US2895474A - Aspirating cartridge syringe - Google Patents
Aspirating cartridge syringe Download PDFInfo
- Publication number
- US2895474A US2895474A US479818A US47981855A US2895474A US 2895474 A US2895474 A US 2895474A US 479818 A US479818 A US 479818A US 47981855 A US47981855 A US 47981855A US 2895474 A US2895474 A US 2895474A
- Authority
- US
- United States
- Prior art keywords
- cartridge
- piston rod
- sleeve
- syringe
- tip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000003811 finger Anatomy 0.000 description 42
- 239000003708 ampul Substances 0.000 description 19
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- 239000007799 cork Substances 0.000 description 5
- 238000010276 construction Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 210000003462 vein Anatomy 0.000 description 3
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2403—Ampoule inserted into the ampoule holder
- A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2403—Ampoule inserted into the ampoule holder
- A61M2005/2414—Ampoule inserted into the ampoule holder from the side
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2485—Ampoule holder connected to rest of syringe
- A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2485—Ampoule holder connected to rest of syringe
- A61M2005/2496—Ampoule holder connected to rest of syringe via pivot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M5/31515—Connection of piston with piston rod
Definitions
- 'Ihisinventiom relates to the typeof cartridge syringe which 'utilizesadisposable ampoule or cartridge containingi thermaterial to be injected, and this invention is also directed to the ampoule or cartridge itself.
- A- principal object of .the invention resides: in the provision of a syringe usable for injection as conventional with zpriorart types'of cartridges or ampoules, but which also is provided with means. to grip the cartridge plunger to move the. latter in. either direction relative to the cartridge, for aspiration as well. as injection; and the provisionofaa novel cartridge or ampoule including a plunger having means by which it may be gripped by the piston rod of the novel syringe, said novel cartridge being also usableyin the. usualmanner with prior art syringes.
- Another object of this invention resides in the provisiontof a syringe using a disposable cartridge having a cork:..or plunger made wholly of rubber or like material and. having .anextending. tip, and including inter-engaging. means between the piston rod for the syringe and the tip of the rubber plunger of the ampoule or cartridge, whereby the latter may be positively engaged and retracted by the piston rod for aspiration prior to injection, asv well. as moved in a direction to cause injection;
- FIG. 1 is a view in side elevation of a device according to the present invention, parts being in section;
- Fig. 2 is an enlarged section on line 2-2 of Fig. 1;
- Figs. 3 and 4 are sections on respective lines 3-3 and 44 in Fig. 2;
- Fig. 5 is a view similar to Fig. 2 but showing the syringe piston disengaged from the plunger of the cartridge and a modified actuating structure;
- Fig.- 6 is a section on line 6.6 of Fig. 5;
- Fig. 7 he side elevation of'a difierent type of syringe using the invention.
- Fig. 8 is an enlarged section on line 8-8 of Fig. 7;
- Fig. 9 is a longitudinal section through a difierent type ofsyringe
- Fig. 10 is an enlarged section showing a modification, parts being broken away;
- Fig. 11 is a section on line 1'111 of Fig. 10;
- Fig. 12 is a view in elevation, looking in the direction of arrow 12 in Fig. 10, parts being in section;
- Figs. 13 and 14 are sectionsshowing stillfurther modifications.
- Fig. l5- is a section on line 1'5-15of Fig. '14.
- One syringe used as illustrative of the present invention includes a barrel 10 whichmay be provided with one or more observation windows or openings 12; a hypodermic needle 14 for conducting the contents of a dis posable ampoule or cartridge 16 in the barrel 10 through a cartridge-end piercing inner needle 18 located in the tip of the barrel as shown in Fig.- l; and a piston rod 20 for exerting pressure uponthe plunger 22 of the cartridge to expel the contents thereof through the needle.
- the cartridge 16 being providedwith the plunger or cork 22, normally is engaged by the inner end of the piston rod 20 to exert pressure thereon to move the same along in the cartridge to expelthe contents of the cartridge as stated; In the prior art, however, there can be no aspirating by means of theneedle 14, and the only possibleaction is to press the piston rod 20 for instance to theright in Figs. 1 and 2.
- the cartridge plunger cannot be withdrawn or moved to the left. Of course when the cartridge has been used, it is thrown away and another cartridge is placed in the syringe.
- cartridge and ampoule are used interchangeably in this case.
- Loosening of the rotary locking sleeve 24 as in Figs. 1 and 2 in a manner well known in the art to allow pivoting of the hinged head 26, provides for opening the breech endof the barrel 10 for the extractionof a spent cartridge and insertion of a new cartridge without interference from the piston rod 20 orthe hinged head 26.
- the head 26 may be'provided with the usual fingerhold 28.
- the invention provides an integrally molded, distortable rubber-like tip on the cartridge plunger 22, as clearly shown at 30 in Fig. 2, this rubber tip extending or at least facing to the exterior of the cartridge 16.
- Any rubbery material may be used for the plunger and its tip, and the tip may be plain and smooth as in Fig. 5, or serrated or toothed as indicated in Fig. 2.
- a gripping member generally indicated at 32 in Fig. 2, attached to the piston rod 20 or the like at the inner end thereof as respects the barrel 19.
- Member 32 is provided with resilient gripping fingers 34 which may be provided with serrations 36 at the interior thereof, the fingers being arranged generally radially (see Fig. 3) and designed to be radially compressed to be brought toward each other to firmlygrip the-rubber tip.
- the means provided for causing the gripping fingers to move radially toward each other to grip the rubber tip may take the form of an exterior barrel or sleeve indicated at 38.
- This barrel may be rotatable relative to the gripping fingers and member 32, and if desired, may be provided with inter-engaging threads 40 for providing, relative longitudinal motion between gripping fingers 34 and the actuating sleeve 38 in order to cause the fingers 34 to move inwardly relative to each other.
- the exterior surfaces of the gripping fingers extend radially outwardly past the internal diameter of sleeve '38 innormal extended condition, and thesleeve 38 acts 3 in the nature of a cam to compress the fingers upon the required relative axial motion thereof.
- the sleeve 38 may be extended as at 42 and may be knurled at this end as at 44 and it may extend outwardly of the knurled locking sleeve 24 for convenience in operation (see Fig. 1).
- the head 26 is replaced in its operative position axially aligned with barrel 10.
- the locking sleeve 24 is then turned up to lock the parts in position in the usual manner.
- the knurled end 44 of sleeve 42 may then be turned relative to piston rod 20, either the rod or sleeve being held by one hand while the other member is rotated by the fingers of the other hand, so that with the inner end of the piston rod adjacent the plunger 22, gripping fingers 34 will move radially inwardly and firmly grip the rubber tip 30, so that the plunger 22 and piston rod 20 will move together in either direction.
- the act of aspiration then becomes simple and clearly apparent to those skilled in the art, since merely by withdrawing slightly on piston rod 20, as for instance by means of the thumbpiece 46 thereon, blood from any vein pierced by needle 14 will be withdrawn and the piercing of the vein will then be apparent to the operator.
- FIG. A modification is shown in Fig. wherein the gripping fingers are illustrated as retracted, and the cartridge plunger 22 is free.
- the gripping finger actuator barrel 42 instead of being rotatable within the locking sleeve 24, is axially slidably keyed thereto as by slot 48 and key 50, so that the locking sleeve 24 upon being rotated to lock the cartridge in position also rotates the gripper finger actuating sleeve 42 relative to the piston rod 26, thus accomplishing two actions, that of locking the head 26 as usual, and also of causing gripper fingers 34 to be moved radially inwardly to firmly engage and grip the rubber tip 30.
- the key may be provided with a tight fit interiorly of the locking sleeve 24 and with a loose fit with reference to keyway 48 to provide for axial sliding of the sleeve 42 relative to locking sleeve 24, so that the sleeve 42 and piston rod 20 may be slid inwardly from the Fig. 5 position to the position of Fig. 2, to contact the tip 30, and in the construction shown in Fig. 5, this operation is done prior to actually locking the head 26 in position by means of the locking sleeve 24.
- the syringe piston rod 20 and sleeve actuator 42 may be independently slid axially to engage or release the plunger 22.
- the sleeve 42 is held against rotation by the seated sleeve 24, and merely by digitally rotating the piston 20, the fingers 34 will be actuated to grip or release tip 30.
- the piston rod and cartridge tip gripping device may be made for replacement of the usual piston in the conventional syringe of the class described.
- the usual piston With the locking sleeve released and slightly pivoted to make a small angle with the barrel of the syringe, the usual piston is removable by axially sliding it inwardly through a barrel window, after removing the thumbpiece 46 which is threaded in the piston. The new piston is then applied in a reverse manner.
- a more or less conventional type of syringe which is different from that shown in Fig. l in that the piston rod 52, operated by a handle 54, does not pivot in any way with respect to the cartridge-receiving barrel 56.
- This barrel is open at least at one side thereof as indicated at 58 and receives the disposable cartridge or ampoule through this opening.
- This type of syringe is commonly referred to as a side loader.
- the barrel 56 has fixed thereto a pair of annular members 60 which axially constrain a rotary ring 61 provided with fingerholds 64.
- the rings 60 may be mounted on a ferrule or the like 66 which is 4 internally threaded at 68 to receive the locking member 70 externally threaded as shown and having a thumb piece or the like in annular form at 72 for locking the disposable cartridge, as for instance that indicated at 74, in position in the barrel 56.
- the locking member 70 may be adjustably secured in position by well known means and need not be removed in any way, see particularly Fig. 8.
- the syringe piston rod 52 may have a threaded en gagement at 76 with respect to the operating sleeve 78 which corresponds in general to that at 42 in Fig. 2.
- This assembly is slidable within the locking member 70 and the piston rod 52 terminates in a series of -compressible fingers 80 which are comparable to those at 34.
- the operating sleeve 78 is provided with the collet member 82, and upon rotation of piston rod 52 relative to operating sleeve 78, fingers 80 will be moved inwardly to grasp the rubber tip 84, which in this case may be the same as that at 30 in Fig. 2.
- Tip 84 is of course made as a portion of the plunger 86 of the disposable cartridge 74.
- the locking member is backed off to release the used ampoule or cartridge which is then disposed of through the window 58, whereupon a new cartridge or ampoule is disposed in the barrel 56 and the locking member 70 is then turned up to engage and lock the ampoule or cartridge in the position of Fig. 8.
- the assembly of the syringe piston rod 52 and operating sleeve 78 is then slid inwardly, i.e. to the right in Fig. 8, until the rubber tip 84 is included between the fingers 80, whereupon relative rotation of the piston rod 52 relative to the sleeve 78 causes the fingers 80 to grip the tip 42 as previously described.
- the syringe of Fig. 7 is provided with the needle tip assembly 88 as is customary.
- Fig. 9 illustrates the use of the device with still a further type of syringe, wherein a barrel 90, which may be of clear glass or plastic tubing, is provided with a screw cap 92 completely removable therefrom to allow the insertion of the replaceable cartridge or ampoule 94, the same having a rubber cork or plunger 96 with a tip, as before described. Also, the barrel is provided with a needle assembly 98 as is customary, and the syringe piston rod 100 is provided in assembled relation with respect to the removable cap 92 which is preferably made of plastic or the like. There is also present an operating sleeve 102 which is comparable to that at 78 and gripping fingers 104 may be utilized in a manner similar to that in Figs. 2 and 8.
- threads 76 and 106 are interchangeable as mechanical expedients, it only being necessary to provide a positive sliding action be tween the syringe piston rod and its operating sleeve in order to compress the gripping fingers as described to grip the rubber tip and to thereupon carry out the aspiration and injection as desired.
- FIG. 10 A modified type of device is shown in Figs. 10, l1 and 12 wherein the reference numeral 108 indicates a barrel receiving the ampoule or cartridge 110 having the plunger 112 with the rubber tip 114.
- This barrel 108 is operatively connected to a head or the like generally shown and indicated at 116, this head being comparable mechanically to that at 66 in Fig; 8 or 26 in Fig. 2, and
- the syringe piston rod is indicated at 120 and it is surrounded at least in part by the operating sleeve 122 which extends forwardly in the collet member 124 which will cause the finger members 126 to move radially inwardly to grip the tip 114 when aligned with the same as will be apparent from the discussion above.
- the locking member 118 is provided with a radially serrated forwardly-extending shoulder indicated at 128 and having clutching engagement with a similar serrated rearwardly facing shoulder 130 which is on the sleeve 122 inwardly of the collet member 124.
- the members meet so that when the locking sleeve 118 is almost but not quite in its inwardmost locking position, fingers 126 will substantially embrace the tip 114.
- Rotation of sleeve 118 will then cause rotation of operating sleeve 122 relative to piston rod 120 and the threads on the collet member 124 and fingers 126 will engage to cause a relative axial motion, clamping the fingers 126 on to the tip 114, so that rotation of the locking sleeve to locking position of the cartridge, also will cause the piston rod to grip the tip of the plunger of the disposable cartridge.
- Fig. 13 shows a still further modification wherein the disposable cartridge is indicated at 130 and the barrel in which it is located is indicated at 132.
- the barrel head is 134 and the locking sleeve is indicated at 136.
- the piston rod 138 of the syringe has an operating sleeve 141%.
- the locking head 136 is provided with the shoulder 142 and the inward end of the operating sleeve 140 is provided with an opposite complementary shoulder 144, so that when the locking sleeve 136 is moved to the right in Fig. 13, it will also move the operating sleeve 148, and this action causes the collet member 146 to slide on the smooth outer surfaces of fingers 148 and thus compress the same to clamp the rubber tip 150.
- detents at 152 and corresponding projections at 154 may also be provided detents at 152 and corresponding projections at 154 in order to lightly secure the operating sleeve 140 to the piston rod 138 in order to provide for the temporary and light securement of these parts together in order to accomplish the aspirating function, but it is clear that a deliberate pull on piston rod 138 will release the detent and allow the retraction of the fingers to release the tip 150.
- Figs. 14 and 15 illustrate a still further form of the invention but in this case the difference between the construction of Fig. 14 and the construction of Figs. 5 or resides in a circumferential series of parallel axially arranged corresponding serrations 156, so that the locking sleeve 158, which may be the same as that at 136 otherwise, will rotate the operating sleeve 160 relative to syringe piston rod 162 as the locking sleeve is rotated to bring it into locking engagement with the disposable cartridge or ampoule. Otherwise the construc tion and operation of the parts is the same as before but it will be appreciated that in all of the cases of Figs.
- the piston rod for the syringe and the operating sleeve for the gripping fingers are capable of relative axial motion, but are relatively non-rotational when it is desired to lock the cartridge in place and to engage the gripping fingers with the rubber tip of the cartridge plunger.
- a syringe for use with a disposable ampoule cartridge having a plunger and said plunger having an exposed tip extending therefrom, said syringe comprising a barrel for receiving the cartridge, a needle and a piston rod associated with the barrel, and means on said piston rod for gripping the cartridge plunger tip for movement of the cartridge plunger with the piston rod in either direction for both aspiration and injection, the plunger tip gripping means comprising radially movable gripping fingers on the piston rod at the inner end there of and including means for moving said fingers radially inwardly to grip the tip, said fingers being resilient and normally retracted, the means for actuating the gripping fingers comprising a locking sleeve, a second sleeve ro tatable on the piston rod and non-rotatably associated with the locking sleeve for rotation by the locking sleeve, and inter-engaging means between said second sleeve and the gripping fingers moving said fingers radially inwardly upon relative axial motion
- a syringe for use with a disposable ampoule cartridge having a plunger and said plunger having an exposed tip extending therefrom, said syringe comprising a barrel for receiving the cartridge, a needle and a piston rod associated with the barrel, and means on said piston rod for gripping the cartridge plunger tip for movement of the cartridge plunger with the piston rod in either direction for both aspiration and injection, the plunger tip gripping means comprising radially movable gripping fingers on the piston rod at the inner end thereof and including means for moving said fingers radially inwardly to grip the tip, said fingers being resilient and normally retracted, the means for actuating the gripping fingers comprising a locking sleeve, a.
- second sleeve rotatable on the piston rod and associated with the locking sleeve for rotation by the locking sleeve, inter-engaging means between said second sleeve and the gripping fingers moving said fingers radially inwardly upon relative axial motion thereof, and means to selectively engage or disengage the two sleeves for unirotational motion or separate, relative rotation with respect to each other.
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
July 21, 1959 s. REZNEK 2,
ASPIRATING CARTRIDGE SYRINGE File'd Jan. 4, 1955 z She ets-Sheet 1 INVENTOR SOLOMON REZNEK 1959 s. REZNEK 2,895,474
ASPIRATING CARTRIDGE SYRINGE Filed Jan. 4, 1955 3 Sheets-Sheet 2 v EENJQQ INVENTOR SOLOMON REZNEK ATTORNEY July 21, 1959 I s. REZNEK ASPIRATING CARTRIDGE SYRINGE 3 Sheets-Sheet 3 Filed Jan. 4, 1955 INVENTOR SOLOMON REZNEK ATTORNEY United States Patent... 6
2,895,474 ASPIRATING CARTRIDGE SYRINGE Solomon". Reznek, A'lbany,*N.Y., assignor to Cook-Waite Laboratories,alnc. ,.New York,.N.Y., a corporation of Delaware Application'January 4; 1955, Serial No. 479,818 aclaims. (onus-21s);
'Ihisinventiom relates to the typeof cartridge syringe which 'utilizesadisposable ampoule or cartridge containingi thermaterial to be injected, and this invention is also directed to the ampoule or cartridge itself. Thepresent invention is directed to novel structure of thesyringe and also'to1.the= syringe in cooperative combination with a novel plunger or cork for the ampoule or cartridge for providing a connectionbetween the cartridge plunger and-the pistonrod of the syringe to provide'for an aspiratinggeifect as well as injection.
Ithasbeenfoundthat inmany cases the use of this type .of syringe, that the: operator may puncture a vein, and the consequent injection of the local anesthetic is at least partially intravenous, resulting in undesirable side reactions and loss of anesthetic efiiciency, so that aspirationpisiofconsiderable importance to locate a desired spot prior to injection.
A- principal object of .the invention resides: in the provision of a syringe usable for injection as conventional with zpriorart types'of cartridges or ampoules, but which also is provided with means. to grip the cartridge plunger to move the. latter in. either direction relative to the cartridge, for aspiration as well. as injection; and the provisionofaa novel cartridge or ampoule including a plunger having means by which it may be gripped by the piston rod of the novel syringe, said novel cartridge being also usableyin the. usualmanner with prior art syringes.
Another object of this invention resides in the provisiontof a syringe using a disposable cartridge having a cork:..or plunger made wholly of rubber or like material and. having .anextending. tip, and including inter-engaging. means between the piston rod for the syringe and the tip of the rubber plunger of the ampoule or cartridge, whereby the latter may be positively engaged and retracted by the piston rod for aspiration prior to injection, asv well. as moved in a direction to cause injection;
Further objects of the invention include the provision of a new and improved ampoule or cartridge which is very .easily disengagedfrom the springe piston rod when the injection is finished; and in addition, the invention provides against the staining by corrosion of the .usual metal inserts of prior art aspirating cartridges, etc. during storage.
Other objects and advantages of the invention will appear hereinafter.
Reference is to be had to the accompanying drawings, in which Fig. 1 is a view in side elevation of a device according to the present invention, parts being in section;
Fig. 2 is an enlarged section on line 2-2 of Fig. 1;
Figs. 3 and 4 are sections on respective lines 3-3 and 44 in Fig. 2;
Fig. 5 is a view similar to Fig. 2 but showing the syringe piston disengaged from the plunger of the cartridge and a modified actuating structure;
Fig.- 6 is a section on line 6.6 of Fig. 5;
Fig. 7 he side elevation of'a difierent type of syringe using the invention;
Fig. 8 is an enlarged section on line 8-8 of Fig. 7;
Fig. 9 is a longitudinal section through a difierent type ofsyringe;
Fig. 10 is an enlarged section showing a modification, parts being broken away;
Fig. 11 is a section on line 1'111 of Fig. 10;
Fig. 12 is a view in elevation, looking in the direction of arrow 12 in Fig. 10, parts being in section;
Figs. 13 and 14 are sectionsshowing stillfurther modifications; and
Fig. l5-is a section on line 1'5-15of Fig. '14.
One syringe used as illustrative of the present invention: includes a barrel 10 whichmay be provided with one or more observation windows or openings 12; a hypodermic needle 14 for conducting the contents of a dis posable ampoule or cartridge 16 in the barrel 10 through a cartridge-end piercing inner needle 18 located in the tip of the barrel as shown in Fig.- l; and a piston rod 20 for exerting pressure uponthe plunger 22 of the cartridge to expel the contents thereof through the needle.
The cartridge 16 being providedwith the plunger or cork 22, normally is engaged by the inner end of the piston rod 20 to exert pressure thereon to move the same along in the cartridge to expelthe contents of the cartridge as stated; In the prior art, however, there can be no aspirating by means of theneedle 14, and the only possibleaction is to press the piston rod 20 for instance to theright in Figs. 1 and 2. The cartridge plunger cannot be withdrawn or moved to the left. Of course when the cartridge has been used, it is thrown away and another cartridge is placed in the syringe. The terms cartridge and ampoule are used interchangeably in this case.
Loosening of the rotary locking sleeve 24 as in Figs. 1 and 2 in a manner well known in the art to allow pivoting of the hinged head 26, provides for opening the breech endof the barrel 10 for the extractionof a spent cartridge and insertion of a new cartridge without interference from the piston rod 20 orthe hinged head 26. The head 26 may be'provided with the usual fingerhold 28.
In the present case, the invention provides an integrally molded, distortable rubber-like tip on the cartridge plunger 22, as clearly shown at 30 in Fig. 2, this rubber tip extending or at least facing to the exterior of the cartridge 16. Any rubbery material may be used for the plunger and its tip, and the tip may be plain and smooth as in Fig. 5, or serrated or toothed as indicated in Fig. 2.
In addition, for cooperation with this rubber tip 30 there is provided a gripping member generally indicated at 32 in Fig. 2, attached to the piston rod 20 or the like at the inner end thereof as respects the barrel 19. Member 32 is provided with resilient gripping fingers 34 which may be provided with serrations 36 at the interior thereof, the fingers being arranged generally radially (see Fig. 3) and designed to be radially compressed to be brought toward each other to firmlygrip the-rubber tip The means provided for causing the gripping fingers to move radially toward each other to grip the rubber tip may take the form of an exterior barrel or sleeve indicated at 38. This barrel may be rotatable relative to the gripping fingers and member 32, and if desired, may be provided with inter-engaging threads 40 for providing, relative longitudinal motion between gripping fingers 34 and the actuating sleeve 38 in order to cause the fingers 34 to move inwardly relative to each other. The exterior surfaces of the gripping fingers extend radially outwardly past the internal diameter of sleeve '38 innormal extended condition, and thesleeve 38 acts 3 in the nature of a cam to compress the fingers upon the required relative axial motion thereof.
The sleeve 38 may be extended as at 42 and may be knurled at this end as at 44 and it may extend outwardly of the knurled locking sleeve 24 for convenience in operation (see Fig. 1).
After inserting the certridge 16 in the barrel in the usual manner, the head 26 is replaced in its operative position axially aligned with barrel 10. The locking sleeve 24 is then turned up to lock the parts in position in the usual manner.
The knurled end 44 of sleeve 42 may then be turned relative to piston rod 20, either the rod or sleeve being held by one hand while the other member is rotated by the fingers of the other hand, so that with the inner end of the piston rod adjacent the plunger 22, gripping fingers 34 will move radially inwardly and firmly grip the rubber tip 30, so that the plunger 22 and piston rod 20 will move together in either direction. The act of aspiration then becomes simple and clearly apparent to those skilled in the art, since merely by withdrawing slightly on piston rod 20, as for instance by means of the thumbpiece 46 thereon, blood from any vein pierced by needle 14 will be withdrawn and the piercing of the vein will then be apparent to the operator.
A modification is shown in Fig. wherein the gripping fingers are illustrated as retracted, and the cartridge plunger 22 is free. The gripping finger actuator barrel 42 instead of being rotatable within the locking sleeve 24, is axially slidably keyed thereto as by slot 48 and key 50, so that the locking sleeve 24 upon being rotated to lock the cartridge in position also rotates the gripper finger actuating sleeve 42 relative to the piston rod 26, thus accomplishing two actions, that of locking the head 26 as usual, and also of causing gripper fingers 34 to be moved radially inwardly to firmly engage and grip the rubber tip 30.
The key may be provided with a tight fit interiorly of the locking sleeve 24 and with a loose fit with reference to keyway 48 to provide for axial sliding of the sleeve 42 relative to locking sleeve 24, so that the sleeve 42 and piston rod 20 may be slid inwardly from the Fig. 5 position to the position of Fig. 2, to contact the tip 30, and in the construction shown in Fig. 5, this operation is done prior to actually locking the head 26 in position by means of the locking sleeve 24.
It will be seen that if the locking sleeve 24 is fairly Well seated, the syringe piston rod 20 and sleeve actuator 42 may be independently slid axially to engage or release the plunger 22. In this case, the sleeve 42 is held against rotation by the seated sleeve 24, and merely by digitally rotating the piston 20, the fingers 34 will be actuated to grip or release tip 30.
The piston rod and cartridge tip gripping device may be made for replacement of the usual piston in the conventional syringe of the class described. With the locking sleeve released and slightly pivoted to make a small angle with the barrel of the syringe, the usual piston is removable by axially sliding it inwardly through a barrel window, after removing the thumbpiece 46 which is threaded in the piston. The new piston is then applied in a reverse manner.
Referring now to Fig. 7, there is shown a more or less conventional type of syringe which is different from that shown in Fig. l in that the piston rod 52, operated by a handle 54, does not pivot in any way with respect to the cartridge-receiving barrel 56. This barrel is open at least at one side thereof as indicated at 58 and receives the disposable cartridge or ampoule through this opening. This type of syringe is commonly referred to as a side loader.
In this case, the barrel 56 has fixed thereto a pair of annular members 60 which axially constrain a rotary ring 61 provided with fingerholds 64. The rings 60 may be mounted on a ferrule or the like 66 which is 4 internally threaded at 68 to receive the locking member 70 externally threaded as shown and having a thumb piece or the like in annular form at 72 for locking the disposable cartridge, as for instance that indicated at 74, in position in the barrel 56. The locking member 70 may be adjustably secured in position by well known means and need not be removed in any way, see particularly Fig. 8.
The syringe piston rod 52 may have a threaded en gagement at 76 with respect to the operating sleeve 78 which corresponds in general to that at 42 in Fig. 2. This assembly is slidable within the locking member 70 and the piston rod 52 terminates in a series of -compressible fingers 80 which are comparable to those at 34. The operating sleeve 78 is provided with the collet member 82, and upon rotation of piston rod 52 relative to operating sleeve 78, fingers 80 will be moved inwardly to grasp the rubber tip 84, which in this case may be the same as that at 30 in Fig. 2. Tip 84 is of course made as a portion of the plunger 86 of the disposable cartridge 74.
In the operation of this type of syringe, the locking member is backed off to release the used ampoule or cartridge which is then disposed of through the window 58, whereupon a new cartridge or ampoule is disposed in the barrel 56 and the locking member 70 is then turned up to engage and lock the ampoule or cartridge in the position of Fig. 8. The assembly of the syringe piston rod 52 and operating sleeve 78 is then slid inwardly, i.e. to the right in Fig. 8, until the rubber tip 84 is included between the fingers 80, whereupon relative rotation of the piston rod 52 relative to the sleeve 78 causes the fingers 80 to grip the tip 42 as previously described. It is to be understood, of course, that the syringe of Fig. 7 is provided with the needle tip assembly 88 as is customary. V
Fig. 9 illustrates the use of the device with still a further type of syringe, wherein a barrel 90, which may be of clear glass or plastic tubing, is provided with a screw cap 92 completely removable therefrom to allow the insertion of the replaceable cartridge or ampoule 94, the same having a rubber cork or plunger 96 with a tip, as before described. Also, the barrel is provided with a needle assembly 98 as is customary, and the syringe piston rod 100 is provided in assembled relation with respect to the removable cap 92 which is preferably made of plastic or the like. There is also present an operating sleeve 102 which is comparable to that at 78 and gripping fingers 104 may be utilized in a manner similar to that in Figs. 2 and 8.
The operation of this type of syringe will be readily apparent. The cap 92 is completely removed and the spent cartridge or ampoule is taken out of the barrel and thrown away and the new ampoule or cartridge is inserted. The cap 92 is then re-applied and-the piston and sleeve assembly 100 and 102 is slid into place as shown in Fig. 9, whereupon relative rotation of piston rod 100 and sleeve 102 will result in the threads indicated at 166 compressing the fingers (as in Fig. 2) to grip the tip on the cork or cartridge plunger 96.
It is to be understood that the threads 76 and 106 are interchangeable as mechanical expedients, it only being necessary to provide a positive sliding action be tween the syringe piston rod and its operating sleeve in order to compress the gripping fingers as described to grip the rubber tip and to thereupon carry out the aspiration and injection as desired.
A modified type of device is shown in Figs. 10, l1 and 12 wherein the reference numeral 108 indicates a barrel receiving the ampoule or cartridge 110 having the plunger 112 with the rubber tip 114. This barrel 108 is operatively connected to a head or the like generally shown and indicated at 116, this head being comparable mechanically to that at 66 in Fig; 8 or 26 in Fig. 2, and
provides a housing for a part of the locking sleeve which is indicated at 118.
The syringe piston rod is indicated at 120 and it is surrounded at least in part by the operating sleeve 122 which extends forwardly in the collet member 124 which will cause the finger members 126 to move radially inwardly to grip the tip 114 when aligned with the same as will be apparent from the discussion above.
In this case, however, the locking member 118 is provided with a radially serrated forwardly-extending shoulder indicated at 128 and having clutching engagement with a similar serrated rearwardly facing shoulder 130 which is on the sleeve 122 inwardly of the collet member 124.
In this case, the members meet so that when the locking sleeve 118 is almost but not quite in its inwardmost locking position, fingers 126 will substantially embrace the tip 114. Rotation of sleeve 118 will then cause rotation of operating sleeve 122 relative to piston rod 120 and the threads on the collet member 124 and fingers 126 will engage to cause a relative axial motion, clamping the fingers 126 on to the tip 114, so that rotation of the locking sleeve to locking position of the cartridge, also will cause the piston rod to grip the tip of the plunger of the disposable cartridge.
Fig. 13 shows a still further modification wherein the disposable cartridge is indicated at 130 and the barrel in which it is located is indicated at 132. The barrel head is 134 and the locking sleeve is indicated at 136. The piston rod 138 of the syringe has an operating sleeve 141%. In this case, the locking head 136 is provided with the shoulder 142 and the inward end of the operating sleeve 140 is provided with an opposite complementary shoulder 144, so that when the locking sleeve 136 is moved to the right in Fig. 13, it will also move the operating sleeve 148, and this action causes the collet member 146 to slide on the smooth outer surfaces of fingers 148 and thus compress the same to clamp the rubber tip 150. In this case, there may also be provided detents at 152 and corresponding projections at 154 in order to lightly secure the operating sleeve 140 to the piston rod 138 in order to provide for the temporary and light securement of these parts together in order to accomplish the aspirating function, but it is clear that a deliberate pull on piston rod 138 will release the detent and allow the retraction of the fingers to release the tip 150.
Figs. 14 and 15 illustrate a still further form of the invention but in this case the difference between the construction of Fig. 14 and the construction of Figs. 5 or resides in a circumferential series of parallel axially arranged corresponding serrations 156, so that the locking sleeve 158, which may be the same as that at 136 otherwise, will rotate the operating sleeve 160 relative to syringe piston rod 162 as the locking sleeve is rotated to bring it into locking engagement with the disposable cartridge or ampoule. Otherwise the construc tion and operation of the parts is the same as before but it will be appreciated that in all of the cases of Figs. 5, 10, 14 and 15, the piston rod for the syringe and the operating sleeve for the gripping fingers are capable of relative axial motion, but are relatively non-rotational when it is desired to lock the cartridge in place and to engage the gripping fingers with the rubber tip of the cartridge plunger.
This application is a continuation-in-part of my prior application Serial No. 442,494 filed July 12, 1954.
Having thus described my invention and the advantages thereof, 1 do not wish to be limited to the details herein disclosed, otherwise than as set forth in the claims, but what I claim is:
1. A syringe for use with a disposable ampoule cartridge having a plunger and said plunger having an exposed tip extending therefrom, said syringe comprising a barrel for receiving the cartridge, a needle and a piston rod associated with the barrel, and means on said piston rod for gripping the cartridge plunger tip for movement of the cartridge plunger with the piston rod in either direction for both aspiration and injection, the plunger tip gripping means comprising radially movable gripping fingers on the piston rod at the inner end there of and including means for moving said fingers radially inwardly to grip the tip, said fingers being resilient and normally retracted, the means for actuating the gripping fingers comprising a locking sleeve, a second sleeve ro tatable on the piston rod and non-rotatably associated with the locking sleeve for rotation by the locking sleeve, and inter-engaging means between said second sleeve and the gripping fingers moving said fingers radially inwardly upon relative axial motion thereof.
2. A syringe for use with a disposable ampoule cartridge having a plunger and said plunger having an exposed tip extending therefrom, said syringe comprising a barrel for receiving the cartridge, a needle and a piston rod associated with the barrel, and means on said piston rod for gripping the cartridge plunger tip for movement of the cartridge plunger with the piston rod in either direction for both aspiration and injection, the plunger tip gripping means comprising radially movable gripping fingers on the piston rod at the inner end thereof and including means for moving said fingers radially inwardly to grip the tip, said fingers being resilient and normally retracted, the means for actuating the gripping fingers comprising a locking sleeve, a. second sleeve rotatable on the piston rod and associated with the locking sleeve for rotation by the locking sleeve, inter-engaging means between said second sleeve and the gripping fingers moving said fingers radially inwardly upon relative axial motion thereof, and means to selectively engage or disengage the two sleeves for unirotational motion or separate, relative rotation with respect to each other.
References Cited in the file of this patent UNITED STATES PATENTS 1,929,247 Hein Oct. 3, 1933 2,413,303 Folkman Dec. 31, 1946 2,542,814 Hoskins Feb. 20', 1951 2,688,966 Huber Sept. 14, 1954 2,693,804 Pontius Nov. 9, 1954 FOREIGN PATENTS 620,824 Great Britain Mar. 30, 1949
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US479818A US2895474A (en) | 1955-01-04 | 1955-01-04 | Aspirating cartridge syringe |
GB19515/55A GB806703A (en) | 1955-01-04 | 1955-07-06 | Improvements in or relating to aspirating cartridge syringe |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US479818A US2895474A (en) | 1955-01-04 | 1955-01-04 | Aspirating cartridge syringe |
Publications (1)
Publication Number | Publication Date |
---|---|
US2895474A true US2895474A (en) | 1959-07-21 |
Family
ID=44962738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US479818A Expired - Lifetime US2895474A (en) | 1955-01-04 | 1955-01-04 | Aspirating cartridge syringe |
Country Status (2)
Country | Link |
---|---|
US (1) | US2895474A (en) |
GB (1) | GB806703A (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3348545A (en) * | 1964-10-22 | 1967-10-24 | Sarnoff | Latched cartridge |
US3495591A (en) * | 1967-05-08 | 1970-02-17 | Charles J Wilson | Method for administering injectable liquids |
US3878846A (en) * | 1971-12-13 | 1975-04-22 | Spad Lab | Hypodermic syringe with parts disposable after use |
US4701165A (en) * | 1986-03-26 | 1987-10-20 | Abbott Interfast Corp. | Reusable syringes |
US5137511A (en) * | 1987-07-08 | 1992-08-11 | Duoject Medical Systems Inc. | Syringe |
US5364369A (en) * | 1987-07-08 | 1994-11-15 | Reynolds David L | Syringe |
US5624400A (en) * | 1990-05-09 | 1997-04-29 | Safety Syringes, Inc. | Disposable self-shielding aspirating syringe |
US5634909A (en) * | 1993-12-09 | 1997-06-03 | Schmitz; William L. | Auto-retracting needle injector system |
WO2010125400A3 (en) * | 2009-05-01 | 2011-01-20 | Owen Mumford Limited | Injection devices |
WO2011042539A1 (en) * | 2009-10-08 | 2011-04-14 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for drug delivery devices |
US8372044B2 (en) | 2005-05-20 | 2013-02-12 | Safety Syringes, Inc. | Syringe with needle guard injection device |
US20130066279A1 (en) * | 2010-03-31 | 2013-03-14 | Sanofi-Aventis Deutschland Gmbh | Piston rod assembly for a drug delivery device |
US20160287790A1 (en) * | 2013-11-01 | 2016-10-06 | Alastair Willoughby | Medicament delivery device sub-assembly |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2009210184B2 (en) | 2008-01-28 | 2014-04-03 | Novo Nordisk A/S | Injection device for performing medical injections |
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US1929247A (en) * | 1931-01-20 | 1933-10-03 | George N Hein | Syringe equipment and apparatus |
US2413303A (en) * | 1944-01-17 | 1946-12-31 | Marvin L Folkman | Syringe |
GB620824A (en) * | 1947-01-15 | 1949-03-30 | Eugen Dolder | Improvements in or relating to hypodermic syringe and ampule |
US2542814A (en) * | 1946-10-17 | 1951-02-20 | Sterling Drug Inc | Hypodermic syringe |
US2688966A (en) * | 1951-10-06 | 1954-09-14 | Huber Jennie | Compartmented ampoule |
US2693804A (en) * | 1952-05-06 | 1954-11-09 | Hoechst Ag | Syringe casing for cylindrical ampoules |
-
1955
- 1955-01-04 US US479818A patent/US2895474A/en not_active Expired - Lifetime
- 1955-07-06 GB GB19515/55A patent/GB806703A/en not_active Expired
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1929247A (en) * | 1931-01-20 | 1933-10-03 | George N Hein | Syringe equipment and apparatus |
US2413303A (en) * | 1944-01-17 | 1946-12-31 | Marvin L Folkman | Syringe |
US2542814A (en) * | 1946-10-17 | 1951-02-20 | Sterling Drug Inc | Hypodermic syringe |
GB620824A (en) * | 1947-01-15 | 1949-03-30 | Eugen Dolder | Improvements in or relating to hypodermic syringe and ampule |
US2688966A (en) * | 1951-10-06 | 1954-09-14 | Huber Jennie | Compartmented ampoule |
US2693804A (en) * | 1952-05-06 | 1954-11-09 | Hoechst Ag | Syringe casing for cylindrical ampoules |
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3348545A (en) * | 1964-10-22 | 1967-10-24 | Sarnoff | Latched cartridge |
US3495591A (en) * | 1967-05-08 | 1970-02-17 | Charles J Wilson | Method for administering injectable liquids |
US3878846A (en) * | 1971-12-13 | 1975-04-22 | Spad Lab | Hypodermic syringe with parts disposable after use |
US4701165A (en) * | 1986-03-26 | 1987-10-20 | Abbott Interfast Corp. | Reusable syringes |
US5137511A (en) * | 1987-07-08 | 1992-08-11 | Duoject Medical Systems Inc. | Syringe |
US5364369A (en) * | 1987-07-08 | 1994-11-15 | Reynolds David L | Syringe |
US5624400A (en) * | 1990-05-09 | 1997-04-29 | Safety Syringes, Inc. | Disposable self-shielding aspirating syringe |
USRE37439E1 (en) * | 1990-05-09 | 2001-11-06 | Safety Syringes, Inc. | Disposable self-shielding aspirating syringe |
US5634909A (en) * | 1993-12-09 | 1997-06-03 | Schmitz; William L. | Auto-retracting needle injector system |
US8372044B2 (en) | 2005-05-20 | 2013-02-12 | Safety Syringes, Inc. | Syringe with needle guard injection device |
CN104353158A (en) * | 2009-05-01 | 2015-02-18 | 欧文蒙福德有限公司 | Injection devices |
WO2010125400A3 (en) * | 2009-05-01 | 2011-01-20 | Owen Mumford Limited | Injection devices |
JP2015097911A (en) * | 2009-05-01 | 2015-05-28 | オウエン マンフォード リミティド | Injection devices |
US9302054B2 (en) | 2009-05-01 | 2016-04-05 | Owen Mumford Limited | Injection devices |
CN104353158B (en) * | 2009-05-01 | 2017-07-18 | 欧文蒙福德有限公司 | Injection device |
WO2011042539A1 (en) * | 2009-10-08 | 2011-04-14 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for drug delivery devices |
JP2013507158A (en) * | 2009-10-08 | 2013-03-04 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Drive mechanism for drug delivery device |
US8900202B2 (en) | 2009-10-08 | 2014-12-02 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for drug delivery devices |
US20130066279A1 (en) * | 2010-03-31 | 2013-03-14 | Sanofi-Aventis Deutschland Gmbh | Piston rod assembly for a drug delivery device |
US9084852B2 (en) * | 2010-03-31 | 2015-07-21 | Sanofi-Aventis Deutschland Gmbh | Piston rod assembly for a drug delivery device |
US20160287790A1 (en) * | 2013-11-01 | 2016-10-06 | Alastair Willoughby | Medicament delivery device sub-assembly |
US10143803B2 (en) * | 2013-11-01 | 2018-12-04 | Consort Medical Plc | Medicament delivery device sub-assembly |
Also Published As
Publication number | Publication date |
---|---|
GB806703A (en) | 1958-12-31 |
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