US20160039964A1

US20160039964A1 - Well defined, highly crosslinked nanoparticles and method for making same

Info

Publication number: US20160039964A1
Application number: US14/822,039
Authority: US
Inventors: Hideki Kitano; Yaohong Chen
Original assignee: Bridgestone Corp
Current assignee: Bridgestone Corp
Priority date: 2009-12-29
Filing date: 2015-08-10
Publication date: 2016-02-11
Also published as: US20110236686A1; US9115222B2

Abstract

A method is provided for making nanoparticles, including the steps of: combining a hydrocarbon solvent and an aprotic, polar co-solvent, a mono-vinyl aromatic monomer, polymerization initiator, a solution stabilizer, and a first charge of a cross-linking agent. Subsequently, a second charge of cross-linking agent is added. The nanoparticles have an average diameter of 5 nanometers to about 10,000 nanometers. Spherical nanoparticles are also provided that include a cross-linking agent comprising 30% to 60% by weight of the combined weight of a mono-vinyl aromatic species and the cross-linking agent. The spherical nanoparticles also meet the following equation:

0.90≦(D1/D2)≦1.1

- wherein D1 is a first diameter of a nanoparticle and D2 is a second diameter of the nanoparticle, and D1 and D2 intersect at right angles.

Description

CROSS-REFERENCE TO RELATED APPLICATION

This application is a divisional of U.S. application Ser. No. 12/979,719, filed Dec. 28, 2010, which, in turn, claims the benefit of U.S. Provisional Application No. 61/290,755, filed on Dec. 29, 2009. These prior applications, including the entire written description and drawing figures, are hereby incorporated into the present application by reference.

FIELD

The technology disclosed herein is generally related to nanoparticles. This disclosure also provides a method of making such nanoparticles.

BACKGROUND AND SUMMARY

Polymer nanoparticles have attracted increased attention over the past several years in a variety of fields including catalysis, combinatorial chemistry, protein supports, magnets, and photonic crystals. Nanoparticles have been used in rubber compositions to improve physical properties of rubber moldability and tenacity. In some instances the inclusion of polymer compositions with certain functional groups or heteroatomic monomers can produce beneficial and unexpected improvements in rubber compositions.
Charged nanoparticles may have a number of possible applications, such as in electronic devices, or in rubber or other polymer matrices. In some electronic display applications, such as QR-LPD, charged particles may be used to present a pictorial or textual display. It is a challenge, however, to provide particles that have a durable constitution and a stable charge. It is also a challenge to produce durable nanoparticles that are very hard and have highly spherical surfaces.
Herein, a method is provided for making nanoparticles, including the steps of: combining a hydrocarbon solvent and an aprotic, polar co-solvent, a mono-vinyl aromatic monomer, polymerization initiator, a solution stabilizer, and a first charge of a cross-linking agent. Subsequently, a second charge of cross-linking agent is added. The nanoparticles have an average diameter of 5 nanometers to about 10,000 nanometers.
Furthermore, spherical cross-linked nanoparticles are also provided. The spherical nanoparticles have a core formed from a polymeric seed that includes a mono-vinyl aromatic core species cross-linked with a cross-linking agent. The core has an average diameter of 5 nanometers to 10,000 nanometers. The mono-vinyl aromatic core species comprises polymeric chains radiating from a center of the core. Furthermore, the nanoparticles meet the following equation:
0.90≦(D1/D2)≦1.1
wherein D1 is a first diameter of a nanoparticle and D2 is a second diameter of the nanoparticle, and D1 and D2 intersect at right angles.
Furthermore, spherical cross-linked nanoparticles are also provided. The spherical nanoparticles have a core formed from a polymeric seed that includes a mono-vinyl aromatic core species cross-linked with a cross-linking agent. The core has an average diameter of 5 nanometers to 10,000 nanometers, and the cross-linking agent comprises 30% to 60% by weight of the combined weight of the mono-vinyl aromatic species and the cross-linking agent. The mono-vinyl aromatic core species comprises polymeric chains radiating from a center of the core. Furthermore, the nanoparticles meet the following equation:
0.90≦(D1/D2)≦1.1
wherein D1 is a first diameter of a nanoparticle and D2 is a second diameter of the nanoparticle, and D1 and D2 intersect at right angles.
Herein throughout, unless specifically stated otherwise: “vinyl-substituted aromatic hydrocarbon” and “alkenylbenzene” are used interchangeably. Furthermore, the terms “a” and “the,” as used herein, mean “one or more.”

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a graph showing yield % vs. beginning amount of cross-linking agent.

FIG. 2 is an SEM image of a collection of nanoparticles according to Example 1.

FIG. 3 is an SEM image of a collection of nanoparticles according to Example 2.

FIG. 4 is an SEM image of a collection of nanoparticles according to Example 3.

FIG. 5 is an SEM image of a collection of nanoparticles according to Example 4.

FIG. 6 is an SEM image of a collection of nanoparticles according to Example 5.

FIG. 7 is an SEM image of a collection of nanoparticles according to Example 6.

DETAILED DESCRIPTION

A method for making highly spherical, highly crosslinked nanoparticles is described herein. The method utilizes a core-first dispersion polymerization synthesis method in conjunction with a dual solvent system and a step-wise or metered addition of cross-linking agent. Synergistically, the dual solvent system and the step-wise or metered addition of cross-linking agent promote higher yields and better crosslinking and discrete, spherical particle shapes. The yield can reach up to complete conversion of the monomer and cross-linking agent.
Such nanoparticles may have various uses, including use as child particles in electronic displays such as electronic paper displays that use QR-LPD technology. Further details on QR-LPD and such particles are disclosed in U.S. Published Applications 2008/0174854 and 2006/0087718, and U.S. Pat. No. 7,236,291, which are incorporated herein by reference. A durable particle imparted with a stable charge is generally desirable, but it is especially desirable in QR-LPD displays where particles are subjected to significant frictional forces that tend to damage the structural and charge characteristics of the particles.
According to an embodiment of the method, the nanoparticle is formed by a core-first living dispersion polymerization method. Living anionic dispersion polymerization or living free radical dispersion polymerization may be used. Living anionic dispersion polymerization may be favorable over free radical dispersion polymerization for some applications. The living dispersion polymerization methods described herein are superior to emulsion synthesis methods for many applications. Furthermore, the nanoparticles synthesized by the methods described herein differ from star polymers in that they have a larger and decentralized core.
In dispersion polymerization, the reaction is effected by polymerizing a monomer in an organic liquid in which the resulting polymer is insoluble, using a steric stabilizer to stabilize the resulting particles of insoluble polymer in the organic liquid. Dispersion polymerization is used to prevent the propagating polymeric core from precipitating out of solution. This technique allows for a sizeable core to be formed in a range of about 5 nanometers up to about 10,000 nanometers while remaining in solution. Consequently, a wide range of solvents may be used in which the polymeric core would be otherwise insoluble.
Building on the flexibility for solvents provided by the core-first dispersion method, a dual solvent system is used in the method described herein. The dual solvent system includes a hydrocarbon solvent and an aprotic, polar co-solvent. The core monomer is soluble in the hydrocarbon solvent, but the polymerized monomer is relatively insoluble in the hydrocarbon solvent. The solvent also promotes aggregation of the poly(alkenylbenzene) and stabilization of the dispersion polymerization.
The co-solvent is an aprotic, polar solvent that promotes swelling of the formed particle and propagation of the polymer chains that comprise the nanoparticle. The polymer chains and modifiers are relatively soluble in the co-solvent while the monomer is relatively insoluble in the co-solvent. The co-solvent may also be a structural modifier. The monomers and polymer chains should both be soluble in the co-solvent.
Specific examples of solvents include aliphatic hydrocarbons, such as pentane, hexane, heptane, octane, nonane, and decane, as well as alicyclic hydrocarbons, such as cyclohexane, methyl cyclopentane, cyclooctane, cyclopentane, cycloheptane, cyclononane, and cyclodecane. These hydrocarbons may be used individually or in combination to comprise the hydrocarbon solvent of the dual solvent system. Selection of a solvent in which one monomer forming the nanoparticles is more soluble than another monomer forming the shell of the nanoparticles is preferred for some applications.
Specific examples of co-solvents include THF, dioxane, 2-methyl THF, diethyl ether, dimethyl sulfoxide, dimethylformamide, and hexamethylphosphorotriamide. These solvents may be used individually or in combination to comprise the polar, aprotic co-solvent of the dual solvent system.
The solvent and co-solvent may be added together or separately to the reactor. The volume ratio of hydrocarbon solvent to polar, aprotic solvent ranges from about 99.9:0.1 to about 70:30, such as about 85:15 to about 95:5, about 90:10 to about 99:1, or about 94:6 to about 98:2.
In a generalized embodiment of the core-formation step of the method, a reactor is provided with the dual solvent system, into which a mono-vinyl monomer species and a steric stabilizer are added. A polymerization initiator is also added to the reactor. A randomizing agent may also be added to the reactor.
A step-wise or metered addition of cross-linking agent is also begun at this point. In one embodiment, a first charge of cross-linking agent is added that is about 1 to about 50% of the total cross-linking agent to be charged, such as about 1 to about 20%, about 5.25 to about 11.5%, or about 3.5% to about 11.5%. The first charge may be added all at once or may be metered over time as the polymerization progresses.
Without being bound by theory, the incremental addition of cross-linking agent allows adjustment of the reactivity ratio of the monomer and cross-linking for randomizing the copolymerization.
The first charge of cross-linking agent and the initiator may be added in one charge to the reactor.
As the reaction proceeds, the mono-vinyl monomer is polymerized and cross-linked with the cross-linking agent. The mono-vinyl polymer chains are tied together by the first charge of cross-linking agent, wherein the mono-vinyl polymer chains have living ends at the surface of the core. The living ends are at the surface of the core due to their higher affinity to the solvent than the mono-vinyl species. The surface of the core is stabilized by the steric stabilizer, such as polystyrene-polybutadiene diblock copolymer. The stabilizer is adsorbed on the surface of the core.
After a substantial amount of monomer has been polymerized, i.e. a substantial monomer conversion, a second charge of cross-linking agent is added. For example, the second charge of cross-linking agent can be added after a monomer conversion of about 51 to about 100%, such as about 75 to about 100%, about 75 to about 95%, or about 90 to about 100%. The second charge of cross-linking agent is added, and may be added in a step-wise or metered manner. In one embodiment, the amount of the second charge of cross-linking agent is the difference between the total amount of cross-linking agent and the amount of cross-linking agent used in the first charge. In one embodiment, the second charge of cross-linking agent is added that is about 99 to about 50% of the total cross-linking agent to be charged, such as about 80 to about 99%, about 88.5 to about 94.75%, or about 88.5% to about 96.5%. The second charge may be added all at once or may be metered over time. In another embodiment, more than two charges may be used.
By this method a total yield of nanoparticles may approach about 100%, such as about 80 to about 98%, or about 85% to about 95%.
With respect to the monomers and solvents identified herein, nanoparticles are formed by maintaining a temperature that is favorable to polymerization of the selected monomers in the selected solvent(s). Reaction temperatures are, for example, in the range of about −40 to about 250° C., such as a temperature in the range of about 0 to about 150° C. The interaction of monomer selection, temperature and solvent, facilitates the formation of polymer chains which comprise the nanoparticle.
The ratio of mono-vinyl monomer species to total cross-linking agent may range from about 30:70 to about 90:10, such as about 57:43 to about 72:28, about 51:49 to about 65:35, or about 65:35 to about 85:15. The cross-linking agent can also work as a co-monomer at the outset of the polymerization.
The incremental addition of cross-linking agent can adjust the reactivity ratio of the monomer and cross-linking agent for randomizing the copolymerization. A more uniform structure of the particles is formed in the dual solvent system and it allows the partly formed nanoparticles to swell and incorporate the cross-linking agent more densely into the core structure.
The highly cross-linked core enhances the uniformity, durability, and permanence of shape and size of the resultant nanoparticle. The example method may be performed in a single batch, and there is no requirement to isolate and dry the core before grafting the shell.
Specific examples of mono-vinyl monomer species include mono-vinyl aromatic species, such as styrene, α-methylstyrene, 1-vinyl naphthalene, 2-vinyl naphthalene, 1-α-methyl vinyl naphthalene, 2-α-methyl vinyl naphthalene, vinyl toluene, methoxystyrene, t-butoxystyrene, as well as alkyl, cycloalkyl, aryl, alkaryl, and aralkyl derivatives thereof, in which the total number of carbon atoms in the combined hydrocarbon is not greater than 18, as well as any di- or tri-vinyl substituted aromatic hydrocarbons, and mixtures thereof. Further examples of mono-vinyl monomer species include non-aromatic mono-vinyl monomer species, such as vinyl acetate, vinyl-methacrylate, and vinyl-alcohols.
Crosslinking agents that are at least bifunctional, wherein the two functional groups are capable of reacting with the mono-vinyl species of the core are acceptable. Examples of suitable cross-linking agents include multiple-vinyl aromatic monomers in general. Specific examples of cross-linking agents include di- or tri-vinyl-substituted aromatic hydrocarbons, such as diisopropenylbenzene, divinylbenzene, divinyl ether, divinyl sulphone, diallyl phthalate, triallyl cyanurate, triallyl isocyanurate, 1,2-polybutadiene, N,N′-m-phenylenedimaleimide, N,N′-(4-methyl-m-phenylene)dimaleimide, triallyl trimellitate acrylates, methacrylates of polyhydric C₂-C₁₀alcohols, acrylates and methacrylates of polyethylene glycol having from 2 to 20 oxyethylene units, polyesters composed of aliphatic di- and/or polyols, or maleic acid, fumaric acid, and itaconic acid. Multiple-vinyl aromatics, such as divinylbenzene provides excellent properties and are compatible with common solvents.
Specific examples of suitable steric stabilizers include styrene-butadiene diblock copolymer, polystyrene-b-polyisoprene, and polystyrene-b-polydimethylsiloxane.
A 1,2-microstructure controlling agent or randomizing modifier is optionally used to control the 1,2-microstructure in the mono-vinyl monomer units of the core. Suitable modifiers include 2,2-bis(2′-tetrahydrofuryl)propane, hexamethylphosphoric acid triamide, N,N,N′,N′-tetramethylethylene diamine, ethylene glycol dimethyl ether, diethylene glycol dimethyl ether, triethylene glycol dimethyl ether, tetraethylene glycol dimethyl ether, tetrahydrofuran, 1,4-diazabicyclo[2.2.2]octane, diethyl ether, triethylamine, tri-n-butylamine, tri-n-butylphosphine, p-dioxane, 1,2-dimethoxy ethane, dimethyl ether, methyl ethyl ether, ethyl propyl ether, di-n-propyl ether, di-n-octyl ether, anisole, dibenzyl ether, diphenyl ether, dimethylethylamine, bis-oxalanyl propane, tri-n-propyl amine, trimethyl amine, triethyl amine, N,N-dimethyl aniline, N-ethylpiperidine, N-methyl-N-ethyl aniline, N-methylmorpholine, tetramethylenediamine, oligomeric oxolanyl propanes (OOPs), 2,2-bis-(4-methyl dioxane), and bistetrahydrofuryl propane. A mixture of one or more randomizing modifiers also can be used. The ratio of the modifier to the monomers can vary from a minimum as low as 0 to a maximum as great as 4000 millimoles, for example 0.01 to 3000 millimoles, of modifier per hundred grams of monomer currently being charged into the reactor. As the modifier charge increases, the percentage of 1,2-microstructure (vinyl content) increases in the conjugated diene contributed monomer units in the surface layer of the polymer nanoparticle. The 1,2-microstructure content of the conjugated diene units is for example, within a range of about 5% and about 95%, such as less than about 35%.
Suitable initiators for the core formation process include anionic initiators that are known in the art as useful in the polymerization of mono and multiple-vinyl monomers. Exemplary organo-lithium initiators include lithium compounds having the formula R(Li)_x, wherein R represents a C₁-C₂₀hydrocarbyl radical, such as a C₂-C₈hydrocarbyl radical, and x is an integer from 1 to 4. Typical R groups include aliphatic radicals and cycloaliphatic radicals. Specific examples of R groups include primary, secondary, and tertiary groups, such as n-propyl, isopropyl, n-butyl, isobutyl, and t-butyl.
Specific examples of initiators include ethyllithium, propyllithium, n-butyllithium, sec-butyllithium, and tert-butyllithium; aryllithiums, such as phenyllithium and tolyllithium; alkenyllithiums such as vinyllithium, propenyllithium; alkylene lithium such as tetramethylene lithium, and pentamethylene lithium. Among these, n-butyllithium, sec-butyllithium, tert-butyllithium, tetramethylene lithium, and mixtures thereof are specific examples. Other suitable lithium initiators include one or more of: p-tolyllithium, 4-phenylbutyl lithium, 4-butylcyclohexyl lithium, 4-cyclohexylbutyl lithium, lithium dialkyl amines, lithium dialkyl phosphines, lithium alkyl aryl phosphine, and lithium diaryl phosphines.
Free radical initiators may also be used in conjunction with a free radical polymerization process. Examples of free-radical initiators include: 2,2′-azo-bis(isobutyronitril, 1,1′-azobis(cyclohexanecarbonitrile), 2,2′-azobis(2-methylpropionamidine)dihydrochloride, 2,2′-azobis(2-methylpropionitrile), 4,4′-azobis(4-cyanovaleric acid), 1,1-bis(tert-amylperoxy)cyclohexane, 1,1-bis(tert-butylperoxy)-3,3,5-trimethylcyclohexane, 1,1-bis(tert-butylperoxy)cyclohexane, 2,2-bis(tert-butylperoxy)butane, 2,4-pentanedione peroxide, 2,5-bis(tert-butylperoxy)-2,5-dimethylhexane, 2,5-bis(tert-butylperoxy)-2,5-dimethylhexane, 2-butanone peroxide, 2-butanone peroxide, 2-butanone peroxide, benzoyl peroxide, cumene hydroperoxide, di-tert-amyl peroxide, dicumyl peroxide, lauroyl peroxide, tert-butyl hydroperoxide, ammonium persulfate, hydroxymethanesulfinic acid monosodium salt dehydrate, potassium persulfate, and reagent grade sodium persulfate.
Functionalized lithium initiators are also contemplated as useful in the polymerization of the core species. A functionalized initiator serves to functionalize the core, and the functional groups are likely distributed throughout the surface and interior of the core. Example functional groups include amines, formyl, carboxylic acids, alcohols, tin, silica, and mixtures thereof.
Amine-functionalized initiators include those that are the reaction product of an amine, an organo lithium, and a solubilizing component. The initiator may have the general formula:
(A)Li(SOL)_y
where y is from 1 to 3; SOL is a solubilizing component selected from the group consisting of hydrocarbons, ethers, amines or mixtures thereof; and, A is selected from the group consisting of alkyl, dialkyl and cycloalkyl amine radicals having the general formula:
and cyclic amines having the general formula:
where R¹is selected from the group consisting of alkyls, cycloalkyls or aralkyls having from 1 to 12 carbon atoms, and R²is selected from the group consisting of an alkylene, substituted alkylene, oxy- or N-alkylamino-alkylene group having from 3 to 16 methylene groups. A specific example of a functionalized lithium initiator is hexamethylene imine propyllithium.
Tin functionalized lithium initiators may also be useful in synthesizing the nanoparticles. Suitable tin functionalized lithium initiators include tributyl tin lithium, trioctyl tin lithium, and mixtures thereof.
Anionic initiators generally are useful in amounts ranging from about 0.01 to about 60 millimoles per hundred grams of monomer charge. Free radical initiators are useful in amounts ranging from about 6 to about 100 millimoles per hundred grams of monomer charge.
The core may range in size from 5 nanometers to about 10,000 nanometers, for example about 25 to about 1,000 nanometers, about 40 to about 150 nanometers, about 50 to about 125 nanometers, or about 100 to about 1,000 nanometers. In an embodiment, the core differs from that of a star polymer in that it does not emanate from a single point, but instead is decentralized and has a minimum size of 5 nanometers.
The core may be useful in some applications without further addition of a shell. In one embodiment, the living polymer chain ends are terminated and the crosslinked core is the nanoparticle. In another embodiment, a shell layer or layers are added to the core.
In an embodiment, a shell for the nanoparticles is formed by grafting or polymerizing a shell species onto the living ends of the cross-linked core. The nanoparticle is thus formed with polymers or copolymers extending from the cross-linked core into the uncrosslinked shell. The shell species can be selected from a variety of oligomers, polymers, monomers, or macromolecules and functionalized versions of all of these. Because the shell is formed last, the shell species does not need to be as stable as it would if it were formed first and had to survive the core formation and cross-linking process. Thus, the core-first process can produce many new nanoparticles that were difficult or impossible to make with a shell first process. In addition, the core-first dispersion process provides an easier and more reliable method to make functionalized nanoparticles in general.
In one embodiment, the shell species is a polymer that has already been polymerized in a separate reactor and then added to the reactor that holds the core with living ends. An addition of the preformed polymer to the reactor containing the core would result in the polymer chains being grafted to the cross-linked core, thereby forming a shell with polymer brushes. The term “polymer brushes” or “brush-like surface” as used herein, is used to mean the uncrosslinked polymers that extend into the shell of the nanoparticles. Like the term “hairy,” the term “brushes” denotes the uncrosslinked nature of the shell. Alternatively, the preformed polymer may be functionalized with a functional initiator, a functional terminator, or both in the separate reactor and then grafted onto the living ends of the core, thereby forming functionalized polymer brushes in the shell of the nanoparticle.
In another embodiment, the shell species is added as a monomer to the reactor containing the core and polymerized with initiator in the same reactor with the core. The shell would thus comprise polymer brushes of the shell species. Optionally, functional terminators could be used to functionalize the polymer brushes of the shell.
In another embodiment, the shell species is a monomer containing a heteroatom. The heteroatomic monomer is polymerized and grafted to the core as described above.
The shorter the uncrosslinked polymer brushes are, the harder and more well-defined the nanoparticle will be. This is due to the proximity of the ends of the polymer brushes to the hard core and the thermodynamic effects of the same.
In another embodiment, the shell species is a single monomer unit. The unit may be a hydrocarbon or contain one or more heteroatoms, and it may be functionalized. The monomer is added with no initiator and bonds to the living ends of the core. This embodiment forms a nanoparticle with a single monomer unit shell.
In another embodiment, the shell species is a macromolecule having a molecular weight up to about 10,000 g/mol or an oligomer. The shell species is added to the reactor containing the core. The macromolecule or oligomer is thus grafted onto the living ends of the core. Various functional groups may be present in the macromolecule or oligomer.
In another embodiment, the shell species is itself a functional terminator. When added to the reactor containing the core, the functional terminator bonds to the living ends of the core and terminates the core with a functional group. In this example, the functional group is considered the shell.
Example shell species generally include hydrocarbons, heteroatomic species, polar functionalized species, water-soluble species, and thermoplastic and plastic elastomers.
Hydrocarbon shell species include C₄to C₈conjugated dienes, such as, 1,3-butadiene, isoprene, and 1,3-pentadiene. Olefinic species such as ethylene, propylene, isobutylene, and cyclohexene may also be used.
Heteroatomic shell species include species containing O, N, S, P, Cl, Ti, and Si atoms, such as, epoxides, urethanes, esters, ethers, imides, amines, carbonates, siloxanes, halogens, metals, synthetic oils, and vegetable oils. Specific examples include, polydimethylsiloxane (PDMS), polyethylene oxide (PEO), halogenated butyl rubber, polyethylene teraphthalate (PET), polyethylene glycol (PEG), polyphenylene oxide (PPO), polypropylene glycol) diglycidyl ether (PPO-EO2), polyvinyl alcohol, pyridine, carbazole, imidazole, diethylamino-styrene, and pyrrolidone. Example macromolecules or oligomers include polyethylene glycol, polyphenylene oxide, and polydimethylsiloxane.
Functional terminators for use with or as the shell species include SnCl₄, R₃SnCl, R₂SnCl₂, RSnCl₃, carbodiimides, N-methylpyrrolidine, cyclic amides, cyclic ureas, isocyanates, Schiff bases, 4,4′-bis(diethylamino) benzophenone, N,N′-dimethylethyleneurea, and mixtures thereof, wherein R is selected from the group consisting of alkyls having from 1 to 20 carbon atoms, cycloalkyls having from 3 to 20 carbon atoms, aryls having from 6 to 20 carbon atoms, aralkyls having from 7 to 20 carbon atoms, and mixtures thereof.
Additionally, the shell species may include copolymers, including random and block copolymers. These copolymers may include the hydrocarbon and heteroatomic monomers listed above. The copolymer shell species may be synthesized prior to introducing the species into the reactor with the core, or it may be polymerized after introduction into the reactor as described above.
Such multi-block polymers, are believed to aggregate to form micelle-like structures around the core, with the block that is the least soluble in the solvent directed toward the center of the core and the other block as a tail or brush extending therefrom. For example, in a hydrocarbon solvent, vinyl-substituted aromatic blocks are directed toward the center of the core and other blocks extend as tails therefrom. It is noted that a further hydrocarbon solvent charge or a decrease in polymerization mixture temperature may also be used, and may in fact be required, to obtain formation of the micelles. Moreover, these steps may be used to take advantage of the general insolubility of a vinyl-aromatic block. An exemplary temperature range for micelle formation is between −80 and 100° C., such as between 20° C. and 80° C.
Although the above description discusses the formation of multi-block polymers prior to micelle formation, it is noted that after the nanoparticles have formed, additional monomer charge(s), such as conjugated diene monomer and/or vinyl-substituted aromatic hydrocarbon monomer, can be added to the polymerization mixture as desired. In this manner, multi-block polymers may be formed when only diblock polymers form the nanoparticles. Moreover, it is feasible to form the micelles of the block co-polymers with a further monomer(s) charge thereafter. The sequential addition of various monomers allows growth of particle size and formation of the shell with different internal structures.
In an alternative embodiment the shell of the nanoparticles may be formed by grafting a charge agent containing species onto the living ends of the cross-linked core or terminating the living ends with a charge agent containing terminating agent. The nanoparticle is thus formed with polymers, copolymers, or the terminating agent of the core polymers extending from the cross-linked core into the shell. The nature and quantity of the charge agent allows control of the charge on the nanoparticle.
One method of adding a charge agent to the living ends of the nanoparticle core is through the addition of a functionalized terminator. The functionalized terminator includes a charge agent that has a fixed formal charge group that exists after the addition to the nanoparticle. By fixed formal charge it is meant a charge that results from an actual excess or deficiency of electrons, not merely a localized charge due to an electron rich area of the molecule.
Once the core is formed and a desired yield is obtained, the functional terminator containing the charge agent is added to the reactor. In an embodiment, this is a one-pot process that does not require a separate isolation step or drying step to isolate and dry the core.
The added terminator terminates the living ends of the mono-vinyl polymer chains of the core and places a functional group containing the charge agent on the end of the chains. In this embodiment the functional group is considered to be the shell layer of the nanoparticle. The very thin functional group shell layer has the advantage of being physically durable and resistant to frictional shearing forces. This is due to its short length and proximity to the highly crosslinked core of the nanoparticle.
By selecting a charge agent that has a known charge, one can craft a nanoparticle with a desired charge that is physically durable and resistant to frictional shearing forces. The charge agent may be selected from a variety of charge agents that have a fixed formal charge. For most applications species with a more stable, fixed, formal charge are preferred. Examples of compounds that may have a stable, fixed, formal charge include nitrogen- and oxygen-containing species, such as cyclic compounds, including without limitation, succinic anhydride, imidazole, pyridines, N,N-dimethylaminostyrene and N,N-diethylaminostyrene, including without limitation, pyridine silane or vinyl pyridine and the derivates of all the above. Nitrogen containing species that contain quaternary ammonium compounds have a particularly stable charge. Quaternary phosphonium and quaternary sulfonium compounds are similar species with stable charges. Nitrogen containing species, such as pyridines may readily be imparted with a positive formal charge, whereas oxygen containing species, such as succinic anhydride, may readily be imparted with a negative formal charge.
A second, more versatile, method of adding a charge agent to the living ends includes polymerizing one or more monomer units having a charge agent with a fixed formal charge onto the living ends of the nanoparticle core. Once the core is formed from the core formation process discussed above and a desired yield is obtained, a monomer that includes the charge agent may be added to the reactor along with a polymerization initiator. Again, this is a one-pot process that does not require separate isolation or drying of the core. The monomer containing the charge agent bonds to the living ends of the mono-vinyl polymer chains of the core. Depending on reaction conditions, and the amount of monomer and initiator, additional monomer-contributed units will propagate in polymer chains originating from the living ends of the mono-vinyl polymer chains of the nanoparticle core. In this way, the nanoparticle comprises diblock polymer chains with a mono-vinyl block that is crosslinked and a charge agent block. The charge agent block may be considered to be the shell layer of the nanoparticle, while the cross-linked mono-vinyl block may be considered to be the core layer of the nanoparticle. Similarly, the shell block of the diblock polymers that comprise the nanoparticle include the charge agent monomers as monomer contributed units, while the core block includes the mono-vinyl monomers as monomer contributed units.
In another method adding a charge agent to the living ends of the nanoparticle core, the charge agent is a monomeric species that has already been polymerized in a separate reactor and then added to the reactor that holds the core with living ends. An addition of the preformed polymeric charge agent to the reactor containing the core would result in the polymer chains being grafted to the cross-linked core, thereby forming a shell with propagated charge agent chains.
In another method adding a charge agent to the living ends of the nanoparticle core, a charge agent monomer is added to the reactor. The monomer may be a hydrocarbon containing one or more heteroatoms, and it may be functionalized. The monomer is added with no initiator and grafts onto the living ends of the core. This method forms a nanoparticle with a shell having a single charge agent layer.
The charge of the nanoparticle can be controlled by the selection of the charge agent, and it can also be controlled by the number of charge agents present in the nanoparticle. The number of charge agents in the nanoparticle is a function of the amount of charge-agent-containing monomer and the length of the charge agent block of the polymer chains. It is also a function of the number of living ends present on the surface of the core (onto which the charge agent-containing-monomer attaches).
The nanoparticle core will have a negative charge due to the electron-rich localized charge induced by the mono-vinyl monomer contributed units and the cross-linking agent. Addition and polymerization of a shell monomer with a positive charge agent such as pyridine will cause the overall charge of the nanoparticle to be less negative, and continued addition and polymerization of the monomer will cause the charge on the nanoparticle to become positive. Conversely, addition and polymerization of a shell monomer with a negative charge agent such as succinic anhydride will cause the overall charge of the nanoparticle to be more negative. Thus, in general, the more charge agent monomer-contributed units that are present in the shell layer of the nanoparticle, and the longer each charge agent block polymer chain is, the more positive or negative the charge on the nanoparticle will become according to whether a positive or negative charge agent is used. In this manner one can select a charge agent and polymerize additional monomer units until a desired charge is reached.
A wide range of equilibrium weight-average charge values can be reached by this method. For example, the charge may range from about −500 μC/g to about 600 μC/g, such as about −300 μC/g to about 300 μC/g, or about −150 μC/g to about 150 μC/g. Negatively charged nanoparticles may, for example, have charges of about −10 μC/g or less, such as about −50 μC/g or less, about −500 μC/g to about −50 μC/g, or about −150 μC/g to about −50 μC/g. Positively charged nanoparticles may have charges of greater than about 0 μC/g, such as about 50 μC/g or greater, about 1 to about 600 μC/g, about 100 to about 300 μC/g, or about 300 to about 600 μC/g. The amount (Q) of the charged nanoparticles, may range from about 1 to about 600 μC/g, such as about 1 to about 100 μC/g, or
The core-first nanoparticle formation process allows the nanoparticle to include charge agent species in the shell. Because the shell is formed last, the shell species does not need to be as stable as it would if it were formed first and had to survive the core formation and cross-linking process. The hydrocarbon solvent used in previous shell-first nanoparticle formation methods also did not allow both micelle aggregation and polymerization of polar (charge agent) monomers. Thus, the core-first process can produce many new nanoparticles that were difficult or impossible to make with shell first processes.
While having long, uncrosslinked polymer chains in the shell may be beneficial in some applications, to preserve the charge and the durability of the nanoparticle, relatively short shell layer chain lengths are preferable for some applications. The longer the shell layer chain lengths become, the more susceptible they are to frictional shear forces and degradation. Accordingly, a relatively thin shell layer is preferable for some applications, such as for electronic displays. For example, the shell layer may be about 1 nm to about 100 nm, such as about 1 nm to about 50 nm, or about 1 nm to about 25 nm.
For certain applications such as QR-LPD display technologies, making both positively and negatively charged nanoparticles to be used in cells together is required. The methods and nanoparticles described herein are particularly well suited to controlling the polarity and the magnitude of a group of positive and negative particles. In an embodiment, a first group of nanoparticles and a second group of nanoparticles may have a difference in charge of about 50 μC/g or greater, such as about 50 to about 500 μC/g, or about 75 to about 200 μC/g.
The size of the entire core-shell nanoparticles, including both core and shell—expressed as a mean average diameter—are, for example, between about 5 and about 20,000 nanometers, such as about 50 to about 5,000 nanometers, about 75 to about 300 nanometers, or about 75 to about 150 nanometers.
For some applications the nanoparticles are preferably substantially monodisperse and uniform in shape. The nanoparticles may, for example, have a dispersity less than about 1.3, such as less than about 1.2, or less than about 1.1. Image analysis, such as SEM image analysis, or light scattering analysis of the particles can provide information for calculating the particle size distribution.
The highly cross-linked nature of the nanoparticles described herein enables them to have a highly spherical shape with few if any shape defects or irregularities. In one embodiment, about 90% to 100%, for example, about 92% to about 99%, or about 95% to about 98%, of the nanoparticles have no shape defects or irregularities. Furthermore, the sphericalness of the nanoparticles can be measured by measuring a first diameter (D₁) of a nanoparticle and then a second diameter (D₂) at a right angle to D₁. (D₁may be selected to be any diameter of the nanoparticle, and the measurements of D₁and D₂may be done by analysis of an SEM image.) Then dividing D₁by D₂will yield a number close to 1, for example about 0.9 to about 1.1, 0.95 to 1.05, or 0.97 to 1.03. Thus, a formula representing the sphericalness (s) of the nanoparticles may be stated as: D₁/D₂=s. In one embodiment, about 90% to 100%, for example, about 92% to about 99%, or about 95% to about 98%, of the nanoparticles have a sphericalness of about 0.9 to about 1.1.
Without being bound by theory, it is believed that nanoparticles that are highly spherical will be more durable in structural and charge characteristics than those that are not so spherical. This is due, in part, to the decreased frictional forces that act upon objects that are highly spherical. Shape defects are likely to cause structural failure or deformation of the nanoparticles.
In an embodiment the example nanoparticles are also substantially discrete, for example, the nanoparticles have about 20% to 0% cross-linking between nanoparticles, such as 9% to 0%, about 8% to about 2%, about 5% to about 0.1%, or about 3% to about 0.1%.
In an embodiment, the core of the synthesized nanoparticles is hard. For example, the core has a Tg of 100° C. or higher, such as 150° C. or higher. In an embodiment, the nanoparticles have a core that is relatively harder than the shell, for example, at least 60° C. higher than the Tg of the shell layer, or at least 1° C. higher than the Tg of the shell layer. In one example, the shell layer is soft. That is, the shell layer has a Tg lower than 0° C. In one embodiment, the Tg of the shell layer is between 0° C. and −100° C. In another embodiment the Tg of the shell is also high, such as 100° C. or higher, such as 150° C. or higher. Nanoparticles with hard cores and soft shells are particularly useful for reinforcing rubber compounds used for tire treads. Nanoparticles with hard cores and hard shells are particularly useful in electronic display applications such as QR-LPD.
The Tg of the polymers in the nanoparticles is influenced by the selection of monomers and their molecular weight, styrene content, and vinyl content. The degree of cross-linking also contributes to the Tg of the core and shell.
The following examples and tables are presented for purposes of illustration only and are not to be construed in a limiting sense.

EXAMPLES

A 0.8 liter nitrogen-purged glass bottle sealed with a septum liner and perforated crown cap was used as the reactor vessel for the examples below. Styrene (33 wt % in hexane), hexane, n-butyllithium (1.60 M in hexane), 2,2-bis(2′-tetrahydrofuryl)propane (1.60 M in hexane, stored over calcium hydride), potassium tert-amyloxide (KTA), and BHT solution in hexane were also used. PS-PB diblocks STEREON S730AC and STEREON S721 were obtained from Firestone Polymers. Commercially available reagents were obtained from Aldrich and Gelest Inc. (Morrisville, Pa.) and dried over molecular sieves (3 Å).

Examples A-D

Examples A-D were made by the method below. The only difference between examples A-D is the amount of DVB that was added.
To a 0.8 liter nitrogen-purged glass bottle was added 140 g of hexane, 60 g of 33 wt % styrene, varying amounts of DVB, 6 ml of 5 wt % STEREON S721, 0.4 ml of 1.6 M 2,2′-di(tetrahydrofuryl)propane (OOPS), and 2 ml of 1.6 M n-butyl lithium. The amount of DVB was added in the amounts shown in FIG. 1. The DVB % shown in FIG. 1 is a weight percent based on the total amount of DVB and monomer. The reaction mixture was stirred for one day at room temperature before terminating with 3 ml isopropanol. After the solvent evaporated, the products were dried in vacuum.
FIG. 1 graphically shows the yield of nanoparticles obtained compared to the varying amounts of DVB. The DVB was added all at once, and a single solvent system (hexane) was used. This data demonstrates that simply increasing the amount of DVB causes reduced yields.

Example 1

To a 0.8 liter nitrogen-purged glass bottle was added 140 g of hexane, 60 g of 33 wt % styrene, 10 ml of DVB, 6 ml of 5 wt % STEREON S721, 0.4 ml of 1.6 M 2,2′-di(tetrahydrofuryl)propane (OOPS), and 2 ml of 1.6 M n-butyl lithium. The reaction mixture was stirred for one day at room temperature before terminating with 3 ml isopropanol. After the solvent evaporated, the products were dried in vacuum.

Example 2

To a 0.8 liter nitrogen-purged glass bottle was added 300 g of hexane, 20 g of 33 wt % styrene, 0.1 ml of DVB, 1 ml of 5 wt % STEREON S721, 0.2 ml of 1.6 M 2,2′-di(tetrahydrofuryl)propane (OOPS), and 1 ml of 1.6 M n-butyl lithium. After 10 minutes, an additional 2.8 ml of DVB was added to the bottle. The reaction mixture was stirred for one day at room temperature before terminating with 3 ml of isopropanol. After the solvent evaporated, the products were dried in vacuum.

Example 3

To a 0.8 liter nitrogen-purged glass bottle was added 300 g of hexane, 20 g of 33 wt % styrene, 30 ml of THF, 0.3 ml of DVB, 1 ml of 5 wt % STEREON S721, 0.2 ml of 1.6 M 2,2′-di(tetrahydrofuryl)propane (OOPS), and 1 ml of 1.6 M n-butyl lithium. After 10 minutes, an additional 2.6 ml of DVB was added to the bottle. The reaction mixture was stirred for one day at room temperature before terminating with 3 ml of isopropanol. After the solvent evaporated, the products were dried in vacuum.

Example 4

To a 0.8 liter nitrogen-purged glass bottle was added 300 g of hexane, 20 g of 33 wt % styrene, 0.5 ml of DVB (50 wt % in hexane), 10 ml of 5 wt % STEREON S730AC, 0.06 ml of 1.6 M KTA and 0.5 ml of 1.6 M n-butyl lithium. After 10 minutes, an additional 9.5 ml of DVB (50 wt % in hexane) was added to the bottle. The reaction mixture was stirred for three days at room temperature. The products were coagulated with isopropanol, filtered, and dried in vacuum.

Example 5

To a 0.8 liter nitrogen-purged glass bottle was added 300 g of hexane, 20 g of 33 wt % styrene, 10 ml of THF, 0.5 ml of DVB (50 wt % in hexane), 10 ml of 5 wt % STEREON S730AC, 0.06 ml of 1.6 M KTA and 0.5 ml of 1.6 M n-butyl lithium. After 10 min, an additional 9.5 ml of DVB (50 wt % in hexane) was added to the bottle. The reaction mixture was stirred for three days at room temperature. The products were coagulated with isopropanol, filtered, and dried in vacuum.

Example 6

To a 0.8 liter nitrogen-purged glass bottle was added 300 g hexane, 20 g of 33 wt % styrene, 20 ml of THF, 0.5 ml of DVB (50 wt % in hexane), 10 ml of 5 wt % STEREON S730AC, 0.06 ml of 1.6 M KTA, and 0.5 ml of 1.6 M n-butyl lithium. After 10 min, an additional 9.5 ml DVB (50 wt % in hexane) was added to the bottle. The reaction mixture was stirred for three days at room temperature. The products were coagulated with isopropanol, filtered, and dried in vacuum.

TABLE 1

Example 1	Example 2	Example 3

St/DVB (wt/wt)	68/32	72/28	72/28
THF/Hexane	0	0	6%
(vol/vol)
1^st/2^ndDVB charge	10/0 ml	0.1/2.8 ml	0.3/2.6 ml
Yield (%)	42	87	98
Size (nm)	500-1000	500-800	400-600
SEM image	FIG. 2	FIG. 3	FIG. 4

TABLE 2

Example 4	Example 5	Example 6

St/DVB (wt/wt)	57/43	57/43	57/43
THF/Hexane	0	2%	4%
(vol/vol)
1^st/2^ndDVB charge	0.25/4.75 ml	0.25/4.75 ml	0.25/4.75 ml
Yield (%)	32	53	70
Size (nm)	80-120	50-140	80-100
SEM image	FIG. 5	FIG. 6	FIG. 7

The complex nature of the core-first dispersion polymerization process makes it difficult to reproducibly control the particle shape uniformity and size distribution. Increased content of styrene and DVB (crosslinking agent) in the anionic dispersion polymerization reduced the product yield and led to a gel. Table 1 shows the effect on the product yield of varying the DVB amount. In Examples 2-6 DVB was incrementally added to the bottle to prevent aggregation of highly crosslinked nanoparticles. The Examples show the effect of THF as a modifier and co-solvent as well. The results are summarized in Tables 1 and 2.
Incremental DVB addition increased not only the product yield but also improved the particle shape and size distribution. THF as a modifier and co-solvent accelerated the polymer chain propagation in the heterogeneous polymerization and activated the live ends of the core to swell and incorporate more monomer and cross-linking agent.
Furthermore, well-defined particles with high crosslinking density were obtained by balancing initiation, propagation, and particle formation in the presence of THF and the modifier such as OOPS or KTA.
This written description sets forth the best mode of the invention, and describes the invention so as to enable a person skilled in the art to make and use the invention, by presenting examples. The patentable scope of the invention is defined by the claims, and may include other examples that occur to those skilled in the art.

Claims

It is claimed:

1. Spherical cross-linked nanoparticles comprising:

a core formed from a polymeric seed that includes a mono-vinyl aromatic core species cross-linked with a cross-linking agent, the core having an average diameter of 5 nanometers to 10,000 nanometers;

wherein the mono-vinyl aromatic core species comprises polymeric chains radiating from a center of the core;

wherein the spherical cross-linked nanoparticles meet the following equation:

0.90≦(D1/D2)≦1.1

wherein D1 is a first diameter of the spherical cross-linked nanoparticles and D2 is a second diameter of the spherical cross-linked nanoparticles, and D1 and D2 intersect at right angles.

2. The spherical cross-linked nanoparticles of claim 1, wherein the polymer chains form a surface of the core and the surface of the core comprises living ends of the polymer chains.

3. The spherical cross-linked nanoparticles of claim 2, further comprising a shell layer bonded to the living ends of the surface, the shell layer comprising a fixed formal charge group.

4. The spherical cross-linked nanoparticles of claim 2, further comprising a shell layer bonded to the living ends of the surface, wherein the shell layer is about 1 nm to about 100 nm in thickness.

5. The spherical cross-linked nanoparticles of claim 2, wherein the surface of the nanoparticle comprises terminated living ends.

6. The spherical cross-linked nanoparticles of claim 1, wherein the cross-linking agent comprises 30% to 60% by weight of the combined weight of the mono-vinyl aromatic species and the cross-linking agent.

7. Cross-linked nanoparticles comprising:

wherein the weight ratio of mono-vinyl monomer species to total cross-linking agent ranges from about 30:70 to about 90:10;

wherein the nanoparticles meet the following equation:

0.90≦(D1/D2)≦1.1

wherein D1 is a first diameter of the cross-linked nanoparticles and D2 is a second diameter of the spherical cross-linked nanoparticles, and D1 and D2 intersect at right angles.

8. The spherical cross-linked nanoparticles of claim 1, with the proviso that the spherical cross-linked nanoparticles are not made by emulsion polymerization.

9. The spherical cross-linked nanoparticles of claim 1, wherein the nanoparticles are made by the process comprising:

combining a hydrocarbon solvent and an aprotic, polar co-solvent, a mono-vinyl aromatic monomer, polymerization initiator, a solution stabilizer, and a first charge of a cross-linking agent;

adding a second charge of the cross-linking agent or a charge of another cross-linking agent;

wherein the spherical cross-linked nanoparticles have an average diameter of 5 nanometers to about 10,000 nanometers;

wherein a volume ratio of hydrocarbon solvent to aprotic, polar co-solvent ranges from about 99.9:0.1 to about 70:30.

10. The spherical cross-linked nanoparticles of claim 3, wherein the fixed formal charge group is selected from at least one of the group consisting of: succinic anhydride, imidazole, pyridines, N,N-dimethylaminostyrene, N,N-diethylaminostyrene, pyridine silane, vinyl pyridine and derivates of these, quaternary ammonium compounds, quaternary phosphonium compounds, and quaternary sulfonium compounds.

11. The spherical cross-linked nanoparticles of claim 1, wherein the spherical cross-linked nanoparticles comprise a first group of spherical cross-linked nanoparticles and a second group of spherical cross-linked nanoparticles, wherein the first and second group have a difference in charge of about 50 μC/g or greater.

12. The spherical cross-linked nanoparticles of claim 1, wherein for a given collection of the spherical cross-linked nanoparticles measured by an SEM, 90% to 100% of the nanoparticle group meets the following equation:

0.90≦(D1/D2)≦1.1

13. The spherical cross-linked nanoparticles of claim 1, wherein the spherical cross-linked nanoparticles comprise a shell bonded to the core, the shell including polymerized monomers, wherein the core has a higher Tg than the shell.

14. The cross-linked nanoparticles of claim 7, further comprising a shell layer bonded to the surface of the core, the shell layer comprising a fixed formal charge group.

15. The cross-linked nanoparticles of claim 14, wherein the fixed formal charge group is selected from at least one of the group consisting of: succinic anhydride, imidazole, pyridines, N,N-dimethylaminostyrene, N,N-diethylaminostyrene, pyridine silane, vinyl pyridine and derivates of these, quaternary ammonium compounds, quaternary phosphonium compounds, and quaternary sulfonium compounds.

16. The cross-linked nanoparticles of claim 7, wherein the cross-linked nanoparticles comprise a first group of cross-linked nanoparticles and a second group of cross-linked nanoparticles, wherein the first and second group have a difference in charge of about 50 μC/g or greater.

17. The cross-linked nanoparticles of claim 7, wherein for a given collection of the cross-linked nanoparticles measured by an SEM, 90% to 100% of the nanoparticle group meets the following equation:

0.90≦(D1/D2)≦1.1

wherein D1 is a first diameter of the cross-linked nanoparticles and D2 is a second diameter of the cross-linked nanoparticles, and D1 and D2 intersect at right angles.

18. The cross-linked nanoparticles of claim 7, wherein the cross-linked nanoparticles comprise a shell bonded to the core, the shell including polymerized monomers, wherein the core has a higher Tg than the shell.

19. The cross-linked nanoparticles of claim 16, wherein the first group of cross-linked nanoparticles has a positive charge and the second group of cross-linked nanoparticles has a negative charge.

20. The spherical cross-linked nanoparticles of claim 11, wherein the first group of spherical cross-linked nanoparticles has a positive charge and the second group of spherical cross-linked nanoparticles has a negative charge.