US20230392851A1 - Cooling element, shipping box with a cooling element, method for temperature stabilisation, and use of a cooling element - Google Patents
Cooling element, shipping box with a cooling element, method for temperature stabilisation, and use of a cooling element Download PDFInfo
- Publication number
- US20230392851A1 US20230392851A1 US18/249,267 US202118249267A US2023392851A1 US 20230392851 A1 US20230392851 A1 US 20230392851A1 US 202118249267 A US202118249267 A US 202118249267A US 2023392851 A1 US2023392851 A1 US 2023392851A1
- Authority
- US
- United States
- Prior art keywords
- volume
- container
- dry ice
- shipping box
- thermally insulated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000001816 cooling Methods 0.000 title claims abstract description 117
- 238000000034 method Methods 0.000 title claims abstract description 42
- 230000006641 stabilisation Effects 0.000 title claims abstract description 10
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 256
- 235000011089 carbon dioxide Nutrition 0.000 claims abstract description 97
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 93
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 93
- 239000003814 drug Substances 0.000 claims abstract description 14
- 229940126601 medicinal product Drugs 0.000 claims abstract description 12
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 12
- 230000000903 blocking effect Effects 0.000 claims abstract description 9
- 238000007789 sealing Methods 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 10
- 239000008280 blood Substances 0.000 claims description 6
- 210000004369 blood Anatomy 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 230000033228 biological regulation Effects 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 4
- 241000736262 Microbiota Species 0.000 claims description 3
- 108091034117 Oligonucleotide Proteins 0.000 claims description 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims description 3
- 239000000611 antibody drug conjugate Substances 0.000 claims description 3
- 229940049595 antibody-drug conjugate Drugs 0.000 claims description 3
- 238000002659 cell therapy Methods 0.000 claims description 3
- 238000001415 gene therapy Methods 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- 150000007523 nucleic acids Chemical class 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 239000001990 protein-drug conjugate Substances 0.000 claims description 3
- 150000003384 small molecules Chemical class 0.000 claims description 3
- 229960005486 vaccine Drugs 0.000 claims description 3
- 239000007787 solid Substances 0.000 abstract description 12
- 239000007789 gas Substances 0.000 description 74
- 229960004424 carbon dioxide Drugs 0.000 description 59
- 238000000859 sublimation Methods 0.000 description 19
- 230000008022 sublimation Effects 0.000 description 19
- 238000002474 experimental method Methods 0.000 description 17
- 239000003570 air Substances 0.000 description 11
- 241000533293 Sesbania emerus Species 0.000 description 9
- 239000012071 phase Substances 0.000 description 6
- 238000013459 approach Methods 0.000 description 5
- 238000010587 phase diagram Methods 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 5
- 239000003507 refrigerant Substances 0.000 description 5
- 239000008188 pellet Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 238000011105 stabilization Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000012080 ambient air Substances 0.000 description 2
- 239000012611 container material Substances 0.000 description 2
- 239000002826 coolant Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 229920001684 low density polyethylene Polymers 0.000 description 2
- 239000004702 low-density polyethylene Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000013022 venting Methods 0.000 description 2
- 208000034809 Product contamination Diseases 0.000 description 1
- 229920006328 Styrofoam Polymers 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000012782 phase change material Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008261 styrofoam Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Images
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
- F25D3/12—Devices using other cold materials; Devices using cold-storage bodies using solidified gases, e.g. carbon-dioxide snow
- F25D3/14—Devices using other cold materials; Devices using cold-storage bodies using solidified gases, e.g. carbon-dioxide snow portable, i.e. adapted to be carried personally
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/38—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation
- B65D81/3825—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation rigid container being in the form of a box, tray or like container with one or more containers located inside the external container
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D17/00—Arrangements for circulating cooling fluids; Arrangements for circulating gas, e.g. air, within refrigerated spaces
- F25D17/04—Arrangements for circulating cooling fluids; Arrangements for circulating gas, e.g. air, within refrigerated spaces for circulating air, e.g. by convection
- F25D17/042—Air treating means within refrigerated spaces
- F25D17/047—Pressure equalising devices
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
- F25D3/12—Devices using other cold materials; Devices using cold-storage bodies using solidified gases, e.g. carbon-dioxide snow
- F25D3/125—Movable containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2205/00—Venting means
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2205/00—Venting means
- B65D2205/02—Venting holes
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B2600/00—Control issues
- F25B2600/25—Control of valves
- F25B2600/2525—Pressure relief valves
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2303/00—Details of devices using other cold materials; Details of devices using cold-storage bodies
- F25D2303/08—Devices using cold storage material, i.e. ice or other freezable liquid
- F25D2303/082—Devices using cold storage material, i.e. ice or other freezable liquid disposed in a cold storage element not forming part of a container for products to be cooled, e.g. ice pack or gel accumulator
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2303/00—Details of devices using other cold materials; Details of devices using cold-storage bodies
- F25D2303/08—Devices using cold storage material, i.e. ice or other freezable liquid
- F25D2303/082—Devices using cold storage material, i.e. ice or other freezable liquid disposed in a cold storage element not forming part of a container for products to be cooled, e.g. ice pack or gel accumulator
- F25D2303/0821—Devices using cold storage material, i.e. ice or other freezable liquid disposed in a cold storage element not forming part of a container for products to be cooled, e.g. ice pack or gel accumulator the element placed in a compartment which can be opened without the need of opening the container itself
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2303/00—Details of devices using other cold materials; Details of devices using cold-storage bodies
- F25D2303/08—Devices using cold storage material, i.e. ice or other freezable liquid
- F25D2303/084—Position of the cold storage material in relationship to a product to be cooled
- F25D2303/0843—Position of the cold storage material in relationship to a product to be cooled on the side of the product
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2303/00—Details of devices using other cold materials; Details of devices using cold-storage bodies
- F25D2303/08—Devices using cold storage material, i.e. ice or other freezable liquid
- F25D2303/084—Position of the cold storage material in relationship to a product to be cooled
- F25D2303/0844—Position of the cold storage material in relationship to a product to be cooled above the product
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2303/00—Details of devices using other cold materials; Details of devices using cold-storage bodies
- F25D2303/08—Devices using cold storage material, i.e. ice or other freezable liquid
- F25D2303/084—Position of the cold storage material in relationship to a product to be cooled
- F25D2303/0845—Position of the cold storage material in relationship to a product to be cooled below the product
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
- F25D3/02—Devices using other cold materials; Devices using cold-storage bodies using ice, e.g. ice-boxes
- F25D3/06—Movable containers
Definitions
- the present invention relates to a cooling element according to the preamble of claim 1 . Additionally, the invention relates to a shipping box comprising one or more cooling elements. Moreover, the invention relates to a method for temperature stabilization. Also, the invention relates to a use of such a method or cooling element or shipping box.
- Low-temperature product shipments are often done using dry ice (frozen or solid carbon dioxide) as a refrigerant. In equilibrium, under atmospheric conditions, the sublimation temperature of dry ice is around ⁇ 78.5° C.
- These shipments consist of a thermally insulated shipping box containing dry ice pellets, the product to be shipped and a temperature logger. The product and logger are fully covered by dry ice on all sides.
- shipments are sometimes done at higher temperatures, such as ⁇ 20° C.
- Such shipments require the use of packs of selected phase-change material(s) as a refrigerant material.
- this approach is more complex and costly than the use of dry ice as refrigerant. Additionally, not all products are compatible with shipments at these elevated temperatures.
- a cooling element comprising a container, the container defining a volume within one or more walls of the container; the volume being air-tight sealed, wherein the container contains dry ice (solid carbon dioxide) and is configured for releasing carbon dioxide gas from the volume and blocking ingress of ambient gas into the volume.
- the cooling element as defined above overcomes the temperature excursion issue by providing that in the container filled with dry ice the gas volume is consisting of carbon dioxide is maintained at a constant composition without disturbance from ambient gases, i.e., by mixing with variable amounts of ambient gases. Additionally, the provision for the release of carbon dioxide gas allows the internal pressure to remain constant and equal or near ambient pressure. As a result, the equilibrium between the solid phase and the gas phase of carbon dioxide (CO 2 ) remains constant by maintaining the CO 2 partial pressure at a constant level. A constant CO 2 partial pressure prevents excessive sublimation of carbon dioxide relative to the ‘normal’ sublimation required for remaining at the sublimation point. Since the sublimation reaction is endothermic, excessive sublimation would be accompanied by strong cooling below the equilibrium temperature, which is ⁇ 78.5° C. at atmospheric pressure (1 atm, ⁇ 1013 hPa).
- the invention provides a cooling element as described above wherein the material of the container walls is selectively permeable for carbon dioxide gas.
- carbon dioxide can be released from the container by diffusion through the wall(s) of the container.
- the container material allows that the internal pressure can be regulated in this manner, while preventing entry of ambient gas into the internal volume, which would alter the equilibrium conditions between CO 2 gas and dry ice.
- the invention provides a cooling element as described above wherein the container comprises a one-way valve for releasing gas from the internal volume.
- the one-way valve allows the release of carbon dioxide gas from the container, while preventing entry of ambient gas into the internal volume.
- the invention provides a cooling element as described above wherein the one-way valve is an overpressure release valve.
- the release pressure can be predetermined which allows to control the pressure of CO 2 in contact with the dry ice and thus the sublimation temperature.
- the one-way valve is configured to release carbon dioxide gas from the internal volume at an internal overpressure relative to ambient pressure.
- the invention provides a cooling element as described above wherein the material of the container is a flexible material.
- a receptacle an object with an internal volume for holding a product can be surrounded by/wrapped in the cooling element, improving the thermal contact such that better cooling of the product can be obtained.
- the invention provides a cooling element as described above wherein the volume of the container is configured for containing between about 50 grams and about 20 kilograms of carbon dioxide dry ice.
- the invention provides a cooling element as described above wherein the carbon dioxide dry ice is provided in the form of dry ice pellets.
- the dry ice has a relative large surface which allows that an equilibrium between gas and solid carbon dioxide can be obtained at relatively high rate.
- the present invention relates to a shipping box comprising a thermally insulated volume therein, and configured for holding a product or a receptacle holding a product and one or more cooling elements as described above, wherein the one or more cooling elements are arranged to enclose the product or the receptacle holding the product.
- the invention relates to a shipping box comprising a thermally insulated volume therein, and configured for holding at least one receptacle and one or more cooling elements as described above, wherein the one or more cooling elements are arranged to enclose the receptacle.
- the shipping box is configured to maintain its temperature at carbon dioxide sublimation temperature ( ⁇ 78.5° C. at 1 atm) without the risk of temperature changes to lower temperatures of about ⁇ 85° C.
- the invention provides a shipping box as described above wherein the shipping box is configured with thermally insulating walls and cover surrounding the thermally insulated volume.
- the invention provides a shipping box as described above wherein the thermally insulated volume is configured to have an internal pressure equal to external air pressure.
- the shipping box is arranged to have a same internal pressure as the ambient which is useful in environments where expected pressure changes are relatively small.
- the invention provides a shipping box as described above wherein the thermally insulated volume is an air-tight volume and the shipping box comprises a pressure relief valve for releasing gas from the thermally insulated volume.
- the release pressure for carbon dioxide from the cooling element and the internal pressure of the cooling element can be pre-set which provides that a better control of the temperature in the cooling element.
- the invention provides a shipping box as described above wherein a temperature logger is placed in the thermally insulated volume adjoining the receptacle for holding a product, and the one or more cooling elements are arranged to enclose both the receptacle and the temperature logger.
- the invention provides a shipping box as described above, wherein the receptacle comprises a vial containing a (bio)pharmaceutical substance or advanced therapy medicinal product, and the vial is provided with a rubber stopper.
- the invention provides a shipping box as described above, wherein the (bio)pharmaceutical substance or advanced therapy medicinal product comprise one or more substances selected from a group comprising small molecules, oligonucleotides, nucleic acids, peptides, proteins, antibodies, protein or antibody-drug conjugates, gene therapy, cell therapy, vaccines, blood or blood-derived components and microbiota derived products.
- the (bio)pharmaceutical substance or advanced therapy medicinal product comprise one or more substances selected from a group comprising small molecules, oligonucleotides, nucleic acids, peptides, proteins, antibodies, protein or antibody-drug conjugates, gene therapy, cell therapy, vaccines, blood or blood-derived components and microbiota derived products.
- the present invention also relates to a method for temperature stabilisation of a product contained in one or more receptacles, during shipment in dry ice, comprising: providing a shipping box comprising a thermally insulated volume therein; placing one or more cooling elements and a receptacle holding a product in the thermally insulated volume, while arranging the one or more cooling elements to enclose the one or more receptacles, in which each cooling element comprises a container, the container defining an internal volume within one or more walls of the container; the internal volume being air-tight sealed and filled with dry ice, wherein the container is configured for releasing carbon dioxide gas from the volume and for blocking ingress of ambient gas into the volume;
- the method further comprising: releasing carbon dioxide gas from the internal volume of the container at a predetermined overpressure of the carbon dioxide gas relative to ambient pressure.
- the present invention also relates to a method for temperature stabilisation of one or more receptacles during shipment in dry ice, comprising: providing a shipping box comprising a thermally insulated volume therein; placing one or more cooling elements and a receptacle holding a product in the thermally insulated volume, while arranging the one or more cooling elements to enclose the one or more receptacles, in which each cooling element comprises a container, the container defining an internal volume within one or more walls of the container; the internal volume being air-tight sealed and filled with dry ice, wherein the container is configured for releasing carbon dioxide gas from the volume and for blocking ingress of ambient gas into the volume;
- the method further comprising: releasing carbon dioxide gas from the internal volume of the container at a predetermined overpressure of the carbon dioxide gas relative to ambient pressure.
- the invention provides a method as described above wherein the material of the container walls is selectively permeable for carbon dioxide gas.
- the invention provides a method as described above wherein the method comprises providing the container with a one-way valve for releasing carbon dioxide gas from the internal volume.
- the invention provides a method as described above wherein the one-way valve is configured as an overpressure valve.
- the invention provides a method as described above wherein the method comprises maintaining a pressure in the thermally insulated volume at ambient pressure.
- the invention provides a method as described above wherein the method comprises: providing the thermally insulated volume as an air-tight volume and providing the shipping box with a pressure relief valve for releasing gas from the thermally insulated volume for maintaining a constant pressure in the thermally insulated volume.
- the invention provides a method as described above wherein the method comprises: arranging a temperature logger in the thermally insulated volume adjoining the receptacle for holding the product, and the temperature logger is also enclosed by the one or more cooling elements.
- the invention provides a method as described above wherein the method further comprises: maintaining a temperature in the thermally insulated volume at the sublimation temperature of carbon dioxide, while dry ice is present in the one or more cooling elements.
- the invention provides a method as described above wherein the method comprises: preceding the placement of one or more cooling elements and a product in the thermally insulated volume of the shipping box: providing the container of the cooling elements with an opening to access the internal volume of the cooling elements; filling the internal volume of the cooling elements with dry ice through the opening; air-tight sealing the opening after filling the internal volume with dry ice; and providing the container of the cooling elements with a pressure regulation means.
- the invention provides a method as described above wherein the method comprises: preceding the placement of one or more cooling elements and one or more receptacles in the thermally insulated volume of the shipping box: providing the container of the cooling elements with an opening to access the internal volume of the cooling elements; filling the internal volume of the cooling elements with dry ice through the opening; air-tight sealing the opening after filling the internal volume with dry ice; and providing the container of the cooling elements with a pressure regulation means.
- the invention provides a method as described above wherein the method comprises: preceding the placement of one or more cooling elements and a product in the thermally insulated volume of the shipping box: providing the container of the cooling elements with an opening to access the internal volume of the cooling elements; filling the internal volume of the cooling elements with dry ice through the opening; air-tight sealing the opening after filling the internal volume with dry ice; and maintaining a small opening in the air-tight sealing for releasing carbon dioxide gas from the internal volume and for blocking ingress of ambient gas into the volume.
- the invention provides a method as described above wherein the method comprises: preceding the placement of one or more cooling elements and one or more receptacles in the thermally insulated volume of the shipping box: providing the container of the cooling elements with an opening to access the internal volume of the cooling elements; filling the internal volume of the cooling elements with dry ice through the opening; air-tight sealing the opening after filling the internal volume with dry ice; and maintaining a small opening in the air-tight sealing for releasing carbon dioxide gas from the internal volume and for blocking ingress of ambient gas into the volume.
- the invention provides for the use of a cooling element as defined above for the shipment in dry ice of at least one receptacle holding a product comprising a (bio)pharmaceutical substance or advanced therapy medicinal product.
- the invention also provides for the use of a cooling element as defined above for the shipment in dry ice of at least one receptacle holding a product comprising a (bio)pharmaceutical substance or advanced therapy medicinal product, wherein during the shipment in dry ice there is a temperature stabilization of the product contained in said at least one receptacle; wherein there is a shipping box comprising a thermally insulated volume therein; wherein there is one or more cooling elements as defined above and at least one receptacle in the thermally insulated volume; and wherein the one or more cooling elements are arranged to enclose the one or more receptacles.
- the invention provides for the use of a shipping box as defined above for the shipment of at least one receptacle holding a product comprising a (bio)pharmaceutical substance or advanced therapy medicinal product. Additionally or alternatively, the invention provides for the use of a method for temperature stabilisation as defined above for the shipment of at least one receptacle holding a product comprising a (bio)pharmaceutical substance or advanced therapy medicinal product(s).
- FIG. 1 schematically shows a cooling element according to an embodiment of the invention.
- FIGS. 2 and 3 schematically show a cooling element according to an embodiment of the invention.
- FIG. 4 schematically shows a shipping box according to an embodiment of the invention.
- FIG. 5 shows the carbon dioxide phase diagram
- FIG. 6 Carbon dioxide phase diagram of the region of interest (a) and change of CO 2 concentration occurring when another gas enters the shipment box (b).
- FIG. 7 Representation of a standard CB-EPS- 24 transportation box.
- FIG. 8 Schematic representation of the conventional approach ( FIG. 8 A ) and new approach tested in the exploratory study described in the example ( FIG. 8 B ).
- FIG. 9 Sealed CO 2 valve bag for packing entire dry-ice content during shipment. One-way valve let CO 2 gas out and prevents temperature drop in the box.
- FIG. 10 A Two pouches filled with dry ice and the thermocouples in a CBS-EPS-24 box.
- C CB-EPS-24 box filled directly with dry-ice with thermocouple placement.
- FIG. 11 A: The freezer bags used for the experiment. Note the partially closed sealing zipper for CO 2 venting.
- FIG. 12 This experiment compared the temperature in a shipping box filled with dry ice ( FIG. 12 A ) to the temperature in a box filled with dry ice-containing sealed “coffee bean” bags ( FIG. 12 B ). During the first two hours of the experiment the shipping box was closed. After two hours, two air holes (15 mm diameter) were punched diagonally across from each other in the sides (walls) of each of the boxes, allowing an airflow to circulate through the boxes.
- FIG. 13 This experiment compared the temperature in a shipping box filled with dry ice ( FIG. 13 A ) to the temperature in a box filled with dry ice-containing sealable freezer bags
- FIG. 13 B ( FIG. 13 B ).
- the shipping box was closed.
- two air holes (15 mm diameter) were punched diagonally across from each other in the sides (walls) of each of the boxes, allowing an airflow to circulate through the boxes.
- FIG. 1 schematically shows a cooling element 10 according to an embodiment of the invention.
- the cooling element 10 of the invention comprises a container 20 which is configured to hold carbon dioxide in an internal volume 30 of the container.
- the internal volume is defined by the walls of the container and is configured to be air-tight sealable.
- the container is provided with a pressure regulation means 25 to provide that an internal pressure in the internal volume 30 can be regulated, i.e., kept substantially constant.
- the internal volume can be filled with solid carbon dioxide (dry ice) as refrigerant.
- dry ice solid carbon dioxide
- the pressure regulation 25 of the cooling element provides that the pressure of the carbon dioxide gas is maintained at a substantially constant pressure to avoid an overpressure that can deform or damage the container of the cooling element.
- the walls 20 of the container are or comprise selectively permeable membranes 25 for carbon dioxide gas which allow that carbon dioxide gas can diffuse from the internal volume to the outside of the container (for example the ambient).
- a one-way gas release valve 25 can be arranged in a wall of the container to release gas from the internal volume at a predetermined internal pressure.
- the one-way valve can be an overpressure release valve.
- the cooling element can be embodied in various manners as explained below in more detail.
- FIG. 2 schematically show a cooling element 10 according to an embodiment of the invention.
- the container is a pouch made from flexible material such as a plastic that is filled with dry ice and carbon dioxide gas.
- the pouch comprises a one-way gas release valve 25 as described above.
- Such a pouch is a member of a plurality of similar or identical pouches that are designed to be placed adjacent to a receptacle for a product (not shown) such as a vial, bottle or box. To obtain cooling, the receptacle is surrounded by a plurality of the pouches which thermally isolate the receptacle and its contents from the environment.
- FIG. 3 schematically shows a cooling element 12 according to an embodiment of the invention.
- the cooling element comprises a flexible or deformable pouch capable of containing dry ice and carbon dioxide gas and which is designed to be wrapped or folded around a receptacle 40 . In this manner cooling of the receptacle can be done by means of a single cooling element.
- the cooling element is designed as a sleeve in which the product can be inserted.
- the internal volume 30 of the cooling element 12 is formed in between the inner and outer walls 22 , 24 of the sleeve.
- the cooling element can have various sizes and shapes depending on the application: the internal volume can be configured to contain between about 50 grams and about 20 kilograms of dry ice.
- the dry ice is provided in the form of dry ice pellets.
- the internal volume 30 of the cooling element 10 ; 12 is filled with dry ice and subsequently air-tight sealed.
- FIG. 4 schematically shows a shipping box 50 according to an embodiment of the invention.
- the shipping box is arranged for transport of receptacle(s) ( 40 ) for holding product(s) that require cooling to avoid exposure to varying and/or relatively high temperature.
- the shipping box comprises bottom, top and side walls 52 , 54 , 56 that form an enclosure which defines a shipping volume 58 for holding the receptacle(s) 40 .
- the top wall of the shipping box is a removable cover to provide access to a top opening of the shipping volume.
- the walls 52 , 54 , 56 are constructed from or comprise thermal insulating material to provide thermal insulation of the shipping volume.
- one or more cooling elements 10 ; 12 as described above can be arranged.
- the receptacle(s) 40 is (are) placed in the shipping volume 58 in a manner that the receptacle is enveloped or surrounded by the one or more cooling elements.
- the receptacle can be wrapped in a foldable cooling element and then placed in the shipping box.
- the receptacle and cooling elements are stacked in the shipping volume in a manner that the receptacle is surrounded on substantially all sides by the cooling elements.
- a temperature logging device 60 may be included with the receptacle(s)
- the receptacle(s) and the logger device are in a package that is surrounded by the cooling element(s) 10 ; 12 .
- the shipping box 50 as shown in FIG. 4 is oriented in upright position.
- the dry ice absorbs heat, sublimation of CO 2 takes place within the internal volume of the cooling element(s) 10 ; 12 and the amount of carbon dioxide gas in the internal volume 30 increases.
- the pressure in the internal volume 30 is regulated and excess carbon dioxide gas is released into the shipping volume 58 which is separated from the internal volume 30 of the cooling element(s). Most of the released carbon dioxide gas is accumulating in the shipping volume. However due to the separation the carbon dioxide gas in the shipping volume is not included in the equilibrium reaction of the carbon dioxide gas and the dry ice in the cooling elements. The reaction between the carbon dioxide gas and the dry ice is contained in the cooling elements and isolated from the ambient.
- the shipping box 50 may be an air-tight sealable box.
- the shipping box In order to prevent overpressure in the shipping volume, the shipping box is provided with an overpressure valve (not shown) to release carbon dioxide gas from the shipping volume.
- the shipping box may comprise one or more through-holes (not shown) in the walls to reduce the overpressure relative to the ambient pressure.
- the top opening of the shipping box is not horizontally levelled, and in this orientation, carbon dioxide gas can flow out from the shipping box into the ambient.
- ambient gas can enter the shipping volume.
- the ambient gas will not enter the internal volume 30 .
- the shipping box is used for transport or shipment of receptacles 40 such as vials 42 containing a (bio)pharmaceutical substance that requires cooling to prevent deterioration.
- receptacles 40 such as vials 42 containing a (bio)pharmaceutical substance that requires cooling to prevent deterioration.
- Such (bio)pharmaceuticals may comprise one or more substances selected from a group comprising small molecules, oligonucleotides, nucleic acids, peptides, proteins, antibodies, protein or antibody-drug conjugates, gene therapy, cell therapy, vaccines, blood or blood-derived components and microbiota derived products.
- ATMPs advanced therapy medicinal products
- the invention relates to a method for temperature stabilisation of one or more receptacles 40 during shipment in dry ice, which comprises —providing a shipping box 50 that comprises a thermally insulated volume 58 therein; —placing one or more cooling elements 10 ; 12 and the one or more receptacles 40 in the thermally insulated volume, while arranging the one or more cooling elements to enclose the product, in which each cooling element comprises a container 20 , the container defining an internal volume 30 within one or more walls of the container; the internal volume 30 is air-tight sealed and filled with dry ice, and the container is configured for releasing carbon dioxide gas from the volume and for blocking ingress of ambient gas into the volume.
- the method further comprises releasing carbon dioxide gas from the internal volume of the container at a predetermined overpressure of the carbon dioxide gas relative to ambient pressure.
- the method above can be used for the transportation or shipment of receptacles such as vials containing (bio)pharmaceuticals as described above.
- FIG. 5 shows the carbon dioxide phase diagram.
- the phase diagram shows the phases (solid 100 , liquid 105 , gas 110 ) of carbon dioxide as a function of temperature and pressure.
- the phases are separated by binary phase lines: carbon dioxide gas and solid are separated by a sublimation line 120 , gas and liquid by a saturation line 130 and solid and liquid by a melting line 140 .
- the sublimation line, saturation line and melting line meet at a triple point 150 .
- the sublimation temperature of dry ice at 1 atm is only ⁇ 78.5° C. when considering a 100% CO 2 atmosphere in equilibrium with dry ice.
- the temperature of a gaseous/solid CO 2 system can drop below ⁇ 78.5° C. in two situations: when the absolute pressure drops below 1 atm, while maintaining a 100% CO 2 concentration (i.e. during air transport), or when the relative concentration of CO 2 drops below 100% while maintaining an absolute pressure of 1 atm (i.e. during mixing with other gases).
- the present invention prevents relatively large temperature excursions below the atmospheric sublimation point of carbon dioxide at ⁇ 78.5° C. by application of the cooling element as described above.
- the temperature of a receptacle and product i.e., a rubber stopped vial 42 , 44 and substance in the vial
- the risk of an impaired sealing integrity of rubber stopped 44 vials 42 is reduced.
- the invention also provides for the use of a cooling element as defined above for the shipment in dry ice of at least one receptacle holding a product comprising a (bio)pharmaceutical substance or advanced therapy medicinal product, wherein during the shipment in dry ice there is a temperature stabilization of the product contained in said at least one receptacle ( 40 ); wherein there is a shipping box ( 50 ) comprising a thermally insulated volume ( 58 ) therein; wherein there is one or more cooling elements ( 10 , 12 ) as defined above and at least one receptacle ( 40 ) in the thermally insulated volume ( 58 ); and wherein the one or more cooling elements ( 10 , 12 ) are arranged to enclose the at least one receptacle ( 40 ).
- Dry ice solid carbon dioxide, CO 2
- CO 2 solid carbon dioxide
- a shipment box dry ice is usually surrounded by 100% gaseous CO 2 , at an ambient pressure of 1 bar.
- the partial pressure drops ( FIG. 6 ) and therefore also the temperature of the cooling agent.
- an imperfect sealing of a shipment box can cause CO2 gas from dry ice to escape from the box and to be substituted by air which comes in contact with dry ice inside the box.
- the boxes were closed and first allowed to equilibrate in the absence of any air leaks for a period of one to two hours, with the thermocouple datalogger running. After that initial period, two air holes (15 mm diameter) were punched diagonally across from each other in the sides (walls) of each of the boxes, allowing an airflow to circulate through the boxes. The boxes were left in this state overnight.
- the one-way vented (coffee bean) bags were relatively large in view of the interior of the shipping box, making it difficult to completely fill the box with these bags. Gaps between the bags were large so the box with bags contained significantly less dry ice than the box that was filled with dry ice directly (estimated to be less than half the amount of dry ice, by weight). Also, some areas of the box (upper edges) did not fit an additional bag and thus contained air gaps ( FIG. 10 ). Because of this sub-optimal configuration, the experiment was repeated using standard sealable 1.5 L plastic freezer bags ( FIG. 11 ). These bags were smaller and made of a thinner, more flexible material (e.g. low density Polyethylene (LDPE)), allowing a better filling of the box. 16 of the plastic freezer bags were used to fill a shipping box. The required venting of the bags was achieved by only partially closing the seal strip, leaving an opening of 2 cm in length.
- LDPE low density Polyethylene
- thermocouple The temperature change in the box containing partly sealed dry ice bags was smaller, showing a very low temperature drop measured by the thermocouple at 8 cm, while the thermocouples at 2 cm and 14 cm measured a small rise in temperature ( FIG. 13 B ).
- the temperature profile looked slightly more stable for the freezer bags than for the coffee pouches.
- the top thermocouple (20 cm) in both boxes showed a much higher temperature because it was located above the level of the dry ice. The warming of the temperature due to the incoming air caused by the leak can clearly be seen in the upper thermocouple.
- the second type of pouch was tested after encountering several practical issues with the available coffee bean bags (size, seal, surface area, material thickness, thermal conductance, packing efficiency). Indeed, a slightly more stable interior temperature was achieved using the smaller and thinner freezer bags.
- the experiments have also shown that a one-way valve is not strictly necessary and may be replaced by a small vent hole or opening in the pouch. As long as the vent hole or opening is small, CO 2 that escapes through the hole or opening will prevent the ingress of ambient air into the pouch, thus providing a functionality similar to the one-way valve.
- the important features of the present invention are thus 1 ) the non-permeable pouch, combined with 2 ) a feature that allows the escape of gaseous CO 2 .
Landscapes
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Mechanical Engineering (AREA)
- Combustion & Propulsion (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Packages (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20202866 | 2020-10-20 | ||
EP20202866.8 | 2020-10-20 | ||
PCT/EP2021/078933 WO2022084307A1 (fr) | 2020-10-20 | 2021-10-19 | Élément de refroidissement, boîte d'expédition dotée d'un élément de refroidissement, procédé de stabilisation de température et utilisation d'un élément de refroidissement |
Publications (1)
Publication Number | Publication Date |
---|---|
US20230392851A1 true US20230392851A1 (en) | 2023-12-07 |
Family
ID=72964582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US18/249,267 Pending US20230392851A1 (en) | 2020-10-20 | 2021-10-19 | Cooling element, shipping box with a cooling element, method for temperature stabilisation, and use of a cooling element |
Country Status (3)
Country | Link |
---|---|
US (1) | US20230392851A1 (fr) |
EP (1) | EP4232375A1 (fr) |
WO (1) | WO2022084307A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT526147B1 (de) * | 2022-08-19 | 2023-12-15 | Rep Ip Ag | Verpackung für pharmazeutische Erzeugnisse |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5547694A (en) * | 1993-03-23 | 1996-08-20 | The Pillsbury Company | Container for refrigeratable yeast-leavened doughs |
US20090193765A1 (en) * | 2005-09-07 | 2009-08-06 | Gary Lantz | Variable-volume insulated shipping container |
-
2021
- 2021-10-19 US US18/249,267 patent/US20230392851A1/en active Pending
- 2021-10-19 EP EP21794817.3A patent/EP4232375A1/fr active Pending
- 2021-10-19 WO PCT/EP2021/078933 patent/WO2022084307A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP4232375A1 (fr) | 2023-08-30 |
WO2022084307A1 (fr) | 2022-04-28 |
WO2022084307A9 (fr) | 2023-05-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5780691B2 (ja) | 輸送コンテナ等における内部温度の維持方法および装置 | |
US6336340B1 (en) | Storage container for storage of temperature sensitive materials during transport | |
US10625922B2 (en) | Device and methods for transporting temperature-sensitive material | |
ES2651241T3 (es) | Métodos y aparatos de empaquetado en vacío para tabaco | |
US8904810B2 (en) | Temperature control transport system | |
US6119465A (en) | Shipping container for storing materials at cryogenic temperatures | |
González et al. | Determination of O2 and CO2 transmission rates through microperforated films for modified atmosphere packaging of fresh fruits and vegetables | |
US20230392851A1 (en) | Cooling element, shipping box with a cooling element, method for temperature stabilisation, and use of a cooling element | |
CN207312137U (zh) | 一种试剂瓶转移收纳盒 | |
US11879595B2 (en) | Cryosphere | |
US6675605B2 (en) | Method and device for transporting equine semen | |
US10351326B2 (en) | Storage of temperature-sensitive items with stabilizing pellets | |
US20060172044A1 (en) | Method for storing and shipping fruit and container for use with said method | |
WO2017091394A1 (fr) | Boîte de transport de produit alimentaire jetable et poche de glace | |
WO2014127213A1 (fr) | Emballage et procédé de remplissage pour limiter l'aspect de brique | |
JP2014136593A (ja) | 保冷包装体、及び梱包体 | |
CN202897176U (zh) | 半导体晶片的无湿气包装 | |
Lee et al. | Effect of packaging conditions on keeping quality of fresh jujube | |
US11519657B1 (en) | Dry ice containing shippers | |
US20190098918A1 (en) | Packaging with pressure driven oxygen egress | |
US20230108589A1 (en) | Dry Ice Containing Shippers | |
FI13459Y1 (fi) | Koestuskammio materiaalin lujuusominaisuuksien määrittämiseksi | |
US20230404068A1 (en) | Methods and devices for thermal stabilization on perishable biological specimens | |
CN117897582A (zh) | 改进的包含干冰的装运器 | |
GB2618658A (en) | An insulating transport and storage container |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: JANSSEN VACCINES & PREVENTION B.V., NETHERLANDS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:HARVEY NASH B.V.;REEL/FRAME:063341/0297 Effective date: 20211221 Owner name: JANSSEN VACCINES & PREVENTION B.V., NETHERLANDS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:CAPELLE, MARTINUS ANNE HOBBE;REEL/FRAME:063341/0282 Effective date: 20211019 Owner name: HARVEY NASH B.V., NETHERLANDS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:DE JONG, HENDRIK JAN;REEL/FRAME:063341/0239 Effective date: 20211019 |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |