US3654085A - Storage device for organ transplants - Google Patents
Storage device for organ transplants Download PDFInfo
- Publication number
- US3654085A US3654085A US877217A US3654085DA US3654085A US 3654085 A US3654085 A US 3654085A US 877217 A US877217 A US 877217A US 3654085D A US3654085D A US 3654085DA US 3654085 A US3654085 A US 3654085A
- Authority
- US
- United States
- Prior art keywords
- chamber
- blood
- pump
- storage device
- motor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
Definitions
- a pressure chamber for storing organic transplants and supplying them With oxygenated blood is provided with an oxygenator and a blood pump in the chamber.
- the pump is driven from a motor outside the chamber so as to avoid pressure influence on the blood, a pressuretight transmission connecting the motor with the pump through the chamber wall.
- the invention relates to a device for storage and blood perfusion of an organic transplant.
- This type of storage requires a continuous supply of oxygenated blood to the transplant in order to keep it in fresh condition.
- An oxygenator is provided in the chamber and a blood pump is also necessary to collect blood from the oxygenator and supply it to the transplant, which may be a heart or a liver or some other organ.
- the characteristic feature of the invention consists in that the blood pump is located in the chamber, whereas the motor is placed outside it, a transmission being provided for connecting the motor with the pump through the wall of the chamber in an air-tight manner.
- the storage device comprises a chamber having a cylindrical wall V with a window F provided therein for observation of the interior of the chamber.
- a container B Inserted in the chamber is a container B which is supported by a plate S.
- the plate S rests on guides SK, on which container B can be pushed into or pulled out of the chamber.
- the container has a lid, in which a window F is provided in a position corresponding to that of window F.
- the organic transplant is indicated by L and the artery A thereof is connected via a lead-through at G to a tube SL, which connects the same with the outlet of a blood pump BP.
- the blood issuing from transplant L flows into an oxygenator OX, from which a conduit L' leads to the inlet of blood pump BP.
- the axle AX of blood pump BP is brought out through the chamber wall via a bushing H to connect with a motor M. Also, placed outside the chamber is a pump P for supplying oxygen or air to the chamber under increased pressure via conduits R and lead-throughs G and. G".
- the arrangement of blood pump BP within the chamber removes the drawbacks referred to above, which are present if the blood, is to be brought out of the chamber and back after passage through the pump. There is less energy required to be supplied by the pump and the danger of haemolysis is substantially reduced. This advantage is particularly noticeable in connection with a blood pump of a type known per se comprising elastic tubing which is compressed by rotating rollers moving over the tubing for feeding the blood.
- the lead-through H referred to above may be of any known type which is capable of withstanding a pressure of about 5 to 10 at.
- the pump P can be replaced by some other type of gas supply, such as a container for gas under increased pressure.
- a device for the storage and blood perfusion of organic transplants comprising:
- a pump device in said chamber for maintaining a stream of blood
- first conduit means for conveying said stream of blood from said pump to said organ
- an oxygenator in said chamber positioned to receive blood from said organ
- a device as claimed in claim 1 which includes a support for holding a transplant slidable in said chamber and supporting said oxygenator.
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- External Artificial Organs (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
A PRESSURE CHAMBER FOR STORING ORGANIC TRANSPLANT AND SUPPLYING THEM WITHIN OXYGENATED BLOOD IS PROVIDED WITH AN OXYGENATOR AND A BLOOD PUMP IN THE CHAMBER. THE PUMP IS DRIVEN FROM A MOTOR OUTSIDE THE CHAMBER SO AS TO AVOID PRESSURE INFLUENCE ON THE BLOOD, A PRESSURETIGHT TRANSMISSION CONNECTING THE MOTOR WITH THE PUMP THROUGH THE CHAMBER WALL.
Description
April 4, 1972 A. v. L. NORR ErAL STORAGE DEVICE FOR ORGAN TRANSPLANTS Filed Nov. 17, 1969 INVENTORS ARTUR VALTER LEOPOLD NORR FRITZ BERTIL WILLY HOLM m 32592 ATTORNEYS United States Patent 3,654,085 STORAGE DEVICE FOR ORGAN TRANSPLANTS Artur Valter Leopold Norr and Fritz Bertil Willy Holm, Lidingo, Sweden, assignors to AGA Aktiebolag, Lidingo, Sweden Filed Nov. 17, 1969, Ser. No. 877,217 Claims priority, application Sweden, Nov. 26, 1968, 16,077/ 68 Int. Cl. A61b 19/00 U.S. Cl. 195-127 3 Claims ABSTRACT OF THE DISCLOSURE A pressure chamber for storing organic transplants and supplying them With oxygenated blood is provided with an oxygenator and a blood pump in the chamber. The pump is driven from a motor outside the chamber so as to avoid pressure influence on the blood, a pressuretight transmission connecting the motor with the pump through the chamber wall.
BACKGROUND OF THE INVENTION The invention relates to a device for storage and blood perfusion of an organic transplant.
This type of storage requires a continuous supply of oxygenated blood to the transplant in order to keep it in fresh condition. An oxygenator is provided in the chamber and a blood pump is also necessary to collect blood from the oxygenator and supply it to the transplant, which may be a heart or a liver or some other organ.
If, in a chamber of the type referred to, the blood pump is placed outside the chamber, lead-through conduits for the perfusion blood are required from the interior of the chamber to the pump and from the latter back into the chamber. This requires the blood to overcome the pressure differential between the outside and the interior of the chamber and a corresponding amount of energy must be supplied by the pump. Also, there is an increased danger of haemolysis of the blood.
SUMMARY OF THE INVENTION It is an object of the invention to provide a storage device which obviates the disadvantage referred to. The characteristic feature of the invention consists in that the blood pump is located in the chamber, whereas the motor is placed outside it, a transmission being provided for connecting the motor with the pump through the wall of the chamber in an air-tight manner.
THE DRAWING The attached drawing shows an embodiment of the invention.
DESCRIPTION OF EMBODIMENT The storage device comprises a chamber having a cylindrical wall V with a window F provided therein for observation of the interior of the chamber. Inserted in the chamber is a container B which is supported by a plate S. The plate S rests on guides SK, on which container B can be pushed into or pulled out of the chamber. The container has a lid, in which a window F is provided in a position corresponding to that of window F. The organic transplant is indicated by L and the artery A thereof is connected via a lead-through at G to a tube SL, which connects the same with the outlet of a blood pump BP. The blood issuing from transplant L flows into an oxygenator OX, from which a conduit L' leads to the inlet of blood pump BP. The axle AX of blood pump BP is brought out through the chamber wall via a bushing H to connect with a motor M. Also, placed outside the chamber is a pump P for supplying oxygen or air to the chamber under increased pressure via conduits R and lead-throughs G and. G".
Owing to the fact that the pressure gas is supplied via lead-through G" to container B there is a direct supply of fresh air or oxygen to the transplant.
The arrangement of blood pump BP within the chamber removes the drawbacks referred to above, which are present if the blood, is to be brought out of the chamber and back after passage through the pump. There is less energy required to be supplied by the pump and the danger of haemolysis is substantially reduced. This advantage is particularly noticeable in connection with a blood pump of a type known per se comprising elastic tubing which is compressed by rotating rollers moving over the tubing for feeding the blood.
The lead-through H referred to above may be of any known type which is capable of withstanding a pressure of about 5 to 10 at.
The pump P can be replaced by some other type of gas supply, such as a container for gas under increased pressure.
We claim:
1. A device for the storage and blood perfusion of organic transplants comprising:
a chamber capable of holding gas under increased pressure,
means for supporting an organ in said chamber,
a pump device in said chamber for maintaining a stream of blood,
first conduit means for conveying said stream of blood from said pump to said organ,
an oxygenator in said chamber positioned to receive blood from said organ,
second conduit means for conveying blood from said oxygenator to said pump,
a motor outside of said chamber for driving said pump, and
a transmission member connecting said motor with said pump device through the wall of said chamber in an airtight manner.
2. A device as claimed in claim 1, in which said pump device comprises a flexible tube and rollers movable along said tube and compressing the same.
3. A device as claimed in claim 1, which includes a support for holding a transplant slidable in said chamber and supporting said oxygenator.
References Cited UNITED STATES PATENTS 1(1/ 1968 Swenson et al. 62--306 12/1970 Swenson et al. 62-231 OTHER REFERENCES A. LOUIS MONACELL, Primary Examiner R. B. ANDEWELT, Assistant Examiner U.S. Cl. X.R.
l28--Heart-Lung Digest
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE16077/68A SE323475B (en) | 1968-11-26 | 1968-11-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
US3654085A true US3654085A (en) | 1972-04-04 |
Family
ID=20301697
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US877217A Expired - Lifetime US3654085A (en) | 1968-11-26 | 1969-11-17 | Storage device for organ transplants |
Country Status (7)
Country | Link |
---|---|
US (1) | US3654085A (en) |
JP (1) | JPS4840996B1 (en) |
CH (1) | CH500720A (en) |
DE (1) | DE1958314A1 (en) |
FR (1) | FR2024286A1 (en) |
GB (1) | GB1288926A (en) |
SE (1) | SE323475B (en) |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3777507A (en) * | 1971-11-24 | 1973-12-11 | Waters Instr Inc | Renal preservation system |
US4837390A (en) * | 1983-05-11 | 1989-06-06 | Keyes Offshore, Inc. | Hyperbaric organ preservation apparatus and method for preserving living organs |
US6673594B1 (en) | 1998-09-29 | 2004-01-06 | Organ Recovery Systems | Apparatus and method for maintaining and/or restoring viability of organs |
US20040111104A1 (en) * | 2002-08-23 | 2004-06-10 | Organ Recovery Systems | Cannulas, cannula mount assemblies, and clamping methods using such cannulas and cannula mount assemblies |
US20040171138A1 (en) * | 2002-08-14 | 2004-09-02 | Transmedics, Inc. | Heart preservation chamber |
US20040224298A1 (en) * | 1998-09-29 | 2004-11-11 | John Brassil | Apparatus and method for determining effects of a substance of an organ |
US20040224299A1 (en) * | 2003-04-04 | 2004-11-11 | Organ Recovery Systems | Method and apparatus for transferring heat to or from an organ or tissue container |
US20040221719A1 (en) * | 2003-04-04 | 2004-11-11 | Organ Recovery Systems, Inc. | Device for separating gas from a liquid path |
US20060063142A1 (en) * | 1998-09-29 | 2006-03-23 | Organ Recovery Systems, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US20060148062A1 (en) * | 2004-10-07 | 2006-07-06 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
US20060154357A1 (en) * | 2004-10-07 | 2006-07-13 | Transmedics, Inc. | Systems and methods for ex-vivo organ care |
US20080234768A1 (en) * | 2007-03-20 | 2008-09-25 | Transmedics, Inc | Systems for monitoring and applying electrical currents in an organ perfusion system |
US20090197325A1 (en) * | 2008-01-31 | 2009-08-06 | Transmedics, Inc | SYSTEMS AND METHODS FOR Ex vivo LUNG CARE |
US20110136096A1 (en) * | 2006-04-19 | 2011-06-09 | Transmedics, Inc. | Systems and Methods for Ex Vivo Organ Care |
US8828034B2 (en) | 2011-04-29 | 2014-09-09 | Lifeline Scientific, Inc. | Cannula |
US9022978B2 (en) | 2011-04-29 | 2015-05-05 | Lifeline Scientific, Inc. | Universal sealring cannula |
US9078428B2 (en) | 2005-06-28 | 2015-07-14 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
US9320269B2 (en) | 2009-09-25 | 2016-04-26 | John Brassil | Organ preservation system |
US9642625B2 (en) | 2011-04-29 | 2017-05-09 | Lifeline Scientific, Inc. | Cannula for a donor organ with or without an aortic cuff or patch |
US9756851B2 (en) | 1997-09-23 | 2017-09-12 | The Department Of Veteran Affairs | Compositions, methods and devices for maintaining an organ |
US9894894B2 (en) | 2004-10-07 | 2018-02-20 | Transmedics, Inc. | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
US10076112B2 (en) | 2014-06-02 | 2018-09-18 | Transmedic, Inc. | Ex vivo organ care system |
US10194655B2 (en) | 2015-09-09 | 2019-02-05 | Transmedics, Inc. | Aortic cannula for ex vivo organ care system |
US11856944B2 (en) | 2011-04-14 | 2024-01-02 | Transmedics, Inc. | Organ care solution for ex-vivo machine perfusion of donor lungs |
US11963526B2 (en) | 2014-12-12 | 2024-04-23 | Transmedics, Inc. | Apparatus and method for organ perfusion |
US12010987B2 (en) | 2004-10-07 | 2024-06-18 | Transmedics, Inc. | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
-
1968
- 1968-11-26 SE SE16077/68A patent/SE323475B/xx unknown
-
1969
- 1969-11-17 US US877217A patent/US3654085A/en not_active Expired - Lifetime
- 1969-11-17 GB GB1288926D patent/GB1288926A/en not_active Expired
- 1969-11-20 DE DE19691958314 patent/DE1958314A1/en active Pending
- 1969-11-21 CH CH1737069A patent/CH500720A/en not_active IP Right Cessation
- 1969-11-25 JP JP44094610A patent/JPS4840996B1/ja active Pending
- 1969-11-26 FR FR6940724A patent/FR2024286A1/fr not_active Withdrawn
Cited By (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3777507A (en) * | 1971-11-24 | 1973-12-11 | Waters Instr Inc | Renal preservation system |
US4837390A (en) * | 1983-05-11 | 1989-06-06 | Keyes Offshore, Inc. | Hyperbaric organ preservation apparatus and method for preserving living organs |
US9756850B2 (en) | 1997-09-23 | 2017-09-12 | The Department Of Veteran Affairs | Compositions, methods and devices for maintaining an organ |
US9756849B2 (en) | 1997-09-23 | 2017-09-12 | The Department Of Veteran Affairs | Compositions, methods and devices for maintaining an organ |
US9756851B2 (en) | 1997-09-23 | 2017-09-12 | The Department Of Veteran Affairs | Compositions, methods and devices for maintaining an organ |
US8445260B2 (en) | 1998-09-29 | 2013-05-21 | Lifeline Scientific, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US20100221696A1 (en) * | 1998-09-29 | 2010-09-02 | Organ Recovery Systems, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
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US20060063142A1 (en) * | 1998-09-29 | 2006-03-23 | Organ Recovery Systems, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US8318415B2 (en) | 1998-09-29 | 2012-11-27 | Lifeline Scientific, Inc. | Method of determining transport and/or storage parameters for maintaining viability of an organ |
US6673594B1 (en) | 1998-09-29 | 2004-01-06 | Organ Recovery Systems | Apparatus and method for maintaining and/or restoring viability of organs |
US8962303B2 (en) | 1998-09-29 | 2015-02-24 | Lifeline Scientific, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
US20040224298A1 (en) * | 1998-09-29 | 2004-11-11 | John Brassil | Apparatus and method for determining effects of a substance of an organ |
US8431385B2 (en) | 1998-09-29 | 2013-04-30 | Lifeline Scientific, Inc. | Apparatus and method for maintaining and/or restoring viability of organs |
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US7749693B2 (en) | 1998-09-29 | 2010-07-06 | Lifeline Scientific, Inc. | Method of determining that an organ is not suitable for transplantation and using it for testing substances |
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Also Published As
Publication number | Publication date |
---|---|
CH500720A (en) | 1970-12-31 |
DE1958314A1 (en) | 1970-06-11 |
SE323475B (en) | 1970-05-04 |
JPS4840996B1 (en) | 1973-12-04 |
FR2024286A1 (en) | 1970-08-28 |
GB1288926A (en) | 1972-09-13 |
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