US20140134073A1 - Screening device for analysis of bodily fluids - Google Patents

Screening device for analysis of bodily fluids Download PDF

Info

Publication number
US20140134073A1
US20140134073A1 US14/079,558 US201314079558A US2014134073A1 US 20140134073 A1 US20140134073 A1 US 20140134073A1 US 201314079558 A US201314079558 A US 201314079558A US 2014134073 A1 US2014134073 A1 US 2014134073A1
Authority
US
United States
Prior art keywords
cup
holder
passage
sampling
face
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US14/079,558
Other languages
English (en)
Inventor
Kevin S. Fuller
Wayde J. ALTENDORF
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Premier Biotech Inc
Original Assignee
Premier Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Premier Biotech Inc filed Critical Premier Biotech Inc
Priority to US14/079,558 priority Critical patent/US20140134073A1/en
Publication of US20140134073A1 publication Critical patent/US20140134073A1/en
Priority to US14/834,534 priority patent/US20160151779A1/en
Priority to US16/008,720 priority patent/US10744507B2/en
Priority to US16/875,583 priority patent/US20200276577A1/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5029—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures using swabs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/18—Devices for withdrawing samples in the liquid or fluent state with provision for splitting samples into portions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0609—Holders integrated in container to position an object
    • B01L2300/0618—Holders integrated in container to position an object for removable separation walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0663—Whole sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0672—Integrated piercing tool
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting

Definitions

  • This application is directed generally to devices and methods for analysis of the presence of constituents in fluids, and more specifically to devices and methods for analysis of the presence of constituents in bodily fluids for drug test screening.
  • Various drug screening devices are known for testing a sample of bodily fluids for the presence of certain constituents. These devices typically include a container for receiving a bodily fluid from a delivery device, and a plurality of reagent test strips arranged to contact the bodily fluid, with each test strip being sensitive to a particular constituent of interest.
  • the targeted constituents for screening can range from controlled substances such as alcohol and marijuana to illegal substances such as cocaine and methamphetamines.
  • Various embodiments of the invention include a device and method for adequately distributing a sample of bodily fluid among a plurality of test strips and preventing maldistribution of sampled fluid that can lead to an invalid test result, all while displaying the test results on a single face of the screening device. Certain embodiments also enable a slight and passive pressurization of a sampling chamber to augment the wicking or capillary action of the sampled fluid along the test strips.
  • various embodiments of the invention include a container or cup having a first or “viewing” side through which all of the test strips can be viewed.
  • the bottom of the cup is inclined and intersects the viewing side along a junction line that constitutes the lowest portion of the cavity within the cup where the bodily fluid collects.
  • the test strips are oriented so that the detection end proximate the junction line for in contact with the bodily fluid that collects at the low portion of the cavity.
  • a three-dimensional gasket is implemented to provide certain sealing and pressurization advantages.
  • the three-dimensional gasket can be made of a soft, pliable material to provide a sealing surface between the gasket and the cup and to provide a seal between a sampling stem that is inserted through the gasket.
  • the pliable material can also cause the three-dimensional gasket to act as a diaphragm; when the sampling stem is inserted into the three-dimensional gasket, the displaced air causes the three-dimensional gasket to expand (as would a diaphragm), thereby causing the air contained by the three-dimensional gasket to become slightly pressurized.
  • the pressurization can assist in the diffusion of the bodily fluid into the test strips, thus augmenting the capillary action between the bodily fluid and the test strip.
  • the device can also provide barriers between the detection ends of adjacent test strips to prevent more absorbent or faster absorbing test strips from drawing test fluid away from less absorbent or slower absorbing test strips.
  • a feature and advantage of embodiments of the invention is a specimen sampling device for saliva where the saliva is absorbed in a sponge, is squeezed into a saliva pathway of a specimen container, the saliva pathway is pressurized urging the saliva into engagement with a plurality of sample test strips.
  • a vent may be provided downstream of where the saliva engages the test strips.
  • the plurality of test strips are each positioned in a plurality of recesses in a row, the recesses having an overfill level whereby fluid that overflows one recess flows into an adjacent recess.
  • the pressurization may be provided by a stem attached to the sponge, the stem having a sliding plunger member.
  • the pressurization may be provided by a separate manual squeeze or push pump as part of the specimen sampling device.
  • An additional feature and advantage of embodiments of the invention is a specimen sampling device for saliva where the saliva is absorbed in a sponge, is squeezed into a saliva pathway of a specimen container, the saliva pathway leading to a plurality of sample test reservoirs, each with test strip extending therein, a gasket with a separate aperture for each respective test strip, the gasket providing sealing between the saliva pathway including and the reservoirs and regions of the container above the saliva pathway thereby preventing unintended migration of the saliva upward.
  • FIG. 3 is a sectional view of the cup of FIG. 2 ;
  • FIG. 4 is a perspective view of a test strip and sampling stem holder of FIG. 1 in an embodiment of the invention
  • FIG. 7 is a perspective view of the bottom of the three-dimensional gasket of FIG. 6 ;
  • FIG. 8 is a perspective view of a test strip
  • FIG. 9 is a perspective view of a sampling stem of FIG. 1 in an embodiment of the invention.
  • FIG. 10 is a perspective cutaway view of the holder and three-dimensional gasket of FIG. 1 in assembly;
  • FIG. 11 is a sectional view of the cup, holder and three-dimensional gasket of FIG. 1 in assembly.
  • FIG. 12 is a perspective cutaway view of the cup, holder and three-dimensional gasket of FIG. 1 in assembly.
  • the screening device includes a container or cup 22 , a test strip and sampling stem holder 24 (hereinafter “holder 24 ”), a three-dimensional gasket 26 and a sampling stem 28 .
  • the cup 22 is depicted in isolation in an embodiment of the invention.
  • the cup 22 includes a plurality of sides 32 ′ and 34 that extend upward from a containment bottom 38 to form a continuous upper edge 36 , the sides 32 , 34 and containment bottom 38 defining a cavity 42 .
  • the sides 32 and 34 can also extend below the containment bottom 38 to establish a base portion 40 with a lower edge 41 registers the testing assembly 20 in an upright position.
  • a first of the sides (side 32 in FIGS. 2 and 3 ) can be substantially planar.
  • the containment bottom 38 defines an inclined surface 44 that intersects the plurality of sides 32 and 34 .
  • the inclined surface 44 intersects the first side 32 along a junction line 46 , defining an acute angle ⁇ between the first side 32 and the inclined surface 44 .
  • the junction line 46 is the lowermost extremity of the cavity 42 when the cup 22 is in the upright position.
  • the inclined surface 44 is depicted as being substantially planar, it is noted that the inclined surface 44 is not limited to a planar configuration.
  • the inclined surface could also be convex, with a steeper slope at the junction line 46 than at other locations on the inclined surface.
  • the inclined surface could be concave, with a more gradual slope at the junction line 46 than at other locations.
  • the containment bottom 38 can further include a pedestal portion 48 that extends from the inclined surface 44 into the cavity 42 .
  • the pedestal portion 48 can include a top face 49 having a perimeter 50 .
  • a securing structure 51 such as a point or barb (as depicted in FIG. 3 ), can be included on or as part of the top face 49 of the pedestal portion.
  • cup 22 can also include a syringe access port 53 located proximate a lower corner of the cup 22 .
  • the syringe access port comprises a region where the thickness of the cup 22 is thinned to enable manual puncturing with a syringe.
  • the cup 22 can be fabricated from a variety of materials available to the artisan, including but not limited to polycarbonate, styrene-butadiene copolymers (SBCs) such as K-RESIN, and clear styrene.
  • SBCs styrene-butadiene copolymers
  • the holder 24 is depicted in isolation in an embodiment of the invention.
  • the holder 24 includes a cap portion 52 having an access port 54 formed therein.
  • the holder 24 also includes a through passage structure 56 that defines a through passage 58 that passes through the holder 24 .
  • the through passage structure 56 includes a proximal end 60 and a distal end 62 , each being concentric about an insertion axis 64 .
  • the proximal end 60 of the through passage structure 56 includes the access port 54 .
  • the through passage structure 56 can comprise a hollow tube that depends from the cap portion 52 (as depicted), or a bore that extends through a substantially solid holder 24 .
  • the holder 24 also includes a planar face 66 that extends downward from the cap portion 52 .
  • the planar face 66 includes a plurality of parallel ribs 68 that define a plurality of elongate channels 72 .
  • the elongate channels 72 each define a channel axis 74 .
  • the holder 24 can be fabricated from a variety of materials available to the artisan, including but not limited to polycarbonate, styrene and acrylonitrile butadiene styrene (ABS).
  • ABS acrylonitrile butadiene styrene
  • the three-dimensional gasket 26 is depicted in an embodiment of the invention.
  • the three-dimensional gasket 26 includes a passage extension structure 82 that defines an extended passage 84 and a diaphragm portion 86 that depends from and extends radially outward from the passage extension structure 82 .
  • a perimeter structure 88 of the three-dimensional gasket 26 surrounds and depends from the diaphragm portion 86 , the perimeter structure 88 having a lower face 92 that extends below the diaphragm portion 86 .
  • the three-dimensional gasket can also include a notch 91 that, upon assembly, aligns with the syringe access port 53 of the cup, enabling easy access to the chamber 150 .
  • the three-dimensional gasket 26 can also include guide tabs 93 that assist in guiding, registering and seating the three-dimensional gasket into the holder 24 during assembly.
  • the perimeter structure 88 includes a front portion 90 having an outer face 94 and an inner face 96 .
  • the outer face 94 is adapted to contact an inner surface of the first side 32 of the cup 22 .
  • the inner face 96 includes a plurality of riblets 102 that extend inwardly, in the general direction of the extended passage 84 .
  • the riblets 102 can include lower surfaces 104 configured to engage the inclined surface 44 of the containment bottom 38 .
  • the three-dimensional gasket 26 is fabricated from a soft, pliable material such as polyvinylchloride (PVC) or neoprene.
  • the test strip 110 includes a detection end 112 and a non-detection end 113 .
  • the detection end 112 wicks fluid to a sensing zone 114 via capillary action through an absorbent material 116 .
  • the sensing zone 114 is configured with reagents that react and provide a visual indication when a certain constituent is present in the bodily fluid.
  • a width 118 of the test strip 110 is dimensioned to slidingly engage a corresponding one of the elongate channels 72 .
  • the test strip 110 is characterized as having increased thickness at both the detection and non-detection ends 112 and 113 due to the presence of the absorbent material 116 .
  • the sampling stem 28 is depicted in an embodiment of the invention.
  • the sampling stem 28 is characterized as having a proximal portion 132 and a distal portion 134 .
  • the proximal portion 132 can include a handle or knob 135 for handling and manipulation of the sampling stem 28 .
  • Certain aspects of the sampling stem 28 are depicted and described at U.S. Patent Application Publication No. 2012/0094303 to Engel et al., which is hereby incorporated by reference herein except for express definitions contained therein.
  • the proximal portion 132 includes structure that is complementary with structure on the cap portion 52 for securing the sampling stem 28 in a fixed position along the insertion axis 64 relative to the cap portion 52 .
  • the complementary structures comprise a female threaded structure 136 proximate the access port 54 of the cap portion 52 of the holder 24 and a male threaded portion 138 proximate the proximal portion 132 of the sampling stem 28 .
  • Other complementary structures could also be utilized, including a detent-and-groove snap fit structure a bayonet-style lock or a clasp.
  • the distal portion 134 of the sampling stem 28 includes a sampling swab 140 that is mounted to a collar 141 .
  • the collar 141 is comprised of a transparent material to enable ultraviolet activation of bonding agents that are placed between the sampling swab 140 and the collar 141 .
  • the distal portion 134 is configured for insertion through the through passage 58 and extended passage 84 .
  • the collar 141 is sized to provide a sliding seal between the collar 141 and the extended passage 84 .
  • the through passage 58 as well as the extended passage 84 is tapered (i.e., has a larger diameter at the proximal end than at the distal end) in order to guide the distal portion 134 without causing it to bind, but still affecting a seal as the collar 141 approaches its final axial location along the insertion axis 64 .
  • the testing assembly 20 is depicted in various states of assembly.
  • the three-dimensional gasket 26 is coupled to the bottom of the holder 24 and the test strips inserted into the respective elongate channels 72 so that the detection end extends into the extended channel.
  • the holder 24 and three-dimensional gasket 26 assembly, with test strips 110 loaded in the channels 72 is inserted into the cup 22 such that the three-dimensional gasket 26 is disposed between the holder 24 and the containment bottom 38 .
  • the cap portion 52 of the holder 24 is brought into contact with and joined to the continuous upper edge 36 of the cup 22 ( FIG. 12 ). Any joining or bonding method available to the artisan can be utilized to join the cap portion 52 to the cup 22 , including gluing, fusion or sonic welding, or a detent-and-groove snap fit engagement.
  • the extended passage 84 is in substantial alignment with the through passage 58 and is substantially concentric about the insertion axis 64 .
  • the pedestal portion 48 can extend partway into the extended passage 84 .
  • the perimeter 50 of the top face 49 of the pedestal portion 48 can be normal to the insertion axis 64 , and can also be concentric about the insertion axis 64 .
  • the three-dimensional gasket 26 can be compressed between the holder 24 and the inclined surface 44 of the containment bottom such that the lower face 92 of the perimeter structure 88 is in sealing contact with the inclined surface 44 of the containment bottom 38 .
  • the outer face 94 of the front portion 90 of the perimeter structure 88 can also be in sealing contact with the interior of the first side 32 of the cup 22 just above the junction line 46 .
  • a chamber 150 is defined, bounded by the diaphragm portion 86 , the perimeter structure 88 and the inclined surface 44 .
  • the chamber 150 is accessible via the extended passage 84 .
  • Each of the riblets 102 of the three-dimensional gasket 26 extend into the chamber 150 and are in substantial alignment with a corresponding one of the ribs 68 of the planar face 66 of the holder 24 to form a plurality of channel extensions 152 .
  • Engagement of the lower surfaces 104 of the riblets 102 with the inclined surface 44 creates a plurality of pockets 154 (partially depicted in FIG. 7 ) that are proximate the junction line 46 .
  • the detection end 112 of a given strip 110 accesses the channel extensions 152 and pockets 154 through slots 156 ( FIG. 6 ) formed proximate the front portion 90 of the perimeter structure 88 of the three-dimensional gasket 26 .
  • the sampling swab 140 of the sampling stem 28 is saturated with bodily fluid to be analyzed (e.g., saliva from a person being screened for drug use).
  • bodily fluid to be analyzed e.g., saliva from a person being screened for drug use.
  • the distal portion 134 of the sampling stem 28 is then inserted into the access port 54 and slid through the through passage 58 of the holder 24 and into the extended passage 84 of the three-dimensional gasket 26 .
  • the sampling swab 140 is thereby brought into contact with the pedestal portion 48 .
  • the sampling stem 28 is further pushed into the access port 54 until the male threaded portion 138 of the sampling stem 28 is engageable with the female threaded structure 136 of the access port 54 (or other complementary coupling structures become engageable).
  • the male threaded portion 138 is then threaded into the female threaded structure 136 until the proximal portion 132 of the sampling stem 28 is fully engaged within the access port 54 (e.g., by registration of the knob 135 against an upper periphery of the access port 54 ).
  • the threading action between the proximal portion 132 and the access port 54 also causes the sampling swab 140 to be further extended into the extended passage 84 of the three-dimensional gasket 26 , causing the sampling swab 140 to be compressed against the pedestal portion 48 (when present) or, more generally, against the containment bottom 38 .
  • the securing structure 51 secures the sampling swab 140 , thereby inhibiting the swab 140 from sliding laterally relative to the insertion axis 64 . By securing the sampling swab 140 , more efficient extraction of bodily fluid from the sampling swab 140 is attained during compression.
  • the compression acts to wring the bodily fluid out of the sampling swab 140 , which then flows over the pedestal portion 48 , down the inclined surface 44 and along saliva pathways 160 ( FIG. 12 ) to pool along the inner face 96 of the perimeter structure 88 proximate the lower most portion of the cavity 42 , i.e., into the pockets 154 located proximate the junction line 46 ).
  • the pockets 154 that are nearest the center of the three-dimensional gasket 26 i.e., more proximate the insertion axis 64 ) will tend to receive more fluid initially than the pockets 154 located near the extreme corners of the three-dimensional gasket 26 .
  • the riblets 102 can be dimensioned so that the pockets 154 accept only an amount needed to adequately activate the corresponding test strip 110 . Accordingly, as the bodily fluid flows into the nearest of the pockets 154 , these pockets will overflow and cascade over the riblets 102 as the pockets 154 become successively filled. Given an ample quantity of bodily fluid, all of the pockets 154 should receive sufficient bodily fluid for analysis.
  • the riblets 102 are sized and spaced so that a dozen pockets 154 can hold 1 ml of fluid and the sampling swab 140 sized to accept 20 ml of bodily fluid.
  • the depicted embodiments present twelve elongate channels 72 for housing twelve test strips 110 ; however, configurations having more or less channels 72 can also be implemented, depending on the quantity of fluid available for analysis. Typically, the number of elongate channels 72 ranges from 6 to 15.
  • the riblets 102 prevent more absorbent or faster absorbing test strips from drawing test fluid away from less absorbent or slower absorbing test strips, thus providing better and more predictable analysis results.
  • the insertion of the distal portion 134 of the sampling stem 28 into the extended passage 84 also acts to pressurize the chamber.
  • the three dimensional gasket 26 can be made of a soft, pliable material, so that the perimeter structure 88 provides a seal with the inclined surface 44 , and a seal is also affected between the collar 141 and the extended passage 84 as the collar 141 of the sampling stem 28 reaches its final position within the extended passage 84 .
  • the pliable material can also cause the diaphragm portion 86 to flex, thereby causing the air contained by the three-dimensional gasket 26 to become slightly pressurized.
  • the pressurization can still assist in the diffusion of the bodily fluid into the absorbent material 116 , thus augmenting the capillary action between the bodily fluid and the test strip 110 .

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Hydrology & Water Resources (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
US14/079,558 2012-11-13 2013-11-13 Screening device for analysis of bodily fluids Abandoned US20140134073A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US14/079,558 US20140134073A1 (en) 2012-11-13 2013-11-13 Screening device for analysis of bodily fluids
US14/834,534 US20160151779A1 (en) 2012-11-13 2015-08-25 Screening device for analysis of bodily fluids
US16/008,720 US10744507B2 (en) 2012-11-13 2018-06-14 Screening device for analysis of bodily fluids
US16/875,583 US20200276577A1 (en) 2012-11-13 2020-05-15 Screening device for analysis of bodily fluids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261725898P 2012-11-13 2012-11-13
US14/079,558 US20140134073A1 (en) 2012-11-13 2013-11-13 Screening device for analysis of bodily fluids

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/834,534 Continuation US20160151779A1 (en) 2012-11-13 2015-08-25 Screening device for analysis of bodily fluids

Publications (1)

Publication Number Publication Date
US20140134073A1 true US20140134073A1 (en) 2014-05-15

Family

ID=50681882

Family Applications (4)

Application Number Title Priority Date Filing Date
US14/079,558 Abandoned US20140134073A1 (en) 2012-11-13 2013-11-13 Screening device for analysis of bodily fluids
US14/834,534 Abandoned US20160151779A1 (en) 2012-11-13 2015-08-25 Screening device for analysis of bodily fluids
US16/008,720 Active 2034-04-08 US10744507B2 (en) 2012-11-13 2018-06-14 Screening device for analysis of bodily fluids
US16/875,583 Pending US20200276577A1 (en) 2012-11-13 2020-05-15 Screening device for analysis of bodily fluids

Family Applications After (3)

Application Number Title Priority Date Filing Date
US14/834,534 Abandoned US20160151779A1 (en) 2012-11-13 2015-08-25 Screening device for analysis of bodily fluids
US16/008,720 Active 2034-04-08 US10744507B2 (en) 2012-11-13 2018-06-14 Screening device for analysis of bodily fluids
US16/875,583 Pending US20200276577A1 (en) 2012-11-13 2020-05-15 Screening device for analysis of bodily fluids

Country Status (7)

Country Link
US (4) US20140134073A1 (hr)
EP (1) EP2920590B1 (hr)
AU (1) AU2013344883B2 (hr)
ES (1) ES2891329T3 (hr)
HR (1) HRP20211588T1 (hr)
PL (1) PL2920590T3 (hr)
WO (1) WO2014078451A1 (hr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160066895A1 (en) * 2013-04-30 2016-03-10 Microtri Limited Bodily Fluid Specimen Collection and Assay Device
CN105823652A (zh) * 2016-05-10 2016-08-03 华东师范大学 用于水体溶解态物质监测的被动采样装置及其使用方法
US9444193B1 (en) * 2015-04-07 2016-09-13 Tyco Electronics Corporation Electrical connector assembly and cable assembly having a conductive gasket to reduce electromagnetic leakage
USD775327S1 (en) * 2014-10-17 2016-12-27 Premier Biotech, Inc. Sampling device
USD790074S1 (en) * 2012-11-13 2017-06-20 Premier Biotech, Inc. Saliva test device
US9692170B2 (en) * 2015-05-12 2017-06-27 Samsung Electronics Co., Ltd Connection device, manufacturing method of the same, and electronic device including the same
US9759733B1 (en) * 2016-04-08 2017-09-12 Michael D. Callahan Mass produced, low cost, portable test kit for the detection and identification of narcotics
US10330603B1 (en) * 2016-04-08 2019-06-25 Michael D. Callahan Mass produced, low cost, portable test kit for the detection and identification of chemical and biological agents
CN113490547A (zh) * 2018-12-07 2021-10-08 阿尔缇玛基因组学公司 在样品处理和检测期间为受控环境实现屏障
WO2022020814A1 (en) * 2020-07-24 2022-01-27 The General Hospital Corporation On-site rapid quantification of tetrahydrocannabinol
US11376588B2 (en) * 2020-06-10 2022-07-05 Checkable Medical Incorporated In vitro diagnostic device
US11426722B2 (en) * 2019-06-05 2022-08-30 Phuong Nguyen Specimen tester including a separate initiator and method
WO2023071084A1 (zh) * 2021-10-30 2023-05-04 嘉兴康源科泰科技发展有限公司 一种柱推式采样检测一体化的快速检测结构及其应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2920590T3 (pl) * 2012-11-13 2021-12-20 Premier Biotech, Inc. Urządzenie przesiewowe do analizy śliny
CN110161268A (zh) * 2018-02-13 2019-08-23 杭州博拓生物科技股份有限公司 一种收集液体样本的装置
USD944409S1 (en) * 2018-07-26 2022-02-22 Healgen Scientific Limited Combined liquid sample collector and test device
US11724255B2 (en) 2019-02-14 2023-08-15 Marshall Venture Partners LLC Systems and methods for fluid sample collection and testing
US11730458B2 (en) 2019-02-14 2023-08-22 Marshall Venture Partners LLC Systems and methods for fluid sample collection and testing

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7029627B2 (en) * 2001-10-05 2006-04-18 Alley Kenneth A Apparatus for sampling, storing, preserving and testing a specimen
US20070196234A1 (en) * 2005-09-22 2007-08-23 Blane Huff Urine collection and drug testing cup
US7758815B2 (en) * 2004-08-03 2010-07-20 Hartselle R Lawrence Specimen collection, storage, transportation and assaying device

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE360179B (hr) 1972-01-31 1973-09-17 F Linder
DK0420960T3 (da) 1989-04-11 1994-11-21 Applied Research Systems Multianalyseprøveindretning
US5238652A (en) 1990-06-20 1993-08-24 Drug Screening Systems, Inc. Analytical test devices for competition assay for drugs of non-protein antigens using immunochromatographic techniques
BE1005090A5 (fr) * 1991-06-25 1993-04-13 Saliva Diagnostic Systems Inc Dispositif d'echantillonnage et systeme d'adequation d'echantillon.
US5976895A (en) 1996-03-11 1999-11-02 American Biomedica Corporation Device for the collection, testing and shipment of body fluid samples
US5869003A (en) 1998-04-15 1999-02-09 Nason; Frederic L. Self contained diagnostic test unit
US6379620B1 (en) 1998-11-16 2002-04-30 Barry M. Tydings Assaying device and method for in field urinalysis
US6488669B1 (en) * 1999-04-21 2002-12-03 Peter J. Sagona Collection cup for an automatic on-site drug testing system
KR100334393B1 (ko) 1999-06-30 2002-05-03 박종섭 반도체소자의 제조방법
US6616893B1 (en) 1999-11-12 2003-09-09 Tuan Pham Diagnostic testing kit for collection and testing of fluid samples with user configurable test strips and timer
US6464939B1 (en) 2000-07-06 2002-10-15 Varian, Inc. Saliva testing and confirmation device
US6669908B2 (en) 2001-07-25 2003-12-30 Applied Biotech, Inc. Urine test device
US7270959B2 (en) 2001-07-25 2007-09-18 Oakville Hong Kong Company Limited Specimen collection container
US7879293B2 (en) 2001-09-28 2011-02-01 Orasure Technologies, Inc. Sample collector and test device
US20040184954A1 (en) 2003-03-18 2004-09-23 Huiyan Guo Lateral flow immunoassay devices for testing saliva and other liquid samples and methods of use of same
CA2545215A1 (en) 2003-11-14 2005-06-02 Oakville Hong Kong Co., Limited Fluid sample analysis device with sealable sample storage reservoir
US7507373B2 (en) 2004-12-09 2009-03-24 American Bio Medica Corp. Assay device for the testing of fluid samples
US7741103B2 (en) 2006-03-31 2010-06-22 Guirguis Raouf A Integrated screening and confirmation device
US7879623B2 (en) 2006-03-31 2011-02-01 Guirguis Raouf A Integrated device for analyte, testing, confirmation, and donor identity verification
US8940527B2 (en) 2006-03-31 2015-01-27 Lamina Equities Corp. Integrated device for analyte testing, confirmation, and donor identity verification
US7695953B2 (en) * 2007-01-09 2010-04-13 American Bio Medica Corporation Apparatus for high-sensitivity body fluid testing device
US7927562B2 (en) 2007-12-13 2011-04-19 W.H.P.M. Inc. Collection and assay device for biological fluid
DE102009010563A1 (de) * 2009-02-16 2010-08-26 Matthias W. Engel Vorrichtung zum Nachweis von Analyten in Körperflüssigkeiten
JP5416227B2 (ja) * 2009-03-04 2014-02-12 ジョン ワン、 生物学的流体のための収集および検定デバイス
US9308064B2 (en) 2010-07-26 2016-04-12 Johnson & Johnson Consumer Inc. Devices and methods for collecting and analyzing fluid samples from the oral cavity
US9113850B2 (en) 2010-08-20 2015-08-25 Reflex Medical Corp. Saliva collection device
US20120282681A1 (en) 2011-05-05 2012-11-08 Teixeira Scott M Rapid Identification of Organisms in Bodily Fluids
US20130280698A1 (en) 2012-04-24 2013-10-24 Arizona Board Of Regents, Acting For And On Behalf Of Northern Arizona University Rapid multiplex lateral flow assay device
PL2920590T3 (pl) * 2012-11-13 2021-12-20 Premier Biotech, Inc. Urządzenie przesiewowe do analizy śliny

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7029627B2 (en) * 2001-10-05 2006-04-18 Alley Kenneth A Apparatus for sampling, storing, preserving and testing a specimen
US7758815B2 (en) * 2004-08-03 2010-07-20 Hartselle R Lawrence Specimen collection, storage, transportation and assaying device
US20070196234A1 (en) * 2005-09-22 2007-08-23 Blane Huff Urine collection and drug testing cup

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD790074S1 (en) * 2012-11-13 2017-06-20 Premier Biotech, Inc. Saliva test device
US20160066895A1 (en) * 2013-04-30 2016-03-10 Microtri Limited Bodily Fluid Specimen Collection and Assay Device
USD861158S1 (en) 2014-10-17 2019-09-24 Premier Biotech, Inc. Sampling device
USD775327S1 (en) * 2014-10-17 2016-12-27 Premier Biotech, Inc. Sampling device
US9444193B1 (en) * 2015-04-07 2016-09-13 Tyco Electronics Corporation Electrical connector assembly and cable assembly having a conductive gasket to reduce electromagnetic leakage
US10333245B2 (en) * 2015-05-12 2019-06-25 Samsung Electronics Co., Ltd Connection device, manufacturing method of the same, and electronic device including the same
US9692170B2 (en) * 2015-05-12 2017-06-27 Samsung Electronics Co., Ltd Connection device, manufacturing method of the same, and electronic device including the same
US10700470B2 (en) 2015-05-12 2020-06-30 Samsung Electronics Co., Ltd Connection device, manufacturing method of the same, and electronic device including the same
US9759733B1 (en) * 2016-04-08 2017-09-12 Michael D. Callahan Mass produced, low cost, portable test kit for the detection and identification of narcotics
US10330603B1 (en) * 2016-04-08 2019-06-25 Michael D. Callahan Mass produced, low cost, portable test kit for the detection and identification of chemical and biological agents
CN105823652A (zh) * 2016-05-10 2016-08-03 华东师范大学 用于水体溶解态物质监测的被动采样装置及其使用方法
CN113490547A (zh) * 2018-12-07 2021-10-08 阿尔缇玛基因组学公司 在样品处理和检测期间为受控环境实现屏障
US11426722B2 (en) * 2019-06-05 2022-08-30 Phuong Nguyen Specimen tester including a separate initiator and method
US11376588B2 (en) * 2020-06-10 2022-07-05 Checkable Medical Incorporated In vitro diagnostic device
WO2022020814A1 (en) * 2020-07-24 2022-01-27 The General Hospital Corporation On-site rapid quantification of tetrahydrocannabinol
WO2023071084A1 (zh) * 2021-10-30 2023-05-04 嘉兴康源科泰科技发展有限公司 一种柱推式采样检测一体化的快速检测结构及其应用

Also Published As

Publication number Publication date
US20200276577A1 (en) 2020-09-03
AU2013344883B2 (en) 2019-10-31
WO2014078451A1 (en) 2014-05-22
EP2920590A1 (en) 2015-09-23
EP2920590B1 (en) 2021-09-15
EP2920590A4 (en) 2016-07-13
ES2891329T3 (es) 2022-01-27
US10744507B2 (en) 2020-08-18
PL2920590T3 (pl) 2021-12-20
AU2013344883A1 (en) 2015-06-11
HRP20211588T1 (hr) 2022-01-07
US20160151779A1 (en) 2016-06-02
US20190015829A1 (en) 2019-01-17

Similar Documents

Publication Publication Date Title
US10744507B2 (en) Screening device for analysis of bodily fluids
US11358138B2 (en) Fluid sample collection device
EP3004866B1 (en) Multi-stage oral-fluid testing device
US11358139B2 (en) Pinch to open sample collection device
US11523805B2 (en) Methods for delivery of bodily fluids onto a fibrous substrate
WO2018188458A1 (zh) 一种样本收集器及样本收集检测的装置和方法
US9011770B2 (en) Device for detecting analytes in fluid samples
US7927562B2 (en) Collection and assay device for biological fluid
ES2622897T3 (es) Disposición para detección de hemólisis
US20200206743A1 (en) Simultaneous spot test and storage of blood samples
CN212514605U (zh) 一种检测装置
US9404910B2 (en) Body fluid testing apparatus with testing and storing functions
CN109069080B (zh) 利用毛细管技术的用于具有增大体积的血液收集器的系统和方法
WO2021027082A1 (zh) 一种样本收集及检测装置和方法
ES2529094T3 (es) Dispositivo de recogida y ensayo de fluido biológico
KR102483098B1 (ko) 검체 삽입형 진단키트
CN110462366B (zh) 用于在免疫测试之前浓缩生物样本的设备
CN110736842A (zh) 快速检测粪便乳铁蛋白一体化装置及检测方法
CN110967478A (zh) 一种检测液体样本中分析物的装置
SE2050749A1 (en) Collection device for bodily fluid samples

Legal Events

Date Code Title Description
STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION