device for cryogenic surgery - Google Patents
Method of and device for cryogenic surgery Download PDFInfo
- Publication number
- US3674031A US3674031A US23165A US3674031DA US3674031A US 3674031 A US3674031 A US 3674031A US 23165 A US23165 A US 23165A US 3674031D A US3674031D A US 3674031DA US 3674031 A US3674031 A US 3674031A
- Authority
- US
- United States
- Prior art keywords
- tissue
- concavity
- wall
- shell
- cell tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/30—Surgical pincettes without pivotal connections
- A61B2017/306—Surgical pincettes without pivotal connections holding by means of suction
Definitions
- cryogenic devices for a rapidly expanding branch of surgery referred to as "cryosurgery or low-temperature surgery.
- a low-temperature fluid e.g., liquid nitrogen
- a probe or like structure which is applied to the tissue to be treated or removed, thereby abstracting heat rapidly from this tissue and destroying the tissue structure so that the 2 thereof with minimum damage to the vascular system adjoining such tissues.
- cryogenic probes have been proposed to make use of such cryogenic probes in tonsillectomies which heretofore have required local anesthetic and enucleation or extirpation of the cellular tissue with prolonged convalescence and bed rest. Furthermore, the conventional operation was bloody and could not be carried out effectively with patients in whom loss of blood might lead to other complications.
- the use of the cryogenic probe eliminated these difficulties by permitting removal of the tonsil follicles without bleeding and while the patient remains ambulatory.
- the tonsils may be wholly or partly removed upon necrosis resulting from contact with the cryogenic probe.
- Anotherobject of this invention is to provide an improved apparatus or device for the removal of cellular tissue, especially mammalian tissue, without excessive damage to sur workers in the field with minimum danger of complications and maximum effectiveness for the removal of tonsils and like cellular tissue.
- a concave shellat the end of the cryogenic instrument which may be placed over the area to be subjected to cryogenic surgery and communicating with a suction source while being provided with means for cooling the wall of this cell externally of the concavity.
- the present system thus includes a suction device for drawing'the cellular tissue into the concavity concurrently with the cryogenic freezing of this tisue by heat transferthrough the wall of the cavity of a cryogenic fluid in contact with this wall.
- the cooling system may includemeans for circulating a coolant through the'instrument or merely designed to deliver a coolant to the surface whereupon the coolant may be discharged.
- the suction action in accordance'with the present invention makes use of a cavity which is preferably dimensioned to the volume of the cellular tissue. to be affected by cryogenic surgery,i.e;, the volumeof the tissue to b'e-removed. It hasbeen found, most surprisingly, that by drawing the removabletissue out of its normal position, e.g., by distorting'the'tissueinto the concavity, it is possible to transfer cold to this limited volume resides in the convergence of the cold upon'the cellular tissue drawn into the concavity and the exclusion of adjacent tissue from-cryogenic attack. When the system is applied to tonsillectomies, therefore, the cryogenic attack and removal is limited to the tonsil follicles without any danger of adversely affecting the vascular system communicating blood to and from the head.
- the instrument according to the invention is advantageously provided with a hollow body open at one end and constituting a shell, the outer rim of which is bent outis preferably composed of a material having a high'coefi'icient' of heat transfer, advantageously a metal which is-inert and may be of the type commonly employed in surgical instruments: silver, stainless steel or the like. It has been found to be advantageous, moreover, to provide the concavity with a ratio of depth-to-mouth diameter between 1:10 and 1:1 and to provide a wall thickness which is of the order of millimeter and is in a ratio to the depth of the cavity between 1:2 and 1:10.
- the hollow shell is of double-wall construction, i.e., is formed with a compartment extending along the outer wall of the concavity and constituting a cooling compartrnent and a handle may be provided in the form of a coaxial-tube arrangement one tube of which serves to deliver the coolant while the other carries it away from this chamber.
- the inner tube which may be of relatively small diameter, supplies cryogenic liquid which expands into the chamber and passes through the outer tube as a vapor or gas.
- the present invention while finding its most significant application in cryogenic surgery and in the treatment of human cellular tissue is also suitable for use in biology and veterinary medicine in general. In fact, wherever more or less flexible materials are to be cryogenically treated, the instrument of the present invention finds application.
- FIG. 1 is an axial cross-sectional view schematically illus trating the principles of the present invention
- FIG. 2 is a sectional view similar to FIG. 1 showing the instrument in operation
- FIG. 3 is a further sectional view of a preferred embodiment of the invention.
- FIGS. 1 .and 2 I have shown a device for performing tonsillectomies'but which is suitable for other cryogenic operations and substantially any treatment of relatively soft matter with cold.
- the device comprises a thin-walled metal cup 1 having a shell configuration and formed with a concavity In which is open against the tissue portion 2 to be treated with cold.
- the depth d of the concavity can be a fraction of the mouth diameter D or may equal or exceed this diameter as shown in FIG. 3 and as described above.
- the mouth lb of the shell 1 is formed with an outwardly turned and rounded rim 1c which defines a radius portion 1d at the annulus with which the instrument contacts the tissue 2. The radius 1d prevents tearing of the tissue when the latter is drawn by suction into the concavity la.
- an orifice 1 which communicates between the concavity la and a tube 3 formed unitarily with the wall 2 and serving to apply suction to the concavity, e.g., via a suction pump or aspirator 3a.
- FIG. 2 I have shown the instrument of FIG. 1 in opera tion. Suction applied to the bore 3b of tube 3 reduces the pressure within the concavity la, thereby drawing the tissue body 2b surrounded within the annulus 1b into the concavity and into contact with the inner surface thereof.
- a cryogenic cooling medium e. g., nitrogen, passes the outer surface 1b of the shell 1 as represented at 4, thereby cooling the shell which lies in heat conductive relationship to the bulge 2b of tissue received within the concavity.
- the cold transfer is represented diagrammatically by the arrows in FIG. 2 and appears to converge to a center close to the center of curvature of the inner wall of the concavity.
- the shell 8 is substantially hemispherical and is formed as a double wall or socket body, the outer wall of which is represented at 7.
- the walls are formed unitarily with one another and adjoin at the rounded rim 8a defining an annulus contacting the tissue surface 2.
- the inner chamber 9 of the hollow-wall body 5 is a cooling compartment to which the coolant supplies via a passage 10a in an inner duct leading from a refrigerating system or liquid nitrogen tank 10b to the interior of the compartment 9.
- the tube 10 is coaxially surrounded by 'a tube 11, also unitary with'a hollow body 5, and defining a passage 11a of greater cross section than the passage 10a. Consequently a liquid coolant (generally liquid nitrogen) passes through the narrow bore 10a and expands in the chamber 9 with the formed gases emerging via the passage 11:: for recycling or release.
- the coaxial tubes wand 11 or the tube 6 may constitute a handle or may be mounted in a handle to facilitate manipulation of the device by the surgeon.
- the tube 6, whose bore 60 opens into an orifice 6b at the apex of the concavity 8b, is connected to a suction pump 6c as described with reference to the embodiment of FIGS. 1 and 2.
- the device of FIG. 3 operates identically to the device of FIGS. 1 and 2 I claim:
- a method of cold-treating soft material comprising the 7 steps of juxtaposing with a body of cell tissue, a rigid thermally conductive metal shell concave in the direction of said cell tissue; evacuating'said shell to draw a portion of said cell tissue said method further comprising the step of withdrawing said shell from said body while maintaining suction in said concavity subsequent to the transfer of cold to said portion of said material.
- An instrument for cryogenic surgery upon mammalian cell tissue comprising:
- a rigid metal cup mounted on an end of said handle and having a concavity adapted to be applied to said tissue, said cup being formed .with a pair of spaced-apart walls def'ming an interwall compartment and including an inner wall and an outer wall;
- conduit means connected to said cup and communicating with said concavity
- a suction pump connected to said conduit means for evacuating said concavity and drawing said tissue against the inner wall.
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- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Manufacture And Refinement Of Metals (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19691916343 DE1916343C (de) | 1969-03-29 | Vorrichtung für die Chirurgie an menschlichem Zellgewebe, insbesondere Mandelgewebe |
Publications (1)
Publication Number | Publication Date |
---|---|
US3674031A true US3674031A (en) | 1972-07-04 |
Family
ID=5729824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US23165A Expired - Lifetime US3674031A (en) | 1969-03-29 | 1970-03-25 | Method of and device for cryogenic surgery |
Country Status (5)
Country | Link |
---|---|
US (1) | US3674031A (sv) |
JP (1) | JPS5231674B1 (sv) |
CH (1) | CH522397A (sv) |
FR (1) | FR2040113A5 (sv) |
GB (1) | GB1271881A (sv) |
Cited By (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3794039A (en) * | 1969-10-25 | 1974-02-26 | Linde Ag | Apparatus for cryosurgery |
US3862627A (en) * | 1973-08-16 | 1975-01-28 | Sr Wendel J Hans | Suction electrode |
US3926006A (en) * | 1973-04-09 | 1975-12-16 | Cap Con International Inc | Method and apparatus of freezing a plug in a pipe for pressure testing |
US3934589A (en) * | 1973-05-26 | 1976-01-27 | Dragerwerk Aktiengesellschaft | Surgical instrument for sterilizing women by ligature of tubes |
US4072152A (en) * | 1976-02-23 | 1978-02-07 | Linehan John H | Orthopedic cryosurgical apparatus |
US4082096A (en) * | 1973-12-10 | 1978-04-04 | Benson Jerrel W | Cryosurgical system |
US4135497A (en) * | 1977-03-18 | 1979-01-23 | E-Z-Em Company, Inc. | Apparatus for detecting temperature variations over selected regions of living tissue, and method thereof |
USRE30446E (en) * | 1979-03-16 | 1980-12-16 | E-Z-Em Company, Inc. | Apparatus for detecting temperature variations over selected regions of living tissue, and method thereof |
US4327733A (en) * | 1981-01-28 | 1982-05-04 | Governing Council Of The University Of Toronto | Cryoenucleation tool |
US4440167A (en) * | 1980-12-26 | 1984-04-03 | Kabushikikaisha Yoshida | Anesthetizer for dental treatment |
US5034006A (en) * | 1987-06-22 | 1991-07-23 | Takeda Chemical Industries, Ltd. | Suction equipment for medical operation |
US5271234A (en) * | 1992-12-18 | 1993-12-21 | David L. Carter | Apparatus for and method of removing tile from a floor |
US5433717A (en) * | 1993-03-23 | 1995-07-18 | The Regents Of The University Of California | Magnetic resonance imaging assisted cryosurgery |
US6148619A (en) * | 1999-08-17 | 2000-11-21 | Evans; Daniel J. | Method and apparatus for non-invasively freezing a content of a pipe |
US6482226B1 (en) | 1998-01-23 | 2002-11-19 | Innercool Therapies, Inc. | Selective organ hypothermia method and apparatus |
US6491039B1 (en) | 1998-01-23 | 2002-12-10 | Innercool Therapies, Inc. | Medical procedure |
US6558412B2 (en) | 1998-01-23 | 2003-05-06 | Innercool Therapies, Inc. | Selective organ hypothermia method and apparatus |
US6602276B2 (en) | 1998-03-31 | 2003-08-05 | Innercool Therapies, Inc. | Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation |
US6685732B2 (en) | 1998-03-31 | 2004-02-03 | Innercool Therapies, Inc. | Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon |
WO2004074454A2 (en) | 2003-02-20 | 2004-09-02 | University Of Connecticut Health Center | Methods and compositions for the treatment of cancer and infectious disease using alpha (2) macroglobulin-antigenic molecule complexes |
US20050005626A1 (en) * | 2003-07-08 | 2005-01-13 | Mcmahon Richard | Cooling device for pain relief |
US6905494B2 (en) | 1998-03-31 | 2005-06-14 | Innercool Therapies, Inc. | Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection |
WO2005092433A1 (en) * | 2004-03-25 | 2005-10-06 | University College Cork - National University Of Ireland, Cork | Apparatus for prophylaxis or treatment of tissue |
US20050251118A1 (en) * | 2004-05-07 | 2005-11-10 | Anderson Robert S | Apparatus and method having a cooling material and reduced pressure to treat biological external tissue |
US20050251117A1 (en) * | 2004-05-07 | 2005-11-10 | Anderson Robert S | Apparatus and method for treating biological external tissue |
US7001378B2 (en) | 1998-03-31 | 2006-02-21 | Innercool Therapies, Inc. | Method and device for performing cooling or cryo-therapies, for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection |
US20060189964A1 (en) * | 2004-05-07 | 2006-08-24 | Anderson Robert S | Apparatus and method to apply substances to tissue |
US20070179482A1 (en) * | 2004-05-07 | 2007-08-02 | Anderson Robert S | Apparatuses and methods to treat biological external tissue |
US7291144B2 (en) | 1998-03-31 | 2007-11-06 | Innercool Therapies, Inc. | Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation |
US7371254B2 (en) | 1998-01-23 | 2008-05-13 | Innercool Therapies, Inc. | Medical procedure |
US20090012434A1 (en) * | 2007-07-03 | 2009-01-08 | Anderson Robert S | Apparatus, method, and system to treat a volume of skin |
US20090069795A1 (en) * | 2007-09-10 | 2009-03-12 | Anderson Robert S | Apparatus and method for selective treatment of tissue |
US20090093864A1 (en) * | 2007-10-08 | 2009-04-09 | Anderson Robert S | Methods and devices for applying energy to tissue |
US7857781B2 (en) | 1998-04-21 | 2010-12-28 | Zoll Circulation, Inc. | Indwelling heat exchange catheter and method of using same |
US8163000B2 (en) | 1998-01-23 | 2012-04-24 | Innercool Therapies, Inc. | Selective organ cooling catheter with guidewire apparatus and temperature-monitoring device |
US20150031126A1 (en) * | 2008-12-16 | 2015-01-29 | Nico Corporation | System and method of taking and collecting tissue cores for treatment |
US10130420B2 (en) | 2015-10-08 | 2018-11-20 | Biosense Webster (Israel) Ltd. | Catheter with membraned spines for pulmonary vein isolation |
WO2021102301A1 (en) | 2019-11-20 | 2021-05-27 | B2M Medical, Inc. | Systems and methods for treatment of visceral fat |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5411494U (sv) * | 1977-06-28 | 1979-01-25 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US796114A (en) * | 1905-06-14 | 1905-08-01 | Herschel E Currey | Electrotherapeutic apparatus. |
US872688A (en) * | 1903-12-30 | 1907-12-03 | Edward S Saighman | Electrical and thermal cupping device. |
US1011606A (en) * | 1910-03-05 | 1911-12-12 | Jacob A Fulton | Appliance for subjecting portions of the human system to heat or cold. |
US1991784A (en) * | 1932-07-28 | 1935-02-19 | Charles A Bohemier | Refrigerant applicator |
US3298371A (en) * | 1965-02-11 | 1967-01-17 | Arnold S J Lee | Freezing probe for the treatment of tissue, especially in neurosurgery |
US3425419A (en) * | 1964-08-08 | 1969-02-04 | Angelo Actis Dato | Method of lowering and raising the temperature of the human body |
-
1970
- 1970-03-13 JP JP45020904A patent/JPS5231674B1/ja active Pending
- 1970-03-17 CH CH401370A patent/CH522397A/de not_active IP Right Cessation
- 1970-03-25 US US23165A patent/US3674031A/en not_active Expired - Lifetime
- 1970-03-26 GB GB04708/70A patent/GB1271881A/en not_active Expired
- 1970-03-27 FR FR7011276A patent/FR2040113A5/fr not_active Expired
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US872688A (en) * | 1903-12-30 | 1907-12-03 | Edward S Saighman | Electrical and thermal cupping device. |
US796114A (en) * | 1905-06-14 | 1905-08-01 | Herschel E Currey | Electrotherapeutic apparatus. |
US1011606A (en) * | 1910-03-05 | 1911-12-12 | Jacob A Fulton | Appliance for subjecting portions of the human system to heat or cold. |
US1991784A (en) * | 1932-07-28 | 1935-02-19 | Charles A Bohemier | Refrigerant applicator |
US3425419A (en) * | 1964-08-08 | 1969-02-04 | Angelo Actis Dato | Method of lowering and raising the temperature of the human body |
US3298371A (en) * | 1965-02-11 | 1967-01-17 | Arnold S J Lee | Freezing probe for the treatment of tissue, especially in neurosurgery |
Cited By (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3794039A (en) * | 1969-10-25 | 1974-02-26 | Linde Ag | Apparatus for cryosurgery |
US3926006A (en) * | 1973-04-09 | 1975-12-16 | Cap Con International Inc | Method and apparatus of freezing a plug in a pipe for pressure testing |
US3934589A (en) * | 1973-05-26 | 1976-01-27 | Dragerwerk Aktiengesellschaft | Surgical instrument for sterilizing women by ligature of tubes |
US3862627A (en) * | 1973-08-16 | 1975-01-28 | Sr Wendel J Hans | Suction electrode |
US4082096A (en) * | 1973-12-10 | 1978-04-04 | Benson Jerrel W | Cryosurgical system |
US4072152A (en) * | 1976-02-23 | 1978-02-07 | Linehan John H | Orthopedic cryosurgical apparatus |
US4135497A (en) * | 1977-03-18 | 1979-01-23 | E-Z-Em Company, Inc. | Apparatus for detecting temperature variations over selected regions of living tissue, and method thereof |
USRE30446E (en) * | 1979-03-16 | 1980-12-16 | E-Z-Em Company, Inc. | Apparatus for detecting temperature variations over selected regions of living tissue, and method thereof |
US4440167A (en) * | 1980-12-26 | 1984-04-03 | Kabushikikaisha Yoshida | Anesthetizer for dental treatment |
US4327733A (en) * | 1981-01-28 | 1982-05-04 | Governing Council Of The University Of Toronto | Cryoenucleation tool |
US5034006A (en) * | 1987-06-22 | 1991-07-23 | Takeda Chemical Industries, Ltd. | Suction equipment for medical operation |
US5271234A (en) * | 1992-12-18 | 1993-12-21 | David L. Carter | Apparatus for and method of removing tile from a floor |
US5433717A (en) * | 1993-03-23 | 1995-07-18 | The Regents Of The University Of California | Magnetic resonance imaging assisted cryosurgery |
US5706810A (en) * | 1993-03-23 | 1998-01-13 | The Regents Of The University Of California | Magnetic resonance imaging assisted cryosurgery |
US7063718B2 (en) | 1998-01-23 | 2006-06-20 | Innercool Therapies, Inc. | Selective organ hypothermia method and apparatus |
US6482226B1 (en) | 1998-01-23 | 2002-11-19 | Innercool Therapies, Inc. | Selective organ hypothermia method and apparatus |
US6491039B1 (en) | 1998-01-23 | 2002-12-10 | Innercool Therapies, Inc. | Medical procedure |
US6558412B2 (en) | 1998-01-23 | 2003-05-06 | Innercool Therapies, Inc. | Selective organ hypothermia method and apparatus |
US8163000B2 (en) | 1998-01-23 | 2012-04-24 | Innercool Therapies, Inc. | Selective organ cooling catheter with guidewire apparatus and temperature-monitoring device |
US7951183B2 (en) | 1998-01-23 | 2011-05-31 | Innercool Therapies, Inc. | Medical procedure |
US6755850B2 (en) | 1998-01-23 | 2004-06-29 | Innercool Therapies, Inc. | Selective organ hypothermia method and apparatus |
US7371254B2 (en) | 1998-01-23 | 2008-05-13 | Innercool Therapies, Inc. | Medical procedure |
US6786218B2 (en) | 1998-01-23 | 2004-09-07 | Innercool Therapies, Inc. | Medical procedure |
US7449018B2 (en) | 1998-03-31 | 2008-11-11 | Innercool Therapies, Inc. | Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon |
US6905494B2 (en) | 1998-03-31 | 2005-06-14 | Innercool Therapies, Inc. | Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection |
US6685732B2 (en) | 1998-03-31 | 2004-02-03 | Innercool Therapies, Inc. | Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon |
US7291144B2 (en) | 1998-03-31 | 2007-11-06 | Innercool Therapies, Inc. | Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation |
US7288089B2 (en) | 1998-03-31 | 2007-10-30 | Innercool Therapies, Inc. | Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection |
US6602276B2 (en) | 1998-03-31 | 2003-08-05 | Innercool Therapies, Inc. | Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation |
US7001378B2 (en) | 1998-03-31 | 2006-02-21 | Innercool Therapies, Inc. | Method and device for performing cooling or cryo-therapies, for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection |
US8157794B2 (en) | 1998-03-31 | 2012-04-17 | Innercool Therapies, Inc. | Method and device for performing cooling-or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation |
US8043351B2 (en) | 1998-03-31 | 2011-10-25 | Innercool Therapies, Inc. | Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection |
US8043283B2 (en) | 1998-03-31 | 2011-10-25 | Innercool Therapies, Inc. | Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation |
US7857781B2 (en) | 1998-04-21 | 2010-12-28 | Zoll Circulation, Inc. | Indwelling heat exchange catheter and method of using same |
US6148619A (en) * | 1999-08-17 | 2000-11-21 | Evans; Daniel J. | Method and apparatus for non-invasively freezing a content of a pipe |
WO2004074454A2 (en) | 2003-02-20 | 2004-09-02 | University Of Connecticut Health Center | Methods and compositions for the treatment of cancer and infectious disease using alpha (2) macroglobulin-antigenic molecule complexes |
US20050005626A1 (en) * | 2003-07-08 | 2005-01-13 | Mcmahon Richard | Cooling device for pain relief |
US8545497B2 (en) | 2004-03-25 | 2013-10-01 | University College Cork—National University of Ireland, Cork | Apparatus for use in the prophylaxis or treatment of tissue |
WO2005092433A1 (en) * | 2004-03-25 | 2005-10-06 | University College Cork - National University Of Ireland, Cork | Apparatus for prophylaxis or treatment of tissue |
US20050251117A1 (en) * | 2004-05-07 | 2005-11-10 | Anderson Robert S | Apparatus and method for treating biological external tissue |
US20070179482A1 (en) * | 2004-05-07 | 2007-08-02 | Anderson Robert S | Apparatuses and methods to treat biological external tissue |
US8571648B2 (en) | 2004-05-07 | 2013-10-29 | Aesthera | Apparatus and method to apply substances to tissue |
US20050251118A1 (en) * | 2004-05-07 | 2005-11-10 | Anderson Robert S | Apparatus and method having a cooling material and reduced pressure to treat biological external tissue |
US7842029B2 (en) | 2004-05-07 | 2010-11-30 | Aesthera | Apparatus and method having a cooling material and reduced pressure to treat biological external tissue |
WO2005112815A1 (en) * | 2004-05-07 | 2005-12-01 | Aesthera | Apparatus having a cooling material and reduced pressure to treat biological external tissue |
US20060189964A1 (en) * | 2004-05-07 | 2006-08-24 | Anderson Robert S | Apparatus and method to apply substances to tissue |
JP2008539907A (ja) * | 2005-05-06 | 2008-11-20 | エステラ | 組織に物質を塗布するための装置及び方法 |
WO2006122136A2 (en) * | 2005-05-06 | 2006-11-16 | Aesthera | Apparatus and method to apply substances to tissue |
WO2006122136A3 (en) * | 2005-05-06 | 2008-02-14 | Aesthera | Apparatus and method to apply substances to tissue |
US20090012434A1 (en) * | 2007-07-03 | 2009-01-08 | Anderson Robert S | Apparatus, method, and system to treat a volume of skin |
US20090069795A1 (en) * | 2007-09-10 | 2009-03-12 | Anderson Robert S | Apparatus and method for selective treatment of tissue |
US20090093864A1 (en) * | 2007-10-08 | 2009-04-09 | Anderson Robert S | Methods and devices for applying energy to tissue |
US20150031126A1 (en) * | 2008-12-16 | 2015-01-29 | Nico Corporation | System and method of taking and collecting tissue cores for treatment |
US10048176B2 (en) * | 2008-12-16 | 2018-08-14 | Nico Corporation | System and method of taking and collecting tissue cores for treatment |
US11609160B2 (en) | 2008-12-16 | 2023-03-21 | Nico Corporation | System and method of taking and collecting tissue cores for treatment |
US10130420B2 (en) | 2015-10-08 | 2018-11-20 | Biosense Webster (Israel) Ltd. | Catheter with membraned spines for pulmonary vein isolation |
WO2021102301A1 (en) | 2019-11-20 | 2021-05-27 | B2M Medical, Inc. | Systems and methods for treatment of visceral fat |
EP4061264A4 (en) * | 2019-11-20 | 2022-12-28 | B2M Medical, Inc. | SYSTEMS AND METHODS FOR TREATMENT OF VISCERAL FAT |
Also Published As
Publication number | Publication date |
---|---|
FR2040113A5 (sv) | 1971-01-15 |
JPS5231674B1 (sv) | 1977-08-16 |
DE1916343B2 (de) | 1972-06-15 |
CH522397A (de) | 1972-06-30 |
DE1916343A1 (de) | 1970-10-01 |
GB1271881A (en) | 1972-04-26 |
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