US20140163025A1 - Indanyloxydihydrobenzofuranylacetic acids - Google Patents
Indanyloxydihydrobenzofuranylacetic acids Download PDFInfo
- Publication number
- US20140163025A1 US20140163025A1 US14/093,583 US201314093583A US2014163025A1 US 20140163025 A1 US20140163025 A1 US 20140163025A1 US 201314093583 A US201314093583 A US 201314093583A US 2014163025 A1 US2014163025 A1 US 2014163025A1
- Authority
- US
- United States
- Prior art keywords
- alkyl
- group
- yloxy
- fluoro
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 COC1=CC=C(F)C2=C1CC[C@H]2OC1=CC=C2C(=C1)OC[C@H]2CC(=O)O.[1*]C Chemical compound COC1=CC=C(F)C2=C1CC[C@H]2OC1=CC=C2C(=C1)OC[C@H]2CC(=O)O.[1*]C 0.000 description 25
- OVYCCVRANDEMOG-LYZGTLIUSA-N CC(C)(O)CCCC1=CC(C#N)=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 Chemical compound CC(C)(O)CCCC1=CC(C#N)=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 OVYCCVRANDEMOG-LYZGTLIUSA-N 0.000 description 2
- VIDVHFGOAIIAIS-KBMIEXCESA-N CC(C)(O)CCCC1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)N=C1 Chemical compound CC(C)(O)CCCC1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)N=C1 VIDVHFGOAIIAIS-KBMIEXCESA-N 0.000 description 2
- AREKJWZDGYKTBM-XHCCPWGMSA-N CC(C)(O)CCN1/N=C\C2=C1C=CC(OC1=CC=C(F)C3=C1CC[C@H]3OC1=CC=C3C(=C1)OC[C@H]3CC(=O)O)=C2 Chemical compound CC(C)(O)CCN1/N=C\C2=C1C=CC(OC1=CC=C(F)C3=C1CC[C@H]3OC1=CC=C3C(=C1)OC[C@H]3CC(=O)O)=C2 AREKJWZDGYKTBM-XHCCPWGMSA-N 0.000 description 2
- ORGIZLVKZRNGLN-UHFFFAOYSA-N CC(C)(O)CN1C=C(C2=CC(F)=C(O)C(F)=C2)C=N1 Chemical compound CC(C)(O)CN1C=C(C2=CC(F)=C(O)C(F)=C2)C=N1 ORGIZLVKZRNGLN-UHFFFAOYSA-N 0.000 description 2
- YBPKXBZWXASPMS-NFQMXDRXSA-N CC1=CC(OCCC(C)(C)O)=CC(C)=C1OC1=C2CC[C@@H](OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C2=C(F)C=C1 Chemical compound CC1=CC(OCCC(C)(C)O)=CC(C)=C1OC1=C2CC[C@@H](OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C2=C(F)C=C1 YBPKXBZWXASPMS-NFQMXDRXSA-N 0.000 description 2
- CWHCJKTYQDBOQK-ONOMSOESSA-N CC1=CC=CC(C2=CC=C(OC3=C4CC[C@@H](OC5=CC=C6C(=C5)OC[C@H]6CC(=O)O)C4=C(F)C=C3)C(C#N)=C2)=N1 Chemical compound CC1=CC=CC(C2=CC=C(OC3=C4CC[C@@H](OC5=CC=C6C(=C5)OC[C@H]6CC(=O)O)C4=C(F)C=C3)C(C#N)=C2)=N1 CWHCJKTYQDBOQK-ONOMSOESSA-N 0.000 description 2
- XSRFUKLTPHFFQA-IQGLISFBSA-N CC1=NC=C(C2=CC=C(OC3=C4CC[C@@H](OC5=CC=C6C(=C5)OC[C@H]6CC(=O)O)C4=C(F)C=C3)C=C2)S1 Chemical compound CC1=NC=C(C2=CC=C(OC3=C4CC[C@@H](OC5=CC=C6C(=C5)OC[C@H]6CC(=O)O)C4=C(F)C=C3)C=C2)S1 XSRFUKLTPHFFQA-IQGLISFBSA-N 0.000 description 2
- HNMMMZXIACIPBI-IQGLISFBSA-N CCNC(=O)C1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)OC)C3=C(F)C=C2)C=C1 Chemical compound CCNC(=O)C1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)OC)C3=C(F)C=C2)C=C1 HNMMMZXIACIPBI-IQGLISFBSA-N 0.000 description 2
- GUSFBVCPKMHDJH-PIGZYNQJSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(B(O)O)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(B(O)O)C=CC(F)=C43)=CC=C21 GUSFBVCPKMHDJH-PIGZYNQJSA-N 0.000 description 2
- ASRPHKAOMRROKV-CRICUBBOSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC6=C(C=C5)CCC(=O)N6)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC6=C(C=C5)CCC(=O)N6)C=CC(F)=C43)=CC=C21 ASRPHKAOMRROKV-CRICUBBOSA-N 0.000 description 2
- QAMWZIPFBCUUEC-IQMFZBJNSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(Br)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(Br)C=C5)C=CC(F)=C43)=CC=C21 QAMWZIPFBCUUEC-IQMFZBJNSA-N 0.000 description 2
- AWMALUOMFQFXGV-PIGZYNQJSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4O)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4O)=CC=C21 AWMALUOMFQFXGV-PIGZYNQJSA-N 0.000 description 2
- WWECFVCBTJYYSQ-PIIWDFAUSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(C4=CC=NN4C)C=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(C4=CC=NN4C)C=C3)=CC=C21 WWECFVCBTJYYSQ-PIIWDFAUSA-N 0.000 description 2
- JTUWHFSJNXBDGO-YKGWIAGDSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(OCC4=CC=CC=C4)C=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(OCC4=CC=CC=C4)C=C3)=CC=C21 JTUWHFSJNXBDGO-YKGWIAGDSA-N 0.000 description 2
- UGXLGZFNBUIAEA-CRICUBBOSA-N COCCOC1=CC=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 Chemical compound COCCOC1=CC=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 UGXLGZFNBUIAEA-CRICUBBOSA-N 0.000 description 2
- XZNMIGVKEVYDDK-WGDIFIGCSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(OC6CCOCC6)=CC=C5F)C=CC(F)=C43)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(OC6CCOCC6)=CC=C5F)C=CC(F)=C43)=CC=C21 XZNMIGVKEVYDDK-WGDIFIGCSA-N 0.000 description 2
- XPRKYIFHEVZCOT-NIYFSFCBSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C(=O)N6CCCC6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C(=O)N6CCCC6)C=C5)C=CC(F)=C43)=CC=C21 XPRKYIFHEVZCOT-NIYFSFCBSA-N 0.000 description 2
- QBMXWPKFPLXUTM-MZNJEOGPSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NC=CS6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NC=CS6)C=C5)C=CC(F)=C43)=CC=C21 QBMXWPKFPLXUTM-MZNJEOGPSA-N 0.000 description 2
- VRSMHBRLGPELOJ-NFQMXDRXSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(CN6CCCC6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(CN6CCCC6)C=C5)C=CC(F)=C43)=CC=C21 VRSMHBRLGPELOJ-NFQMXDRXSA-N 0.000 description 2
- BDROZRMKQHELSJ-LNZPYGSCSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(O[C@H]6CCOC6)C=N5)C=CC(F)=C43)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(O[C@H]6CCOC6)C=N5)C=CC(F)=C43)=CC=C21 BDROZRMKQHELSJ-LNZPYGSCSA-N 0.000 description 2
- VSVWIENLUIXJPI-UHFFFAOYSA-N C1=CC2=CC=CN2C=C1.C1=CC2=CC=CN2N=C1.C1=CC2=CC=NN2C=C1.C1=CC2=CN=CN2C=C1.C1=CC2=CNC=C2C=C1.C1=CC2=NC=CN2C=C1.C1=CC2=NC=CN2C=N1.C1=CC2=NC=NN2C=C1.C1=CC2=NN=CN2C=C1.C1=CN2C=CN=C2C=N1.C1=CN2CCCC2=C1.C1=NC=C2NC=NC2=C1 Chemical compound C1=CC2=CC=CN2C=C1.C1=CC2=CC=CN2N=C1.C1=CC2=CC=NN2C=C1.C1=CC2=CN=CN2C=C1.C1=CC2=CNC=C2C=C1.C1=CC2=NC=CN2C=C1.C1=CC2=NC=CN2C=N1.C1=CC2=NC=NN2C=C1.C1=CC2=NN=CN2C=C1.C1=CN2C=CN=C2C=N1.C1=CN2CCCC2=C1.C1=NC=C2NC=NC2=C1 VSVWIENLUIXJPI-UHFFFAOYSA-N 0.000 description 1
- LWSUMLBCRDBYFZ-UHFFFAOYSA-N C1=CC2=CC=NC=C2N1.C1=CC2=CN=CC=C2N1.C1=CC2=NON=C2C=C1.C1=CC2=NSN=C2C=C1.C1=CC=C2NC=CC2=C1.C1=CC=C2NC=NC2=C1.C1=CC=C2NN=CC2=C1.C1=CC=C2NN=NC2=C1.C1=CC=C2OC=CC2=C1.C1=CC=C2OC=NC2=C1.C1=CC=C2ON=CC2=C1.C1=CC=C2SC=CC2=C1.C1=CC=C2SC=NC2=C1.C1=CC=C2SN=CC2=C1.C1=CC=NC=C1.C1=CCC=C1.C1=CCN=C1.C1=CN=C2C=CNC2=C1.C1=CN=C2NC=CC2=C1.C1=CN=C2NC=NC2=C1.C1=CN=C2NN=CC2=C1.C1=CN=CC1.C1=CN=CC=N1.C1=CN=CN=C1.C1=CN=NC1.C1=CN=NC=C1.C1=COC=C1.C1=COC=N1.C1=CON=C1.C1=CON=N1.C1=CSC=C1.C1=CSC=N1.C1=CSN=C1.C1=CSN=N1.C1=NC=C2NC=NC2=C1.C1=NC=C2NC=NC2=N1.C1=NC=NC=N1.C1=NC=NN=C1.C1=NC=NO1.C1=NC=NS1.C1=NN=CC1.C1=NN=CO1.C1=NN=CS1.C1=NN=NC1.C1=NON=C1.C1=NSN=C1.O=S1(=O)C=CC2=CC=CC=C21.O=S1(=O)C=CC=C1.O=S1C=CC2=CC=CC=C21.O=S1C=CC=C1.[O-][N+]1=CC=CC=C1 Chemical compound C1=CC2=CC=NC=C2N1.C1=CC2=CN=CC=C2N1.C1=CC2=NON=C2C=C1.C1=CC2=NSN=C2C=C1.C1=CC=C2NC=CC2=C1.C1=CC=C2NC=NC2=C1.C1=CC=C2NN=CC2=C1.C1=CC=C2NN=NC2=C1.C1=CC=C2OC=CC2=C1.C1=CC=C2OC=NC2=C1.C1=CC=C2ON=CC2=C1.C1=CC=C2SC=CC2=C1.C1=CC=C2SC=NC2=C1.C1=CC=C2SN=CC2=C1.C1=CC=NC=C1.C1=CCC=C1.C1=CCN=C1.C1=CN=C2C=CNC2=C1.C1=CN=C2NC=CC2=C1.C1=CN=C2NC=NC2=C1.C1=CN=C2NN=CC2=C1.C1=CN=CC1.C1=CN=CC=N1.C1=CN=CN=C1.C1=CN=NC1.C1=CN=NC=C1.C1=COC=C1.C1=COC=N1.C1=CON=C1.C1=CON=N1.C1=CSC=C1.C1=CSC=N1.C1=CSN=C1.C1=CSN=N1.C1=NC=C2NC=NC2=C1.C1=NC=C2NC=NC2=N1.C1=NC=NC=N1.C1=NC=NN=C1.C1=NC=NO1.C1=NC=NS1.C1=NN=CC1.C1=NN=CO1.C1=NN=CS1.C1=NN=NC1.C1=NON=C1.C1=NSN=C1.O=S1(=O)C=CC2=CC=CC=C21.O=S1(=O)C=CC=C1.O=S1C=CC2=CC=CC=C21.O=S1C=CC=C1.[O-][N+]1=CC=CC=C1 LWSUMLBCRDBYFZ-UHFFFAOYSA-N 0.000 description 1
- QVKSFCACRKIYGA-UHFFFAOYSA-N C1=CC=C(COC2=CC3=C(C=C2)CC=C3)C=C1.CC(C)(O)CCN1C=CC2=C1C=CC(O)=C2.CC(C)(O)CCN1C=CC2=C1C=CC(OCC1=CC=CC=C1)=C2 Chemical compound C1=CC=C(COC2=CC3=C(C=C2)CC=C3)C=C1.CC(C)(O)CCN1C=CC2=C1C=CC(O)=C2.CC(C)(O)CCN1C=CC2=C1C=CC(OCC1=CC=CC=C1)=C2 QVKSFCACRKIYGA-UHFFFAOYSA-N 0.000 description 1
- IHOJAXFHQGUISV-UHFFFAOYSA-N C1=CC=C(COC2=CC3=C(C=C2)CN=C3)C=C1.CC(C)(O)CCN1N=CC2=C1C=CC(O)=C2.CC(C)(O)CCN1N=CC2=C1C=CC(OCC1=CC=CC=C1)=C2 Chemical compound C1=CC=C(COC2=CC3=C(C=C2)CN=C3)C=C1.CC(C)(O)CCN1N=CC2=C1C=CC(O)=C2.CC(C)(O)CCN1N=CC2=C1C=CC(OCC1=CC=CC=C1)=C2 IHOJAXFHQGUISV-UHFFFAOYSA-N 0.000 description 1
- ZDCDJYFKGUXDEU-CHWNLMKGSA-N C1CC2CCCC(C1)B2CC1CCOCC1.C=C1CCOCC1.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(Br)C=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(CC4CCOCC4)C=C3)=CC=C21 Chemical compound C1CC2CCCC(C1)B2CC1CCOCC1.C=C1CCOCC1.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(Br)C=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(CC4CCOCC4)C=C3)=CC=C21 ZDCDJYFKGUXDEU-CHWNLMKGSA-N 0.000 description 1
- UETGAQUHXJDUMK-ILABGHTRSA-N C=CC1=CC(C#N)=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)OC)C=C1.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(Br)C=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(C=O)C=C3)=CC=C21 Chemical compound C=CC1=CC(C#N)=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)OC)C=C1.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(Br)C=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(C=O)C=C3)=CC=C21 UETGAQUHXJDUMK-ILABGHTRSA-N 0.000 description 1
- KGUALWIZKWTQND-ZOGOHQQZSA-N C=CCC(C)(C)O.CC(C)(O)CCCB1C2CCCC1CCC2.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3/C(F)=C\C=C/4OC3=CC=C(Br)C=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3/C(F)=C\C=C/4OC3=CC=C(CCCC(C)(C)O)C=C3)=CC=C21 Chemical compound C=CCC(C)(C)O.CC(C)(O)CCCB1C2CCCC1CCC2.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3/C(F)=C\C=C/4OC3=CC=C(Br)C=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3/C(F)=C\C=C/4OC3=CC=C(CCCC(C)(C)O)C=C3)=CC=C21 KGUALWIZKWTQND-ZOGOHQQZSA-N 0.000 description 1
- QVELNQWCNROAGZ-VOIUYBSRSA-N CC(=O)NC1=CC(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)=CC=C1 Chemical compound CC(=O)NC1=CC(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)=CC=C1 QVELNQWCNROAGZ-VOIUYBSRSA-N 0.000 description 1
- ASJKKHRQZWCINT-VOIUYBSRSA-N CC(=O)NC1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 Chemical compound CC(=O)NC1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 ASJKKHRQZWCINT-VOIUYBSRSA-N 0.000 description 1
- SHKCBRNSTJWXFI-IQGLISFBSA-N CC(=O)NCC1=CC=CC(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)=C1 Chemical compound CC(=O)NCC1=CC=CC(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)=C1 SHKCBRNSTJWXFI-IQGLISFBSA-N 0.000 description 1
- NVLBGTSBRVJBSQ-IEGCZIGGSA-N CC(C)(C)[Si](C)(C)OC1=C(C#N)C=C(B(O)O)C=C1.CC(C)(C)[Si](C)(C)OC1=C(C#N)C=C(Br)C=C1.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(O)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(C#N)=C(O)C=C5)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(C#N)=C(O[Si](C)(C)C(C)(C)C)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound CC(C)(C)[Si](C)(C)OC1=C(C#N)C=C(B(O)O)C=C1.CC(C)(C)[Si](C)(C)OC1=C(C#N)C=C(Br)C=C1.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(O)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(C#N)=C(O)C=C5)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(C#N)=C(O[Si](C)(C)C(C)(C)C)C=C5)C=CC(F)=C43)=CC=C21 NVLBGTSBRVJBSQ-IEGCZIGGSA-N 0.000 description 1
- UOWWYLPFEMWLKO-NFQMXDRXSA-N CC(C)(O)CCC1=CC(C#N)=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 Chemical compound CC(C)(O)CCC1=CC(C#N)=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 UOWWYLPFEMWLKO-NFQMXDRXSA-N 0.000 description 1
- NIHKWXQJTHMDIE-QQYMHGPISA-N CC(C)(O)CCC1=CC=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1.CC(C)(O)CN1N=NC(C2=C(F)C=C(OC3=CC=C(F)C4=C3CC[C@H]4OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C=C2F)=N1.CC1=NN(C2=C(F)C=C(OC3=CC=C(F)C4=C3CC[C@H]4OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C=C2F)C=C1.CC1=NN(C2=C(F)C=C(OC3=CC=C(F)C4=C3CC[C@H]4OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C=C2F)C=N1.CS(=O)(=O)CCCOC1=CC(F)=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1.O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(F)C=C(OCC4(O)CCOCC4)C=C3)=CC=C21 Chemical compound CC(C)(O)CCC1=CC=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1.CC(C)(O)CN1N=NC(C2=C(F)C=C(OC3=CC=C(F)C4=C3CC[C@H]4OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C=C2F)=N1.CC1=NN(C2=C(F)C=C(OC3=CC=C(F)C4=C3CC[C@H]4OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C=C2F)C=C1.CC1=NN(C2=C(F)C=C(OC3=CC=C(F)C4=C3CC[C@H]4OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C=C2F)C=N1.CS(=O)(=O)CCCOC1=CC(F)=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1.O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(F)C=C(OCC4(O)CCOCC4)C=C3)=CC=C21 NIHKWXQJTHMDIE-QQYMHGPISA-N 0.000 description 1
- XFFJHNVZSKUCRX-JIPXPUAJSA-N CC(C)(O)CCCC1=CC(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)=C(C#N)C=C1 Chemical compound CC(C)(O)CCCC1=CC(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)=C(C#N)C=C1 XFFJHNVZSKUCRX-JIPXPUAJSA-N 0.000 description 1
- ARYDZEZHNQBWNQ-NFQMXDRXSA-N CC(C)(O)CCCC1=CC=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 Chemical compound CC(C)(O)CCCC1=CC=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 ARYDZEZHNQBWNQ-NFQMXDRXSA-N 0.000 description 1
- BNFAOBRHCSILCA-PIIWDFAUSA-N CC(C)(O)CCCN1N=CC2=C1C=C(OC1=CC=C(F)C3=C1CC[C@H]3OC1=CC=C3C(=C1)OC[C@H]3CC(=O)O)C=C2 Chemical compound CC(C)(O)CCCN1N=CC2=C1C=C(OC1=CC=C(F)C3=C1CC[C@H]3OC1=CC=C3C(=C1)OC[C@H]3CC(=O)O)C=C2 BNFAOBRHCSILCA-PIIWDFAUSA-N 0.000 description 1
- HALGSUPWGOWPQG-PIIWDFAUSA-N CC(C)(O)CCN1/C=C\C2=C1C=CC(OC1=CC=C(F)C3=C1CC[C@H]3OC1=CC=C3C(=C1)OC[C@H]3CC(=O)O)=C2 Chemical compound CC(C)(O)CCN1/C=C\C2=C1C=CC(OC1=CC=C(F)C3=C1CC[C@H]3OC1=CC=C3C(=C1)OC[C@H]3CC(=O)O)=C2 HALGSUPWGOWPQG-PIIWDFAUSA-N 0.000 description 1
- KFPNWNHTEDDIMO-UHFFFAOYSA-N CC(C)(O)CCN1N=CC2=C1C=C(O)C=C2.CC(C)(O)CCN1N=CC2=C1C=C(OCC1=CC=CC=C1)C=C2.OC1=CC2=C(C=C1)C=NC2 Chemical compound CC(C)(O)CCN1N=CC2=C1C=C(O)C=C2.CC(C)(O)CCN1N=CC2=C1C=C(OCC1=CC=CC=C1)C=C2.OC1=CC2=C(C=C1)C=NC2 KFPNWNHTEDDIMO-UHFFFAOYSA-N 0.000 description 1
- OIEQWXBVPJPWRF-XHCCPWGMSA-N CC(C)(O)CCOC1=C(C#N)C=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 Chemical compound CC(C)(O)CCOC1=C(C#N)C=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 OIEQWXBVPJPWRF-XHCCPWGMSA-N 0.000 description 1
- VBGYZOMININTRO-JNZLWJHCSA-N CC(C)(O)CCOC1=C(C#N)C=CC(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)=C1.CC(C)(O)CCOC1=C(F)C=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1.N#CC1=C(OC2CCOC2)C=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1.O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(F)C=C(OC4CCOC4)C(F)=C3)=CC=C21.O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(F)C=C(OC4CCOCC4)C(F)=C3)=CC=C21 Chemical compound CC(C)(O)CCOC1=C(C#N)C=CC(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)=C1.CC(C)(O)CCOC1=C(F)C=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1.N#CC1=C(OC2CCOC2)C=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1.O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(F)C=C(OC4CCOC4)C(F)=C3)=CC=C21.O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(F)C=C(OC4CCOCC4)C(F)=C3)=CC=C21 VBGYZOMININTRO-JNZLWJHCSA-N 0.000 description 1
- CBEYUIJZKSXVTP-UHFFFAOYSA-N CC(C)(O)CCOC1=CC(F)=C(B2OC(C)(C)C(C)(C)O2)C=C1F.CC(C)(O)CCOC1=CC(F)=C(Br)C=C1F.CC(C)(O)CCOC1=CC(F)=C(O)C=C1F.OC1=CC(F)=C(Br)C=C1F Chemical compound CC(C)(O)CCOC1=CC(F)=C(B2OC(C)(C)C(C)(C)O2)C=C1F.CC(C)(O)CCOC1=CC(F)=C(Br)C=C1F.CC(C)(O)CCOC1=CC(F)=C(O)C=C1F.OC1=CC(F)=C(Br)C=C1F CBEYUIJZKSXVTP-UHFFFAOYSA-N 0.000 description 1
- YYTQLVKETPPUGS-VOIUYBSRSA-N CC(C)(O)CCOC1=CC(F)=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1F Chemical compound CC(C)(O)CCOC1=CC(F)=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1F YYTQLVKETPPUGS-VOIUYBSRSA-N 0.000 description 1
- YBQPYVVILPRISG-NIYFSFCBSA-N CC(C)(O)CCOC1=CC(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)=C(C#N)C=C1 Chemical compound CC(C)(O)CCOC1=CC(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)=C(C#N)C=C1 YBQPYVVILPRISG-NIYFSFCBSA-N 0.000 description 1
- RXICZTOJZMYHHI-CRICUBBOSA-N CC(C)(O)CCOC1=CC=C(F)C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)=C1 Chemical compound CC(C)(O)CCOC1=CC=C(F)C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)=C1 RXICZTOJZMYHHI-CRICUBBOSA-N 0.000 description 1
- IZOAMFOTMPCTER-XHCCPWGMSA-N CC(C)(O)CCOC1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C(C#N)=C1 Chemical compound CC(C)(O)CCOC1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C(C#N)=C1 IZOAMFOTMPCTER-XHCCPWGMSA-N 0.000 description 1
- DRURJBIXOPCBAG-WGDIFIGCSA-N CC(C)(O)CCOC1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C(F)=C1 Chemical compound CC(C)(O)CCOC1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C(F)=C1 DRURJBIXOPCBAG-WGDIFIGCSA-N 0.000 description 1
- JETNYVZGIZXOEH-WXTAPIANSA-N CC(C)(O)CCOC1=CC=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 Chemical compound CC(C)(O)CCOC1=CC=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 JETNYVZGIZXOEH-WXTAPIANSA-N 0.000 description 1
- LINKCCKRNBRDIU-UHFFFAOYSA-N CC(C)(O)CCOC1=CN=C(F)C=C1 Chemical compound CC(C)(O)CCOC1=CN=C(F)C=C1 LINKCCKRNBRDIU-UHFFFAOYSA-N 0.000 description 1
- ZZBZOAUNJJLOGR-MZNJEOGPSA-N CC(C)(O)CCOC1=CN=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 Chemical compound CC(C)(O)CCOC1=CN=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 ZZBZOAUNJJLOGR-MZNJEOGPSA-N 0.000 description 1
- GCHUQHKHUFMWDH-UHFFFAOYSA-N CC(C)(O)CN1C=C(B2OC(C)(C)C(C)(C)O2)C=N1 Chemical compound CC(C)(O)CN1C=C(B2OC(C)(C)C(C)(C)O2)C=N1 GCHUQHKHUFMWDH-UHFFFAOYSA-N 0.000 description 1
- NUTYMIWRJJHLFJ-UHFFFAOYSA-N CC(C)(O)CN1C=C(C2=C(F)C=C(B(O)O)C=C2F)C=N1 Chemical compound CC(C)(O)CN1C=C(C2=C(F)C=C(B(O)O)C=C2F)C=N1 NUTYMIWRJJHLFJ-UHFFFAOYSA-N 0.000 description 1
- GSKQXXJAOLKYHI-UHFFFAOYSA-N CC(C)(O)CN1C=C(C2=C(F)C=C(B3OC(C)(C)C(C)(C)O3)C=C2F)C=N1 Chemical compound CC(C)(O)CN1C=C(C2=C(F)C=C(B3OC(C)(C)C(C)(C)O3)C=C2F)C=N1 GSKQXXJAOLKYHI-UHFFFAOYSA-N 0.000 description 1
- CCCQDYBQKZAMHM-UHFFFAOYSA-N CC(C)(O)CN1C=C(C2=C(F)C=C(O)C=C2F)C=N1 Chemical compound CC(C)(O)CN1C=C(C2=C(F)C=C(O)C=C2F)C=N1 CCCQDYBQKZAMHM-UHFFFAOYSA-N 0.000 description 1
- GTEYRYGSBRZUNX-XGCWNURASA-N CC(C)(O)CN1C=C(C2=C(F)C=C(OC3=C4CC[C@@H](OC5=CC=C6C(=C5)OC[C@H]6CC(=O)O)C4=C(F)C=C3)C=C2F)C=N1 Chemical compound CC(C)(O)CN1C=C(C2=C(F)C=C(OC3=C4CC[C@@H](OC5=CC=C6C(=C5)OC[C@H]6CC(=O)O)C4=C(F)C=C3)C=C2F)C=N1 GTEYRYGSBRZUNX-XGCWNURASA-N 0.000 description 1
- FOOAUCMOUMCBNZ-XGCWNURASA-N CC(C)(O)CN1C=C(C2=C(F)C=C(OC3=CC=C(F)C4=C3CC[C@H]4OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C(F)=C2)C=N1 Chemical compound CC(C)(O)CN1C=C(C2=C(F)C=C(OC3=CC=C(F)C4=C3CC[C@H]4OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C(F)=C2)C=N1 FOOAUCMOUMCBNZ-XGCWNURASA-N 0.000 description 1
- QOWMEIGLYJNFLH-UHFFFAOYSA-N CC(C)(O)CN1C=C(C2=C(F)C=C(OS(=O)(=O)C(F)(F)F)C=C2F)C=N1 Chemical compound CC(C)(O)CN1C=C(C2=C(F)C=C(OS(=O)(=O)C(F)(F)F)C=C2F)C=N1 QOWMEIGLYJNFLH-UHFFFAOYSA-N 0.000 description 1
- WYFTTYJPBWEZKW-UHFFFAOYSA-N CC(C)(O)CN1C=C(C2=CC(F)=C(O)C=C2F)C=N1 Chemical compound CC(C)(O)CN1C=C(C2=CC(F)=C(O)C=C2F)C=N1 WYFTTYJPBWEZKW-UHFFFAOYSA-N 0.000 description 1
- MXOUZSGTOSXDFG-DNOBIOAJSA-N CC(C)(O)CN1C=C(C2=CC(F)=C(OC3=CC=C(F)C4=C3CC[C@H]4OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C(F)=C2)C=N1 Chemical compound CC(C)(O)CN1C=C(C2=CC(F)=C(OC3=CC=C(F)C4=C3CC[C@H]4OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C(F)=C2)C=N1 MXOUZSGTOSXDFG-DNOBIOAJSA-N 0.000 description 1
- MCTRHJWCHIFAOJ-IQGLISFBSA-N CC(C)(O)COC1=C(C#N)C=CC(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)=C1 Chemical compound CC(C)(O)COC1=C(C#N)C=CC(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)=C1 MCTRHJWCHIFAOJ-IQGLISFBSA-N 0.000 description 1
- UCZHJNHGLALSAX-CRICUBBOSA-N CC(C)(O)COC1=CC=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 Chemical compound CC(C)(O)COC1=CC=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 UCZHJNHGLALSAX-CRICUBBOSA-N 0.000 description 1
- IESXBMRVMUKOGH-JLTOFOAXSA-N CC(C)C1=CC=CC2=C1CC[C@H]2OC1=CC=C2C(=C1)OC[C@H]2CC(=O)O Chemical compound CC(C)C1=CC=CC2=C1CC[C@H]2OC1=CC=C2C(=C1)OC[C@H]2CC(=O)O IESXBMRVMUKOGH-JLTOFOAXSA-N 0.000 description 1
- ISWXBLLHIWFULD-UHFFFAOYSA-N CC1(C)OB(C2=C(F)C=C(OCCCS(C)(=O)=O)C(F)=C2)OC1(C)C.CS(=O)(=O)CCCOC1=CC(F)=C(Br)C=C1F.CS(=O)(=O)CCCOC1=CC(F)=C(O)C=C1F.CSCCCOC1=C(F)C=C(Br)C(F)=C1.OC1=CC(F)=C(Br)C=C1F Chemical compound CC1(C)OB(C2=C(F)C=C(OCCCS(C)(=O)=O)C(F)=C2)OC1(C)C.CS(=O)(=O)CCCOC1=CC(F)=C(Br)C=C1F.CS(=O)(=O)CCCOC1=CC(F)=C(O)C=C1F.CSCCCOC1=C(F)C=C(Br)C(F)=C1.OC1=CC(F)=C(Br)C=C1F ISWXBLLHIWFULD-UHFFFAOYSA-N 0.000 description 1
- JDJDQCNMCGDHQD-UHFFFAOYSA-N CC1(C)OB(C2=CC(F)=C(OCCCS(C)(=O)=O)C(F)=C2)OC1(C)C Chemical compound CC1(C)OB(C2=CC(F)=C(OCCCS(C)(=O)=O)C(F)=C2)OC1(C)C JDJDQCNMCGDHQD-UHFFFAOYSA-N 0.000 description 1
- LEOMIKOMAGRHOA-WVXBCFDCSA-N CC1=CC(C2=CC=C(OC3=C4CC[C@@H](OC5=CC=C6C(=C5)OC[C@H]6CC(=O)O)C4=C(F)C=C3)C(C#N)=C2)=CC(C)=N1 Chemical compound CC1=CC(C2=CC=C(OC3=C4CC[C@@H](OC5=CC=C6C(=C5)OC[C@H]6CC(=O)O)C4=C(F)C=C3)C(C#N)=C2)=CC(C)=N1 LEOMIKOMAGRHOA-WVXBCFDCSA-N 0.000 description 1
- ONDBQWMFRKENTC-ONOMSOESSA-N CC1=CC(C2=CC=C(OC3=C4CC[C@@H](OC5=CC=C6C(=C5)OC[C@H]6CC(=O)O)C4=C(F)C=C3)C(F)=C2)=CC(C)=N1 Chemical compound CC1=CC(C2=CC=C(OC3=C4CC[C@@H](OC5=CC=C6C(=C5)OC[C@H]6CC(=O)O)C4=C(F)C=C3)C(F)=C2)=CC(C)=N1 ONDBQWMFRKENTC-ONOMSOESSA-N 0.000 description 1
- MBUVENKGFFKLTL-UHFFFAOYSA-N CC1=CC2=C(C=C1)C=NN2.CC1=CC2=C(C=C1)NN=C2 Chemical compound CC1=CC2=C(C=C1)C=NN2.CC1=CC2=C(C=C1)NN=C2 MBUVENKGFFKLTL-UHFFFAOYSA-N 0.000 description 1
- UEXQDTQZTQZJJK-UHFFFAOYSA-N CC1=CC2=C(C=C1)C=NN2.CC1=CC2=C(C=C1)NN=C2.CC1=CC=CC=C1.CC1=CC=NC=C1.CC1=CN=CC=C1.CC1=NC=CC=C1 Chemical compound CC1=CC2=C(C=C1)C=NN2.CC1=CC2=C(C=C1)NN=C2.CC1=CC=CC=C1.CC1=CC=NC=C1.CC1=CN=CC=C1.CC1=NC=CC=C1 UEXQDTQZTQZJJK-UHFFFAOYSA-N 0.000 description 1
- RGCFRLLKPQCEBR-UHFFFAOYSA-N CC1=CC2=C(C=C1)OCC2.CC1=CC=C(C2=CC(C)=NC(C)=C2)C=C1.CC1=CC=C(C2=CN(C)N=N2)C=C1.CC1=CC=C(C2=CSC(C)=N2)C=C1.CC1=CC=C(C2=NC(C)=CC=C2)C=C1.CC1=CC=C(C2=NC(C)=NO2)C=C1.CC1=CC=C(C2=NN(C)C(C)=N2)C=C1.CC1=CC=C(C2=NN(CC(C)(C)O)N=N2)C=C1.CC1=CC=C(C2=NN=N(C)N2)C=C1.CC1=CC=C(C2=NN=NN2C)C=C1.CC1=CC=C(C2=NOC(C)=N2)C=C1.CC1=CC=C(N2C=NC(C)=N2)C=C1 Chemical compound CC1=CC2=C(C=C1)OCC2.CC1=CC=C(C2=CC(C)=NC(C)=C2)C=C1.CC1=CC=C(C2=CN(C)N=N2)C=C1.CC1=CC=C(C2=CSC(C)=N2)C=C1.CC1=CC=C(C2=NC(C)=CC=C2)C=C1.CC1=CC=C(C2=NC(C)=NO2)C=C1.CC1=CC=C(C2=NN(C)C(C)=N2)C=C1.CC1=CC=C(C2=NN(CC(C)(C)O)N=N2)C=C1.CC1=CC=C(C2=NN=N(C)N2)C=C1.CC1=CC=C(C2=NN=NN2C)C=C1.CC1=CC=C(C2=NOC(C)=N2)C=C1.CC1=CC=C(N2C=NC(C)=N2)C=C1 RGCFRLLKPQCEBR-UHFFFAOYSA-N 0.000 description 1
- QFDOMDVHDUEJNN-WHLCRQNOSA-N CC1=CC=CC(C2=CC=C(OC3=C4CC[C@@H](OC5=CC=C6C(=C5)OC[C@H]6CC(=O)O)C4=C(F)C=C3)C(F)=C2)=N1 Chemical compound CC1=CC=CC(C2=CC=C(OC3=C4CC[C@@H](OC5=CC=C6C(=C5)OC[C@H]6CC(=O)O)C4=C(F)C=C3)C(F)=C2)=N1 QFDOMDVHDUEJNN-WHLCRQNOSA-N 0.000 description 1
- YXFVVABEGXRONW-UHFFFAOYSA-N CC1=CC=CC=C1 Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
- HOYXTFVMLYHNTC-UHFFFAOYSA-N CC1=CC=NC=C1.CC1=CN=CC=C1.CC1=NC=CC=C1 Chemical compound CC1=CC=NC=C1.CC1=CN=CC=C1.CC1=NC=CC=C1 HOYXTFVMLYHNTC-UHFFFAOYSA-N 0.000 description 1
- WMDHXJQRZLOFMD-WXTAPIANSA-N CC1=NC(C2=CC=C(OC3=C4CC[C@@H](OC5=CC=C6C(=C5)OC[C@H]6CC(=O)O)C4=C(F)C=C3)C=C2)=CS1 Chemical compound CC1=NC(C2=CC=C(OC3=C4CC[C@@H](OC5=CC=C6C(=C5)OC[C@H]6CC(=O)O)C4=C(F)C=C3)C=C2)=CS1 WMDHXJQRZLOFMD-WXTAPIANSA-N 0.000 description 1
- KMDKUDLCQJHZCT-XIBCFNFTSA-N CC1=NC(C2=CC=C(OC3=CC=C(F)C4=C3CC[C@H]4OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C=C2)=NN1C.CC1=NC(C2=CC=C(OC3=CC=C(F)C4=C3CC[C@H]4OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C=C2)=NO1.CC1=NOC(C2=CC=C(OC3=CC=C(F)C4=C3CC[C@H]4OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C=C2)=N1.N#CC1=C(OCC2(O)CCOCC2)C=CC(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)=C1.O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(C4=NC=CO4)C=C3)=CC=C21 Chemical compound CC1=NC(C2=CC=C(OC3=CC=C(F)C4=C3CC[C@H]4OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C=C2)=NN1C.CC1=NC(C2=CC=C(OC3=CC=C(F)C4=C3CC[C@H]4OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C=C2)=NO1.CC1=NOC(C2=CC=C(OC3=CC=C(F)C4=C3CC[C@H]4OC3=CC=C4C(=C3)OC[C@H]4CC(=O)O)C=C2)=N1.N#CC1=C(OCC2(O)CCOCC2)C=CC(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)=C1.O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(C4=NC=CO4)C=C3)=CC=C21 KMDKUDLCQJHZCT-XIBCFNFTSA-N 0.000 description 1
- OKWVKGQPTXIZMU-NFQMXDRXSA-N CC1=NOC(C)=C1C1=CC(C#N)=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 Chemical compound CC1=NOC(C)=C1C1=CC(C#N)=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 OKWVKGQPTXIZMU-NFQMXDRXSA-N 0.000 description 1
- IUJJBZKHGUNNNV-WXTAPIANSA-N CC1=NOC(C)=C1C1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C(F)=C1 Chemical compound CC1=NOC(C)=C1C1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C(F)=C1 IUJJBZKHGUNNNV-WXTAPIANSA-N 0.000 description 1
- XCLGETSFVUYSAP-UHFFFAOYSA-N CCC(C)(C)C.CCC(C)C.CCC1CC1 Chemical compound CCC(C)(C)C.CCC(C)C.CCC1CC1 XCLGETSFVUYSAP-UHFFFAOYSA-N 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N CCCCC(=O)O Chemical compound CCCCC(=O)O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- ZWQVGDOKFJDHTD-MZNJEOGPSA-N CCNC(=O)C1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 Chemical compound CCNC(=O)C1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 ZWQVGDOKFJDHTD-MZNJEOGPSA-N 0.000 description 1
- OLZUKVMRMZKCTL-MZNJEOGPSA-N CN(C)C(=O)C1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 Chemical compound CN(C)C(=O)C1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 OLZUKVMRMZKCTL-MZNJEOGPSA-N 0.000 description 1
- MKXYHSYCLSWJTR-IQGLISFBSA-N CN1C=CN=C1C1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 Chemical compound CN1C=CN=C1C1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 MKXYHSYCLSWJTR-IQGLISFBSA-N 0.000 description 1
- NBUIKTJXKJMTQP-XHCCPWGMSA-N CN1N=CC=C1C1=CC(C#N)=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 Chemical compound CN1N=CC=C1C1=CC(C#N)=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 NBUIKTJXKJMTQP-XHCCPWGMSA-N 0.000 description 1
- UDXXAOZWAGVLLE-WGDIFIGCSA-N CN1N=CC=C1C1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C(F)=C1 Chemical compound CN1N=CC=C1C1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C(F)=C1 UDXXAOZWAGVLLE-WGDIFIGCSA-N 0.000 description 1
- PVERUTLCDVOZFZ-WAIKUNEKSA-N CN1N=NC(C2=CC=C(OC3=C4CC[C@@H](OC5=CC=C6C(=C5)OC[C@H]6CC(=O)O)C4=C(F)C=C3)C=C2)=N1 Chemical compound CN1N=NC(C2=CC=C(OC3=C4CC[C@@H](OC5=CC=C6C(=C5)OC[C@H]6CC(=O)O)C4=C(F)C=C3)C=C2)=N1 PVERUTLCDVOZFZ-WAIKUNEKSA-N 0.000 description 1
- RUVLYOCHEIANKB-WAIKUNEKSA-N CN1N=NN=C1C1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 Chemical compound CN1N=NN=C1C1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 RUVLYOCHEIANKB-WAIKUNEKSA-N 0.000 description 1
- CVLWPPPIGDHKCJ-AZOMMZINSA-N COC(=O)CC1=COC2=CC(O)=CC=C12.COC(=O)C[C@@H]1COC2=CC(O)=CC=C21.COC(=O)C[C@H]1COC2=CC(O)=CC=C21.O=C(O)CC1=COC2=CC(O)=CC=C12 Chemical compound COC(=O)CC1=COC2=CC(O)=CC=C12.COC(=O)C[C@@H]1COC2=CC(O)=CC=C21.COC(=O)C[C@H]1COC2=CC(O)=CC=C21.O=C(O)CC1=COC2=CC(O)=CC=C12 CVLWPPPIGDHKCJ-AZOMMZINSA-N 0.000 description 1
- AGCVMGUYEPDTLU-HFJWLAOPSA-N COC(=O)C[C@@H]1CCC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC4=C(C=C3)OCCO4)=CC=C21 Chemical compound COC(=O)C[C@@H]1CCC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC4=C(C=C3)OCCO4)=CC=C21 AGCVMGUYEPDTLU-HFJWLAOPSA-N 0.000 description 1
- OMLLLVHIALYSLX-YOHZGAGBSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(B(O)O)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=C(F)C=C(B6OC(C)(C)C(C)(C)O6)C=C5)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=C(F)C=C(Br)C=C5)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=C(F)C=C(O)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(B(O)O)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=C(F)C=C(B6OC(C)(C)C(C)(C)O6)C=C5)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=C(F)C=C(Br)C=C5)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=C(F)C=C(O)C=C5)C=CC(F)=C43)=CC=C21 OMLLLVHIALYSLX-YOHZGAGBSA-N 0.000 description 1
- LPEPEHZWOPEUMK-CDIVOJTMSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(B(O)O)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(B6OC(C)(C)C(C)(C)O6)=CC=C5F)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(Br)=CC=C5F)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(O)=CC=C5F)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(B(O)O)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(B6OC(C)(C)C(C)(C)O6)=CC=C5F)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(Br)=CC=C5F)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(O)=CC=C5F)C=CC(F)=C43)=CC=C21 LPEPEHZWOPEUMK-CDIVOJTMSA-N 0.000 description 1
- CADBFTZVYDARTA-OQKBBBDMSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(B(O)O)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(O)C=C5C#N)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(OCC6=CC=CC=C6)C=C5C#N)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(B(O)O)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(O)C=C5C#N)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(OCC6=CC=CC=C6)C=C5C#N)C=CC(F)=C43)=CC=C21 CADBFTZVYDARTA-OQKBBBDMSA-N 0.000 description 1
- BDMCOWRHBJJFDY-ULJOLZDESA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(O)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C(=O)O)C=C5)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C(=O)OCC6=CC=CC=C6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(O)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C(=O)O)C=C5)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C(=O)OCC6=CC=CC=C6)C=C5)C=CC(F)=C43)=CC=C21 BDMCOWRHBJJFDY-ULJOLZDESA-N 0.000 description 1
- JCDRJKWBXKCPTA-LYZGTLIUSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=C(C)C=C(OCCC(C)(C)O)C=C5C)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=C(C)C=C(OCCC(C)(C)O)C=C5C)C=CC(F)=C43)=CC=C21 JCDRJKWBXKCPTA-LYZGTLIUSA-N 0.000 description 1
- BWVZYPKJGKKHSS-SPLOXXLWSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(Br)=NC=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(Br)=NC=C5)C=CC(F)=C43)=CC=C21 BWVZYPKJGKKHSS-SPLOXXLWSA-N 0.000 description 1
- AVZBFORENDMKKZ-PIIWDFAUSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(C#N)=C(OCCC(C)(C)O)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(C#N)=C(OCCC(C)(C)O)C=C5)C=CC(F)=C43)=CC=C21 AVZBFORENDMKKZ-PIIWDFAUSA-N 0.000 description 1
- IMOWHXJONQNDSR-RPAZBDDQSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(C#N)=C(O[C@@H]6CCOC6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(C#N)=C(O[C@@H]6CCOC6)C=C5)C=CC(F)=C43)=CC=C21 IMOWHXJONQNDSR-RPAZBDDQSA-N 0.000 description 1
- IQYODQCBHAHFGF-NIYFSFCBSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(CNC(C)=O)=CC=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(CNC(C)=O)=CC=C5)C=CC(F)=C43)=CC=C21 IQYODQCBHAHFGF-NIYFSFCBSA-N 0.000 description 1
- QZYKJPZUZNJRPV-KWMCUTETSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(F)=C(C6=CN(CC(C)(C)O)N=C6)C(F)=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(F)=C(C6=CN(CC(C)(C)O)N=C6)C(F)=C5)C=CC(F)=C43)=CC=C21 QZYKJPZUZNJRPV-KWMCUTETSA-N 0.000 description 1
- PODSIGFFUBVAFM-WHLCRQNOSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(F)=C(OCC6(O)CCOCC6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(F)=C(OCC6(O)CCOCC6)C=C5)C=CC(F)=C43)=CC=C21 PODSIGFFUBVAFM-WHLCRQNOSA-N 0.000 description 1
- UUDFHAAEYWMRFX-WGDIFIGCSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(F)=C(OCCCS(C)(=O)=O)C(F)=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(F)=C(OCCCS(C)(=O)=O)C(F)=C5)C=CC(F)=C43)=CC=C21 UUDFHAAEYWMRFX-WGDIFIGCSA-N 0.000 description 1
- METXRTIPFNRJPZ-PIIWDFAUSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(OC6CCOCC6)=C(C#N)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(OC6CCOCC6)=C(C#N)C=C5)C=CC(F)=C43)=CC=C21 METXRTIPFNRJPZ-PIIWDFAUSA-N 0.000 description 1
- RDHBEEUQLRYRIL-NIYFSFCBSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(OCC(C)(C)O)=C(C#N)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(OCC(C)(C)O)=C(C#N)C=C5)C=CC(F)=C43)=CC=C21 RDHBEEUQLRYRIL-NIYFSFCBSA-N 0.000 description 1
- NALBLDLJOCIQSZ-WXTAPIANSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(OCCC(C)(C)O)=CC=C5F)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(OCCC(C)(C)O)=CC=C5F)C=CC(F)=C43)=CC=C21 NALBLDLJOCIQSZ-WXTAPIANSA-N 0.000 description 1
- CGBQLBKPWMMSGZ-HUJREVKFSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(O[C@H]6CCOC6)=NC=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(O[C@H]6CCOC6)=NC=C5)C=CC(F)=C43)=CC=C21 CGBQLBKPWMMSGZ-HUJREVKFSA-N 0.000 description 1
- FYPSANBBLPFRQC-CRICUBBOSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC6=C(C=C5)OCC6)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC6=C(C=C5)OCC6)C=CC(F)=C43)=CC=C21 FYPSANBBLPFRQC-CRICUBBOSA-N 0.000 description 1
- NOYKIQSHPUIFPQ-IJMPGPTRSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(/C=C/CC(C)(C)O)C=N5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(/C=C/CC(C)(C)O)C=N5)C=CC(F)=C43)=CC=C21 NOYKIQSHPUIFPQ-IJMPGPTRSA-N 0.000 description 1
- CGBMUBWEXWEQTF-KFUSUHJHSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(B6OC(C)(C)C(C)(C)O6)C=C5C#N)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(Br)C=C5C#N)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=CC(C)=NC(C)=C6)C=C5C#N)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(B6OC(C)(C)C(C)(C)O6)C=C5C#N)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(Br)C=C5C#N)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=CC(C)=NC(C)=C6)C=C5C#N)C=CC(F)=C43)=CC=C21 CGBMUBWEXWEQTF-KFUSUHJHSA-N 0.000 description 1
- ZQOZUYSTQMIVMX-IQGLISFBSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C(=O)N(C)C)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C(=O)N(C)C)C=C5)C=CC(F)=C43)=CC=C21 ZQOZUYSTQMIVMX-IQGLISFBSA-N 0.000 description 1
- LZNFVCQIOKMMQG-NFQMXDRXSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C(=O)N6CCCC6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C(=O)N6CCCC6)C=C5)C=CC(F)=C43)=CC=C21 LZNFVCQIOKMMQG-NFQMXDRXSA-N 0.000 description 1
- WYGXEGPNNCVVCV-NFQMXDRXSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C(=O)N6CCOCC6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C(=O)N6CCOCC6)C=C5)C=CC(F)=C43)=CC=C21 WYGXEGPNNCVVCV-NFQMXDRXSA-N 0.000 description 1
- QOZAIMWNWJVSQD-XHCCPWGMSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=C(C)ON=C6C)C=C5F)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=C(C)ON=C6C)C=C5F)C=CC(F)=C43)=CC=C21 QOZAIMWNWJVSQD-XHCCPWGMSA-N 0.000 description 1
- QIOYLMBCPSYMOF-YKGWIAGDSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=CC(C)=NC(C)=C6)C=C5F)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=CC(C)=NC(C)=C6)C=C5F)C=CC(F)=C43)=CC=C21 QIOYLMBCPSYMOF-YKGWIAGDSA-N 0.000 description 1
- KTXILDBNKMZTQG-DNOBIOAJSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=CC=NN6C)C=C5F)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=CC=NN6C)C=C5F)C=CC(F)=C43)=CC=C21 KTXILDBNKMZTQG-DNOBIOAJSA-N 0.000 description 1
- HXQKPYFRMXPBQU-NIYFSFCBSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=CN=C(C)S6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=CN=C(C)S6)C=C5)C=CC(F)=C43)=CC=C21 HXQKPYFRMXPBQU-NIYFSFCBSA-N 0.000 description 1
- ISOLBJBUYPPWME-YKGWIAGDSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NC(C)=CC=C6)C=C5C#N)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NC(C)=CC=C6)C=C5C#N)C=CC(F)=C43)=CC=C21 ISOLBJBUYPPWME-YKGWIAGDSA-N 0.000 description 1
- ZPJRYRMJMNFQMO-ACSYHNTCSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NC(C)=CC=C6)C=C5F)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NC(C)=CC=C6)C=C5F)C=CC(F)=C43)=CC=C21 ZPJRYRMJMNFQMO-ACSYHNTCSA-N 0.000 description 1
- YOWLRUUSJWUFCV-NIYFSFCBSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NC=CN6C)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NC=CN6C)C=C5)C=CC(F)=C43)=CC=C21 YOWLRUUSJWUFCV-NIYFSFCBSA-N 0.000 description 1
- SEEHZTXBLJXAIQ-IQGLISFBSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NC=CS6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NC=CS6)C=C5)C=CC(F)=C43)=CC=C21 SEEHZTXBLJXAIQ-IQGLISFBSA-N 0.000 description 1
- CRFWHUHKCRBLMT-ZLXKXLKESA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NN(C)N=N6)C=C5)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NN=NN6C)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NN(C)N=N6)C=C5)C=CC(F)=C43)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NN=NN6C)C=C5)C=CC(F)=C43)=CC=C21 CRFWHUHKCRBLMT-ZLXKXLKESA-N 0.000 description 1
- SKEJPEYFYXYXHV-CRICUBBOSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NN=NC6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NN=NC6)C=C5)C=CC(F)=C43)=CC=C21 SKEJPEYFYXYXHV-CRICUBBOSA-N 0.000 description 1
- BNWYOOBSLMQELJ-IQGLISFBSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(CC#N)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(CC#N)C=C5)C=CC(F)=C43)=CC=C21 BNWYOOBSLMQELJ-IQGLISFBSA-N 0.000 description 1
- BFFYFORIYWJTCM-NIYFSFCBSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(CCC#N)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(CCC#N)C=C5)C=CC(F)=C43)=CC=C21 BFFYFORIYWJTCM-NIYFSFCBSA-N 0.000 description 1
- WYKKUDZWKSARDB-FQRUVTKNSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(CCCC(C)(C)O)C=N5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(CCCC(C)(C)O)C=N5)C=CC(F)=C43)=CC=C21 WYKKUDZWKSARDB-FQRUVTKNSA-N 0.000 description 1
- GBGCLXRBPZGARB-LYZGTLIUSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(CN6CCCC6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(CN6CCCC6)C=C5)C=CC(F)=C43)=CC=C21 GBGCLXRBPZGARB-LYZGTLIUSA-N 0.000 description 1
- CZUVPEDXGOQACV-LYZGTLIUSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(CN6CCOCC6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(CN6CCOCC6)C=C5)C=CC(F)=C43)=CC=C21 CZUVPEDXGOQACV-LYZGTLIUSA-N 0.000 description 1
- PEGIMIKBTVZESJ-SPLOXXLWSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(I)C=N5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(I)C=N5)C=CC(F)=C43)=CC=C21 PEGIMIKBTVZESJ-SPLOXXLWSA-N 0.000 description 1
- WOGOVXQXKFZBIK-WXTAPIANSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(N6C=CN=C6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(N6C=CN=C6)C=C5)C=CC(F)=C43)=CC=C21 WOGOVXQXKFZBIK-WXTAPIANSA-N 0.000 description 1
- YIHGCOFCEZKANS-WXTAPIANSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(N6CCCC6=O)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(N6CCCC6=O)C=C5)C=CC(F)=C43)=CC=C21 YIHGCOFCEZKANS-WXTAPIANSA-N 0.000 description 1
- SEOYNAIEYWGSDO-CRICUBBOSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(NC(C)=O)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(NC(C)=O)C=C5)C=CC(F)=C43)=CC=C21 SEOYNAIEYWGSDO-CRICUBBOSA-N 0.000 description 1
- GREBPSLSLYKTSV-KWMCUTETSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(OC6CCOCC6)C=C5F)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(OC6CCOCC6)C=C5F)C=CC(F)=C43)=CC=C21 GREBPSLSLYKTSV-KWMCUTETSA-N 0.000 description 1
- QGCJUONFSMPCKM-PIIWDFAUSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(OCCC(C)(C)O)C=C5C#N)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(OCCC(C)(C)O)C=C5C#N)C=CC(F)=C43)=CC=C21 QGCJUONFSMPCKM-PIIWDFAUSA-N 0.000 description 1
- TZWQUPATJQDFFD-DNOBIOAJSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(OCCC(C)(C)O)C=C5F)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(OCCC(C)(C)O)C=C5F)C=CC(F)=C43)=CC=C21 TZWQUPATJQDFFD-DNOBIOAJSA-N 0.000 description 1
- FZIRLZSRQAPVHL-HUJREVKFSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(O[C@H]6CCOC6)C=N5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(O[C@H]6CCOC6)C=N5)C=CC(F)=C43)=CC=C21 FZIRLZSRQAPVHL-HUJREVKFSA-N 0.000 description 1
- LALFEEJQCVGOBM-WXTAPIANSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=CC(N6CCCC6=O)=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=CC(N6CCCC6=O)=C5)C=CC(F)=C43)=CC=C21 LALFEEJQCVGOBM-WXTAPIANSA-N 0.000 description 1
- CWNGCMLSRXQHQV-CRICUBBOSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=CC(NC(C)=O)=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=CC(NC(C)=O)=C5)C=CC(F)=C43)=CC=C21 CWNGCMLSRXQHQV-CRICUBBOSA-N 0.000 description 1
- ODMRODITGCTMFW-IQGLISFBSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=NC=C(OCCC(C)(C)O)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=NC=C(OCCC(C)(C)O)C=C5)C=CC(F)=C43)=CC=C21 ODMRODITGCTMFW-IQGLISFBSA-N 0.000 description 1
- PCPSJMDGCUZYPU-PYOKGTDMSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3/C(F)=C\C=C/4OC3=CC=C(Br)C=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3/C(F)=C\C=C/4OC3=CC=C(C4=CCOCC4)C=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3/C(F)=C\C=C/4OC3=CC=C(C4CCOCC4)C=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3/C(F)=C\C=C/4OC3=CC=C(Br)C=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3/C(F)=C\C=C/4OC3=CC=C(C4=CCOCC4)C=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3/C(F)=C\C=C/4OC3=CC=C(C4CCOCC4)C=C3)=CC=C21 PCPSJMDGCUZYPU-PYOKGTDMSA-N 0.000 description 1
- WBXVUMWZIGUPLI-MZNJEOGPSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3/C(F)=C\C=C/4OC3=CC=C(C#N)C=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3/C(F)=C\C=C/4OC3=CC=C(C#N)C=C3)=CC=C21 WBXVUMWZIGUPLI-MZNJEOGPSA-N 0.000 description 1
- OGDZJPZRJHCHFG-WXTAPIANSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3/C(F)=C\C=C/4OC3=CC=C(OCC(C)(C)O)C=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3/C(F)=C\C=C/4OC3=CC=C(OCC(C)(C)O)C=C3)=CC=C21 OGDZJPZRJHCHFG-WXTAPIANSA-N 0.000 description 1
- PVKJMMIQENJFEB-XHCCPWGMSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3/C(F)=C\C=C/4OC3=CC=C(OCCCS(C)(=O)=O)C=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3/C(F)=C\C=C/4OC3=CC=C(OCCCS(C)(=O)=O)C=C3)=CC=C21 PVKJMMIQENJFEB-XHCCPWGMSA-N 0.000 description 1
- ZLUJCQBGUAAGMQ-CAVGWFEXSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4B(O)O)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC(F)=C(O)C=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC(F)=C(OCC4=CC=CC=C4)C=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4B(O)O)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC(F)=C(O)C=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC(F)=C(OCC4=CC=CC=C4)C=C3)=CC=C21 ZLUJCQBGUAAGMQ-CAVGWFEXSA-N 0.000 description 1
- YFPCQNXHUYRMKT-QVKFZJNVSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4B3OC(C)(C)C(C)(C)O3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4B3OC(C)(C)C(C)(C)O3)=CC=C21 YFPCQNXHUYRMKT-QVKFZJNVSA-N 0.000 description 1
- VSQNITFCEFODMF-PIGZYNQJSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4Br)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4Br)=CC=C21 VSQNITFCEFODMF-PIGZYNQJSA-N 0.000 description 1
- FQPDRGAWDLMWPM-PRHFKSMYSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4O)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=CC(Br)=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=CC(CCCC(C)(C)O)=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4O)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=CC(Br)=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=CC(CCCC(C)(C)O)=C3)=CC=C21 FQPDRGAWDLMWPM-PRHFKSMYSA-N 0.000 description 1
- GDKRUXAKLKCAME-VHAVFGROSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(/C=C/C(C)(C)O)C=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(Br)C=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(CCC(C)(C)O)C=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(/C=C/C(C)(C)O)C=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(Br)C=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(CCC(C)(C)O)C=C3)=CC=C21 GDKRUXAKLKCAME-VHAVFGROSA-N 0.000 description 1
- YUAHTZLEDDPFJN-VOIUYBSRSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(Br)C=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(Br)C=C3)=CC=C21 YUAHTZLEDDPFJN-VOIUYBSRSA-N 0.000 description 1
- YVDUGYINUOTXST-LYZGTLIUSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(C4=C(C)ON=C4C)C=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(C4=C(C)ON=C4C)C=C3)=CC=C21 YVDUGYINUOTXST-LYZGTLIUSA-N 0.000 description 1
- JQCQIEWJOFNZGY-KPURRNSFSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(CCCC(C)(C)O)C=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(CCCC(C)(C)O)C=C3)=CC=C21 JQCQIEWJOFNZGY-KPURRNSFSA-N 0.000 description 1
- UWDAXIKMFXZOOS-WVXBCFDCSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(CN4CCCCC4)C=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(CN4CCCCC4)C=C3)=CC=C21 UWDAXIKMFXZOOS-WVXBCFDCSA-N 0.000 description 1
- QMJYZNMXDCRSKV-KPURRNSFSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(CN4CCOCC4)C=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=C(CN4CCOCC4)C=C3)=CC=C21 QMJYZNMXDCRSKV-KPURRNSFSA-N 0.000 description 1
- NYAINQVIRWTXAM-BUFXPRQVSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=CC(B4OC(C)(C)C(C)(C)O4)=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=CC(Br)=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=CC(O)=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=CC(B4OC(C)(C)C(C)(C)O4)=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=CC(Br)=C3)=CC=C21.COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=CC(O)=C3)=CC=C21 NYAINQVIRWTXAM-BUFXPRQVSA-N 0.000 description 1
- AXUUMIXEAHJWPX-NFQMXDRXSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=CC(OCCC(C)(C)O)=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(C#N)C=CC(OCCC(C)(C)O)=C3)=CC=C21 AXUUMIXEAHJWPX-NFQMXDRXSA-N 0.000 description 1
- CTBUDVPQUGXJGW-CRICUBBOSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(F)C=C(OCCC(C)(C)O)C(F)=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(F)C=C(OCCC(C)(C)O)C(F)=C3)=CC=C21 CTBUDVPQUGXJGW-CRICUBBOSA-N 0.000 description 1
- ZTCKZPFMENXMDH-CRICUBBOSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(F)C=C(OCCCS(C)(=O)=O)C(F)=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(F)C=C(OCCCS(C)(=O)=O)C(F)=C3)=CC=C21 ZTCKZPFMENXMDH-CRICUBBOSA-N 0.000 description 1
- YEDQKPZLHQRDBC-OVSRVKATSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC(F)=C(C4C=NN(CC(C)(C)O)=C4)C=C3F)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC(F)=C(C4C=NN(CC(C)(C)O)=C4)C=C3F)=CC=C21 YEDQKPZLHQRDBC-OVSRVKATSA-N 0.000 description 1
- RSODPAJOHPFJHQ-PIIWDFAUSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC4=C(C=C3)C=NN4CCC(C)(C)O)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC4=C(C=C3)C=NN4CCC(C)(C)O)=CC=C21 RSODPAJOHPFJHQ-PIIWDFAUSA-N 0.000 description 1
- JLJVYUYSJVYQFP-ONOMSOESSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC4=C(C=C3)N(CCC(C)(C)O)C=C4)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC4=C(C=C3)N(CCC(C)(C)O)C=C4)=CC=C21 JLJVYUYSJVYQFP-ONOMSOESSA-N 0.000 description 1
- ZOAWIWJSJLKKIC-PIIWDFAUSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC4=C(C=C3)N(CCC(C)(C)O)N=C4)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC4=C(C=C3)N(CCC(C)(C)O)N=C4)=CC=C21 ZOAWIWJSJLKKIC-PIIWDFAUSA-N 0.000 description 1
- YPRCQLPTYVFUEK-IQMFZBJNSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC4=C(C=C3)OCO4)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC4=C(C=C3)OCO4)=CC=C21 YPRCQLPTYVFUEK-IQMFZBJNSA-N 0.000 description 1
- RVHJUFBNZBUFGE-XHCCPWGMSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(C4=CSC(C)=N4)C=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(C4=CSC(C)=N4)C=C3)=CC=C21 RVHJUFBNZBUFGE-XHCCPWGMSA-N 0.000 description 1
- ZCRHFDUXHNWOSN-IQMFZBJNSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(O)C=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(O)C=C3)=CC=C21 ZCRHFDUXHNWOSN-IQMFZBJNSA-N 0.000 description 1
- CZLIWQUFQNCELY-XHCCPWGMSA-N COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(OCCC(C)(C)O)C=C3)=CC=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(OCCC(C)(C)O)C=C3)=CC=C21 CZLIWQUFQNCELY-XHCCPWGMSA-N 0.000 description 1
- SEMSNBQIDXQXOD-NCPUNKGMSA-N COC(=O)C[C@@H]1COC2=CC=C(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(F)C=C(C4C=NN(CC(C)(C)O)=C4)C=C3F)C=C21 Chemical compound COC(=O)C[C@@H]1COC2=CC=C(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C(F)C=C(C4C=NN(CC(C)(C)O)=C4)C=C3F)C=C21 SEMSNBQIDXQXOD-NCPUNKGMSA-N 0.000 description 1
- LFICWBKWVWJNNR-KPURRNSFSA-N COC(C[C@H](COc1c2)c1ccc2O[C@H](CC1)c2c1c(Oc1ccc(CC3CCOCC3)cc1)ccc2F)=O Chemical compound COC(C[C@H](COc1c2)c1ccc2O[C@H](CC1)c2c1c(Oc1ccc(CC3CCOCC3)cc1)ccc2F)=O LFICWBKWVWJNNR-KPURRNSFSA-N 0.000 description 1
- KHBSXOZZSVUOOH-WXTAPIANSA-N COCCOC1=CC=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)OC)C=C1 Chemical compound COCCOC1=CC=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)OC)C=C1 KHBSXOZZSVUOOH-WXTAPIANSA-N 0.000 description 1
- NDQWWAHWDBOVMK-UHFFFAOYSA-N CS(=O)(=O)CCCOC1=C(F)C=C(B(O)O)C=C1F Chemical compound CS(=O)(=O)CCCOC1=C(F)C=C(B(O)O)C=C1F NDQWWAHWDBOVMK-UHFFFAOYSA-N 0.000 description 1
- OSHPQUMGAGOUQB-UHFFFAOYSA-N CS(=O)(=O)CCCOC1=C(F)C=C(Br)C=C1F Chemical compound CS(=O)(=O)CCCOC1=C(F)C=C(Br)C=C1F OSHPQUMGAGOUQB-UHFFFAOYSA-N 0.000 description 1
- IAHOIQHVRXFUSX-PUAOIOHZSA-N CS(=O)(=O)CCCOC1=C(F)C=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1F Chemical compound CS(=O)(=O)CCCOC1=C(F)C=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1F IAHOIQHVRXFUSX-PUAOIOHZSA-N 0.000 description 1
- BGNHUBCSSZOYCN-VOIUYBSRSA-N CS(=O)(=O)CCCOC1=CC(F)=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1F Chemical compound CS(=O)(=O)CCCOC1=CC(F)=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1F BGNHUBCSSZOYCN-VOIUYBSRSA-N 0.000 description 1
- DODJAGVYLDJLIU-WXTAPIANSA-N CS(=O)(=O)CCCOC1=CC=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 Chemical compound CS(=O)(=O)CCCOC1=CC=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=C1 DODJAGVYLDJLIU-WXTAPIANSA-N 0.000 description 1
- CGCHCLICSHIAAM-UHFFFAOYSA-N Ic(cc1)cc2c1[nH]nc2 Chemical compound Ic(cc1)cc2c1[nH]nc2 CGCHCLICSHIAAM-UHFFFAOYSA-N 0.000 description 1
- RSGAXJZKQDNFEP-UHFFFAOYSA-N Ic1cc([nH]nc2)c2cc1 Chemical compound Ic1cc([nH]nc2)c2cc1 RSGAXJZKQDNFEP-UHFFFAOYSA-N 0.000 description 1
- HKEVGZKCJQEVPD-KPURRNSFSA-N N#CC1=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=CC(CN2CCCCC2)=C1 Chemical compound N#CC1=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=CC(CN2CCCCC2)=C1 HKEVGZKCJQEVPD-KPURRNSFSA-N 0.000 description 1
- DMBFIKQUOIHSDG-LYZGTLIUSA-N N#CC1=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=CC(CN2CCOCC2)=C1 Chemical compound N#CC1=C(OC2=CC=C(F)C3=C2CC[C@H]3OC2=CC=C3C(=C2)OC[C@H]3CC(=O)O)C=CC(CN2CCOCC2)=C1 DMBFIKQUOIHSDG-LYZGTLIUSA-N 0.000 description 1
- CJEIAAQUPBRICO-XHCCPWGMSA-N N#CC1=C(OC2CCOCC2)C=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 Chemical compound N#CC1=C(OC2CCOCC2)C=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 CJEIAAQUPBRICO-XHCCPWGMSA-N 0.000 description 1
- IARUSWPTHJOUSV-UBUJSBSDSA-N N#CC1=C(O[C@@H]2CCOC2)C=CC(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)=C1 Chemical compound N#CC1=C(O[C@@H]2CCOC2)C=CC(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)=C1 IARUSWPTHJOUSV-UBUJSBSDSA-N 0.000 description 1
- ALLGYQCYCLBXGQ-MZNJEOGPSA-N N#CCC1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 Chemical compound N#CCC1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 ALLGYQCYCLBXGQ-MZNJEOGPSA-N 0.000 description 1
- KHAUXAKKVSWVTD-IQGLISFBSA-N N#CCCC1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 Chemical compound N#CCCC1=CC=C(OC2=C3CC[C@@H](OC4=CC=C5C(=C4)OC[C@H]5CC(=O)O)C3=C(F)C=C2)C=C1 KHAUXAKKVSWVTD-IQGLISFBSA-N 0.000 description 1
- YSOQYINWYPZZQW-FWJOYPJLSA-N O=C(O)C[C@@H]1COC2=CC(OC3CCC4=C3C=CC=C4)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(OC3CCC4=C3C=CC=C4)=CC=C21 YSOQYINWYPZZQW-FWJOYPJLSA-N 0.000 description 1
- JIEVMZUTKXYSRI-DNOBIOAJSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(F)=C(OCC6(O)CCOCC6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(F)=C(OCC6(O)CCOCC6)C=C5)C=CC(F)=C43)=CC=C21 JIEVMZUTKXYSRI-DNOBIOAJSA-N 0.000 description 1
- NARZRZMLYOWWPG-LNZPYGSCSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(O[C@H]6CCOC6)=NC=C5)C=CC(F)=C43)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC(O[C@H]6CCOC6)=NC=C5)C=CC(F)=C43)=CC=C21 NARZRZMLYOWWPG-LNZPYGSCSA-N 0.000 description 1
- ZJPHUFHQSLWGAL-VOIUYBSRSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC6=C(C=C5)CCC(=O)N6)C=CC(F)=C43)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC6=C(C=C5)CCC(=O)N6)C=CC(F)=C43)=CC=C21 ZJPHUFHQSLWGAL-VOIUYBSRSA-N 0.000 description 1
- QUPLKAZVIIXSHL-VOIUYBSRSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC6=C(C=C5)OCC6)C=CC(F)=C43)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC6=C(C=C5)OCC6)C=CC(F)=C43)=CC=C21 QUPLKAZVIIXSHL-VOIUYBSRSA-N 0.000 description 1
- SVBWIGITYPKBMB-NIYFSFCBSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C(=O)N6CCOCC6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C(=O)N6CCOCC6)C=C5)C=CC(F)=C43)=CC=C21 SVBWIGITYPKBMB-NIYFSFCBSA-N 0.000 description 1
- SSBWAJCUKIXTPZ-VOIUYBSRSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NN=NC6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(C6=NN=NC6)C=C5)C=CC(F)=C43)=CC=C21 SSBWAJCUKIXTPZ-VOIUYBSRSA-N 0.000 description 1
- UMQPWNWMMXEYGW-NFQMXDRXSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(CN6CCOCC6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(CN6CCOCC6)C=C5)C=CC(F)=C43)=CC=C21 UMQPWNWMMXEYGW-NFQMXDRXSA-N 0.000 description 1
- KPOJHGKQLMOGCO-CRICUBBOSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(N6C=CN=C6)C=C5)C=CC(F)=C43)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(N6C=CN=C6)C=C5)C=CC(F)=C43)=CC=C21 KPOJHGKQLMOGCO-CRICUBBOSA-N 0.000 description 1
- LKCILCBWMUAFPR-CRICUBBOSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(N6CCCC6=O)C=C5)C=CC(F)=C=43)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(N6CCCC6=O)C=C5)C=CC(F)=C=43)=CC=C21 LKCILCBWMUAFPR-CRICUBBOSA-N 0.000 description 1
- BBHYNRGWMWLGMN-XGCWNURASA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(OC6CCOCC6)C=C5F)C=CC(F)=C43)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=C(OC6CCOCC6)C=C5F)C=CC(F)=C43)=CC=C21 BBHYNRGWMWLGMN-XGCWNURASA-N 0.000 description 1
- ZXBMKYBHYVBXAU-CRICUBBOSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=CC(N6CCCC6=O)=C5)C=CC(F)=C43)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C(OC5=CC=CC(N6CCCC6=O)=C5)C=CC(F)=C43)=CC=C21 ZXBMKYBHYVBXAU-CRICUBBOSA-N 0.000 description 1
- ALGGUQCHXGQSKK-JLCFBVMHSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C/C4=C(\C=C/3)OCO4)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=C/C4=C(\C=C/3)OCO4)=CC=C21 ALGGUQCHXGQSKK-JLCFBVMHSA-N 0.000 description 1
- GNKIERIJKJGUNZ-IQMFZBJNSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC4=C(C=C3)OCCO4)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC4=C(C=C3)OCCO4)=CC=C21 GNKIERIJKJGUNZ-IQMFZBJNSA-N 0.000 description 1
- SKTUPYGXKIGFAQ-NFQMXDRXSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(C4CCOCC4)C=C3)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(C4CCOCC4)C=C3)=CC=C21 SKTUPYGXKIGFAQ-NFQMXDRXSA-N 0.000 description 1
- OYFYXYRLSYNTHN-LYZGTLIUSA-N O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(CC4CCOCC4)C=C3)=CC=C21 Chemical compound O=C(O)C[C@@H]1COC2=CC(O[C@@H]3CCC4=C3C(F)=CC=C4OC3=CC=C(CC4CCOCC4)C=C3)=CC=C21 OYFYXYRLSYNTHN-LYZGTLIUSA-N 0.000 description 1
- NLVVNRITLSLCDP-QMMMGPOBSA-N O[C@H]1CCC2=C1C(F)=CC=C2Br Chemical compound O[C@H]1CCC2=C1C(F)=CC=C2Br NLVVNRITLSLCDP-QMMMGPOBSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Definitions
- the present invention relates to novel indanyloxydihydrobenzofuranylacetic acids, that are agonists of the G-protein coupled receptor 40 (GPR40, also known as free fatty acid receptor FFAR 1), to processes for their preparation, to pharmaceutical compositions containing these compounds and to their medical use for the prophylaxis and/or treatment of diseases which can be influenced by the modulation of the function of GPR40.
- GPR40 G-protein coupled receptor 40
- FFAR1 free fatty acid receptor 1
- the pharmaceutical compositions of the invention are suitable for the prophylaxis and/or therapy of metabolic diseases, such as diabetes, more specifically type 2 diabetes mellitus, and conditions associated with the disease, including insulin resistance, obesity, cardiovascular disease and dyslipidemia.
- Metabolic diseases are diseases caused by an abnormal metabolic process and may either be congenital due to an inherited enzyme abnormality or acquired due to a disease of an endocrine organ or failure of a metabolically important organ such as the liver or the pancreas.
- Diabetes mellitus is a disease state or process derived from multiple causative factors and is defined as a chronic hyperglycemia associated with resulting damages to organs and dysfunctions of metabolic processes. Depending on its etiology, one differentiates between several forms of diabetes, which are either due to an absolute (lacking or decreased insulin secretion) or to a relative lack of insulin. Diabetes mellitus Type I (IDDM, insulin-dependent diabetes mellitus) generally occurs in adolescents under 20 years of age. It is assumed to be of auto-immune etiology, leading to an insulitis with the subsequent destruction of the beta cells of the islets of Langerhans which are responsible for the insulin synthesis. In addition, in latent autoimmune diabetes in adults (LADA; Diabetes Care.
- LADA latent autoimmune diabetes in adults
- beta cells are being destroyed due to autoimmune attack.
- the amount of insulin produced by the remaining pancreatic islet cells is too low, resulting in elevated blood glucose levels (hyperglycemia).
- Diabetes mellitus Type II generally occurs at an older age. It is above all associated with a resistance to insulin in the liver and the skeletal muscles, but also with a defect of the islets of Langerhans. High blood glucose levels (and also high blood lipid levels) in turn lead to an impairment of beta cell function and to an increase in beta cell apoptosis.
- Persistent or inadequately controlled hyperglycemia is associated with a wide range of pathologies. Diabetes is a very disabling disease, because today's common anti-diabetic drugs do not control blood sugar levels well enough to completely prevent the occurrence of high and low blood sugar levels. Out of range blood sugar levels are toxic and cause long-term complications for example retinopathy, renopathy, neuropathy and peripheral vascular disease. There is also a host of related conditions, such as obesity, hypertension, stroke, heart disease and hyperlipidemia, for which persons with diabetes are substantially at risk.
- Obesity is associated with an increased risk of follow-up diseases such as cardiovascular diseases, hypertension, diabetes, hyperlipidemia and an increased mortality.
- Diabetes (insulin resistance) and obesity are part of the “metabolic syndrome” which is defined as the linkage between several diseases (also referred to as syndrome X, insulin-resistance syndrome, or deadly quartet). These often occur in the same patients and are major risk factors for development of diabetes type II and cardiovascular disease. It has been suggested that the control of lipid levels and glucose levels is required to treat diabetes type II, heart disease, and other occurrences of metabolic syndrome (see e.g., Diabetes 48: 1836-1841, 1999; JAMA 288: 2209-2716, 2002).
- the free fatty acid receptor GPR40 (also referred to as either FFAR, FFAR1, or FFA1) is a cell-surface receptor and a member of the gene superfamily of G-protein coupled receptors, which was first identified as a so-called orphan receptor, i.e. a receptor without a known ligand, based on the predicted prescence of seven putative transmembrane regions in the corresponding protein (Sawzdargo et al. (1997) Biochem. Biophys. Res. Commun. 239: 543-547).
- GPR40 is found to be highly expressed in several particular cell types: the pancreatic ⁇ cells and insulin-secreting cell lines, as well as in enteroendocrine cells, taste cells, and is reported to be expressed in immune cells, splenocytes, and in the human and monkey brain. Meanwhile, fatty acids of varying chain lengths are thought to represent the endogenous ligands for GPR40, activation of which is linked primarily to the modulation of the Gq family of intra-cellular signaling G proteins and concomitant induction of elevated calcium levels, although activation of Gs- and G1-proteins to modulate intracellular levels of cAMP have also been reported. GPR40 is activated especially by long-chain FFA, particularly oleate, as well as the PPAR-gamma agonist rosiglitazone.
- GPR40 agonists may have the potential to restore or preserve islet function, therefore, GPR40 agonists may be beneficial also in that that they may delay or prevent the diminution and loss of islet function in a Type 2 diabetic patient.
- GLP-1 glucagon-like peptide-1
- GIP glycose-dependent insulinotropic peptide; also known as gastric inhibitory peptide
- endocrine cells that are located in the epithelium of the small intestine. When these endocrine cells sense an increase in the concentration of glucose in the lumen of the digestive tract, they act as the trigger for incretin release. Incretins are carried through the circulation to beta cells in the pancreas and cause the beta cells to secrete more insulin in anticipation of an increase of blood glucose resulting from the digesting meal.
- GPR40 modulators may contribute to enhanced insulin release from the pancreatic beta cells also indirectly by e.g. a synergistic effect of GLP-1 and possibly GIP on the insulin release, and the other release incretins may also contribute to an overall beneficial contribution of GPR40 modulation on metabolic diseases.
- the indirect contributions of GPR40 modulation on insulin release through the elevation of plasma levels of incretins may be further augmented by the coadministration of inhibitors of the enzymes responsible for the incretin degradation, such as inhibitors of DPP-4.
- GPR40 in modulating insulin secretion indicates the therapeutic agents capable of modulating GPR40 function could be useful for the treatment of disorders such as diabetes and conditions associated with the disease, including insulin resistance, obesity, cardiovascular disease and dyslipidemia.
- the object of the present invention is to provide new compounds, hereinafter described as compounds of formula I, in particular new indanyloxy-2,3-dihydrobenzofuranylacetic acids, which are active with regard to the G-protein-coupled receptor GPR40, notably are agonists of the G-protein-coupled receptor GPR40.
- a further object of the present invention is to provide new compounds, in particular new indanyloxydihydrobenzofuranylacetic acids, which have an activating effect on the G-protein-coupled receptor GPR40 in vitro and/or in vivo and possess suitable pharmacological and pharmacokinetic properties to use them as medicaments.
- a further object of the present invention is to provide effective GPR40 agonists, in particular for the treatment of metabolic disorders, for example diabetes, dyslipidemia and/or obesity.
- a further object of the present invention is to provide methods for treating a disease or condition mediated by the activation the G-protein-coupled receptor GPR40 in a patient.
- a further object of the present invention is to provide a pharmaceutical composition comprising at least one compound according to the invention.
- a further object of the present invention is to provide a combination of at least one compound according to the invention with one or more additional therapeutic agents.
- GPR40 modulators are known in the art, for example, the compounds disclosed in WO 2004041266 (EP 1559422), WO 2007033002, WO 2009157418 and WO 2012072691.
- the indanyloxydihydrobenzofuranylacetic acids of the present invention may provide several advantages, such as enhanced potency, high metabolic and/or chemical stability, high selectivity and tolerability, enhanced solubility, and the possibility to form stable salts.
- F atoms optionally substituted with 1 or more F atoms.
- F atoms preferably 1 to 5 H atoms or, more preferred, 1 to 3 H atoms may be replaced by F atoms.
- extension -Gn used within the definitions is meant to identify genus n of the respective substituent.
- R 1 -G1 defines genus 1 of the substituent R 1 .
- this invention relates to a pharmaceutical composition, comprising one or more compounds of general formula I or one or more pharmaceutically acceptable salts thereof according to the invention, optionally together with one or more inert carriers and/or diluents.
- this invention relates to a method for treating diseases or conditions which are mediated by activating the G-protein-coupled receptor GPR40 in a patient in need thereof characterized in that a compound of general formula I or a pharmaceutically acceptable salt thereof is administered to the patient.
- a method for treating a metabolic disease or disorder such as diabetes, dyslipidemia and/or obesity, in a patient in need thereof characterized in that a therapeutically effective amount of a compound of general formula I or a pharmaceutically acceptable salt thereof is administered to the patient.
- this invention relates to a method for treating a disease or condition mediated by the activation of the G-protein-coupled receptor GPR40 in a patient that includes the step of administering to the patient in need of such treatment a therapeutically effective amount of a compound of the general formula I or a pharmaceutically acceptable salt thereof in combination with a therapeutically effective amount of one or more additional therapeutic agents.
- this invention relates to the use of a compound of the general formula I or a pharmaceutically acceptable salt thereof in combination with one or more additional therapeutic agents for the treatment of diseases or conditions which are mediated by the activation of the G-protein-coupled receptor GPR40.
- this invention relates to a pharmaceutical composition which comprises a compound according to general formula I or a pharmaceutically acceptable salt thereof and one or more additional therapeutic agents, optionally together with one or more inert carriers and/or diluents.
- the group (Het)Ar is preferably selected from the group (Het)Ar-G1 as defined hereinbefore.
- the group (Het)Ar is selected from the group (Het)Ar-G2 consisting of phenyl, naphthyl, and a heteroaromatic group linked via a carbon atom having 5 to 10 ring member atoms of which 2 to 9 atoms are carbon atoms and either
- the group (Het)Ar is selected from the group (Het)Ar-G3 consisting of
- the group (Het)Ar is selected from the group (Het)Ar-G4 consisting of
- group (Het)Ar is selected from the group (Het)Ar-G5 consisting of
- each of these groups is substituted with one group R 2 and optionally substituted with 1 to 3 groups independently selected from R 3 .
- group (Het)Ar is selected from the group (Het)Ar-G5a consisting of
- group (Het)Ar is selected from the group (Het)Ar-G5b consisting of
- each of these groups is substituted with one group R 2 and optionally substituted with 1 or 2 groups independently selected from R 3 .
- group (Het)Ar is selected from the group (Het)Ar-G5c consisting of
- each of these groups is substituted with one group R 2 and optionally substituted with 1 to 3 groups independently selected from R 3 .
- group (Het)Ar is selected from the group (Het)Ar-G6 consisting of
- each of the phenyl subgroups is optionally additionally substituted with 1 or 2 F atoms or 1 CN group.
- group (Het)Ar is selected from the group (Het)Ar-G6a consisting of
- the group R 1 is preferably selected from the group R 1 -G1 as defined hereinbefore.
- the group R 1 is selected from the group R 1 -G2 consisting of H, F, Cl, F 3 C— and NC—.
- the group R 1 is H.
- the group R 2 is preferably selected from the group R 2 -G1 as defined hereinbefore.
- the group R 2 is selected from the group R 2 -G2 consisting of C 1-4 -alkyl, C 3-6 -cycloalkyl-, C 1-4 -alkyl-O—, C 3-6 -cycloalkyl-O—, C 1-4 -alkyl-S( ⁇ O)—, and C 1-4 -alkyl-S( ⁇ O) 2 —,
- the group R 2 is selected from the group R 2 -G3 consisting of C 1-4 -alkyl, C 3-6 -cycloalkyl-, C 1-4 -alkyl-O— and C 3-6 -cycloalkyl-O—,
- the group R 2 is selected from the group R 2 -G4 consisting of C 1-4 -alkyl, C 3-6 -cycloalkyl-, C 1-4 -alkyl-O— and C 3-6 -cycloalkyl-O—,
- the group R 2 is selected from the group R 2 -G5 consisting of
- the group R 2 is selected from the group R 2 -G6 consisting of
- the group R 2 is selected from the group R 2 -G6a consisting of
- the group R 3 is preferably selected from the group R 3 -G1 as defined hereinbefore.
- the group R 3 is selected from the group R 3 -G2 consisting of F, Cl, CN, C 1-3 -alkyl, C 3-4 -cycloalkyl-, C 1-3 -alkyl-O— and H 3 C—S( ⁇ O) 2 —, wherein any alkyl and cycloalkyl group is optionally substituted with 1 or more F atoms.
- the group R 3 is selected from the group R 3 -G3 consisting of F, —CH 3 and CN.
- the group R 3 is F.
- the group R 4 is preferably selected from the group R 4 -G1 as defined hereinbefore.
- the group R 4 is selected from the group R 4 -G2 consisting of C 1-4 -alkyl-, —CN, C 3-6 -cycloalkyl-, heterocyclyl-C( ⁇ O)—, H 2 N—C( ⁇ O)—, C 1-4 -alkyl-NR N —C( ⁇ O)—, C 3-6 -cycloalkyl-NR N —C( ⁇ O)—, heterocyclyl-NR N —C( ⁇ O)—, heteroaryl-NR N —C( ⁇ O)—, —NH 2 , C 1-4 -alkyl-NR N —, C 1-4 -alkyl-C( ⁇ O)NR N —, C 3-6 -cycloalkyl-C( ⁇ O)NR N —, heterocyclyl-C( ⁇ O)NR N —, heteroaryl-C( ⁇ O)NR N —, C 1-4 -alkyl-S( ⁇ O) 2 NR N —, ——
- the group R 4 is selected from the group R 4 -G3 consisting of C 1-4 -alkyl-, —CN, C 3-6 -cycloalkyl-, heterocyclyl-C( ⁇ O)—, H 2 N—C( ⁇ O)—, —C( ⁇ O)NHCH 3 , —C( ⁇ O)N(CH 3 ) 2 , —N(CH 3 ) 2 , C 1-3 -alkyl-C( ⁇ O)NR N —, C 1-3 -alkyl-S( ⁇ O) 2 NR N —, —OH, C 1-4 -alkyl-O—, C 3-6 -cycloalkyl-O—, heterocyclyl-O—, C 1-3 -alkyl-S( ⁇ O)—, C 1-3 -alkyl-S( ⁇ O) 2 —, heterocyclyl and heteroaryl,
- the group R 4 is selected from the group R 4 -G4 consisting of C 1-2 -alkyl-, —CN, H 2 N—C( ⁇ O)—, —C( ⁇ O)NHCH 3 , —C( ⁇ O)N(CH 3 ) 2 , —N(CH 3 ) 2 , H 3 C—C( ⁇ O)NH—, H 3 C—S( ⁇ O) 2 NH—, —OH, C 1-3 -alkyl-O—, heterocyclyl-O—, H 3 C—S( ⁇ O)—, H 3 C—S( ⁇ O) 2 —, heterocyclyl, and heteroaryl,
- the group R 4 is selected from the group R 4 -G5 consisting of
- the group R 4 is selected from the group R 4 -G5a consisting of
- group R 4 is selected from the group R 4 -G6 consisting of
- the group R 5 is preferably selected from the group R 5 -G1 as defined hereinbefore.
- the group R 5 is selected from the group R 5 -G2 consisting of F, Cl, C 1-3 -alkyl, HO—C 1-4 -alkyl-, —CF 3 , —CN, C 1-3 -alkyl-O—, F 3 C—O—, —S( ⁇ O)CH 3 and —S( ⁇ O) 2 —CH 3 .
- the group R 5 is selected from the group R 5 -G3 consisting of F, —CH 3 , HO—C(CH 3 ) 2 —CH 2 —, —CF 3 , —CN and —OCH 3 .
- the group R 5 is selected from the group R 5 -G4 consisting of —CH 3 and HO—C(CH 3 ) 2 —CH 2 —.
- the group R N is preferably selected from the group R N -G1 as defined hereinbefore.
- the group R N is selected from the group R N -G2 consisting of H, C 1-3 -alkyl, H 3 C—C( ⁇ O)—, and C 1-3 -alkyl-S( ⁇ O) 2 —.
- the group R N is selected from the group R N -G3 consisting of H, H 3 C—, H 3 C—C( ⁇ O)—, and C 1-3 -alkyl-S( ⁇ O) 2 —.
- the compounds according to the invention and their intermediates may be obtained using methods of synthesis which are known to the one skilled in the art and described in the literature of organic synthesis. Preferably the compounds are obtained analogously to the methods of preparation explained more fully hereinafter, in particular as described in the experimental section. In some cases the sequence adopted in carrying out the reaction schemes may be varied. Variants of these reactions that are known to the skilled man but are not described in detail here may also be used.
- the general processes for preparing the compounds according to the invention will become apparent to the skilled man on studying the schemes that follow. Starting compounds are commercially available or may be prepared by methods that are described in the literature or herein, or may be prepared in an analogous or similar manner. Before the reaction is carried out any corresponding functional groups in the compounds may be protected using conventional protecting groups. These protecting groups may be cleaved again at a suitable stage within the reaction sequence using methods familiar to the skilled man.
- the compounds of the invention I are preferably accessed from a precursor 1 that bears the carboxylic acid protected as ester (Scheme 1); (Het)Ar and R 1 have the meanings as defined hereinbefore and hereinafter.
- the ester group may be hydrolysed in the presence of an acid, such as hydrochloric acid or sulfuric acid, or an alkali metal hydroxide, such as lithium hydroxide, sodium hydroxide, or potassium hydroxide, to yield the carboxylic acid.
- the hydrolysis is preferably conducted in aqueous solvents, such as water combined with tetrahydrofuran, 1,4-dioxane, alcohol, e.g.
- a tert-butyl ester is preferably cleaved under acidic conditions, e.g. trifluoroacetic acid or hydrochloric acid, in a solvent, such as dichloromethane, 1,4-dioxane, isopropanol or ethyl acetate.
- a benzyl ester is advantageously cleaved using hydrogen in the presence of a transition metal, preferably palladium on carbon.
- Benzyl esters bearing electron donating groups on the phenyl ring, such as methoxy, may also be removed under oxidative conditions; ceric ammonium nitrate (CAN) or 2,3-dichloro-5,6-dicyanoquinone (DDQ) are reagents commonly used for this
- Compound I may be assembled using building blocks 2, 3 and 4 (Scheme 2); (Het)Ar and R 1 have the meanings as defined hereinbefore and hereinafter.
- Phosphines often used are triphenylphosphine and tributylphosphine, which are commonly combined with dimethyl azodicarboxylate, diethyl azodicarboxylate, diisopropyl azodicarboxylate, di-(4-chlorobenzyl) azodicarboxylate, dibenzyl azodicarboxylate, di-tert-butyl azodicarboxylate, azodicarboxylic acid bis-(dimethylamide), azodicarboxylic acid dipiperidide, or azodicarboxylic acid dimorpholide.
- the group (Het)Ar may be attached to the indane moiety via an oxygen starting from various precursors (Scheme 4); (Het)Ar and R 1 have the meanings as defined hereinbefore and hereinafter.
- the two parts may be linked using one of them decorated with a hydroxy group (X or Z denotes OH) and the other one with a boronic acid group (X or Z denotes B(OH) 2 ).
- the two building blocks accordingly equipped may be coupled employing copper(II) acetate in the presence of a base, e.g. pyridine or triethylamine, molecular sieves, optionally a co-oxidant, e.g. oxygen, in a solvent, e.g.
- Cs 2 CO 3 , K 2 CO 3 , KOH, triethylamine or NaH preferably in a solvent, e.g. toluene, tetrahydrofuran, 1,2-dimethoxyethane, 1,4-dioxane, N,N-dimethylformamide, N,N-dimethylacetamide, N-methylpyrrolidinone, alcohol, water or mixtures thereof, at 0 to 220° C.
- the transition metal catalyzed coupling is used for (Het)Ar groups bearing Cl, Br or I as leaving group.
- Suitable transition metal catalysts are commonly derived from palladium or copper.
- the active catalyst may be an elemental form of the transition metal or formed from a salt of the transition metal, such as fluoride, chloride, bromide, iodide, acetate, triflate or trifluoroacetate, which are optionally combined with ligands, such as phosphines, e.g.
- tri-tert-butylphosphine tricyclohexylphosphine, optionally substituted biphenyl-dicyclohexyl-phosphines, optionally substituted biphenyl-di-tert-butyl-phosphines, 1,1′-bis(diphenylphosphino)-ferrocene, triphenylphosphine, tritolylphosphine, or trifurylphosphine, phosphites, 1,3-disubstituted imidazole carbenes, 1,3-disubstituted imidazolidine carbenes, pyridines or phenanthrolines.
- the reaction is usually carried out in the presence of a base, e.g. NaOH, KOH, Na 2 CO 3 , K 2 CO 3 , Cs 2 CO 3 , triethylamine or ethyldiisopropylamine, in toluene, tetrahydrofuran, 1,2-dimethoxyethane, 1,4-dioxane, N,N-dimethylformamide, N,N-dimethylacetamide, N-methylpyrrolidinone, alcohol, water, or mixtures thereof, preferably at 10 to 180° C.
- a base e.g. NaOH, KOH, Na 2 CO 3 , K 2 CO 3 , Cs 2 CO 3 , triethylamine or ethyldiisopropylamine, in toluene, tetrahydrofuran, 1,2-dimethoxyethane, 1,4-dioxane, N,N-dimethylformamide, N,N
- Intermediate 3 or derivatives thereof, as 3′′, may be obtained from indanone 7, which, in turn, may be prepared from phenylpropionic acid derivative 6 (Scheme 5); R 1 has the meaning as defined hereinbefore and hereinafter.
- R 1 has the meaning as defined hereinbefore and hereinafter.
- 6 ⁇ 7 a considerable number of approaches has been reported.
- the reaction may be performed starting with a carboxylic acid, carboxylic ester, carboxylic anhydride, carboxylic chloride or fluoride, or a nitrile using a Lewis acid as catalyst.
- Lewis acids are some of the more often used ones: hydrobromic acid, hydroiodic acid, hydrochloric acid, sulfuric acid, phosphoric acid, P 4 O 10 , trifluoroacetic acid, methanesulfonic acid, toluenesulfonic acid, trifluoromethanesulfonic acid, ClSO 3 H, Sc(OSO 2 CF 3 ) 3 , Tb(OSO 2 CF 3 ) 3 , SnCl 4 , FeCl 3 , AlBr 3 , AlCl 3 , SbCl 5 , BCl 3 , BF 3 , ZnCl 2 , montmorillonites, POCl 3 , and PCl 5 .
- the reaction may be conducted, e.g., in dichloromethane, 1,2-dichloroethane, nitrobenzene, chlorobenzene, carbon disulfide, mixtures thereof, or without an additional solvent in an excess of the Lewis acid, at 0 to 180° C.
- Carboxylic acids are preferably reacted in polyphosphoric acid at 0 to 120° C.
- carboxylic chlorides are preferably reacted with AlCl 3 in dichloromethane or 1,2-dichloroethane at 0 to 80° C.
- the subsequent reduction of the keto group in compound 7 providing the alcohol 3′′ in enantiomerically enriched or pure form may be accomplished using hydrogen or a hydrogen source, such as formate or silane, and a transition metal catalyst derived from, e.g., Ir, Rh, Ru or Fe and a chiral auxiliary.
- a hydrogen source such as formate or silane
- a transition metal catalyst derived from, e.g., Ir, Rh, Ru or Fe and a chiral auxiliary.
- a ruthenium complex such as chloro ⁇ [(1S,2S)-( ⁇ )-2-amino-1,2-diphenylethyl](4-toluenesulfonyl)-amido ⁇ -(mesitylene)ruthenium(II)
- a ruthenium complex may deliver the hydroxy compound 3′′ with high enantiomeric excess using, e.g., formic acid in the presence of a base, e.g. triethylamine, in dichloromethane, at ⁇ 20 to 60° C.
- boranes combined with an enantiomerically pure [1,3,2]oxazaborol may be used as reducing agent (Corey-Bakshi-Shibata reaction or Corey-Itsuno reaction).
- Typical reaction conditions for this approach are borane (complexed with, e.g., dimethyl sulfide) and (R)- or (S)-3,3-diphenyl-1-methyltetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborol in, e.g., dichloromethane, toluene, methanol, tetrahydrofuran, or mixtures thereof, at 0 to 60° C.
- protecting groups For example, potentially reactive groups present, such as hydroxy, carbonyl, carboxy, amino, alkylamino, or imino, may be protected during the reaction by conventional protecting groups which are cleaved again after the reaction. Suitable protecting groups for the respective functionalities and their removal are well known to the one skilled in the art and are described in the literature of organic synthesis.
- the compounds of general formula I may be resolved into their enantiomers and/or diastereomers as mentioned below.
- cis/trans mixtures may be resolved into their cis and trans isomers and racemic compounds may be separated into their enantiomers.
- the cis/trans mixtures may be resolved, for example, by chromatography into the cis and trans isomers thereof.
- the compounds of general formula I which occur as racemates may be separated by methods known per se into their optical antipodes and diastereomeric mixtures of compounds of general formula I may be resolved into their diastereomers by taking advantage of their different physico-chemical properties using methods known per se, e.g. chromatography and/or fractional crystallization; if the compounds obtained thereafter are racemates, they may be resolved into the enantiomers as mentioned below.
- racemates are preferably resolved by column chromatography on chiral phases or by crystallization from an optically active solvent or by reacting with an optically active substance which forms salts or derivatives such as esters or amides with the racemic compound.
- Salts may be formed with enantiomerically pure acids for basic compounds and with enantiomerically pure bases for acidic compounds.
- Diastereomeric derivatives are formed with enantiomerically pure auxiliary compounds, e.g. acids, their activated derivatives, or alcohols. Separation of the diastereomeric mixture of salts or derivatives thus obtained may be achieved by taking advantage of their different physico-chemical properties, e.g.
- the free antipodes may be released from the pure diastereomeric salts or derivatives by the action of suitable agents.
- Optically active acids commonly used for such a purpose as well as optically active alcohols applicable as auxiliary residues are known to those skilled in the art.
- the compounds of formula I may be converted into salts, particularly for pharmaceutical use into the pharmaceutically acceptable salts.
- pharmaceutically acceptable salts refer to derivatives of the disclosed compounds wherein the parent compound is modified by making acid or base salts thereof.
- compound(s) according to this invention denote the compounds of the formula (I) according to the present invention including their tautomers, stereoisomers and mixtures thereof and the salts thereof, in particular the pharmaceutically acceptable salts thereof, and the solvates and hydrates of such compounds, including the solvates and hydrates of such tautomers, stereoisomers and salts thereof.
- treatment embrace both preventative, i.e. prophylactic, or therapeutic, i.e. curative and/or palliative, treatment.
- treatment and “treating” comprise therapeutic treatment of patients having already developed said condition, in particular in manifest form.
- Therapeutic treatment may be symptomatic treatment in order to relieve the symptoms of the specific indication or causal treatment in order to reverse or partially reverse the conditions of the indication or to stop or slow down progression of the disease.
- compositions and methods of the present invention may be used for instance as therapeutic treatment over a period of time as well as for chronic therapy.
- treatment and “treating” comprise prophylactic treatment, i.e. a treatment of patients at risk to develop a condition mentioned hereinbefore, thus reducing said risk.
- this invention refers to patients requiring treatment, it relates primarily to treatment in mammals, in particular humans.
- terapéuticaally effective amount means an amount of a compound of the present invention that (i) treats or prevents the particular disease or condition, (ii) attenuates, ameliorates, or eliminates one or more symptoms of the particular disease or condition, or (iii) prevents or delays the onset of one or more symptoms of the particular disease or condition described herein.
- modulated or “modulating”, or “modulate(s)”, as used herein, unless otherwise indicated, refer to the activation of the G-protein-coupled receptor GPR40 with one or more compounds of the present invention.
- mediated refers to the (i) treatment, including prevention of the particular disease or condition, (ii) attenuation, amelioration, or elimination of one or more symptoms of the particular disease or condition, or (iii) prevention or delay of the onset of one or more symptoms of the particular disease or condition described herein.
- substituted means that any one or more hydrogens on the designated atom, radical or moiety is replaced with a selection from the indicated group, provided that the atom's normal valence is not exceeded, and that the substitution results in an acceptably stable compound.
- C 1-6 -alkyl means an alkyl group or radical having 1 to 6 carbon atoms.
- the last named subgroup is the radical attachment point, for example, the substituent “aryl-C 1-3 -alkyl-” means an aryl group which is bound to a C 1-3 -alkyl-group, the latter of which is bound to the core or to the group to which the substituent is attached.
- An asterisk may be used in sub-formulas to indicate the bond which is connected to the core molecule as defined.
- the numeration of the atoms of a substituent starts with the atom which is closest to the core or to the group to which the substituent is attached.
- 3-carboxypropyl-group represents the following substituent:
- the asterisk may be used in sub-formulas to indicate the bond which is connected to the core molecule as defined.
- each X, Y and Z group is optionally substituted with
- each group X, each group Y and each group Z either each as a separate group or each as part of a composed group may be substituted as defined.
- R ex denotes H, C 1-3 -alkyl, C 3-6 -cycloalkyl, C 3-6 -cycloalkyl-C 1-3 -alkyl or C 1-3 -alkyl-O—, wherein each alkyl group is optionally substituted with one or more L ex .” or the like means that in each of the beforementioned groups which comprise the term alkyl, i.e. in each of the groups C 1-3 -alkyl, C 3-6 -cycloalkyl-C 1-3 -alkyl and C 1-3 -alkyl-O—, the alkyl moiety may be substituted with L ex as defined.
- a given chemical formula or name shall encompass tautomers and all stereo, optical and geometrical isomers (e.g. enantiomers, diastereomers, E/Z isomers etc. . . . ) and racemates thereof as well as mixtures in different proportions of the separate enantiomers, mixtures of diastereomers, or mixtures of any of the foregoing forms where such isomers and enantiomers exist, as well as salts, including pharmaceutically acceptable salts thereof and solvates thereof such as for instance hydrates including solvates of the free compounds or solvates of a salt of the compound.
- phrases “pharmaceutically acceptable” is employed herein to refer to those compounds, materials, compositions, and/or dosage forms which are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problem or complication, and commensurate with a reasonable benefit/risk ratio.
- pharmaceutically acceptable salts refer to derivatives of the disclosed compounds wherein the parent compound is modified by making acid or base salts thereof.
- Salts of other acids than those mentioned above which for example are useful for purifying or isolating the compounds of the present invention e.g. trifluoro acetate salts
- Salts of other acids than those mentioned above which for example are useful for purifying or isolating the compounds of the present invention also comprise a part of the invention.
- halogen generally denotes fluorine, chlorine, bromine and iodine.
- C 1-5 -alkyl embraces the radicals H 3 C—, H 3 C—CH 2 —, H 3 C—CH 2 —CH 2 —, H 3 C—CH(CH 3 )—, H 3 C—CH 2 —CH 2 —CH 2 —, H 3 C—CH 2 —CH(CH 3 )—, H 3 C—CH(CH 3 )—CH 2 —, H 3 C—C(CH 3 ) 2 —, H 3 C—CH 2 —CH 2 —CH 2 —CH 2 —, H 3 C—CH 2 —CH 2 —CH(CH 3 )—, H 3 C—CH 2 —CH(CH 3 )—CH 2 —, H 3 C—CH(CH 3 )—CH 2 —, H 3 C—CH(CH 3 )—CH 2 —, H 3 C—CH(CH 3 )—CH 2 —, H 3 C—CH(CH 3 )—CH 2 —, H 3 C—CH(CH 3 )—CH 2
- C 1-n -alkylene wherein n is an integer 1 to n, either alone or in combination with another radical, denotes an acyclic, straight or branched chain divalent alkyl radical containing from 1 to n carbon atoms.
- C 1-4 -alkylene includes —(CH 2 )—, —(CH 2 —CH 2 )—, —(CH(CH 3 ))—, —(CH 2 —CH 2 —CH 2 )—, —(C(CH 3 ) 2 )—, —(CH(CH 2 CH 3 ))—, —(CH(CH 3 )—CH 2 )—, —(CH 2 —CH(CH 3 ))—, —(CH 2 —CH 2 —CH 2 —CH 2 )—, —(CH 2 —CH 2 —CH(CH 3 ))—, —(CH(CH 3 )—CH 2 —CH 2 )—, —(CH 2 —CH(CH 3 )—CH 2 —CH 2 )—, —(CH 2 —CH(CH 3 )—CH 2 )—, —(CH 2 —CH(CH 3 )—CH 2 )—, —(CH 2 —CH(
- C 2-n -alkenyl is used for a group as defined in the definition for “C 1-n -alkyl” with at least two carbon atoms, if at least two of those carbon atoms of said group are bonded to each other by a double bond.
- C 2-3 -alkenyl includes —CH ⁇ CH 2 , —CH ⁇ CH—CH 3 , —CH 2 —CH ⁇ CH 2 .
- C 2-n -alkynyl is used for a group as defined in the definition for “C 1-n -alkyl” with at least two carbon atoms, if at least two of those carbon atoms of said group are bonded to each other by a triple bond.
- C 2-3 -alkynyl includes —C ⁇ CH, —C ⁇ C ⁇ CH 3 , —CH 2 —C ⁇ CH.
- C 3-n -carbocyclyl denotes a monocyclic, bicyclic or tricyclic, saturated or unsaturated hydrocarbon radical with 3 to n C atoms.
- the hydrocarbon radical is preferably nonaromatic.
- the 3 to n C atoms form one or two rings.
- the rings may be attached to each other via a single bond or may be fused or may form a spirocyclic or bridged ring system.
- C 3-10 -carbocyclyl includes C 3-10 -cylcoalkyl, C 3-10 -cycloalkenyl, octahydropentalenyl, octahydroindenyl, decahydronaphthyl, indanyl, tetrahydronaphthyl.
- C 3-n -carbocyclyl denotes C 3-n -cylcoalkyl, in particular C 3-7 -cycloalkyl.
- C 3-n -cycloalkyl wherein n is an integer 4 to n, either alone or in combination with another radical denotes a cyclic, saturated, unbranched hydrocarbon radical with 3 to n C atoms.
- the cyclic group may be mono-, bi-, tri- or spirocyclic, most preferably monocyclic.
- cycloalkyl groups include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, cyclododecyl, bicyclo[3.2.1.]octyl, spiro[4.5]decyl, norpinyl, norbonyl, norcaryl, adamantyl, etc.
- heteroaryl is intended to include all the possible isomeric forms.
- heteroaryl or heteroaromatic group includes the following exemplary structures which are not depicted as radicals as each form may be attached through a covalent bond to any atom so long as appropriate valences are maintained:
- Degradation kinetics is used to simulate chemical stability of compounds in the acidic part of the gastro intestinal tract.
- the compounds of the invention show significantly superior chemical stability in acidic aqueous media (pH value ca. 1.2) compared to related compounds bearing electron neutral or releasing groups on the benzo part of the indane moiety.
- Compound is dissolved in an HPLC vial either in a mixture of acetonitrile/0.1 M aqueous HCl (2:3; pH ca. 1.2) or in a mixture of acetonitrile/Mcllvaine buffer pH 7.4 (2:3) to get a concentration of approximately 0.25 mg/ml.
- the vial was then transferred into an HPLC autosampler system and maintained at a temperature of 37° C.
- a first sample is taken and injected immediately into a standard HPLC system with a UV DAD detector. Further samples are injected after 2, 4, 6, 8 and 10 hours. Degradation of the compound is measured by determining the recovery rate of compound [%] for each injection using an HPLC standard gradient method.
- the recovery rate of the compounds according to the invention after 2 h at pH value of ca. 1.2 determined as described above is typically above 90%, preferably above 95%.
- the following table compares the recovery rate after 2 h at pH value of ca. 1.2 of examples described in the experimental part with the results obtained with two examples XX and XXI disclosed in WO2012072691.
- the number of the compound in the table corresponds to the number of the Example in the experimental section.
- Example XX Example XXI Recovery rate Example after 2 h 1 97.5% 2 >98% 3 97.5% 6 >98% 9 >99% 11 96.5% 12 >99% XX ⁇ 5% XXI ⁇ 5%
- IP 1 accumulation measurements using the IPOne assay system 1321 N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h before the assay in white 384-well plates in culture medium containing 10% FCS, 1% Na-Pyruvate and 400 ⁇ g/mL G418. IP 1 is assayed according to the manufacturer's description (Cisbio Bioassays, France). In brief, the assay is started by substitution of the culture medium by stimulation buffer (Hepes 10 mM, CaCl 2 1 mM, MgCl 2 0.5 mM, KCl 4.2 mM, NaCl 146 mM, glucose 5.5 mM and LiCl 50 mM, pH 7.4).
- stimulation buffer Hepes 10 mM, CaCl 2 1 mM, MgCl 2 0.5 mM, KCl 4.2 mM, NaCl 146 mM, glucose 5.5 mM and LiCl 50 mM
- Cells are stimulated for 1 h at 37° C., 5% CO 2 by addition of the compounds that are diluted in stimulation buffer containing LiCl. Assays are stopped by adding HTRF-conjugates (IP1-d2 and Anti-IP1 cryptate Tb) and lysis buffer, provided by the manufacturer. After an incubation time of 1 h at room temperature plates are measured using an EnVisionTM, Perkin Elmer. The obtained fluorescence ratios at 665/615 nM are then used to calculate the pEC 50 values using Assay Explorer 3.3 Software (Accelrys, Inc.) by interpolation using an IP 1 reference curve and subsequent sigmoidal curve fitting allowing for a variable hill slope.
- the compounds according to the invention typically have EC 50 values in the range from about 1 nM to about 10 ⁇ M, preferably less than 1 ⁇ M, more preferably less than 100 nM.
- EC 50 values for compounds according to the invention are shown in the following Table.
- the number of the compound corresponds to the number of the Example in the experimental section.
- the compounds of general formula I according to the invention are theoretically suitable for the treatment of all those diseases or conditions which may be affected or which are mediated by the activation of the G-protein-coupled receptor GPR40.
- the present invention relates to a compound of general formula I as a medicament.
- the present invention relates to the use of a compound of general formula I or a pharmaceutical composition according to this invention for the treatment and/or prevention of diseases or conditions which are mediated by the activation of the G-protein-coupled receptor GPR40 in a patient, preferably in a human.
- the present invention relates to a method for treating a disease or condition mediated by the activation of the G-protein-coupled receptor GPR40 in a mammal that includes the step of administering to a patient, preferably a human, in need of such treatment a therapeutically effective amount of a compound or a pharmaceutical composition of the present invention.
- the compounds and pharmaceutical compositions of the present invention are particularly suitable for treating diabetes mellitus, in particular Type 2 diabetes, Type 1 diabetes, complications of diabetes (such as e.g. retinopathy, nephropathy or neuropathies, diabetic foot, ulcers or macroangiopathies), metabolic acidosis or ketosis, reactive hypoglycaemia, hyperinsulinaemia, glucose metabolic disorder, insulin resistance, metabolic syndrome, dyslipidaemias of different origins, atherosclerosis and related diseases, obesity, high blood pressure, chronic heart failure, oedema and hyperuricaemia.
- diabetes mellitus in particular Type 2 diabetes, Type 1 diabetes, complications of diabetes (such as e.g. retinopathy, nephropathy or neuropathies, diabetic foot, ulcers or macroangiopathies), metabolic acidosis or ketosis, reactive hypoglycaemia, hyperinsulinaemia, glucose metabolic disorder, insulin resistance, metabolic syndrome, dyslipidaemias of different origins, atherosclerosis and related diseases, obesity, high blood pressure
- the compounds and pharmaceutical compositions of the present invention are also suitable for preventing beta-cell degeneration such as e.g. apoptosis or necrosis of pancreatic beta cells.
- the compounds and pharmaceutical compositions of the present invention are also suitable for improving or restoring the functionality of pancreatic cells, and also for increasing the number and size of pancreatic beta cells.
- the invention relates to compounds of formula I and pharmaceutical compositions according to the invention for use in preventing, delaying, slowing the progression of and/or treating metabolic diseases, particularly in improving the glycaemic control and/or beta cell function in the patient.
- the invention relates to compounds of formula I and pharmaceutical compositions according to the invention for use in preventing, delaying, slowing the progression of and/or treating type 2 diabetes, overweight, obesity, complications of diabetes and associated pathological conditions.
- compositions according to the invention are suitable for use in one or more of the following therapeutic processes:
- the compounds and pharmaceutical compositions according to the invention are suitable for the treatment of obesity, diabetes (comprising type 1 and type 2 diabetes, preferably type 2 diabetes mellitus) and/or complications of diabetes (such as for example retinopathy, nephropathy or neuropathies, diabetic foot, ulcers or macroangiopathies).
- diabetes comprising type 1 and type 2 diabetes, preferably type 2 diabetes mellitus
- complications of diabetes such as for example retinopathy, nephropathy or neuropathies, diabetic foot, ulcers or macroangiopathies.
- the compounds according to the invention are most particularly suitable for treating type 2 diabetes mellitus.
- the dose range of the compounds of general formula I applicable per day is usually from 0.001 to 10 mg per kg body weight, for example from 0.01 to 8 mg per kg body weight of the patient.
- Each dosage unit may conveniently contain from 0.1 to 1000 mg, for example 0.5 to 500 mg.
- the actual therapeutically effective amount or therapeutic dosage will of course depend on factors known by those skilled in the art such as age and weight of the patient, route of administration and severity of disease. In any case the compound or composition will be administered at dosages and in a manner which allows a therapeutically effective amount to be delivered based upon patient's unique condition.
- compositions, including any combinations with one or more additional therapeutic agents, according to the invention may be administered by oral, transdermal, inhalative, parenteral or sublingual route.
- oral or intravenous administration is preferred.
- Suitable preparations for administering the compounds of formula I, optionally in combination with one or more further therapeutic agents will be apparent to those with ordinary skill in the art and include for example tablets, pills, capsules, suppositories, lozenges, troches, solutions, syrups, elixirs, sachets, injectables, inhalatives and powders etc. Oral formulations, particularly solid forms such as e.g. tablets or capsules are preferred.
- the content of the pharmaceutically active compound(s) is advantageously in the range from 0.1 to 90 wt.-%, for example from 1 to 70 wt.-% of the composition as a whole.
- Suitable tablets may be obtained, for example, by mixing one or more compounds according to formula I with known excipients, for example inert diluents, carriers, disintegrants, adjuvants, surfactants, binders and/or lubricants.
- excipients for example inert diluents, carriers, disintegrants, adjuvants, surfactants, binders and/or lubricants.
- the tablets may also consist of several layers.
- the particular excipients, carriers and/or diluents that are suitable for the desired preparations will be familiar to the skilled man on the basis of his specialist knowledge.
- the preferred ones are those that are suitable for the particular formulation and method of administration that are desired.
- preparations or formulations according to the invention may be prepared using methods known per se that are familiar to the skilled man, such as for example by mixing or combining at least one compound of formula I according to the invention, or a pharmaceutically acceptable salt of such a compound, and one or more excipients, carriers and/or diluents.
- the compounds of the invention may further be combined with one or more, preferably one additional therapeutic agent.
- the additional therapeutic agent is selected from the group of therapeutic agents useful in the treatment of diseases or conditions described hereinbefore, in particular associated with metabolic diseases or conditions such as for example diabetes mellitus, obesity, diabetic complications, hypertension, hyperlipidemia.
- Additional therapeutic agents which are suitable for such combinations include in particular those which for example potentiate the therapeutic effect of one or more active substances with respect to one of the indications mentioned and/or which allow the dosage of one or more active substances to be reduced.
- a compound of the invention may be combined with one or more additional therapeutic agents selected from the group consisting of antidiabetic agents, agents for the treatment of overweight and/or obesity and agents for the treatment of high blood pressure, heart failure and/or atherosclerosis.
- Antidiabetic agents are for example metformin, sulphonylureas, nateglinide, repaglinide, thiazolidinediones, PPAR-(alpha, gamma or alpha/gamma) agonists or modulators, alpha-glucosidase inhibitors, DPPIV inhibitors, SGLT2-inhibitors, insulin and insulin analogues, GLP-1 and GLP-1 analogues or amylin and amylin analogues, cycloset, 11 ⁇ -HSD inhibitors.
- Other suitable combination partners are inhibitors of protein tyrosinephosphatase 1, substances that affect deregulated glucose production in the liver, such as e.g.
- glucose-6-phosphatase or fructose-1,6-bisphosphatase
- glycogen phosphorylase glycogen phosphorylase
- glucagon receptor antagonists and inhibitors of phosphoenol pyruvate carboxykinase, glycogen synthase kinase or pyruvate dehydrokinase, alpha2-antagonists, CCR-2 antagonists or glucokinase activators.
- One or more lipid lowering agents are also suitable as combination partners, such as for example HMG-CoA-reductase inhibitors, fibrates, nicotinic acid and the derivatives thereof, PPAR-(alpha, gamma or alpha/gamma) agonists or modulators, PPAR-delta agonists, ACAT inhibitors or cholesterol absorption inhibitors such as, bile acid-binding substances such as, inhibitors of ileac bile acid transport, MTP inhibitors, or HDL-raising compounds such as CETP inhibitors or ABC1 regulators.
- HMG-CoA-reductase inhibitors such as for example HMG-CoA-reductase inhibitors, fibrates, nicotinic acid and the derivatives thereof, PPAR-(alpha, gamma or alpha/gamma) agonists or modulators, PPAR-delta agonists, ACAT inhibitors or cholesterol absorption inhibitors such as, bile acid-binding substances such
- Therapeutic agents for the treatment of overweight and/or obesity are for example antagonists of the cannabinoid1 receptor, MCH-1 receptor antagonists, MC4 receptor agonists, NPY5 or NPY2 antagonists, ⁇ 3-agonists, leptin or leptin mimetics, agonists of the 5HT2c receptor.
- Therapeutic agents for the treatment of high blood pressure, chronic heart failure and/or atherosclerosis are for example A-II antagonists or ACE inhibitors, ECE inhibitors, diuretics, ⁇ -blockers, Ca-antagonists, centrally acting antihypertensives, antagonists of the alpha-2-adrenergic receptor, inhibitors of neutral endopeptidase, thrombocyte aggregation inhibitors and others or combinations thereof are suitable.
- Angiotensin II receptor antagonists are preferably used for the treatment or prevention of high blood pressure and complications of diabetes, often combined with a diuretic such as hydrochlorothiazide.
- the dosage for the combination partners mentioned above is usually 1/5 of the lowest dose normally recommended up to 1/1 of the normally recommended dose.
- compounds of the present invention and/or pharmaceutical compositions comprising a compound of the present invention optionally in combination with one or more additional therapeutic agents are administered in conjunction with exercise and/or a diet.
- this invention relates to the use of a compound according to the invention in combination with one or more additional therapeutic agents described hereinbefore and hereinafter for the treatment of diseases or conditions which may be affected or which are mediated by the activation of the G-protein-coupled receptor GPR40, in particular diseases or conditions as described hereinbefore and hereinafter.
- the present invention relates a method for treating a disease or condition mediated by the activation of the G-protein-coupled receptor GPR40 in a patient that includes the step of administering to the patient, preferably a human, in need of such treatment a therapeutically effective amount of a compound of the present invention in combination with a therapeutically effective amount of one or more additional therapeutic agents described in hereinbefore and hereinafter,
- the compound according to the invention and the one or more additional therapeutic agents may both be present together in one formulation, for example a tablet or capsule, or separately in two identical or different formulations, for example as a so-called kit-of-parts.
- this invention relates to a pharmaceutical composition which comprises a compound according to the invention and one or more additional therapeutic agents described hereinbefore and hereinafter, optionally together with one or more inert carriers and/or diluents.
- ambient temperature and “room temperature” are used interchangeably and designate a temperature of about 20° C.
- the enantiomers may be separated by SFC on chiral phase (column: Daicel ADH, 5 ⁇ m, 250 mm ⁇ 20 mm; eluent: scCO 2 /(isopropanol+0.2% diethylamine) 80:20, 70 mL/min):
- the pure enantiomer may be obtained as described in WO 2008001931.
- Formic acid (8.1 mL) is added to a solution of triethylamine (25.6 mL) in dichloromethane (50 mL) chilled in an ice bath.
- 4-Bromo-7-fluoro-2,3-dihydro-1H-inden-1-one (14.0 g) is added, the solution is warmed to room temperature, and the flask is purged with argon for 5 min.
- Chloro ⁇ [(1S,2S)-( ⁇ )-2-amino-1,2-diphenylethyl](4-toluenesulfonyl)amido ⁇ -(mesitylene)ruthenium(II) (0.85 g; alternatively, the catalyst is formed in situ from dichloro(p-cymene)-ruthenium(II) dimer and N-[(1S,2S)-2-amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide) is added, and the mixture is stirred at room temperature for 16 h. Water is added and the resulting mixture is extracted with dichloromethane.
- Aqueous hydrogen peroxide solution (35%, 3.7 mL) is added dropwise to a solution of ⁇ (S)-6-[(R)-7-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl ⁇ -acetic acid methyl ester (5.0 g) in acetic acid (30 mL) chilled in an ice bath. The solution is stirred with cooling for 0.5 h and at room temperature for another 2 h. Ice-cold water (50 mL) and 2 N aqueous NaOH solution (20 mL) are added, and the mixture is stirred at room temperature overnight.
- Triethylamine (726 mg) is added to a mixture of ⁇ (S)-6-[(R)-7-fluoro-4-hydroxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl ⁇ -acetic acid methyl ester (400 mg), 4-(benzyloxy)phenylboronic acid (509 mg), freshly activated molecular sieves 4A (6.0 g), copper(II) acetate (204 mg) and dichloromethane (19.5 mL) at room temperature. The flask is purged with O 2 and sealed. The reaction mixture is stirred under an O 2 atmosphere (1 bar) at room temperature over night. The mixture is diluted with dichloromethane, filtered and concentrated.
- the title compound is prepared from ⁇ (S)-6-[(R)-7-fluoro-4-hydroxy-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl ⁇ -acetic acid methyl ester and 4-(6-fluoro-pyridin-3-yloxy)-2-methyl-butan-2-ol in N-methyl-2-pyrrolidinon following a procedure analogous to that described for Intermediate 20.
- the crude product is used for the next reaction step without further purification.
- the title compound is prepared from ⁇ (S)-6-[(R)-7-fluoro-4-(5-iodo-pyridin-2-yloxy)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl ⁇ -acetic acid methyl ester and (S)-tetrahydro-furan-3-ol following a procedure analogous to that described for Intermediate 25.
- the crude product is used for the next reaction step without further purification.
- a 2 M aqueous Na 2 CO 3 solution (72 ⁇ L) is added to a mixture of ⁇ (S)-6-[(R)-4-(4-bromo-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl ⁇ -acetic acid methyl ester (37 mg), 2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole (19 mg), and [1,1′-bis(diphenylphosphino)-ferrocene]-dichloropalladium(II) (3.5 mg), in 1,4-dioxane (2 mL). The reaction mixture is heated to 100° C.
- the title compound is prepared from [(S)-6- ⁇ (R)-7-fluoro-4-[5-(4-hydroxy-4-methyl-pent-1-enyl)-pyridin-2-yloxy]-indan-1-yloxy ⁇ -2,3-dihydro-benzofuran-3-yl]-acetic acid methyl ester by hydrogenation in the presence of 10% palladium on carbon in methanol at room temperature. The crude product is used for the next reaction step without further purification.
- Step 1 ((S)-6- ⁇ (R)-4-[4-(3,6-Dihydro-2H-pyran-4-yl)-phenoxy]-7-fluoro-indan-1-yloxy ⁇ -2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester
- Step 2 ((S)-6- ⁇ (R)-7-Fluoro-4-[4-(tetrahydro-2H-pyran-4-yl)phenoxy]-indan-1-yloxy ⁇ -2,3-dihydrobenzofuran-3-yl)-acetic acid methyl ester
- Step 2 ((S)-6- ⁇ (R)-7-Fluoro-4-[4-(4-hydroxy-4-methylpentyl)phenoxy]-indan-1-yloxy ⁇ -2,3-dihydrobenzofuran-3-yl)-acetic acid methyl ester
- the title compound is prepared from (R)-7-fluoro-1-[(S)-3-(2-methoxy-2-oxoethyl)-2,3-dihydrobenzofuran-6-yloxy ⁇ -2,3-dihydro-1H-inden-4-ylboronic acid and 4-(2-methyl-thiazol-4-yl)-phenol following a procedure analogous to that described for Intermediate 6.
- the crude product is used for the next reaction step without further purification.
- Step 2 4-[2,5-Difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-2-methyl-butan-2-ol
- Step 2 [(S)-6-((R)-7-Fluoro-4- ⁇ 4-[(tetrahydro-2H-pyran-4-yl)methyl]phenoxy ⁇ -indan-1-yloxy)-2,3-dihydrobenzofuran-3-yl]-acetic acid methyl ester
- Step 1 ⁇ (S)-6-[(R)-4-(4-Benzyloxy-3-fluoro-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl ⁇ -acetic acid methyl ester
- Step 2 ⁇ (S)-6-[(R)-7-Fluoro-4-(3-fluoro-4-hydroxy-phenoxy)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl ⁇ -acetic acid methyl ester
- the title compound is prepared from (R)-7-fluoro-1-[(S)-3-(2-methoxy-2-oxoethyl)-2,3-dihydrobenzofuran-6-yloxy ⁇ -2,3-dihydro-1H-inden-4-ylboronic acid and 4-(1-methyl-1H-imidazol-2-yl)-phenol following a procedure analogous to that described for Intermediate 6.
- the crude product is used for the next reaction step without further purification.
- Step 3 2-[2,5-Difluoro-4-(3-methanesulfonyl-propoxy)-phenyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
- Step 1 ⁇ (S)-6-[(R)-4-(5-Bromo-2-cyano-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydrobenzofuran-3-yl ⁇ -acetic acid methyl ester
- Step 2 ((S)-6- ⁇ (R)-4-[2-Cyano-5-(4-hydroxy-4-methylpentyl)-phenoxy]-7-fluoro-indan-1-yloxy ⁇ -2,3-dihydrobenzofuran-3-yl)-acetic acid methyl ester
- Step 1 ((S)-6- ⁇ (R)-4-[2-Cyano-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-7-fluoro-indan-1-yloxy ⁇ -2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester
- Step 2 ⁇ (S)-6-[(R)-4-(2-Cyano-5-hydroxy-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydrobenzofuran-3-yl ⁇ -acetic acid methyl ester
- Step 1 4-(tert-Butyl-dimethyl-silanyloxy)-3-cyano-phenyl-boronic acid
- Triisopropyl borate (1.77 mL) is added to a solution of 5-bromo-2-(tert-butyl-dimethyl-silanyloxy)-benzonitrile (800 mg) in tetrahydrofuran (12 mL) and the mixture is cooled to ⁇ 78° C.
- n-Butyllithium (15% in hexane; 1.92 mL) is added and the reaction mixture is stirred at ⁇ 78° C. for 3 h. More n-butyllithium (15% in hexane; 0.2 mL) is added and the mixture is allowed to warm to ⁇ 50° C., and stirred at this temperature for 1.5 h.
- Step 2 ((S)-6- ⁇ (R)-4-[4-(tert-Butyl-dimethyl-silanyloxy)-3-cyano-phenoxy]-7-fluoro-indan-1-yloxy ⁇ -2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester
- Step 3 ⁇ (S)-6-[(R)-4-(3-Cyano-4-hydroxy-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydrobenzofuran-3-yl ⁇ -acetic acid methyl ester
- the title compound is prepared from ((S)-6- ⁇ (R)-4-[4-(tert-butyl-dimethyl-silanyloxy)-3-cyano-phenoxy]-7-fluoro-indan-1-yloxy ⁇ -2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester by treatment with tetrabutylammonium fluoride in tetrahydrofuran at room temperature.
- Step 1 ⁇ (S)-6-[(R)-7-Fluoro-4-(5-bromo-2-fluoro-phenoxy)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl ⁇ -acetic acid methyl ester
- Step 2 ((S)-6- ⁇ (R)-7-Fluoro-4-[2-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-indan-1-yloxy ⁇ -2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester
- Step 3 ⁇ (S)-6-[(R)-7-Fluoro-4-(2-fluoro-5-hydroxy-phenoxy)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl ⁇ -acetic acid methyl ester
- Step 1 ⁇ (S)-6-[(R)-4-(4-Benzyloxy-2-cyano-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl ⁇ -acetic acid methyl ester
- Step 2 ⁇ (S)-6-[(R)-4-(2-Cyano-4-hydroxy-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl ⁇ -acetic acid methyl ester
- Step 1 ⁇ (S)-6-[(R)-7-Fluoro-4-(4-bromo-2-fluoro-phenoxy)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl ⁇ -acetic acid methyl ester
- Step 2 ((S)-6- ⁇ (R)-7-Fluoro-4-[2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-indan-1-yloxy ⁇ -2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester
- Step 3 ⁇ (S)-6-[(R)-7-Fluoro-4-(2-fluoro-4-hydroxy-phenoxy)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl ⁇ -acetic acid methyl ester
- the title compound is prepared from ⁇ (S)-6-[(R)-4-(4-cyano-3-hydroxy-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl ⁇ -acetic acid methyl ester and 4-bromo-tetrahydropyran following a procedure analogous to that described for Intermediate 8.
- the crude product is used for the next reaction step without further purification.
- the title compound is prepared from ⁇ (S)-6-[(R)-4-(4-cyano-3-hydroxy-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl ⁇ -acetic acid methyl ester and isobutylene oxide in N,N-dimethylformamide in the presence of Cs 2 CO 3 at 80° C. The crude product is used for the next reaction step without further purification.
- Step 1 ((S)-6- ⁇ (R)-4-[2-Cyano-4-(3-hydroxy-3-methyl-but-1-enyl)-phenoxy]-7-fluoro-indan-1-yloxy ⁇ -2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester
- Step 2 ((S)-6- ⁇ (R)-4-[2-Cyano-4-(3-hydroxy-3-methylbutyl)phenoxy]-7-fluoro-indan-1-yloxy ⁇ -2,3-dihydrobenzofuran-3-yl)-acetic acid methyl ester
- Step 1 4-[(R)-7-Fluoro-1-((S)-3-methoxycarbonylmethyl-2,3-dihydro-benzofuran-6-yloxy)-indan-4-yloxy]-benzoic acid benzyl ester
- Step 2 4-[(R)-7-Fluoro-1-((S)-3-methoxycarbonylmethyl-2,3-dihydro-benzofuran-6-yloxy)-indan-4-yloxy]-benzoic acid
- the title compound is prepared from 4-[(R)-7-fluoro-1-((S)-3-methoxycarbonylmethyl-2,3-dihydro-benzofuran-6-yloxy)-indan-4-yloxy]-benzoic acid benzyl ester by hydrogenation in the presence of 10% palladium on carbon in ethyl acetate at room temperature.
- Step 1 ((S)-6- ⁇ (R)-4-[2-Cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-7-fluoro-indan-1-yloxy ⁇ -2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester
- Step 2 ((S)-6- ⁇ (R)-4-[2-Cyano-4-(2,6-dimethylpyridin-4-yl)phenoxy)]-7-fluoro-indan-1-yloxy) ⁇ -2,3-dihydrobenzofuran-3-yl)-acetic acid methyl ester
- the title compound is prepared from ((S)-6- ⁇ (R)-4-[2-cyano-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-7-fluoro-indan-1-yloxy ⁇ -2,3-dihydro-benzofuran-3-yl)-acetic acid methyl ester and 2-bromo-6-methyl-pyridine following a procedure analogous to that described for Intermediate 83, using [1,1′-bis(diphenylphosphino)-ferrocene]-dichloropalladium(II) as catalyst.
- Step 1 ⁇ 6-[4-(2-Cyano-4-vinyl-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl ⁇ -acetic acid methyl ester
- Step 2 ⁇ (S)-6-[(R)-4-(2-Cyano-4-formyl-phenoxy)-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl ⁇ -acetic acid methyl ester
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15/097,857 US9597310B2 (en) | 2012-12-07 | 2016-04-13 | Indanyloxydihydrobenzofuranylacetic acids |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12196011 | 2012-12-07 | ||
EP12196011.6 | 2012-12-07 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/097,857 Continuation US9597310B2 (en) | 2012-12-07 | 2016-04-13 | Indanyloxydihydrobenzofuranylacetic acids |
Publications (1)
Publication Number | Publication Date |
---|---|
US20140163025A1 true US20140163025A1 (en) | 2014-06-12 |
Family
ID=47290800
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/093,583 Abandoned US20140163025A1 (en) | 2012-12-07 | 2013-12-02 | Indanyloxydihydrobenzofuranylacetic acids |
US15/097,857 Active US9597310B2 (en) | 2012-12-07 | 2016-04-13 | Indanyloxydihydrobenzofuranylacetic acids |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/097,857 Active US9597310B2 (en) | 2012-12-07 | 2016-04-13 | Indanyloxydihydrobenzofuranylacetic acids |
Country Status (7)
Country | Link |
---|---|
US (2) | US20140163025A1 (ja) |
EP (1) | EP2928886B1 (ja) |
JP (1) | JP6283862B2 (ja) |
AR (1) | AR093864A1 (ja) |
TW (1) | TW201439076A (ja) |
UY (1) | UY35171A (ja) |
WO (1) | WO2014086712A1 (ja) |
Cited By (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104177320A (zh) * | 2014-08-27 | 2014-12-03 | 广东东阳光药业有限公司 | 新型脲取代联苯类化合物及其组合物及用途 |
WO2015097713A1 (en) | 2013-11-14 | 2015-07-02 | Cadila Healthcare Limited | Novel heterocyclic compounds |
US20160251307A1 (en) * | 2013-09-09 | 2016-09-01 | Peloton Therapeutics, Inc. | Aryl ethers and uses thereof |
US9597310B2 (en) | 2012-12-07 | 2017-03-21 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
WO2017186693A1 (en) * | 2016-04-29 | 2017-11-02 | Bayer Pharma Aktiengesellschaft | Synthesis of indazoles |
US9884843B2 (en) | 2013-12-16 | 2018-02-06 | Peloton Therapeutics, Inc. | Cyclic sulfone and sulfoximine analogs and uses thereof |
WO2018167800A1 (en) * | 2017-03-13 | 2018-09-20 | Impetis Biosciences Limited | Fused bicyclic compounds, compositions and applications thereof |
US10155726B2 (en) | 2015-03-11 | 2018-12-18 | Peloton Therapeutics, Inc. | Substituted pyridines and uses thereof |
US10278942B2 (en) | 2015-03-11 | 2019-05-07 | Peloton Therapeutics, Inc. | Compositions for use in treating pulmonary arterial hypertension |
US10335388B2 (en) | 2015-04-17 | 2019-07-02 | Peloton Therapeutics, Inc. | Combination therapy of a HIF-2-alpha inhibitor and an immunotherapeutic agent and uses thereof |
US10512626B2 (en) | 2015-03-11 | 2019-12-24 | Peloton Therapeautics, Inc. | Compositions for use in treating glioblastoma |
US10550127B1 (en) | 2017-02-08 | 2020-02-04 | Boehringer Ingelheim International Gmbh | Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes |
US10603317B2 (en) | 2017-01-26 | 2020-03-31 | Boehringer Ingelheim International Gmbh | Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
EA035867B1 (ru) * | 2016-04-29 | 2020-08-24 | Байер Фарма Акциенгезельшафт | Синтез индазолов |
US10793530B2 (en) | 2017-01-26 | 2020-10-06 | Boehringer Ingelheim International Gmbh | Benzylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
US10807948B2 (en) | 2015-03-11 | 2020-10-20 | Peloton Therapeutics, Inc. | Aromatic compounds and uses thereof |
US10913720B2 (en) | 2017-01-26 | 2021-02-09 | Boehringer Ingelheim International Gmbh | Benzyloxypyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
US10919859B2 (en) | 2017-01-26 | 2021-02-16 | Boehringer Ingelheim International Gmbh | Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3091015C (en) | 2018-02-13 | 2023-02-21 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
US10899735B2 (en) | 2018-04-19 | 2021-01-26 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
JP7105359B2 (ja) | 2018-07-13 | 2022-07-22 | ギリアード サイエンシーズ, インコーポレイテッド | Pd-1/pd-l1阻害剤 |
WO2020086556A1 (en) | 2018-10-24 | 2020-04-30 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
AU2020363377A1 (en) | 2019-10-07 | 2022-04-21 | Kallyope, Inc. | GPR119 agonists |
IL298306A (en) | 2020-05-19 | 2023-01-01 | Kallyope Inc | ampk operators |
CA3183575A1 (en) | 2020-06-26 | 2021-12-30 | Iyassu Sebhat | Ampk activators |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1559422B1 (en) | 2002-11-08 | 2014-04-30 | Takeda Pharmaceutical Company Limited | Receptor function controlling agent |
US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
JP4805552B2 (ja) * | 2003-05-30 | 2011-11-02 | 武田薬品工業株式会社 | 縮合環化合物 |
EP1630152A4 (en) | 2003-05-30 | 2009-09-23 | Takeda Pharmaceutical | CONNECTION WITH CONDENSED RING |
CA2560111A1 (en) * | 2004-03-15 | 2005-09-22 | Takeda Pharmaceutical Company Limited | Aminophenylpropanoic acid derivative |
CA2621949A1 (en) | 2005-09-14 | 2007-03-22 | Amgen Inc. | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
AU2007233035A1 (en) | 2006-03-30 | 2007-10-11 | Asahi Kasei Pharma Corporation | Substituted bicyclic derivative and use thereof |
RS53230B (en) * | 2006-06-27 | 2014-08-29 | Takeda Pharmaceutical Company Limited | CONDENSED CYCLICAL UNITS AS GPR40 RECEPTOR MODULATORS |
EP2289868B1 (en) * | 2008-06-25 | 2014-08-13 | Daiichi Sankyo Company, Limited | Carboxylic acid compound |
US8748462B2 (en) | 2008-10-15 | 2014-06-10 | Amgen Inc. | Spirocyclic GPR40 modulators |
US20120172351A1 (en) | 2009-06-09 | 2012-07-05 | Nobuyuki Negoro | Novel fused cyclic compound and use thereof |
TW201643169A (zh) | 2010-07-09 | 2016-12-16 | 艾伯維股份有限公司 | 作為s1p調節劑的螺-哌啶衍生物 |
UY33758A (es) | 2010-12-01 | 2012-06-29 | Boehringer Ingelheim Int | Acidos indaniloxidihidrobenzofuranilaceticos |
KR20150088878A (ko) | 2012-11-28 | 2015-08-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 신규한 인다닐옥시디하이드로벤조푸라닐아세트산 |
US20140163025A1 (en) | 2012-12-07 | 2014-06-12 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
-
2013
- 2013-12-02 US US14/093,583 patent/US20140163025A1/en not_active Abandoned
- 2013-12-02 WO PCT/EP2013/075238 patent/WO2014086712A1/en active Application Filing
- 2013-12-02 EP EP13802010.2A patent/EP2928886B1/en active Active
- 2013-12-02 JP JP2015545760A patent/JP6283862B2/ja active Active
- 2013-12-05 UY UY0001035171A patent/UY35171A/es unknown
- 2013-12-06 TW TW102144980A patent/TW201439076A/zh unknown
- 2013-12-06 AR ARP130104569A patent/AR093864A1/es unknown
-
2016
- 2016-04-13 US US15/097,857 patent/US9597310B2/en active Active
Cited By (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9597310B2 (en) | 2012-12-07 | 2017-03-21 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
US9896418B2 (en) | 2013-09-09 | 2018-02-20 | Peloton Therapeutics, Inc. | Aryl ethers and uses thereof |
US20160251307A1 (en) * | 2013-09-09 | 2016-09-01 | Peloton Therapeutics, Inc. | Aryl ethers and uses thereof |
USRE49948E1 (en) | 2013-09-09 | 2024-04-30 | Peloton Therapeutics, Inc. | Aryl ethers and uses thereof |
US9908845B2 (en) * | 2013-09-09 | 2018-03-06 | Peloton Therapeutics, Inc. | Aryl ethers and uses thereof |
US9969689B2 (en) | 2013-09-09 | 2018-05-15 | Peloton Therapeutics, Inc. | Aryl ethers and uses thereof |
US10597366B2 (en) | 2013-09-09 | 2020-03-24 | Peloton Therapeutics, Inc. | Aryl ethers and uses thereof |
US10144711B2 (en) | 2013-09-09 | 2018-12-04 | Peloton Therapeutics, Inc. | Aryl ethers and uses thereof |
WO2015097713A1 (en) | 2013-11-14 | 2015-07-02 | Cadila Healthcare Limited | Novel heterocyclic compounds |
US10246470B2 (en) | 2013-11-14 | 2019-04-02 | Cadila Healthcare Limited | Heterocyclic compounds |
US10011609B2 (en) | 2013-11-14 | 2018-07-03 | Cadila Healthcare Limited | Heterocyclic compounds |
US9884843B2 (en) | 2013-12-16 | 2018-02-06 | Peloton Therapeutics, Inc. | Cyclic sulfone and sulfoximine analogs and uses thereof |
CN104177320A (zh) * | 2014-08-27 | 2014-12-03 | 广东东阳光药业有限公司 | 新型脲取代联苯类化合物及其组合物及用途 |
US10278942B2 (en) | 2015-03-11 | 2019-05-07 | Peloton Therapeutics, Inc. | Compositions for use in treating pulmonary arterial hypertension |
US10807948B2 (en) | 2015-03-11 | 2020-10-20 | Peloton Therapeutics, Inc. | Aromatic compounds and uses thereof |
US10512626B2 (en) | 2015-03-11 | 2019-12-24 | Peloton Therapeautics, Inc. | Compositions for use in treating glioblastoma |
US10155726B2 (en) | 2015-03-11 | 2018-12-18 | Peloton Therapeutics, Inc. | Substituted pyridines and uses thereof |
US10786480B2 (en) | 2015-04-17 | 2020-09-29 | Peloton Therapeutics, Inc. | Combination therapy of a HIF-2-α inhibitor and an immunotherapeutic agent and uses thereof |
US10335388B2 (en) | 2015-04-17 | 2019-07-02 | Peloton Therapeutics, Inc. | Combination therapy of a HIF-2-alpha inhibitor and an immunotherapeutic agent and uses thereof |
KR20180137498A (ko) * | 2016-04-29 | 2018-12-27 | 바이엘 파마 악티엔게젤샤프트 | 인다졸의 합성 |
US10633365B2 (en) | 2016-04-29 | 2020-04-28 | Bayer Pharma Aktiengesellschaft | Synthesis of indazoles |
EA035867B1 (ru) * | 2016-04-29 | 2020-08-24 | Байер Фарма Акциенгезельшафт | Синтез индазолов |
CN109071491A (zh) * | 2016-04-29 | 2018-12-21 | 拜耳医药股份有限公司 | 吲唑的合成 |
KR102409105B1 (ko) | 2016-04-29 | 2022-06-16 | 바이엘 파마 악티엔게젤샤프트 | 인다졸의 합성 |
WO2017186693A1 (en) * | 2016-04-29 | 2017-11-02 | Bayer Pharma Aktiengesellschaft | Synthesis of indazoles |
US10603317B2 (en) | 2017-01-26 | 2020-03-31 | Boehringer Ingelheim International Gmbh | Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
US10793530B2 (en) | 2017-01-26 | 2020-10-06 | Boehringer Ingelheim International Gmbh | Benzylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
US10913720B2 (en) | 2017-01-26 | 2021-02-09 | Boehringer Ingelheim International Gmbh | Benzyloxypyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
US10919859B2 (en) | 2017-01-26 | 2021-02-16 | Boehringer Ingelheim International Gmbh | Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
US10550127B1 (en) | 2017-02-08 | 2020-02-04 | Boehringer Ingelheim International Gmbh | Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes |
WO2018167800A1 (en) * | 2017-03-13 | 2018-09-20 | Impetis Biosciences Limited | Fused bicyclic compounds, compositions and applications thereof |
US11098026B2 (en) | 2017-03-13 | 2021-08-24 | Impetis Biosciences Limited | Fused bicyclic compounds, compositions and applications thereof |
Also Published As
Publication number | Publication date |
---|---|
US20160235706A1 (en) | 2016-08-18 |
AR093864A1 (es) | 2015-06-24 |
US9597310B2 (en) | 2017-03-21 |
UY35171A (es) | 2014-06-30 |
WO2014086712A1 (en) | 2014-06-12 |
EP2928886B1 (en) | 2016-11-02 |
JP6283862B2 (ja) | 2018-02-28 |
EP2928886A1 (en) | 2015-10-14 |
JP2016505551A (ja) | 2016-02-25 |
TW201439076A (zh) | 2014-10-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9597310B2 (en) | Indanyloxydihydrobenzofuranylacetic acids | |
US8815864B2 (en) | Indanyloxydihydrobenzofuranylacetic acids | |
US8642585B2 (en) | Indanyloxydihydrobenzofuranylacetic acids | |
US10913720B2 (en) | Benzyloxypyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof | |
US8633182B2 (en) | Indanyloxyphenylcyclopropanecarboxylic acids | |
US10793530B2 (en) | Benzylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof | |
US10919859B2 (en) | Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof | |
US10550127B1 (en) | Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes | |
US10603317B2 (en) | Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof | |
US10538490B2 (en) | Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof | |
EP3347358B1 (en) | [{[2,3-dihydro-1h-inden-1-yl]amino}-2h,3h-furo[3,2-b]pyridin-3-yl]acetic acids, pharmaceutical compositions and uses thereof | |
US8809376B2 (en) | Indanyloxydihydrobenzofuranylacetic acids | |
US9617251B2 (en) | Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof | |
US20180208560A1 (en) | Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof | |
OA17286A (en) | Exendin-4 derivatives as dual GLP1/glucagon agonists. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: BOEHRINGER INGELHEIM INTERNATIONAL GMBH, GERMANY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ECKHARDT, MATTHIAS;LANGKOPF, ELKE;WAGNER, HOLGER;AND OTHERS;SIGNING DATES FROM 20140211 TO 20140225;REEL/FRAME:032309/0381 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO PAY ISSUE FEE |