US3399536A - Device for varying the blood temperature - Google Patents

Device for varying the blood temperature Download PDF

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Publication number
US3399536A
US3399536A US612849A US61284967A US3399536A US 3399536 A US3399536 A US 3399536A US 612849 A US612849 A US 612849A US 61284967 A US61284967 A US 61284967A US 3399536 A US3399536 A US 3399536A
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Prior art keywords
blood
flow
space
varying
temperature
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Expired - Lifetime
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US612849A
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English (en)
Inventor
Walz Heinz
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Siemens AG
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Siemens AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/44—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
    • F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
    • F25B21/00—Machines, plants or systems, using electric or magnetic effects
    • F25B21/02—Machines, plants or systems, using electric or magnetic effects using Peltier effect; using Nernst-Ettinghausen effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3606—General characteristics of the apparatus related to heating or cooling cooled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/3673—General characteristics of the apparatus related to heating or cooling thermo-electric, e.g. Peltier effect, thermocouples, semi-conductors

Definitions

  • Arism'er har s mscrbs'uiie -'I-he blood' tem-perature varying "device has-"abandshaped flow-through space extending across substantially the entire s'urface'on one 'side' of -a'Peltier'block.
  • the space has a width manytimes greater than-the thickness thereof and is provided with an inlet and an outlet "at the extremities thereof.
  • The-space has fan-shaped transition portions "respectively outwardly flaring from and inwardly narrowing to the inlet and outlet andiscurved substantially in accordance with the stream lines of blood I flowing through the space. Furthermore, the spaceis defined by smoothly polished surfaces.
  • My invention relates to device for varying the 'blood temperature and more particularly a device of; that type which employs a Peltier block connected on the warm side thereof with cooling 'fins' and onjth'e cold side there 'gfwitha flow-through cooler actingas a heat. exchanger, both thecooling fins andthe flow-through cooler being thermally conductive with and electrically insulated from the Peltier block.
  • Modern-surgical operating practice has sought for a long itime' to carry out anl operation underhypothermal conditions wherein the. temperature of the field of the operation is lowered toa v lue bel wjgso1o Under-such subcooled'cond ition, the ox gen, Iequirement'and this me ho i 'oi all tisf u fi s re u t ai aq a ex en and ;-the supply, of oxygenfto the e'sl Consequently rcfn'g no m-3 .3 m 'adt fi-lr j rrb uc L ofsubcooling in the lieldlof the operation, it has already been known to reducethe tempef'ature of the entire body, For this purpose, thebody i'sf 'cooled" from the eitterior thereof with ice packs, coolant" coils or coolingmats J traversed by a cooling liquid.
  • An extracorporeal circulation .system ,or loop portion has to be provided by means of which blood is tapped only from the artery-supplying the 3,399,536 Patented Sept.' 3 1968 fieldof the operation and, after being cooled, is re turned'to this artery.
  • a flow-through cooler which is connected 'intothe extracorporeal portion of the circulation system presents itself as a suitable't'echnical solution of this problem. From the medical point of view, several technicalrequirements must be imposed upon these flowthroug'h coolers. The flow through the'cooler must take place without any congestion or obstruction in blind corners' thereof, in order to prevent coagulat'ion of-the blood. Microscopically.
  • the blood temperature must be maintained as constant as possible after the blood has passed the cooler flow-th'rough stage. Therefore, the occurrence of temperature gradients within the flow 'as it'passes through the cooling stage must be avoided as much as possible.
  • the flow-through space in the cooler must be well scaled to prevent the occurrence of interchange processes between the blood and the surroundings.
  • the material from which the flow-through cooler is made must be corrosion-resistant, capable of sterilization and boilable. 7
  • a device for varying the blood temperature which comprises means having a flowthrough space extending in the shape of a band across substantially the entire surface on one side of a Peltier block and having a width many times greater than the thickness thereof and an outlet from and an' inlet to the flow-through space.
  • the flow-through space has 'a fanshaped transition portion respectively flaring" outwardly from the inlet and narrowing toward the outlet.
  • the transition portion is curved substantially in accordance with the stream lines of blood flowing through the space.
  • the space is defined by surfaces that are smoothly polished.
  • the cooled blood flowing back from the field of the operation or at least a portion thereof is conducted into a second extracorporeal circulating system adjacent the warm side of the block so as to reheat it at that location.
  • the temperature of the entire body thus remains practically independent of the subcooling of the field of the operation. Consequently, in accordance with this further feature of my invention, there is provided a second heat exchanger, with a flow-through space having the aforementioned features, at the warm side of the Peltier block, in the place of at least part of the cooling fins, for heating the blood.
  • the heat exchangers are made of corrosion-resistant metal; furthermore, the flow-through space in each heat exchanger is sealed by means of a sealing member or gasket resistant to boiling, and the heat exchangers are removable. Also in accordance with a feature of my invention, I provide a regulating device which assures a specific constant temperature of the blood after it has passed through the flowthrough stage.
  • FIG. 1 is a diagrammatic longitudinal view partly in section of an embodiment of the device for varying the blood temperature constructed in accordance with my invention
  • FIG. 2 is a plan view of FIG. 1 with the cover plate on the right-hand side of FIG. I removed;
  • FIG. 3 is another diagrammatic longitudinal sectional view of a second embodiment of the device of FIG. 1;
  • FIG. 4 is a diagrammatic view of an extracorporeal portion of a blood circulating system in which the device of my invention is connected;
  • FIG. 5 is a diagrammatic view of two extracorporeal portions of'circulating systems in which my device is connected.
  • FIGS. 1 and 2 there is shown a Peltier block formed of pand n-conductive semiconductor members 1, contact bridges 2 therebetween and heat exchanger plates 3. Cooling fins 10 are superimposed on the heat exchanger plate 3 at the'warm side of the Peltier block and are ventilated by a fan 11 to remove the heat therefrom.
  • a heat exchanger 4 is mounted on the heat-exchanger plate 3 at the 'cold side of the Peltier block and is provided with a flow-through space 6 that is closed by a cover plate 5, suitably secured thereon.
  • the flow-through space 6 is provided with an inlet opening 7 and an outlet opening 8 at the extremities thereof.
  • the flow-through space is sealed by a gasket 9.
  • the heat exchanger of FIG. 1 is shown with the cover 5 removed.
  • the cooling fins 10 of the embodiment of FIG. 1 are replaced by a second heat exchanger.
  • the second heat exchanger comprises a main plate 4,, a flow-through space 6', an inlet and an outletopening 7' and 8' respectively, and a cover plate 5' substantially of the same construction and function as the corresponding members of the first-mentioned heat exchanger of the embodiment of FIG. 1.
  • FIG. 4 schematically shows an extracorporeal portion of ablood circulation system in which the device of my invention is inserted.
  • the artery 10 is interrupted at a location 13 and the blood from the artery 10 is conducted through a bypass tube 11 to the device 12 for cooling the blood.
  • the bypass tube 11 can be made of suitable plastic material.
  • the device 12 of my invention for cooling the blood corresponds to the device shown in greater detail in-FIGS. 1 and 2 and described hereinbefore.
  • the blood flows from the portion of the artery 10, located at the left-hand side of FIG. 4, through the band-shaped flow-through space of the cooling device 12 and is returned to the artery 10 portion at the right-hand side of FIG. '4. In the field of the oper-j ation, a temperature reduction to about 15 C. is obtained thereby.
  • FIG. 5 there are shown two extracorporeal portions of a blood circulating system.
  • the first portion of the blood circulating system is tapped with the bypass tube 11 from the artery 10 which supplies the field 15,- having the capillary vessels 16, :wherein the surgical operation is to be performed.
  • a device 14 constructed in accordance with my invention for cooling the blood.
  • the device 14 corresponds to the embodiment shown in FIG. 3 in detail, wherein a second flow-through cooler or heat exchanger for reheating the blood is superposed on the warm side of the Peltier block.
  • the blood is conducted through a bypass tube 18 out of a portion of a vein 17 which is broken at a location 19, and is returned after flowing through the device 14 to the vein 17 at the righthand side of FIG. 5.
  • the blood flowing back from the field of the operation or at least a portion thereof is reheated before it is returned to the circulation system proper of the body. The occurrence of damage to the entire organism due to subcooling of a field of an operation need no longer be feared when using this device of my invention.
  • Device for varying blood temperature comprising a Peltier block having a warm side and a cold side, a flow-through heat exchanger connected to one of said sides of'said Peltier block in thermal conduction therewith and electrically insulated therefrom, said heat exchanger having a flow-through space traversible .by a flow of blood, said space extending band-shaped over substantially,the entire area of the Peltier block on one of.
  • said sides thereof and having a width many times greater than the thickness thereof, and a blood inlet to and outlet from said flow-through space located at extremities thereof, said space being defined by smoothly polished surfaces and having fan-shaped transition portions respectively flaring from said inlet and narrowing to said outlet, said flow-through space having corners that are all rounded in outline, and said fan-shaped portions being defined by lateral surface at the flaring sides thereof having a given degree of inclination cooperating with said rounded corners for avoiding stagnation of blood flowing through said space.
  • Blood-temperature varying device wherein said flow-through heat exchanger is connected to said cold side of said Peltier block, and cooling fins are connected to the warm side of said Peltier block in heat conductive and electrically insulating contact therewith.
  • Blood-temperature varying device including a second flow-through heat exchanger substantially similar to said first-mentioned heat exchanger and being similarly connected to the other side of said Peltier block.

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Mechanical Engineering (AREA)
  • Thermal Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • External Artificial Organs (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
US612849A 1966-02-02 1967-01-31 Device for varying the blood temperature Expired - Lifetime US3399536A (en)

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DES0101757 1966-02-02

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BE (1) BE693048A (US20100012521A1-20100121-C00001.png)
CH (1) CH460064A (US20100012521A1-20100121-C00001.png)
DE (1) DE1501134B2 (US20100012521A1-20100121-C00001.png)
FR (1) FR1509763A (US20100012521A1-20100121-C00001.png)
GB (1) GB1110638A (US20100012521A1-20100121-C00001.png)
NL (1) NL6700243A (US20100012521A1-20100121-C00001.png)

Cited By (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4248259A (en) * 1977-05-16 1981-02-03 Packard Instrument Company, Inc. Fluid flow control device
US4473739A (en) * 1980-12-18 1984-09-25 Helmholtz-Institut Fur Biomedizinische Technik Process and apparatus for warming of suspensions or solutions frozen in a flat plastic bag
US4782212A (en) * 1986-11-17 1988-11-01 Bakke Allan P Electric blood warmer utilizing a metallic ribbon-flow cartridge
US4847470A (en) * 1987-12-14 1989-07-11 Bakke Allan P Electric blood warmer utilizing metallic ribbon flow cartridge and low thermal mass heating units
WO1992017040A1 (en) * 1991-03-15 1992-10-01 In-Touch Products Co. Parenteral fluid warmer cassette, system and methods
FR2678512A1 (fr) * 1991-07-03 1993-01-08 Novacell Machine a internaliser.
US5181382A (en) * 1991-08-02 1993-01-26 Middlebrook Thomas F Heating/cooling or warming stage assembly with coverslip chamber assembly and perfusion fluid preheater/cooler assembly
US5381510A (en) * 1991-03-15 1995-01-10 In-Touch Products Co. In-line fluid heating apparatus with gradation of heat energy from inlet to outlet
EP0653215A1 (en) * 1993-07-12 1995-05-17 Otsuka Pharmaceutical Factory, Inc. Cooler for blood plasma cooling bags
US5564276A (en) * 1995-02-24 1996-10-15 United Defense, L.P. Micro-climate conditioning unit
US5584183A (en) * 1994-02-18 1996-12-17 Solid State Cooling Systems Thermoelectric heat exchanger
US5613364A (en) * 1995-10-06 1997-03-25 Pou, Inc. Compact replaceable temperature control module
WO1997034647A1 (en) * 1996-03-18 1997-09-25 Medtronic, Inc. Blood oxygenator with waterless heat exchanger
US5846224A (en) * 1996-10-01 1998-12-08 Baxter International Inc. Container for use with blood warming apparatus
US6047108A (en) * 1996-10-01 2000-04-04 Baxter International Inc. Blood warming apparatus
US6175688B1 (en) 1998-07-10 2001-01-16 Belmont Instrument Corporation Wearable intravenous fluid heater
US6755026B2 (en) * 2002-10-24 2004-06-29 Tech Medical Devices Inc. Thermoelectric system to directly regulate the temperature of intravenous solutions and bodily fluids
ES2264347A1 (es) * 2004-10-04 2006-12-16 Calor Hospitalario, S.L. Dispositivo para regular la temperatura de un fluido fisiologico.
WO2007068767A1 (es) * 2005-12-15 2007-06-21 Laboratorios CAIR España, S.L. Dispositivo para regular la temperatura de un fluido fisiológico
US20080156476A1 (en) * 2005-03-17 2008-07-03 Smisson-Cartledge Biomedical Llc Heat Exchange System For A Pump Device
US20100030137A1 (en) * 2005-02-14 2010-02-04 Optiscan Biomedical Corporation Apparatus and methods for analyzing body fluid samples
WO2012019693A1 (de) * 2010-07-20 2012-02-16 Fresenius Medical Care Deutschland Gmbh Anordnung zum erwärmen eines medizinischen fluids, medizinische funktionseinrichtung, medizinische behandlungsvorrichtung und verfahren
CN101547830B (zh) * 2006-11-09 2013-02-13 空中客车德国运营有限责任公司 用于安装在飞机中的冷却设备
US8828068B2 (en) 2007-07-17 2014-09-09 Cardiac Pacemakers, Inc. Systems and methods for local vasoactive response using temperature modulation
US9737672B2 (en) 2007-08-07 2017-08-22 Belmont Instrument Corporation Hyperthermia, system, method, and components
US20170276402A1 (en) * 2016-03-23 2017-09-28 Wwt Technischer Geraetebau Gmbh Modular Blood Warmer
US9863837B2 (en) 2013-12-18 2018-01-09 OptiScan Biomedical Coporation Systems and methods for detecting leaks
US10137257B2 (en) 2016-11-30 2018-11-27 Belmont Instrument, Llc Slack-time heating system for blood and fluid warming
US10475529B2 (en) 2011-07-19 2019-11-12 Optiscan Biomedical Corporation Method and apparatus for analyte measurements using calibration sets
US10485936B2 (en) 2016-11-30 2019-11-26 Belmont Instrument, Llc Rapid infuser with advantageous flow path for blood and fluid warming
US10507292B2 (en) 2016-11-30 2019-12-17 Belmont Instrument, Llc Rapid infuser with vacuum release valve
US11000407B2 (en) 2007-08-07 2021-05-11 Belmont Instrument, Llc Hyperthermia, system, method, and components
US11077020B2 (en) 2013-05-07 2021-08-03 Biosafe S.A. Fluid processing based on inflatable bags, mixing system, and method of use thereof

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* Cited by examiner, † Cited by third party
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DE2808473C2 (de) * 1978-02-28 1982-12-30 Hellige Gmbh, 7800 Freiburg Medizinisch-diagnostische Vorrichtung zur Bestimmung von Blutungszeit und Blutungsverhalten
FR2505294A1 (fr) * 1981-05-11 1982-11-12 Extracorporeal Med Spec Appareil pour chauffer ou refroidir des fluides et recipient utilisable dans cet appareil
DE3639089A1 (de) * 1986-11-14 1988-05-26 Unitechnica Mobilkaelte Gmbh Thermoelektrische kuehlvorrichtung
GB2252815B (en) * 1991-02-14 1995-10-04 Dyson John Newlyn Improvements in or relating to cooling apparatus
DE102006004756B4 (de) * 2005-07-29 2015-10-15 Herbert Wolf Peltier-Wärmeaustauscher in modularer Bauweise
ITMO20050243A1 (it) * 2005-09-23 2007-03-24 Rand Srl Sistema per il monitoraggio della circolazione extracorporea e la perfusione di flussi medicali durante interventi di bypass cardiopolmonare
CN113251692B (zh) * 2021-07-13 2021-09-10 苏州维嘉科技股份有限公司 半导体控温装置和使用其的自动光学检测设备

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US3008300A (en) * 1959-04-09 1961-11-14 Carrier Corp Thermoelectric apparatus for heating or cooling of fluids
US3137141A (en) * 1962-04-19 1964-06-16 Halsey W Taylor Company Thermoelectric water coolers
US3238944A (en) * 1962-10-08 1966-03-08 Max L Hirschhorn Temperature controlling device for living organs
US3293868A (en) * 1965-02-16 1966-12-27 Medical Electroscience Inc Fluid cooling apparatus

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US286219A (en) * 1883-10-09 Frederic b
US3006979A (en) * 1959-04-09 1961-10-31 Carrier Corp Heat exchanger for thermoelectric apparatus
US3008300A (en) * 1959-04-09 1961-11-14 Carrier Corp Thermoelectric apparatus for heating or cooling of fluids
US3137141A (en) * 1962-04-19 1964-06-16 Halsey W Taylor Company Thermoelectric water coolers
US3238944A (en) * 1962-10-08 1966-03-08 Max L Hirschhorn Temperature controlling device for living organs
US3293868A (en) * 1965-02-16 1966-12-27 Medical Electroscience Inc Fluid cooling apparatus

Cited By (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4248259A (en) * 1977-05-16 1981-02-03 Packard Instrument Company, Inc. Fluid flow control device
US4473739A (en) * 1980-12-18 1984-09-25 Helmholtz-Institut Fur Biomedizinische Technik Process and apparatus for warming of suspensions or solutions frozen in a flat plastic bag
US4782212A (en) * 1986-11-17 1988-11-01 Bakke Allan P Electric blood warmer utilizing a metallic ribbon-flow cartridge
US4847470A (en) * 1987-12-14 1989-07-11 Bakke Allan P Electric blood warmer utilizing metallic ribbon flow cartridge and low thermal mass heating units
US5381510A (en) * 1991-03-15 1995-01-10 In-Touch Products Co. In-line fluid heating apparatus with gradation of heat energy from inlet to outlet
US5245693A (en) * 1991-03-15 1993-09-14 In-Touch Products Co. Parenteral fluid warmer apparatus and disposable cassette utilizing thin, flexible heat-exchange membrane
WO1992017040A1 (en) * 1991-03-15 1992-10-01 In-Touch Products Co. Parenteral fluid warmer cassette, system and methods
FR2678512A1 (fr) * 1991-07-03 1993-01-08 Novacell Machine a internaliser.
WO1993000940A1 (fr) * 1991-07-03 1993-01-21 Novacell Appareil pour faire penetrer des medicaments dans des globules rouges
US5589389A (en) * 1991-07-03 1996-12-31 Fondation Nationale De Transfusion Sanguine Apparatus for causing medicinal products to penetrate into red blood cells
US5181382A (en) * 1991-08-02 1993-01-26 Middlebrook Thomas F Heating/cooling or warming stage assembly with coverslip chamber assembly and perfusion fluid preheater/cooler assembly
EP0653215A1 (en) * 1993-07-12 1995-05-17 Otsuka Pharmaceutical Factory, Inc. Cooler for blood plasma cooling bags
EP0653215A4 (en) * 1993-07-12 1998-04-22 Otsuka Pharma Co Ltd COOLER FOR BLOOD PLASMA COOLER.
US5584183A (en) * 1994-02-18 1996-12-17 Solid State Cooling Systems Thermoelectric heat exchanger
US5564276A (en) * 1995-02-24 1996-10-15 United Defense, L.P. Micro-climate conditioning unit
US5613364A (en) * 1995-10-06 1997-03-25 Pou, Inc. Compact replaceable temperature control module
WO1998043026A1 (en) * 1995-10-06 1998-10-01 Pou, Inc. Compact replaceable temperature control module
WO1997034647A1 (en) * 1996-03-18 1997-09-25 Medtronic, Inc. Blood oxygenator with waterless heat exchanger
US6045752A (en) * 1996-03-18 2000-04-04 Medtronic, Inc. Blood oxygenator with waterless heat exchanger
US5846224A (en) * 1996-10-01 1998-12-08 Baxter International Inc. Container for use with blood warming apparatus
US6047108A (en) * 1996-10-01 2000-04-04 Baxter International Inc. Blood warming apparatus
US6175688B1 (en) 1998-07-10 2001-01-16 Belmont Instrument Corporation Wearable intravenous fluid heater
US6236809B1 (en) 1998-07-10 2001-05-22 Belmont Instrument Corporation Wearable intravenous fluid heater
US6480257B2 (en) 1998-07-10 2002-11-12 Belmont Instrument Corporation Heat exchanger useable in wearable fluid heater
US6755026B2 (en) * 2002-10-24 2004-06-29 Tech Medical Devices Inc. Thermoelectric system to directly regulate the temperature of intravenous solutions and bodily fluids
ES2264347A1 (es) * 2004-10-04 2006-12-16 Calor Hospitalario, S.L. Dispositivo para regular la temperatura de un fluido fisiologico.
US20100030137A1 (en) * 2005-02-14 2010-02-04 Optiscan Biomedical Corporation Apparatus and methods for analyzing body fluid samples
US20080156476A1 (en) * 2005-03-17 2008-07-03 Smisson-Cartledge Biomedical Llc Heat Exchange System For A Pump Device
US7975491B2 (en) * 2005-03-17 2011-07-12 Smisson-Cartledge Biomedical Llc Heat exchange system for a pump device
WO2007068767A1 (es) * 2005-12-15 2007-06-21 Laboratorios CAIR España, S.L. Dispositivo para regular la temperatura de un fluido fisiológico
US20090056344A1 (en) * 2005-12-15 2009-03-05 Jaime Arbos Poch Device for adjusting the temperature of a physiological fluid
US7841189B2 (en) 2005-12-15 2010-11-30 Laboratorios Cair Espana, S.L. Device for adjusting the temperature of a physiological fluid
CN101547830B (zh) * 2006-11-09 2013-02-13 空中客车德国运营有限责任公司 用于安装在飞机中的冷却设备
US8828068B2 (en) 2007-07-17 2014-09-09 Cardiac Pacemakers, Inc. Systems and methods for local vasoactive response using temperature modulation
US9737672B2 (en) 2007-08-07 2017-08-22 Belmont Instrument Corporation Hyperthermia, system, method, and components
US11000407B2 (en) 2007-08-07 2021-05-11 Belmont Instrument, Llc Hyperthermia, system, method, and components
US9285137B2 (en) 2010-07-20 2016-03-15 Fresenius Medical Care Deutschland Gmbh Arrangement for heating a medical fluid, medical functional device, medical treatment apparatus and method
WO2012019693A1 (de) * 2010-07-20 2012-02-16 Fresenius Medical Care Deutschland Gmbh Anordnung zum erwärmen eines medizinischen fluids, medizinische funktionseinrichtung, medizinische behandlungsvorrichtung und verfahren
US10475529B2 (en) 2011-07-19 2019-11-12 Optiscan Biomedical Corporation Method and apparatus for analyte measurements using calibration sets
US11077020B2 (en) 2013-05-07 2021-08-03 Biosafe S.A. Fluid processing based on inflatable bags, mixing system, and method of use thereof
US11918541B2 (en) 2013-05-07 2024-03-05 Biosafe S.A. Fluid processing based on inflatable bags, mixing system, and method of use thereof
US9863837B2 (en) 2013-12-18 2018-01-09 OptiScan Biomedical Coporation Systems and methods for detecting leaks
US20170276402A1 (en) * 2016-03-23 2017-09-28 Wwt Technischer Geraetebau Gmbh Modular Blood Warmer
US10921021B2 (en) * 2016-03-23 2021-02-16 Wwt Technischer Geraetebau Gmbh Modular blood warmer
US10137257B2 (en) 2016-11-30 2018-11-27 Belmont Instrument, Llc Slack-time heating system for blood and fluid warming
US10485936B2 (en) 2016-11-30 2019-11-26 Belmont Instrument, Llc Rapid infuser with advantageous flow path for blood and fluid warming
US10507292B2 (en) 2016-11-30 2019-12-17 Belmont Instrument, Llc Rapid infuser with vacuum release valve
US11872382B2 (en) 2016-11-30 2024-01-16 Belmont Instrument, Llc Rapid infuser with advantageous flow path for blood and fluid warming, and associated components, systems, and methods

Also Published As

Publication number Publication date
DE1501134B2 (de) 1976-08-12
DE1501134A1 (de) 1969-10-23
CH460064A (de) 1968-07-31
BE693048A (US20100012521A1-20100121-C00001.png) 1967-07-03
GB1110638A (en) 1968-04-24
FR1509763A (fr) 1968-01-12
NL6700243A (US20100012521A1-20100121-C00001.png) 1967-08-03

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