CN109745079B - Small intestine liquid extractor - Google Patents
Small intestine liquid extractor Download PDFInfo
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- CN109745079B CN109745079B CN201910033445.2A CN201910033445A CN109745079B CN 109745079 B CN109745079 B CN 109745079B CN 201910033445 A CN201910033445 A CN 201910033445A CN 109745079 B CN109745079 B CN 109745079B
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- 239000007788 liquid Substances 0.000 title abstract description 22
- 210000000813 small intestine Anatomy 0.000 title abstract description 22
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 48
- 230000000968 intestinal effect Effects 0.000 claims abstract description 47
- 239000002775 capsule Substances 0.000 claims abstract description 43
- 230000006835 compression Effects 0.000 claims abstract description 18
- 238000007906 compression Methods 0.000 claims abstract description 18
- 239000000463 material Substances 0.000 claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 8
- 229920000642 polymer Polymers 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 3
- 235000014633 carbohydrates Nutrition 0.000 claims description 3
- 150000001720 carbohydrates Chemical class 0.000 claims description 3
- 238000005187 foaming Methods 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 229920006238 degradable plastic Polymers 0.000 claims description 2
- 238000005520 cutting process Methods 0.000 claims 1
- 238000004080 punching Methods 0.000 claims 1
- 210000004051 gastric juice Anatomy 0.000 abstract description 4
- 238000007789 sealing Methods 0.000 abstract description 3
- 238000010923 batch production Methods 0.000 abstract 1
- 230000001079 digestive effect Effects 0.000 description 7
- 210000001035 gastrointestinal tract Anatomy 0.000 description 5
- 210000001198 duodenum Anatomy 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 210000003405 ileum Anatomy 0.000 description 3
- 210000001630 jejunum Anatomy 0.000 description 3
- 210000003041 ligament Anatomy 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000000436 anus Anatomy 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000001072 colon Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 210000003238 esophagus Anatomy 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 241000167880 Hirundinidae Species 0.000 description 1
- 229910000861 Mg alloy Inorganic materials 0.000 description 1
- 229910001297 Zn alloy Inorganic materials 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001839 endoscopy Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000004018 waxing Methods 0.000 description 1
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Abstract
The embodiment of the invention provides a small intestinal juice extractor. The invention provides a small intestinal juice extractor comprising: a capsule-shaped inner shell, a capsule-shaped outer shell, a compression spring-sponge complex, an arc-shaped clamping piece and an enteric capsule shell; the compression spring-sponge complex is assembled inside the capsule-shaped inner shell; the capsule-shaped inner shell, the capsule-shaped outer shell and the arc-shaped clamping sheet are assembled into a complete capsule framework; the enteric capsule skin wraps the complete capsule skeleton. The capsule small intestine liquid extractor has the advantages of simple structure, convenient assembly, low cost and convenient batch production. The capsule has better sealing performance, and the small intestinal juice specimen is prevented from being polluted by large intestinal juice and gastric juice. The inner shell, the outer shell and the spring are made of degradable materials, so that the inner shell, the outer shell and the spring can be slowly degraded, and the safety of the small intestinal juice extractor is improved.
Description
Technical Field
The invention relates to the technical field of medical appliance manufacturing, in particular to a small intestinal juice extractor.
Background
The digestive tract of human body is divided into esophagus, stomach, duodenum, jejunum, ileum, colon and rectum, and digestive juice in the digestive tract is an important specimen for diagnosing digestive tract diseases. At present, digestive juice above the ligament of stomach, esophagus and duodenum can be obtained by a gastroscope, and digestive juice of colon and rectum can be obtained by a colonoscope. However, the enteroscope has high requirements on equipment and operation technology, and the enteroscope itself wastes time and labor, so that the digestive juice acquisition of duodenum, jejunum and ileum below the ligament of flexor does not have a simple and convenient method yet to be widely popularized in clinic.
Various capsule endoscopes are used for acquiring imaging data of small intestine (including duodenum, jejunum and ileum under the flexor ligament), and are widely applied in clinic at present. However, capsule endoscopy can only obtain imaging data, and is difficult to obtain a sample in the small intestine for testing. Capsule robots are a means being developed for gastrointestinal specimen acquisition, but are not yet in clinical use at present and are necessarily cost-intensive. It is known that some capsule liquid extractors are used for collecting intestinal juice samples in research, and the principle is that a patient swallows the liquid extractor, after the liquid extractor reaches the small intestine, an opening on a shell of the capsule liquid extractor is opened to extract the intestinal juice, and then the opening is closed, so that the liquid extractor is discharged through an anus to obtain the intestinal juice in a physiological state. However, the various small intestine liquid taking devices at present have the defects of small liquid taking amount, poor sample quality, high cost, unstable performance, complex production flow and the like, and the small intestine liquid taking devices which completely meet the clinical requirements are not used on a large scale.
Although the prior technical scheme can solve the problem that the small intestinal juice extractor is opened and closed at a fixed point in the small intestine, the space for storing the collected small intestinal juice is not provided with a material for keeping the small intestinal juice, so that the situation that the small intestinal juice collected before the switch of the extractor is closed is lost due to gastrointestinal peristalsis cannot be avoided. In addition, the existing small intestinal juice extractor is complex to assemble and is not beneficial to large-scale production. Therefore, there is a need to provide a small intestinal juice extractor to solve the problems of complicated structure, high cost, multiple production and assembly processes and unstable juice extraction amount of the existing small intestinal juice extractor.
Disclosure of Invention
An object of this application is to provide a small intestine liquid extractor, solves current small intestine liquid extractor structure too complicated, and is with high costs, and the production assembly flow is many and get the unstable problem of liquid volume.
To achieve the above object, the present application provides a small intestinal fluid extractor, which in one embodiment includes: a capsule-shaped inner shell, a capsule-shaped outer shell, a compression spring-sponge complex, an arc-shaped clamping piece and an enteric capsule shell; the compression spring-sponge complex is assembled inside the capsule-shaped inner shell; the capsule-shaped inner shell, the capsule-shaped outer shell and the arc-shaped clamping sheet are assembled into a complete capsule framework; the enteric capsule skin wraps the complete capsule skeleton.
Furthermore, the side wall of the capsule-shaped shell is provided with at least two groups of arc-shaped openings; the arc-shaped openings comprise a first opening, a second opening and a third opening, and the first opening, the second opening and the third opening are sequentially arranged in the axial middle of the capsule-shaped shell according to the sequence of the first opening, the second opening and the third opening.
Furthermore, the side wall of the capsule-shaped inner shell is provided with at least two groups of arc-shaped openings, and the number of the arc-shaped openings is consistent with that of the arc-shaped openings of the capsule-shaped outer shell; the arcuate openings of the inner capsule shell are coincident with the outer capsule shell at circumferentially opposite locations of the interface.
Furthermore, the materials of the inner capsule-shaped shell and the outer capsule-shaped shell are slow degradable plastics.
Further, the arc-shaped cards comprise a first arc-shaped card and a second arc-shaped card; the first arc-shaped card is an arc-shaped solid made of digestible starch polymer or carbohydrate or protein polymer; the first arc-shaped clamping piece is matched with the first opening, and the first arc-shaped clamping piece can be inserted into the first opening; the second arc-shaped clamping piece is consistent with the capsule-shaped inner shell or the capsule-shaped outer shell in material; the second arc-shaped clamping piece is matched with the third opening, and the second arc-shaped clamping piece can be inserted into the third opening.
Further, the compression spring-sponge complex is produced integrally, namely the compression spring is placed in a foaming system for sponge production, and the sponge is cut or punched and formed after being formed; the spring is made of degradable metal.
Therefore, the capsule small intestinal juice extractor provided by the invention solves the problems that the existing small intestinal juice extractor is too complex in structure, high in cost, multiple in production and assembly processes and unstable in liquid taking amount. The capsule has better sealing performance, and the small intestinal juice specimen is prevented from being polluted by large intestinal juice and gastric juice. The inner shell, the outer shell and the spring are made of degradable materials, so that the inner shell, the outer shell and the spring can be slowly degraded, and the safety of the small intestinal juice extractor is improved.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
FIG. 1 is a schematic view of the capsule shell structure of the present invention;
FIG. 2 is a schematic view of the construction of the inner capsule shell of the present invention;
FIG. 3 is a schematic view of the arc-shaped fastener of the present invention;
FIG. 4 is a schematic diagram of the structure of the spring-sponge complex of the present invention;
FIG. 5 is a schematic diagram of the structure of an enteric capsule shell of the present invention;
FIG. 6 is a schematic view of the combination of the small intestine fluid extractor of the present invention;
fig. 7 is a schematic view showing a closed state of the small intestinal juice extractor of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In order to solve the problems that the existing small intestinal juice extractor is too complex in structure, high in cost, multiple in production and assembly processes and unstable in liquid taking amount, the invention adopts the technical scheme that: the invention provides a small intestinal juice extractor, comprising: a capsule-shaped inner shell 001, a capsule-shaped outer shell 002, a compression spring-sponge complex 003, an enteric capsule shell 004, a first arc-shaped card 005 and a second arc-shaped card 006; the compression spring-sponge complex 003 is fitted inside the capsule-shaped inner shell 001; the capsule-shaped inner shell 001, the capsule-shaped outer shell 002 and the arc-shaped card are assembled into a complete capsule framework; the enteric capsule shell 004 wraps the complete capsule framework to form the small intestinal juice extractor.
In the above technical solution, a more specific solution is: the side wall of the capsule shell 002 is provided with at least two groups of arc openings; the arc-shaped openings include a first opening 007, a second opening 008 and a third opening 009, and the first opening 007, the second opening 008 and the third opening 009 are sequentially arranged in the order of the first opening 007, the second opening 008 and the third opening 009 in the axial middle of the capsule-shaped shell 002.
Furthermore, the side wall of the capsule-shaped inner shell 001 is provided with at least two groups of arc-shaped openings, and the number of the arc-shaped openings is consistent with that of the arc-shaped openings of the capsule-shaped outer shell; the arcuate openings of the inner capsule shell 001 coincide with the outer capsule shell 002 at opposite locations of the interface circumference.
Further, the arc cards include a first arc card 005 and a second arc card 006; the first arc-shaped card 005 is an arc-shaped solid made of digestible starch polymer or carbohydrate or protein polymer; the first arc-shaped clamping piece 005 is matched with the first opening 007, and the first arc-shaped clamping piece 005 can be inserted into the first opening 007; when the human body small intestine digestive juice is contacted with the human body small intestine digestive juice at about 38 ℃, the mechanical strength is lost in about half an hour, and the human body small intestine digestive juice is basically dissolved in 2 hours. The second arc-shaped card 006 is made of the same material as the capsule-shaped inner shell 001 or the capsule-shaped outer shell 002; the second arc-shaped card 006 is matched with the third opening 009, and the second arc-shaped card 006 can be inserted into the third opening 009.
The compression spring-sponge complex 003 is produced integrally, namely, the compression spring is placed in a foaming system for sponge production, and the sponge is cut or punched and formed after being formed so as to ensure that sponge materials are filled in the spring and gaps; the spring is made of degradable metal (such as magnesium alloy or zinc alloy, but not limited thereto), and can be slowly degraded in the intestinal tract of a human body.
The spring is specially manufactured aiming at the capsule framework, namely, the spring is formed by connecting two side shafts between springs with the same length at two ends.
In order to enhance the tightness between the inner shell and the outer shell, the outer side surface of the inner wall needs to be specially waxed before assembly.
The waxing material is prepared by mixing powdery high-molecular water-absorbing resin (SAP) and paraffin according to a certain proportion.
The small intestinal juice extractor is assembled, wherein the compression spring-sponge complex 003 is assembled inside the capsule-shaped inner shell 001, then the capsule-shaped inner shell 002, the first arc-shaped clamping piece 005 and the second arc-shaped clamping piece 006 are assembled into a complete capsule framework, and finally the enteric capsule skin is coated on the complete capsule framework to form the small intestinal juice extractor.
The small intestinal juice extractor can be discharged along with excrement under normal conditions, but if the small intestinal juice extractor is stuck in the gastrointestinal tract and is taken out without intervention of a doctor, the small intestinal juice extractor can be slowly degraded because the small intestinal juice extractor is made of degradable materials.
The specific implementation mode is as follows: the extractor was assembled as in fig. 6 before use. A first digestible arcuate snap 005 is mounted to the first opening 007 of each set of openings and a second arcuate snap 006 is mounted to the third opening 009 of each set of openings. At this time, the inner spring is in a compressed state, and the first arc-shaped latch 005 fixes the capsule-shaped inner shell 001 so that it is not ejected out of the outer shell by the spring. The enteric capsule shell 004 is sleeved on the small intestinal juice extractor framework to seal the second opening 008, so that gastric juice can be prevented from entering the capsule. When the small intestine liquid extractor is used, a patient takes the small intestine liquid extractor down, and the second opening 008 is in a closed state before the small intestine liquid extractor reaches the small intestine due to the wrapping of the enteric capsule shell 004. When the intestinal fluid reaches the small intestine, the enteric capsule shell outside the intestinal fluid extractor disintegrates under the action of the intestinal fluid, and the second opening 008 is exposed. At this point, intestinal fluid may seep into the sponge inside the extractor through the second opening 008. At the moment, the first arc-shaped clamping piece 005 is gradually digested and dissolved due to the contact with the small intestinal juice until the inner shell cannot be fixed, so that the inner shell moves to the state 2 (figure 7) under the action of the spring, and at the moment, the capsule-shaped inner shell 001 is fixed due to the action of the second arc-shaped clamping piece 006, so that the capsule-shaped outer shell 002 cannot be ejected out; and the inner shell sidewall just closes the outer shell first 007 and second 008 openings so that surrounding liquid no longer enters the small intestine liquid extractor. Finally, after the small intestinal juice extractor is discharged from the anus, the sponge with the small intestinal juice in the inner part is taken out to be used as a subsequent inspection item.
Compared with the prior art, the invention has the following beneficial effects: the compression spring-sponge 003 is produced integrally and is placed in the inner shell, and the small intestine liquid holding device has the advantages of convenient installation and capability of keeping a fixed volume: the small intestinal juice is not easy to lose. The capsule has better sealing performance, and the small intestinal juice specimen is prevented from being polluted by large intestinal juice and gastric juice. The capsule-shaped inner shell 001 and the capsule-shaped outer shell 002 have simple structures, are convenient to produce and assemble, and are convenient for large-scale low-cost production. The capsule-shaped inner shell 001, the capsule-shaped outer shell 002 and the spring are made of degradable materials, so that the capsule-shaped inner shell, the capsule-shaped outer shell 002 and the spring can be slowly degraded, and the safety of the small intestinal juice extractor is improved.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (3)
1. A small intestinal fluid extractor, comprising: a capsule-shaped inner shell, a capsule-shaped outer shell, a compression spring-sponge complex, an arc-shaped card and an enteric capsule shell;
the compression spring-sponge complex is assembled in the capsule-shaped inner shell, the compression spring-sponge complex is produced integrally, and the spring is formed by connecting two side shafts between springs with the same length at two ends;
the capsule-shaped inner shell, the capsule-shaped outer shell and the arc-shaped clamping sheet are assembled into a complete capsule framework;
the side wall of the capsule-shaped shell is provided with at least two groups of arc-shaped openings; the arc-shaped openings comprise a first opening, a second opening and a third opening, and the first opening, the second opening and the third opening are sequentially arranged in the axial middle of the capsule-shaped shell according to the sequence of the first opening, the second opening and the third opening;
the side wall of the capsule-shaped inner shell is provided with at least two groups of arc-shaped openings, and the number of the arc-shaped openings is consistent with that of the arc-shaped openings of the capsule-shaped outer shell; the arc-shaped openings of the capsule-shaped inner shell are consistent with the capsule-shaped outer shell at the opposite positions of the interface circumference; the arc-shaped cards comprise a first arc-shaped card and a second arc-shaped card; the first arc-shaped card is an arc-shaped solid made of digestible starch polymer or carbohydrate or protein polymer; the first arc-shaped clamping piece is matched with the first opening, and the first arc-shaped clamping piece can be inserted into the first opening; the second arc-shaped clamping piece is consistent with the capsule-shaped inner shell or the capsule-shaped outer shell in material; the second arc-shaped clamping piece is matched with the third opening, and the second arc-shaped clamping piece can be inserted into the third opening;
the enteric capsule skin wraps the complete capsule skeleton.
2. The intestinal fluid extractor of claim 1, wherein the inner and outer capsule shells are made of a slowly degradable plastic.
3. The small intestinal juice extractor of claim 1, wherein the compression spring-sponge complex is produced integrally by placing the compression spring in a foaming system for sponge production, and cutting or punching the compression spring after the sponge is formed; the spring is made of degradable metal.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910033445.2A CN109745079B (en) | 2019-01-14 | 2019-01-14 | Small intestine liquid extractor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910033445.2A CN109745079B (en) | 2019-01-14 | 2019-01-14 | Small intestine liquid extractor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109745079A CN109745079A (en) | 2019-05-14 |
| CN109745079B true CN109745079B (en) | 2021-10-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201910033445.2A Active CN109745079B (en) | 2019-01-14 | 2019-01-14 | Small intestine liquid extractor |
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| Country | Link |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112043313B (en) * | 2020-08-31 | 2022-08-09 | 深圳市泓云润泽医疗科技有限公司 | Auxiliary assembly device for small intestinal juice extractor |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3485235A (en) * | 1967-12-04 | 1969-12-23 | Ronald Felson | Capsule for the study and treatment of the digestive tract |
| US4481952A (en) * | 1978-03-22 | 1984-11-13 | Jerzy Pawelec | Device for the study of the alimentary canal |
| US4960134A (en) * | 1988-11-18 | 1990-10-02 | Webster Wilton W Jr | Steerable catheter |
| US5217449A (en) * | 1990-12-11 | 1993-06-08 | Miyarisan Kabushiki Kaisha | Medical capsule and apparatus for activating the same |
| US6013052A (en) * | 1997-09-04 | 2000-01-11 | Ep Technologies, Inc. | Catheter and piston-type actuation device for use with same |
| CN2605868Y (en) * | 2003-01-24 | 2004-03-10 | 陈为民 | Miniature digestive canal sampler |
| CN201719267U (en) * | 2010-06-08 | 2011-01-26 | 重庆金山科技（集团）有限公司 | Alimentary canal body fluid micro-collecting device |
| CN103285491A (en) * | 2012-02-29 | 2013-09-11 | 四川锦江电子科技有限公司 | Controllable electrophysiologic conduit |
| WO2018213729A1 (en) * | 2017-05-19 | 2018-11-22 | Tidhar Shalon | Devices and methods for collecting gastrointestinal samples |
-
2019
- 2019-01-14 CN CN201910033445.2A patent/CN109745079B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3485235A (en) * | 1967-12-04 | 1969-12-23 | Ronald Felson | Capsule for the study and treatment of the digestive tract |
| US4481952A (en) * | 1978-03-22 | 1984-11-13 | Jerzy Pawelec | Device for the study of the alimentary canal |
| US4960134A (en) * | 1988-11-18 | 1990-10-02 | Webster Wilton W Jr | Steerable catheter |
| US5217449A (en) * | 1990-12-11 | 1993-06-08 | Miyarisan Kabushiki Kaisha | Medical capsule and apparatus for activating the same |
| US6013052A (en) * | 1997-09-04 | 2000-01-11 | Ep Technologies, Inc. | Catheter and piston-type actuation device for use with same |
| CN2605868Y (en) * | 2003-01-24 | 2004-03-10 | 陈为民 | Miniature digestive canal sampler |
| CN201719267U (en) * | 2010-06-08 | 2011-01-26 | 重庆金山科技（集团）有限公司 | Alimentary canal body fluid micro-collecting device |
| CN103285491A (en) * | 2012-02-29 | 2013-09-11 | 四川锦江电子科技有限公司 | Controllable electrophysiologic conduit |
| WO2018213729A1 (en) * | 2017-05-19 | 2018-11-22 | Tidhar Shalon | Devices and methods for collecting gastrointestinal samples |
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| CN109745079A (en) | 2019-05-14 |
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Effective date of registration: 20210928 Address after: 615099 No. 37, group 7, Tuanjie village, Gaojian Township, Xichang City, Liangshan Yi Autonomous Prefecture, Sichuan Province Applicant after: Zhang Zhixiu Address before: 459000 county level administrative division directly under the central government of Henan Province room 801, unit 6, building 9, community 818, Jingliang North Street, Jiyuan City Applicant before: Li Yuying |
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Effective date of registration: 20220118 Address after: 518100 R & D building 440, Founder science and Technology Industrial Park, north of Songbai highway, Longteng community, Shiyan street, Bao'an District, Shenzhen, Guangdong Patentee after: Shenzhen Hongyun Runze Medical Technology Co.,Ltd. Address before: 615099 No. 37, group 7, Tuanjie village, Gaojian Township, Xichang City, Liangshan Yi Autonomous Prefecture, Sichuan Province Patentee before: Zhang Zhixiu |