US3674031A - Method of and device for cryogenic surgery - Google Patents

Method of and device for cryogenic surgery Download PDF

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Publication number
US3674031A
US3674031A US23165A US3674031DA US3674031A US 3674031 A US3674031 A US 3674031A US 23165 A US23165 A US 23165A US 3674031D A US3674031D A US 3674031DA US 3674031 A US3674031 A US 3674031A
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United States
Prior art keywords
tissue
concavity
wall
shell
cell tissue
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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US23165A
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English (en)
Inventor
Hans-Joachim Weiche
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Linde GmbH
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Linde GmbH
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Publication date
Priority claimed from DE19691916343 external-priority patent/DE1916343C/de
Application filed by Linde GmbH filed Critical Linde GmbH
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Publication of US3674031A publication Critical patent/US3674031A/en
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Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/30—Surgical pincettes, i.e. surgical tweezers without pivotal connections
    • A61B2017/306—Surgical pincettes, i.e. surgical tweezers without pivotal connections holding by means of suction

Definitions

  • cryogenic devices for a rapidly expanding branch of surgery referred to as "cryosurgery or low-temperature surgery.
  • a low-temperature fluid e.g., liquid nitrogen
  • a probe or like structure which is applied to the tissue to be treated or removed, thereby abstracting heat rapidly from this tissue and destroying the tissue structure so that the 2 thereof with minimum damage to the vascular system adjoining such tissues.
  • cryogenic probes have been proposed to make use of such cryogenic probes in tonsillectomies which heretofore have required local anesthetic and enucleation or extirpation of the cellular tissue with prolonged convalescence and bed rest. Furthermore, the conventional operation was bloody and could not be carried out effectively with patients in whom loss of blood might lead to other complications.
  • the use of the cryogenic probe eliminated these difficulties by permitting removal of the tonsil follicles without bleeding and while the patient remains ambulatory.
  • the tonsils may be wholly or partly removed upon necrosis resulting from contact with the cryogenic probe.
  • Anotherobject of this invention is to provide an improved apparatus or device for the removal of cellular tissue, especially mammalian tissue, without excessive damage to sur workers in the field with minimum danger of complications and maximum effectiveness for the removal of tonsils and like cellular tissue.
  • a concave shellat the end of the cryogenic instrument which may be placed over the area to be subjected to cryogenic surgery and communicating with a suction source while being provided with means for cooling the wall of this cell externally of the concavity.
  • the present system thus includes a suction device for drawing'the cellular tissue into the concavity concurrently with the cryogenic freezing of this tisue by heat transferthrough the wall of the cavity of a cryogenic fluid in contact with this wall.
  • the cooling system may includemeans for circulating a coolant through the'instrument or merely designed to deliver a coolant to the surface whereupon the coolant may be discharged.
  • the suction action in accordance'with the present invention makes use of a cavity which is preferably dimensioned to the volume of the cellular tissue. to be affected by cryogenic surgery,i.e;, the volumeof the tissue to b'e-removed. It hasbeen found, most surprisingly, that by drawing the removabletissue out of its normal position, e.g., by distorting'the'tissueinto the concavity, it is possible to transfer cold to this limited volume resides in the convergence of the cold upon'the cellular tissue drawn into the concavity and the exclusion of adjacent tissue from-cryogenic attack. When the system is applied to tonsillectomies, therefore, the cryogenic attack and removal is limited to the tonsil follicles without any danger of adversely affecting the vascular system communicating blood to and from the head.
  • the instrument according to the invention is advantageously provided with a hollow body open at one end and constituting a shell, the outer rim of which is bent outis preferably composed of a material having a high'coefi'icient' of heat transfer, advantageously a metal which is-inert and may be of the type commonly employed in surgical instruments: silver, stainless steel or the like. It has been found to be advantageous, moreover, to provide the concavity with a ratio of depth-to-mouth diameter between 1:10 and 1:1 and to provide a wall thickness which is of the order of millimeter and is in a ratio to the depth of the cavity between 1:2 and 1:10.
  • the hollow shell is of double-wall construction, i.e., is formed with a compartment extending along the outer wall of the concavity and constituting a cooling compartrnent and a handle may be provided in the form of a coaxial-tube arrangement one tube of which serves to deliver the coolant while the other carries it away from this chamber.
  • the inner tube which may be of relatively small diameter, supplies cryogenic liquid which expands into the chamber and passes through the outer tube as a vapor or gas.
  • the present invention while finding its most significant application in cryogenic surgery and in the treatment of human cellular tissue is also suitable for use in biology and veterinary medicine in general. In fact, wherever more or less flexible materials are to be cryogenically treated, the instrument of the present invention finds application.
  • FIG. 1 is an axial cross-sectional view schematically illus trating the principles of the present invention
  • FIG. 2 is a sectional view similar to FIG. 1 showing the instrument in operation
  • FIG. 3 is a further sectional view of a preferred embodiment of the invention.
  • FIGS. 1 .and 2 I have shown a device for performing tonsillectomies'but which is suitable for other cryogenic operations and substantially any treatment of relatively soft matter with cold.
  • the device comprises a thin-walled metal cup 1 having a shell configuration and formed with a concavity In which is open against the tissue portion 2 to be treated with cold.
  • the depth d of the concavity can be a fraction of the mouth diameter D or may equal or exceed this diameter as shown in FIG. 3 and as described above.
  • the mouth lb of the shell 1 is formed with an outwardly turned and rounded rim 1c which defines a radius portion 1d at the annulus with which the instrument contacts the tissue 2. The radius 1d prevents tearing of the tissue when the latter is drawn by suction into the concavity la.
  • an orifice 1 which communicates between the concavity la and a tube 3 formed unitarily with the wall 2 and serving to apply suction to the concavity, e.g., via a suction pump or aspirator 3a.
  • FIG. 2 I have shown the instrument of FIG. 1 in opera tion. Suction applied to the bore 3b of tube 3 reduces the pressure within the concavity la, thereby drawing the tissue body 2b surrounded within the annulus 1b into the concavity and into contact with the inner surface thereof.
  • a cryogenic cooling medium e. g., nitrogen, passes the outer surface 1b of the shell 1 as represented at 4, thereby cooling the shell which lies in heat conductive relationship to the bulge 2b of tissue received within the concavity.
  • the cold transfer is represented diagrammatically by the arrows in FIG. 2 and appears to converge to a center close to the center of curvature of the inner wall of the concavity.
  • the shell 8 is substantially hemispherical and is formed as a double wall or socket body, the outer wall of which is represented at 7.
  • the walls are formed unitarily with one another and adjoin at the rounded rim 8a defining an annulus contacting the tissue surface 2.
  • the inner chamber 9 of the hollow-wall body 5 is a cooling compartment to which the coolant supplies via a passage 10a in an inner duct leading from a refrigerating system or liquid nitrogen tank 10b to the interior of the compartment 9.
  • the tube 10 is coaxially surrounded by 'a tube 11, also unitary with'a hollow body 5, and defining a passage 11a of greater cross section than the passage 10a. Consequently a liquid coolant (generally liquid nitrogen) passes through the narrow bore 10a and expands in the chamber 9 with the formed gases emerging via the passage 11:: for recycling or release.
  • the coaxial tubes wand 11 or the tube 6 may constitute a handle or may be mounted in a handle to facilitate manipulation of the device by the surgeon.
  • the tube 6, whose bore 60 opens into an orifice 6b at the apex of the concavity 8b, is connected to a suction pump 6c as described with reference to the embodiment of FIGS. 1 and 2.
  • the device of FIG. 3 operates identically to the device of FIGS. 1 and 2 I claim:
  • a method of cold-treating soft material comprising the 7 steps of juxtaposing with a body of cell tissue, a rigid thermally conductive metal shell concave in the direction of said cell tissue; evacuating'said shell to draw a portion of said cell tissue said method further comprising the step of withdrawing said shell from said body while maintaining suction in said concavity subsequent to the transfer of cold to said portion of said material.
  • An instrument for cryogenic surgery upon mammalian cell tissue comprising:
  • a rigid metal cup mounted on an end of said handle and having a concavity adapted to be applied to said tissue, said cup being formed .with a pair of spaced-apart walls def'ming an interwall compartment and including an inner wall and an outer wall;
  • conduit means connected to said cup and communicating with said concavity
  • a suction pump connected to said conduit means for evacuating said concavity and drawing said tissue against the inner wall.

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Surgical Instruments (AREA)
  • Manufacture And Refinement Of Metals (AREA)
US23165A 1969-03-29 1970-03-25 Method of and device for cryogenic surgery Expired - Lifetime US3674031A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19691916343 DE1916343C (de) 1969-03-29 Vorrichtung für die Chirurgie an menschlichem Zellgewebe, insbesondere Mandelgewebe

Publications (1)

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US3674031A true US3674031A (en) 1972-07-04

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US23165A Expired - Lifetime US3674031A (en) 1969-03-29 1970-03-25 Method of and device for cryogenic surgery

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US (1) US3674031A (enrdf_load_stackoverflow)
JP (1) JPS5231674B1 (enrdf_load_stackoverflow)
CH (1) CH522397A (enrdf_load_stackoverflow)
FR (1) FR2040113A5 (enrdf_load_stackoverflow)
GB (1) GB1271881A (enrdf_load_stackoverflow)

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3794039A (en) * 1969-10-25 1974-02-26 Linde Ag Apparatus for cryosurgery
US3862627A (en) * 1973-08-16 1975-01-28 Sr Wendel J Hans Suction electrode
US3926006A (en) * 1973-04-09 1975-12-16 Cap Con International Inc Method and apparatus of freezing a plug in a pipe for pressure testing
US3934589A (en) * 1973-05-26 1976-01-27 Dragerwerk Aktiengesellschaft Surgical instrument for sterilizing women by ligature of tubes
US4072152A (en) * 1976-02-23 1978-02-07 Linehan John H Orthopedic cryosurgical apparatus
US4082096A (en) * 1973-12-10 1978-04-04 Benson Jerrel W Cryosurgical system
US4135497A (en) * 1977-03-18 1979-01-23 E-Z-Em Company, Inc. Apparatus for detecting temperature variations over selected regions of living tissue, and method thereof
USRE30446E (en) * 1979-03-16 1980-12-16 E-Z-Em Company, Inc. Apparatus for detecting temperature variations over selected regions of living tissue, and method thereof
US4327733A (en) * 1981-01-28 1982-05-04 Governing Council Of The University Of Toronto Cryoenucleation tool
US4440167A (en) * 1980-12-26 1984-04-03 Kabushikikaisha Yoshida Anesthetizer for dental treatment
US5034006A (en) * 1987-06-22 1991-07-23 Takeda Chemical Industries, Ltd. Suction equipment for medical operation
USD320074S (en) 1987-04-16 1991-09-17 Unisearch Limited Opthalmic applicator for irradiation of intra-ocular tumors or the like
US5271234A (en) * 1992-12-18 1993-12-21 David L. Carter Apparatus for and method of removing tile from a floor
US5433717A (en) * 1993-03-23 1995-07-18 The Regents Of The University Of California Magnetic resonance imaging assisted cryosurgery
US6148619A (en) * 1999-08-17 2000-11-21 Evans; Daniel J. Method and apparatus for non-invasively freezing a content of a pipe
US6482226B1 (en) 1998-01-23 2002-11-19 Innercool Therapies, Inc. Selective organ hypothermia method and apparatus
US6491039B1 (en) 1998-01-23 2002-12-10 Innercool Therapies, Inc. Medical procedure
US6558412B2 (en) 1998-01-23 2003-05-06 Innercool Therapies, Inc. Selective organ hypothermia method and apparatus
US6602276B2 (en) 1998-03-31 2003-08-05 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US6685732B2 (en) 1998-03-31 2004-02-03 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon
WO2004074454A2 (en) 2003-02-20 2004-09-02 University Of Connecticut Health Center Methods and compositions for the treatment of cancer and infectious disease using alpha (2) macroglobulin-antigenic molecule complexes
US20050005626A1 (en) * 2003-07-08 2005-01-13 Mcmahon Richard Cooling device for pain relief
US6905494B2 (en) 1998-03-31 2005-06-14 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
WO2005092433A1 (en) * 2004-03-25 2005-10-06 University College Cork - National University Of Ireland, Cork Apparatus for prophylaxis or treatment of tissue
US20050251118A1 (en) * 2004-05-07 2005-11-10 Anderson Robert S Apparatus and method having a cooling material and reduced pressure to treat biological external tissue
US20050251117A1 (en) * 2004-05-07 2005-11-10 Anderson Robert S Apparatus and method for treating biological external tissue
US7001378B2 (en) 1998-03-31 2006-02-21 Innercool Therapies, Inc. Method and device for performing cooling or cryo-therapies, for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US20060189964A1 (en) * 2004-05-07 2006-08-24 Anderson Robert S Apparatus and method to apply substances to tissue
US20070179482A1 (en) * 2004-05-07 2007-08-02 Anderson Robert S Apparatuses and methods to treat biological external tissue
US7291144B2 (en) 1998-03-31 2007-11-06 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US7371254B2 (en) 1998-01-23 2008-05-13 Innercool Therapies, Inc. Medical procedure
US20090012434A1 (en) * 2007-07-03 2009-01-08 Anderson Robert S Apparatus, method, and system to treat a volume of skin
US20090069795A1 (en) * 2007-09-10 2009-03-12 Anderson Robert S Apparatus and method for selective treatment of tissue
US20090093864A1 (en) * 2007-10-08 2009-04-09 Anderson Robert S Methods and devices for applying energy to tissue
US7857781B2 (en) 1998-04-21 2010-12-28 Zoll Circulation, Inc. Indwelling heat exchange catheter and method of using same
US8163000B2 (en) 1998-01-23 2012-04-24 Innercool Therapies, Inc. Selective organ cooling catheter with guidewire apparatus and temperature-monitoring device
US20150031126A1 (en) * 2008-12-16 2015-01-29 Nico Corporation System and method of taking and collecting tissue cores for treatment
US10130420B2 (en) 2015-10-08 2018-11-20 Biosense Webster (Israel) Ltd. Catheter with membraned spines for pulmonary vein isolation
WO2021102301A1 (en) 2019-11-20 2021-05-27 B2M Medical, Inc. Systems and methods for treatment of visceral fat

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5411494U (enrdf_load_stackoverflow) * 1977-06-28 1979-01-25

Citations (6)

* Cited by examiner, † Cited by third party
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US796114A (en) * 1905-06-14 1905-08-01 Herschel E Currey Electrotherapeutic apparatus.
US872688A (en) * 1903-12-30 1907-12-03 Edward S Saighman Electrical and thermal cupping device.
US1011606A (en) * 1910-03-05 1911-12-12 Jacob A Fulton Appliance for subjecting portions of the human system to heat or cold.
US1991784A (en) * 1932-07-28 1935-02-19 Charles A Bohemier Refrigerant applicator
US3298371A (en) * 1965-02-11 1967-01-17 Arnold S J Lee Freezing probe for the treatment of tissue, especially in neurosurgery
US3425419A (en) * 1964-08-08 1969-02-04 Angelo Actis Dato Method of lowering and raising the temperature of the human body

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US872688A (en) * 1903-12-30 1907-12-03 Edward S Saighman Electrical and thermal cupping device.
US796114A (en) * 1905-06-14 1905-08-01 Herschel E Currey Electrotherapeutic apparatus.
US1011606A (en) * 1910-03-05 1911-12-12 Jacob A Fulton Appliance for subjecting portions of the human system to heat or cold.
US1991784A (en) * 1932-07-28 1935-02-19 Charles A Bohemier Refrigerant applicator
US3425419A (en) * 1964-08-08 1969-02-04 Angelo Actis Dato Method of lowering and raising the temperature of the human body
US3298371A (en) * 1965-02-11 1967-01-17 Arnold S J Lee Freezing probe for the treatment of tissue, especially in neurosurgery

Cited By (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3794039A (en) * 1969-10-25 1974-02-26 Linde Ag Apparatus for cryosurgery
US3926006A (en) * 1973-04-09 1975-12-16 Cap Con International Inc Method and apparatus of freezing a plug in a pipe for pressure testing
US3934589A (en) * 1973-05-26 1976-01-27 Dragerwerk Aktiengesellschaft Surgical instrument for sterilizing women by ligature of tubes
US3862627A (en) * 1973-08-16 1975-01-28 Sr Wendel J Hans Suction electrode
US4082096A (en) * 1973-12-10 1978-04-04 Benson Jerrel W Cryosurgical system
US4072152A (en) * 1976-02-23 1978-02-07 Linehan John H Orthopedic cryosurgical apparatus
US4135497A (en) * 1977-03-18 1979-01-23 E-Z-Em Company, Inc. Apparatus for detecting temperature variations over selected regions of living tissue, and method thereof
USRE30446E (en) * 1979-03-16 1980-12-16 E-Z-Em Company, Inc. Apparatus for detecting temperature variations over selected regions of living tissue, and method thereof
US4440167A (en) * 1980-12-26 1984-04-03 Kabushikikaisha Yoshida Anesthetizer for dental treatment
US4327733A (en) * 1981-01-28 1982-05-04 Governing Council Of The University Of Toronto Cryoenucleation tool
USD320074S (en) 1987-04-16 1991-09-17 Unisearch Limited Opthalmic applicator for irradiation of intra-ocular tumors or the like
US5034006A (en) * 1987-06-22 1991-07-23 Takeda Chemical Industries, Ltd. Suction equipment for medical operation
US5271234A (en) * 1992-12-18 1993-12-21 David L. Carter Apparatus for and method of removing tile from a floor
US5433717A (en) * 1993-03-23 1995-07-18 The Regents Of The University Of California Magnetic resonance imaging assisted cryosurgery
US5706810A (en) * 1993-03-23 1998-01-13 The Regents Of The University Of California Magnetic resonance imaging assisted cryosurgery
US7951183B2 (en) 1998-01-23 2011-05-31 Innercool Therapies, Inc. Medical procedure
US6482226B1 (en) 1998-01-23 2002-11-19 Innercool Therapies, Inc. Selective organ hypothermia method and apparatus
US6491039B1 (en) 1998-01-23 2002-12-10 Innercool Therapies, Inc. Medical procedure
US6558412B2 (en) 1998-01-23 2003-05-06 Innercool Therapies, Inc. Selective organ hypothermia method and apparatus
US7371254B2 (en) 1998-01-23 2008-05-13 Innercool Therapies, Inc. Medical procedure
US7063718B2 (en) 1998-01-23 2006-06-20 Innercool Therapies, Inc. Selective organ hypothermia method and apparatus
US6755850B2 (en) 1998-01-23 2004-06-29 Innercool Therapies, Inc. Selective organ hypothermia method and apparatus
US8163000B2 (en) 1998-01-23 2012-04-24 Innercool Therapies, Inc. Selective organ cooling catheter with guidewire apparatus and temperature-monitoring device
US6786218B2 (en) 1998-01-23 2004-09-07 Innercool Therapies, Inc. Medical procedure
US6685732B2 (en) 1998-03-31 2004-02-03 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon
US7288089B2 (en) 1998-03-31 2007-10-30 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US7449018B2 (en) 1998-03-31 2008-11-11 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon
US6602276B2 (en) 1998-03-31 2003-08-05 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US8043283B2 (en) 1998-03-31 2011-10-25 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US7291144B2 (en) 1998-03-31 2007-11-06 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US7001378B2 (en) 1998-03-31 2006-02-21 Innercool Therapies, Inc. Method and device for performing cooling or cryo-therapies, for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US6905494B2 (en) 1998-03-31 2005-06-14 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US8157794B2 (en) 1998-03-31 2012-04-17 Innercool Therapies, Inc. Method and device for performing cooling-or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US8043351B2 (en) 1998-03-31 2011-10-25 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US7857781B2 (en) 1998-04-21 2010-12-28 Zoll Circulation, Inc. Indwelling heat exchange catheter and method of using same
US6148619A (en) * 1999-08-17 2000-11-21 Evans; Daniel J. Method and apparatus for non-invasively freezing a content of a pipe
WO2004074454A2 (en) 2003-02-20 2004-09-02 University Of Connecticut Health Center Methods and compositions for the treatment of cancer and infectious disease using alpha (2) macroglobulin-antigenic molecule complexes
US20050005626A1 (en) * 2003-07-08 2005-01-13 Mcmahon Richard Cooling device for pain relief
US8545497B2 (en) 2004-03-25 2013-10-01 University College Cork—National University of Ireland, Cork Apparatus for use in the prophylaxis or treatment of tissue
WO2005092433A1 (en) * 2004-03-25 2005-10-06 University College Cork - National University Of Ireland, Cork Apparatus for prophylaxis or treatment of tissue
US20050251117A1 (en) * 2004-05-07 2005-11-10 Anderson Robert S Apparatus and method for treating biological external tissue
US20070179482A1 (en) * 2004-05-07 2007-08-02 Anderson Robert S Apparatuses and methods to treat biological external tissue
US8571648B2 (en) 2004-05-07 2013-10-29 Aesthera Apparatus and method to apply substances to tissue
US7842029B2 (en) 2004-05-07 2010-11-30 Aesthera Apparatus and method having a cooling material and reduced pressure to treat biological external tissue
US20050251118A1 (en) * 2004-05-07 2005-11-10 Anderson Robert S Apparatus and method having a cooling material and reduced pressure to treat biological external tissue
WO2005112815A1 (en) * 2004-05-07 2005-12-01 Aesthera Apparatus having a cooling material and reduced pressure to treat biological external tissue
US20060189964A1 (en) * 2004-05-07 2006-08-24 Anderson Robert S Apparatus and method to apply substances to tissue
JP2008539907A (ja) * 2005-05-06 2008-11-20 エステラ 組織に物質を塗布するための装置及び方法
WO2006122136A3 (en) * 2005-05-06 2008-02-14 Aesthera Apparatus and method to apply substances to tissue
US20090012434A1 (en) * 2007-07-03 2009-01-08 Anderson Robert S Apparatus, method, and system to treat a volume of skin
US20090069795A1 (en) * 2007-09-10 2009-03-12 Anderson Robert S Apparatus and method for selective treatment of tissue
US20090093864A1 (en) * 2007-10-08 2009-04-09 Anderson Robert S Methods and devices for applying energy to tissue
US20150031126A1 (en) * 2008-12-16 2015-01-29 Nico Corporation System and method of taking and collecting tissue cores for treatment
US10048176B2 (en) * 2008-12-16 2018-08-14 Nico Corporation System and method of taking and collecting tissue cores for treatment
US11609160B2 (en) 2008-12-16 2023-03-21 Nico Corporation System and method of taking and collecting tissue cores for treatment
US10130420B2 (en) 2015-10-08 2018-11-20 Biosense Webster (Israel) Ltd. Catheter with membraned spines for pulmonary vein isolation
WO2021102301A1 (en) 2019-11-20 2021-05-27 B2M Medical, Inc. Systems and methods for treatment of visceral fat
EP4061264A4 (en) * 2019-11-20 2022-12-28 B2M Medical, Inc. VISCERAL FAT PROCESSING SYSTEMS AND METHODS

Also Published As

Publication number Publication date
DE1916343B2 (de) 1972-06-15
JPS5231674B1 (enrdf_load_stackoverflow) 1977-08-16
GB1271881A (en) 1972-04-26
FR2040113A5 (enrdf_load_stackoverflow) 1971-01-15
DE1916343A1 (de) 1970-10-01
CH522397A (de) 1972-06-30

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