US20160235284A1 - Endoscope lens cleaner - Google Patents
Endoscope lens cleaner Download PDFInfo
- Publication number
- US20160235284A1 US20160235284A1 US15/025,678 US201415025678A US2016235284A1 US 20160235284 A1 US20160235284 A1 US 20160235284A1 US 201415025678 A US201415025678 A US 201415025678A US 2016235284 A1 US2016235284 A1 US 2016235284A1
- Authority
- US
- United States
- Prior art keywords
- endoscope
- cleaner
- endoscopic
- antifoulant
- attachment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004140 cleaning Methods 0.000 claims abstract description 60
- 239000002519 antifouling agent Substances 0.000 claims abstract description 47
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 31
- 230000003373 anti-fouling effect Effects 0.000 claims abstract description 28
- 238000012976 endoscopic surgical procedure Methods 0.000 claims abstract description 25
- 238000011282 treatment Methods 0.000 claims abstract description 21
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- 239000004094 surface-active agent Substances 0.000 claims description 47
- 238000000034 method Methods 0.000 claims description 26
- 238000012323 Endoscopic submucosal dissection Methods 0.000 claims description 14
- 238000009825 accumulation Methods 0.000 claims description 13
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- 238000012326 endoscopic mucosal resection Methods 0.000 claims description 4
- 238000001356 surgical procedure Methods 0.000 abstract description 6
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- 229920001223 polyethylene glycol Polymers 0.000 description 27
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Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/74—Carboxylates or sulfonates esters of polyoxyalkylene glycols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/12—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with cooling or rinsing arrangements
- A61B1/126—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with cooling or rinsing arrangements provided with means for cleaning in-use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00064—Constructional details of the endoscope body
- A61B1/00071—Insertion part of the endoscope body
- A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
- A61B1/00089—Hoods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00064—Constructional details of the endoscope body
- A61B1/00071—Insertion part of the endoscope body
- A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
- A61B1/00091—Nozzles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/012—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor characterised by internal passages or accessories therefor
- A61B1/018—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor characterised by internal passages or accessories therefor for receiving instruments
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/825—Mixtures of compounds all of which are non-ionic
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/22—Organic compounds
- C11D7/26—Organic compounds containing oxygen
- C11D7/265—Carboxylic acids or salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00269—Type of minimally invasive operation endoscopic mucosal resection EMR
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/667—Neutral esters, e.g. sorbitan esters
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D2111/00—Cleaning compositions characterised by the objects to be cleaned; Cleaning compositions characterised by non-standard cleaning or washing processes
- C11D2111/10—Objects to be cleaned
- C11D2111/14—Hard surfaces
- C11D2111/20—Industrial or commercial equipment, e.g. reactors, tubes or engines
Definitions
- the present invention relates to a cleaner for cleaning various types of medical endoscopes, including laryngoscopes, bronchoscopes, upper gastrointestinal endoscopes, lower gastrointestinal endoscopes, duodenoscopes, enteroscopes, colonoscopes, capsule endoscopes, thoracoscopes, laparoscopes, cystoscopes, cholangioscopes, arthroscopes, spinal endoscopes, angioscopes, epiduroscopes, magnifying endoscopes, ultrasonic endoscopes, side-viewing endoscopes, oblique-viewing endoscopes, etc.
- the present invention relates to a cleaner for cleaning such various types of endoscopes inside a living body during a surgical procedure.
- the present invention also relates to an antifoulant useful for antifouling treatment of such an endoscope before use.
- Endoscopic diagnosis and treatment are applied to, for example, nasal cavity, pharynx, larynx, esophagus, trachea, bronchus, upper and lower gastrointestinal tract, thorax, abdominal cavity, renal pelvis and ureter, bile duct, joints, spine, blood vessels, subdural space, etc.
- Patent Literature 1 discloses a cleaner for an endoscope, comprising a nonionic surfactant and an enzyme
- Patent Literature 2 discloses a cleaning composition for medical devices, comprising a nonionic polymer, a nonionic surfactant, ethylenediaminetetraacetic acid and monoethanolamine.
- the cleaning ability of these cleaners is not effective enough for removing the debris from the lens.
- An endoscope hood is sometimes attached to ensure a clear endoscopic view.
- An endoscope hood (attachment) is a cap to be attached to the distal end of an endoscope.
- An endoscope hood has regained attention as a necessary tool for magnification endoscopy and therapeutic endoscopy, which have recently been widely performed.
- Such an endoscope hood (attachment) also suffers from, the same problem as an endoscope lens. That is, debris composed of blood, body fluid, gastric juice, saliva and cell debris as well as of fatty tissue released by resection of the affected site accumulates on the hood and results in a blurred endoscopic view. Therefore, there has also been a demand for the development of an endoscope hood cleaner with high cleaning ability and high safety for use inside a living body.
- Patent Literature 1 JP 2001-031999 A
- Patent Literature 2 JP 2009-144070 A
- An object of the present invention is therefore to reduce the burden on a physician and the patient in endoscopic diagnosis and treatment and to provide a cleaner to be used inside a living body during an endoscopic surgical procedure.
- Another object of the present invention is to provide a cleaner with a high ability to clean debris from an endoscope lens and/or an endoscope hood (attachment).
- a further object of the present invention is to provide an antifoulant useful for antifouling treatment of an endoscope and/or endoscopic accessories, such as an endoscope lens and/or an endoscope hood (attachment).
- the present invention relates to the following.
- a cleaner for an endoscope the cleaner being used inside a living body during an endoscopic surgical procedure.
- the cleaner of the above (1) comprising a surfactant.
- the cleaner of the above (1) comprising no surfactant.
- the cleaner of any one of the above (1) to (3) for removal of debris from an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)).
- the cleaner of the above (2) to (4) comprising (i) a nonionic surfactant with an HLB of 1 to 11 and (ii) a nonionic surfactant with an HLB of 11 to 20.
- the cleaner of any one of the above (1) to (5) comprising at least one type of a detergent builder.
- the cleaner of the above (1) to (8) which is delivered from a water nozzle, a forceps channel or a water-jet nozzle of an endoscope.
- the present invention also includes a method for cleaning an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) with the cleaner inside a living body during an endoscopic surgical procedure [or a method for cleaning an endoscope and/or endoscopic: accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) to remove accumulated debris thereon (for example, blood, body fluid, gastric juice, saliva, cell debris, fatty tissue, etc.)].
- a method for cleaning an endoscope and/or endoscopic accessories in particular, an endoscope lens and/or an endoscope hood (attachment)
- accumulated debris thereon for example, blood, body fluid, gastric juice, saliva, cell debris, fatty tissue, etc.
- the present invention also includes an antifoulant for antifouling treatment Of an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)).
- the antifoulant is an agent (composition) that is applied to an endoscope or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) outside a living body before they are inserted into the body, thereby reducing or preventing the accumulation of debris on the endoscope or the endoscopic accessories inside the living body during an endoscopic surgical procedure.
- the components of the antifoulant may be the same as those contained in the above cleaner.
- the antifoulant may typically comprise (1) a nonionic surfactant with an HLE of 1 to 11 and (ii) a nonionic surfactant with an RLE of 11 to 20.
- the antifoulant may further comprise an antifoulant builder (such as the same components as those used as detergent builders, for example, sodium, hydrogen carbonate).
- an antifoulant builder such as the same components as those used as detergent builders, for example, sodium, hydrogen carbonate.
- the present invention also includes a method for subjecting an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) to antifouling treatment with the antifoulant for a method for reducing or preventing the accumulation of debris (for example, blood, body fluid, gastric juice, saliva, cell debris, fatty tissue, etc.) on an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) inside a living body during an endoscopic surgical procedure, the -method comprising subjecting the endoscope and/or the endoscopic accessories to antifouling treatment before the surgical procedure].
- debris for example, blood, body fluid, gastric juice, saliva, cell debris, fatty tissue, etc.
- the method may be combined with the above cleaning method. That is, the above methods may be a combined method comprising subjecting an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) to antifouling treatment with the antifoulant before use, and then cleaning the endoscope and/or the endoscopic accessories (in particular, the endoscope lens and/or the endoscope hood (attachment)) inside a living body during an endoscopic surgical procedure [or a method for preventing the accumulation of debris on an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) and removing debris inside a living body during an endoscopic surgical procedure, the method comprising cleaning the endoscope and/or the endoscopic accessories before and during the surgical procedure].
- an endoscope and/or endoscopic accessories in particular, an endoscope lens and/or an endoscope hood (attachment)
- the method comprising cleaning the endoscope and/
- the endoscopic surgical procedure in the present invention (in particular, in use of the: cleaner or the cleaning method, or the antifoulant or the antifouling treatment method) is not particularly limited, and may be, for example, endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD).
- EMR endoscopic mucosal resection
- ESD endoscopic submucosal dissection
- ESD is a surgical operation for tumors located in sites inaccessible to resection by SMR or for large tumors. ESD requires longer hours of operation and is thus more susceptible to the accumulation of debris. Hence the present invention may be appropriately used in, in particular, ESD.
- the present invention provides a cleaner that is highly safe for use inside a living body so that the cleaner can be used inside a living body during an endoscopic surgical procedure.
- the cleaner of the present invention has a high ability to clean debris from an endoscope and/or endoscopic accessories (in particular, from an endoscope lens and/or an endoscope hood) and provides antifogging effect to an endoscope lens.
- the present invention also provides an antifoulant useful for antifouling treatment of an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) outside a living body before they are inserted into the body for an endoscopic surgical procedure.
- the antifoulant has excellent antifouling ability and reduces or prevents the accumulation of debris on an endoscope lens and/or an endoscope hood (attachment).
- the present invention greatly reduces the burden on a physician and the patient during an endoscopic surgical procedure.
- FIG. 1 is a schematic view of the distal end (with a lens) of an endoscope.
- FIG. 2 is a schematic view of the endoscope distal end with an attached endoscope hood.
- FIG. 3 shows the results of Test Example 3 (cleaning effect on oil film on endoscope lenses).
- FIG. 4 shows the results of Test Example 4 (cleaning effect on oil film on endoscope hoods (attachments)).
- FIG. 5 shows the results of Test Example 5 (antifogging effect).
- FIG. 6 shows endoscopic photographs used as an indicator for the evaluation of debris accumulated on the endoscope lens after endoscopic submucosal dissection
- FIG. 7 shows endoscopic photographs used as an indicator for the evaluation of the amount of fat in the submucosal adipose tissue
- the present invention relates to a cleaner for an endoscope, the cleaner being used inside a living body during an endoscopic surgical procedure.
- the term “endoscopic surgical procedure” herein includes any: types of diagnosis, treatment and prevention using an endoscope.
- the cleaner of the present invention comprises a cleaning component in such a manner that high safety for use inside a living body is ensured and that the cleaner exhibits a sufficient ability to clean debris from an endoscope lens and/or an endoscope hood (attachment).
- the cleaning component is not particularly limited, and the cleaner may comprise various types of known cleaning components. Such cleaning components can also be used as antifouling components as described later.
- the cleaner of the present invention may comprise a surfactant, but it is not essential.
- the cleaner of the present invention may comprise, if desired, one or more of a detergent builder (hereinafter also called a builder), a preservative, a solubilizing agent or an emulsifier, a viscosity modifier and an antioxidant.
- a detergent builder hereinafter also called a builder
- the builder is not particularly limited, and may be an inorganic builder or an organic builder.
- the inorganic builder include carbonates, sulfates, hydrochlorides, phosphates, and borates of alkali metals and alkaline earth metals and boric acid. More specific examples thereof include sodium hydroxide, sodium sulfate, magnesium sulfate, sodium chloride, magnesium chloride, carbonates (such as sodium carbonate), hydrogen carbonates (such as sodium hydrogen carbonate), phosphates (such as sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, dipotassium phosphate, and potassium dihydrogen phosphate), sodium tripolyphosphate, sodium pyrophosphate, potassium pyrophosphate, sodium hexametaphosphate, borax, boric acid, magnesium carbonate, calcium carbonate, and calcium sulfate. Of these, preferred are sodium hydrogen carbonate, sodium phosphate, sodium monohydrogen phosphate, and potassium dihydrogen phosphate due to their ability to increase the cleaning effect.
- organic builder examples include carboxylic acids, hydroxycarboxylic acids, polycarboxylic acids, hydroxypolycarboxylic acids and salts thereof, and aminocarboxylic acids, aminopolycarboxylic acids, and salts thereof, each having 2 to 10 carbon atoms. More specific examples thereof include organic acids such as citric acid, malic acid, succinic acid, maleic acid, fumaric acid, gluconic acid and adipic acid and salts thereof and aminopolycarboxylic acids such as ethylenediaminetetraacetic acid and nitrilotriacetic acid and salts thereof. Examples of the organic builder further include sugars such as glucose, sucrose, fructose, and lactose; and ureas.
- these builders can be used alone or in combination of two or more of them.
- the builders can also serve as a pH adjuster.
- the builders can also be used as an antifouling component (or an antifoulant builder) as described later,
- the amount of the builder(s) contained in the cleaner is not particularly limited, and may be, for example, typically less than 3% by mass based on the total mass of the cleaner, and to sufficiently achieve the intended effects, the amount is preferably 0.01 to 0.6% by mass and more preferably 0.05 to 0.3% by mass.
- the preservative is not particularly limited and examples thereof include benzoic acid and salts thereof, salicylic acid and salts thereof, sorbic acid and salts thereof, denydroacetic acid and salts thereof, p-hydroxybenzoic acid esters such as p-hydroxybenzoic acid alkyl esters (e.g., methylparaben, ethylparaben, propylparaben, butylparaben, etc.), 2, 4,4′-trichloro-2′-hydroxydiphenyl ether, 3,3,4′-trichlorocarbanilide, hexachlorophene, benzalkonium, chloride, phenoxyethanol, hinokitiol, resorcin, ethanol, 1,3-butylene glycol, isopropylrnethylphenol, and polyhydric alcohols such as 1,3-botylene glycol, 1,2-pentanediol, 1,2-hexanediol, and 1,2-oc
- the solubilizing agent or the emulsifier is not particularly limited and examples thereof include dimethylisosorbide, transcutol, ethyl alcohol, isopropyl alcohol, polyethylene glycol, propylene glycol, castor oil, isopropyl, myristate, octyldodecanol, isocetyl alcohol, oleyl alcohol, oleyl cetyl alcohol; triglycerides of medium-chain fatty acids derived from plants, such as caprylic triglyceride and capric triglyceride, Miglyols(R), which is a mixture of propylene glycol dicaprylate and propylene glycol dicaprate, Neobee M-5, which is a mixture of caprylic triglyceride and capric triglyceride; polysorbates such as polysorbate 20, polysorbate 40, polysorbate 60, and polysorbate 80; sorbitans such as sorbitan laurate, sorbit
- the viscosity modifier is not particularly limited and examples thereof include cetyl alcohol, stearyl alcohol, cetyl stearyl alcohol, myristyl alcohol, xanthan gum, VEEGUM (magnesium, aluminum silicate), carbomer, glyceryl stearate, hydrogenated castor oil, cetyl palmitate, stearic acid, a combination of synthetic and semisynthetic wax, a combination of glyceryl stearate, stearyl alcohol, cetyl palmitate, and cocoglycerides blend, and a combination of glyceryl, hydroxystearate, cetyl palmitate, and trihydroxystearin blend. These viscosity modifiers may be used alone or in combination of two or more of them.
- the antioxidant used in the present invention is not particularly limited and examples thereof include ascorbic acid, phosphate derivatives of ascorbic acid, and salts thereof, stearic acid esters, tocopherol and derivatives thereof, butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), hydroxytyrosol, p-hydroxyanisole, propyl gallate, sesamol sesamolin, and gossypol.
- the solvent used for the production of the cleaner of the present invention is not particularly limited and examples thereof include water, and lower alcohols, ether alcohols, glycols and ketones, each of which has 1 to 6 carbon atoms, such as methane), ethanol, propanol, isopropyl alcohol, ethylene glycol, propylene glycol, diethylene glycol, methyl glycol, ethyl glycol, butyl glycol, glycerol, concentrated glycerol, acetone, and methyl ethyl ketone.
- the water may be tap water, purified water, sterile purified water, or sterile water. Of these solvents, water, in particular, purified water, sterile purified water, and sterile water are preferred in view of safety to a living body.
- the pH of the cleaner of the present invention is not particularly limited, and may be, for example, typically 3 to 12, and is preferably 4 to 10 and more preferably 6 to 9, in view of safety to a living body and in order to enhance the cleaning effect.
- the viscosity of the cleaner of the present invention is not particularly limited, and may be, for example, typically 1 to 500 mPa ⁇ s, and is preferably 1 to 200 mPa ⁇ s in view of clinical convenience.
- One embodiment, of the present invention relates to the cleaner comprising a surfactant as a cleaning component.
- the surfactant used in the present invention may he any surfactant as long as the effects of the present invention are achieved.
- the surfactant may be, for example, a combination of nonionic surfactants with different HLBs values.
- hydrophile-lipophile balance herein is an index indicating the hydrophilicity of a nonionic surfactant.
- the HLB value can he calculated by any of the following formulas:
- the HLB value ranges from 0 to 20, and an HLB value closer to 20 indicates higher hydrophilicity.
- the cleaner comprises (i) a nonionic surfactant with an HLB of 1 to 11 and (ii) a nonionic surfactant with an HLB of 11 to 20 (for example, 12 to 19, preferably 13 to 18).
- the nonionic surfactant (i) is not particularly limited and examples thereof include the following (the numbers in the brackets ([ ])) represent the HLB values): monoglyceride [2.6 to 3,5], sorbitan monocaprylate [9, 6], sorbitan monolaurate [8.6], sorbitan monopalmitate [6.7], sorbitan monostearate [4.7], sorbitan monooleate [4.3], sorbitan trioleate [1.8], sorbitan trioleate with 20 mol EO [11.0], sorbitan monooleate with 5-mol EO [10.0], sorbitan monostearate with 4 mol EO [9.6], polysorbate 65 [10.5], polyethylene glycol (200) monolaurate [9.8], polyethylene glycol (200) monostearate [8.5], polyethylene glycol (200) monooleate [8.4], polyethylene glycol (200) dilaurate [6.6], polyethylene glycol (400) dilaurate [9.8
- surfactants may be used alone or in combination of two or more of them.
- the nonionic surfactant (ii) is not particularly limited and examples thereof include the following: sorbitan monolaurate with 4 mol EO [13.3], sorbitan monolaurate with 20 mol EO [16.7], sorbitan monopalmitate with 20 mol EO [15.6], sorbitan monostearate with 20 mol EO [14.9], sorbitan monooleate with 20 mol EO [15.0], polysorbate 20 [16.0 to 16.9], polysorbate 40 [15.6 to 16.0], polysorbate 60 [14.9 to 15.7], polysorbate 80 [15.0 to 15.7], polyethylene glycol (400) monolaurate [13.1], polyethylene glycol (600) monolaurate [14.8], polyethylene glycol (1000) monolaurate [16.5], polyethylene glycol (400) monostearate [11.9], polyethylene glycol (600) monostearate [13.8], polyethylene glycol (1000) monostearate [15.8], polyethylene glycol (400)
- surfactants may be used alone or in combination of two or more of them.
- these surfactants in view of safety to a living body, preferred are decaglycerol monocaprylate [16.0], decaglycerol monolaurate [14.8], hexaglycerol monooleate [11.6], decaglycerol monolaurate [15.6], decaglycerol monomyristate [14.6], sucrose stearate [15 to 16], sucrose palmitate [15 to 16], sucrose myristate [16], sucrose oleate [15], sucrose laurate [about 16], etc.
- EO represents ethylene oxide
- the total amount of the nonionic surfactants contained in the cleaner is typically 0.1 to 40% by mass, preferably 1 to 35% by mass, more preferably 3 to 30% by mass, and particularly preferably 5% by mass or more (for example, 5 to 40% by mass, preferably 6 to 35% by mass, and further more preferably 7 to 30% by mass), based on the total weight of the cleaner.
- the cleaner containing the nonionic surfactants in such a total amount exhibits a sufficient cleaning effect and is sufficiently safe for use inside a living body.
- the total amount of the surfactants may be appropriately selected depending on the combination of the surfactants to be used.
- the ratio of the nonionic surfactants (i):(ii) contained in the cleaner is, in terms of mass, typically 2:1 to 1:10, preferably 1:1 to 1:9, and more preferably 1:2 to 1:7.
- the cleaner containing the surfactants in such a ratio exhibits high cleaning effect.
- the combined HLB value of the nonionic surfactants (i) and (ii) is typically 11.1 to 16.0, preferably 13.0 to 15.5, and more preferably 13.6 to 15.3.
- the cleaner containing the surfactants with such a combined HLB value exhibits high cleaning effect.
- the nonionic surfactants (i) and (ii) contained in the cleaner of the present invention has a combined HLB value of 13.6 to 15.3, a mass ratio (i):(ii) of 1:2 to 1:7, and a total amount of 3 to 30% by mass based on the total amount of the cleaner.
- the nonionic surfactant (i) is at least one type selected from the group consisting of diglycerol monocaprylate, tetraglycerol monooleate, and tetraglycerol monolaurate, and that the nonionic surfactant (ii) is at least one type selected from the group consisting of decaglycerol monocaprylate, decaglycerol monolaurate, hexaglycerol monooleate, decaglycerol monolaurate, and decaglycerol monomyristate.
- the cleaner of the present invention comprising the surfactant (a) as a cleaning component may comprise, if desired, a builder, a preservative, a solubilizing agent or an emulsifier, a viscosity modifier, an antioxidant, a defoaming agent, etc.
- the builder, the preservative, the solubilizing agent or the emulsifier, the viscosity modifier, and the antioxidant may be the same as those described above.
- the solvent to be used and the viscosity and pH of the cleaner may also be the same as those described above.
- the ratio of the detergent builder (for example, an inorganic builder such as sodium hydrogen carbonate) relative to 100 parts by mass of the surfactant(s) may be selected from the range of, for example, about 0,01 to 100 parts by mass (for example, about 0.03 to 50 parts by mass), and is preferably about 0.05 to 30 parts by mass, more preferably about 0.1 to 20 parts by mass, and particularly preferably about 0.5 to 20 parts by mass (for example, about 1 to 10 parts by mass).
- the defoaming agent is not particularly limited and examples thereof include alcohols (such as methanol, ethanol, 1 -propanol, 2-propanol, lauryl alcohol, and stearyl alcohol) and silicone compounds (such as dimethyl silicone, fluorosilicone, and polyether silicone). Of these defoaming agents, dimethyl silicone is preferred due to its defoaming performance and in view of safety to a living body.
- alcohols such as methanol, ethanol, 1 -propanol, 2-propanol, lauryl alcohol, and stearyl alcohol
- silicone compounds such as dimethyl silicone, fluorosilicone, and polyether silicone.
- dimethyl silicone is preferred due to its defoaming performance and in view of safety to a living body.
- the cleaner comprising no surfactant.
- the components in the cleaner of the present invention are not particularly limited, and the cleaner may comprise, as a cleaning component, for example, an inorganic compound such as a carbonate, a sulfate, a hydrochloride, a phosphate or a borate of an alkali metal or an alkaline earth metal, or boric acid; or an organic compound such as a carboxylic acid, a hydroxycarboxylic acid, a polycarboxylic acid or a hydroxypolycarboxylic acid, or a salt thereof, or an aminocarboxylic acid or an aminopolycarboxylic acid, or a salt thereof, each having 2 to 10 carbon atoms.
- an inorganic compound such as a carbonate, a sulfate, a hydrochloride, a phosphate or a borate of an alkali metal or an alkaline earth metal, or boric acid
- an organic compound such as a carboxylic acid, a
- the inorganic compound used as a cleaning component is not particularly limited and specific examples thereof include sodium sulfate, magnesium sulfate, sodium chloride, magnesium chloride, sodium carbonate, sodium hydrogen carbonate, sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, sodium tripolyphosphate, sodium pyrophosphate, potassium pyrophosphate, sodium hexametaphosphate, borax, boric acid, magnesium carbonate, calcium carbonate, and calcium sulfate.
- the organic compound used as a cleaning component is not particularly limited and specific examples thereof include carboxylic acids, hydroxycarboxylic acids, polycarboxylic acids, hydroxypolycarboxylic acids and salts thereof, and aminocarboxylic acids, aminopolycarboxylic acids, and salts thereof, each having 2 to 10 carbon atoms. More specific examples thereof include organic acids such as citric acid, malic acid, succinic acid, maleic acid, fumaric acid, gluconic acid and adipic acid and salts thereof; and aminopolycarboxylic acids such as ethylenediaminetetraacetic acid and nitrilotriacetic acid and salts thereof. Examples of the organic compound further include sugars such as glucose, sucrose, fructose, and lactose; and ureas.
- the above cleaning components may be used alone or in combination of two or more of them.
- two or more of the cleaning components are preferably used in combination.
- the combination of the cleaning components is not particularly limited and examples of thereof include a combination of sodium hydrogen carbonate and sodium hexametaphosphate and a combination of sodium hydrogen carbonate and sodium citrate. In the present invention, such a combination of the cleaning components may be used together with a surfactant.
- the total amount of the cleaning components contained in the cleaner is not particularly limited and may be, for example, 0.01 to 10% by mass based on the total amount of the cleaner of the present invention.
- the blending ratio may be any ratio as long as the cleaning effect is sufficiently achieved, in cases where, for example, two types of the cleaning components are used in combination, the blending ratio in terms of mass may be 1:1 to 1:5.
- the cleaning component(s) preferably also serves as a buffering agent.
- the cleaner of the present invention comprising no surfactant may further comprise, if desired, an alkali for the purpose of adjusting the pH.
- an alkali for the purpose of adjusting the pH.
- the alkali include sodium hydroxide, potassium hydroxide, lithium hydroxide, sodium carbonate, potassium carbonate, ammonium carbonate, and a combination thereof.
- the cleaner of the present invention comprising no surfactant may comprise, if desired, a builder, a preservative, a solubilizing agent or an emulsifier, a viscosity modifier, an antioxidant, etc.
- the builder, the preservative, the solubilizing agent or the emulsifier, the viscosity modifier and the antioxidant may be the same as those described above.
- the solvent to be used and the viscosity and pH of the cleaner may also be the same as those described above.
- the cleaner of the present invention comprising no surfactant hardly foams during cleaning even without the addition of a defoaming agent.
- the cleaner of the present invention (comprising or not comprising a surfactant) is suitable for the removal of debris accumulated on an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) inside a living body during an endoscopic surgical procedure.
- the delivery of the cleaner for the removal of debris from an endoscope lens can be done by any means, including, for example, an air/water nozzle (hereinafter simply called, “a water nozzle”, see numeral 5 in FIG. 1 ), a forceps channel (see numeral 3 in FIG. 1 ), a water-jet nozzle (see numeral 4 of FIG. 1 ), etc. of an endoscope.
- the delivery means may be appropriately selected depending on the purpose.
- the endoscope hood (attachment) in the present invention is not particularly limited, and may be, for example, an attachment that is attached to an endoscope as shown in numeral 6 of the schematic view in FIG. 2 .
- the material, color, shape, etc. of the endoscope hood may be appropriately selected as desired.
- Specific examples of the endoscope hood (attachment) include slit & hole type or straight type of Elastic Touch (registered trademark) made by Top Corporation; various types of hoods of Mole Cap (registered trademark) made by Top Corporation; etc.
- the removal of debris from the endoscope lens and the endoscope hood (attachment) is preferably done by, for example, spraying the cleaner on the endoscope hood (attachment) from a spray nozzle etc. inserted through the forceps channel.
- the spray nozzle is not particularly limited, and specific examples thereof include the spray nozzle of Fine Jet (registered trademark) made by Top Corporation, etc.
- the removal of debris is done by, for example, deflecting the distal end upward with its face up and injecting the cleaner from the forceps channel so that the cleaner is kept in the endoscope hood (attachment) (i.e., the endoscope lens is kept immersed in the cleaner); or pressing the edge of the endoscope hood (attachment) against the inner wall of a cavity of a living body and injecting the cleaner so that the hood is filled with the cleaner.
- the cleaner kept in the hood may be stirred with, for example, a stirring stick etc. inserted through the forceps channel.
- the cleaner of the present invention after used to remove the debris from an endoscope lens and/or an endoscope hood (attachment) also exhibits a function of providing antifogging effect to the endoscope lens and/or the endoscope hood (attachment).
- a physician can remove debris from an endoscope lens and/or an endoscope hood (attachment) during a surgical procedure without withdrawing the endoscope outside the body.
- the physician does not need to stop the procedure, and consequently the burden on the physician and the patient is greatly reduced.
- the cleaner (or its components) of the present invention can also be used as an antifoulant (a surface treating agent, an antifouling treatment agent, or a surface protective agent) for an endoscope and/or endoscopic accessories (or endoscope attachments), in particular, for an endoscope lens and/or an endoscope hood (attachment).
- an antifoulant a surface treating agent, an antifouling treatment agent, or a surface protective agent
- an endoscope lens and/or an endoscope hood, etc. may be subjected to antifouling treatment using the cleaner (or its components) as an antifoulant [i.e., antifouling treatment in which, for example, the cleaner is applied to an endoscope lens and/or an endoscope hood (or the cleaner is allowed to adhere thereto)] outside a living body before the endoscope is inserted into the body.
- This antifouling treatment reduces or prevents the accumulation of various debris components (for example, fat etc.) on the endoscope lens and/or the endoscope hood (attachment), etc. inside the living body during an endoscopic surgical procedure.
- the antifoulant can also provide antifogging effect to an endoscope lens and/or an endoscope hood (attachment), etc. Therefore, the antifoulant of the present invention can also be used as an antifogging agent (an antifouling and antifogging agent).
- the components of the antifoulant may be the same as those of the above cleaner, and their content ratios are the same as described above.
- a surfactant is particularly suitable as an antifouling component.
- the antifoulant may comprise, as an antifouling component, the above-described surfactant, for example, a surfactant combination of (i) a nonionic surfactant with an HLB of 1 to 11 and (ii) a nonionic surfactant with an HLB of 11 to 20 (for example, 12 to 19, preferably 13 to 18).
- the total amount of the nonionic surfactants may be typically 0.1 to 40% by mass, and is preferably 1 to 35% by mass, more preferably 3 to 30% by mass, and particularly preferably 5% by mass or more (for example, 5 to 40% by mass, preferably 6 to 35% by mass, and further more preferably 7 to 30% by mass), based on the total weight of the antifoulant.
- the ratio of the nonionic surfactants (i):(ii) contained in the antifoulant may be, in terms of mass, typically 2:1 to 1:10, preferably 1:1 to 1:9, more preferably 1:2 to 1:7.
- the combined HLB value of the nonionic surfactants (i) and (ii) may be typically 11.1 to 16.0, and is preferably 13.0 to 15.5, and more preferably 13.6 to 15.3.
- the nonionic surfactants (i) and (ii) contained in the antifoulant of the present invention may have a combined HLB value of 13.6 to 15.3, a mass ratio of 1:2 to 1:7, and a total amount of 3 to 30% by mass based on the total amount of the cleaner.
- the antifoulant may comprise the above-described builder (sodium hydrogen carbonate etc.) as an antifoulant builder.
- the ratio of the antifoulant builder relative to 100 parts by mass of the surfactant(s) can be selected from the range of about 0.01 to 100 parts by mass (for example, about 0.03 to 50 parts by mass), and is preferably about 0.05 to 30 parts by-mass, more preferably about 0.1 to 20 parts by mass, and in particular may be about 0.5 to 20 parts by mass (for example, about 1 to 10 parts by mass).
- the antifoulant of the present invention may be the same as the above cleaner in terms of the components, their ratios, etc., except for its use in which the antifoulant is applied to an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) outside a living body. Therefore, the above description of the components, their ratios, etc, regarding the cleaner can be applied to the antifoulant, by replacing the terms “cleaner” and “cleaning” with the terms “antifoulant” and “antifouling”, respectively.
- the application of the antifoulant can be done by any method as long as the antifoulant is applied to or allowed to adhere to an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)).
- Examples of the method include coating, spraying and immersion, but are not limited thereto.
- Table 1 the unit of the numerical values in the formulas is gram (g). The same is applied to Tables 2 to 6.
- Purified water in an amount of 100 g was used as a cleaner.
- Purified water in an amount of 100 g was used as a cleaner.
- Test Example 3 The results of Test Example 3 are shown in FIG. 3 .
- Comparative Example 7 hardly removed the debris whereas all of the cleaners of Examples 27 to 30 showed high debris removal rates of 70% or more.
- Purified water in an amount of 100 g was used as a cleaner.
- Test Example 4 The results of Test Example 4 are shown in FIG. 4 .
- Purified water in an amount of 100 g was used as a cleaner.
- Example 33 On a glass slide, a drop of 50 ⁇ L of the cleaner (25 ⁇ 1° C.) obtained, in Example 33, Example 33, or Comparative Example 9 is placed, and spread over the entire surface. 2) The glass slide of the above 1) is held horizontal at 5° C./ambient humidity for 10 minutes. 3) The glass slide is transferred into a thermostatic chamber at 40° C./75% RH and held horizontal for 2 minutes. 4) Immediately after taking the glass slide out of the thermostatic chamber, the antifogging effect is evaluated at room temperature/ambient humidity and expressed as Good, Fair, or Poor.
- Test Example 5 The results of Test Example 5 are shown in FIG. 5 .
- Examples 33 and 34 showed high antifogging effect.
- antifouling treatment was given to an endoscope lens.
- the anti fouling treatment was performed by applying the antifoulant to the surface of the endoscope lens with a cotton swab.
- ESD endoscopic submucosal dissection
- Grade 0 no debris was observed on the endoscope lens, or debris was perfectly removed by washing the lens inside the colon and rectum with water injected from the forceps channel or water delivered by the endoscope system (level 0 in FIG. 6 ).
- Grade 1 debris was not perfectly removed by the above-described washing with water but did not result in severely blurred endoscopic view (level 1 in FIG. 6 ).
- Grade 2 debris was not perfectly removed by the above-described washing with water and ESD could not be continued due to severely blurred endoscopic view (level 2 in FIG. 6 ).
- Grade 0 no fat in the adipose tissue (level 0 in FIG. 7 ).
- Grade 1 a small amount of fat in the adipose tissue (level 1 in FIG. 7 ).
- Grade 2 a large amount of fat in the adipose tissue, which made the dissection difficult to carry out (level 2 in FIG. 7 ).
- ESD was performed using an endoscope that was subjected to antifouling in the same manner as in Example 30 except for using, instead of the cleaner of Example 15, a commercially available endoscopic antifogging agent for use in natural orifice (“SL cleaner” made by Sugiura Laboratory, Inc.; components: linear alkylbenzene sulfonate (anionic surfactant), polyoxyethylene alkyl ether, and ethanol). Endoscopic images obtained during and after the submucosal dissection were observed and evaluated.
- SL cleaner endoscopic antifogging agent for use in natural orifice
- the antifouling treatment successfully reduced the accumulation of debris on the endoscope lens after the ESD of the patients.
- the amount of fat in the submucosal adipose tissue in the patients was similar (not significant (NS)) between Example 35 and Example 36, but Example 35 using the antifoulant containing the specific surfactants as antifouling components significantly reduced the accumulation of debris on the endoscope lens compared with Example 36 using the commercially available endoscopic antifoulant for use in natural orifice.
- Example 36 From the patients in Example 36, five cases determined as Grade 1 and five cases determined as Grade 2 in terms of the accumulation of debris after submucosal dissection were selected, and the cleaning effect of the cleaner of Example 15 on an endoscope lens (and an endoscope hood (attachment)) was further evaluated inside the bodies of these patients.
- the cleaning was performed as follows. The distal end of the endoscope was deflected upward with its face up, and the cleaner of Example 15 was injected from the forceps channel so that the cleaner was kept in the endoscope hood (attachment) for 30 seconds (i.e., the endoscope lens was kept immersed in the cleaner for 30 seconds).
- the present invention provides a cleaner for an endoscope, the cleaner being used inside a living body during an endoscopic surgical procedure.
- the cleaner of the present invention can be used to clean debris from an endoscope lens and/or an endoscope hood (attachment) inside a living body, which feature greatly reduces the burden on a physician and the patient during an endoscopic surgical procedure.
- the cleaner of the present invention improves the antifogging properties of an endoscope lens and/or an endoscope hood (attachment), and thereby increases the usability of an endoscopic surgical procedure.
- the present invention also provides an antifoulant to be used for an endoscope lens and/or an endoscope hood (attachment) before an endoscopic surgical procedure.
- the antifoulant reduces or prevents the accumulation of debris on the endoscope lens and/or the endoscope hood (attachment).
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Abstract
Description
- The present invention relates to a cleaner for cleaning various types of medical endoscopes, including laryngoscopes, bronchoscopes, upper gastrointestinal endoscopes, lower gastrointestinal endoscopes, duodenoscopes, enteroscopes, colonoscopes, capsule endoscopes, thoracoscopes, laparoscopes, cystoscopes, cholangioscopes, arthroscopes, spinal endoscopes, angioscopes, epiduroscopes, magnifying endoscopes, ultrasonic endoscopes, side-viewing endoscopes, oblique-viewing endoscopes, etc. In particular, the present invention relates to a cleaner for cleaning such various types of endoscopes inside a living body during a surgical procedure.
- The present invention also relates to an antifoulant useful for antifouling treatment of such an endoscope before use.
- With today's highly advanced medical techniques, various organs in a human body can be diagnosed and treated using a medical endoscope without making large surgical incision. Endoscopic diagnosis and treatment are applied to, for example, nasal cavity, pharynx, larynx, esophagus, trachea, bronchus, upper and lower gastrointestinal tract, thorax, abdominal cavity, renal pelvis and ureter, bile duct, joints, spine, blood vessels, subdural space, etc. However, during endoscopic diagnostic and therapeutic procedures of these organs, debris composed of blood, body fluid, gastric juice, saliva and cell debris as well as of fatty tissue released by resection of the affected site accumulates on the lens and results in a blurred endoscopic view, which often becomes obstacles to carry out diagnosis and treatment.
- The above problem is currently addressed by rinsing the lens with purified water from the endoscope system or an alternative means, but such, a method is not effective enough for obtaining a clear endoscopic view. Accordingly, a physician has to stop the procedure to withdraw the endoscope outside the body for wiping the debris from the lens, and then reinsert line endscope into the body to continue the diagnostic or therapeutic procedure. However, withdrawing the endoscope greatly increases the burden on the physician and the patient.
- Cleaning of a medical endoscope is often performed, using a pH-neutral dish detergent or a cleaner containing a zwitterionic surfactant such as aminoethyl glycine hydrochloride. Some medical facilities use so-called electrolytic water (alkaline water, acidic water or weakly acidic water) produced by electrolysis of sodium chloride solution. As examples of other types of cleaners,
Patent Literature 1 discloses a cleaner for an endoscope, comprising a nonionic surfactant and an enzyme, andPatent Literature 2 discloses a cleaning composition for medical devices, comprising a nonionic polymer, a nonionic surfactant, ethylenediaminetetraacetic acid and monoethanolamine. However, the cleaning ability of these cleaners is not effective enough for removing the debris from the lens. - Furthermore, most of cleaners with relatively strong cleaning ability are harmful to a living body. Residual-cleaners on an endoscope after cleaning is not desirable even in a small amount. Moreover, such cleaners cannot be used to clean an endoscope inside a living body during a surgical procedure. Therefore there has been a demand for the development of an endoscope lens cleaner with high cleaning ability and high safety for use inside a living body.
- An endoscope hood is sometimes attached to ensure a clear endoscopic view. An endoscope hood (attachment) is a cap to be attached to the distal end of an endoscope. An endoscope hood has regained attention as a necessary tool for magnification endoscopy and therapeutic endoscopy, which have recently been widely performed. Such an endoscope hood (attachment) also suffers from, the same problem as an endoscope lens. That is, debris composed of blood, body fluid, gastric juice, saliva and cell debris as well as of fatty tissue released by resection of the affected site accumulates on the hood and results in a blurred endoscopic view. Therefore, there has also been a demand for the development of an endoscope hood cleaner with high cleaning ability and high safety for use inside a living body.
- Patent Literature 1: JP 2001-031999 A
- Patent Literature 2: JP 2009-144070 A
- The present invention was made in view of the above problems, An object of the present invention is therefore to reduce the burden on a physician and the patient in endoscopic diagnosis and treatment and to provide a cleaner to be used inside a living body during an endoscopic surgical procedure. Another object of the present invention is to provide a cleaner with a high ability to clean debris from an endoscope lens and/or an endoscope hood (attachment). A further object of the present invention is to provide an antifoulant useful for antifouling treatment of an endoscope and/or endoscopic accessories, such as an endoscope lens and/or an endoscope hood (attachment).
- The inventors conducted extensive research to solve the above problems, and as a result found that a cleaner produced from particular cleaning components than are highly safe to a living body exhibits high cleaning effect on debris accumulated on an endoscope lens and/or an endoscope hood (attachment). Surprisingly, the inventors also found that a cleaner with, such components exhibits an excellent ability to prevent fouling of an endoscope lens and/or an endoscope hood (attachment) and that the cleaner thus can also be used as an antifoulant. The inventors made further study and completed the present invention.
- That is, the present invention relates to the following.
- (1) A cleaner for an endoscope, the cleaner being used inside a living body during an endoscopic surgical procedure.
(2) The cleaner of the above (1), comprising a surfactant.
(3) The cleaner of the above (1), comprising no surfactant.
(4) The cleaner of any one of the above (1) to (3), for removal of debris from an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)).
(5) The cleaner of the above (2) to (4), comprising (i) a nonionic surfactant with an HLB of 1 to 11 and (ii) a nonionic surfactant with an HLB of 11 to 20.
(6) The cleaner of any one of the above (1) to (5), comprising at least one type of a detergent builder.
(7) The cleaner of the above (1) to (8), which is delivered from a water nozzle, a forceps channel or a water-jet nozzle of an endoscope. - The present invention also includes a method for cleaning an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) with the cleaner inside a living body during an endoscopic surgical procedure [or a method for cleaning an endoscope and/or endoscopic: accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) to remove accumulated debris thereon (for example, blood, body fluid, gastric juice, saliva, cell debris, fatty tissue, etc.)].
- The present invention also includes an antifoulant for antifouling treatment Of an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)). Unlike the above cleaner, the antifoulant is an agent (composition) that is applied to an endoscope or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) outside a living body before they are inserted into the body, thereby reducing or preventing the accumulation of debris on the endoscope or the endoscopic accessories inside the living body during an endoscopic surgical procedure.
- The components of the antifoulant may be the same as those contained in the above cleaner. The antifoulant may typically comprise (1) a nonionic surfactant with an HLE of 1 to 11 and (ii) a nonionic surfactant with an RLE of 11 to 20.
- The antifoulant may further comprise an antifoulant builder (such as the same components as those used as detergent builders, for example, sodium, hydrogen carbonate).
- The present invention also includes a method for subjecting an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) to antifouling treatment with the antifoulant for a method for reducing or preventing the accumulation of debris (for example, blood, body fluid, gastric juice, saliva, cell debris, fatty tissue, etc.) on an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) inside a living body during an endoscopic surgical procedure, the -method comprising subjecting the endoscope and/or the endoscopic accessories to antifouling treatment before the surgical procedure].
- The method may be combined with the above cleaning method. That is, the above methods may be a combined method comprising subjecting an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) to antifouling treatment with the antifoulant before use, and then cleaning the endoscope and/or the endoscopic accessories (in particular, the endoscope lens and/or the endoscope hood (attachment)) inside a living body during an endoscopic surgical procedure [or a method for preventing the accumulation of debris on an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) and removing debris inside a living body during an endoscopic surgical procedure, the method comprising cleaning the endoscope and/or the endoscopic accessories before and during the surgical procedure].
- The endoscopic surgical procedure in the present invention (in particular, in use of the: cleaner or the cleaning method, or the antifoulant or the antifouling treatment method) is not particularly limited, and may be, for example, endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD).
- ESD is a surgical operation for tumors located in sites inaccessible to resection by SMR or for large tumors. ESD requires longer hours of operation and is thus more susceptible to the accumulation of debris. Hence the present invention may be appropriately used in, in particular, ESD.
- The present invention provides a cleaner that is highly safe for use inside a living body so that the cleaner can be used inside a living body during an endoscopic surgical procedure. The cleaner of the present invention has a high ability to clean debris from an endoscope and/or endoscopic accessories (in particular, from an endoscope lens and/or an endoscope hood) and provides antifogging effect to an endoscope lens. The present invention also provides an antifoulant useful for antifouling treatment of an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) outside a living body before they are inserted into the body for an endoscopic surgical procedure. The antifoulant has excellent antifouling ability and reduces or prevents the accumulation of debris on an endoscope lens and/or an endoscope hood (attachment). The present invention greatly reduces the burden on a physician and the patient during an endoscopic surgical procedure.
-
FIG. 1 is a schematic view of the distal end (with a lens) of an endoscope. -
FIG. 2 is a schematic view of the endoscope distal end with an attached endoscope hood. -
FIG. 3 shows the results of Test Example 3 (cleaning effect on oil film on endoscope lenses). -
FIG. 4 shows the results of Test Example 4 (cleaning effect on oil film on endoscope hoods (attachments)). -
FIG. 5 shows the results of Test Example 5 (antifogging effect). -
FIG. 6 shows endoscopic photographs used as an indicator for the evaluation of debris accumulated on the endoscope lens after endoscopic submucosal dissection, -
FIG. 7 shows endoscopic photographs used as an indicator for the evaluation of the amount of fat in the submucosal adipose tissue, - The present invention will be described in detail below.
- The present invention relates to a cleaner for an endoscope, the cleaner being used inside a living body during an endoscopic surgical procedure. The term “endoscopic surgical procedure” herein includes any: types of diagnosis, treatment and prevention using an endoscope. The cleaner of the present invention comprises a cleaning component in such a manner that high safety for use inside a living body is ensured and that the cleaner exhibits a sufficient ability to clean debris from an endoscope lens and/or an endoscope hood (attachment). The cleaning component is not particularly limited, and the cleaner may comprise various types of known cleaning components. Such cleaning components can also be used as antifouling components as described later.
- The cleaner of the present invention may comprise a surfactant, but it is not essential.
- The cleaner of the present invention may comprise, if desired, one or more of a detergent builder (hereinafter also called a builder), a preservative, a solubilizing agent or an emulsifier, a viscosity modifier and an antioxidant.
- The builder is not particularly limited, and may be an inorganic builder or an organic builder.
- Specific examples of the inorganic builder include carbonates, sulfates, hydrochlorides, phosphates, and borates of alkali metals and alkaline earth metals and boric acid. More specific examples thereof include sodium hydroxide, sodium sulfate, magnesium sulfate, sodium chloride, magnesium chloride, carbonates (such as sodium carbonate), hydrogen carbonates (such as sodium hydrogen carbonate), phosphates (such as sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, dipotassium phosphate, and potassium dihydrogen phosphate), sodium tripolyphosphate, sodium pyrophosphate, potassium pyrophosphate, sodium hexametaphosphate, borax, boric acid, magnesium carbonate, calcium carbonate, and calcium sulfate. Of these, preferred are sodium hydrogen carbonate, sodium phosphate, sodium monohydrogen phosphate, and potassium dihydrogen phosphate due to their ability to increase the cleaning effect.
- Specific examples of the organic builder include carboxylic acids, hydroxycarboxylic acids, polycarboxylic acids, hydroxypolycarboxylic acids and salts thereof, and aminocarboxylic acids, aminopolycarboxylic acids, and salts thereof, each having 2 to 10 carbon atoms. More specific examples thereof include organic acids such as citric acid, malic acid, succinic acid, maleic acid, fumaric acid, gluconic acid and adipic acid and salts thereof and aminopolycarboxylic acids such as ethylenediaminetetraacetic acid and nitrilotriacetic acid and salts thereof. Examples of the organic builder further include sugars such as glucose, sucrose, fructose, and lactose; and ureas.
- In an embodiment of the present invention, these builders can be used alone or in combination of two or more of them. In addition to their roles as a detergent builder, the builders can also serve as a pH adjuster. The builders (detergent builders) can also be used as an antifouling component (or an antifoulant builder) as described later,
- The amount of the builder(s) contained in the cleaner is not particularly limited, and may be, for example, typically less than 3% by mass based on the total mass of the cleaner, and to sufficiently achieve the intended effects, the amount is preferably 0.01 to 0.6% by mass and more preferably 0.05 to 0.3% by mass.
- The preservative is not particularly limited and examples thereof include benzoic acid and salts thereof, salicylic acid and salts thereof, sorbic acid and salts thereof, denydroacetic acid and salts thereof, p-hydroxybenzoic acid esters such as p-hydroxybenzoic acid alkyl esters (e.g., methylparaben, ethylparaben, propylparaben, butylparaben, etc.), 2, 4,4′-trichloro-2′-hydroxydiphenyl ether, 3,3,4′-trichlorocarbanilide, hexachlorophene, benzalkonium, chloride, phenoxyethanol, hinokitiol, resorcin, ethanol, 1,3-butylene glycol, isopropylrnethylphenol, and polyhydric alcohols such as 1,3-botylene glycol, 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol, Examples of the salts include sodium salts, potassium salts, magnesium salts, calcium salts, and ammonium salts. Of the above preservatives, methylparaben, propylparaben, ethanol, etc. are preferred in view of safety to a living body.
- The solubilizing agent or the emulsifier is not particularly limited and examples thereof include dimethylisosorbide, transcutol, ethyl alcohol, isopropyl alcohol, polyethylene glycol, propylene glycol, castor oil, isopropyl, myristate, octyldodecanol, isocetyl alcohol, oleyl alcohol, oleyl cetyl alcohol; triglycerides of medium-chain fatty acids derived from plants, such as caprylic triglyceride and capric triglyceride, Miglyols(R), which is a mixture of propylene glycol dicaprylate and propylene glycol dicaprate, Neobee M-5, which is a mixture of caprylic triglyceride and capric triglyceride; polysorbates such as polysorbate 20, polysorbate 40, polysorbate 60, and polysorbate 80; sorbitans such as sorbitan laurate, sorbitan oleate, sorbitan palmitate, sorbitan stearate, sorbitan trioleate, and sorbitan tristearate; glyceryl monostearate, polyoxyethylene stearate, polyoxyethylene lauryl ether, PEG-20 glyceryl stearate, ceteareth-12, ceteareth-20, ceteareth-30, PFG-2-ceteareth-5; polyethylene glycol ethers of oleyl alcohol, such as oleth-5, oleth-10, and a mixture of oleth-5 and oleth-10; stearols such as soya stearol, PSG-5 soya stearol, PEG-10 stearol, PEG-16 soya stearol, and PEG-25 soya stearol; sodium stearyl sulfate, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, and polyoxyethylene (160) polyoxypropylene (30) glycol. These solubilizing agents or emulsifiers may be used alone or in combination of two or more of them.
- The viscosity modifier is not particularly limited and examples thereof include cetyl alcohol, stearyl alcohol, cetyl stearyl alcohol, myristyl alcohol, xanthan gum, VEEGUM (magnesium, aluminum silicate), carbomer, glyceryl stearate, hydrogenated castor oil, cetyl palmitate, stearic acid, a combination of synthetic and semisynthetic wax, a combination of glyceryl stearate, stearyl alcohol, cetyl palmitate, and cocoglycerides blend, and a combination of glyceryl, hydroxystearate, cetyl palmitate, and trihydroxystearin blend. These viscosity modifiers may be used alone or in combination of two or more of them.
- The antioxidant used in the present invention is not particularly limited and examples thereof include ascorbic acid, phosphate derivatives of ascorbic acid, and salts thereof, stearic acid esters, tocopherol and derivatives thereof, butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), hydroxytyrosol, p-hydroxyanisole, propyl gallate, sesamol sesamolin, and gossypol.
- The solvent used for the production of the cleaner of the present invention is not particularly limited and examples thereof include water, and lower alcohols, ether alcohols, glycols and ketones, each of which has 1 to 6 carbon atoms, such as methane), ethanol, propanol, isopropyl alcohol, ethylene glycol, propylene glycol, diethylene glycol, methyl glycol, ethyl glycol, butyl glycol, glycerol, concentrated glycerol, acetone, and methyl ethyl ketone. The water may be tap water, purified water, sterile purified water, or sterile water. Of these solvents, water, in particular, purified water, sterile purified water, and sterile water are preferred in view of safety to a living body.
- The pH of the cleaner of the present invention is not particularly limited, and may be, for example, typically 3 to 12, and is preferably 4 to 10 and more preferably 6 to 9, in view of safety to a living body and in order to enhance the cleaning effect.
- The viscosity of the cleaner of the present invention is not particularly limited, and may be, for example, typically 1 to 500 mPa·s, and is preferably 1 to 200 mPa·s in view of clinical convenience.
- One embodiment, of the present invention relates to the cleaner comprising a surfactant as a cleaning component. The surfactant used in the present invention may he any surfactant as long as the effects of the present invention are achieved. The surfactant may be, for example, a combination of nonionic surfactants with different HLBs values.
- The hydrophile-lipophile balance (HLB) herein is an index indicating the hydrophilicity of a nonionic surfactant.
- The HLB value can he calculated by any of the following formulas:
-
[(molecular weight of hydrophilic group moieties/molecular weight of surfactant)×100/5], -
[(weight of hydrophilic groups/(weight ofhydrophobic groups 4−weight of hydrophilic groups))×100/5], or -
((percent by weight of hydrophilic groups)×1/5). - The HLB value ranges from 0 to 20, and an HLB value closer to 20 indicates higher hydrophilicity.
- In a preferred embodiment of the present invention, the cleaner comprises (i) a nonionic surfactant with an HLB of 1 to 11 and (ii) a nonionic surfactant with an HLB of 11 to 20 (for example, 12 to 19, preferably 13 to 18).
- The nonionic surfactant (i) is not particularly limited and examples thereof include the following (the numbers in the brackets ([ ])) represent the HLB values): monoglyceride [2.6 to 3,5], sorbitan monocaprylate [9, 6], sorbitan monolaurate [8.6], sorbitan monopalmitate [6.7], sorbitan monostearate [4.7], sorbitan monooleate [4.3], sorbitan trioleate [1.8], sorbitan trioleate with 20 mol EO [11.0], sorbitan monooleate with 5-mol EO [10.0], sorbitan monostearate with 4 mol EO [9.6], polysorbate 65 [10.5], polyethylene glycol (200) monolaurate [9.8], polyethylene glycol (200) monostearate [8.5], polyethylene glycol (200) monooleate [8.4], polyethylene glycol (200) dilaurate [6.6], polyethylene glycol (400) dilaurate [9.8], polyethylene glycol (200) distearate [5.4], polyethylene, glycol (400) distearate [8.5], polyethylene glycol (200) dioleate [5.3], polyethylene glycol (400) dioleate [8.4], polyethylene -glycol (600) distearate [10.5], polyethylene glycol (600) dioleate [10.4], oleyl alcohol with 2 mol EO [4.9], whale alcohol with 5 mol EO [9.3], whale alcohol with 7 mol EO [10.8], nonylphenol with 4 mol EO [8.9], nonylphenol with 6 mol EO [10.9], lauryl alcohol with 5 mol EO [10.8], diglycerol monocaprylate [8.7], tetraglycerol monooleate [8.8], tetraglycerol monolaurate [10.3], sucrose stearate [1 to 11], sucrose laurate [1 to 5], and sucrose behenate [3]. These surfactants may be used alone or in combination of two or more of them. Of these surfactants, in view of safety to a living body, preferred are diglycerol monocaprylate [8.7], tetraglycerol monooleate [8.8], tetraglycerol monolaurate [10.3], sucrose stearate [1 to 1.11], sucrose laurate [1 to 5], sucrose behenate [3], etc.
- The nonionic surfactant (ii) is not particularly limited and examples thereof include the following: sorbitan monolaurate with 4 mol EO [13.3], sorbitan monolaurate with 20 mol EO [16.7], sorbitan monopalmitate with 20 mol EO [15.6], sorbitan monostearate with 20 mol EO [14.9], sorbitan monooleate with 20 mol EO [15.0], polysorbate 20 [16.0 to 16.9], polysorbate 40 [15.6 to 16.0], polysorbate 60 [14.9 to 15.7], polysorbate 80 [15.0 to 15.7], polyethylene glycol (400) monolaurate [13.1], polyethylene glycol (600) monolaurate [14.8], polyethylene glycol (1000) monolaurate [16.5], polyethylene glycol (400) monostearate [11.9], polyethylene glycol (600) monostearate [13.8], polyethylene glycol (1000) monostearate [15.8], polyethylene glycol (400) monooleate [11.8], polyethylene glycol (600) monooleate [13.7], polyethylene glycol (1000) monooleate [15.7], polyethylene glycol (600) dilaurate [11.8], polyethylene glycol (1000) dilaurate [14.1], polyethylene glycol (1540) dilaurate [15.7], polyethylene glycol (1000) distearate [13.0], polyethylene glycol (1540) distearate [14.8], polyethylene glycol (1000) dioleate [12.9], polyethylene glycol (1540) dioleate [14.7], lauryl alcohol with 10 mol EO [14.1], lauryl alcohol with 23 mol EO [16.0], oleyl alcohol with 10 mol EO [12.4], oleyl alcohol with 20 mol EO [15.3], whale alcohol with 11 mol EO [13.2], whale alcohol with 14 mol EO [14.2], whale alcohol with 18 mol EO [15.1], whale alcohol with 24 mol EO [16.1], nonylphenol with 7 mol EO [11.7], nonylphenol with 10 mol EO [13.3], nonylphenol with 12 mol EO [14.1], nonylphenol with 14 mol EO [14.8], nonylphenol with 16 mol EO [15.2], nonylphenol with 20 mol EO [16.0], nonylphenol with 40 mol EO [17.8], decaglycerol monocaprylate [16.0], decaglycerol monolaurate [14.8], hexaglycerol monooleate [11.6], decaglycerol monolaurate [15.6], decaglycerol monomyristate [14.6], sucrose stearate [15 to 16], sucrose palmitate [15 to 16], sucrose myristate [16], sucrose oleate [15], and sucrose laurate [16]. These surfactants may be used alone or in combination of two or more of them. Of these surfactants, in view of safety to a living body, preferred are decaglycerol monocaprylate [16.0], decaglycerol monolaurate [14.8], hexaglycerol monooleate [11.6], decaglycerol monolaurate [15.6], decaglycerol monomyristate [14.6], sucrose stearate [15 to 16], sucrose palmitate [15 to 16], sucrose myristate [16], sucrose oleate [15], sucrose laurate [about 16], etc.
- Herein EO represents ethylene oxide.
- In a preferred embodiment of the present invention, the total amount of the nonionic surfactants contained in the cleaner is typically 0.1 to 40% by mass, preferably 1 to 35% by mass, more preferably 3 to 30% by mass, and particularly preferably 5% by mass or more (for example, 5 to 40% by mass, preferably 6 to 35% by mass, and further more preferably 7 to 30% by mass), based on the total weight of the cleaner. The cleaner containing the nonionic surfactants in such a total amount exhibits a sufficient cleaning effect and is sufficiently safe for use inside a living body.
- The total amount of the surfactants may be appropriately selected depending on the combination of the surfactants to be used.
- In another preferred embodiment of the present invention, the ratio of the nonionic surfactants (i):(ii) contained in the cleaner is, in terms of mass, typically 2:1 to 1:10, preferably 1:1 to 1:9, and more preferably 1:2 to 1:7. The cleaner containing the surfactants in such a ratio exhibits high cleaning effect.
- in another preferred embodiment of the present invention, the combined HLB value of the nonionic surfactants (i) and (ii) is typically 11.1 to 16.0, preferably 13.0 to 15.5, and more preferably 13.6 to 15.3. The cleaner containing the surfactants with such a combined HLB value exhibits high cleaning effect.
- Particularly preferably, the nonionic surfactants (i) and (ii) contained in the cleaner of the present invention has a combined HLB value of 13.6 to 15.3, a mass ratio (i):(ii) of 1:2 to 1:7, and a total amount of 3 to 30% by mass based on the total amount of the cleaner.
- In a preferred embodiment of the present invention, it is preferred that the nonionic surfactant (i) is at least one type selected from the group consisting of diglycerol monocaprylate, tetraglycerol monooleate, and tetraglycerol monolaurate, and that the nonionic surfactant (ii) is at least one type selected from the group consisting of decaglycerol monocaprylate, decaglycerol monolaurate, hexaglycerol monooleate, decaglycerol monolaurate, and decaglycerol monomyristate.
- The cleaner of the present invention comprising the surfactant (a) as a cleaning component may comprise, if desired, a builder, a preservative, a solubilizing agent or an emulsifier, a viscosity modifier, an antioxidant, a defoaming agent, etc. The builder, the preservative, the solubilizing agent or the emulsifier, the viscosity modifier, and the antioxidant may be the same as those described above. The solvent to be used and the viscosity and pH of the cleaner may also be the same as those described above.
- The ratio of the detergent builder (for example, an inorganic builder such as sodium hydrogen carbonate) relative to 100 parts by mass of the surfactant(s) may be selected from the range of, for example, about 0,01 to 100 parts by mass (for example, about 0.03 to 50 parts by mass), and is preferably about 0.05 to 30 parts by mass, more preferably about 0.1 to 20 parts by mass, and particularly preferably about 0.5 to 20 parts by mass (for example, about 1 to 10 parts by mass).
- The defoaming agent is not particularly limited and examples thereof include alcohols (such as methanol, ethanol, 1 -propanol, 2-propanol, lauryl alcohol, and stearyl alcohol) and silicone compounds (such as dimethyl silicone, fluorosilicone, and polyether silicone). Of these defoaming agents, dimethyl silicone is preferred due to its defoaming performance and in view of safety to a living body.
- Another embodiment of the present invention relates to the cleaner comprising no surfactant. In this embodiment, the components in the cleaner of the present invention are not particularly limited, and the cleaner may comprise, as a cleaning component, for example, an inorganic compound such as a carbonate, a sulfate, a hydrochloride, a phosphate or a borate of an alkali metal or an alkaline earth metal, or boric acid; or an organic compound such as a carboxylic acid, a hydroxycarboxylic acid, a polycarboxylic acid or a hydroxypolycarboxylic acid, or a salt thereof, or an aminocarboxylic acid or an aminopolycarboxylic acid, or a salt thereof, each having 2 to 10 carbon atoms.
- The inorganic compound used as a cleaning component is not particularly limited and specific examples thereof include sodium sulfate, magnesium sulfate, sodium chloride, magnesium chloride, sodium carbonate, sodium hydrogen carbonate, sodium phosphate, sodium monohydrogen phosphate, sodium dihydrogen phosphate, sodium tripolyphosphate, sodium pyrophosphate, potassium pyrophosphate, sodium hexametaphosphate, borax, boric acid, magnesium carbonate, calcium carbonate, and calcium sulfate.
- The organic compound used as a cleaning component is not particularly limited and specific examples thereof include carboxylic acids, hydroxycarboxylic acids, polycarboxylic acids, hydroxypolycarboxylic acids and salts thereof, and aminocarboxylic acids, aminopolycarboxylic acids, and salts thereof, each having 2 to 10 carbon atoms. More specific examples thereof include organic acids such as citric acid, malic acid, succinic acid, maleic acid, fumaric acid, gluconic acid and adipic acid and salts thereof; and aminopolycarboxylic acids such as ethylenediaminetetraacetic acid and nitrilotriacetic acid and salts thereof. Examples of the organic compound further include sugars such as glucose, sucrose, fructose, and lactose; and ureas.
- In the cleaner of the present invention comprising no surfactant, the above cleaning components may be used alone or in combination of two or more of them. In order to enhance the cleaning effect, two or more of the cleaning components are preferably used in combination. The combination of the cleaning components is not particularly limited and examples of thereof include a combination of sodium hydrogen carbonate and sodium hexametaphosphate and a combination of sodium hydrogen carbonate and sodium citrate. In the present invention, such a combination of the cleaning components may be used together with a surfactant.
- In this embodiment, the total amount of the cleaning components contained in the cleaner is not particularly limited and may be, for example, 0.01 to 10% by mass based on the total amount of the cleaner of the present invention.
- In cases where two or more of the cleaning components are used in combination, the blending ratio may be any ratio as long as the cleaning effect is sufficiently achieved, in cases where, for example, two types of the cleaning components are used in combination, the blending ratio in terms of mass may be 1:1 to 1:5.
- In cases where the cleaner of the present invention comprises no surfactant, the cleaning component(s) preferably also serves as a buffering agent.
- The cleaner of the present invention comprising no surfactant may further comprise, if desired, an alkali for the purpose of adjusting the pH. Examples of the alkali include sodium hydroxide, potassium hydroxide, lithium hydroxide, sodium carbonate, potassium carbonate, ammonium carbonate, and a combination thereof.
- The cleaner of the present invention comprising no surfactant may comprise, if desired, a builder, a preservative, a solubilizing agent or an emulsifier, a viscosity modifier, an antioxidant, etc. The builder, the preservative, the solubilizing agent or the emulsifier, the viscosity modifier and the antioxidant may be the same as those described above. The solvent to be used and the viscosity and pH of the cleaner may also be the same as those described above.
- Preferably, the cleaner of the present invention comprising no surfactant hardly foams during cleaning even without the addition of a defoaming agent.
- The cleaner of the present invention (comprising or not comprising a surfactant) is suitable for the removal of debris accumulated on an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) inside a living body during an endoscopic surgical procedure. The delivery of the cleaner for the removal of debris from an endoscope lens can be done by any means, including, for example, an air/water nozzle (hereinafter simply called, “a water nozzle”, see numeral 5 in
FIG. 1 ), a forceps channel (see numeral 3 inFIG. 1 ), a water-jet nozzle (seenumeral 4 ofFIG. 1 ), etc. of an endoscope. The delivery means may be appropriately selected depending on the purpose. - The endoscope hood (attachment) in the present invention is not particularly limited, and may be, for example, an attachment that is attached to an endoscope as shown in
numeral 6 of the schematic view inFIG. 2 . The material, color, shape, etc. of the endoscope hood may be appropriately selected as desired. Specific examples of the endoscope hood (attachment) include slit & hole type or straight type of Elastic Touch (registered trademark) made by Top Corporation; various types of hoods of Mole Cap (registered trademark) made by Top Corporation; etc. - In an embodiment of the present invention where a hood is attached to an endoscope, the removal of debris from the endoscope lens and the endoscope hood (attachment) is preferably done by, for example, spraying the cleaner on the endoscope hood (attachment) from a spray nozzle etc. inserted through the forceps channel. The spray nozzle is not particularly limited, and specific examples thereof include the spray nozzle of Fine Jet (registered trademark) made by Top Corporation, etc. More preferably, the removal of debris is done by, for example, deflecting the distal end upward with its face up and injecting the cleaner from the forceps channel so that the cleaner is kept in the endoscope hood (attachment) (i.e., the endoscope lens is kept immersed in the cleaner); or pressing the edge of the endoscope hood (attachment) against the inner wall of a cavity of a living body and injecting the cleaner so that the hood is filled with the cleaner. In this embodiment, the cleaner kept in the hood may be stirred with, for example, a stirring stick etc. inserted through the forceps channel.
- In addition to the cleaning function, the cleaner of the present invention after used to remove the debris from an endoscope lens and/or an endoscope hood (attachment) also exhibits a function of providing antifogging effect to the endoscope lens and/or the endoscope hood (attachment).
- With the use of the cleaner of the present invention, a physician can remove debris from an endoscope lens and/or an endoscope hood (attachment) during a surgical procedure without withdrawing the endoscope outside the body. The physician does not need to stop the procedure, and consequently the burden on the physician and the patient is greatly reduced.
- The cleaner (or its components) of the present invention can also be used as an antifoulant (a surface treating agent, an antifouling treatment agent, or a surface protective agent) for an endoscope and/or endoscopic accessories (or endoscope attachments), in particular, for an endoscope lens and/or an endoscope hood (attachment).
- That is, an endoscope lens and/or an endoscope hood, etc. may be subjected to antifouling treatment using the cleaner (or its components) as an antifoulant [i.e., antifouling treatment in which, for example, the cleaner is applied to an endoscope lens and/or an endoscope hood (or the cleaner is allowed to adhere thereto)] outside a living body before the endoscope is inserted into the body. This antifouling treatment reduces or prevents the accumulation of various debris components (for example, fat etc.) on the endoscope lens and/or the endoscope hood (attachment), etc. inside the living body during an endoscopic surgical procedure.
- The antifoulant can also provide antifogging effect to an endoscope lens and/or an endoscope hood (attachment), etc. Therefore, the antifoulant of the present invention can also be used as an antifogging agent (an antifouling and antifogging agent).
- The components of the antifoulant may be the same as those of the above cleaner, and their content ratios are the same as described above. Among the above-described cleaning components, a surfactant is particularly suitable as an antifouling component.
- The antifoulant may comprise, as an antifouling component, the above-described surfactant, for example, a surfactant combination of (i) a nonionic surfactant with an HLB of 1 to 11 and (ii) a nonionic surfactant with an HLB of 11 to 20 (for example, 12 to 19, preferably 13 to 18). The total amount of the nonionic surfactants may be typically 0.1 to 40% by mass, and is preferably 1 to 35% by mass, more preferably 3 to 30% by mass, and particularly preferably 5% by mass or more (for example, 5 to 40% by mass, preferably 6 to 35% by mass, and further more preferably 7 to 30% by mass), based on the total weight of the antifoulant.
- The ratio of the nonionic surfactants (i):(ii) contained in the antifoulant may be, in terms of mass, typically 2:1 to 1:10, preferably 1:1 to 1:9, more preferably 1:2 to 1:7. The combined HLB value of the nonionic surfactants (i) and (ii) may be typically 11.1 to 16.0, and is preferably 13.0 to 15.5, and more preferably 13.6 to 15.3. The nonionic surfactants (i) and (ii) contained in the antifoulant of the present invention may have a combined HLB value of 13.6 to 15.3, a mass ratio of 1:2 to 1:7, and a total amount of 3 to 30% by mass based on the total amount of the cleaner.
- The antifoulant may comprise the above-described builder (sodium hydrogen carbonate etc.) as an antifoulant builder. In this case, the ratio of the antifoulant builder relative to 100 parts by mass of the surfactant(s) can be selected from the range of about 0.01 to 100 parts by mass (for example, about 0.03 to 50 parts by mass), and is preferably about 0.05 to 30 parts by-mass, more preferably about 0.1 to 20 parts by mass, and in particular may be about 0.5 to 20 parts by mass (for example, about 1 to 10 parts by mass).
- That is, the antifoulant of the present invention may be the same as the above cleaner in terms of the components, their ratios, etc., except for its use in which the antifoulant is applied to an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)) outside a living body. Therefore, the above description of the components, their ratios, etc, regarding the cleaner can be applied to the antifoulant, by replacing the terms “cleaner” and “cleaning” with the terms “antifoulant” and “antifouling”, respectively.
- The application of the antifoulant (antifouling treatment) can be done by any method as long as the antifoulant is applied to or allowed to adhere to an endoscope and/or endoscopic accessories (in particular, an endoscope lens and/or an endoscope hood (attachment)). Examples of the method include coating, spraying and immersion, but are not limited thereto.
- Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples, but is not limited thereto. Various modifications can be made within the technical idea of the present invention by those who have ordinary skill in the art.
- To purified water were added diglycerol monocaprylate, tetraglycerol monolaurate and/or decaglycerol monocaprylate according to the formulas in Table 1. The mixture was heated to 80° C. in a water bath while stirred with a stirrer. After the dissolution, the solution was cooled to 40° C. or less, then sodium hydrogen carbonate was added, and the mixture was stirred until sodium hydrogen carbonate was dissolved. After the dissolution, the solution was cooled to 30° C. or less, then a silicone resin emulsion (defoaming agent) previously diluted five-fold with purified water was added, and the mixture was stirred until the silicone resin emulsion was uniformly dissolved. Purified water was finally added to a total amount of 100 g to give a cleaner.
- In Table 1, the unit of the numerical values in the formulas is gram (g). The same is applied to Tables 2 to 6.
- To purified water were added sodium hydrogen carbonate and/or trisodium citrate dihydrate according to the formulas in Table 2, and the mixture was thoroughly stirred to give a cleaner.
- Purified water in an amount of 100 g was used as a cleaner.
- To purified water were added diglycerol monocaprylate, decaglycerol monocaprylate and/or polysorbate 80 according to the formulas in Table 3. The mixture was heated to 80° C. in a water bath while stirred with a stirrer. After the dissolution, the solution was allowed to cool down to room temperature. Purified water was added to a total amount of 100 g to give a cleaner.
- 1) Fatty tissue from a resected porcine stomach model is melted by heating, and 20 g of the obtained oil and 0.1 g of Oil Red are dissolved in 60 mL of chloroform.
2) In the oil film model solution of the above 1), glass slides are immersed for 2 seconds (the slides are divided into sets of three).
3) The slides are left at room temperature for 1 to 2 hours for drying and solidifying the oil, and then weighed (the amount of adhering oil: 14±2 mg).
4) In separate beakers, 70 ml of each of the cleaners, at 25±1° C., obtained in Examples 1 to 26 and Comparative Examples 1 to 6 is placed.
5) In the beakers of the above 2), the glass slides with the oil film formed in the above 3) are immersed for 1 minute.
6) In another beaker containing 75 mL of water, the glass slides are immersed for 1 minute with shaking (100 rpm).
7) After natural drying, the sets of the three slides are immersed in chloroform for dissolution of the oil film. The volume is adjusted to 50 mL, and the absorbance is determined for the calculation of a cleaning rate. -
Cleaning rate (%)=(absorbance after washed with purified water)/(absorbance after washed with cleaner)×100 - Into separate vials, 50 mL of each of the cleaners obtained in Examples 1 to 26 and Comparative Examples 2 to 6 was poured. After sealing, the vials were stored at 5° C. or 40° C. for one month.
- Good: clear homogeneous liquid without separation or precipitation.
- Fair: cloudy homogeneous liquid without separation or precipitation.
- Poor: inhomogeneous liquid with complete separation or precipitation.
- The results of Test Examples 1 and 2 are shown in Tables 1 to 3.
- All the cleaners of the Examples showed higher cleaning rates as compared with the cleaners of Comparative Examples 1 to 6. In particular, the cleaners of Examples 7 to 15 and Examples 17 to 26 showed excellent one-month storage stability at 5° C. and 40° C.
-
TABLE 1 Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Component Substance HLB 1 2 3 4 5 6 7 8 9 Cleaner (nonionic Diglycerol monocaprylate 8.7 0.25 0.5 1 2 3 3 3 3 3 surfactant) Tetraglycerol monolaurate 10.3 Decaglycerol monocaprylate 16.0 0.5 1 2 4 3 6 9 12 15 Solubilizing agent Polysorbate 80 15.7 Alkali metal salt or Sodium hydrogen carbonate — alkaline earth metal salt Trisodium citrate dihydrate — Defoaming agent Silicone resin emulsion — Solvent Purified water — (q.s.) (q.s.) (q.s.) (q.s.) (q.s.) (q.s.) (q.s.) (q.s.) (q.s.) Combined HLB of surfactants 13.6 13.6 13.6 13.6 12.4 13.6 14.2 14.5 14.8 Cleaning rate (%) 132 133 121 170 124 328 319 435 381 Stability (one month) 5° C. Poor Fair Fair Good Good Good Good Good Good 40° C. Poor Fair Fair Poor Poor Fair Good Good Good Ex. Ex. Ex. Ex. Ex. Ex. Ex. Component Substance HLB 10 11 12 13 14 15 16 Cleaner (nonionic Diglycerol monocaprylate 8.7 3 3 1 1 2 2 surfactant) Tetraglycerol monolaurate 10.3 7 Decaglycerol monocaprylate 16.0 21 27 7 7 14 14 14 Solubilizing agent Polysorbate 80 15.7 Alkali metal salt or Sodium hydrogen carbonate — 0.1 0.2 0.2 alkaline earth metal salt Trisodium citrate dihydrate — Defoaming agent Silicone resin emulsion — 0.015 Solvent Purified water — (q.s.) (q.s.) (q.s.) (q.s.) (q.s.) (q.s.) (q.s.) Combined HLB of surfactants 15.1 15.3 15.1 15.1 15.1 16.0 14.1 Cleaning rate (%) 207 169 169 435 183 216 479 Stability (one month) 5° C. Good Good Good Good Good Good Poor 40° C. Good Good Good Good Good Good Poor Ex.: Example -
TABLE 2 Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Ex. Component Substance HLB 17 18 19 20 21 22 23 24 25 26 Cleaner (nonionic Diglycerol monocaprylate 8.7 surfactant) Tetraglycerol monolaurate 10.3 Decaglycerol monocaprylate 16.0 Solubilizing agent Polysorbate 80 15.7 Alkali metal salt or Sodium hydrogen carbonate — 0.2 0.5 1 1 1 1 1 alkaline earth metal salt Trisodium citrate dihydrate — 0.2 0.5 1 0.2 0.5 1 2 Defoaming agent Silicone resin emulsion — Solvent Purified water — (q.s.) (q.s.) (q.s.) (q.s.) (q.s.) (q.s.) (q.s.) (q.s.) (q.s.) (q.s.) Combined HLB of surfactants — — — — — — — — — — Cleaning rate (%) 143 169 201 121 121 126 243 168 409 167 Stability (one month) 5° C. Good Good Good Good Good Good Good Good Good Good 40° C. Good Good Good Good Good Good Good Good Good Good Ex.: Example -
TABLE 3 Com. Com. Com. Com. Com. Com. Component Substance HLB Ex. 1 Ex. 2 Ex. 3 Ex. 4 Ex. 5 Ex. 6 Cleaner (nonionic Diglycerol monocaprylate 8.7 3 3 surfactant) Tetraglycerol monolaurate 10.3 Decaglycerol monocaprylate 16.0 5 15 Solubilizing agent Polysorbate 80 15.7 6 9 9 Alkali metal salt or Sodium hydrogen carbonate — alkaline earth metal salt Trisodium citrate dihydrate — Defoaming agent Silicone resin emulsion — Solvent Purified water — 100 (q.s.) (q.s.) (q.s.) (q.s.) (q.s.) Combined HLB of surfactants — 16.0 16.0 13.4 14.0 15.7 Cleaning rate (%) 100 106 112 99 97 98 Stability (one month) 5° C. — Good Good Poor Good Good 40° C. — Good Good Poor Poor Good Com. Ex.: Comparative Example - To purified water were added sodium hydrogen carbonate and/or trisodium citrate dihydrate according to the formulas in Table 4, and the mixture was thoroughly stirred to give a cleaner.
- To water were added diglycerol monocaprylate and decaglycerol monocaprylate according to the formulas in Table 4. The mixture was heated to 80° C. in a water bath while stirred with a stirrer. After the dissolution, the solution was allowed to cool down to room temperature. Purified water was added to a total amount of 100 g to give a cleaner.
- Purified water in an amount of 100 g was used as a cleaner.
-
TABLE 4 Com. Ex. Ex. Ex. Ex. Component Substance HLB Ex. 7 27 28 29 30 Cleaner (nonionic Diglycerol monocaprylate 8.7 3 3 surfactant) Decaglycerol monocaprylate 16.0 9 12 Alkali metal salt or Sodium hydrogen carbonate — 1 3 alkaline earth metal salt Trisodium citrate dihydrate — 1 Solvent Purified water — 100 (q.s.) (q.s.) (q.s.) (q.s.) Combined HLB of surfactants — — — 14.2 14.5 Com. Ex.: Comparative Example Ex.: Example - Test Example 3
- 1) Fatty tissue from a resected porcine stomach model is melted by heating to recover oil.
2) A certain amount of the oil of the above 1) is applied to the surface of an endoscope lens in a dry state, and an image through the lens is taken.
3) The distal end of the endoscope is immersed in 10 mL of the cleaner of Example 27, Example 28, Example 29, Example 30, or Comparative Example 7 in a beaker for 60 seconds.
4) After air supply and aspiration are performed, an image through the lens is taken.
5) The photographs of the above 2) and 4) are compared for the evaluation of the cleaning effect. - Excellent: 90% or more of debris was removed.
- Good: 70% or more and less than 90% of debris was removed.
- Fair: 50% or more and less than 70% of debris was removed.
- Poor: Less than 50% of debris was removed.
- The results of Test Example 3 are shown in
FIG. 3 . - Comparative Example 7 hardly removed the debris whereas all of the cleaners of Examples 27 to 30 showed high debris removal rates of 70% or more.
- To water were added diglycerol monocaprylate and decaglycerol monocaprylate according to the formulas in Table 5. The mixture was heated to 80° C. in a water bath while stirred with a stirrer. After the dissolution, the solution was allowed to cool down to room temperature. Purified water was added to a total amount of 100 g to give a cleaner.
- Purified water in an amount of 100 g was used as a cleaner.
-
TABLE 5 Com- parative Example Example Component Substance HLB Example 8 31 32 Cleaner Diglycerol 8.7 3 3 (nonionic monocaprylate surfactant) Decaglycerol 16.0 9 12 monocaprylate Solvent Purified water — 100 (q.s.) (q.s.) Combined HLB of surfactants — 14.2 14.5 - 1) Fatty tissue from a resected porcine stomach model is melted by heating, and 20 g of the obtained oil and 0.1 g of Oil Red are dissolved in 60 mL of chloroform.
2) In the oil film model solution of the above 1), an endoscope hood (attachment) is immersed for 1 second, and a photograph of the hood is taken.
3) The hood of the above 2) is immersed in 20 mL of the cleaner of Example 31, Example 32, or Comparative Example 8 at 25±1° C. in a beaker for 1 second, and a photograph of the hood is taken.
4) The photographs of the above 2) and 3) are compared for the evaluation of the cleaning effect. - Good: 70% or more of debris was removed.
- Fair: 50% or more and less than 70% of debris was removed.
- Poor: Less than 50% of debris was removed.
- The results of Test Example 4 are shown in
FIG. 4 . - Both of Examples 31 and 32 showed high debris removal rates.
- To purified water were added diglycerol monocaprylate and decaglycerol monocaprylate according to the formulas in Table 6. The mixture was heated to 80° C. in a water bath while stirred with a stirrer. After the dissolution, the solution was allowed to cool down to room temperature. Purified water was added to a total amount of 100 g to give a cleaner.
- Purified water in an amount of 100 g was used as a cleaner.
-
TABLE 6 Com- parative Example Example Component Substance HLB Example 9 33 34 Cleaner Diglycerol 8.7 3 3 (nonionic monocaprylate surfactant) Decaglycerol 16.0 9 12 monocaprylate Solvent Purified water — 100 (q.s.) (q.s.) Combined HLB of surfactants — 14.2 14.5 - 1) On a glass slide, a drop of 50 μL of the cleaner (25±1° C.) obtained, in Example 33, Example 33, or Comparative Example 9 is placed, and spread over the entire surface.
2) The glass slide of the above 1) is held horizontal at 5° C./ambient humidity for 10 minutes.
3) The glass slide is transferred into a thermostatic chamber at 40° C./75% RH and held horizontal for 2 minutes.
4) Immediately after taking the glass slide out of the thermostatic chamber, the antifogging effect is evaluated at room temperature/ambient humidity and expressed as Good, Fair, or Poor. - Good: Sufficient antifogging effect was observed.
- Fair: Slight antifogging effect was observed.
- Poor: No antifogging effect was observed.
- The results of Test Example 5 are shown in
FIG. 5 . - Examples 33 and 34 showed high antifogging effect.
- Using the cleaner of Example 15 as an antifoulant, antifouling treatment was given to an endoscope lens. The anti fouling treatment was performed by applying the antifoulant to the surface of the endoscope lens with a cotton swab.
- Using the treated endoscope, endoscopic submucosal dissection (ESD) in patients with colon tumors was carried out in a conventional manner. Endoscopic images obtained after the submucosal dissection were observed and evaluated based on the following criteria.
- Grade 0: no debris was observed on the endoscope lens, or debris was perfectly removed by washing the lens inside the colon and rectum with water injected from the forceps channel or water delivered by the endoscope system (
level 0 inFIG. 6 ). - Grade 1: debris was not perfectly removed by the above-described washing with water but did not result in severely blurred endoscopic view (
level 1 inFIG. 6 ). - Grade 2: debris was not perfectly removed by the above-described washing with water and ESD could not be continued due to severely blurred endoscopic view (
level 2 inFIG. 6 ). - Grade 0: no fat in the adipose tissue (
level 0 inFIG. 7 ). - Grade 1: a small amount of fat in the adipose tissue (
level 1 inFIG. 7 ). - Grade 2: a large amount of fat in the adipose tissue, which made the dissection difficult to carry out (
level 2 inFIG. 7 ). - The number of the patients was 92, the mean age was 68.3 (35 to 85 years, male/female (%)=51.0/49.0), the mean tumor size was 31.8 mm, and the mean procedure time was 71.1 minutes.
- During the ESD, cloudiness of the lens was not observed.
- ESD was performed using an endoscope that was subjected to antifouling in the same manner as in Example 30 except for using, instead of the cleaner of Example 15, a commercially available endoscopic antifogging agent for use in natural orifice (“SL cleaner” made by Sugiura Laboratory, Inc.; components: linear alkylbenzene sulfonate (anionic surfactant), polyoxyethylene alkyl ether, and ethanol). Endoscopic images obtained during and after the submucosal dissection were observed and evaluated.
- The number of the patients was 103, the mean age was 68.8 (41 to 92 years, male/female (%)=63.1/36.9), the mean tumor size was 32.7 mm, and the mean procedure time was 77.1 minutes. No significant difference was observed compared with the cases in Example 35 (p=NS).
- The results obtained in Examples 35 and 36 are summarized in the following table. The “%” for each grade means the percentage out of ail patients.
-
TABLE 7 Amount of fat in submucosal adipose tissue Accumulation of debris after submucosal dissection Grade Grade Grade Grade Grade Grade Grade Grade 0 1 2 1 + 2 0 1 2 1 + 2 (%) (%) (%) (%) p value (%) (%) (%) (%) p value Ex. 35 47.8 39.1 13.0 52.1 NS 85.9 12.0 2.1 14.1 <0.01 Ex. 36 51.5 39.8 8.7 48.5 67.0 24.3 8.7 33.0 Ex.: Example - As clearly shown in the table, the antifouling treatment successfully reduced the accumulation of debris on the endoscope lens after the ESD of the patients. In particular, the amount of fat in the submucosal adipose tissue in the patients was similar (not significant (NS)) between Example 35 and Example 36, but Example 35 using the antifoulant containing the specific surfactants as antifouling components significantly reduced the accumulation of debris on the endoscope lens compared with Example 36 using the commercially available endoscopic antifoulant for use in natural orifice.
- From the patients in Example 36, five cases determined as
Grade 1 and five cases determined asGrade 2 in terms of the accumulation of debris after submucosal dissection were selected, and the cleaning effect of the cleaner of Example 15 on an endoscope lens (and an endoscope hood (attachment)) was further evaluated inside the bodies of these patients. - The cleaning was performed as follows. The distal end of the endoscope was deflected upward with its face up, and the cleaner of Example 15 was injected from the forceps channel so that the cleaner was kept in the endoscope hood (attachment) for 30 seconds (i.e., the endoscope lens was kept immersed in the cleaner for 30 seconds).
- The images through the lens after the cleaning were observed and evaluated based on the same criteria as in Example 35. All of the five cases with
Glade 1 showed the results withGrade 0. Of the five cases withGrade 2, three cases showed the results withGrade 1 and the other two cases showed the results withGrade 0. - The results revealed that even for cases) with
Grade - The present invention provides a cleaner for an endoscope, the cleaner being used inside a living body during an endoscopic surgical procedure. The cleaner of the present invention can be used to clean debris from an endoscope lens and/or an endoscope hood (attachment) inside a living body, which feature greatly reduces the burden on a physician and the patient during an endoscopic surgical procedure. The cleaner of the present invention improves the antifogging properties of an endoscope lens and/or an endoscope hood (attachment), and thereby increases the usability of an endoscopic surgical procedure.
- The present invention also provides an antifoulant to be used for an endoscope lens and/or an endoscope hood (attachment) before an endoscopic surgical procedure. The antifoulant reduces or prevents the accumulation of debris on the endoscope lens and/or the endoscope hood (attachment).
- 1 Objective lens
- 2 light guides
- 3 Forceps channel
- 4 Water-jet nozzle
- 5 Air/water, nozzle
- 6 Endoscope hood (attachment)
Claims (13)
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EP (1) | EP3053996A4 (en) |
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CN105849244A (en) | 2016-08-10 |
JP6504404B2 (en) | 2019-04-24 |
EP3053996A4 (en) | 2017-05-31 |
JPWO2015046532A1 (en) | 2017-03-09 |
WO2015046532A1 (en) | 2015-04-02 |
US10264957B2 (en) | 2019-04-23 |
EP3053996A1 (en) | 2016-08-10 |
CN105849244B (en) | 2019-05-17 |
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