US3252331A - Laboratory apparatus - Google Patents

Laboratory apparatus Download PDF

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Publication number
US3252331A
US3252331A US410421A US41042164A US3252331A US 3252331 A US3252331 A US 3252331A US 410421 A US410421 A US 410421A US 41042164 A US41042164 A US 41042164A US 3252331 A US3252331 A US 3252331A
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US
United States
Prior art keywords
liquid
cage
entrapping
transfer device
annular surface
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US410421A
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English (en)
Inventor
Jesse F Lancaster
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cooke Engineering Co
Original Assignee
Cooke Engineering Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cooke Engineering Co filed Critical Cooke Engineering Co
Priority to US410421A priority Critical patent/US3252331A/en
Application granted granted Critical
Publication of US3252331A publication Critical patent/US3252331A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0244—Drop counters; Drop formers using pins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0244—Drop counters; Drop formers using pins
    • B01L3/0255—Drop counters; Drop formers using pins characterized by the form or material of the pin tip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F19/00—Calibrated capacity measures for fluids or fluent solid material, e.g. measuring cups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/12—Dippers; Dredgers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces

Definitions

  • This invention relates to laboratory apparatus and, more specifically, to improvements in liquid transfer devices or dilution loops which may be advantageously used with microtitration apparatus of the type disclosed in copending application SerialNo. 135,364 filed August 31, 1961, by Alan A. Duff et al.
  • Such wire wound loops have the disadvantage in that they are very diflicult if not impossible to wind with a precise volumetric capacity so that each loop must be individually inspected and calibrated, if not within specified tolerances, before it is delivered to the customer for use.
  • wire wound loops are relatively fragile in that their configuration can be permanently deformed if they are dropped or even if roughly laid on a worktable so that it is necessary to frequently check the calibration of the loops and discard or recalibrate the loops which are not in calibration.
  • the delicate construction of these loops thus results in increased time and expense in manufacture, loss of time in use and relatively short life.
  • the heretofore proposed alternatives to wire loops have not found acceptance commercially for various reasons.
  • the principal objects of the present invention are to provide a liquid transfer device or dilution loop which:
  • FIGURE 1 is a full size drawing of a liquid transfer device constructed in accord with the present invention and constituting the preferred embodiment thereof;
  • FIGURE 2 is an enlarged view of the lower end of the device of FIGURE 1;
  • FIGURE 3 is a bottom view of the structure of FIG- URE 2;
  • FIGURE 4 is a full scale view of a liquid transfer de vice in accord with the present invention showing an alternative construction
  • FIGURE 5 is an enlarged view of the lower end of the A liquid transfer device of FIGURE 4.
  • FIGURE 6 is a bottom view of the structure of FIG- URE 5;
  • FIGURE 7 is an enlarged view of the lower end of a further form of liquid transfer device constructed in accord with the present invention.
  • FIGURE 8 is a sectional view taken substantially along the line 8--8 of FIGURE 7.
  • the liquid transfer device 10 comprises an elongated handle 12 and a one-piece head 14 consisting 'of an elongated shank 16 and a liquid entrapping cage 18.
  • the upper end of the shank 16 extends within an aperture 20 formed coaxially in the lower end of the handle 12.
  • the upper end of shank 16 is fixed within the aperture 20 either by a forced fit or by any other suitable means establishing a substantially permanent connection between the head 14 and the handle 12.
  • the head 14 is of one-piece construction being formed from cylindrical stock on a screw machine or other suitable conventional machining equipment.
  • the shank 16 is preferably cylindrical.
  • the liquid entrapping cage has an external cylindrical wall 22, a frustoconical wall 24 extending between the upper end of the wall 22 and the shank 16, a frustoconical surface 26 providing a slight bevel at the lower end of the cylindrical wall 22, and a planar bottom surface 28.
  • the surfaces 22, 24, 26 and the shank 16 are preferably all coaxial and coaxial with the axis of the handle 12.
  • the liquid entrapping cage has a central chamber 30 x which is opened through the bottom surface 28 and a plurality of radiating passages 32 extending from the chamber 30 preferably radially outwardly through the surfaces 22 and 26. In the illustrated embodiment there are eight passages 32.
  • the passages 32 and the central chamber 30 are formed by making four diametral cuts through the liquid entrapping cage material 18, the volumetric capacity of the cage 18 being determined by the width of the cuts and the depth of the cuts from the surface 28.
  • the resultant volumetric capacity of the liquid entrapping cage 18 can be accurately predetermined so that, so long as the parts are made to specified tolerances,
  • the diameter of the surface 28 may be .120 inch-003 inch, the diameter of the surface 22 .155 inch plus .002 inch minus .000 inch, the cha'mfer provided by the surface 26, 45 degrees, the width of the passages 32 .016 inch plus .002 inch minus .000 inch, the axial length of the surface 22 .170 inch-1:005 inch and the depths of. the passages 32 axially of the liquid entrapping cage 18 .158 inch plus .002 inch minus .000 inch.
  • the head 14 is formed of type 321 stainless steel. This material is designed for high temperature chemical handling equipment. It has a high titanium content for extra corrosion resistance and has excellent resistance'to scaling at high temperatures. After the head 14 has been machined, it is passivated to remove all foreign particles on its surfaces due to tool erosion during the machining process. It is then annealed to eliminate magnetism caused by cold working of the material. The head is then etched in a solution of one part nitric acid and three parts hydrochloric acid for a period of time sufficient to produce a satin finish.
  • a satin finish formed in this manner has been found to improve the pickup characteristics of the liquid entrapping cage so that only slight immersion of the lower end of the liquid entrapping cage 18 in the liquid is required for the chamber 30 and the passages 32 to become completely filled with the liquid by capillary attraction.
  • the exterior surfaces of the liquid entrapping cage 18 are electroplated with a very thin coating of gold, known as gold flash. This coating is primarily to improve the appearance of the unit without producing any deleterious effect upon its liquid pickup and discharge characteristics or its ability to withstand substantially indefinitely the effect of corrosive fluids and high temperatures as required for sterilization and use.
  • the liquid entrapping cage 18 can be calibrated by slight bending of the portions of the liquid entrapping cage 18 lying between one or more adjacent pairs of passages 32 radially inwardly toward the chamber 30 or radially outwardly.
  • a plate which has a row of liquid receptacles or cups in which is deposited equal volumes of a first liquid, the liquid transfer device is filled with a second liquid, and then successively immersed and rotated within the liquid in each cup in the row to thereby form progressive dilutions of the second liquid.
  • the construction of the present invention facilitates this action in that as the liquid transfer device is rotated within the liquid in a given cup, the liquid entrapping cage 18 functions as a centrifugal impeller or pump having an axial inlet at the bottom through the surface 28 directly into the chamber 30 and radial outlets through the passages 32.
  • the upper end of the chamber 30 is co-planar with the upper ends of the passages 32 so that there are no pockets wiithin the passages 32 or the chamber 30 in which liquid is retained or trapped. This assures that all of the liquid within the liquid entrapping cage 18 is thoroughly mixed with the diluent.
  • FIGURES 4, 5 and 6 is in all respects identical with the embodiment described above in reference to FIGURES 1, 2 and 3 except that a hemispherical or conoidal surface 34 is provided at the lower end of the liquid entrap-ping cage 36 in lieu of the bevel 26 and the planar surface 23.
  • This hemispherical or conoidal surface 34 is preferable for certain applications such as where the bottom or end wall of the cup or receptacles of the microtitration plates is of hemispherical or conoidal form in that it permits the bottom end of the liquid entrapping cage to touch the bottom of the cup or receptacle and fully drain the liquid content thereof whereas in certain situations, the flat surface 28 of the liquid entrapping cage 18 may preclude this.
  • FIGURES 1, 2 and 3 is preferred however to that of FIGURES 4, 5 and 6 because this requirement is very infrequently encountered and the design of FIG- UR'ES 1, 2 and 3 is generally more rugged and less susceptible of deformation from calibration by rough handling in use.
  • FIGURES 7 and 8 illustrate a still further embodiment of the present invention.
  • This embodiment consists of a handle 38 and a head 40.
  • the head 40 is of one-piece construction consisting of a shank 42 and a liquid entrapping cage 44.
  • the cage 44 has a single diametral slot 46 intersectedby a diametrally extending cylindrical through passage 48. While this liquid transfer device functions generally satisfactorily, it is less satisfactory than those of the first two embodiments in that liquid pickup is not as rapid and in that, with certain liquids, difficulty has been found from time to time in assuring complete drainage of the liquid from all of the interior passages.
  • a volumetric liquid transfer device comprising a rigid one-piece liquid entrapping cage for carrying a liquid having a surface tension, said cage having an exterior configuration including an axially elongated annular surface portion and end surfaces at opposite ends of said annular surface portion which are symmetrical with the axis of symmetry of said annular surface portion and in which the portion of said cage defined by said annular surface portion and at least one of said end surfaces is provided with a central chamber extending axially from and through said one end surface and a plurality of capillary channels communicating with and radiating from the chamber of said cage, the size of each such capillary channel being not greater than that which will retain said liquid in said cage by surface tension.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Hydrology & Water Resources (AREA)
  • Fluid Mechanics (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Centrifugal Separators (AREA)
  • Details Of Rigid Or Semi-Rigid Containers (AREA)
  • Measurement Of Radiation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
US410421A 1964-11-23 1964-11-23 Laboratory apparatus Expired - Lifetime US3252331A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US410421A US3252331A (en) 1964-11-23 1964-11-23 Laboratory apparatus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US410421A US3252331A (en) 1964-11-23 1964-11-23 Laboratory apparatus
GB50254/64A GB1121659A (en) 1964-12-10 1964-12-10 Improved liquid sampling device

Publications (1)

Publication Number Publication Date
US3252331A true US3252331A (en) 1966-05-24

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Family Applications (2)

Application Number Title Priority Date Filing Date
US410421A Expired - Lifetime US3252331A (en) 1964-11-23 1964-11-23 Laboratory apparatus
US510585A Expired - Lifetime US3363468A (en) 1964-12-10 1965-11-30 Liquid sampling device

Family Applications After (1)

Application Number Title Priority Date Filing Date
US510585A Expired - Lifetime US3363468A (en) 1964-12-10 1965-11-30 Liquid sampling device

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US (2) US3252331A (enrdf_load_stackoverflow)
CH (1) CH448571A (enrdf_load_stackoverflow)
DE (1) DE1598080B2 (enrdf_load_stackoverflow)
FR (1) FR1457933A (enrdf_load_stackoverflow)
GB (2) GB234220A (enrdf_load_stackoverflow)
NL (1) NL6515933A (enrdf_load_stackoverflow)
SE (1) SE313938B (enrdf_load_stackoverflow)

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3363468A (en) * 1964-12-10 1968-01-16 Blades Alfred Nigel Liquid sampling device
US3466153A (en) * 1966-08-12 1969-09-09 Metrimpex Magyar Mueszeripari Appliance for use in chemical analysis
US3474674A (en) * 1966-02-17 1969-10-28 Precision Sampling Corp Liquid injection apparatus
US3757584A (en) * 1972-03-13 1973-09-11 Linbro Chemical Co Inc Diluter for laboratory titration
US3797318A (en) * 1971-08-10 1974-03-19 Bodenseewerk Perkin Elmer Co Method and apparatus for collecting and introducing a sample into an analytical instrument
DE2827484A1 (de) 1977-06-21 1979-02-01 Minnesota Mining & Mfg Vorrichtung und verfahren zum zuechten von bakterien
US4162896A (en) * 1977-03-09 1979-07-31 Institut Pasteur Micro-analysis process and device
US4252904A (en) * 1979-01-22 1981-02-24 Minnesota Mining And Manufacturing Company Bacteria growing device
US4309912A (en) * 1980-08-01 1982-01-12 Smith Kendall O Micro-analysis process and device
US4345028A (en) * 1979-01-22 1982-08-17 Minnesota Mining And Manufacturing Company Bacteria growing device
US4687746A (en) * 1984-01-20 1987-08-18 Ramot University Authority For Applied Research And Industrial Development Ltd. Microorganism culture-transfer device
FR2623283A1 (fr) * 1987-11-13 1989-05-19 Guigan Jean Dispositif pour delivrer une dose predeterminee d'un liquide
US4862753A (en) * 1988-11-23 1989-09-05 Millipore Corporation Probe tip apparatus
EP0385602A1 (en) * 1989-02-13 1990-09-05 Minnesota Mining And Manufacturing Company Device for obtaining predetermined amounts of bacteria
WO1997018036A1 (en) * 1995-11-13 1997-05-22 Cortecs (Uk) Limited Diagnostic test apparatus
US5770151A (en) * 1996-06-05 1998-06-23 Molecular Dynamics, Inc. High-speed liquid deposition device for biological molecule array formation
USD412990S (en) 1996-10-07 1999-08-17 Cortecs (Uk) Limited Medical test device
DE19933838A1 (de) * 1999-07-20 2001-02-01 Max Planck Gesellschaft Nadel und Verfahren zum Transfer von Liquiden sowie Verfahren zum Herstellen der Nadel
US20020094304A1 (en) * 2000-12-22 2002-07-18 Tom Yang High speed liquid deposition apparatus for microarray fabrication
US20040037748A1 (en) * 2002-08-23 2004-02-26 Leila Hasan Voltage-aided transfer pins
US20040191924A1 (en) * 1998-01-12 2004-09-30 Massachusetts Institute Of Technology Reformatted through-hole arrays
US20060094108A1 (en) * 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
US7049102B1 (en) 1989-09-22 2006-05-23 Board Of Trustees Of Leland Stanford University Multi-gene expression profile
US20070003448A1 (en) * 2004-03-12 2007-01-04 Kanigan Tanya S Nanoliter array loading
US20070116604A1 (en) * 2000-12-12 2007-05-24 Brenneman Allen J Optical sensor
US20080299600A1 (en) * 2005-08-02 2008-12-04 Bommarito G Marco Apparatus Assembly and Method for Detecting an Analyte
US20090012425A1 (en) * 2005-08-02 2009-01-08 Dodge Larry H Apparatus and Method for Collecting a Sample of Material
US20090019953A1 (en) * 2005-08-02 2009-01-22 3 Innovative Properties Company Apparatus And Method For Detecting An Analyte
US20090030342A1 (en) * 2007-07-27 2009-01-29 3M Innovative Properties Company Apparatus and method for releasing a sample of material
US7604983B2 (en) 2000-02-18 2009-10-20 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
WO2009134509A3 (en) * 2008-02-15 2010-01-14 3M Innovative Properties Company Sample acquisition device
US7666360B2 (en) 1999-03-19 2010-02-23 Biotrove, Inc. Multi-through hole testing plate for high throughput screening
US7682565B2 (en) 2002-12-20 2010-03-23 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
US20100300769A1 (en) * 2007-11-13 2010-12-02 Lars Sodan Connecting element
US20110179887A1 (en) * 2008-02-15 2011-07-28 Cobian Paul J Sample acquisition device
CN102576031A (zh) * 2009-06-02 2012-07-11 因福皮亚有限公司 采样/样本注射装置以及包括其的生物数据测量套件
US20170113216A1 (en) * 2015-05-03 2017-04-27 Clear Labs Inc. Apparatus and method for economic, fast and easy sampling of food and environmental samples
US11376580B2 (en) * 2017-10-30 2022-07-05 University of Pittsburgh—of the Commonwealth System of Higher Education Methods and systems comprising modified pipettes for transferring and preserving biomaterial
CN116165015A (zh) * 2022-02-16 2023-05-26 佳木斯大学 一种含有收集接柱的基于混凝土生产中的粉料取样设备

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US3191813A (en) * 1962-04-23 1965-06-29 Cooke Engineering Company Laboratory apparatus
US4362621A (en) * 1981-04-27 1982-12-07 Merck & Co., Inc. Radial flow cell
GB8528155D0 (en) * 1985-11-14 1985-12-18 Ici Plc Sampling device
US4933291A (en) * 1986-12-22 1990-06-12 Eastman Kodak Company Centrifugable pipette tip and pipette therefor
FR2668592A1 (fr) * 1990-10-26 1992-04-30 Icauna Dispositif perfectionne pour prelever et deposer une dose predeterminee de liquide.
FR2678379B1 (fr) * 1991-06-28 1993-09-03 Guigan Jean Dispositif pour prelever et restituer une quantite predeterminee d'un liquide.
DE10239739B4 (de) * 2002-08-29 2006-05-11 Leica Mikrosysteme Gmbh Vorrichtung und Verfahren zur Durchführung von immunologischen Markierungstechniken für Gewebedünnschnitte
FR3048775B1 (fr) * 2016-03-10 2019-12-06 Biomerieux Systeme et procede de melange automatique de solutions

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GB234220A (en) * 1964-12-10 1925-05-28 Stanley Joseph William Charlto Improved means for measuring quantities or doses of granular or powdered materials

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Cited By (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3363468A (en) * 1964-12-10 1968-01-16 Blades Alfred Nigel Liquid sampling device
US3474674A (en) * 1966-02-17 1969-10-28 Precision Sampling Corp Liquid injection apparatus
US3466153A (en) * 1966-08-12 1969-09-09 Metrimpex Magyar Mueszeripari Appliance for use in chemical analysis
US3797318A (en) * 1971-08-10 1974-03-19 Bodenseewerk Perkin Elmer Co Method and apparatus for collecting and introducing a sample into an analytical instrument
US3757584A (en) * 1972-03-13 1973-09-11 Linbro Chemical Co Inc Diluter for laboratory titration
US4162896A (en) * 1977-03-09 1979-07-31 Institut Pasteur Micro-analysis process and device
DE2858340C2 (enrdf_load_stackoverflow) * 1977-06-21 1991-03-21 Minnesota Mining & Mfg. Co., Saint Paul, Minn., Us
DE2827484A1 (de) 1977-06-21 1979-02-01 Minnesota Mining & Mfg Vorrichtung und verfahren zum zuechten von bakterien
US4252904A (en) * 1979-01-22 1981-02-24 Minnesota Mining And Manufacturing Company Bacteria growing device
US4345028A (en) * 1979-01-22 1982-08-17 Minnesota Mining And Manufacturing Company Bacteria growing device
US4309912A (en) * 1980-08-01 1982-01-12 Smith Kendall O Micro-analysis process and device
US4687746A (en) * 1984-01-20 1987-08-18 Ramot University Authority For Applied Research And Industrial Development Ltd. Microorganism culture-transfer device
EP0316698A1 (fr) * 1987-11-13 1989-05-24 Jean Guigan Dispositif pour délivrer une dose prédéterminée d'un liquide
US4874114A (en) * 1987-11-13 1989-10-17 Jean Guigan Device for dispensing a predetermined quantity of a liquid
FR2623283A1 (fr) * 1987-11-13 1989-05-19 Guigan Jean Dispositif pour delivrer une dose predeterminee d'un liquide
US4862753A (en) * 1988-11-23 1989-09-05 Millipore Corporation Probe tip apparatus
EP0385602A1 (en) * 1989-02-13 1990-09-05 Minnesota Mining And Manufacturing Company Device for obtaining predetermined amounts of bacteria
US7049102B1 (en) 1989-09-22 2006-05-23 Board Of Trustees Of Leland Stanford University Multi-gene expression profile
WO1997018036A1 (en) * 1995-11-13 1997-05-22 Cortecs (Uk) Limited Diagnostic test apparatus
US6241689B1 (en) 1995-11-13 2001-06-05 Provalis Uk Limited Diagnostic test apparatus
US5770151A (en) * 1996-06-05 1998-06-23 Molecular Dynamics, Inc. High-speed liquid deposition device for biological molecule array formation
USD412990S (en) 1996-10-07 1999-08-17 Cortecs (Uk) Limited Medical test device
USD426313S (en) * 1996-10-07 2000-06-06 Cortecs (Uk) Limited Collector portion for a medical test device
US20040191924A1 (en) * 1998-01-12 2004-09-30 Massachusetts Institute Of Technology Reformatted through-hole arrays
US8029745B2 (en) 1998-01-12 2011-10-04 Massachusetts Institute Of Technology Systems for filling a sample array by droplet dragging
US7666360B2 (en) 1999-03-19 2010-02-23 Biotrove, Inc. Multi-through hole testing plate for high throughput screening
US10195579B2 (en) 1999-03-19 2019-02-05 Life Technologies Corporation Multi-through hole testing plate for high throughput screening
EP1207960B1 (de) * 1999-07-20 2004-01-07 Deutsches Ressourcenzentrum für Genomforschung GmbH Nadel und verfahren zum transfer von liquiden sowie verfahren zum herstellen der nadel
DE19933838A1 (de) * 1999-07-20 2001-02-01 Max Planck Gesellschaft Nadel und Verfahren zum Transfer von Liquiden sowie Verfahren zum Herstellen der Nadel
US10378049B2 (en) 2000-02-18 2019-08-13 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of microvolume liquid reactions
US8906618B2 (en) 2000-02-18 2014-12-09 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US9518299B2 (en) 2000-02-18 2016-12-13 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US7604983B2 (en) 2000-02-18 2009-10-20 Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of micro-volume liquid reactions
US10227644B2 (en) 2000-02-18 2019-03-12 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and methods for parallel processing of microvolume liquid reactions
US20070116604A1 (en) * 2000-12-12 2007-05-24 Brenneman Allen J Optical sensor
US20020094304A1 (en) * 2000-12-22 2002-07-18 Tom Yang High speed liquid deposition apparatus for microarray fabrication
WO2002051549A3 (en) * 2000-12-22 2003-07-24 Amersham Biosciences Sv Corp High speed liquid deposition apparatus for microarray fabrication
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
US20090054266A1 (en) * 2002-08-23 2009-02-26 Biotrove, Inc. Microfluidic transfer pin
US20040037748A1 (en) * 2002-08-23 2004-02-26 Leila Hasan Voltage-aided transfer pins
US8685340B2 (en) 2002-08-23 2014-04-01 Life Technologies Corporation Microfluidic transfer pin
JP2005536727A (ja) * 2002-08-23 2005-12-02 バイオトローブ・インク 毛管作用移送ピン
US8697452B2 (en) 2002-12-20 2014-04-15 Life Technologies Corporation Thermal cycling assay apparatus and method
US7682565B2 (en) 2002-12-20 2010-03-23 Biotrove, Inc. Assay apparatus and method using microfluidic arrays
US9428800B2 (en) 2002-12-20 2016-08-30 Life Technologies Corporation Thermal cycling apparatus and method
US20060094108A1 (en) * 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
US20070003448A1 (en) * 2004-03-12 2007-01-04 Kanigan Tanya S Nanoliter array loading
US9266108B2 (en) 2004-03-12 2016-02-23 Life Technologies Corporation Nanoliter array loading
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DE1598080A1 (de) 1970-04-02
FR1457933A (fr) 1966-11-04
NL6515933A (enrdf_load_stackoverflow) 1966-06-13
US3363468A (en) 1968-01-16
GB234220A (en) 1925-05-28
DE1598080B2 (de) 1971-08-12
CH448571A (de) 1967-12-15
SE313938B (enrdf_load_stackoverflow) 1969-08-25
GB1121659A (en) 1968-07-31

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