US3183907A - Device for inhalation aerosol - Google Patents

Device for inhalation aerosol Download PDF

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Publication number
US3183907A
US3183907A US204913A US20491362A US3183907A US 3183907 A US3183907 A US 3183907A US 204913 A US204913 A US 204913A US 20491362 A US20491362 A US 20491362A US 3183907 A US3183907 A US 3183907A
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US
United States
Prior art keywords
aerosol
closed chamber
tube
aerosol container
discharge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US204913A
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English (en)
Inventor
Bush Vannevar
John A Hastings
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to US204913A priority Critical patent/US3183907A/en
Priority to GB22382/63A priority patent/GB1021739A/en
Priority to SE7009/63A priority patent/SE305719B/xx
Priority to FR939332A priority patent/FR1361139A/fr
Application granted granted Critical
Publication of US3183907A publication Critical patent/US3183907A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0091—Inhalators mechanically breath-triggered
    • A61M15/0096—Hindering inhalation before activation of the dispenser

Definitions

  • This invention relates to a device for use in inhalation therapy with aerosols. More particularly, the invention relates to a simple, inexpensive device to be attached to an aerosol container of medication which, upon proper actuation, provides exceptionally deep penetration of the medication into the lung cavities.
  • FIGURE 1 is a view, in perspective, of the inhalation device and attached aerosol container and showing the manner of their use;
  • FIGURE 2 is a vertical elevation of the inhalation device alone, looking into the mouth end of the inhalation tube; 7
  • FIGURE 3 is an exploded side elevation view of the inhalation device and attached aerosol container
  • FIGURE 4 is a vertical sectional view of the inhalation device taken along the line4*4 of FIGURE 2, showing also the aerosol container in position at the top of the device;
  • FIGURE 5 is a view similar to FIGURE 4 showing the positions of the parts when the actuating thumb button is pushed upwardly;
  • FIGURE 6 is a transverse sectional view of the lower part of the inhalation device taken along the line 66 of FIGURE 4. 7
  • the inhalation device generally designated 10 has attached thereto an aerosol container generally designated 11.
  • the aerosol container 11 When the device is in position for use, as shown, the aerosol container 11 is in inverted position and closely fitted within the upper portion 12 of the vertical tube 13 of the device 10.
  • the horizontal tube 14 of the device 10 serves as the gas expansion chamber and mouthpiece.
  • the device When using the device, it is grasped in the hand and positioned so that the open end of the horizontal tube 14 is grasped firmly by the mouth, with the tube 13 positioned vertically and the thumb under the thumb button 16.
  • the index finger is placed over the top of the aerosol container, which, since the container is in inverted position, is the base of the container.
  • the first and third fingers are conveniently on opposite sides of the vertical tube 13.
  • the inhalation deviceltl consists of three main parts. These are (1) the T-shaped chamber, generally designated 17, formed by the horizontal tube 14 and the vertical tube 13 intersecting therewith so that part of the vertical tube 13 Patented May 18, 1965 is above the horizontal tube 14 and part is below the horizontal tube 14; (2) the main stem generally designated 18; and (3) the thumb button 16 and its associated parts.
  • the interior of the upper portion 12 of vertical tube 13 fits closely around the circular perimeter of the metal closure and sealing cap 20 of the aerosol container 11.
  • the tip end 21 of the upper tube portion 12 engages the outer surface of the neck 22 of the aerosol container 11.
  • the hollow discharge valve stem 23 of the aerosol container Projecting downwardly through the center of the closure and sealing cap 20 of the aerosol container 11 is the hollow discharge valve stem 23 of the aerosol container.
  • the valve of the container is actuated to cause a discharge of propellant and active ingredient downwardly out of the hollow valve stem 23.
  • the detailed construction of the aerosol valve is not part of this invention, and so is not shown.
  • the aerosol valve is of the type known as a metering valve, by means of which a measured quantity of the propellant and active ingredient mixture in the aerosol container is discharged to form a single burst of aerosol mist. To effect discharge of more of this mixture, the aerosol valve stem must be returned to its normal position and then reactuated to the discharge posit-ion.
  • Thumb button 16 projecting below the lower portion 15 of tube 13 is the part of the inhalation device that is manually operated by the user of the device to actuate the aerosol valve stem 23.
  • Thumb button 16 has a cylindrical piece 24 extending upwardly therefrom. The upper end of this piece 24 is hollow so as to fit tightly about the lowerrcylindrical portion 25 of the main stem 18.
  • This main stem 18 also includes, in the following order from bottom to top, a flange portion 26, a solid portion 27, a hollow portion 28, and a valve stem receiving portion 29.
  • This last portion 29 of main stem 18 has a cylindrical recess 30 therein, the annular wall of which fits closely, but not tightly, about the lower end of the aerosol discharge valve stem 23, with the base of the recess 30 abutting the end of the stem 23.
  • the upper end of recess 30 may be tapered outwardly, as at'31, so asto guide the aerosol valve stem 23 into the recess 30 when the aerosol container 11 is operatively assembled with the inhalation device 16.
  • this vertical passageway 33 connects with a horizontal passageway 34 that is quite small and that extends radially out- .wardly in the direction of the mouth of horizontal tube 14.
  • This passageway 34 serves as an orifice, and for better control of the orifice characteristics, the length of the passageway 34 is reduced by substantially enlarging the diameter of the passageway nearest the surface of hollow portion 28 of main stem 18, as indicated at 35.
  • thumb button 16 when thumb button 16 is pushed, upwardly (as shown in FIGURE 5), the main stem 18 is moved upwardly, and with ,it the aerosol valve stem 23 is moved upwardly, to effect a discharge of the measured quantity of propellant and active ingredient mixture in the aerosol container.
  • This mixture is discharged down the vertical passageway 33 and out through the orifice, formed by horizontal passageway 34, into the horizontal tube 14, as indicated at 36.
  • the bottom end of the lower portion of the vertical tube 13 is partially closed by an inwardly projecting wall forming an annular wall having a circular opening 41 therein.
  • the upwardly extending cylindrical portion 24 of thumb button 16 passes through this opening 41, with an appreciable radial clearance therebetween.
  • the lower portion of vertical tube 13 has three inwardly projecting ridges 42 formed on the inside of the tube. These ridges 42 extend axially upward from the Wall to about the lowest point of intersection of the horizontal tube 14 with the vertical tube 13.
  • the diameter of flange portion 26 of main stem 18 is somewhat less than the inside diameter of the lower portion 15 of vertical tube 13, thereby providing a clearance 43 between the periphery of the flange portion 26 and the inside of the lower portion 15 of vertical tube 13.
  • the diameter of flange portion 26 is larger than the diameter of the circle tangent to the inner faces 44 of the ridges 42 at the bottom of tube 13 (i.e., at annular wall 40).
  • Flange portion 26 is provided with three slots in its periphery which fit about the respective ridges 42 and permit the flange portion 26 to be moved downwardly until its bottom surface 46 is in engagement with the inner surface of annular wall 40.
  • the main stem 18 is always oriented so that its orifice 34 discharges the aerosol mixture parallel to the axis of horizontal tube 14- and in the direction of the open end of horizontal tube 14.
  • the flange 26 acts to seal the lower portion 15 of vertical tube 13 against the passage of air into the tube 13 from outside the tube while the aerosol container 11 and its metering valve are in normal, unactuated position, as shown in FIGURE 4.
  • the air mixes with the propellant and medication to form an aerosol mist in the horizontal tube 14.
  • This mist is carried deep into the breathing apparatus and lungs of the user by virtue of the relatively significant initial sub normal pressure, or vacuum, created in the breathing apparatus and lungs just prior to the actuation of the thumb button 16, and the sudden release of that vacuum when the thumb button 16 is actuated to produce the formation of the aerosol mist in the horizontal tube of the device.
  • the inhalation device described is a simple and inexpensive device that enables the medication within the aerosol container to be administered very deep in the lung cavities. This depth of administration is greater than can be effected by presently known or available small-size, pocket-type, manually-actuated aerosol inhalation devices.
  • An aerosol inhalation device for administering to the lung cavities a medication stored with a propellant under pressure in an aerosol container having a hollow discharge valve stem projecting from a sealing closure, said device comprising: (a) a closed chamber effected by having an inlet opening adapted to fit in a substantially air-tight manner about the sealing closure of the aerosol container with the aerosol discharge valve inside the chamber, said closed chamber also having an outlet tube adapted to be grasped by the lips of the user and through which an aerosol mist, when it is formed in the closed chamber, passes into the mouth of the user, said closed chamber also having vent means, which, when actuated to open position, admits air from the exterior of said closed chamber to the interior of said closed chamber; (b) mechanism positioned within said closed chamber adapted to engage said aerosol discharge valve stem and, when displaced, moving said aerosol valve stem to discharge a propellant-medication mixture from the aerosol container into said closed chamber and in the direction of the outlet tube; (c) an aerosol actuating button positioned outside
  • said connecting means (d) includes a rod that is secured at one end to said actuating button (0) and that is secured at the other end to said aerosol valve moving mechanism (b), with said vent means including said rod extending through an aperture in said closed chamber (a) that is substantially larger than the exterior of said rod, so that air can pass into said chamber through said aperture, said rod having a washer-like flange portion positioned thereon just inside the closed chamber and engaging the inner wall thereof in the vicinity of the aperture through which the rod passes into the closed chamber and serving to close cit such aperture when a the aerosol actuating button (0) and the aerosol valve moving mechanism (27) are in non-actuated position, but with said washer-like flange portion moved away from engagement with the inner wall or" said closed chamber, and thereby automatically opening said aperture through which said rod passes to enable the passage of air into said closed chamber, when the user moves the aerosol actuating button (c) into aerosol-actuated position.
  • the connecting means is a substantially vertical rod having a cylindrical recess at the top into which the lower end of the aerosol discharge valve stem fits, said rod having a passageway smaller in diameter than the base of said cylindrical recess and extending from said base downwardly to just below the axis of the horizontal tube, said rod also having an aperture from said passageway at right angles to the axis of the rod and serving as an orifice for the discharge of the propellant and medication mixture from the aerosol container into the area where the horizontal tube intersects the vertical tube, with the orifice directed to discharge such mixture toward the end of the horizontal tube in the users mouth, the bottom end of said rod being attached to the upwardly extending member of the actuating button and having afiixed thereto, just inside the lower end of the vertical tube, the flange that overlays the opening in the annular wall and normally is in engagement with the interior surface of the annular wall.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
US204913A 1962-06-25 1962-06-25 Device for inhalation aerosol Expired - Lifetime US3183907A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US204913A US3183907A (en) 1962-06-25 1962-06-25 Device for inhalation aerosol
GB22382/63A GB1021739A (en) 1962-06-25 1963-06-05 Inhaler
SE7009/63A SE305719B (xx) 1962-06-25 1963-06-25
FR939332A FR1361139A (fr) 1962-06-25 1963-06-25 Dispositif pour l'inhalation d'aérosols

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US204913A US3183907A (en) 1962-06-25 1962-06-25 Device for inhalation aerosol

Publications (1)

Publication Number Publication Date
US3183907A true US3183907A (en) 1965-05-18

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Family Applications (1)

Application Number Title Priority Date Filing Date
US204913A Expired - Lifetime US3183907A (en) 1962-06-25 1962-06-25 Device for inhalation aerosol

Country Status (3)

Country Link
US (1) US3183907A (xx)
GB (1) GB1021739A (xx)
SE (1) SE305719B (xx)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3404681A (en) * 1962-03-02 1968-10-08 Benger Lab Ltd Aerosol dispenser
DE1566630B1 (de) * 1966-03-31 1971-10-28 Merck & Co Inc Geraet zur Abgabe dosierter Mengen eines medizinischen Wirkstoffs
DE2415360A1 (de) * 1973-06-27 1975-01-23 American Cyanamid Co Aerosolabgabevorrichtung fuer ein pulverfoermiges medikament in gleichfoermigen dosen
US5020527A (en) * 1990-02-20 1991-06-04 Texax-Glynn Corporation Inhaler device with counter/timer means
EP0775499A2 (en) 1995-11-22 1997-05-28 Iep Group, Inc. Counters for fluid dispensers
EP0862921A2 (en) * 1997-03-03 1998-09-09 Bespak plc Improved inhalation apparatus
WO2000044423A1 (en) 1999-02-01 2000-08-03 Iep Pharmaceutical Devices Inc. Metered dose inhaler agitator
US20050158394A1 (en) * 2000-02-28 2005-07-21 Vectura Limited Delivery of oral drugs
US20090050158A1 (en) * 2004-06-07 2009-02-26 Wilem Wassenaar Nasal adaptation of an oral inhaler device

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4396153A (en) * 1981-09-24 1983-08-02 Smrt Thomas John Spray tip for aerosol can
GB2366519B (en) * 2000-09-08 2002-11-20 Bespak Plc Improvements in or relating to dispensing apparatus
GB201308679D0 (en) 2013-05-14 2013-06-26 3M Innovative Properties Co Actuator for an inhaler
GB201322677D0 (en) 2013-12-20 2014-02-05 3M Innovative Properties Co Actuator for an inhaler
GB201401659D0 (en) 2014-01-31 2014-03-19 3M Innovative Properties Co Actuator for an inhaler

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US852828A (en) * 1906-11-26 1907-05-07 Frank C Dorment Atomizer.
US2266704A (en) * 1937-05-19 1941-12-16 Stanley L Fox Nebulizing inhalator for medication
US2890697A (en) * 1957-03-15 1959-06-16 Wilton E Van Sickle Enclosed medicament container and atomizer
GB834137A (en) * 1957-02-18 1960-05-04 Herbert Mcfarlan Birch Means for administering medication orally into the respiratory organs
US2965100A (en) * 1957-11-01 1960-12-20 Sparklets Ltd Applicators
US2985382A (en) * 1958-03-31 1961-05-23 Coplan Rachel Directional cap for spray dispenser
US2992645A (en) * 1958-05-06 1961-07-18 Benger Lab Ltd Disperser for powders
US3006340A (en) * 1958-03-03 1961-10-31 Meshberg Philip Dispensing package
US3012555A (en) * 1959-05-18 1961-12-12 Meshberg Philip Dispensing package for material under pressure

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US852828A (en) * 1906-11-26 1907-05-07 Frank C Dorment Atomizer.
US2266704A (en) * 1937-05-19 1941-12-16 Stanley L Fox Nebulizing inhalator for medication
GB834137A (en) * 1957-02-18 1960-05-04 Herbert Mcfarlan Birch Means for administering medication orally into the respiratory organs
US2890697A (en) * 1957-03-15 1959-06-16 Wilton E Van Sickle Enclosed medicament container and atomizer
US2965100A (en) * 1957-11-01 1960-12-20 Sparklets Ltd Applicators
US3006340A (en) * 1958-03-03 1961-10-31 Meshberg Philip Dispensing package
US2985382A (en) * 1958-03-31 1961-05-23 Coplan Rachel Directional cap for spray dispenser
US2992645A (en) * 1958-05-06 1961-07-18 Benger Lab Ltd Disperser for powders
US3012555A (en) * 1959-05-18 1961-12-12 Meshberg Philip Dispensing package for material under pressure

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3404681A (en) * 1962-03-02 1968-10-08 Benger Lab Ltd Aerosol dispenser
DE1566630B1 (de) * 1966-03-31 1971-10-28 Merck & Co Inc Geraet zur Abgabe dosierter Mengen eines medizinischen Wirkstoffs
DE2415360A1 (de) * 1973-06-27 1975-01-23 American Cyanamid Co Aerosolabgabevorrichtung fuer ein pulverfoermiges medikament in gleichfoermigen dosen
US5020527A (en) * 1990-02-20 1991-06-04 Texax-Glynn Corporation Inhaler device with counter/timer means
EP0775499A2 (en) 1995-11-22 1997-05-28 Iep Group, Inc. Counters for fluid dispensers
EP0862921A2 (en) * 1997-03-03 1998-09-09 Bespak plc Improved inhalation apparatus
EP0862921A3 (en) * 1997-03-03 1998-11-25 Bespak plc Improved inhalation apparatus
WO2000044423A1 (en) 1999-02-01 2000-08-03 Iep Pharmaceutical Devices Inc. Metered dose inhaler agitator
US6116234A (en) * 1999-02-01 2000-09-12 Iep Pharmaceutical Devices Inc. Metered dose inhaler agitator
US20050158394A1 (en) * 2000-02-28 2005-07-21 Vectura Limited Delivery of oral drugs
EP1941868A2 (en) 2000-02-28 2008-07-09 PharmaKodex Limited Improvements in or relating to the delivery of oral drugs
US20090050158A1 (en) * 2004-06-07 2009-02-26 Wilem Wassenaar Nasal adaptation of an oral inhaler device

Also Published As

Publication number Publication date
SE305719B (xx) 1968-11-04
GB1021739A (en) 1966-03-09

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