Classifications

• • A—HUMAN NECESSITIES
  • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
  • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
  • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
  • A24B15/18—Treatment of tobacco products or tobacco substitutes
  • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
  • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
  • A24B15/32—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by acyclic compounds
• • A—HUMAN NECESSITIES
  • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
  • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
  • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
  • A24B15/10—Chemical features of tobacco products or tobacco substitutes
  • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
• • A—HUMAN NECESSITIES
  • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
  • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
  • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
  • A24B15/18—Treatment of tobacco products or tobacco substitutes
  • A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
  • A24B15/241—Extraction of specific substances
  • A24B15/243—Nicotine
• • A—HUMAN NECESSITIES
  • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
  • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
  • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
  • A24B15/18—Treatment of tobacco products or tobacco substitutes
  • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
  • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
  • A24B15/302—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by natural substances obtained from animals or plants

Definitions

• the present invention relates to an aerosol-generating substrate and its manufacturing method.
• the invention also relates to an aerosol-generating article comprising the aerosol-generating substrate.
• aerosol-forming substrate is heated at a rather relatively low temperature, for instance below 350° C., to avoid combustion thereof.
• a charge of inhalable aerosol can then be released from the aerosol-generating article.
• the aerosol released is originated from the aerosol formers, which are incorporated into the tobacco material, which may be particulated or granulated.
• coughing also known as coughing fit
• the inventors of the present invention have found solutions to the above-discussed problems through the aerosol-generating substrate for the aerosol-generating article.
• a first aspect of the invention is accordingly to provide an aerosol-generating substrate for vaping, comprising semi-solid substrates, wherein up to about 1.0 wt. % of the total weight percentage of the aerosol-generating substrate are comprised of a carboxylic acid-containing alcohol solution, wherein one or more carboxylic acids are dissolved in the alcohol solution, wherein the semi-solid substrate is provided in form of a foam.
• a second aspect of the invention is accordingly to provide a method of preparing an aerosol-generating substrate for vaping, comprising a semi-solid substrate in form of a foam, comprising the steps of:
• an aerosol-generating substrate comprising one or more components selected from the list consisting of propylene glycol, 1, 3-Propanediol, glycerol and water;
• a third aspect of the invention is to provide an aerosol-generating substrate according to the present invention for use in reducing coughing fit from vaping.
• a fourth aspect of the invention is to provide an aerosol-generating substrate obtainable according to the present invention.
• the aerosol-generating substrate according to the present invention thanks to the small amount of carboxylic acids dissolved in an alcohol solution (wherein up to 1.0 wt.-% of the total weight percentage of the aerosol-generating substrate are comprised of the one or more carboxylic acids-containing alcohol solution), wherein the aerosol-generating substrate comprising semi-solid substrate provided in form of a foam or tobacco mousse), the aerosol-generating substrate according to the present invention unexpectedly reduces the coughing fit to an acceptable level. Moreover, it was found out also that the taste becomes smooth without any negative off taste. This effect of reducing coughing fit is particularly noticeable when one or more carboxylic acids such as stearic acid and/or decanoic acid are present in the alcohol solution of aerosol-generating substrate.
• the aerosol-generating substrate comprises between 0.2 wt. % and 1 wt. % of the carboxylic acid-containing alcohol solution based on the total weight percentage of the aerosol-generating substrate, preferably about 0.2 wt. %, 0.5 wt. %, 0.8 wt. %, or 1.0 wt. % of the carboxylic acid-containing alcohol solution in the total weight percentage of the aerosol-generating substrate.
• These ranges or amounts of the carboxylic acid present in the mixture are sufficient to reduce the irritation of throat/coughing fit to an acceptable level.
• the carboxylic acid-containing alcohol solution is provided in a concentration of between about 0.05 v/v % and about 0.2 v/v %, preferably between 0.08 v/v % and 0.15 v/v %, or more preferably at 0.1 v/v %.
• concentration used herein are provided in volume percent concentration for instance (v/v %), molarity or may be provided in mass percent concentration.
• the alcohol solution comprises only stearic acid and decanoic acid, preferably in the ratio of 10/90, 20/80, 30/70, 40/60, 50/50 of stearic acid/decanoic acid.
• the inventors have found out that these two compounds are particularly effective in suppressing throat irritations, wherein the ratios of 20/80 to 50/50 of stearic acid/decanoic acid are particularly effective in reducing coughing fit.
• the aerosol-generating substrate further comprises one or more components selected from the group consisting of propylene glycol, 1, 3 propanediol, glycerol, water, gum, flavourant, additives, nicotine, and binder.
• the solvent has a pH value in the range from 6 to 7, preferably 6.2 to 6.8, more preferably 6.3 to 6.5.
• acidic condition is preferred, for instance between 4 and 6.9.
• the carboxylic acid-containing alcohol solution can be prepared for instance by first weighing the weights of the ingredients (e.g. solvent, solute either in solid form or liquid form), mixing the mixture in a bottle, leaving the mixture for at least 24 hours in room temperature for the solute to completely dissolved in the solvent, and finally mixing the mixture before usage in foam making.
• the ingredients e.g. solvent, solute either in solid form or liquid form
• the mixture is heated at approximately 45° C. and/or aerated or mixed for approximately 5 minutes.
• the aerosol-generating substrate in form of foam can be prepared for instance by
• An aerosol-forming agent can be any compound, mixture and/or solution that is capable of forming an aerosol, e.g. when heated and/or in mixture with a tobacco-containing agent.
• Well known examples include humectants such as glycerin and propylene glycol, other alcohols, such as ethanol, etc.
• the term “semi-solid substrate” refers to the state of the substrate, which is highly viscous, slightly thicker than semi-fluid. In other words, the semi-solid substrate does not include solid material (i.e. firm and stable in shape) nor liquid or fluid.
• solid material i.e. firm and stable in shape
• liquid or fluid examples for “semi-solid substrates” in the present invention are for instance foam, gel, mousse, or thick mucus.
• the mousses formed as described herein are largely open-pored mousses because after cooling or heating of the aerosol-generating material, vapour is released from the mousse, substantially all of the humectant appears to be released based on measuring of the weight of the mousse portion before and after heating, which could not be readily explained if the humectant was not able to travel through neighboring pores to reach the surface of the mousse portion.
• alternative explanations cannot be totally excluded—for example closed pores could perhaps be opened by rupturing a closed cell wall as a result of the pressure of vaporized gas, etc.
• aeration values indicate the vol. % of the foam or mousse which is composed of air.
• the actual aeration values of samples have been estimated using the following procedure: a sample of “foam” is made without taking any action (e.g. whipping or aerating with an aeration machine) to aerate the “foam” and a known volume of this unfoamed “foam”/material is measured. Then a sample of the foam made after performing an aeration step (e.g. a step such as whipping or aerating with an aeration machine) and the same known volume of the aerated foam is again weighed and the percentage reduction in the weight is calculated.
• an aeration step e.g. a step such as whipping or aerating with an aeration machine
• the (dynamic) viscosity described herein refers to the flow behaviour of liquids. It is defined as the internal frictional resistance of a liquid to the application of a pressure or a shearing stress.
• the dynamic viscosity is given in millipascal-seconds (mPas) and is determined by using a rotary viscometer. The viscosity measured in performed at room temperature i.e. 22° C.
• aeration is to be understood as introduction of air or gasses into, through an external step, into the material.
• the aeration can be performed for instance though whipping, beating, mixing, or aerating with an aeration machine such as Krups Prep & Cook HP 5031 mousse whipping shuffle, or by injection air with an aerator, e.g. like Mondomix aerator.
• Aeration can be carried out at any suitable temperature.
• the duration of the aeration can be for instance 1, 2, 3, 4, 5 or 10 minutes or more.
• Another class of suitable foam stabilizing agents are hydroxyalkylated carbohydrates, and more preferably cellulose ethers and derivatives thereof.
• a cellulose ether or derivative thereof that can be used can have at least one substituent selected from the group consisting of methyl, ethyl, hydroxyethyl and hydroxypropyl groups. It can further be substituted with a linear or branched substituted or unsubstituted alkyl radicals having 1-20 carbon atoms or an aralkyl radical having 7 to 20 carbon atoms. Such radical is preferably attached by an ether linkage.
• Suitable substituents can e.g.
• foam-forming agent may be additionally added to the mixture of aerosol-generating substrate.
• the foam-forming agent is not particularly restricted.
• the foam-forming agent of the present foam is selected from the group consisting of agar, gellan gum, lecithin, polyglycerol esters of fatty acids, glycerol esters of fatty acids, sorbitan esters of fatty acids, and/or mixtures thereof, without being limited thereto.
• a preferred foam-forming agent is gellan gum.
• Glycerol esters can be prepared by standard esterification methods.
• the foam-forming agent can suitably be a compound such as glycerol monostearate and/or glycerol monooleate.
• Polyglycerol esters can be prepared by polymerizing glycerin under alkaline conditions suitably followed by reacting them with specific fatty acids. Suitable polyglycerol esters can be hexaglycerol monooleate, octaglycerol monostearate and/or octaglycerol monooleate.
• Sorbitan esters of fatty acids used in certain embodiments of the present invention can be sorbitan monostearate, sorbitan monooleate and/or sorbitan mono palmitate. Furthermore, any possible combinations of compounds belonging to the above-mentioned classes can be used.
• the present methods can be realized also through by having a step of mixing the aerosol-generating substrate that is aerated after adding of the foam-stabilizing agent and/or after cooling of the mixture. This does not exclude that other aeration steps are also being carried out, and according to certain embodiments, one, two or preferably all of the optional aeration steps are carried out in the present methods. Also, it is not excluded that aeration is carried out already concomitantly with a mixing and/or addition step.
• the method of aeration is not particularly restricted and can involve e.g. an injection of air, a whipping in of air—e.g. a mixing with a sufficiently large paddle/shuffle and/or a sufficient paddle movement and/or at sufficient lower speed so that air can be introduced into the mixture, bubbling air through the mixture, etc.
• aeration can be carried out using a sufficient mixing machine similar to a mixer for preparing a mousse, e.g. a Krups Prep & Cook HP 5031 mousse whipping shuffle, and or by injection air with an aerator, e.g. like Mondomix aerator.
• Aeration can be carried out at a suitable temperature, e.g.
• aeration is carried out concomitantly with a mixing and/or in a step of adding an ingredient, e.g. when using whipping.
• the aerosol-generating substrate as claimed presently even without adding additionally foam-forming agent and/or foam-stabilizing agent, with the above-explained method, the mixture of aerosol-generating substrate can be transformed into semi-solid condition i.e. foam, mousse, gel or the like.
• the aerosol-generating substrate of the present invention is a semi-solid substrate.
• ingredients for forming the aerosol-generating foam such as the aerosol-forming agent, the form-foaming agent, the foam-stabilizing agent, the tobacco-containing agent, the inhalable agent, the at least one non-tobacco flavoring agent and the solvent are not particularly restricted.
• a gas used for aeration is not particularly restricted, and can be e.g. air.
• further components can be admixed. According to certain embodiments, essentially no further components or no further components are admixed, though.
• the aerosol-forming agent can further comprise water. According to certain embodiments, no water is contained, though, since water in aerosol form can burn the mouth of a user. Water can be contained in an amount of 0-15 wt.-% of the total weight percentage of the foam or the aerosol-generating substrate, e.g. 5-10 wt.-%.
• Tobacco mousse containing different percentages of carboxylic acid-containing alcohol solution.
• Tobacco Mousse Sample 1 Sample 2
• Sample 3 Sample 4
• Sample 5 Propylene glycol 24 wt. % 24 wt. % 24 wt. % 24 wt. % 24 wt. % Glycerin (G) 36 wt.-% 36 wt.-% 36 wt.-% 36 wt.-% 36 wt.-% Stearic acid- and 0 wt.- % 0.2 wt. % 0.5 wt. % 0.8 wt. % 1.0 wt.
• Table 1 shows tobacco mousse (foam) comprising different weight percentages of carboxylic acids (i.e. stearic acid and decanoic acid)-containing alcohol solution were investigated.
• carboxylic acids i.e. stearic acid and decanoic acid
• Table 1 shows tobacco mousse (foam) comprising different weight percentages of carboxylic acids (i.e. stearic acid and decanoic acid)-containing alcohol solution were investigated.
• carboxylic acids i.e. stearic acid and decanoic acid
• stearic acid and decanoic acid have been used in all the samples, where these carboxylic acids are dissolved in an alcohol solution. It is believed that due to their chemical similarity, both stearic acid and decanoic acid can be used interchangeably or replaceable.
• the carboxylic acid-containing alcohol solution has a concentration of 0.1%.
• the propylene glycol, the glycerin, carboxylic acid alcohol solution comprising an equal amount of stearic acid and decanoic acid
• the purified water were whipped and aerated for 5-10 min, preferably at 6 min, at 45° C. using a Krups Prep & Cook HP5031 mousse whipping shuffle.
• whipping up the mousse the speed has to be adjusted so that the volume visibly increases, and small bubbles appear and partly stay in the foam. If whipping is too fast then mixing will take over and the foamy structure is going to collapse, thus back to fluid.
• whipping is started slowly and the whipping speed is slowly increased as the foam begins to develop a lighter, more mousse-like texture; the speed is backed-off by about 10% if it is noticed that the mousse seems to be reducing its mousse-like texture and becoming seemingly less aerated.
• a sudden cooling with ice or cool water is recommendable.
• Krups device the best results can be obtained with a speed in between 60 and 200 rpm. Adaptation is within the skilled person's knowledge in accordance with the above description.
• a next step (within 1 minute of the previous step), the gum was added, and the mixture was whipped and aerated for 5-10 minutes, preferably at 6 min, at 45° C. using a Krups Prep & Cook HP5031 mousse whipping shuffle. Afterwards the tobacco powder was added and whipping, and aeration were carried out for 5-10 min, preferably at 6 min, at 45° C. with the same method. Next, the binder was added, and the mixture was again whipped and aerated for 5-10 min, preferably at 6 min, at 45° C. with the same method. Finally, the mixture was placed in an oven at 50° C. for 12 hours before is ready to be packed and be used.
• the Sample 1 (containing no carboxylic acid in the consumables) were first given to the test subjects to be rated. Each test subject inhaled 10 puffs within 3 minutes and the degrees of the throat irritation were rated (Score of 100 being very irritated; Score of 60 being rather irritated; Score of 30 being slightly irritated; Score of 0 being not irritated). After Sample 1 being rated, Samples 2, 3, 4 and 5 were given in a random order to the test subjects. The procedure was repeated similar as in the control sample (Sample 1). The coughing fit scores were rated by the test subjects based on their sensation to throat irritation. A pause of 60 seconds (or 120 seconds) is given before a new sample is given to the test subject.
• the Samples 2, 3, 4 and 5 which comprised of 0.2 wt.-%, 0.5 wt.-%, 0.8 wt.-% and 1.0 wt.-% of carboxylic acid-containing alcohol solution, respectively, in the total weight percentage mixture of aerosol-generating substrate showed lower mean coughing fit scores compared to the control sample (Sample 1).
• the total weight of Sample 1 (0 wt. % Stearic acid and decanoic acid) is 500 g.
• Sample 1 (control sample) which did not comprise any carboxylic acid (fatty acid) registered highest mean coughing fit score (71.25). It was observed that aerosol-generating substrates comprising 0.2 wt. % and 1.0 wt. % of carboxylic acid-containing alcohol solution based on the total weight percentage of the aerosol-generating substrates have significantly low scores i.e. less than 40 compared to the control Sample 1, namely 36.25, 33, 39 and 37 for Samples 2, 3, 4 and 5, respectively. These values represent only slightly throat irritation or coughing fit in the Samples 2 to 5 were observed as reported by various test subjects.
• the lowest amount of the carboxylic acid-containing alcohol contains in the aerosol-generating substrate performed in the experiment was 0.2 wt. % based on the total weight percentage of the aerosol-generating substrate, it is believe that lower amount such as 0.1 wt. % or 0.05 wt. % based on the total weight percentage of the aerosol-generating substrate would be equally effective in suppressing throat irritation or is has a reduced coughing fit.
• the tobacco ingredient containing agent and/or the inhalable agent is configured in such a way that it is released upon heating together with the aerosol-forming agent by only being essentially adsorbed to and/or absorbed in the foam structure.
• a mass loss in the foam can be observed that shows that essentially at least the mass of the foam-forming agent and the foam-stabilizing agent remains.
• the structure of the foam is mainly formed by the foam-forming agent, which forms a “capsulation” for adhering and/or absorbing the aerosol forming agent and the tobacco ingredient containing agent and/or an inhalable agent, whereas the foam-stabilizing agent stabilizes the foam to keep the foam form.

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• Chemical & Material Sciences (AREA)
• Chemical Kinetics & Catalysis (AREA)
• General Chemical & Material Sciences (AREA)
• Health & Medical Sciences (AREA)
• General Health & Medical Sciences (AREA)
• Toxicology (AREA)
• Life Sciences & Earth Sciences (AREA)
• Agronomy & Crop Science (AREA)
• Botany (AREA)
• Medicinal Preparation (AREA)
• Manufacture Of Tobacco Products (AREA)
• Cosmetics (AREA)

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• 2021
  • 2021-02-25 KR KR1020227028376A patent/KR20220146449A/ko active Search and Examination
  • 2021-02-25 US US17/801,346 patent/US20230082862A1/en active Pending
  • 2021-02-25 JP JP2022551013A patent/JP2023515553A/ja active Pending
  • 2021-02-25 EP EP21707678.5A patent/EP4110095A1/en active Pending
  • 2021-02-25 WO PCT/EP2021/054652 patent/WO2021170703A1/en unknown

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