US20170326062A1 - Compositions for skin application - Google Patents
Compositions for skin application Download PDFInfo
- Publication number
- US20170326062A1 US20170326062A1 US15/593,509 US201715593509A US2017326062A1 US 20170326062 A1 US20170326062 A1 US 20170326062A1 US 201715593509 A US201715593509 A US 201715593509A US 2017326062 A1 US2017326062 A1 US 2017326062A1
- Authority
- US
- United States
- Prior art keywords
- skin
- composition
- skin care
- carnosine
- silybin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 76
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims abstract description 34
- 239000000126 substance Substances 0.000 claims abstract description 33
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 claims abstract description 19
- 108010087806 Carnosine Proteins 0.000 claims abstract description 19
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229940044199 carnosine Drugs 0.000 claims abstract description 19
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 claims abstract description 19
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 claims abstract description 19
- FDQAOULAVFHKBX-UHFFFAOYSA-N Isosilybin A Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC(=CC=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 FDQAOULAVFHKBX-UHFFFAOYSA-N 0.000 claims abstract description 18
- SEBFKMXJBCUCAI-UHFFFAOYSA-N NSC 227190 Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 claims abstract description 18
- VLGROHBNWZUINI-UHFFFAOYSA-N Silybin Natural products COc1cc(ccc1O)C2OC3C=C(C=CC3OC2CO)C4Oc5cc(O)cc(O)c5C(=O)C4O VLGROHBNWZUINI-UHFFFAOYSA-N 0.000 claims abstract description 18
- 229940043175 silybin Drugs 0.000 claims abstract description 18
- 235000014899 silybin Nutrition 0.000 claims abstract description 18
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims abstract description 17
- 229960005305 adenosine Drugs 0.000 claims abstract description 17
- 241000589596 Thermus Species 0.000 claims abstract description 16
- 239000008365 aqueous carrier Substances 0.000 claims abstract description 7
- -1 sufactants Substances 0.000 claims description 9
- 239000004909 Moisturizer Substances 0.000 claims description 6
- 239000003995 emulsifying agent Substances 0.000 claims description 6
- 239000003906 humectant Substances 0.000 claims description 6
- 239000000314 lubricant Substances 0.000 claims description 6
- 230000001333 moisturizer Effects 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 6
- 239000002270 dispersing agent Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 12
- 230000003712 anti-aging effect Effects 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 4
- 238000012360 testing method Methods 0.000 description 37
- 210000003491 skin Anatomy 0.000 description 29
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 13
- XPDXVDYUQZHFPV-UHFFFAOYSA-N Dansyl Chloride Chemical compound C1=CC=C2C(N(C)C)=CC=CC2=C1S(Cl)(=O)=O XPDXVDYUQZHFPV-UHFFFAOYSA-N 0.000 description 10
- 238000002156 mixing Methods 0.000 description 10
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
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- 244000068988 Glycine max Species 0.000 description 6
- 235000010469 Glycine max Nutrition 0.000 description 6
- 230000003822 cell turnover Effects 0.000 description 6
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 5
- BDOYKFSQFYNPKF-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;sodium Chemical compound [Na].[Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O BDOYKFSQFYNPKF-UHFFFAOYSA-N 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 4
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 4
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- 210000004209 hair Anatomy 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
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- 238000010186 staining Methods 0.000 description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 3
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 3
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- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 description 3
- 230000008033 biological extinction Effects 0.000 description 3
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 3
- 229940075529 glyceryl stearate Drugs 0.000 description 3
- 238000000265 homogenisation Methods 0.000 description 3
- 239000000787 lecithin Substances 0.000 description 3
- 235000010445 lecithin Nutrition 0.000 description 3
- 229940067606 lecithin Drugs 0.000 description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 239000004302 potassium sorbate Substances 0.000 description 3
- 235000010241 potassium sorbate Nutrition 0.000 description 3
- 229940069338 potassium sorbate Drugs 0.000 description 3
- RMGVATURDVPNOZ-UHFFFAOYSA-M potassium;hexadecyl hydrogen phosphate Chemical compound [K+].CCCCCCCCCCCCCCCCOP(O)([O-])=O RMGVATURDVPNOZ-UHFFFAOYSA-M 0.000 description 3
- 230000000475 sunscreen effect Effects 0.000 description 3
- 239000000516 sunscreening agent Substances 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 description 2
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 description 2
- WSSJONWNBBTCMG-UHFFFAOYSA-N 2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester Chemical compound C1C(C)(C)CC(C)CC1OC(=O)C1=CC=CC=C1O WSSJONWNBBTCMG-UHFFFAOYSA-N 0.000 description 2
- RMTFNDVZYPHUEF-XZBKPIIZSA-N 3-O-methyl-D-glucose Chemical compound O=C[C@H](O)[C@@H](OC)[C@H](O)[C@H](O)CO RMTFNDVZYPHUEF-XZBKPIIZSA-N 0.000 description 2
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 2
- CYGIJEJDYJOUAN-UHFFFAOYSA-N Isosilychristin Natural products C1=C(O)C(OC)=CC(C2C3C=C(C4C(C3=O)(O)OCC42)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 CYGIJEJDYJOUAN-UHFFFAOYSA-N 0.000 description 2
- 244000292697 Polygonum aviculare Species 0.000 description 2
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- 241000320380 Silybum Species 0.000 description 2
- 235000010841 Silybum marianum Nutrition 0.000 description 2
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 2
- 241000589499 Thermus thermophilus Species 0.000 description 2
- 229960005193 avobenzone Drugs 0.000 description 2
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 description 2
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- 229920006037 cross link polymer Polymers 0.000 description 2
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 2
- PKPOVTYZGGYDIJ-UHFFFAOYSA-N dioctyl carbonate Chemical compound CCCCCCCCOC(=O)OCCCCCCCC PKPOVTYZGGYDIJ-UHFFFAOYSA-N 0.000 description 2
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- KHIQYZGEUSTKSB-UHFFFAOYSA-L disodium;4-dodecoxy-4-oxo-3-sulfobutanoate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O.CCCCCCCCCCCCOC(=O)C(S(O)(=O)=O)CC([O-])=O KHIQYZGEUSTKSB-UHFFFAOYSA-L 0.000 description 2
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- 238000010438 heat treatment Methods 0.000 description 1
- UQEAIHBTYFGYIE-UHFFFAOYSA-N hexamethyldisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)C UQEAIHBTYFGYIE-UHFFFAOYSA-N 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 229960003921 octisalate Drugs 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 229940093916 potassium phosphate Drugs 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- BMLIIPOXVWESJG-LMBCONBSSA-N silychristin Chemical compound C1=C(O)C(OC)=CC([C@H]2[C@@H](C3=C(C(=CC(=C3)[C@@H]3[C@H](C(=O)C4=C(O)C=C(O)C=C4O3)O)O)O2)CO)=C1 BMLIIPOXVWESJG-LMBCONBSSA-N 0.000 description 1
- BMLIIPOXVWESJG-UHFFFAOYSA-N silychristin A Natural products C1=C(O)C(OC)=CC(C2C(C3=C(C(=CC(=C3)C3C(C(=O)C4=C(O)C=C(O)C=C4O3)O)O)O2)CO)=C1 BMLIIPOXVWESJG-UHFFFAOYSA-N 0.000 description 1
- CYGIJEJDYJOUAN-JSGXPVSSSA-N silydianin Chemical compound C1=C(O)C(OC)=CC([C@H]2[C@H]3C=C([C@@H]4[C@@](C3=O)(O)OC[C@@H]42)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 CYGIJEJDYJOUAN-JSGXPVSSSA-N 0.000 description 1
- 235000017700 silymarin Nutrition 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 230000036560 skin regeneration Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 description 1
- CIAZJIQGPOGZDS-UHFFFAOYSA-N trimethyl-(methyl-tetradecyl-trimethylsilyloxysilyl)oxysilane Chemical compound CCCCCCCCCCCCCC[Si](C)(O[Si](C)(C)C)O[Si](C)(C)C CIAZJIQGPOGZDS-UHFFFAOYSA-N 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Definitions
- the present invention relates to the fields of skin care compositions, more specifically to preparations for application to the skin.
- compositions exist for application to the skin for various purposes including providing a sunscreen, softening, moisturizing, exfoliating, wrinkle removal, scar removal, repairing damage, anti-aging, or treating infection.
- the compositions described herein provide improved anti-aging and repair effects for skin.
- a skin care composition comprising thermus thermophiles ferment and silybin.
- the skin care composition comprises: from about 0.5 to about 5 percent by weight (wt %), of thermus thermophiles ferment, and from about 0.05 to about 0.5 wt % of silybin, all weight percents based on the total weight of the composition.
- skin care composition further comprises one or more additional substances selected from carnosine, adenosine and CG-EDP3.
- the skin care composition comprises: from 0 to about 0.5 wt % of carnosine, from 0 to about 0.1 wt % of adenosine, and from 0 to about 0.00015 of CG-EDP3, all weight percents based on the total weight of the composition.
- the skin care composition further comprises one or more substances selected from emulsifiers, humectants, lubricants, sufactants, dispersants, preservatives, moisturizers.
- the skin care composition further comprises a carrier.
- the carrier may be an aqueous carrier.
- the skin care compositions contemplated herein comprise the substances thermus thermophiles ferment and silybin.
- the compositions contemplated and described herein further comprise one or more additional substances selected from carnosine, adenosine and CG-EDP3.
- the substances are dispersed in an aqueous carrier, such as water, to be applied to the skin in a spreadable form.
- the compositions comprising these substances provide anti-aging and reparative effects for skin.
- compositions contemplated herein may further comprise any one or more of various emulsifiers, humectants, lubricants, sufactants, dispersants, preservatives, moisturizers, and other substances that will impart the desired functional and aesthetic properties to the compositions.
- Thermus thermophiles ferment is a substance described in detail in US Patent Application Publication No. 2004/0115766, which incorporated herein by reference. More particularly, thermus thermophiles ferment is a mixture of proteins obtained by fermentation of micro-organisms of the family Thermus, which can be found adjacent hydrothermal sources in deep marine environments. Thermus thermophiles ferment is commercially available, for example without limitation, under the tradename VENUCEANETM from Sederma of Edison, N.J., U.S.A. or Le Perray en Yvelines cedex, France. It is believed that Thermus thermophiles ferment has a detoxifying and anti-radical effect and is useful for preventing and/or treating damage to skin associated with infrared radiation, such as spots, wrinkles and dryness resulting from exposure to sunlight.
- Silybin is a plant lignin, i.e., a major flavonolignan, obtained from seeds of Silybum marianum , which is also known as the Mediterranean milk thistle.
- Silybin is commercially available from Puredia Corporation Ltd of Kowloon, Hong Kong.
- Silybin is also commercially available from Indena USA, Inc. of Seattle, Wash., USA.
- Silybin is also commercially available from Provital, S.A. of Barcelona, Spain, as well as from Orient Stars LLC of Carson, Calif., USA.
- silybin and its related silymarins also known as flavonolignins (e.g., silybum, silybinin, silydianin, silychristin, siosilybin) may be useful as cross-linking, anti-inflammatory, anti-wrinkle, moisturizing agents, as well as promoting collagen production in the skin and resisting ultraviolet injury to the skin.
- flavonolignins e.g., silybum, silybinin, silydianin, silychristin, siosilybin
- Carnosine is a dipeptide of the amino acids beta-alanine and histidine and is found primarily in muscle and brain tissues. Carnosine is commercially available from Kumar Organic Products Ltd. Of Bangalore, India. Carnosine is also commercially available from Symrise of Teterboro, N.J., USA. Carnosine is also commercially available from Orient Stars LLC of Carson, Calif., USA. It is believed that carnosine is useful for skin whitening and moisturizing, as well as freckle reduction.
- Adenosine is a purine nulcleoside comprising a molecule of adenine attached to a ribose sugar molecule moiety.
- Adenosine is commercially available from Orient Stars LLC of Carson, Calif., USA.
- Adenosine is also commercially available from Spectrum Manufacturing of New Brunswick, N.J., USA.
- Adenosine is believed to be an anti-aging and anti-oxidation agent for skin.
- CG-EDP3 generally comprises a blend of disodium ethylenediaminetetraacetic acid (EDTA), glycerin, glycine soja (soybean) oil, hydrogenated lecithin, oligopeptide-24, phenoxyethanol, and sodium oleate in water.
- EDTA disodium ethylenediaminetetraacetic acid
- glycerin glycerin
- glycine soja (soybean) oil hydrogenated lecithin
- oligopeptide-24 oligopeptide-24
- phenoxyethanol phenoxyethanol
- sodium oleate sodium oleate in water.
- CG-EDP3 is a tradename and is commercially from Caregen of Gunpo-si, South Korea. It is believed that CG-EDP3 is useful for regeneration of damaged skin and providing anti-aging effects.
- skin care compositions according to the embodiments contemplated herein comprise the aforesaid substances in the amounts provided in Table 1 below.
- thermus thermophiles ferment is included in the composition in an amount of from about 0.5 to about 5 percent (%), by weight, based on the total weight of the composition.
- the composition comprises from about 1 to about 3% of thermus thermophiles ferment, or from about 1 to about 2, or from about 1.4 to about 1.6%, by weight, based on the total weight of the composition.
- the silybin is included in the composition in an amount of from about 0.05 to about 0.5%, by weight, based on the total weight of the composition.
- the composition comprises from about 0.1 to about 0.3% of silybin, or from about 0.1 to about 0.2, or from about 0.10 to about 0.15%, by weight, based on the total weight of the composition.
- compositions contemplated herein may, optionally, further comprise from 0 to about 0.5% of carnosine, by weight, based on the total weight of the composition.
- the composition comprises from about 0.01 to about 0.5% of carnosine, or from about 0.05 to about 0.4%, or from about 0.1 to about 0.3%, by weight, based on the total weight of the composition.
- compositions contemplated herein may, optionally, further comprise from 0 to about 0.1% of adenosine, by weight, based on the total weight of the composition.
- the composition comprises from about 0.01 to about 0.08% of adenosine, or from about 0.02 to about 0.7%, or from about 0.03 to about 0.05%, by weight, based on the total weight of the composition.
- compositions contemplated herein may, optionally, further comprise from 0 to about 0.00015% of CG-EDP3, by weight, based on the total weight of the composition.
- the composition comprises from about 0.00005 to about 0.00015% of CG-EDP3, or from about 0.000075 to about 0.000125%, or from about 0.0001 to about 0.000125%, by weight, based on the total weight of the composition.
- compositions contemplated herein may further comprise a carrier which may be aqueous or non-aqueous.
- a carrier which may be aqueous or non-aqueous.
- an aqueous carrier comprises for example, without limitation, from about 30 to about 100% of water, by weight, based on the total weight of the carrier.
- a non-aqueous carrier may, for example without limitation, comprise from about 30 to about 100% of an organic liquid or gel, such as glycerol or another alcohol.
- the substances are dispersed in the carrier to be applied to the skin in a spreadable form (e.g., a lotion, gel or cream).
- other substances are added to the skincare composition to improve its aesthetic qualities or promote skin health or healing.
- carriers, emulsifiers, humectants, lubricants, surfactants, thickeners, preservatives, moisturizers, and other additives may be included in the composition with one or more of the substances discussed hereinabove (i.e., thermus thermophiles ferment, silybin, carnosine, adenosine and CG-EDP3).
- Suitable emulsifiers include, without limitation, sorbitan monostearate, lecithin, and potassium phosphate.
- Suitable humectants include, without limitation, propylene glycol, propandiol, and glycerin.
- Suitable lubricants include, without limitation, glycerin, dimethicone and glyceryl oleate.
- Suitable surfactants include, without limitation, polyethylene glycol-100 stearate, glyceryl stearate, and potassium cetyl phosphate.
- Suitable thickeners include, without limitation, C 12 -C 15 alkyl benzoate, carbomer and xantham gum.
- Suitable preservatives include, without limitation, potassium sorbate, phenoxyethanol, and chlorphenisin.
- Suitable moisturizers include, without limitation, dimethicone, caprylic or capric triglyceride, and capryl methicone.
- compositions contemplated and described herein are useful for many purposes relating to skin care and repair, including without limitation, sunscreen, softening, moisturizing, exfoliating, wrinkle removal, scar removal, repairing damage, anti-aging, or treating infection.
- Test Product for application to the skin as a sunscreen, containing the substances listed in Table 2 below, will now be described.
- Phase A1 substance acrylates/C 10-30 alkyl acrylate crosspolymer, #12
- Phase A2 substances are added to the tank: dipotassium glycyrrhizate (#19), adenosine (#13), disodium ethylenediaminetetraacetic acid (EDTA) (#20a), panthenol (#31), and PEG/PPG -17/6 copolymer (#5).
- Mixing is continued for 20 to 30 minutes, adjusting mixer speed as mixture thickens, until fully hydrated and uniform with no fish eyes. Heating to 80° C.-82° C. is commenced and mixing continues for 10 to 15 minutes until the mixture is uniform.
- the main tank with Premix A is covered and set aside.
- a small portion of water (#1) and all of the Phase B substances, silybin (#40), lecithin (#29) and dipropylene glycol (#3), are added to a stockpot and heated to 60° C.-65° C. while stirring with a mixer, for 5 to 10 minutes until uniform.
- the stockpot with Premix B is covered and set aside.
- Phase C substances include: glyceryl stearate (#8), polyethylene glycol-100 stearate (#9), methyl glucose sesquistearate (#10), cetyl alcohol (#18), homosalate (#47), octocrylene (#50), butyl methoxydibenzoylmethane (#49), ethylhexyl salicylate (#48), disodium EDTA (#20b), dicaprylyl carbonate (#4), tocopheryl acetate (#46), polyethylene glycol dimethicone (#32) and caprylyl methicone (#2).
- the Phase C mixture is heated to 80° C.-82° C. while mixing on slow to medium mixing speed for 5 to 10 minutes, until uniform.
- the tank with Premix C is covered and set
- a small portion of water (#1) and the Group H substance, carnosine (#17) are added to a stockpot and stirred for 5-10 minutes until completely dispersed.
- the stockpot with Phase H mixture is covered and set aside.
- the Premix A is added to a main tank, heated to 80° C.-82° C. and mixed. Then the
- Phase A3 substances hydrogenated palm glycerides (#27) and potassium cetyl phosphate (#6), are added to the tank and mixed for 10 to 15 minutes until uniform.
- the Phase A mixture is cooled to 73° C.-75° C., while Premix B is reheated to 60° C.-65° C., if necessary.
- Premix B is added to Premix A in the main tank, while continuing to mix for another 5 to 10 minutes until uniform.
- the main tank and its contents are held at 73° C.-75° C.
- Premix C is reheated to 80° C.-82° C., if necessary, and then added to the main tank, while stirring continues.
- Premixes A, B and C The contents of the main tank (i.e., Premixes A, B and C) are homogenized for 5 to 8 minutes. Premix D is then added to the main tank while homogenation mixing continues for another 3 to 5 minutes.
- the Phase E substances are then added to the main tank while homogenation mixing continues for another 3 to 5 minutes.
- the Phase E substances include C 11-15 Pareth-40 (#14), C 11-15 Pareth-7 (#15), caprylyl glycol (#16), disodium lauryl sulfosuccinate (#21), phenoxyethanol (#33a), polyacrylate-15 (#34), polyacrylate-17 (#35), and sodium laureth-12 sulfate (#43).
- the Phase F substances are premixed with one another.
- the Phase F substances include: isohexadecane (#28), polysorbate 80 (#37), sodium acrylate/sodium acryloyldimethyl taurate copolymer (#41), and sorbitan oleate (#45).
- the Phase F premix is added to the main tank and the mixture homogenized for 5 to 8 minutes.
- the main tank and its contents are cooled to 43° C.-45° C. and then, with continued stirring, the Group G substances were added: caprylyl glycol (#16), hexylene glycol (#25), phenoxyethanol (#33b), potassium sorbate (#39), SD Alcohol 40-B (#11), glycerin (#23), polygonum aviculare extract (#36), sodium benzoate (#42), Thermus thermophilus ferment (#7), oligopeptide-24 (#30), glycine soja (soybean) oil (#24), and sodium oleate (#44).
- Premix H (containing carnosine) is added to the main tank next, followed by the Phase I substance, Warm Sandalwood (#34), while stirring continues.
- the contents of the main tank are mixed for another 15 to 20 minutes until uniform and then cooled to 28° C.-30° C. Upon reaching the cooled temperature, the mixing is ceased.
- skin cell turnover i.e., exfoliation
- Dansyl chloride a fluorescent blue- or blue-green substance was used at the untreated and treated skin sites to provide a means for measuring cell turnover at those sites.
- the dye fades as skin cells are lost from the surface of the skin during cell turnover. The faster the dye fades, the faster the cell turnover is occurring, and the faster skin regeneration is occurring.
- test subjects 35 human test subjects were initially enlisted for this study and randomly assigned a subject number of 1-35. There were 9 males, 26 females and a mix of ethnicities. 34 of the test subjects successfully completed the study. One test subject dropped out of the study for reasons unrelated to the study.
- test subjects All evenly numbered test subjects also had dansyl chloride applied to a test site on their upper left arm. All oddly-numbered test subjects had dansyl chloride applied to a test site on their upper right arm.
- the Test Product was applied to the test site on each test subject, in 0.2 gram amounts. More particularly, each enrolled human subject had the Test Product applied by a trained clinical technician every weekday morning using a finger cot. The test subjects each applied the Test Product to the test site at home in the evening using a finger cot. There was no Test Product application on Saturday or Sunday. The volume of Test Product applied to the test site was sufficient to cover the area when rubbed in with the finger using a finger cot for approximately 10 scrubs.
- Each enrolled test subject was provided with instructions on washing of the test site. Washing of the test sites during the course of the study was done using Ivory Soap® provided by the testing facility.
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- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
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Abstract
Skin care compositions are provided which contain thermus thermophiles ferment and silybin and provide anti-aging and reparative effect for skin. The compositions may also include one or more additional substances selected from carnosine, adenosine and CG-EDP3. The substances are dispersed in an aqueous carrier, such as water, to be applied to the skin in a spreadable form.
Description
- The present invention claims priority from U.S. provisional patent application Ser. No. 62/335,918, filed May 13, 2016, which is hereby incorporated herein by reference in its entirety.
- The present invention relates to the fields of skin care compositions, more specifically to preparations for application to the skin.
- Many compositions exist for application to the skin for various purposes including providing a sunscreen, softening, moisturizing, exfoliating, wrinkle removal, scar removal, repairing damage, anti-aging, or treating infection. The compositions described herein provide improved anti-aging and repair effects for skin.
- A skin care composition is provided comprising thermus thermophiles ferment and silybin. In some embodiments, the skin care composition comprises: from about 0.5 to about 5 percent by weight (wt %), of thermus thermophiles ferment, and from about 0.05 to about 0.5 wt % of silybin, all weight percents based on the total weight of the composition.
- In some embodiments, skin care composition further comprises one or more additional substances selected from carnosine, adenosine and CG-EDP3. In some embodiments, the skin care composition comprises: from 0 to about 0.5 wt % of carnosine, from 0 to about 0.1 wt % of adenosine, and from 0 to about 0.00015 of CG-EDP3, all weight percents based on the total weight of the composition.
- In some embodiments, the skin care composition further comprises one or more substances selected from emulsifiers, humectants, lubricants, sufactants, dispersants, preservatives, moisturizers.
- In some embodiments, the skin care composition further comprises a carrier. The carrier may be an aqueous carrier.
- The skin care compositions contemplated herein comprise the substances thermus thermophiles ferment and silybin. Optionally, the compositions contemplated and described herein further comprise one or more additional substances selected from carnosine, adenosine and CG-EDP3. The substances are dispersed in an aqueous carrier, such as water, to be applied to the skin in a spreadable form. The compositions comprising these substances provide anti-aging and reparative effects for skin. As is typical for compositions applicable to the skin, the compositions contemplated herein may further comprise any one or more of various emulsifiers, humectants, lubricants, sufactants, dispersants, preservatives, moisturizers, and other substances that will impart the desired functional and aesthetic properties to the compositions.
- Thermus thermophiles ferment is a substance described in detail in US Patent Application Publication No. 2004/0115766, which incorporated herein by reference. More particularly, thermus thermophiles ferment is a mixture of proteins obtained by fermentation of micro-organisms of the family Thermus, which can be found adjacent hydrothermal sources in deep marine environments. Thermus thermophiles ferment is commercially available, for example without limitation, under the tradename VENUCEANE™ from Sederma of Edison, N.J., U.S.A. or Le Perray en Yvelines cedex, France. It is believed that Thermus thermophiles ferment has a detoxifying and anti-radical effect and is useful for preventing and/or treating damage to skin associated with infrared radiation, such as spots, wrinkles and dryness resulting from exposure to sunlight.
- Silybin is a plant lignin, i.e., a major flavonolignan, obtained from seeds of Silybum marianum, which is also known as the Mediterranean milk thistle. Silybin is commercially available from Puredia Corporation Ltd of Kowloon, Hong Kong. Silybin is also commercially available from Indena USA, Inc. of Seattle, Wash., USA. Silybin is also commercially available from Provital, S.A. of Barcelona, Spain, as well as from Orient Stars LLC of Carson, Calif., USA. It is believed that silybin and its related silymarins, also known as flavonolignins (e.g., silybum, silybinin, silydianin, silychristin, siosilybin), may be useful as cross-linking, anti-inflammatory, anti-wrinkle, moisturizing agents, as well as promoting collagen production in the skin and resisting ultraviolet injury to the skin.
- Carnosine is a dipeptide of the amino acids beta-alanine and histidine and is found primarily in muscle and brain tissues. Carnosine is commercially available from Kumar Organic Products Ltd. Of Bangalore, India. Carnosine is also commercially available from Symrise of Teterboro, N.J., USA. Carnosine is also commercially available from Orient Stars LLC of Carson, Calif., USA. It is believed that carnosine is useful for skin whitening and moisturizing, as well as freckle reduction.
- Adenosine is a purine nulcleoside comprising a molecule of adenine attached to a ribose sugar molecule moiety. Adenosine is commercially available from Orient Stars LLC of Carson, Calif., USA. Adenosine is also commercially available from Spectrum Manufacturing of New Brunswick, N.J., USA. Adenosine is believed to be an anti-aging and anti-oxidation agent for skin.
- CG-EDP3 generally comprises a blend of disodium ethylenediaminetetraacetic acid (EDTA), glycerin, glycine soja (soybean) oil, hydrogenated lecithin, oligopeptide-24, phenoxyethanol, and sodium oleate in water. CG-EDP3 is a tradename and is commercially from Caregen of Gunpo-si, South Korea. It is believed that CG-EDP3 is useful for regeneration of damaged skin and providing anti-aging effects.
- More particularly, skin care compositions according to the embodiments contemplated herein comprise the aforesaid substances in the amounts provided in Table 1 below.
-
TABLE 1 Compound % by Weight thermus thermophiles ferment 0.5-5 silybin 0.05-0.5 carnosine 0-0.5 adenosine 0-0.1 CG-EDP3 0-0.00015 - As indicated in Table 1, the thermus thermophiles ferment is included in the composition in an amount of from about 0.5 to about 5 percent (%), by weight, based on the total weight of the composition. In some embodiments, for example without limitation, the composition comprises from about 1 to about 3% of thermus thermophiles ferment, or from about 1 to about 2, or from about 1.4 to about 1.6%, by weight, based on the total weight of the composition.
- As also indicated in Table 1, the silybin is included in the composition in an amount of from about 0.05 to about 0.5%, by weight, based on the total weight of the composition. In some embodiments, for example without limitation, the composition comprises from about 0.1 to about 0.3% of silybin, or from about 0.1 to about 0.2, or from about 0.10 to about 0.15%, by weight, based on the total weight of the composition.
- The compositions contemplated herein may, optionally, further comprise from 0 to about 0.5% of carnosine, by weight, based on the total weight of the composition. In some embodiments, for example without limitation, the composition comprises from about 0.01 to about 0.5% of carnosine, or from about 0.05 to about 0.4%, or from about 0.1 to about 0.3%, by weight, based on the total weight of the composition.
- The compositions contemplated herein may, optionally, further comprise from 0 to about 0.1% of adenosine, by weight, based on the total weight of the composition. In some embodiments, for example without limitation, the composition comprises from about 0.01 to about 0.08% of adenosine, or from about 0.02 to about 0.7%, or from about 0.03 to about 0.05%, by weight, based on the total weight of the composition.
- The compositions contemplated herein may, optionally, further comprise from 0 to about 0.00015% of CG-EDP3, by weight, based on the total weight of the composition. In some embodiments, for example without limitation, the composition comprises from about 0.00005 to about 0.00015% of CG-EDP3, or from about 0.000075 to about 0.000125%, or from about 0.0001 to about 0.000125%, by weight, based on the total weight of the composition.
- The compositions contemplated herein may further comprise a carrier which may be aqueous or non-aqueous. In one embodiment, an aqueous carrier comprises for example, without limitation, from about 30 to about 100% of water, by weight, based on the total weight of the carrier. A non-aqueous carrier may, for example without limitation, comprise from about 30 to about 100% of an organic liquid or gel, such as glycerol or another alcohol. The substances are dispersed in the carrier to be applied to the skin in a spreadable form (e.g., a lotion, gel or cream).
- In some embodiments, other substances are added to the skincare composition to improve its aesthetic qualities or promote skin health or healing. For example, without limitation, carriers, emulsifiers, humectants, lubricants, surfactants, thickeners, preservatives, moisturizers, and other additives may be included in the composition with one or more of the substances discussed hereinabove (i.e., thermus thermophiles ferment, silybin, carnosine, adenosine and CG-EDP3). Suitable emulsifiers include, without limitation, sorbitan monostearate, lecithin, and potassium phosphate. Suitable humectants include, without limitation, propylene glycol, propandiol, and glycerin. Suitable lubricants include, without limitation, glycerin, dimethicone and glyceryl oleate. Suitable surfactants include, without limitation, polyethylene glycol-100 stearate, glyceryl stearate, and potassium cetyl phosphate. Suitable thickeners include, without limitation, C12-C15 alkyl benzoate, carbomer and xantham gum. Suitable preservatives include, without limitation, potassium sorbate, phenoxyethanol, and chlorphenisin. Suitable moisturizers include, without limitation, dimethicone, caprylic or capric triglyceride, and capryl methicone.
- The exemplary compositions are easily and smoothly applied to the skin and provide improved anti-aging and reparative activity to the skin where applied. The exemplary compositions are expected to be non-irritating and soothing in normal use. Depending on the other substances that are included in the exemplary compositions, as will be readily understood by persons of ordinary skill in the relevant art, the compositions contemplated and described herein are useful for many purposes relating to skin care and repair, including without limitation, sunscreen, softening, moisturizing, exfoliating, wrinkle removal, scar removal, repairing damage, anti-aging, or treating infection.
- Formulation of a sample composition (“Test Product”) for application to the skin as a sunscreen, containing the substances listed in Table 2 below, will now be described.
-
TABLE 2 Quantity # Phase Ingredients (w/w %) 1 A WATER (AQUA) 51.41287 2 C CAPRYLYL METHICONE 4.000000 3 B DIPROPYLENE GLYCOL 4.000000 4 C DICAPRYLYL CARBONATE 3.000000 5 A2 PEG/PPG-17/6 COPOLYMER 2.000000 6 A3 POTASSIUM CETYL PHOSPHATE 1.562500 7 G THERMUS THERMOPHILUS FERMENT 1.408500 8 C GLYCERYL STEARATE 1.250000 9 C POLYETHYLENE GLYCOL-100 1.250000 STEARATE 10 C METHYL GLUCOSE SESQUISTEARATE 1.000000 11 G SD ALCOHOL 40-B (from Pride 1.000000 Solvents of Avenel, New Jersey) 12 A1 ACRYLATES/C10-30 ALKYL 0.200000 ACRYLATE CROSSPOLYMER 13 A2 ADENOSINE 0.400000 14 E C11-15 PARETH-40 0.050000 15 E C11-15 PARETH-7 0.050000 16 E CAPRYLYL GLYCOL 0.360000 17 H CARNOSINE 0.200000 18 C CETYL ALCOHOL 0.600000 19 A2 DIPOTASSIUM GLYCYRRHIZATE 0.050000 20a A2 DISODIUM EDTA 0.200000 20b C DISODIUM EDTA 0.020000 21 E DISODIUM LAURYL SULFOSUCCINATE 0.010000 22 I FRAGRANCE 0.050000 23 G GLYCERIN 0.275001 24 G GLYCINE SOJA (SOYBEAN) OIL 0.000000 25 G HEXYLENE GLYCOL 0.060000 26 G HYDROGENATED LECITHIN 0.000000 27 A3 HYDROGENATED PALM GLYCERIDES 0.937500 28 F ISOHEXADECANE 0.450000 29 B LECITHIN 0.180000 30 G OLIGOPEPTIDE-24 0.000000 31 A2 PANTHENOL 0.400000 32 C POLYETHYLENE GLYCOL-10 0.300000 DIMETHICONE 33a E PHENOXYETHANOL 0.050000 33b G PHENOXYETHANOL 0.395001 34 E POLYACRYLATE-15 0.350000 35 E POLYACRYLATE-17 0.150000 36 G POLYGONUM AVICULARE EXTRACT 0.180000 37 F POLYSORBATE 80 0.150000 38 D POTASSIUM HYDROXIDE 0.072625 39 G POTASSIUM SORBATE 0.128000 40 B SILYBIN 0.120000 41 F SODIUM ACRYLATE/SODIUM 0.750000 ACRYLOYLDIMETHYL TAURATE COPOLYMER 42 G SODIUM BENZOATE 0.018000 43 E SODIUM LAURETH-12 SULFATE 0.010000 44 G SODIUM OLEATE 0.000000 45 F SORBITAN OLEATE 0.050000 46 C TOCOPHERYL ACETATE 0.300000 47 C HOMOSALATE (HOMOMENTHYL 10.000000 SALICYLATE) 48 C ETHYLHEXYL SALICYLATE 5.000000 (OCTISALATE) 49 C BUTYL 3.000000 METHOXYDIBENZOYLMETHANE (AVOBENZONE) 50 C OCTOCRYLENE 2.600000 TOTAL 100.000000 - All ingredients are provided and combined as described below in amounts calculated to provide the weight percentage of the Test Product as reported in Table 2, which is based on the total weight of the Test Product.
- A large portion of cold deionized water is placed into a tank, with smaller portions held back to prepare Premix B, Premix C, Premix D and Premix H. Fast mixing is commenced to create a vortex and the Phase A1 substance (acrylates/C10-30 alkyl acrylate crosspolymer, #12) is slowly sprinkled into the tank with the water. During continuous mixing, the following Phase A2 substances are added to the tank: dipotassium glycyrrhizate (#19), adenosine (#13), disodium ethylenediaminetetraacetic acid (EDTA) (#20a), panthenol (#31), and PEG/PPG -17/6 copolymer (#5). Mixing is continued for 20 to 30 minutes, adjusting mixer speed as mixture thickens, until fully hydrated and uniform with no fish eyes. Heating to 80° C.-82° C. is commenced and mixing continues for 10 to 15 minutes until the mixture is uniform. The main tank with Premix A is covered and set aside.
- A small portion of water (#1) and all of the Phase B substances, silybin (#40), lecithin (#29) and dipropylene glycol (#3), are added to a stockpot and heated to 60° C.-65° C. while stirring with a mixer, for 5 to 10 minutes until uniform. The stockpot with Premix B is covered and set aside.
- A small portion of water (#1) and the Phase C substances are placed into a tank, heated to 80° C.-82° C., and stirred at slow to medium speed for 5 to 10 minutes until uniform. Phase C substances include: glyceryl stearate (#8), polyethylene glycol-100 stearate (#9), methyl glucose sesquistearate (#10), cetyl alcohol (#18), homosalate (#47), octocrylene (#50), butyl methoxydibenzoylmethane (#49), ethylhexyl salicylate (#48), disodium EDTA (#20b), dicaprylyl carbonate (#4), tocopheryl acetate (#46), polyethylene glycol dimethicone (#32) and caprylyl methicone (#2). The Phase C mixture is heated to 80° C.-82° C. while mixing on slow to medium mixing speed for 5 to 10 minutes, until uniform. The tank with Premix C is covered and set aside.
- A small portion of water (#1) and is added to a stockpot and, while stirring, potassium hydroxide (#38) is slowly added to the water in the stockpot. Premix D is stirred, for 5 to 10 minutes until the potassium hydroxide is dissolved and uniformly mixed, and then covered and set aside.
- A small portion of water (#1) and the Group H substance, carnosine (#17) are added to a stockpot and stirred for 5-10 minutes until completely dispersed. The stockpot with Phase H mixture is covered and set aside.
- The Premix A is added to a main tank, heated to 80° C.-82° C. and mixed. Then the
- Phase A3 substances, hydrogenated palm glycerides (#27) and potassium cetyl phosphate (#6), are added to the tank and mixed for 10 to 15 minutes until uniform. The Phase A mixture is cooled to 73° C.-75° C., while Premix B is reheated to 60° C.-65° C., if necessary. When both Premix A and Premix B reach the aforesaid temperatures, Premix B is added to Premix A in the main tank, while continuing to mix for another 5 to 10 minutes until uniform. The main tank and its contents are held at 73° C.-75° C.
- Premix C is reheated to 80° C.-82° C., if necessary, and then added to the main tank, while stirring continues.
- The contents of the main tank (i.e., Premixes A, B and C) are homogenized for 5 to 8 minutes. Premix D is then added to the main tank while homogenation mixing continues for another 3 to 5 minutes.
- The Phase E substances are then added to the main tank while homogenation mixing continues for another 3 to 5 minutes. The Phase E substances include C11-15 Pareth-40 (#14), C11-15 Pareth-7 (#15), caprylyl glycol (#16), disodium lauryl sulfosuccinate (#21), phenoxyethanol (#33a), polyacrylate-15 (#34), polyacrylate-17 (#35), and sodium laureth-12 sulfate (#43).
- Homogenation mixing is ceased and the main tank and its contents are cooled to 60° C.-63° C. The Phase F substances are premixed with one another. The Phase F substances include: isohexadecane (#28), polysorbate 80 (#37), sodium acrylate/sodium acryloyldimethyl taurate copolymer (#41), and sorbitan oleate (#45). After the main tank reaches the cooled temperature, the Phase F premix is added to the main tank and the mixture homogenized for 5 to 8 minutes.
- The main tank and its contents are cooled to 43° C.-45° C. and then, with continued stirring, the Group G substances were added: caprylyl glycol (#16), hexylene glycol (#25), phenoxyethanol (#33b), potassium sorbate (#39), SD Alcohol 40-B (#11), glycerin (#23), polygonum aviculare extract (#36), sodium benzoate (#42), Thermus thermophilus ferment (#7), oligopeptide-24 (#30), glycine soja (soybean) oil (#24), and sodium oleate (#44).
- Premix H (containing carnosine) is added to the main tank next, followed by the Phase I substance, Warm Sandalwood (#34), while stirring continues. The contents of the main tank are mixed for another 15 to 20 minutes until uniform and then cooled to 28° C.-30° C. Upon reaching the cooled temperature, the mixing is ceased.
- A study was performed using the Test Product formulated in Part A above on human subjects to test performance. More specifically, the study was designed to determine whether skin cell turnover (i.e., exfoliation) at skin sites treated with the Test Product was increased or improved compared to untreated sites.
- Dansyl chloride, a fluorescent blue- or blue-green substance was used at the untreated and treated skin sites to provide a means for measuring cell turnover at those sites. The dye fades as skin cells are lost from the surface of the skin during cell turnover. The faster the dye fades, the faster the cell turnover is occurring, and the faster skin regeneration is occurring.
- 35 human test subjects were initially enlisted for this study and randomly assigned a subject number of 1-35. There were 9 males, 26 females and a mix of ethnicities. 34 of the test subjects successfully completed the study. One test subject dropped out of the study for reasons unrelated to the study.
- All test subjects had dansyl chloride applied to a control test site on their upper arms by a trained individual. The dansyl chloride control sites remained otherwise untreated throughout the duration of the study.
- All evenly numbered test subjects also had dansyl chloride applied to a test site on their upper left arm. All oddly-numbered test subjects had dansyl chloride applied to a test site on their upper right arm. The Test Product was applied to the test site on each test subject, in 0.2 gram amounts. More particularly, each enrolled human subject had the Test Product applied by a trained clinical technician every weekday morning using a finger cot. The test subjects each applied the Test Product to the test site at home in the evening using a finger cot. There was no Test Product application on Saturday or Sunday. The volume of Test Product applied to the test site was sufficient to cover the area when rubbed in with the finger using a finger cot for approximately 10 scrubs.
- Each enrolled test subject was provided with instructions on washing of the test site. Washing of the test sites during the course of the study was done using Ivory Soap® provided by the testing facility.
- Each day of the study, both the control and the test sites were evaluated visually for intensity of the dansyl chloride staining and assigned a value based on the following visual assessment scale and the results are provided in Table 3 below.
- 0=No stain (except for fine hairs or follicles)
- 0.5=Barely perceptible evidence of stain (with or without more intense hair or follicle staining)
- 1=Partial or light stain (with or without more intense hair or follicle staining)
- 2=Moderate stain covering all of contact area (with or without more intense hair or follicle staining)
- 3=Intense, fully stained area
- (Intermediate scores of 1.5 and 2.5 were utilized when necessary)
- The study continued until no dansyl chloride stain was visible on any site with UV-light examination (Model B0100A Black-Ray Long Wave UV from Ultra-violet Products, Inc., San Gabriel, Calif., USA). When no dansyl chloride stain is discernable upon UV-light examination (i.e., when the intensity score above is 0) that is considered to be 100% cell turnover and is referred to as the point of extinction.
- A decrease in dansyl chloride stain intensity compared with the control site was observed for all test subject on Days 2-17 of the study. Overall, the test site treated with the Test Product was associated with a faster cell turnover than that observed on the control site on Days 2-17. The difference from the control site was statistically significant on Days 3-12.
- A comparison of the mean time until extinction was made between the test site and the control site using a paired difference t-test. The mean time to extinction (mean+/−standard error) are summarized below:
-
- Test Site: 10.2+/−0.2
- Control Site: 16.5+/−0.3
- It will be understood by those having ordinary skill in the art and possession of the present disclosure that the embodiments described herein are merely exemplary in nature and that a person skilled in the art may make many variations and modifications thereto without departing from the scope of the present invention. All such variations and modifications, are intended to be included within the scope of the invention.
Claims (15)
1. A skin care composition comprising thermus thermophiles ferment and silybin.
2. The skin care composition of claim 1 comprising:
from about 0.5 to about 5 percent by weight (wt %), of thermus thermophiles ferment, and
from about 0.05 to about 0.5 wt % of silybin, all weight percents based on the total weight of the composition.
3. The skin care composition of claim 1 , further comprising one or more substances selected from emulsifiers, humectants, lubricants, sufactants, dispersants, preservatives, moisturizers.
4. The skin care composition of claim 1 , further comprising a carrier.
5. The skin care composition of claim 4 , wherein the carrier is an aqueous carrier.
6. The skin care composition of claim 1 , further comprising one or more additional substances selected from carnosine, adenosine and CG-EDP3.
6. kin care composition of claim 6 , comprising:
from 0 to about 0.5 wt % of carnosine,
from 0 to about 0.1 wt % of adenosine, and
from 0 to about 0.00015 of CG-EDP3, all weight percents based on the total weight of the composition.
8. The skin care composition of claim 6 , further comprising a carrier.
9. The skin care composition of claim 8 , wherein the carrier is an aqueous carrier.
10. The skin care composition of claim 6 , further comprising one or more substances selected from emulsifiers, humectants, lubricants, sufactants, dispersants, preservatives, moisturizers.
11. The skin composition of claim 2 , comprising from about 1 to abou 2 wt % of thermus thermophiles ferment.
12. The skin composition of claim 2 , comprising from about 0.1 to about 0.2 wt % of silybin.
13. The skin composition of claim 7, comprising from about 0.05 to about 0.4 wt % of carnosine.
14. The skin composition of claim 7, comprising from about 0.02 to about 0.7 wt % of adenosine.
15. The skin composition of claim 7, comprising from about 0.000075 to about 0.000125 wt % of CG EDP3.
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CN114525230A (en) * | 2022-03-31 | 2022-05-24 | 杭州优玛达生物科技有限公司 | Fermentation culture and fermentation method of thermophilic thermus using fermentation culture |
CN115317391A (en) * | 2022-07-27 | 2022-11-11 | 旖帆(上海)实业有限公司 | Anti-wrinkle composition, anti-wrinkle essence cream applied to anti-wrinkle composition and preparation method of anti-wrinkle essence cream |
WO2024115001A1 (en) * | 2022-11-28 | 2024-06-06 | Unilever Ip Holdings B.V. | A personal care composition |
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DE4444238A1 (en) | 1994-12-13 | 1996-06-20 | Beiersdorf Ag | Cosmetic or dermatological drug combinations of cinnamic acid derivatives and flavone glycosides |
AUPR038200A0 (en) | 2000-09-26 | 2000-10-19 | Beta Peptide Foundation Pty Ltd, The | Compositions and methods for delaying, preventing, rejuvenating or reversing senescence |
FR2821086B1 (en) | 2001-02-21 | 2003-12-12 | Sederma Sa | PROCESS FOR THE MANUFACTURE OF PROTEINS BY FERMENTATION OF MICROORGANISMS OF THE THERMUS FAMILY, MIXTURE OF PROTEINS THUS OBTAINED AND COSMETIC COMPOSITION CONTAINING THEM |
EP1382326A1 (en) | 2002-07-17 | 2004-01-21 | Cognis France S.A. | Method of protecting the skin against ageing |
TWI256893B (en) | 2003-03-25 | 2006-06-21 | Fancl Corp | Composition for promoting production of type I collagen and/or elastin |
US20060286046A1 (en) | 2005-01-05 | 2006-12-21 | Haber C Andrew | Skin care compositions |
FR2881953A1 (en) | 2005-02-11 | 2006-08-18 | Greenpharma Sa Sa | USE OF TAXIFOLINE DERIVATIVES AS PIGMENTANTS AND PROTECTIVE AGENTS FOR SKIN OR HAIR |
DE102005048778A1 (en) * | 2005-10-10 | 2007-04-12 | Beiersdorf Ag | Cosmetic formulations to improve the appearance of the skin |
EP1902756A1 (en) | 2006-09-19 | 2008-03-26 | Cognis IP Management GmbH | Composition and method for treating skin by administering silybin and piperine/terahydropiperine |
FR2944435B1 (en) * | 2009-04-17 | 2011-05-27 | Sederma Sa | COSMETIC COMPOSITION COMPRISING ORIDONIN |
RU2503446C2 (en) | 2012-02-07 | 2014-01-10 | Алексей Валентинович Одинцов | Hair growth product (versions) and methods of treating alopecia |
FR3004351B1 (en) | 2013-04-16 | 2015-03-27 | Sederma Sa | PREVENTION AND TREATMENT OF SKIN DAMAGE ASSOCIATED WITH INFRA-RED |
US9956163B2 (en) | 2014-06-12 | 2018-05-01 | Colorescience, Inc. | Formulations for lightening skin and treating hyperpigmentation |
FR3024037B1 (en) * | 2014-07-25 | 2018-03-02 | Sederma | COSMETIC OR DERMATOLOGICAL ACTIVE INGREDIENT COMPRISING A MIXTURE OF UNSATURATED FATTY DICARBOXYLIC ACIDS, COMPOSITIONS COMPRISING THE SAME, AND COSMETIC OR DERMATOLOGICAL USES |
US9089505B1 (en) * | 2014-10-14 | 2015-07-28 | Jan Marini Skin Research | Skin firming cream |
CN104382833B (en) | 2014-10-28 | 2015-11-18 | 广东碧嫄化妆品有限公司 | Plant protein peptide stock solution and its preparation method and application |
US9693947B1 (en) | 2017-02-03 | 2017-07-04 | Jan Marini Skin Research | HYLA3D hylauronic acid activating complex |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN114525230A (en) * | 2022-03-31 | 2022-05-24 | 杭州优玛达生物科技有限公司 | Fermentation culture and fermentation method of thermophilic thermus using fermentation culture |
CN115317391A (en) * | 2022-07-27 | 2022-11-11 | 旖帆(上海)实业有限公司 | Anti-wrinkle composition, anti-wrinkle essence cream applied to anti-wrinkle composition and preparation method of anti-wrinkle essence cream |
WO2024115001A1 (en) * | 2022-11-28 | 2024-06-06 | Unilever Ip Holdings B.V. | A personal care composition |
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