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Capsule for the study and treatment of the digestive tract

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US3485235A
US3485235A US3485235DA US3485235A US 3485235 A US3485235 A US 3485235A US 3485235D A US3485235D A US 3485235DA US 3485235 A US3485235 A US 3485235A
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capsule
bellows
end
tract
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Ronald Felson
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Ronald Felson
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/07Endoradiosondes
    • A61B5/073Intestinal transmitters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045Devices for taking samples of body liquids
    • A61B2010/0061Alimentary tract secretions, e.g. biliary, gastric, intestinal, pancreatic secretions

Description

R. FELSON 3,485,235

CAPSULE FOR THE STUDY AND TREATMENT OF THE DIGESTIVE TRACT Dec. 23, 1969 Filed Dec.

INVENTOR, Ronald Felson ATTORNEY United States Patent US. Cl. 128-2 7 Claims ABSTRACT OF THE DISCLOSURE The longitudinal expansion and contraction of a swallowable telescopic plastic casing is accomplished by heating an ether-filled bellows contained in said casing. The casing parts have openings acting as a valve so the casing is closed when in contracted condition, and open when expanded. The capsule so constituted in contracted condition, is ingested empty or filled with a medicament. The passage of the capsule through the digestive tract is observed with an X-ray apparatus, and when it reaches a certain level, a heat is produced in the patients body by electrical means creating a high frequency magnetic field, which is controlled to operate the bellows to open and close the casing. If the capsule used was empty, it will receive a sample of the fluid of the digestive tract at the zone wherein the capsule was operated. If the capsule used was originally laden with a medicament, the latter will be discharged into said tract, at the selected zone. Later, the capsule is recovered from the feces with the aid of a magnet. The bellows structure includes as its extensible, contractible member, a circumferentially corrugated steel foil tube.

The present invention relates to a capsule to be used for the clinical, physiological and physiopathological examination, study and treatment of the digestive tract and more particularly to a type which is easily swallowed by the patient and then recovered in the feces. Its movement in the body can be observed by X-rays and it can be operated to extract a sample at any level in its travel, of the fluids in the zone of interest or it may carry some chemical or medicament to be discharged into such zone. Essentially, the construction of the capsule affords its opening and closing by controlled radiant heat induced in the body.

Various complicated and costly capsule constructions have heretofore been suggested. Laden with room filling mechanism, leaving hardly any available capacity for sample gathering or medicament carrying, and being slow in action, besides being expensive, hinders their adoption.

It is therefore the principal object of this invention to provide a novel and improved construction for a capsule of the character described, which is simple in structure, easy and reasonable in cost to manufacture, quick to assume open and closed condition and avoiding the objectionable features mentioned, makes for eflicient accomplishment of the purposes for which it is designed.

Other objects and advantages will become apparent as this disclosure proceeds.

For one practice of this invention, part of the interior of a swallowable casing made up of two telescopicallyassociated shells, is taken up by a normally contracted, ether-filled bellows-form chamber whose resilient, longitudinally extensible and contractible member is a circumferentially corrugated steel foil tube. One end of the bellows is fixed at the bottom of one of the shells, and its other end serves as a slidably fitted piston in such one shell, which is provided with an end wall so it is a cylinder structure for said piston. The piston rod extends slidably through such cylinder end, and its distal end extends and is secured to the bottom of the other shell 3,485,235 Patented Dec. 23, 1969 "ice which serves as a cap on the first one. Each shell at mouth end has openings. When the bellows is in contracted condition, which is the normal, said openings are non-communicative, and the cylinders interior is confined. But upon extension of the bellows, said openings come into registry. So these openings form a sort-of valve construction. Passage of the capsule, empty or containing a medicament, through the digestive tract, is observed by means of X-ray apparatus. The expansion and subsequent contraction of the bellows to open and close the casing, is accomplished by controlled electrically induced heat caused to occur in the patients body when the capsule has reached a predetermined zone in the digestive tract, whereupon the empty capsule will receive a sample, and the initially laden capsule will have its contents discharged. Later, the capsule is recovered in the feces with the aid of a magnet.

In the accompanying drawing forming part of this specification similar characters of reference indicate corresponding parts in all the views.

FIG. 1 is a magnified, central elevational section showing a capsule embodying the teachings of this invention, in closed condition, holding a supply of a medicament.

FIG. 2 is a view like FIG. 1, shown only partly in section, but empty.

FIG. 3 is a view like FIG. 2, showing the capsule in open condition.

FIG. 4 is a section taken at line 4-4 in FIG. 3.

In the drawing, the capsule indicated generally by the numeral 15, is made of the two telescopically associated shells 16 and 17, to form an expandible and contractible envelope of swallowable size. The shell 16 serves as a cap on the shell 17, while the latter is provided with an end wall 18 near its mouth, so it is a cylinder for the slidably fitted piston 19, whose rod 20, extends slidingly through the cylinder end 18, to the floor of the cap shell 16, where it is secured at 21. To the floor of the shell 17, is secured the lower end of a bellows-form chamber indicated generally by the numeral 22, comprised of a cylindrical Wall 23, closed at both ends, as shown at 24, and the piston 19 may serve as its top end; said cylindrical wall being a resilient, longitudinally expandable and contractible circumferentially corrugated tube. The bellows chamber is filled with a gas as ether for instance, which quickly expands, when heated. The corrugated tube 23 is preferably made of steel foil plated exteriorally with gold. The piston rod may be of fiberglass. The shells 16 and 17 may be of Teflon or other suitable material which is inert to the contents of the digestive tract and to chemicals and medicaments which in some instances are intended to be carried by the capsule in the space above the bellows chamber, and discharged therefrom into said tract; said shells near month end, having openings, which register respectively when the bellows chamber expands as shown in FIG. 3, but are noncommunicative when said bellows chamber is in its contracted condition, as shown in the FIGS. 1 and 2. Said openings in the cap 16, are indicated by the numeral 25, and in the other shell, by the numeral 26. Seals as 27, 27', 27" are provided to maintain the openings non-communicative with the interior of the shell 17, while the bellows 22 is in contracted condition. Said bellows in such condition which is the normal, occupy about one-third of the shell 17 in the embodiment illustrated, leaving the space which is shown vacant in FIG. 2, but in FIG. 1, it is shown containing a medicament 29. In expanded state, the bellows 22 reaches to about the openings 26. The numerals 21 and 28, denote suitable cement as Epoxy for example, to effect assembly.

The capsule 15, is prepared in contracted condition, loaded as in FIG. 1, when it is desired to discharge the medicament 29 into the digestive tract, or empty as in FIG. 2, when it is desired to have the capsule receive a sample of the fluid in said tract. In use, the capsule is swallowed by the patient and its passage is observed by means of X-rays. When it has reached the desired zone in the digestive tract to be investigated or treated, heat is induced in the body by electrical generation so the capsule is heated sufficient to work on the bellows to cause expansion of the ether and hence the bellows expand to the condition as shown in FIG. 3, whereupon the shells 16 and 17 will move in relation to each other to elongate the envelope they comprise, so the openings 25 and 26 will become communicative. Used in this art to induce the required heat for operation of the capsule, is apparatus creating a high frequency magnetic induction field which raises the temperature of the ferro-magnetic material, which here, is the corrugated tube 23. Said heating apparatus and its manipulations and use, is well known in this art, as well as the use of the X-ray apparatus, so further illustration of explanation thereof is believed unnecessary.

If the capsule used is as in FIG. 1, then the medicament will be discharged by action of the piston 19, into the digestive tract. If the capsule used is as in FIG. 2, a sample of the fluids in the selected zone of the tract, will be free to enter through said valve openings 25, 26, into the space 30. In either case, upon removal of the heat influence, the bellows will contract, whereupon piston movement will cause a sucking in of tract fiuid into the shell 17, which is aided by the slight vacuum caused by the pistons retraction. Later, the spent or laden capsule, as the case may be, is retrieved from the feces. Aid can be had for this, by use of a magnet to attract the capsule, since it bellowss tube 23 is of ferrous material.

The capsule 15, when to be ingested empty as in FIG. 2, for gaining a sample, may be prepared with its interior rarified by vacuum apparatus. This will insure in inrush of tract fluid when the capsule is extended, through the valve openings 25, 26.

Other suitable fillers for the bellows, are acetone, alcohol and methylenechloride.

This invention is capable of numerous forms and various applications without departing from the essential features herein disclosed. It is therefore intended and desired that the embodiments shown herein shall be deemed merely illustrative and not restrictive and that the patent shall cover all patentable novelty herein set forth; reference being had to the following claims rather than to the specific showing herein and the description given, to indicate the scope of this invention.

1. In a swallowable capsule of the character described. an envelope consisting of two shells associated in slidable telescopic relation hole structure in at least one of the shells, so positioned that the interior and exterior of the envelope are non-communicative, and as the shells move to expand the envelope, the opening provides fluid passage means between the interior and exterior of the envelope, a bellows normally in contracted condition, positioned within the envelope; said bellows comprising a longitudinally extensible and contractible tubular member closed by end elements, means securing the ends of said bellows to said shells respectively, so that upon expansion of the bellows, the envelope will expand and then upon contraction of said bellows, said envelope will contract; at least part of said bellows being of a ferrous material adapted to be heated by action of radiant energy generated externally of the capsule; said bellows being filled by a gas which readily expands, causing the bellows to expand, when said radiant energy is applied to influence said ferrous material.

2. A capsule as defined in claim 1, wherein said tubular member of the bellows is a circumferentially corrugated tube, which is longitudinally resilient.

3. A capsule as defined in claim 2, wherein said tube is of steel foil.

4. A capsule as defined in claim 1, wherein one of the shells is a cap on the second shell; said second shell having an end wall closing its month end so that said second shell constitutes a cylinder; the means securing the end element of the bellows to the cap, being a piston rod slidably mounted through said cylinder end wall, and said last mentioned end element of the bellows being a piston slidably fitted in said cylinder; said hole being in the cylinder, near its end wall through which the piston rod is positioned.

5. A capsule as defined in claim 4, wherein said tubular member of the bellows is a circumferentially corrugated tube which is longitudinally resilient.

6. A capsule as defined in claim 4, wherein said tube is of steel foil.

7. A capsule as defined in claim 1, wherein the gas has the expansion and contraction properties of ether when heated and then cooled.

References Cited UNITED STATES PATENTS 3,057,344 10/ 1962; Abella et a1. 128-2 3,118,439 1/1964 Perrenood l28-2 3,315,660 4/1967 Abella 1282 WILLIAM E. KAMM, Primary Examiner US. Cl. X.R. 128260

US3485235A 1967-12-04 1967-12-04 Capsule for the study and treatment of the digestive tract Expired - Lifetime US3485235A (en)

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Cited By (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3608549A (en) * 1970-01-15 1971-09-28 Merrill Edward Wilson Method of administering drugs and capsule therefor
US3659600A (en) * 1970-02-24 1972-05-02 Estin Hans H Magnetically operated capsule for administering drugs
US3692027A (en) * 1971-04-23 1972-09-19 Everett H Ellinwood Jr Implanted medication dispensing device and method
US3786813A (en) * 1972-12-27 1974-01-22 Alza Corp Drug delivery device with self actuated mechanism for retaining device in selected area
US3788322A (en) * 1972-12-27 1974-01-29 Alza Corp Drug delivery device with means for maintaining device in environment of use
US3840009A (en) * 1971-12-27 1974-10-08 Alza Corp Self-powered vapor pressure delivery device
US3894538A (en) * 1972-08-10 1975-07-15 Siemens Ag Device for supplying medicines
US4030499A (en) * 1974-12-30 1977-06-21 Louis Bucalo Method and apparatus for providing living beings with absorbable implants
US4036214A (en) * 1975-04-14 1977-07-19 Louis Bucalo Fluid-collecting and microorganism-detecting devices
FR2374048A1 (en) * 1976-12-20 1978-07-13 Bucalo Louis Liq. collecting probe for insertion into body cavity - has absorbent cotton plug and one way valve with discharge system
WO1979000811A1 (en) * 1978-03-22 1979-10-18 J Pawelec Device for study of the alimentary canal
US4172446A (en) * 1974-12-20 1979-10-30 Louis Bucalo Apparatus for collecting body fluids
US4186730A (en) * 1974-08-23 1980-02-05 Louis Bucalo Methods for collecting body fluids
US4192308A (en) * 1977-10-25 1980-03-11 Alza Corporation Device using prestretched polymer for dispensing medication
US4232673A (en) * 1975-08-11 1980-11-11 Louis Bucalo Method for collecting and processing body fluids
US4257427A (en) * 1973-02-05 1981-03-24 Louis Bucalo Method for collecting body fluids
US4325388A (en) * 1973-02-05 1982-04-20 Louis Bucalo Apparatus for collecting and processing body fluids
US4439197A (en) * 1981-03-23 1984-03-27 Olympus Optical Co., Ltd. Medical capsule device
US4481952A (en) * 1978-03-22 1984-11-13 Jerzy Pawelec Device for the study of the alimentary canal
US4507115A (en) * 1981-04-01 1985-03-26 Olympus Optical Co., Ltd. Medical capsule device
WO1987003465A1 (en) * 1985-12-09 1987-06-18 Alain Lambert Ingestable module for the functional exploration of the digestive tract
US4830855A (en) * 1987-11-13 1989-05-16 Landec Labs, Inc. Temperature-controlled active agent dispenser
US5167626A (en) * 1990-10-02 1992-12-01 Glaxo Inc. Medical capsule device actuated by radio-frequency (RF) signal
US5170801A (en) * 1990-10-02 1992-12-15 Glaxo Inc. Medical capsule device actuated by radio-frequency (rf) signal
US5316015A (en) * 1992-07-30 1994-05-31 Sinaiko Robert J Externally controlled intestinal content sampler
US5819749A (en) * 1995-09-25 1998-10-13 Regents Of The University Of California Microvalve
DE10161958A1 (en) * 2001-12-17 2003-07-03 Universitaetsklinikum Freiburg Surgical system for carrying out a non-invasive or minimal- invasive intervention has a miniature operation capsule that can be inserted in a blood vessel and remotely controlled or moved in a magnetic or electrical field
US20040073018A1 (en) * 1996-11-27 2004-04-15 Gravel Roy A. Human methionine synthase: cloning, and methods for evaluating risk of neural tube defects, cardiovascular disease, and cancer
US20040253304A1 (en) * 2003-01-29 2004-12-16 Yossi Gross Active drug delivery in the gastrointestinal tract
US20040267240A1 (en) * 2003-01-29 2004-12-30 Yossi Gross Active drug delivery in the gastrointestinal tract
US20050058701A1 (en) * 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
US20050075559A1 (en) * 1999-12-21 2005-04-07 Phaeton Research Ltd. Ingestible device
EP1627039A2 (en) * 2003-04-24 2006-02-22 Mark M. Levy Ingestible gastrointestinal device
WO2006041222A3 (en) * 2004-10-15 2006-06-01 Hironao Kawano Body-insertable apparatus for aspirating and expelling body fluid and manufacturing method thereof
US20060276844A1 (en) * 2005-05-19 2006-12-07 Ruth Alon Ingestible device for nitric oxide production in tissue
US20080188837A1 (en) * 2004-12-14 2008-08-07 Ziv Belsky Local Delivery of Drugs or Substances Using Electronic Permeability Increase
US20090318841A1 (en) * 2006-09-18 2009-12-24 Vibrant Ltd. Gastrointestinal capsule
US20100215733A1 (en) * 2004-02-10 2010-08-26 Paolo Costa Device and method for reducing calorie intake
US20100286587A1 (en) * 2009-05-07 2010-11-11 Yossi Gross Sublingual electrical drug delivery
US8414559B2 (en) 2009-05-07 2013-04-09 Rainbow Medical Ltd. Gastroretentive duodenal pill
US8491495B1 (en) * 2012-11-16 2013-07-23 L. Zane Shuck Human intestinal tract research and diagnostic system to evaluate patients and advance medical science and bioengineering and to determine processes in the gut and causes of diseases
US20140162305A1 (en) * 2012-11-30 2014-06-12 L. Zane Shuck Patient In Vivo Gut Diagnostic and Treatment Tool
US20140163416A1 (en) * 2012-11-16 2014-06-12 L. Zane Shuck In Vivo Device and Method for Researching GI Tract Processes, Microbes, and Variables Associated with Illnesses and Diseases
WO2014140334A1 (en) * 2013-03-15 2014-09-18 Mars, Incorporated Sampling device
US20150112166A1 (en) * 2012-11-16 2015-04-23 L. Zane Shuck In Vivo Technology System for Human Gut Research, Diagnostics and Treatment
US9320715B2 (en) 2011-03-29 2016-04-26 Slendine Sa Devices and methods for weight control and weight loss

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3057344A (en) * 1957-05-21 1962-10-09 Abella Carlos Alberto Capsule for the study of the digestive tract and method of using the same
US3118439A (en) * 1957-04-09 1964-01-21 Perrenoud Jean-Pierre Diagnostic and medicating capsule and the method of use
US3315660A (en) * 1963-08-08 1967-04-25 Carlos A Abella Capsule for insertion in the digestive track

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3118439A (en) * 1957-04-09 1964-01-21 Perrenoud Jean-Pierre Diagnostic and medicating capsule and the method of use
US3057344A (en) * 1957-05-21 1962-10-09 Abella Carlos Alberto Capsule for the study of the digestive tract and method of using the same
US3315660A (en) * 1963-08-08 1967-04-25 Carlos A Abella Capsule for insertion in the digestive track

Cited By (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3608549A (en) * 1970-01-15 1971-09-28 Merrill Edward Wilson Method of administering drugs and capsule therefor
US3659600A (en) * 1970-02-24 1972-05-02 Estin Hans H Magnetically operated capsule for administering drugs
US3692027A (en) * 1971-04-23 1972-09-19 Everett H Ellinwood Jr Implanted medication dispensing device and method
US3840009A (en) * 1971-12-27 1974-10-08 Alza Corp Self-powered vapor pressure delivery device
US3894538A (en) * 1972-08-10 1975-07-15 Siemens Ag Device for supplying medicines
US3786813A (en) * 1972-12-27 1974-01-22 Alza Corp Drug delivery device with self actuated mechanism for retaining device in selected area
US3788322A (en) * 1972-12-27 1974-01-29 Alza Corp Drug delivery device with means for maintaining device in environment of use
US4325388A (en) * 1973-02-05 1982-04-20 Louis Bucalo Apparatus for collecting and processing body fluids
US4257427A (en) * 1973-02-05 1981-03-24 Louis Bucalo Method for collecting body fluids
US4186730A (en) * 1974-08-23 1980-02-05 Louis Bucalo Methods for collecting body fluids
US4172446A (en) * 1974-12-20 1979-10-30 Louis Bucalo Apparatus for collecting body fluids
US4030499A (en) * 1974-12-30 1977-06-21 Louis Bucalo Method and apparatus for providing living beings with absorbable implants
US4036214A (en) * 1975-04-14 1977-07-19 Louis Bucalo Fluid-collecting and microorganism-detecting devices
US4232673A (en) * 1975-08-11 1980-11-11 Louis Bucalo Method for collecting and processing body fluids
FR2374048A1 (en) * 1976-12-20 1978-07-13 Bucalo Louis Liq. collecting probe for insertion into body cavity - has absorbent cotton plug and one way valve with discharge system
US4192308A (en) * 1977-10-25 1980-03-11 Alza Corporation Device using prestretched polymer for dispensing medication
WO1979000811A1 (en) * 1978-03-22 1979-10-18 J Pawelec Device for study of the alimentary canal
US4481952A (en) * 1978-03-22 1984-11-13 Jerzy Pawelec Device for the study of the alimentary canal
US4439197A (en) * 1981-03-23 1984-03-27 Olympus Optical Co., Ltd. Medical capsule device
US4507115A (en) * 1981-04-01 1985-03-26 Olympus Optical Co., Ltd. Medical capsule device
WO1987003465A1 (en) * 1985-12-09 1987-06-18 Alain Lambert Ingestable module for the functional exploration of the digestive tract
US4830855A (en) * 1987-11-13 1989-05-16 Landec Labs, Inc. Temperature-controlled active agent dispenser
US5167626A (en) * 1990-10-02 1992-12-01 Glaxo Inc. Medical capsule device actuated by radio-frequency (RF) signal
US5170801A (en) * 1990-10-02 1992-12-15 Glaxo Inc. Medical capsule device actuated by radio-frequency (rf) signal
US5316015A (en) * 1992-07-30 1994-05-31 Sinaiko Robert J Externally controlled intestinal content sampler
US5819749A (en) * 1995-09-25 1998-10-13 Regents Of The University Of California Microvalve
US20040073018A1 (en) * 1996-11-27 2004-04-15 Gravel Roy A. Human methionine synthase: cloning, and methods for evaluating risk of neural tube defects, cardiovascular disease, and cancer
US7282045B2 (en) 1999-12-21 2007-10-16 Phaeton Research Ltd. Ingestible device
US20050075559A1 (en) * 1999-12-21 2005-04-07 Phaeton Research Ltd. Ingestible device
US7763014B2 (en) 1999-12-21 2010-07-27 Phaeton Research Ltd. Ingestible device
DE10161958A1 (en) * 2001-12-17 2003-07-03 Universitaetsklinikum Freiburg Surgical system for carrying out a non-invasive or minimal- invasive intervention has a miniature operation capsule that can be inserted in a blood vessel and remotely controlled or moved in a magnetic or electrical field
US20040253304A1 (en) * 2003-01-29 2004-12-16 Yossi Gross Active drug delivery in the gastrointestinal tract
US20050058701A1 (en) * 2003-01-29 2005-03-17 Yossi Gross Active drug delivery in the gastrointestinal tract
US20040267240A1 (en) * 2003-01-29 2004-12-30 Yossi Gross Active drug delivery in the gastrointestinal tract
EP1627039A4 (en) * 2003-04-24 2012-11-07 Mark M Levy Ingestible gastrointestinal device
EP1627039A2 (en) * 2003-04-24 2006-02-22 Mark M. Levy Ingestible gastrointestinal device
US9724306B2 (en) 2004-02-10 2017-08-08 Slendine Ag Device and method for reducing calorie intake
US9220688B2 (en) * 2004-02-10 2015-12-29 Slendine Sa Device and method for reducing calorie intake
US20100215733A1 (en) * 2004-02-10 2010-08-26 Paolo Costa Device and method for reducing calorie intake
WO2006041222A3 (en) * 2004-10-15 2006-06-01 Hironao Kawano Body-insertable apparatus for aspirating and expelling body fluid and manufacturing method thereof
CN101039715B (en) 2004-10-15 2011-12-07 奥林巴斯株式会社 May be inserted into the body of device and manufacturing method
US8038646B2 (en) 2004-10-15 2011-10-18 Olympus Corporation Body-insertable apparatus and manufacturing method thereof
US20080188837A1 (en) * 2004-12-14 2008-08-07 Ziv Belsky Local Delivery of Drugs or Substances Using Electronic Permeability Increase
US20060276844A1 (en) * 2005-05-19 2006-12-07 Ruth Alon Ingestible device for nitric oxide production in tissue
US20090318841A1 (en) * 2006-09-18 2009-12-24 Vibrant Ltd. Gastrointestinal capsule
EP2073779A4 (en) * 2006-09-18 2016-07-20 Vibrant Ltd Gastrointestinal capsule
US9078799B2 (en) * 2006-09-18 2015-07-14 Vibrant Ltd. Gastrointestinal capsule
US20100286587A1 (en) * 2009-05-07 2010-11-11 Yossi Gross Sublingual electrical drug delivery
US8414559B2 (en) 2009-05-07 2013-04-09 Rainbow Medical Ltd. Gastroretentive duodenal pill
US9320715B2 (en) 2011-03-29 2016-04-26 Slendine Sa Devices and methods for weight control and weight loss
US8915863B2 (en) * 2012-11-16 2014-12-23 L. Zane Shuck In vivo device and method for researching GI tract processes, microbes, and variables associated with illnesses and diseases
US20150112166A1 (en) * 2012-11-16 2015-04-23 L. Zane Shuck In Vivo Technology System for Human Gut Research, Diagnostics and Treatment
US20140163416A1 (en) * 2012-11-16 2014-06-12 L. Zane Shuck In Vivo Device and Method for Researching GI Tract Processes, Microbes, and Variables Associated with Illnesses and Diseases
US9215997B2 (en) * 2012-11-16 2015-12-22 L. Zane Shuck In vivo technology system for human gut research, diagnostics and treatment
US8491495B1 (en) * 2012-11-16 2013-07-23 L. Zane Shuck Human intestinal tract research and diagnostic system to evaluate patients and advance medical science and bioengineering and to determine processes in the gut and causes of diseases
US8926526B2 (en) * 2012-11-30 2015-01-06 L. Zane Shuck Patient in vivo gut diagnostic and treatment tool
US20140162305A1 (en) * 2012-11-30 2014-06-12 L. Zane Shuck Patient In Vivo Gut Diagnostic and Treatment Tool
CN105050500A (en) * 2013-03-15 2015-11-11 马斯公司 The sampling device
WO2014140334A1 (en) * 2013-03-15 2014-09-18 Mars, Incorporated Sampling device

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