US20240024100A1 - Heart valve stent and prosthetic heart valve structure thereof - Google Patents

Heart valve stent and prosthetic heart valve structure thereof Download PDF

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Publication number
US20240024100A1
US20240024100A1 US18/256,437 US202118256437A US2024024100A1 US 20240024100 A1 US20240024100 A1 US 20240024100A1 US 202118256437 A US202118256437 A US 202118256437A US 2024024100 A1 US2024024100 A1 US 2024024100A1
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Prior art keywords
heart valve
leaflet
joint member
stent
junction
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Pending
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US18/256,437
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English (en)
Inventor
Ryan HENIFORD
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Shanqian Zhuhai Biomaterials Technology Co Ltd
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Shanqian Zhuhai Biomaterials Technology Co Ltd
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Assigned to Shanqian (Zhuhai) Biomaterials Technology Co., Ltd. reassignment Shanqian (Zhuhai) Biomaterials Technology Co., Ltd. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HENIFORD, RYAN
Publication of US20240024100A1 publication Critical patent/US20240024100A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2409—Support rings therefor, e.g. for connecting valves to tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0057—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof stretchable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0091—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements connected by a hinged linkage mechanism, e.g. of the single-bar or multi-bar linkage type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0017—Angular shapes
    • A61F2230/0019—Angular shapes rectangular
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0029—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in bending or flexure capacity

Definitions

  • the present application relates to the field of medical devices, in particular relates to a heart valve stent and a prosthetic heart valve structure thereof.
  • prosthetic heart valve stents delivered through catheters only comprise metal components, such metal components are cut from thin-walled pipes by laser or are made from fine metal wires, the metal components are then adapted to construct the desired shape.
  • a prosthetic heart valve structure is obtained by fixing a heart valve to a prosthetic heart valve stent and assembling them together.
  • the heart valve can also be delivered through a small catheter with an inner diameter as low as 14 Fr, thus effectively implementing Transcatheter Aortic Valve Replacement (TAVR).
  • TAVR Transcatheter Aortic Valve Replacement
  • tissue of animal origin has elasticity similar to that of native valve tissue
  • tissue of animal origin is often used as a substitute material for valve leaflets to form a tissue heart valve.
  • tissue of animal origin which is often regarded as a “natural” material, has a limitation in its long-term durability, such a limitation is well documented in academic literature, clinical practice, and datasets. Therefore, Transcatheter Aortic Valve Replacement (TAVR) using a heart valve made of tissue of animal origin is generally not recommended for patients under 60 years of age.
  • TAVR Transcatheter Aortic Valve Replacement
  • one solution is to use synthetic materials known to have high durability and biocompatibility instead of leaflet materials.
  • synthetic materials are ideal materials due to their high strength and fatigue life, most synthetic materials have low elasticity, which limits their use in heart valve leaflet applications.
  • leaflet designs considered in the prior art are aimed to replicate the anatomical shape and function of native valves, as a leaflet assembly has two states of an open state and a closed state, and the heart valve stent is harder than leaflet materials, therefore, when the leaflet assembly is in a closed state, the leaflet junction of connection between the leaflet assembly and the heart valve stent will generate a certain amount of cyclic load, which would adversely affect its service life.
  • U.S. patent U.S. Ser. No. 10/524,902 B2 discloses a heart valve made of a leaflet material with significantly less elasticity than native tissue.
  • the specific assembly method between the leaflet assembly and the heart valve stent is as follows: the leaflet assembly comprises several leaflets and a suture ring that are integrally formed, a leaflet junction is located between every two adjacent leaflets in the leaflet assembly, and the leaflet junction is directly fixed to the suture ring and thereby fixed to the heart valve stent via the suture ring.
  • the above-mentioned structure only simulates and replicates the anatomical shape and function of a native valve.
  • each design described in the literature U.S. Ser. No. 10/524,902 B2 has stress concentration at the location where the leaflet junction is fixed to the suture ring, which greatly limits the service life of the valve.
  • the technical problem to be solved by the present application is to overcome the defect that the structural design in the prior art greatly limits the service life of the valve, so as to provide a stent and a prosthetic heart valve structure thereof that effectively reduce the stress concentration at the location where the leaflet junction is fixed to the suture ring, and thus prolong the service life thereof.
  • a heart valve stent is provided and comprises:
  • a joint member comprising a fixed part and an elastic stretching part connected to the fixed part, wherein an end of the elastic stretching part away from the fixed part is a movable end.
  • the joint member has a long strip shape.
  • a central axis of the joint member is parallel to a central axis of the stent body.
  • the elastic stretching part is connected to a leaflet junction, wherein the leaflet junction is a connection junction between every two adjacent leaflets in a heart valve prosthesis.
  • the length of the elastic stretching part is the same as the length of the leaflet junction; and/or the number of the joint member is the same as the number of the leaflet junction, wherein one joint member is fixed at each leaflet junction.
  • the joint member is formed by an elastic material with biocompatibility.
  • the fixed part is integrally formed with the elastic stretching part.
  • the elastic stretching part extends beyond the stent body in an axial direction of the stent body.
  • Cross-section of the elastic stretching part has a rectangular shape.
  • a prosthetic heart valve structure is provided and comprises:
  • a heart valve prosthesis comprising a leaflet assembly and a suture ring that fixes the leaflet assembly together, wherein the elastic stretching part is connected to a leaflet junction of the heart valve prosthesis which is a connection junction between every two adjacent leaflets of the leaflet assembly.
  • a prosthetic heart valve structure is provided and comprises:
  • a heart valve prosthesis comprising a leaflet assembly and a suture ring that fixes leaflet assembly together, wherein a connection junction between every two adjacent leaflets of the leaflet assembly forms a leaflet junction of the heart valve prosthesis;
  • a joint member comprising a fixed part and an elastic stretching part connected to the fixed part, wherein the fixed part is connected to the suture ring, and the elastic stretching part is connected to the leaflet junction.
  • the heart valve prosthesis is a woven fabric, and the joint member is arranged inside the woven fabric.
  • the fixed part of the joint member is located between the stent body and the suture ring.
  • the joint member has a long strip shape, and a central axis of the joint member is parallel to a central axis of the stent body; the length of the elastic stretching part is the same as the length of the leaflet junction.
  • the number of the joint member is the same as the number of the leaflet junction, wherein one joint member is fixed at each leaflet junction.
  • the joint member is formed by an elastic material with biocompatibility.
  • the structure of the present application can also cause the elastic stretching part between the leaflet junction and the joint member to tilt towards the center of the valve, which not only reduces stress and prolongs the service life, but also make it possible to use a material with lower elasticity to produce the leaflet assembly to achieve a valve performance comparable to that achieved by using a material with higher elasticity to produce the leaflet assembly in the prior art; meanwhile, the leaflet assembly is also enabled to close more quickly with less external force, which has significant effects.
  • FIG. 1 is a structural schematic diagram of the heart valve prosthesis in the open state after being mounted on a stent in the present application;
  • FIG. 2 is a top view of the structure shown in FIG. 1 ;
  • FIG. 3 is a structural schematic diagram of the heart valve prosthesis in the closed state after being mounted on a stent in the present application;
  • FIG. 4 is a top view of the structure shown in FIG. 3 ;
  • FIG. 5 is a schematic diagram of the structure of the joint member wrapped in the leaflet junction of the heart valve prosthesis in the present application
  • orientation or positional relationship indicated by the terms “center”, “top”, “bottom”, “left”, “right”, “vertical”, “horizontal”, “inside”, “outside”, etc. are based on the orientation or positional relationship shown in the drawings, which are only used for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation or be constructed and operated in a specific orientation, and therefore should not be understood as a limitation to the present application.
  • the terms “first”, “second” and “third” are only used for descriptive purposes and should not be understood as indicating or implying relative importance.
  • a heart valve stent as shown in FIGS. 1 and 2 , comprises a stent body 1 and a joint member 2 .
  • the joint member 2 comprises a fixed part and an elastic stretching part; the elastic stretching part is connected to the fixed part 1 through the fixed part; an end of the elastic stretching part away from the fixed part is a movable end; the movable end is used for connecting with a leaflet junction of a heart valve prosthesis 3 .
  • the elastic stretching part has an original state and a stretching state, wherein the movable end is tilted and shifted towards the center of the stent body in the stretching state.
  • a joint member 2 is added.
  • the fixed part of the joint member is fixed on the stent body, and one end of the elastic stretching part thereof is connected to the fixed part, while the other end of the elastic stretching part away from the fixed part is a movable end, which is used for connecting with a leaflet junction of the heart valve prosthesis.
  • a heart valve prosthesis 3 formed by a leaflet material with a fracture elongation of less than 20%, 10%, or 5%
  • the anchor point at the connection between the stent and the leaflet junction on the leaflet assembly is the joint member which has elasticity, the elastic stretching part of the joint member between the leaflet junction and the joint member 2 can be tilted towards the center of the valve, as shown in FIGS.
  • the fixed part may be a circular structure similar to the stent body or may be a structure of other shapes, as long as it is a structure that can be fixedly connected to the stent body 1 .
  • the elastic stretching part is used for connecting to the leaflet junction, and the connection manner includes, but is not limited to, sewing, bonding, welding, or mechanical connection.
  • the elastic stretching part is provided as a long strip structure, arranged along a connection seam between every two adjacent leaflets, that is, the elastic stretching part is fixed at the leaflet junction, and the number of elastic stretching parts is the same as the number of leaflets in the leaflet assembly.
  • the number of leaflets in an ordinary leaflet assembly is two or three, and the number of elastic stretching parts is correspondingly set to two or three.
  • the joint member 2 is overall arranged in a long strip shape, that is, the fixed part and the elastic stretching part are integrally formed.
  • One end of the joint member 2 is a fixed part for fixedly connecting to the stent body 1
  • the other end of the joint member 2 is an elastic stretching part with a movable end
  • the movable end is used for connection with the leaflet junction.
  • the heart valve prosthesis 3 is a tricuspid valve, and the number of leaflets is three, so the number of joint members 2 on the stent body 1 in the present embodiment is also set to three.
  • One joint member 2 is fixed at each of the leaflet junctions.
  • the movable end of the elastic stretching part may be lower than the position of the top of the stent body 1 in the axial direction of the stent body 1 , or may extend beyond the stent body 1 .
  • the elastic stretching part is set to extend beyond the stent body in the axial direction of the stent body, and meanwhile the length of the elastic stretching part can also be set to be the same as the length of the leaflet junction.
  • the heart valve prosthesis 3 may be fixed to the joint member 2 from an inner side of the stent body 1 , and the heart valve prosthesis 3 may also be fixed to the joint member 2 2 from an outer side of the stent body 1 .
  • the manner of fixing from an inner side is used to minimize the contour of the prosthetic heart valve structure when being delivered through a catheter and reduce the wall thickness of the instrument.
  • a portion of the joint member 2 may be exposed to the bloodstream, and meanwhile another portion of the joint member 2 may also be wrapped inside the heart valve prosthesis 3 .
  • the elastic stretching part can be wrapped in the leaflet junction of the heart valve prosthesis 3 by suturing.
  • the joint member 2 is preferably formed by an elastic material with biocompatibility, such as thermoplastic polyurethane rubber.
  • the joint member 2 is formed by extrusion or injection molding, and the material optimization can effectively reduce tissue rejection caused by surface exposure, such as collagen formation and thickening of the leaflet layer.
  • a section of the elastic stretching part perpendicular to the central axis thereof is the cross-section thereof.
  • the shape of the cross-section of the elastic stretching part may also vary, depending on the shape of the stent used and the connection manner between the leaflet of the heart valve prosthesis and the heart valve stent.
  • the cross-section of the elastic stretching part may be circular, square, polygonal, irregular, etc.
  • the cross-section of the elastic stretching part is set to have a rectangular shape and the elastic stretching part is connected to the leaflet junction in the heart valve prosthesis by bonding, which can effectively meet the requirement of minimum valve contour during delivery.
  • a prosthetic heart valve structure comprises a heart valve stent according to Embodiment 1 and a heart valve prosthesis 3 ; wherein the heart valve prosthesis 3 comprises a leaflet assembly 31 and a suture ring 32 that fixes the leaflet assembly 31 together, a connection junction between every two adjacent leaflets of the leaflet assembly 31 forms a leaflet junction of the heart valve prosthesis 3 .
  • connection manner between the heart valve prosthesis 3 and the heart valve stent is as follows: connecting the elastic stretching part of the heart valve stent to the leaflet junction of the heart valve prosthesis 3 , and meanwhile fixing the suture ring 32 of the heart valve prosthesis 3 to the stent body 1 of the heart valve stent.
  • the connection manner between the above-mentioned elastic stretching part and the leaflet junction, as well as the fixation manner between the above-mentioned suture ring 32 and the stent body 1 comprise but are not limited to sewing, bonding, welding, or mechanical connection.
  • a prosthetic heart valve structure comprises a stent body 1 , a heart valve prosthesis 3 , and a joint member 2 .
  • the heart valve prosthesis 3 comprises a leaflet assembly 31 and a suture ring 32 that fixes the leaflet assembly 31 together;
  • the joint member 2 comprises a fixed part and an elastic stretching part.
  • a connection junction between every two adjacent leaflets of the leaflet assembly 31 forms a leaflet junction of the heart valve prosthesis 3 .
  • the fixed part of the joint member 2 is connected to the suture ring 32 , and the elastic stretching part of the joint member 2 is connected to the leaflet junction.
  • the fixed part of the joint member 2 may be located between the stent body 1 and the suture ring 32 , or the suture ring 32 may also be arranged between the fixed part of the joint member 2 and the stent body 1 ; then it only requires to connect the elastic stretching part to the leaflet junction of the heart valve prosthesis 3 .
  • the joint member 2 may be fixed on the peripheral surface of the heart valve prosthesis 3 . It is only necessary to ensure that the fixed part is fixedly connected to the suture ring 32 and the elastic stretching part is fixedly connected to the leaflet junction.
  • the fixation of the joint member 2 on the stent body 1 can be effectively achieved; meanwhile, the elastic stretching part may also be embedded into the woven fabric forming the heart valve prosthesis 3 , that is, the elastic stretching part may be woven or sutured to the leaflet junction of the heart valve prosthesis 3 .
  • the joint member 2 in the present embodiment may be formed by an elastic material with biocompatibility, which effectively reduces tissue rejection inside the valve caused by foreign objects.
  • the structure of the joint member 2 connected to the stent body 1 through the suture ring 32 is described in detail in the present embodiment. Specifically, the joint member 2 is firstly fixed at the leaflet junction of the heart valve prosthesis 3 , and then it is connected to the stent body 1 through the suture ring 32 of the heart valve prosthesis 3 .
  • the heart valve prosthesis 3 is a woven fabric
  • the joint member 2 is provided to have a long strip shape, and the joint member 2 is sewn and wrapped inside the leaflet junction during the weaving process of the heart valve prosthesis 3 ;
  • the joint member 2 is provided as a single fiber structure, which is woven as a weft thread at the leaflet junction during the weaving process of the heart valve prosthesis 3 , the weft thread can be completely sealed into the leaflet junction of the leaflet assembly by using other fibers, thereby reducing tissue rejection related to high carbon materials inside the valve.
  • the leaflet junction of the heart valve prosthesis 3 incorporates the joint member 2 , so the thickness of the leaflet junction increases relatively. It is more convenient to assemble the heart valve prosthesis 3 on the stent due to the increase in thickness thereof, which effectively reduces the assembly time. Moreover, the increase in thickness at the leaflet junction can effectively reduce the positioning time for the heart valve prosthesis 3 , reduce the trimming and sewing work after assembly, and reduce the subsequent assembly workload, which has more significant effects.
  • the number of the joint member 2 is set to be the same as the number of the leaflet junction, and one joint member 2 is fixed at each leaflet junction. Moreover, a central axis of each joint member 2 is parallel to a central axis of the stent body 1 , and the length of the elastic stretching part is the same as the length of the leaflet junction.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
US18/256,437 2020-12-11 2021-01-07 Heart valve stent and prosthetic heart valve structure thereof Pending US20240024100A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202011463945.9A CN114617675A (zh) 2020-12-11 2020-12-11 一种心脏瓣膜支架及其构成的人工心脏瓣膜结构
CN202011463945.9 2020-12-11
PCT/CN2021/135962 WO2022121872A1 (fr) 2020-12-11 2021-12-07 Endoprothèse de valve cardiaque et structure de prothèse de valve cardiaque composée de celle-ci

Publications (1)

Publication Number Publication Date
US20240024100A1 true US20240024100A1 (en) 2024-01-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
US18/256,437 Pending US20240024100A1 (en) 2020-12-11 2021-01-07 Heart valve stent and prosthetic heart valve structure thereof

Country Status (5)

Country Link
US (1) US20240024100A1 (fr)
EP (1) EP4245258A4 (fr)
JP (1) JP2023553624A (fr)
CN (1) CN114617675A (fr)
WO (1) WO2022121872A1 (fr)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6454799B1 (en) * 2000-04-06 2002-09-24 Edwards Lifesciences Corporation Minimally-invasive heart valves and methods of use
US8845720B2 (en) * 2010-09-27 2014-09-30 Edwards Lifesciences Corporation Prosthetic heart valve frame with flexible commissures
RS60735B1 (sr) * 2010-10-05 2020-09-30 Edwards Lifesciences Corp Protetski srčani zalistak
CA2910602C (fr) * 2013-09-20 2020-03-10 Edwards Lifesciences Corporation Valvules cardiaques presentant une zone d'orifice effective augmentee
CN110090094B (zh) * 2014-05-06 2021-09-14 帝斯曼知识产权资产管理有限公司 人工瓣膜和制造人工瓣膜的方法
KR102478879B1 (ko) 2014-05-06 2022-12-16 디에스엠 아이피 어셋츠 비.브이. 인공 판막 및 인공 판막의 제조 방법
CN212089843U (zh) * 2020-02-18 2020-12-08 科凯(南通)生命科学有限公司 一种人工心脏瓣膜
CN214908660U (zh) * 2020-12-11 2021-11-30 山前(珠海)生物材料科技有限公司 一种心脏瓣膜支架及其构成的人工心脏瓣膜结构

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JP2023553624A (ja) 2023-12-25
CN114617675A (zh) 2022-06-14
EP4245258A1 (fr) 2023-09-20
WO2022121872A1 (fr) 2022-06-16
EP4245258A4 (fr) 2024-05-01

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