US20120181225A1 - Medical Fluid Cassettes and Related Systems - Google Patents

Medical Fluid Cassettes and Related Systems Download PDF

Info

Publication number
US20120181225A1
US20120181225A1 US13/401,472 US201213401472A US2012181225A1 US 20120181225 A1 US20120181225 A1 US 20120181225A1 US 201213401472 A US201213401472 A US 201213401472A US 2012181225 A1 US2012181225 A1 US 2012181225A1
Authority
US
United States
Prior art keywords
cassette
dialysis
chamber
passage
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US13/401,472
Inventor
Manfred Weis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fresenius Medical Care Deutschland GmbH
Original Assignee
Fresenius Medical Care Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Medical Care Deutschland GmbH filed Critical Fresenius Medical Care Deutschland GmbH
Priority to US13/401,472 priority Critical patent/US20120181225A1/en
Assigned to FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH reassignment FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: WEIS, MANFRED
Publication of US20120181225A1 publication Critical patent/US20120181225A1/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/15Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit
    • A61M1/152Details related to the interface between cassette and machine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/15Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit
    • A61M1/152Details related to the interface between cassette and machine
    • A61M1/1524Details related to the interface between cassette and machine the interface providing means for actuating on functional elements of the cassette, e.g. plungers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/15Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit
    • A61M1/156Constructional details of the cassette, e.g. specific details on material or shape
    • A61M1/1563Details of incorporated filters
    • A61M1/15632Details of incorporated filters the filter being a dialyser
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601Control or regulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621Constructional aspects thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3401Cassettes therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3496Plasmapheresis; Leucopheresis; Lymphopheresis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36222Details related to the interface between cassette and machine
    • A61M1/362223Details related to the interface between cassette and machine the interface being evacuated interfaces to enhance contact
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36225Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit with blood pumping means or components thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362261Constructional details of cassettes, e.g. specific details on material or shape at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362263Details of incorporated filters
    • A61M1/362264Details of incorporated filters the filter being a blood filter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362265Details of valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/367Circuit parts not covered by the preceding subgroups of group A61M1/3621
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10Location thereof with respect to the patient's body
    • A61M60/104Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
    • A61M60/109Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
    • A61M60/113Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20Type thereof
    • A61M60/247Positive displacement blood pumps
    • A61M60/253Positive displacement blood pumps including a displacement member directly acting on the blood
    • A61M60/268Positive displacement blood pumps including a displacement member directly acting on the blood the displacement member being flexible, e.g. membranes, diaphragms or bladders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/30Medical purposes thereof other than the enhancement of the cardiac output
    • A61M60/36Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
    • A61M60/37Haemodialysis, haemofiltration or diafiltration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40Details relating to driving
    • A61M60/424Details relating to driving for positive displacement blood pumps
    • A61M60/427Details relating to driving for positive displacement blood pumps the force acting on the blood contacting member being hydraulic or pneumatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40Details relating to driving
    • A61M60/424Details relating to driving for positive displacement blood pumps
    • A61M60/427Details relating to driving for positive displacement blood pumps the force acting on the blood contacting member being hydraulic or pneumatic
    • A61M60/43Details relating to driving for positive displacement blood pumps the force acting on the blood contacting member being hydraulic or pneumatic using vacuum at the blood pump, e.g. to accelerate filling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80Constructional details other than related to driving
    • A61M60/845Constructional details other than related to driving of extracorporeal blood pumps
    • A61M60/847Constructional details other than related to driving of extracorporeal blood pumps arranged in a cassette
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36224Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit with sensing means or components thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/04Liquids
    • A61M2202/0413Blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/12General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/12General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A61M2205/121General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit interface between cassette and base
    • A61M2205/122General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit interface between cassette and base using evacuated interfaces to enhance contact
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/12General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A61M2205/125General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated filters
    • A61M2205/126General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated filters with incorporated membrane filters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/12General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A61M2205/128General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3331Pressure; Flow

Definitions

  • the invention relates to an apparatus for the treatment of a medical fluid comprising a fluid treatment machine and a cassette insertable therein substantially consisting of a rigid base body of the cassette with fitted chambers and passages and a foil covering them.
  • Cassettes are used in medical engineering, in particular to convey dialysis fluid, blood and the like.
  • a cassette can include a base body with fitted chambers and passages which is closed by a flexible foil to cover the passages and chambers.
  • the cassette can be inserted into a special receiving chamber, e.g., in a dialysis machine. This chamber can, for example, be opened via a pivotable door.
  • the cassette can be inserted into the chamber, with the flexible foil lying opposite a corresponding mating piece at the machine so that the cassette can be operated with the aid of actuators and sensors on the machine side.
  • Certain aspects of the invention relate to a generic apparatus comprising a fluid treatment machine and a cassette insertable therein such that a large flexibility for different applications is made possible while maintaining the fast and simple exchangeability.
  • actuators and sensors are arranged in a generic apparatus for the treatment of a medical fluid for the operation of the apparatus with an inserted cassette such that cassettes are insertable in different integration shapes.
  • cassettes of different complexity can be inserted into the fluid treatment machine in accordance with the desired application. It is therefore not necessary to provide different apparatus for different applications.
  • a cassette for a standard hemodialysis can thus be insertable here, for example.
  • the corresponding pump chambers, measuring sensors and further actuators, such as valves, etc. are provided at pre-determined locations in the fluid treatment machine.
  • Additional pumps, actuators, valves, etc. are provided in the fluid treatment machine which do not have to be actuated when the cassette is used for standard hemodialysis. They are, for example, only in use when a cassette is used for online hemodiafiltration or online hemofiltration.
  • Further passages, pump chambers, etc. are provided at corresponding positions in the corresponding cassettes which are associated with these actuators, pumps or valves.
  • a cassette for an acute dialysis treatment can be inserted in which in turn the pumps, actuators and valves provided on the side of the fluid treatment machine are associated with corresponding pumping chambers, passages, etc.
  • the associated control electronics can be selected depending on the inserted cassette for the control of the pumps, actuators, sensors, etc.
  • FIG. 1 a schematic plan view of a cassette for standard hemodialysis
  • FIG. 2 a schematic plan view of a cassette in accordance with the invention according to a further embodiment of the invention for use in online hemodiafiltration or online hemofiltration;
  • FIG. 3 a plan view of a cassette in accordance with a further embodiment of the present invention which can be used for acute treatment;
  • FIG. 4 a schematic plan view of a further aspect of the invention which substantially corresponds to that in accordance with FIG. 1 , but has an integrated dialyzer;
  • FIG. 5 a further aspect of the invention which substantially corresponds to that in accordance with FIG. 2 , but has an integrated dialyzer;
  • FIG. 6 a further embodiment of the invention which substantially corresponds to that in accordance with FIG. 3 , but has an integrated dialyzer;
  • FIG. 7 a three-dimensional representation of a fluid treatment machine as an embodiment of the apparatus in accordance with the invention without an inserted cassette;
  • FIG. 8 a representation corresponding to FIG. 7 , but with an inserted cassette
  • FIG. 9 a representation in accordance with FIG. 7 , but with a different embodiment variant of a cassette differing from the cassette shown in FIG. 8 ;
  • FIG. 10 a detail of a venting unit in the apparatus in accordance with the invention.
  • FIG. 11 a detailed view of a contour of a measuring chamber in a cassette in accordance with one of the aforesaid embodiment variants;
  • FIG. 12 a partially sectional representation of a pump chamber of the cassette in accordance with the present invention.
  • FIG. 13 a partially sectional representation through a passage of the cassette in accordance with an embodiment variant of the invention.
  • FIG. 14 a cross-sectional view of a valve
  • FIG. 15 a diagrammatic view of the valve of FIG. 14 in use in a disposable cartridge
  • FIG. 16 a perspective view of a fluid guide body having an open main passage and a secondary passage opening therein in accordance with an embodiment of the invention in a sectional representation;
  • FIG. 17 a perspective view of a base body of the cassette of FIG. 1 in a partial section, wherein a covering film is pressed onto the fluid guide body by a valve actuator and closes the secondary passage;
  • FIG. 18 a perspective view similar to FIG. 17 , wherein the secondary passage is represented in its open position;
  • FIG. 19 a schematic, 3D representation of a section of an elastic matt according to an embodiment of the present invention.
  • FIG. 20 a section along the section line A-A′ in FIG. 19 ;
  • FIG. 21 a section along the section line B-B′ in FIG. 19 ;
  • FIG. 22 a section along the section line C-C′ in FIG. 19 .
  • FIG. 1 a cassette 10 in accordance with an embodiment of the present invention is shown which can be used for standard hemodialysis.
  • the surface of the cassette 10 is divided into a hatched region B (two partial areas) and a non-hatched region A.
  • Both the surface of the cassette 10 and the surface of an associated machine block 108 (shown in FIG. 7 ) are divided into the covering surface regions A and B.
  • Components of actuators or sensors to be coupled, which are common to all cassettes as basic variants (e.g., all the cassettes for standard hemodialysis) are accommodated in the surface region A (not hatched in FIG.
  • FIG. 2 illustrates a cassette that includes operable components in a region corresponding to a surface region B.
  • the cassette consists of a base body 12 of a cassette which consists of polypropylene in the embodiment shown here.
  • a cover foil 14 (shown in FIGS. 10 , 12 , 13 , 17 , and 18 ) consisting, for example, of a polyolefin elastomer mixture, is applied to the base body 12 of the cassette 10 .
  • the passages and recesses, which will be looked at in more detail later, are covered by this cover foil 14 .
  • An arterial injection septum 16 is provided in the arterial line 18 to the dialyzer and a venous injection septum 20 is provided in the venous line 22 to the dialyzer.
  • the dialyzer itself and the corresponding tube connection are not shown in any more detail in the embodiment shown here.
  • Reference number 24 designates the blood inlet from the patient and reference number 26 designates the blood outlet to the patient.
  • the respective tubes which likewise consist of a polyolefin elastomer mixture, are also not shown here for reasons of simplification.
  • Passages 28 are recessed in the base body 12 of the cassette 10 . They are acted on by a row of valves 30 .
  • valves 30 have a valve body with a pressure passage and a sealing cap which cooperates with the valve body such that it closes the end of the pressure passage on the valve body side with respect to the environment, with a pressure space being able to be built up between the pressure passage and the sealing cap so that the sealing cap has a deformable sealing region for entry into the fluid passage in order to close this as required.
  • FIG. 14 shows one of the valves 30 in a sectional view, which is rotation-symmetric about a vertical axis.
  • the valve 30 includes a valve body 112 with a pressure channel 114 , which ends in a pressure chamber 116 .
  • a sealing cap 118 with a deformable area 120 which bounds the pressure chamber 116 , is placed over the valve body 112 .
  • the pressure channel 114 of the valve body 112 is elongated, so that it can be inserted, for example, through the body or a wall of a counterpart of the disposable cassette 10 on the device side (i.e., through the machine block 108 ) and can be screwed down with a lock nut 122 .
  • a thread is provided on the outer wall of the portion of the valve body 112 that forms the pressure channel 114 to allow the lock nut 122 to secure the valve body 112 to the machine block 108 .
  • the valve body 112 has sealing surfaces 124 for sealing the valve body 112 in the machine block 108 .
  • the sealing cap 118 includes protruding bulges 126 , which surround the valve body 112 in such a way that they lie adjacent to the sealing surfaces 124 and are pressed when the valve 30 is assembled.
  • the upper area of the valve 30 is the area on the fluid passage side (i.e., the side nearest the cassette 10 ).
  • a projection 130 of the sealing cap 118 lies on the end of the valve body 112 , on the fluid passage side.
  • a shoulder 128 of the sealing cap 118 is provided to ensure that that the sealing cap 118 fits into its associated fluid passage in the cassette 10 .
  • the valve 30 is shown diagramatically in use in FIG. 15 .
  • the base body 12 of the disposable cassette 10 in which liquid passages 28 are formed is shown in diagrammatic representation.
  • the corresponding counterpart of the disposable cartridge body on the device side i.e., the machine block 108 ) is shown pressed against the cassette 10 .
  • the valve 30 is inserted into a suitably shaped housing (e.g., recess) 138 of the machine block 108 and screwed down with the lock nut 122 .
  • the shoulder 128 lies adjacent to the edges of the liquid passage 28 .
  • Reference number 142 indicates the direction in which the pressure is applied in order to close the valve 30 .
  • the housing 138 in the machine block 108 is rotation-symmetric about the pressure channel 114 of the valve 30 , and the liquid passage 28 extends perpendicular to the plane of the figure.
  • a cut-out for accommodating the shoulder 128 can be provided either in the base body 12 of the cassette 10 or in the machine block 108 . It is also possible for the shoulder 128 to be accommodated in a suitable opening in a cover mat located between the cassette 10 and the machine block 108 .
  • FIG. 15 does not show the cover foil 14 of the cassette 10 , which closes off the fluid passage 28 against the surroundings.
  • the cover foil 14 (shown in FIGS. 10 , 12 , 13 , 17 , and 18 ) can be fixed on the side of the base body 12 of the cassette 10 that is pressed against the machine block 108 .
  • the cover foil 14 is sufficiently flexible so that it can follow the deformation of the deformable area 120 of the sealing cap 118 of the valve 130 .
  • valve body 112 is inserted through the housing 138 of the machine block 108 , so that the pressure channel 114 extends through the machine block 108 .
  • the lock nut 122 is tightened up so that the protruding bulges 126 create a seal between the valve body 112 and the machine block 108 .
  • the machine block 108 with the valve 30 is pressed against the cassette 10 , whereby the shoulders 128 of the sealing cap 118 fit tightly with the edges of the liquid passage 28 .
  • several valves 30 can be simultaneously fitted into their corresponding liquid passages 28 at the desired points.
  • the dialysis liquid flows through the fluid passage 28 when the valve 30 is in the opened state. If excess pressure is applied via the pressure channel 114 in the direction of the arrow 142 , the deformable area 120 of the sealing cap 118 is deformed into the liquid passage 28 until the valve 30 is finally closed. The loading on the sealing cap 118 is reduced by the projection 130 of the sealing cap 118 , without the movement of the deformable area 120 being significantly impaired.
  • the cover foil 14 of the cassette 10 is deformed together with the sealing cap 118 into the liquid passage 28 .
  • the pressure channel 114 is vented and the deformable area 120 of the sealing cap 118 is relaxed.
  • the deformable area 120 is placed against the convex curvature of the pressure chamber 116 and correspondingly increases the cross-section of the fluid passage 28 .
  • the flow rate through the fluid passage 28 can be controlled.
  • valve 30 can be removed or replaced simply by loosening lock nut 122 , e.g., for maintenance or in the event of malfunction.
  • the sealing cap 118 is a simple low-cost shaped part, which on account of its closed design can easily be cleaned and thus satisfies the hygiene requirements in dialysis, but which can also easily be replaced when necessary.
  • the valve 30 fits into the fluid passage 28 very well by pressing the shoulder 128 with the edge of the fluid passage 28 .
  • the deformable area 120 of the sealing cap 118 guarantees that only small forces are required to block the fluid passage 28 .
  • valves 30 and their operation with disposable cartridges are discussed in DE 100 46 651, which is incorporated by reference herein.
  • an arterial measuring chamber 32 and a venous measuring chamber 34 are furthermore recessed in the base body 12 of the cassette 10 .
  • the basic design of these measuring chambers is shown in FIG. 11 .
  • the flow direction of the fluid, i.e., of the blood through the chambers 32 , 34 is indicated by the arrows.
  • the measuring chambers 32 and 34 have a widened passage section to be able to receive the sensors 36 .
  • the contour of the measuring chambers 32 , 34 corresponds to a diffuser nozzle geometry such as is shown in FIG. 11 .
  • a diffuser 38 which runs out in a nozzle 40 , is arranged in the region of the inflow region of the fluid.
  • the widened cross-section in the diffuser 38 is relatively rapid in comparison to the narrowed cross-section in the nozzle 40 .
  • the sensors 36 which are made in the form of multi-functional sensors, are arranged in the region of the arterial or venous measuring chamber 32 , 34 .
  • each of the sensors 36 for measuring selected parameters of the medical fluid passing in the arterial and venous measuring chambers 32 , 34 is disposed on a measurement plate that has a peripheral seal along its outer edge and that is in contact with the flexible membrane (i.e., the foil 14 ).
  • the measurement plate has an inlet that leads to the foil 14 so that a vacuum can be established between the measurement plate and the foil 14 .
  • the flexible membrane i.e., the foil 14
  • the medical fluids are separated from the sensors on the measurement plate only by the foil 14 .
  • the foil 14 can be brought in close contact with the underside of the measurement plate by applying a vacuum, so that very close contact can be established between the sensors and the medical fluid in the measurement chamber.
  • the contact surface of at least one of the sensors is preferably flush with the underside of the measurement plate, so that it is possible to establish direct measurement contact between the respective sensor and the flexible membrane.
  • Each respective sensor is preferably mounted in a recess in the measurement plate, with the measurement surface of the sensor being in flush contact with the underside of the measurement plate.
  • the sensors are preferably securely glued to the measurement plate.
  • a pressure sensor and a temperature sensor may be used.
  • Pressure sensors have become available formed on individual semiconductor chips due to advances in integration of Microsystems, so that the chips carrying the sensor are only a few square millimeters in size. Because the sensor surface can be brought in direct contact with the foil 14 , it is possible to measure both positive and negative pressures. As a result, the thermal energy balance and the venous pressure in a dialysis machine can be measured with the pressure sensor and the temperature sensor.
  • the seal of the measurement plate is made of a rubber ring which is inserted into a groove in the measurement plate and projects slightly above the edge of the measurement plate. As soon as a vacuum is established between the membrane (i.e., the foil 14 ) and the measurement plate, the foil 14 is pressed tightly against the underside of the measurement plate by the ambient air pressure, and the seal guarantees that no additional air can flow into the area between the measurement plate and the foil 14 .
  • the measurement plate can be made of a metal disk into which the respective sensors are inserted.
  • the metal disk is kept at a constant temperature by, for example, Peltier elements. This design permits a more accurate temperature measurement of the medical fluid.
  • a vacuum is first applied to the inlet so that the film (i.e., the foil 14 ) is placed in close contact with the sensors. Then, the sensors are activated by a control unit (not shown), so that the respective measurements can begin.
  • an arterial port 42 and a heparin port 44 are provided at the cassette, which are each connected via corresponding passages to the passage carrying the arterial blood in each case via phantom valves 46 .
  • the phantom valves 46 are used in the cassette 10 in accordance with the invention instead of conventional open T-branches. In these phantom valves, the passage wall is not interrupted from the aspect of the main blood flow.
  • Reference number 48 designates a venous port which likewise opens into a blood-carrying passage 28 , here in the venous part of the blood-carrying passages, via a phantom valve 46 .
  • the fluid guide body (i.e., the base body 12 ) of the cassette 10 has a main fluid passage 28 , which is integrally worked into the base body 12 and is closed by a covering film (i.e., the foil 14 ), which is not shown in FIG. 16 .
  • the fluid guide body (i.e., the base body 12 ) further has a secondary passage 144 that leads away from the rear side of the base body 12 , which is remote from the open side of the main passage 28 , onto the opposite front side of the base body 12 and opens there into the main passage 28 .
  • the secondary passage 144 passes through a base 146 of the main passage 28 .
  • the secondary passage 144 extends into the main passage 28 in the form of a volcano-like funnel 148 whose height corresponds to the depth of the main passage 28 so that an orifice 150 of the secondary passage 144 is arranged vertically coincident with the rims of the main passage 28 .
  • the secondary passage 144 is positioned symmetrically in the center of the main passage 28 and extends perpendicularly to the longitudinal direction of the main passage 28 .
  • the planar designed orifice 150 is in the plane which is set up by the rims of the main passage 28 .
  • the funnel 148 has a streamlined cross-section.
  • the outside of the wall of the secondary passage 144 in the main passage 28 is formed in streamlined manner, with the longitudinal axis of the streamlined shape corresponding to the longitudinal axis of the main passage 28 . Vortexes, turbulences and an increased flow resistance are thereby avoided at the secondary passage 144 .
  • the medical fluid flowing through the main passage 28 can flow past the secondary passage 144 in laminar fashion.
  • the contours of the main passage 28 are also formed extending in streamlined fashion around the secondary passage 144 .
  • the side walls of the main passage 28 opposite the funnel 148 bulge in streamlined fashion around the funnel 148 so that the fluid flow forking around the funnel 148 finds approximately the same flow cross-section and can flow past the funnel 148 without speed changes.
  • the covering film i.e., the foil 14
  • the foil 14 can be welded to the base body 12 along the rims of the main passage 28 .
  • the sealing can, however, also be effected by pressing the foil 14 along the rims of the main passage 28 by a valve plunger 152 .
  • the valve plunger 152 has a continuous, planar plunger surface 154 that is formed by an elastic (e.g., elastomer) machine membrane. Due to the vertically coincident arrangement of the orifice 150 with the rims of the main passage 28 , the secondary passage 144 can be closed without stretching of the foil 14 , if the foil 14 is pressed onto the base body 12 .
  • the orifice 150 is formed for this purpose as a planar valve seat 156 , which is in the plane set up by the rims of the main passage 28 and forms the front end of the funnel 148 .
  • FIG. 17 shows the closed state of the secondary passage 144 .
  • the plunger surface 154 is pressed onto the base body 12 . Additional pressure can be applied by an actuating part 158 in the region of the orifice 150 of the secondary passage 144 in order to achieve a reliable sealing of the secondary passage 144 .
  • the actuating part 158 which is connected to the plunger surface 154 in the region of the secondary passage orifice 150 , is moved away from the base body 12 .
  • the plunger surface 154 is thereby raised from the orifice 150 of the secondary passage 144 in the region thereof.
  • FIG. 18 shows, the plunger surface 154 thereby deforms, which is allowed by the design of the same as an elastic membrane.
  • the foil 14 also lifts off the orifice 150 of the secondary passage 144 due to the raising of the plunger surface 154 .
  • the pressure of the flow in the main passage 28 presses the foil 14 away from the orifice 150 .
  • this can also be supported actively by the interposition of a vacuum between the plunger surface 154 and the foil 14 , which is helpful in particular when a sample should be sucked from the fluid flow in the main passage 28 through the secondary passage 144 .
  • the foil 14 stretches elastically.
  • the deformation is here very low, however. It is in particular not plastic so that a formation of creases in the subsequent re-closing of the orifice 150 is prevented.
  • the secondary passage 144 is in flow communication with the main passage 28 in the raised state of the foil 14 .
  • reference numbers 50 designate two pump chambers which serve to pump the blood.
  • the design of the pump chambers 50 is shown in detail in FIG. 12 .
  • the pump chambers 50 which are activated via membrane pumps provided at the machine side (i.e., in the machine block 108 ), have substantially tangential inlets and outlets for a uniform throughflow of the total chamber, as shown in FIG. 1 .
  • the shape of the pump chambers 50 is pre-determined by the correspondingly shaped base body 12 of the cassette 10 and can be approximately described as a spherical section. At the periphery, the base body 12 of the cassette 10 has a raised edge 52 around the pumping chambers 50 which serves as a stop bead.
  • FIG. 12 the base body 12 of the cassette 10 has a raised edge 52 around the pumping chambers 50 which serves as a stop bead.
  • the peripheral edge of the spherical section is set somewhat lower so that in the pressing-out phase, that is in the phase in which the cover foil 14 is moved toward the base body 12 of the cassette 10 , a flushing edge or flushing passage 54 is formed.
  • the flushing edge or flushing passage 54 is advantageously made in that the spherical pump surface at the machine side (i.e., the spherical pump surface in the machine block 108 ), which is not shown in FIG. 12 , has a smaller radius than the radius of the pump chamber 50 at the cassette side.
  • the radius difference ⁇ r is shown in FIG. 12 .
  • a wide flushing edge or flushing passage 54 is hereby formed.
  • This flushing edge or flushing passage 54 is an annular space for the pumped blood in the extreme pressing-out position.
  • This free annular space avoids blood damage by being trapped between the foil surface and the injection molded surface (i.e., the base body 12 ) at the end of the pressing-out phase and, on the other hand, blood damage due to high flow speeds and shearing strains which would result at the start of the start-up phase if no free annular space were provided.
  • a venting chamber 56 is formed which is shown again in FIG. 10 in a sectional representation.
  • a venting membrane 58 is arranged in this venting chamber via which correspondingly collected air can be separated since it is made as a partially permeable membrane which preferably has hydrophobic or oleophobic properties. Expanded or sintered polytetrafluoroethylene can preferably be used as the venting membrane.
  • a venting stub 60 is arranged above the venting membrane 58 and its cooperation with the fluid treatment machine (not shown in more detail here) will be described later.
  • Bubbles are trapped in the venting chamber 56 by a slowing down of the blood flow.
  • a rotation flow is generated for effective air separation with minimum area requirements on the cassette 10 .
  • the generation of the final rotation flow is only created in the operating state of the cassette 10 in the fluid treatment machine 100 .
  • the cover foil 14 of the cassette 10 is pulled into the fluid treatment machine 100 by a corresponding vacuum coupling system of which only one vacuum suction passage 102 is shown in FIG. 10 .
  • An almost circular cross-section of the venting chamber 56 is thereby formed.
  • the rotation flow of the blood is supported in that the passage opening into the venting chamber 56 also runs—together with its cover foil 14 —slightly into the machine side so that an almost tangential inflow within the chamber is achieved.
  • An effective suction can take place at the machine side at the venting stub 60 .
  • a low filling volume results overall here in the venting chamber 56 as a result of the construction.
  • the basic design of the passages 28 can be explained with reference to FIG. 13 .
  • All passages 28 and also chambers 50 have an edge bead 52 which accompanies the passages and faces the cover foil 14 .
  • the foil 14 is pressed onto the edge bead 52 such that all passages 28 are sealed against the environment.
  • webs 62 are formed which accompany the passages and via which the rear pressing force is guided to the edge beads 52 in order thus to achieve a uniform linear distribution of force.
  • the base body 12 of the cassette 10 is welded to the cover foil 14 at the outer edge 64 .
  • the cassette 10 has a recessed centering fork 66 as a positioning aid which receives a centering pin on the machine side on insertion. Stop noses 68 are furthermore molded on which contact against corresponding machine surfaces on insertion. The cassette 10 is thereby guided in height and angle. When pressing the cassette 10 into the fluid treatment machine 100 , a latching with the fluid treatment machine takes place at a snap element not shown in more detail here such that the cassette 10 is fixed in an aligned manner.
  • the cassette 10 has a molded handle 70 at the side disposed opposite the centering fork 66 for simplified handling.
  • the arterial injection septum 16 or the venous injection septum 20 are made in the embodiment shown here, in contrast to a conventional injection position, such that their base body is formed by the base body 12 of the cassette itself so that here only the elastic septum is fixed by a snap ring (not shown in detail here).
  • the septum consists of an elastomer in the embodiment shown here.
  • FIG. 4 shows a modified embodiment of the cassette in accordance with FIG. 1 .
  • This cassette 10 shown in FIG. 4 also serves standard hemodialysis and largely shows an identical design to the cassette 10 in accordance with FIG. 1 . To this extent, a detailed description of the already described components of the cassette 10 is superfluous.
  • a dialyzer 72 is integrated in the side of the cassette 10 , with the lines 18 and 22 to the dialyzer opening directly into the dialyzer.
  • the dialysate connections at the dialyzer which can have a conventional design, are designated by 74 and 76 .
  • FIG. 2 is designed as an online hemodiafiltration cassette. It becomes clear from the arrangement of the different elements that the base body 12 of the cassette 10 starts from that base body of a cassette such as has already been described in FIG. 1 with reference to the embodiment for standard hemodialysis. All elements which are known from this configuration can be found in the same manner in the embodiment variant in accordance with FIG. 2 for online hemodiafiltration. To this extent, they will not be additionally explained again. However, those parts will be explained which are necessary for the operation of the hemodiafiltration cassette. This includes the substituate connector 80 via which the substituate fluid is fed into the passages 28 .
  • Substituate passage valves 82 are provided at the passages and the passages 28 can be closed at the appropriate positions via these valves 82 .
  • the substituate fluid is guided into two parallel pump chambers 84 , which form substituate pump chambers, via the passages 28 .
  • the substituate pump chambers 84 substantially correspond to the pump chambers for the blood 50 as they have previously already been described in detail.
  • the substituate fluid is guided through a substituate tunnel 86 which is disposed on the opposite side of the base body 12 of the cassette 10 .
  • the substituate tunnel 26 is suitably closed at the rear side, e.g., by a welded foil.
  • the substituate fluid 86 can be led into the passage 28 carrying the blood via a port for pre-dilution 88 or via a port for post-dilution 90 .
  • the ports are again made as phantom valves of the type described above.
  • the substituate region substantially formed by the substituate pump chambers 84 is surrounded by a substituate weld rim 92 to which the cover foil 14 is sealingly welded so that this region of the cassette 10 processing substituate is separated from the blood-carrying region.
  • FIG. 5 a modification of the embodiment variant in accordance with FIG. 2 is shown.
  • a dialyzer 72 is integrated directly into the cassette 10 .
  • a cassette 10 for acute treatment is shown as a further integrated embodiment of the cassette. It is designed identically to the embodiment variant in accordance with FIG. 1 in the region of the blood treatment part. With respect to the substituate part, it partly corresponds to the embodiment in accordance with FIG. 2 , with here only one substituate pump chamber 84 being provided which is fed by the substituate fluid led in via the substituate connector 80 and the passage 28 . In a similar manner as to the embodiment variant in accordance with FIG. 2 , substituate passage valves 82 are provided before and after the substituate pump chamber 84 .
  • the further pump chamber which is designated by 94 in the present embodiment variant for acute treatment, is connected to a filtrate outlet 96 via a passage 28 and opens into a filtrate connection 98 which is connected to the dialyzer not shown in any more detail here.
  • FIG. 6 a modified embodiment variant of the cassette 10 in accordance with FIG. 3 is shown.
  • a dialyzer 72 is in turn integrated instead of the handle, with here a connection 99 being provided between the dialyzer 72 and the passage 28 which carries the filtrate and which leads to the filtrate pump chamber 94 .
  • FIG. 7 an embodiment of the fluid treatment machine 100 is shown without an inserted cassette 10 .
  • This fluid treatment machine 100 is designed such that all aforesaid cassettes can be inserted, with a basic extracorporeal blood circuit, i.e. a standard dialysis using an external dialyzer, being carried out by a corresponding program selection, for example on insertion of the cassette in accordance with the embodiment variant in accordance with FIG. 1 .
  • a cassette 10 in accordance with the embodiment of FIG. 2 is used, online hemodiafiltration or an online hemofiltration variant is, for example realized by use of the components required for this purpose with, optionally, automatic connections (not shown) to the fluid circuit of the basic unit.
  • the fluid treatment machine 100 substantially consists of a frame 104 which surrounds and/or includes or receives the most important components.
  • a door 106 is fitted to the frame 104 , on the one hand, and the machine block 108 is guided in the frame, on the other hand. All forces occurring between the door 106 and the interior of the unit are absorbed by means of the frame 104 , namely the door hinge, door latch, pressing actuator system and the rear wall.
  • the frame 104 furthermore contains the door latch 110 .
  • the cassette 10 is received between the door 106 and the machine block 108 , as shown in the FIGS. 8 and 9 , and is sealed by pressing.
  • Sensor system elements are included in the cassette region of the machine and they detect whether a cassette is correctly positioned in the fluid treatment machine. These, or further sensor system elements, can be designed such that they are suitable for recognizing the cassette type (e.g. with the aid of a barcode on the cassette).
  • This machine block 108 establishes the most important interface to the cassette 10 .
  • the cassette surface is coupled to the unit here and the sealing of the cassette 10 , and thus the fixing of the flow paths, takes place by this.
  • the machine block 108 is guided movably in the frame and fixes the cassette 10 , as already described above, until the door 106 is closed.
  • Hydraulic piston pumps are contained in the fluid treatment machine which are not shown in detail in FIGS. 7 , 8 and 9 here. They are, on the one hand, blood pumps or optional substituate feed pumps or ultrafiltrate pumps. They are hydraulically connected to the pump chambers (i.e., the blood pump chambers) C, D, and, in some cases, they are hydraulically connected to the optional filtrate pump chambers and/or the optional substituate pump chambers E, F. Furthermore, compressors for the generation of the required pneumatic pressure (overpressure or vacuum) not shown in more detail here are contained in the fluid treatment machine 100 . The fluid treatment machine 100 furthermore has—in a manner not shown in more detail—a pneumatic buffer container for the compensation of pressure fluctuations, a main electronics box, a heparin injection pump and a blood pressure monitor module.
  • a pressing actuator system on the rear wall of the frame 104 likewise not shown in more detail, must be emphasized here.
  • An inflatable air cushion is integrated here which can move the whole machine block 108 , which is movably supported in the frame 104 , and press it against the closed door 106 .
  • an air distributor plate is provided at the machine block 108 which contains main connections for the pneumatics and which guides compressed air and vacuum to the valves and actuators via passages integrated there without any substantial tubing, with them simultaneously terminating the machine block with respect to the interior of the fluid treatment machine 100 .
  • Optional modules can be provided in the fluid treatment machine 100 for the carrying out of the online hemodiafiltration.
  • an online feed port for the automatic coupling of a cassette 10 to a dialysate circuit or an online flushing port for the return of flushing solution can be contained here.
  • the door 106 must be open for the insertion of the cassette 10 .
  • the cassette 10 is inserted and, after positioning of the centering fork 66 , is fixed to the surface of the machine block by means of a snap hook.
  • the side of the machine block 108 facing the cassette 10 is lined with a soft elastomer mat 160 (shown in FIG. 19 ), which seals the cassette 10 after pressing has taken place.
  • the elastic matt 160 is arranged between the fluid treatment machine (i.e., the machine block 108 ), of which no detail is shown here, and the cassette 10 .
  • the fluid treatment machine i.e., the machine block 108
  • matt channels 162 and connection channels 164 are formed on the so-called machine side, namely on the surface which, when assembled, faces the fluid treatment machine 100 .
  • a recess 166 is arranged in the elastic matt 160 , into which in the assembled condition a machine-mounted valve, for example, engages and establishes a seal all around. It is easy to see that this machine-mounted valve interrupts the respective matt channel 162 which happens to join the recess 166 .
  • connection channel 164 which connects the two interrupted branches of the matt channel 162 and connects them in turn with a further, parallel matt channel 162 .
  • the structure shown here is, of course, only an example and can be changed in any way. While the channel structures are provided on the machine side of the elastic matt 160 , the disposable side, namely the side facing the cassette, is executed as a smooth, i.e., flat surface.
  • FIG. 20 The section A-A′ as per FIG. 19 is shown in FIG. 20 where a matt channel 162 becomes visible which, with the elastic matt 160 used here having a thickness of 4 mm, has a depth of 3 mm and a width of 2 mm.
  • a slit 168 is placed which takes on a type of valve function. When a vacuum is applied, the two areas of the elastic matt 160 adjacent to the slit 168 will open and enable the extraction of air gas.
  • connection channel 164 is shown in the sectional view of C-C′, where said channel is narrower and not as deep as the matt channel 162 , which can be seen clearly in this view.
  • both the width of the connection channel 164 and the depth are one millimeter each.
  • the opening effect of the slits can be utilized by applying a vacuum.
  • the elastic matt 160 Since the elastic matt 160 is exchangeable, it can be replaced easily after contamination or a fault. It is especially advantageous that no structured shapes are required for the fixed components on the machine. On the side of the elastic matt 160 facing the machine, open structures can be formed so that no sub-surface tunnels or other closed structures are required. On the other hand, the side of the elastic matt 160 facing the cassette is largely formed as a smooth, closed surface which can be cleaned easily for example.
  • pressing takes place by inflating the aforesaid air cushion.
  • the pressing is cancelled again by letting out the air in the air cushion before opening the door 106 .
  • the air cushion has approximately the size of the machine block 108 or of the cassette 10 .
  • the traction between the door 106 , the frame 104 and the rear wall takes place by the door hinge, the latch 110 and connection bolts, not shown in any more detail here, between the frame and the rear wall.
  • this signal can be linked to information on the door position which can be picked up by a separate sensor.
  • the latching bolt not shown in any more detail here can have a latch connection.
  • This latch connection consists of a spring-loaded latch ball on the door side which latches into a corresponding arch of the latch bolt and can hold the door in the corresponding position.
  • An introduction slope is provided for the simplified latching. To open the door from the latch position, the latch ball present here is drawn back by means of a mechanical system.
  • the blood circuit substantially consists of at least one hydraulically controlled membrane pump having two independent pump chambers C and D which can be used as a highly precise flow pump or as a volumetric metering unit, a row of valves M, O and clamps N for the control of the flow path, a highly integrated sensor system G, H required for monitoring and control, an active air extractor, i.e., an air separation chamber I with a connected cassette venting A, of the blood circuit (air-free circuit) and a door 106 to fix the cassette 10 .
  • an active air extractor i.e., an air separation chamber I with a connected cassette venting A
  • the fluid treatment machine 100 respectively comprises a pneumatic system for the overpressure and a pneumatic system for the underpressure.
  • the underpressure serves, for example, to apply an underpressure between the foil 14 of the cassette 10 and the unit side to prevent a passage restriction on the plastic deformation of the foil, to raise the foil at feed positions and thus to be able to keep the access free, to avoid air compliance in the pump devices and to be able to ensure an air-free coupling between the sensor and the foil at specific sensor positions.
  • the air suction requires openings in the unit side and a suction unit, i.e., a vacuum pump, connected to it, wherein the vacuum distribution should be ensured as uniformly and as reliably as possible over the whole surface. In the idling state, the openings should be at least largely closed to permit a good cleaning here. In operation, however, a problem-free air suction should be possible. This problem is solved by the elastomer mat of the type described above.
  • the cassette 10 In the cassette 10 , no passage seals are contained except for the edge region and some safety weld connections. The sealing of all flow paths and passages must therefore take place by pressing.
  • the cassette has sealing beads 52 on the passage rims which have already been described above and which are sealable on the pressing of the disposables between the machine block 108 and the door 106 by pressing into the elastic mat.
  • the air distributor plate not shown in any more detail here is located on the rear side of the machine block 108 and is connected to the, for example, two membrane pumps of the pneumatic system, namely the overpressure pump and the underpressure pump.
  • the air distributor plate is sealed with respect to the rear side of the machine block by a sealing mat and permits the compressed air and vacuum feed via integrated passage structures so that every valve does not need its own tubing.
  • a plurality of circuits are present on the air distributor plate, namely a vacuum circuit, a compressed air circuit which is directly connected to the compressor for the supply of components which always need compressed air, a compressed air circuit for the protection of sensitive components which may only be charged with compressed air under certain states, with it also being separable from the compressor by an on/off valve and an exhaust circuit.
  • the electrical supply can also be collected via a small control board. Since a plurality of valves are only needed with specific options, a modular retrofitting capability must be ensured.
  • the sensor system and the pump connections are guided through the plate through apertures and cut-outs.
  • Sensors which are collected in integrated sensor modules in the present fluid treatment machine 100 are required for the monitoring and control of the extracorporeal blood circuit.
  • Two respective modules work together as a pair.
  • One module is accommodated in the door 106 and the counter-piece in the machine block 108 .
  • Both the arterial branch should be monitored by the arterial measuring chamber G and the venous branch by the venous measuring chamber H.
  • the integrated measurement sensor system is described in detail in the German patent applications DE 198 37 667 A and DE 101 43 137 of the same patent applicant.
  • the sensors together have the following properties or provide the following possibilities:
  • a multi-sensor module is usually fitted with an ultrasonic sensor for volume monitoring, measurement of the hematocrit and the air detection, with a temperature sensor for the automatic access analysis, body temperature monitoring and thermal energy balance, with a pressure sensor for the pressure monitoring and with an optical sensor for the automatic detection of blood.
  • valves M and the pump valves O have a similar design to those valves described above.
  • phantom valves which are not drawn in any more detail in this FIG. 7 , are additionally present.
  • the design and function of the phantom valves are similar to the design and function of the phantom valves discussed above.
  • Reference letter N designates safety clamps which serve to achieve a safe state during an alarm in the extracorporeal blood circuit, with them interrupting the patient line and thus any blood flow from or to the patient. To avoid unwanted compliance effects, and since the system is designed for a flow reversal, this safety function must be ensured both on the arterial side and on the venous side so that two blocking clamps N are used which can be mechanically coupled.
  • the blocking clamps should be effective as close to the patient as possible in order to be able to minimize any interference and to satisfy high safety demands. For this reason, tube clamps are used which act directly on the patient tubes.
  • a possible embodiment such as is provided here, consists of the clamping of the tubes against a clamping rail on the inner side of the door by means of a reclosable pneumatically opened clamping slide.
  • Such a system is passively spring-closing, namely without pressure and without current and so is also advantageous in the case of a failure under safety aspects.
  • FIG. 8 a fluid treatment machine 100 is shown corresponding to FIG. 7 with an inserted cassette 10 corresponding to FIG. 2 .
  • FIG. 9 a fluid treatment machine 100 is shown with a cassette 10 corresponding to the embodiment variant in accordance with FIG. 5 , with the dialyzer in the cassette here having an automatic dialysate connection K and L to the fluid treatment machine 100 .
  • the new apparatus shown here follows a strictly modular approach while achieving a high flexibility and deployment possibility also with respect to future deployment possibilities and options.
  • the integrated blood module permits the carrying out of the whole spectrum of the blood treatment procedures, namely standard hemodialysis, online hemodiafiltration, online hemofiltration and also acute treatment.
  • the machines serving the acute treatment i.e., the acute dialysis or acute filtration
  • a complex supply structure e.g. water connection
  • work is carried out practically without exception with bags with premanufactured solutions.
  • acute hemofiltration can then be carried out easily in which the substituate is supplied from a bag and filtrate is removed from the filter into an empty bag with the pumps shown. Except for the connection of the bags, no further measure is necessary in this case. It would naturally nevertheless be possible to additionally make a dialysis possible with a corresponding effort.
  • the substituate pump could alternatively be used as a dialysate supply pump if the connections inside the cassette were changed accordingly. Then dialysis fluid filled into bags could be supplied in balanced form to the filter via the membrane pump, while fluid is led out in a controlled manner via the filtrate pump. No further components would also be necessary for the fluid control in such a machine.

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Mechanical Engineering (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • External Artificial Organs (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

The invention relates to an apparatus for the treatment of a medical liquid comprising a liquid treatment machine and a cassette insertable therein substantially made of a rigid base body of the cassette with fitted chambers and passages and a foil covering them.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • This application is a continuation application of and claims priority to U.S. application Ser. No. 12/627,043, filed on Nov. 30, 2009, which is a continuation application of and claims priority to U.S. application Ser. No. 10/516,528, filed on Dec. 2, 2004, now U.S. Pat. No. 7,648,627, which is a nationalization of PCT/EP03/05377, filed on May 22, 2003 and published in German, which claims priority under 35 U.S.C. §119(a) to DE 102 24 750.1, filed on Jun. 4, 2002.
  • TECHNICAL FIELD
  • The invention relates to an apparatus for the treatment of a medical fluid comprising a fluid treatment machine and a cassette insertable therein substantially consisting of a rigid base body of the cassette with fitted chambers and passages and a foil covering them.
  • BACKGROUND
  • Cassettes are used in medical engineering, in particular to convey dialysis fluid, blood and the like.
  • A cassette can include a base body with fitted chambers and passages which is closed by a flexible foil to cover the passages and chambers. The cassette can be inserted into a special receiving chamber, e.g., in a dialysis machine. This chamber can, for example, be opened via a pivotable door. The cassette can be inserted into the chamber, with the flexible foil lying opposite a corresponding mating piece at the machine so that the cassette can be operated with the aid of actuators and sensors on the machine side.
  • Conventional extracorporeal blood circuits or blood tubing systems are usually present in a differential construction. This means that a functional division onto different components is present. Such components (e.g., bubble traps, flow chambers or injection positions) are connected to one another by tubes and are as a rule connected individually to the respective dialysis machine. The design of such blood tubing systems is very complex in manufacture and handling, with the corresponding effort naturally being extremely time consuming with more complex systems such as an online hemodiafiltration.
  • On the other hand, conventional extracorporeal blood circuits which are installed in this differential construction have the advantage that they can be designed substantially more flexibly for the respective treatment depending on the demand. Previously known apparatuses for the use of cassettes typically were only usable for a very specific application.
  • SUMMARY
  • Certain aspects of the invention relate to a generic apparatus comprising a fluid treatment machine and a cassette insertable therein such that a large flexibility for different applications is made possible while maintaining the fast and simple exchangeability.
  • In some aspects of the invention, actuators and sensors are arranged in a generic apparatus for the treatment of a medical fluid for the operation of the apparatus with an inserted cassette such that cassettes are insertable in different integration shapes.
  • Due to the clearly defined arrangement of corresponding sensors and actuators, cassettes of different complexity can be inserted into the fluid treatment machine in accordance with the desired application. It is therefore not necessary to provide different apparatus for different applications.
  • A cassette for a standard hemodialysis can thus be insertable here, for example. The corresponding pump chambers, measuring sensors and further actuators, such as valves, etc., are provided at pre-determined locations in the fluid treatment machine. Additional pumps, actuators, valves, etc. are provided in the fluid treatment machine which do not have to be actuated when the cassette is used for standard hemodialysis. They are, for example, only in use when a cassette is used for online hemodiafiltration or online hemofiltration. Further passages, pump chambers, etc. are provided at corresponding positions in the corresponding cassettes which are associated with these actuators, pumps or valves. Furthermore, a cassette for an acute dialysis treatment can be inserted in which in turn the pumps, actuators and valves provided on the side of the fluid treatment machine are associated with corresponding pumping chambers, passages, etc. The associated control electronics can be selected depending on the inserted cassette for the control of the pumps, actuators, sensors, etc.
  • DESCRIPTION OF DRAWINGS
  • Details and advantages of the invention will be explained in more detail by way of example in the following with reference to the Figures. There are shown:
  • FIG. 1: a schematic plan view of a cassette for standard hemodialysis;
  • FIG. 2: a schematic plan view of a cassette in accordance with the invention according to a further embodiment of the invention for use in online hemodiafiltration or online hemofiltration;
  • FIG. 3: a plan view of a cassette in accordance with a further embodiment of the present invention which can be used for acute treatment;
  • FIG. 4: a schematic plan view of a further aspect of the invention which substantially corresponds to that in accordance with FIG. 1, but has an integrated dialyzer;
  • FIG. 5: a further aspect of the invention which substantially corresponds to that in accordance with FIG. 2, but has an integrated dialyzer;
  • FIG. 6: a further embodiment of the invention which substantially corresponds to that in accordance with FIG. 3, but has an integrated dialyzer;
  • FIG. 7: a three-dimensional representation of a fluid treatment machine as an embodiment of the apparatus in accordance with the invention without an inserted cassette;
  • FIG. 8: a representation corresponding to FIG. 7, but with an inserted cassette;
  • FIG. 9: a representation in accordance with FIG. 7, but with a different embodiment variant of a cassette differing from the cassette shown in FIG. 8;
  • FIG. 10: a detail of a venting unit in the apparatus in accordance with the invention;
  • FIG. 11: a detailed view of a contour of a measuring chamber in a cassette in accordance with one of the aforesaid embodiment variants;
  • FIG. 12: a partially sectional representation of a pump chamber of the cassette in accordance with the present invention;
  • FIG. 13: a partially sectional representation through a passage of the cassette in accordance with an embodiment variant of the invention;
  • FIG. 14: a cross-sectional view of a valve;
  • FIG. 15: a diagrammatic view of the valve of FIG. 14 in use in a disposable cartridge;
  • FIG. 16: a perspective view of a fluid guide body having an open main passage and a secondary passage opening therein in accordance with an embodiment of the invention in a sectional representation;
  • FIG. 17: a perspective view of a base body of the cassette of FIG. 1 in a partial section, wherein a covering film is pressed onto the fluid guide body by a valve actuator and closes the secondary passage;
  • FIG. 18: a perspective view similar to FIG. 17, wherein the secondary passage is represented in its open position; and
  • FIG. 19: a schematic, 3D representation of a section of an elastic matt according to an embodiment of the present invention;
  • FIG. 20: a section along the section line A-A′ in FIG. 19;
  • FIG. 21: a section along the section line B-B′ in FIG. 19;
  • FIG. 22: a section along the section line C-C′ in FIG. 19.
  • DETAILED DESCRIPTION
  • In FIG. 1, a cassette 10 in accordance with an embodiment of the present invention is shown which can be used for standard hemodialysis. In FIG. 1, the surface of the cassette 10 is divided into a hatched region B (two partial areas) and a non-hatched region A. Both the surface of the cassette 10 and the surface of an associated machine block 108 (shown in FIG. 7) are divided into the covering surface regions A and B. Components of actuators or sensors to be coupled, which are common to all cassettes as basic variants (e.g., all the cassettes for standard hemodialysis) are accommodated in the surface region A (not hatched in FIG. 1), and the surface region B denotes a region in which actuators or sensors to be used optionally are provided in the machine block 108 (shown in FIG. 7). As discussed below, FIG. 2 illustrates a cassette that includes operable components in a region corresponding to a surface region B.
  • The cassette consists of a base body 12 of a cassette which consists of polypropylene in the embodiment shown here. A cover foil 14 (shown in FIGS. 10, 12, 13, 17, and 18) consisting, for example, of a polyolefin elastomer mixture, is applied to the base body 12 of the cassette 10. The passages and recesses, which will be looked at in more detail later, are covered by this cover foil 14. An arterial injection septum 16 is provided in the arterial line 18 to the dialyzer and a venous injection septum 20 is provided in the venous line 22 to the dialyzer. The dialyzer itself and the corresponding tube connection are not shown in any more detail in the embodiment shown here. Reference number 24 designates the blood inlet from the patient and reference number 26 designates the blood outlet to the patient. The respective tubes, which likewise consist of a polyolefin elastomer mixture, are also not shown here for reasons of simplification. Passages 28 are recessed in the base body 12 of the cassette 10. They are acted on by a row of valves 30.
  • These valves 30 have a valve body with a pressure passage and a sealing cap which cooperates with the valve body such that it closes the end of the pressure passage on the valve body side with respect to the environment, with a pressure space being able to be built up between the pressure passage and the sealing cap so that the sealing cap has a deformable sealing region for entry into the fluid passage in order to close this as required.
  • FIG. 14 shows one of the valves 30 in a sectional view, which is rotation-symmetric about a vertical axis. The valve 30 includes a valve body 112 with a pressure channel 114, which ends in a pressure chamber 116. A sealing cap 118 with a deformable area 120, which bounds the pressure chamber 116, is placed over the valve body 112.
  • The pressure channel 114 of the valve body 112 is elongated, so that it can be inserted, for example, through the body or a wall of a counterpart of the disposable cassette 10 on the device side (i.e., through the machine block 108) and can be screwed down with a lock nut 122. A thread is provided on the outer wall of the portion of the valve body 112 that forms the pressure channel 114 to allow the lock nut 122 to secure the valve body 112 to the machine block 108. The valve body 112 has sealing surfaces 124 for sealing the valve body 112 in the machine block 108. The sealing cap 118 includes protruding bulges 126, which surround the valve body 112 in such a way that they lie adjacent to the sealing surfaces 124 and are pressed when the valve 30 is assembled.
  • Still referring to FIG. 14, the upper area of the valve 30 is the area on the fluid passage side (i.e., the side nearest the cassette 10). A projection 130 of the sealing cap 118 lies on the end of the valve body 112, on the fluid passage side. A shoulder 128 of the sealing cap 118 is provided to ensure that that the sealing cap 118 fits into its associated fluid passage in the cassette 10.
  • The valve 30 is shown diagramatically in use in FIG. 15. The base body 12 of the disposable cassette 10 in which liquid passages 28 are formed is shown in diagrammatic representation. The corresponding counterpart of the disposable cartridge body on the device side (i.e., the machine block 108) is shown pressed against the cassette 10.
  • The valve 30 is inserted into a suitably shaped housing (e.g., recess) 138 of the machine block 108 and screwed down with the lock nut 122. The shoulder 128 lies adjacent to the edges of the liquid passage 28. The movement of the deformable area 120 when an excess pressure or partial vacuum is applied or with venting of the pressure channel 114 is indicated by arrow 140. Reference number 142 indicates the direction in which the pressure is applied in order to close the valve 30. As shown in FIG. 15, the housing 138 in the machine block 108 is rotation-symmetric about the pressure channel 114 of the valve 30, and the liquid passage 28 extends perpendicular to the plane of the figure.
  • A cut-out for accommodating the shoulder 128 can be provided either in the base body 12 of the cassette 10 or in the machine block 108. It is also possible for the shoulder 128 to be accommodated in a suitable opening in a cover mat located between the cassette 10 and the machine block 108.
  • For the sake of clarity, FIG. 15 does not show the cover foil 14 of the cassette 10, which closes off the fluid passage 28 against the surroundings. The cover foil 14 (shown in FIGS. 10, 12, 13, 17, and 18) can be fixed on the side of the base body 12 of the cassette 10 that is pressed against the machine block 108. The cover foil 14 is sufficiently flexible so that it can follow the deformation of the deformable area 120 of the sealing cap 118 of the valve 130.
  • For the operation of the valve 30 with the cassette 10, the valve body 112 is inserted through the housing 138 of the machine block 108, so that the pressure channel 114 extends through the machine block 108. The lock nut 122 is tightened up so that the protruding bulges 126 create a seal between the valve body 112 and the machine block 108. By simply screwing the lock nut 122 onto the valve body 112, a tight and reliable connection of the valve 30 with the machine block 108 is thus provided.
  • The machine block 108 with the valve 30 is pressed against the cassette 10, whereby the shoulders 128 of the sealing cap 118 fit tightly with the edges of the liquid passage 28. By pressing the machine block 108 against the disposable cassette 10, several valves 30 can be simultaneously fitted into their corresponding liquid passages 28 at the desired points.
  • The dialysis liquid, for example, flows through the fluid passage 28 when the valve 30 is in the opened state. If excess pressure is applied via the pressure channel 114 in the direction of the arrow 142, the deformable area 120 of the sealing cap 118 is deformed into the liquid passage 28 until the valve 30 is finally closed. The loading on the sealing cap 118 is reduced by the projection 130 of the sealing cap 118, without the movement of the deformable area 120 being significantly impaired. The cover foil 14 of the cassette 10 is deformed together with the sealing cap 118 into the liquid passage 28.
  • If the fluid passage 28 is to be opened again, the pressure channel 114 is vented and the deformable area 120 of the sealing cap 118 is relaxed. By applying a partial vacuum to the pressure channel 114, the deformable area 120 is placed against the convex curvature of the pressure chamber 116 and correspondingly increases the cross-section of the fluid passage 28. By simply applying or removing a pressurization to the pressure channel 114, therefore, the flow rate through the fluid passage 28 can be controlled.
  • When the disposable cartridge is removed, the valve 30 can be removed or replaced simply by loosening lock nut 122, e.g., for maintenance or in the event of malfunction.
  • The sealing cap 118 is a simple low-cost shaped part, which on account of its closed design can easily be cleaned and thus satisfies the hygiene requirements in dialysis, but which can also easily be replaced when necessary.
  • When the disposable cassette 10 is again compressed between the machine block 108 and the base body 12, the valve 30 fits into the fluid passage 28 very well by pressing the shoulder 128 with the edge of the fluid passage 28. On account of the elastic stretching of the deformable area 120 of the sealing cap 118, there is a very good tolerance compensation both in the depth of the fluid passage 28 as well as in respect of lateral misalignment, without a significant additional expenditure of force. The deformable area 120 guarantees that only small forces are required to block the fluid passage 28.
  • Other details regarding the valves 30 and their operation with disposable cartridges, such as the cassette 10 described above, are discussed in DE 100 46 651, which is incorporated by reference herein.
  • Referring again to FIG. 1, an arterial measuring chamber 32 and a venous measuring chamber 34 are furthermore recessed in the base body 12 of the cassette 10. The basic design of these measuring chambers is shown in FIG. 11. Referring to FIG. 11, the flow direction of the fluid, i.e., of the blood through the chambers 32, 34, is indicated by the arrows. The measuring chambers 32 and 34 have a widened passage section to be able to receive the sensors 36. The contour of the measuring chambers 32, 34 corresponds to a diffuser nozzle geometry such as is shown in FIG. 11. A diffuser 38, which runs out in a nozzle 40, is arranged in the region of the inflow region of the fluid. The widened cross-section in the diffuser 38 is relatively rapid in comparison to the narrowed cross-section in the nozzle 40. The sensors 36, which are made in the form of multi-functional sensors, are arranged in the region of the arterial or venous measuring chamber 32, 34.
  • More specifically, each of the sensors 36 for measuring selected parameters of the medical fluid passing in the arterial and venous measuring chambers 32, 34 is disposed on a measurement plate that has a peripheral seal along its outer edge and that is in contact with the flexible membrane (i.e., the foil 14). The measurement plate has an inlet that leads to the foil 14 so that a vacuum can be established between the measurement plate and the foil 14.
  • Several sensors can be mounted on the measurement plate, and since the flexible membrane (i.e., the foil 14) can be brought in close contact with the measurement plate, the medical fluids are separated from the sensors on the measurement plate only by the foil 14. Because of the peripheral seal disposed on the measurement plate, the foil 14 can be brought in close contact with the underside of the measurement plate by applying a vacuum, so that very close contact can be established between the sensors and the medical fluid in the measurement chamber. The contact surface of at least one of the sensors is preferably flush with the underside of the measurement plate, so that it is possible to establish direct measurement contact between the respective sensor and the flexible membrane.
  • Because of advances in miniaturization and integration technology of sensors, it is possible to arrange multiple sensors on an area a few square centimeters in size. Each respective sensor is preferably mounted in a recess in the measurement plate, with the measurement surface of the sensor being in flush contact with the underside of the measurement plate. The sensors are preferably securely glued to the measurement plate.
  • For example, a pressure sensor and a temperature sensor may be used. Pressure sensors have become available formed on individual semiconductor chips due to advances in integration of Microsystems, so that the chips carrying the sensor are only a few square millimeters in size. Because the sensor surface can be brought in direct contact with the foil 14, it is possible to measure both positive and negative pressures. As a result, the thermal energy balance and the venous pressure in a dialysis machine can be measured with the pressure sensor and the temperature sensor.
  • In some implementations, the seal of the measurement plate is made of a rubber ring which is inserted into a groove in the measurement plate and projects slightly above the edge of the measurement plate. As soon as a vacuum is established between the membrane (i.e., the foil 14) and the measurement plate, the foil 14 is pressed tightly against the underside of the measurement plate by the ambient air pressure, and the seal guarantees that no additional air can flow into the area between the measurement plate and the foil 14.
  • The measurement plate can be made of a metal disk into which the respective sensors are inserted. In some implementations, the metal disk is kept at a constant temperature by, for example, Peltier elements. This design permits a more accurate temperature measurement of the medical fluid.
  • Before performing the individual measurements, a vacuum is first applied to the inlet so that the film (i.e., the foil 14) is placed in close contact with the sensors. Then, the sensors are activated by a control unit (not shown), so that the respective measurements can begin.
  • The above-described sensor arrangement is described in greater detail in DE 198 37 667, which is incorporated by reference herein.
  • Referring again to FIG. 1, an arterial port 42 and a heparin port 44 are provided at the cassette, which are each connected via corresponding passages to the passage carrying the arterial blood in each case via phantom valves 46. The phantom valves 46 are used in the cassette 10 in accordance with the invention instead of conventional open T-branches. In these phantom valves, the passage wall is not interrupted from the aspect of the main blood flow. Reference number 48 designates a venous port which likewise opens into a blood-carrying passage 28, here in the venous part of the blood-carrying passages, via a phantom valve 46.
  • As FIG. 16 shows, and as discussed above, the fluid guide body (i.e., the base body 12) of the cassette 10 has a main fluid passage 28, which is integrally worked into the base body 12 and is closed by a covering film (i.e., the foil 14), which is not shown in FIG. 16.
  • The fluid guide body (i.e., the base body 12) further has a secondary passage 144 that leads away from the rear side of the base body 12, which is remote from the open side of the main passage 28, onto the opposite front side of the base body 12 and opens there into the main passage 28. As FIG. 17 shows, the secondary passage 144 passes through a base 146 of the main passage 28. The secondary passage 144 extends into the main passage 28 in the form of a volcano-like funnel 148 whose height corresponds to the depth of the main passage 28 so that an orifice 150 of the secondary passage 144 is arranged vertically coincident with the rims of the main passage 28.
  • The secondary passage 144 is positioned symmetrically in the center of the main passage 28 and extends perpendicularly to the longitudinal direction of the main passage 28. The planar designed orifice 150 is in the plane which is set up by the rims of the main passage 28.
  • As FIG. 16 shows, the funnel 148 has a streamlined cross-section. In more precise terms, the outside of the wall of the secondary passage 144 in the main passage 28 is formed in streamlined manner, with the longitudinal axis of the streamlined shape corresponding to the longitudinal axis of the main passage 28. Vortexes, turbulences and an increased flow resistance are thereby avoided at the secondary passage 144. The medical fluid flowing through the main passage 28 can flow past the secondary passage 144 in laminar fashion.
  • As FIG. 16 shows, the contours of the main passage 28 are also formed extending in streamlined fashion around the secondary passage 144. The side walls of the main passage 28 opposite the funnel 148 bulge in streamlined fashion around the funnel 148 so that the fluid flow forking around the funnel 148 finds approximately the same flow cross-section and can flow past the funnel 148 without speed changes.
  • To be able to close the open side of the secondary passage 144 and simultaneously the orifice 150 of the secondary passage 144, the covering film (i.e., the foil 14), which can be welded or connected in another way to the base body 12, lies on the base body 12. To seal the main passage 28, the foil 14 can be welded to the base body 12 along the rims of the main passage 28. The sealing can, however, also be effected by pressing the foil 14 along the rims of the main passage 28 by a valve plunger 152.
  • The valve plunger 152 has a continuous, planar plunger surface 154 that is formed by an elastic (e.g., elastomer) machine membrane. Due to the vertically coincident arrangement of the orifice 150 with the rims of the main passage 28, the secondary passage 144 can be closed without stretching of the foil 14, if the foil 14 is pressed onto the base body 12. The orifice 150 is formed for this purpose as a planar valve seat 156, which is in the plane set up by the rims of the main passage 28 and forms the front end of the funnel 148.
  • FIG. 17 shows the closed state of the secondary passage 144. The plunger surface 154 is pressed onto the base body 12. Additional pressure can be applied by an actuating part 158 in the region of the orifice 150 of the secondary passage 144 in order to achieve a reliable sealing of the secondary passage 144.
  • To open the secondary passage 144, the actuating part 158, which is connected to the plunger surface 154 in the region of the secondary passage orifice 150, is moved away from the base body 12. The plunger surface 154 is thereby raised from the orifice 150 of the secondary passage 144 in the region thereof. As FIG. 18 shows, the plunger surface 154 thereby deforms, which is allowed by the design of the same as an elastic membrane.
  • The foil 14 also lifts off the orifice 150 of the secondary passage 144 due to the raising of the plunger surface 154. The pressure of the flow in the main passage 28 presses the foil 14 away from the orifice 150. Optionally, this can also be supported actively by the interposition of a vacuum between the plunger surface 154 and the foil 14, which is helpful in particular when a sample should be sucked from the fluid flow in the main passage 28 through the secondary passage 144.
  • When the actuating part 158 lifts, the foil 14 stretches elastically. The deformation is here very low, however. It is in particular not plastic so that a formation of creases in the subsequent re-closing of the orifice 150 is prevented. As FIG. 18 shows, the secondary passage 144 is in flow communication with the main passage 28 in the raised state of the foil 14.
  • Other details regarding the phantom valves 46 are described in DE 100 53 441, which is incorporated by reference herein.
  • Referring again to FIG. 1, reference numbers 50 designate two pump chambers which serve to pump the blood. The design of the pump chambers 50 is shown in detail in FIG. 12. The pump chambers 50, which are activated via membrane pumps provided at the machine side (i.e., in the machine block 108), have substantially tangential inlets and outlets for a uniform throughflow of the total chamber, as shown in FIG. 1. The shape of the pump chambers 50 is pre-determined by the correspondingly shaped base body 12 of the cassette 10 and can be approximately described as a spherical section. At the periphery, the base body 12 of the cassette 10 has a raised edge 52 around the pumping chambers 50 which serves as a stop bead. In addition, as shown in FIG. 12, the peripheral edge of the spherical section is set somewhat lower so that in the pressing-out phase, that is in the phase in which the cover foil 14 is moved toward the base body 12 of the cassette 10, a flushing edge or flushing passage 54 is formed. The flushing edge or flushing passage 54 is advantageously made in that the spherical pump surface at the machine side (i.e., the spherical pump surface in the machine block 108), which is not shown in FIG. 12, has a smaller radius than the radius of the pump chamber 50 at the cassette side. The radius difference Δr is shown in FIG. 12. A wide flushing edge or flushing passage 54 is hereby formed. This flushing edge or flushing passage 54 is an annular space for the pumped blood in the extreme pressing-out position. This free annular space, on the one hand, avoids blood damage by being trapped between the foil surface and the injection molded surface (i.e., the base body 12) at the end of the pressing-out phase and, on the other hand, blood damage due to high flow speeds and shearing strains which would result at the start of the start-up phase if no free annular space were provided.
  • In the upper region of the cassette in the installed state, a venting chamber 56 is formed which is shown again in FIG. 10 in a sectional representation. A venting membrane 58 is arranged in this venting chamber via which correspondingly collected air can be separated since it is made as a partially permeable membrane which preferably has hydrophobic or oleophobic properties. Expanded or sintered polytetrafluoroethylene can preferably be used as the venting membrane. A venting stub 60 is arranged above the venting membrane 58 and its cooperation with the fluid treatment machine (not shown in more detail here) will be described later.
  • Bubbles are trapped in the venting chamber 56 by a slowing down of the blood flow. As shown in FIG. 10, a rotation flow is generated for effective air separation with minimum area requirements on the cassette 10. In this process, the generation of the final rotation flow is only created in the operating state of the cassette 10 in the fluid treatment machine 100. The cover foil 14 of the cassette 10 is pulled into the fluid treatment machine 100 by a corresponding vacuum coupling system of which only one vacuum suction passage 102 is shown in FIG. 10. An almost circular cross-section of the venting chamber 56 is thereby formed. The rotation flow of the blood is supported in that the passage opening into the venting chamber 56 also runs—together with its cover foil 14—slightly into the machine side so that an almost tangential inflow within the chamber is achieved. An effective suction can take place at the machine side at the venting stub 60. A low filling volume results overall here in the venting chamber 56 as a result of the construction.
  • The basic design of the passages 28 can be explained with reference to FIG. 13. Generally, care is taken in the passage design of the passages 28 that a smooth foil surface and smooth passage surfaces are provided. Steps, dead spaces, turbulence and impact surfaces are avoided. Low changes in direction and speed are aimed for. Separations of flow are largely avoided. All passages 28 and also chambers 50 have an edge bead 52 which accompanies the passages and faces the cover foil 14. On insertion of the cassette 10 into the fluid treatment machine 100, the foil 14 is pressed onto the edge bead 52 such that all passages 28 are sealed against the environment. At the rear of the cassette, i.e., at the outer side of the passage wall, webs 62 are formed which accompany the passages and via which the rear pressing force is guided to the edge beads 52 in order thus to achieve a uniform linear distribution of force.
  • It can also be explained with reference to FIG. 13 that the base body 12 of the cassette 10 is welded to the cover foil 14 at the outer edge 64.
  • As shown in FIG. 1, the cassette 10 has a recessed centering fork 66 as a positioning aid which receives a centering pin on the machine side on insertion. Stop noses 68 are furthermore molded on which contact against corresponding machine surfaces on insertion. The cassette 10 is thereby guided in height and angle. When pressing the cassette 10 into the fluid treatment machine 100, a latching with the fluid treatment machine takes place at a snap element not shown in more detail here such that the cassette 10 is fixed in an aligned manner. The cassette 10 has a molded handle 70 at the side disposed opposite the centering fork 66 for simplified handling.
  • The arterial injection septum 16 or the venous injection septum 20 are made in the embodiment shown here, in contrast to a conventional injection position, such that their base body is formed by the base body 12 of the cassette itself so that here only the elastic septum is fixed by a snap ring (not shown in detail here). The septum consists of an elastomer in the embodiment shown here.
  • FIG. 4 shows a modified embodiment of the cassette in accordance with FIG. 1. This cassette 10 shown in FIG. 4 also serves standard hemodialysis and largely shows an identical design to the cassette 10 in accordance with FIG. 1. To this extent, a detailed description of the already described components of the cassette 10 is superfluous. However, instead of the handle 70 in the embodiment in accordance with FIG. 1, a dialyzer 72 is integrated in the side of the cassette 10, with the lines 18 and 22 to the dialyzer opening directly into the dialyzer. The dialysate connections at the dialyzer, which can have a conventional design, are designated by 74 and 76.
  • A cassette 10 is shown in FIG. 2 which is designed as an online hemodiafiltration cassette. It becomes clear from the arrangement of the different elements that the base body 12 of the cassette 10 starts from that base body of a cassette such as has already been described in FIG. 1 with reference to the embodiment for standard hemodialysis. All elements which are known from this configuration can be found in the same manner in the embodiment variant in accordance with FIG. 2 for online hemodiafiltration. To this extent, they will not be additionally explained again. However, those parts will be explained which are necessary for the operation of the hemodiafiltration cassette. This includes the substituate connector 80 via which the substituate fluid is fed into the passages 28. Substituate passage valves 82 are provided at the passages and the passages 28 can be closed at the appropriate positions via these valves 82. The substituate fluid is guided into two parallel pump chambers 84, which form substituate pump chambers, via the passages 28. The substituate pump chambers 84 substantially correspond to the pump chambers for the blood 50 as they have previously already been described in detail. Starting from the passage 28, the substituate fluid is guided through a substituate tunnel 86 which is disposed on the opposite side of the base body 12 of the cassette 10. The substituate tunnel 26 is suitably closed at the rear side, e.g., by a welded foil. The substituate fluid 86 can be led into the passage 28 carrying the blood via a port for pre-dilution 88 or via a port for post-dilution 90. The ports are again made as phantom valves of the type described above.
  • The substituate region substantially formed by the substituate pump chambers 84 is surrounded by a substituate weld rim 92 to which the cover foil 14 is sealingly welded so that this region of the cassette 10 processing substituate is separated from the blood-carrying region.
  • In FIG. 5, a modification of the embodiment variant in accordance with FIG. 2 is shown. Here, too, in a similar manner to the embodiment variant in accordance with FIG. 4, a dialyzer 72 is integrated directly into the cassette 10.
  • In FIG. 3, a cassette 10 for acute treatment is shown as a further integrated embodiment of the cassette. It is designed identically to the embodiment variant in accordance with FIG. 1 in the region of the blood treatment part. With respect to the substituate part, it partly corresponds to the embodiment in accordance with FIG. 2, with here only one substituate pump chamber 84 being provided which is fed by the substituate fluid led in via the substituate connector 80 and the passage 28. In a similar manner as to the embodiment variant in accordance with FIG. 2, substituate passage valves 82 are provided before and after the substituate pump chamber 84. The further pump chamber, which is designated by 94 in the present embodiment variant for acute treatment, is connected to a filtrate outlet 96 via a passage 28 and opens into a filtrate connection 98 which is connected to the dialyzer not shown in any more detail here.
  • In FIG. 6, in turn, a modified embodiment variant of the cassette 10 in accordance with FIG. 3 is shown. Here, a dialyzer 72 is in turn integrated instead of the handle, with here a connection 99 being provided between the dialyzer 72 and the passage 28 which carries the filtrate and which leads to the filtrate pump chamber 94.
  • In FIG. 7, an embodiment of the fluid treatment machine 100 is shown without an inserted cassette 10. This fluid treatment machine 100 is designed such that all aforesaid cassettes can be inserted, with a basic extracorporeal blood circuit, i.e. a standard dialysis using an external dialyzer, being carried out by a corresponding program selection, for example on insertion of the cassette in accordance with the embodiment variant in accordance with FIG. 1. When a cassette 10 in accordance with the embodiment of FIG. 2 is used, online hemodiafiltration or an online hemofiltration variant is, for example realized by use of the components required for this purpose with, optionally, automatic connections (not shown) to the fluid circuit of the basic unit. Highly integrated variants with an integrated dialyzer and an automatic dialyzer connection are also possible such as are shown by way of the cassette in the embodiment variants in accordance with FIGS. 4 and 5. Acute dialysis treatment is possible when a cassette 10 is used in accordance with the embodiment of FIG. 3.
  • The fluid treatment machine 100 substantially consists of a frame 104 which surrounds and/or includes or receives the most important components. A door 106 is fitted to the frame 104, on the one hand, and the machine block 108 is guided in the frame, on the other hand. All forces occurring between the door 106 and the interior of the unit are absorbed by means of the frame 104, namely the door hinge, door latch, pressing actuator system and the rear wall. The frame 104 furthermore contains the door latch 110. The cassette 10 is received between the door 106 and the machine block 108, as shown in the FIGS. 8 and 9, and is sealed by pressing. Sensor system elements are included in the cassette region of the machine and they detect whether a cassette is correctly positioned in the fluid treatment machine. These, or further sensor system elements, can be designed such that they are suitable for recognizing the cassette type (e.g. with the aid of a barcode on the cassette).
  • The important elements for the control and monitoring of the extracorporeal blood circuit, such as pumps, valves, the sensor system, etc., are contained in the machine block 108. This machine block 108 establishes the most important interface to the cassette 10. The cassette surface is coupled to the unit here and the sealing of the cassette 10, and thus the fixing of the flow paths, takes place by this. The machine block 108 is guided movably in the frame and fixes the cassette 10, as already described above, until the door 106 is closed.
  • Hydraulic piston pumps are contained in the fluid treatment machine which are not shown in detail in FIGS. 7, 8 and 9 here. They are, on the one hand, blood pumps or optional substituate feed pumps or ultrafiltrate pumps. They are hydraulically connected to the pump chambers (i.e., the blood pump chambers) C, D, and, in some cases, they are hydraulically connected to the optional filtrate pump chambers and/or the optional substituate pump chambers E, F. Furthermore, compressors for the generation of the required pneumatic pressure (overpressure or vacuum) not shown in more detail here are contained in the fluid treatment machine 100. The fluid treatment machine 100 furthermore has—in a manner not shown in more detail—a pneumatic buffer container for the compensation of pressure fluctuations, a main electronics box, a heparin injection pump and a blood pressure monitor module.
  • A pressing actuator system on the rear wall of the frame 104, likewise not shown in more detail, must be emphasized here. An inflatable air cushion is integrated here which can move the whole machine block 108, which is movably supported in the frame 104, and press it against the closed door 106.
  • Furthermore, instead of individual air-carrying tubes, an air distributor plate is provided at the machine block 108 which contains main connections for the pneumatics and which guides compressed air and vacuum to the valves and actuators via passages integrated there without any substantial tubing, with them simultaneously terminating the machine block with respect to the interior of the fluid treatment machine 100.
  • Optional modules can be provided in the fluid treatment machine 100 for the carrying out of the online hemodiafiltration. For instance, an online feed port for the automatic coupling of a cassette 10 to a dialysate circuit or an online flushing port for the return of flushing solution can be contained here.
  • The door 106 must be open for the insertion of the cassette 10. The cassette 10 is inserted and, after positioning of the centering fork 66, is fixed to the surface of the machine block by means of a snap hook.
  • The side of the machine block 108 facing the cassette 10 is lined with a soft elastomer mat 160 (shown in FIG. 19), which seals the cassette 10 after pressing has taken place.
  • Referring to FIG. 19, during use, the elastic matt 160 is arranged between the fluid treatment machine (i.e., the machine block 108), of which no detail is shown here, and the cassette 10. On the so-called machine side, namely on the surface which, when assembled, faces the fluid treatment machine 100, matt channels 162 and connection channels 164 are formed. Furthermore, a recess 166 is arranged in the elastic matt 160, into which in the assembled condition a machine-mounted valve, for example, engages and establishes a seal all around. It is easy to see that this machine-mounted valve interrupts the respective matt channel 162 which happens to join the recess 166. In order to still make an air extraction possible, a connection channel 164 has been provided which connects the two interrupted branches of the matt channel 162 and connects them in turn with a further, parallel matt channel 162. The structure shown here is, of course, only an example and can be changed in any way. While the channel structures are provided on the machine side of the elastic matt 160, the disposable side, namely the side facing the cassette, is executed as a smooth, i.e., flat surface.
  • By referring to the sectional views of FIGS. 20 to 22, the structure of the individual channels can be explained in more detail. The section A-A′ as per FIG. 19 is shown in FIG. 20 where a matt channel 162 becomes visible which, with the elastic matt 160 used here having a thickness of 4 mm, has a depth of 3 mm and a width of 2 mm. In the remaining matt material below the channel 162, which has a thickness of 1 mm, a slit 168 is placed which takes on a type of valve function. When a vacuum is applied, the two areas of the elastic matt 160 adjacent to the slit 168 will open and enable the extraction of air gas. In an idle state or when an equilibrium is obtained, the two adjacent areas return to their original position and close the opening. In order to enhance this return effect, areas between the slits 168 are provided in the matt channel 162, which on the one hand do not have a slit and, on the other hand, are less deeply recessed in the area of matt channel 162. Referring to FIG. 21, a corresponding area can be seen in section B-B′, which shows that, while the matt channel 162 in this area has the same width of 2 mm, it only has a depth of 1 mm.
  • Referring to FIG. 22, a connection channel 164 is shown in the sectional view of C-C′, where said channel is narrower and not as deep as the matt channel 162, which can be seen clearly in this view. In this case, both the width of the connection channel 164 and the depth are one millimeter each.
  • With the elastic matt 160, it is guaranteed that the interior space of the fluid treatment machine, in its idle state, is protected by the self-closing feature of slits 168. At the same time, an even air extraction is achieved between the fluid treatment machine and the cassette across its entire surface because parallel extraction takes place via numerous slits 168. Thus, a minor blockage may not cause any detrimental effects for other areas.
  • With a thin matt 160, as it has been presented in the embodiment for example, the opening effect of the slits can be utilized by applying a vacuum.
  • Since the elastic matt 160 is exchangeable, it can be replaced easily after contamination or a fault. It is especially advantageous that no structured shapes are required for the fixed components on the machine. On the side of the elastic matt 160 facing the machine, open structures can be formed so that no sub-surface tunnels or other closed structures are required. On the other hand, the side of the elastic matt 160 facing the cassette is largely formed as a smooth, closed surface which can be cleaned easily for example.
  • Other details regarding the elastic matt 160 are described in DE 101 57 924.1, which is incorporated by reference herein.
  • Referring again to FIG. 7, after closing and locking the door 106, pressing takes place by inflating the aforesaid air cushion. On opening and removing the cassette 10, the pressing is cancelled again by letting out the air in the air cushion before opening the door 106.
  • To achieve a sufficient pressing and to prevent a tilting of the machine block 108 by a non-uniform introduction of force, the air cushion has approximately the size of the machine block 108 or of the cassette 10.
  • Since, however, further components, for example, control valves or the air distributor plate with the control valves, are now disposed between the air cushion and the machine block, the force transmission takes place by means of spacer bolts.
  • The traction between the door 106, the frame 104 and the rear wall takes place by the door hinge, the latch 110 and connection bolts, not shown in any more detail here, between the frame and the rear wall.
  • As already mentioned, a constant pressing of the cassette 10 must take place for a proper operation. For this purpose, it is necessary for the door 106 to be locked during the treatment. This locking takes place via two latching bolts (not shown in any more detail here) at the upper right hand and lower right hand door region, with these moving into two corresponding bores inside the door 106 on actuation, which takes place automatically. The moving in and out takes place pneumatically. An erroneous opening of the door 106 on a failure of the pneumatics is precluded by the bolts moved into the door and by the lateral forces occurring by the pressure load of the door. To check whether the latching has taken place, Hall proximity sensors can be integrated which detect the movement of the bolts. In addition, this signal can be linked to information on the door position which can be picked up by a separate sensor. In addition, the latching bolt not shown in any more detail here can have a latch connection. This latch connection consists of a spring-loaded latch ball on the door side which latches into a corresponding arch of the latch bolt and can hold the door in the corresponding position. An introduction slope is provided for the simplified latching. To open the door from the latch position, the latch ball present here is drawn back by means of a mechanical system.
  • On the side of the fluid treatment machine 100, the blood circuit substantially consists of at least one hydraulically controlled membrane pump having two independent pump chambers C and D which can be used as a highly precise flow pump or as a volumetric metering unit, a row of valves M, O and clamps N for the control of the flow path, a highly integrated sensor system G, H required for monitoring and control, an active air extractor, i.e., an air separation chamber I with a connected cassette venting A, of the blood circuit (air-free circuit) and a door 106 to fix the cassette 10.
  • The fluid treatment machine 100 respectively comprises a pneumatic system for the overpressure and a pneumatic system for the underpressure. The underpressure serves, for example, to apply an underpressure between the foil 14 of the cassette 10 and the unit side to prevent a passage restriction on the plastic deformation of the foil, to raise the foil at feed positions and thus to be able to keep the access free, to avoid air compliance in the pump devices and to be able to ensure an air-free coupling between the sensor and the foil at specific sensor positions. The air suction requires openings in the unit side and a suction unit, i.e., a vacuum pump, connected to it, wherein the vacuum distribution should be ensured as uniformly and as reliably as possible over the whole surface. In the idling state, the openings should be at least largely closed to permit a good cleaning here. In operation, however, a problem-free air suction should be possible. This problem is solved by the elastomer mat of the type described above.
  • In the cassette 10, no passage seals are contained except for the edge region and some safety weld connections. The sealing of all flow paths and passages must therefore take place by pressing. For this purpose, the cassette has sealing beads 52 on the passage rims which have already been described above and which are sealable on the pressing of the disposables between the machine block 108 and the door 106 by pressing into the elastic mat.
  • The air distributor plate not shown in any more detail here is located on the rear side of the machine block 108 and is connected to the, for example, two membrane pumps of the pneumatic system, namely the overpressure pump and the underpressure pump. The air distributor plate is sealed with respect to the rear side of the machine block by a sealing mat and permits the compressed air and vacuum feed via integrated passage structures so that every valve does not need its own tubing. A plurality of circuits are present on the air distributor plate, namely a vacuum circuit, a compressed air circuit which is directly connected to the compressor for the supply of components which always need compressed air, a compressed air circuit for the protection of sensitive components which may only be charged with compressed air under certain states, with it also being separable from the compressor by an on/off valve and an exhaust circuit.
  • By integration of a plurality of control valves on the air distributor plate, the electrical supply can also be collected via a small control board. Since a plurality of valves are only needed with specific options, a modular retrofitting capability must be ensured.
  • The sensor system and the pump connections are guided through the plate through apertures and cut-outs.
  • Sensors which are collected in integrated sensor modules in the present fluid treatment machine 100 are required for the monitoring and control of the extracorporeal blood circuit. Two respective modules work together as a pair. One module is accommodated in the door 106 and the counter-piece in the machine block 108. Both the arterial branch should be monitored by the arterial measuring chamber G and the venous branch by the venous measuring chamber H. The integrated measurement sensor system is described in detail in the German patent applications DE 198 37 667 A and DE 101 43 137 of the same patent applicant. The sensors together have the following properties or provide the following possibilities:
  • measurement and monitoring of the blood volume;
  • measurement of the hematocrit;
  • measurement and monitoring of the thermal energy balance;
  • measurement and monitoring of the body temperature;
  • measurement of the conditions of the fistula (with circulation);
  • air detection;
  • fistula pressure measurement.
  • A multi-sensor module is usually fitted with an ultrasonic sensor for volume monitoring, measurement of the hematocrit and the air detection, with a temperature sensor for the automatic access analysis, body temperature monitoring and thermal energy balance, with a pressure sensor for the pressure monitoring and with an optical sensor for the automatic detection of blood.
  • The valves M and the pump valves O have a similar design to those valves described above.
  • In addition to the aforesaid valves which are shown in FIG. 7, so-called phantom valves, which are not drawn in any more detail in this FIG. 7, are additionally present. The design and function of the phantom valves are similar to the design and function of the phantom valves discussed above.
  • Reference letter N designates safety clamps which serve to achieve a safe state during an alarm in the extracorporeal blood circuit, with them interrupting the patient line and thus any blood flow from or to the patient. To avoid unwanted compliance effects, and since the system is designed for a flow reversal, this safety function must be ensured both on the arterial side and on the venous side so that two blocking clamps N are used which can be mechanically coupled.
  • The blocking clamps should be effective as close to the patient as possible in order to be able to minimize any interference and to satisfy high safety demands. For this reason, tube clamps are used which act directly on the patient tubes.
  • A possible embodiment, such as is provided here, consists of the clamping of the tubes against a clamping rail on the inner side of the door by means of a reclosable pneumatically opened clamping slide. Such a system is passively spring-closing, namely without pressure and without current and so is also advantageous in the case of a failure under safety aspects.
  • In FIG. 8, a fluid treatment machine 100 is shown corresponding to FIG. 7 with an inserted cassette 10 corresponding to FIG. 2. In FIG. 9, in contrast, a fluid treatment machine 100 is shown with a cassette 10 corresponding to the embodiment variant in accordance with FIG. 5, with the dialyzer in the cassette here having an automatic dialysate connection K and L to the fluid treatment machine 100.
  • The new apparatus shown here follows a strictly modular approach while achieving a high flexibility and deployment possibility also with respect to future deployment possibilities and options. The integrated blood module permits the carrying out of the whole spectrum of the blood treatment procedures, namely standard hemodialysis, online hemodiafiltration, online hemofiltration and also acute treatment.
  • It must be pointed out with respect to the acute treatment that the machines serving the acute treatment, i.e., the acute dialysis or acute filtration, have to have a simple design in order to be able to be transported corresponding easily and to be able to work without a complex supply structure (e.g. water connection). In this system, therefore, work is carried out practically without exception with bags with premanufactured solutions. Using the embodiments shown in FIGS. 3 to 6, acute hemofiltration can then be carried out easily in which the substituate is supplied from a bag and filtrate is removed from the filter into an empty bag with the pumps shown. Except for the connection of the bags, no further measure is necessary in this case. It would naturally nevertheless be possible to additionally make a dialysis possible with a corresponding effort. Furthermore, the substituate pump could alternatively be used as a dialysate supply pump if the connections inside the cassette were changed accordingly. Then dialysis fluid filled into bags could be supplied in balanced form to the filter via the membrane pump, while fluid is led out in a controlled manner via the filtrate pump. No further components would also be necessary for the fluid control in such a machine.
  • Each of these types of treatment can take place both in two-needle and in single-needle mode. Reference is made here to the German patent DE 100 42 324 C1 with respect to the description of the two-needle or single-needle mode.
  • Other embodiments are within the scope of the following claims.

Claims (20)

1. A dialysis system, comprising:
a dialysis fluid cassette comprising a base and a flexible membrane attached to the base, the base and the flexible membrane forming a chamber therebetween; and
a dialysis machine having a cassette compartment configured to receive the dialysis fluid cassette, the dialysis machine comprising a moveable piston that substantially aligns with the chamber of the dialysis fluid cassette when the dialysis fluid cassette is disposed in the cassette compartment,
wherein the chamber and the piston are configured such that a passage is formed between the membrane and a portion of the base that forms the chamber when the dialysis fluid cassette is disposed in the cassette compartment and the piston is fully advanced.
2. The dialysis system of claim 1, wherein the passage is an annular passage.
3. The dialysis system of claim 2, wherein the annular passage is formed between an inner surface of the chamber and a portion of the membrane that is adjacent an outer surface of the piston.
4. The dialysis system of claim 3, wherein a portion of the chamber and a head of the piston are hemispherical, and, in the region of the passage, a diameter of the chamber is greater than a diameter of the head of the piston.
5. The dialysis system of claim 1, wherein the chamber is formed between the membrane and a recessed portion of the base, the recessed portion having a cylindrical region and a semispherical region.
6. The dialysis system of claim 5, wherein an inner surface of the cylindrical region of the recessed portion of the base defines a portion of the passage.
7. The dialysis system of claim 1, wherein the base comprises a raised projection that extends around a periphery of the chamber.
8. The dialysis system of claim 7, wherein the flexible membrane of the dialysis fluid cassette contacts the raised rims extending from the base of the dialysis fluid cassette when the dialysis fluid cassette is pressed against a machine block of the dialysis machine during use.
9. The dialysis system of claim 1, wherein the chamber is a fluid pump chamber.
10. The dialysis system of claim 9, wherein the base defines tangential inlets and outlets in fluid communication with the fluid pump chamber.
11. A dialysis fluid cassette, comprising:
a dialysis fluid cassette comprising a base and a flexible membrane attached to the base, the base and the flexible membrane forming a chamber therebetween, wherein the cassette is configured to be disposed within a cassette compartment of a dialysis machine such that a piston of the dialysis machine aligns with the chamber,
wherein a passage is formed between the membrane and a portion of the base that forms the chamber when the dialysis fluid cassette is disposed in the cassette compartment of the dialysis machine and the piston of the dialysis machine is fully advanced.
12. The dialysis fluid cassette of claim 1, wherein the passage is an annular passage.
13. The dialysis fluid cassette of claim 12, wherein the annular passage is formed between an inner surface of the chamber and a portion of the membrane that is adjacent an outer surface of the piston.
14. The dialysis fluid cassette of claim 13, wherein a portion of the chamber and a head of the piston are hemispherical, and, in the region of the passage, a diameter of the chamber is greater than a diameter of the head of the piston.
15. The dialysis fluid cassette of claim 11, wherein the chamber is formed between the membrane and a recessed portion of the base, the recessed portion having a cylindrical region and a semispherical region.
16. The dialysis fluid cassette of claim 15, wherein an inner surface of the cylindrical region of the recessed portion of the base defines a portion of the passage.
17. The dialysis fluid cassette of claim 11, wherein the base comprises a raised projection that extends around a periphery of the chamber.
18. The dialysis fluid cassette of claim 17, wherein the flexible membrane of the dialysis fluid cassette contacts the raised rims extending from the base of the dialysis fluid cassette when the dialysis fluid cassette is pressed against a machine block of the dialysis machine during use.
19. The dialysis fluid cassette of claim 11, wherein the chamber is a fluid pump chamber.
20. The dialysis fluid cassette of claim 19, wherein the base defines tangential inlets and outlets in fluid communication with the fluid pump chamber.
US13/401,472 2002-06-04 2012-02-21 Medical Fluid Cassettes and Related Systems Abandoned US20120181225A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/401,472 US20120181225A1 (en) 2002-06-04 2012-02-21 Medical Fluid Cassettes and Related Systems

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DEDE10224750.1 2002-06-04
DE10224750A DE10224750A1 (en) 2002-06-04 2002-06-04 Device for the treatment of a medical fluid
US10/516,528 US7648627B2 (en) 2002-06-04 2003-05-22 Device for treating a medical liquid
US12/627,043 US8142653B2 (en) 2002-06-04 2009-11-30 Medical fluid cassettes and related systems
US13/401,472 US20120181225A1 (en) 2002-06-04 2012-02-21 Medical Fluid Cassettes and Related Systems

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US12/627,043 Continuation US8142653B2 (en) 2002-06-04 2009-11-30 Medical fluid cassettes and related systems

Publications (1)

Publication Number Publication Date
US20120181225A1 true US20120181225A1 (en) 2012-07-19

Family

ID=29594250

Family Applications (11)

Application Number Title Priority Date Filing Date
US10/516,528 Active - Reinstated 2025-05-17 US7648627B2 (en) 2002-06-04 2003-05-22 Device for treating a medical liquid
US12/627,043 Expired - Fee Related US8142653B2 (en) 2002-06-04 2009-11-30 Medical fluid cassettes and related systems
US13/237,149 Expired - Lifetime US8377293B2 (en) 2002-06-04 2011-09-20 Dialysis fluid cassettes and related systems and methods
US13/401,419 Expired - Lifetime US8721883B2 (en) 2002-06-04 2012-02-21 Medical fluid cassettes and related systems
US13/401,472 Abandoned US20120181225A1 (en) 2002-06-04 2012-02-21 Medical Fluid Cassettes and Related Systems
US13/401,543 Expired - Lifetime US8435408B2 (en) 2002-06-04 2012-02-21 Medical fluid cassettes and related systems
US13/401,429 Expired - Lifetime US8366921B2 (en) 2002-06-04 2012-02-21 Dialysis systems and related methods
US13/728,162 Expired - Fee Related US8926835B2 (en) 2002-06-04 2012-12-27 Dialysis systems and related methods
US13/734,209 Expired - Fee Related US9101709B2 (en) 2002-06-04 2013-01-04 Dialysis fluid cassettes and related systems and methods
US14/571,645 Expired - Lifetime US9827359B2 (en) 2002-06-04 2014-12-16 Dialysis systems and related methods
US15/805,374 Expired - Lifetime US10471194B2 (en) 2002-06-04 2017-11-07 Dialysis systems and related methods

Family Applications Before (4)

Application Number Title Priority Date Filing Date
US10/516,528 Active - Reinstated 2025-05-17 US7648627B2 (en) 2002-06-04 2003-05-22 Device for treating a medical liquid
US12/627,043 Expired - Fee Related US8142653B2 (en) 2002-06-04 2009-11-30 Medical fluid cassettes and related systems
US13/237,149 Expired - Lifetime US8377293B2 (en) 2002-06-04 2011-09-20 Dialysis fluid cassettes and related systems and methods
US13/401,419 Expired - Lifetime US8721883B2 (en) 2002-06-04 2012-02-21 Medical fluid cassettes and related systems

Family Applications After (6)

Application Number Title Priority Date Filing Date
US13/401,543 Expired - Lifetime US8435408B2 (en) 2002-06-04 2012-02-21 Medical fluid cassettes and related systems
US13/401,429 Expired - Lifetime US8366921B2 (en) 2002-06-04 2012-02-21 Dialysis systems and related methods
US13/728,162 Expired - Fee Related US8926835B2 (en) 2002-06-04 2012-12-27 Dialysis systems and related methods
US13/734,209 Expired - Fee Related US9101709B2 (en) 2002-06-04 2013-01-04 Dialysis fluid cassettes and related systems and methods
US14/571,645 Expired - Lifetime US9827359B2 (en) 2002-06-04 2014-12-16 Dialysis systems and related methods
US15/805,374 Expired - Lifetime US10471194B2 (en) 2002-06-04 2017-11-07 Dialysis systems and related methods

Country Status (8)

Country Link
US (11) US7648627B2 (en)
EP (3) EP2308525B1 (en)
JP (3) JP4537198B2 (en)
CN (3) CN101676002B (en)
AU (1) AU2003240694A1 (en)
DE (1) DE10224750A1 (en)
ES (2) ES2529095T3 (en)
WO (1) WO2003101510A1 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100200486A1 (en) * 2007-09-10 2010-08-12 Guenther Goetz Device and method for treating a medical fluid and medical cassette
US9943634B2 (en) 2009-03-10 2018-04-17 Fresenius Medical Care Deutschland Gmbh Device for connecting multi-functional disposable cassette to extracorporeal blood treatment apparatus
US10143791B2 (en) 2011-04-21 2018-12-04 Fresenius Medical Care Holdings, Inc. Medical fluid pumping systems and related devices and methods
US10463777B2 (en) 2012-06-08 2019-11-05 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
US10471194B2 (en) 2002-06-04 2019-11-12 Fresenius Medical Care Deutschland Gmbh Dialysis systems and related methods
US10507276B2 (en) 2009-07-15 2019-12-17 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
USD917045S1 (en) 2018-08-16 2021-04-20 Deka Products Limited Partnership Slide clamp
US11478755B2 (en) 2019-08-15 2022-10-25 Fenwal, Inc. Small volume processing systems and methods
USD1004412S1 (en) 2019-08-16 2023-11-14 Deka Products Limited Partnership Slide clamp assembly

Families Citing this family (231)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852090B2 (en) 1997-02-14 2005-02-08 Nxstage Medical, Inc. Fluid processing systems and methods using extracorporeal fluid flow panels oriented within a cartridge
US6877713B1 (en) 1999-07-20 2005-04-12 Deka Products Limited Partnership Tube occluder and method for occluding collapsible tubes
US7780619B2 (en) 1999-11-29 2010-08-24 Nxstage Medical, Inc. Blood treatment apparatus
US6497676B1 (en) 2000-02-10 2002-12-24 Baxter International Method and apparatus for monitoring and controlling peritoneal dialysis therapy
US20050010158A1 (en) * 2001-05-24 2005-01-13 Brugger James M. Drop-in blood treatment cartridge with filter
US7241272B2 (en) 2001-11-13 2007-07-10 Baxter International Inc. Method and composition for removing uremic toxins in dialysis processes
US7544179B2 (en) 2002-04-11 2009-06-09 Deka Products Limited Partnership System and method for delivering a target volume of fluid
US7153286B2 (en) 2002-05-24 2006-12-26 Baxter International Inc. Automated dialysis system
US7175606B2 (en) 2002-05-24 2007-02-13 Baxter International Inc. Disposable medical fluid unit having rigid frame
WO2004009158A2 (en) 2002-07-19 2004-01-29 Baxter International Inc. Systems and methods for performing peritoneal dialysis
US7238164B2 (en) 2002-07-19 2007-07-03 Baxter International Inc. Systems, methods and apparatuses for pumping cassette-based therapies
EP1539271B1 (en) 2002-09-11 2014-04-16 Fresenius Medical Care Deutschland GmbH Blood treatment device for returning blood
US7686778B2 (en) * 2003-01-15 2010-03-30 Nxstage Medical, Inc. Waste balancing for extracorporeal blood treatment systems
US8235931B2 (en) 2003-01-15 2012-08-07 Nxstage Medical, Inc. Waste balancing for extracorporeal blood treatment systems
EP1680155B2 (en) 2003-10-28 2015-11-04 Baxter International Inc. Dialysis machine with improved integrity test
US8029454B2 (en) 2003-11-05 2011-10-04 Baxter International Inc. High convection home hemodialysis/hemofiltration and sorbent system
US8038639B2 (en) 2004-11-04 2011-10-18 Baxter International Inc. Medical fluid system with flexible sheeting disposable unit
US8803044B2 (en) 2003-11-05 2014-08-12 Baxter International Inc. Dialysis fluid heating systems
US7744553B2 (en) 2003-12-16 2010-06-29 Baxter International Inc. Medical fluid therapy flow control systems and methods
US7476209B2 (en) * 2004-12-21 2009-01-13 Therakos, Inc. Method and apparatus for collecting a blood component and performing a photopheresis treatment
US7935074B2 (en) 2005-02-28 2011-05-03 Fresenius Medical Care Holdings, Inc. Cassette system for peritoneal dialysis machine
US20060195064A1 (en) * 2005-02-28 2006-08-31 Fresenius Medical Care Holdings, Inc. Portable apparatus for peritoneal dialysis therapy
US20100089807A1 (en) 2006-05-08 2010-04-15 Keith James Heyes Dialysis machine
AU2006245567A1 (en) * 2005-05-06 2006-11-16 Imi Vision Limited Dialysis machine
EP1728526B1 (en) * 2005-06-03 2012-12-26 Fresenius Medical Care Deutschland GmbH System for monitoring the pressure in a blood line and a device to be used with such a system
US8197231B2 (en) 2005-07-13 2012-06-12 Purity Solutions Llc Diaphragm pump and related methods
US7871391B2 (en) * 2005-10-21 2011-01-18 Fresenius Medical Care Holdings, Inc. Extracorporeal fluid circuit
US20070248477A1 (en) 2006-03-29 2007-10-25 Alcon, Inc. Cassette having elastomeric clamping ribs
US8366316B2 (en) 2006-04-14 2013-02-05 Deka Products Limited Partnership Sensor apparatus systems, devices and methods
US20140199193A1 (en) 2007-02-27 2014-07-17 Deka Products Limited Partnership Blood treatment systems and methods
US20080058697A1 (en) 2006-04-14 2008-03-06 Deka Products Limited Partnership Heat exchange systems, devices and methods
US10537671B2 (en) 2006-04-14 2020-01-21 Deka Products Limited Partnership Automated control mechanisms in a hemodialysis apparatus
US8926550B2 (en) * 2006-08-31 2015-01-06 Fresenius Medical Care Holdings, Inc. Data communication system for peritoneal dialysis machine
US8870811B2 (en) 2006-08-31 2014-10-28 Fresenius Medical Care Holdings, Inc. Peritoneal dialysis systems and related methods
IL186314A (en) 2006-09-26 2011-09-27 Alcon Inc Valve that is normally closed in the free state
CA2667471C (en) * 2006-10-30 2012-01-03 Gambro Lundia Ab An extracorporeal blood chamber
US8708943B2 (en) * 2006-10-30 2014-04-29 Gambro Lundia Ab Hemo(dia) filtration apparatus
WO2008053261A1 (en) * 2006-10-30 2008-05-08 Gambro Lundia Ab Air separator for extracorporeal fluid treatment sets
CA2681912C (en) 2007-02-27 2015-09-29 Deka Products Limited Partnership Hemodialysis systems and methods
US9028691B2 (en) 2007-02-27 2015-05-12 Deka Products Limited Partnership Blood circuit assembly for a hemodialysis system
US8491184B2 (en) 2007-02-27 2013-07-23 Deka Products Limited Partnership Sensor apparatus systems, devices and methods
US10463774B2 (en) 2007-02-27 2019-11-05 Deka Products Limited Partnership Control systems and methods for blood or fluid handling medical devices
US20090107335A1 (en) 2007-02-27 2009-04-30 Deka Products Limited Partnership Air trap for a medical infusion device
US8425471B2 (en) 2007-02-27 2013-04-23 Deka Products Limited Partnership Reagent supply for a hemodialysis system
US8562834B2 (en) 2007-02-27 2013-10-22 Deka Products Limited Partnership Modular assembly for a portable hemodialysis system
US8357298B2 (en) * 2007-02-27 2013-01-22 Deka Products Limited Partnership Hemodialysis systems and methods
US8409441B2 (en) 2007-02-27 2013-04-02 Deka Products Limited Partnership Blood treatment systems and methods
US8393690B2 (en) * 2007-02-27 2013-03-12 Deka Products Limited Partnership Enclosure for a portable hemodialysis system
US8042563B2 (en) 2007-02-27 2011-10-25 Deka Products Limited Partnership Cassette system integrated apparatus
US8317492B2 (en) 2007-02-27 2012-11-27 Deka Products Limited Partnership Pumping cassette
GB0708758D0 (en) * 2007-05-04 2007-06-13 Powderject Res Ltd Particle cassettes and process thereof
AU2008260230B2 (en) 2007-05-29 2013-09-19 Fresenius Medical Care Holdings, Inc. Solutions, dialysates, and related methods
US8057423B2 (en) * 2007-07-05 2011-11-15 Baxter International Inc. Dialysis system having disposable cassette
DE102007031722B4 (en) * 2007-07-06 2011-06-16 Carl Zeiss Surgical Gmbh Device for reducing pressure fluctuations in an aspiration branch and surgical system
US8597505B2 (en) 2007-09-13 2013-12-03 Fresenius Medical Care Holdings, Inc. Portable dialysis machine
US8105487B2 (en) 2007-09-25 2012-01-31 Fresenius Medical Care Holdings, Inc. Manifolds for use in conducting dialysis
US9358331B2 (en) 2007-09-13 2016-06-07 Fresenius Medical Care Holdings, Inc. Portable dialysis machine with improved reservoir heating system
US8240636B2 (en) 2009-01-12 2012-08-14 Fresenius Medical Care Holdings, Inc. Valve system
US9308307B2 (en) 2007-09-13 2016-04-12 Fresenius Medical Care Holdings, Inc. Manifold diaphragms
JP5372938B2 (en) * 2007-09-19 2013-12-18 フレゼニウス メディカル ケア ホールディングス インコーポレーテッド Dialysis system and related parts
MX341535B (en) 2007-09-19 2016-08-24 Fresenius Medical Care Holdings Inc Safety vent structure for extracorporeal circuit.
US8038886B2 (en) * 2007-09-19 2011-10-18 Fresenius Medical Care North America Medical hemodialysis container including a self sealing vent
US7892197B2 (en) 2007-09-19 2011-02-22 Fresenius Medical Care Holdings, Inc. Automatic prime of an extracorporeal blood circuit
US8771508B2 (en) 2008-08-27 2014-07-08 Deka Products Limited Partnership Dialyzer cartridge mounting arrangement for a hemodialysis system
AU2013204659B2 (en) * 2007-10-12 2015-10-29 Deka Products Limited Partnership Apparatus and Methods for Hemodialysis
EP2246080B1 (en) 2007-10-12 2016-02-10 DEKA Products Limited Partnership An extracorporeal blood flow system
KR101573948B1 (en) * 2007-10-12 2015-12-02 데카 프로덕츠 리미티드 파트너쉽 Apparatus and method for hemodialysis
US8114276B2 (en) 2007-10-24 2012-02-14 Baxter International Inc. Personal hemodialysis system
US7905853B2 (en) 2007-10-30 2011-03-15 Baxter International Inc. Dialysis system having integrated pneumatic manifold
CA2960103C (en) 2007-11-29 2020-03-10 Fredenius Medical Care Holdings, Inc. System and method for conducting hemodialysis and hemofiltration
US10195330B2 (en) 2008-01-23 2019-02-05 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US11833281B2 (en) 2008-01-23 2023-12-05 Deka Products Limited Partnership Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
US9078971B2 (en) 2008-01-23 2015-07-14 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US11975128B2 (en) 2008-01-23 2024-05-07 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US8708950B2 (en) 2010-07-07 2014-04-29 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
CA3017406C (en) 2008-01-23 2023-08-22 Deka Products Limited Partnership Fluid handling cassette for use with a peritoneal dialysis system
US10201647B2 (en) 2008-01-23 2019-02-12 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US8961448B2 (en) * 2008-01-28 2015-02-24 Peter Forsell Implantable drainage device
US10089443B2 (en) 2012-05-15 2018-10-02 Baxter International Inc. Home medical device systems and methods for therapy prescription and tracking, servicing and inventory
USD639930S1 (en) * 2008-08-27 2011-06-14 Deka Products Limited Partnership Enclosure for a portable hemodialysis system
AU2009302327C1 (en) 2008-10-07 2015-09-10 Fresenius Medical Care Holdings, Inc. Priming system and method for dialysis systems
US8485999B2 (en) * 2008-10-14 2013-07-16 Gambro Lundia Ab Blood treatment apparatus and method
MX347636B (en) 2008-10-30 2017-04-03 Fresenius Medical Care Holdings Inc Modular, portable dialysis system.
CA2741725C (en) * 2008-12-12 2016-11-08 Fresenius Medical Care Deutschland Gmbh Apparatus for the treatment of a medical liquid and method for checking its leak tightness
FR2941385B1 (en) * 2009-01-23 2011-04-01 Millipore Corp METHOD FOR PROVIDING A CIRCUIT FOR BIOLOGICAL LIQUID AND CIRCUIT OBTAINED
US8663463B2 (en) * 2009-02-18 2014-03-04 Fresenius Medical Care Holdings, Inc. Extracorporeal fluid circuit and related components
DE102009012632A1 (en) * 2009-03-10 2010-09-23 Fresenius Medical Care Deutschland Gmbh A sealing device for sealing a volume of a medical treatment arrangement against another volume and arrangement and method
US8192401B2 (en) 2009-03-20 2012-06-05 Fresenius Medical Care Holdings, Inc. Medical fluid pump systems and related components and methods
WO2010114932A1 (en) 2009-03-31 2010-10-07 Xcorporeal, Inc. Modular reservoir assembly for a hemodialysis and hemofiltration system
DE102009024467B4 (en) * 2009-06-10 2015-12-31 Fresenius Medical Care Deutschland Gmbh Device and external functional device and treatment device for the treatment of medical fluids
HUE029690T2 (en) * 2009-04-23 2017-03-28 Fresenius Medical Care Deutschland Gmbh Air separator, external functional device, blood circulatory system and treatment device
DE102009024465B4 (en) * 2009-06-10 2015-03-05 Fresenius Medical Care Deutschland Gmbh Blood cassette with air separator, blood circulation and treatment device
DE102009024575A1 (en) * 2009-04-23 2010-12-23 Fresenius Medical Care Deutschland Gmbh Connection mechanism for use in e.g. peritoneal dialysis device for extracorporeal blood treatment in medical and laboratory technology, has pre-centering device provided for alignment of tubular pieces, which are connected with each other
EP2421583B1 (en) 2009-04-23 2020-05-27 Fresenius Medical Care Deutschland GmbH Device, external functional device and treatment device for treating medical fluids
EA022698B1 (en) * 2009-04-23 2016-02-29 Фрезениус Медикел Кеэ Дойчланд Гмбх Blood treatment cassette
WO2010121740A1 (en) 2009-04-23 2010-10-28 Fresenius Medical Care Deutschland Gmbh Receiving apparatus for receiving medical fluids and external functional apparatus and medical treatment device
CN102652843B (en) * 2009-07-01 2015-09-30 弗雷塞尼斯医疗保健控股公司 Delivery device and related system and method
US8720913B2 (en) * 2009-08-11 2014-05-13 Fresenius Medical Care Holdings, Inc. Portable peritoneal dialysis carts and related systems
DE102009045095C5 (en) * 2009-09-29 2019-04-18 Fresenius Medical Care Deutschland Gmbh Housing with flap
US9020827B2 (en) 2009-10-16 2015-04-28 Baxter International Inc. Peritoneal dialysis optimized using a patient hand-held scanning device
US9168332B2 (en) 2009-10-23 2015-10-27 Asahi Kasei Medical Co., Ltd. Hemodialysis apparatus, method of operating hemodialysis apparatus, and water content removal system
MX2012005088A (en) 2009-10-30 2012-10-03 Deka Products Lp Apparatus and method for detecting disconnection of an intravascular access device.
US8500994B2 (en) * 2010-01-07 2013-08-06 Fresenius Medical Care Holdings, Inc. Dialysis systems and methods
US9220832B2 (en) 2010-01-07 2015-12-29 Fresenius Medical Care Holdings, Inc. Dialysis systems and methods
FR2955119B1 (en) 2010-01-13 2012-12-28 Millipore Corp CIRCUIT FOR BIOLOGICAL LIQUID
US8322091B2 (en) * 2010-02-09 2012-12-04 Atwood Mobile Products, Llc Window frame assembly with integral seals
DE102010007464B4 (en) * 2010-02-10 2016-09-29 Fresenius Medical Care Deutschland Gmbh Medical functional device, treatment device and method
US8425780B2 (en) * 2010-03-11 2013-04-23 Fresenius Medical Care Holdings, Inc. Dialysis system venting devices and related systems and methods
DE102010003642A1 (en) 2010-03-15 2011-09-15 Fresenius Medical Care Deutschland Gmbh Cassette with a sensor for determining the difference between a first and a second liquid flow
DE102010012050B4 (en) 2010-03-19 2016-09-29 Fresenius Medical Care Deutschland Gmbh hemodialysis
IT1399646B1 (en) * 2010-04-21 2013-04-26 Rand Srl FILTRATION AND PUMPING SYSTEM FOR MEDICAL USE
IT1400365B1 (en) 2010-06-07 2013-05-31 Hemodec S R L EQUIPMENT FOR BLOOD TREATMENT
FR2960795B1 (en) * 2010-06-08 2012-07-27 Millipore Corp DEVICE FOR A PLANT FOR TREATING BIOLOGICAL LIQUID
FR2960794B1 (en) 2010-06-08 2012-07-27 Millipore Corp DEVICE FOR A PLANT FOR TREATING BIOLOGICAL LIQUID
FR2960796B1 (en) 2010-06-08 2014-01-24 Millipore Corp DEVICE FOR A PLANT FOR TREATING BIOLOGICAL LIQUID
FR2961713B1 (en) * 2010-06-23 2012-08-10 Millipore Corp POCKET FOR CIRCUIT OF A BIOLOGICAL LIQUID TREATMENT FACILITY
FR2961711B1 (en) 2010-06-23 2012-08-17 Millipore Corp POCKET FOR CIRCUIT OF A BIOLOGICAL LIQUID TREATMENT FACILITY
DE102010025516A1 (en) * 2010-06-29 2011-12-29 Fresenius Medical Care Deutschland Gmbh Medical functional device, process fluid and medical treatment device
DE102010032182B4 (en) * 2010-07-23 2016-09-29 Fresenius Medical Care Deutschland Gmbh Purge line, medical device function, medical treatment device and method
FR2963573B1 (en) 2010-08-03 2012-08-31 Millipore Corp PUMPING TROLLEY FOR A BIOLOGICAL LIQUID TREATMENT FACILITY
DE102010053973A1 (en) 2010-12-09 2012-06-14 Fresenius Medical Care Deutschland Gmbh Medical device with a heater
US8506684B2 (en) 2010-12-15 2013-08-13 Fresenius Medical Care Holdings, Inc. Gas release devices for extracorporeal fluid circuits and related methods
US9694125B2 (en) 2010-12-20 2017-07-04 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
DE102011008223B4 (en) 2011-01-10 2019-07-04 Fresenius Medical Care Deutschland Gmbh Dialysis treatment unit
CA2825524C (en) 2011-01-31 2021-03-23 Fresenius Medical Care Holdings, Inc. Preventing over-delivery of drug
CN103442744B (en) 2011-02-08 2017-02-15 弗雷塞尼斯医疗保健控股公司 Magnetic sensors and related systems and methods
US9624915B2 (en) 2011-03-09 2017-04-18 Fresenius Medical Care Holdings, Inc. Medical fluid delivery sets and related systems and methods
US9861733B2 (en) 2012-03-23 2018-01-09 Nxstage Medical Inc. Peritoneal dialysis systems, devices, and methods
AU2012230767A1 (en) 2011-03-23 2013-10-31 Nxstage Medical, Inc. Peritoneal dialysis systems, devices, and methods
FR2973396B1 (en) 2011-03-28 2013-05-10 Millipore Corp FACILITY FOR TREATING BIOLOGICAL LIQUID
SG10201604167XA (en) 2011-05-24 2016-07-28 Deka Products Lp Blood treatment systems and methods
US9999717B2 (en) 2011-05-24 2018-06-19 Deka Products Limited Partnership Systems and methods for detecting vascular access disconnection
CA3166031A1 (en) 2011-05-24 2012-11-29 Deka Products Limited Partnership Hemodialysis system
US9375524B2 (en) 2011-06-03 2016-06-28 Fresenius Medical Care Holdings, Inc. Method and arrangement for venting gases from a container having a powdered concentrate for use in hemodialysis
DE102011108784A1 (en) * 2011-07-29 2013-01-31 Fresenius Medical Care Deutschland Gmbh Method and devices for checking at least one function of a medical functional device
CN103930159B (en) 2011-09-13 2017-08-01 奎斯特医疗公司 Myocardium cardioplegic solution device and method
US9186449B2 (en) 2011-11-01 2015-11-17 Fresenius Medical Care Holdings, Inc. Dialysis machine support assemblies and related systems and methods
EP3002989B1 (en) 2011-11-04 2017-04-19 DEKA Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US9700457B2 (en) * 2012-03-17 2017-07-11 Abbott Medical Optics Inc. Surgical cassette
US9144646B2 (en) 2012-04-25 2015-09-29 Fresenius Medical Care Holdings, Inc. Vial spiking devices and related assemblies and methods
ES2631579T5 (en) 2012-05-22 2021-05-07 D Med Consulting Gmbh Hemodialysis machine
US9500188B2 (en) 2012-06-11 2016-11-22 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
FR2993572B1 (en) 2012-07-23 2016-04-15 Emd Millipore Corp CIRCUIT FOR BIOLOGICAL LIQUID COMPRISING A PINCH VALVE
AU2013309502B2 (en) * 2012-08-28 2017-04-20 Fenwal, Inc. Spring-open sheeting for fluid processing cassette
USD752104S1 (en) * 2012-11-30 2016-03-22 Lg Electronics Inc. Multimedia terminal having transitional graphic user interface
USD752105S1 (en) * 2012-11-30 2016-03-22 Lg Electronics Inc. Multimedia terminal having transitional graphical user interface
US9623165B2 (en) 2012-12-13 2017-04-18 Gambro Lundia Ab Cassette for pumping a treatment solution through a dialyzer
EP2745859B1 (en) * 2012-12-19 2015-07-15 Gambro Lundia AB Disposable cassette with luer locks and method for packaging
US9201036B2 (en) 2012-12-21 2015-12-01 Fresenius Medical Care Holdings, Inc. Method and system of monitoring electrolyte levels and composition using capacitance or induction
US9713660B2 (en) 2012-12-21 2017-07-25 Alcon Research, Ltd. Cassette clamp mechanism
US9157786B2 (en) 2012-12-24 2015-10-13 Fresenius Medical Care Holdings, Inc. Load suspension and weighing system for a dialysis machine reservoir
US9561323B2 (en) 2013-03-14 2017-02-07 Fresenius Medical Care Holdings, Inc. Medical fluid cassette leak detection methods and devices
US9566377B2 (en) 2013-03-15 2017-02-14 Fresenius Medical Care Holdings, Inc. Medical fluid sensing and concentration determination in a fluid cartridge with multiple passageways, using a radio frequency device situated within a magnetic field
US9597439B2 (en) 2013-03-15 2017-03-21 Fresenius Medical Care Holdings, Inc. Medical fluid sensing and concentration determination using radio frequency energy and a magnetic field
US9713664B2 (en) 2013-03-15 2017-07-25 Fresenius Medical Care Holdings, Inc. Nuclear magnetic resonance module for a dialysis machine
US9772386B2 (en) 2013-03-15 2017-09-26 Fresenius Medical Care Holdings, Inc. Dialysis system with sample concentration determination device using magnet and radio frequency coil assemblies
US9433718B2 (en) 2013-03-15 2016-09-06 Fresenius Medical Care Holdings, Inc. Medical fluid system including radio frequency (RF) device within a magnetic assembly, and fluid cartridge body with one of multiple passageways disposed within the RF device, and specially configured cartridge gap accepting a portion of said RF device
GB201305755D0 (en) 2013-03-28 2013-05-15 Quanta Fluid Solutions Ltd Re-Use of a Hemodialysis Cartridge
GB201305758D0 (en) * 2013-03-28 2013-05-15 Quanta Fluid Solutions Ltd Blood Pump
US9433721B2 (en) 2013-06-25 2016-09-06 Fresenius Medical Care Holdings, Inc. Vial spiking assemblies and related methods
DE102013013414B3 (en) * 2013-08-09 2015-01-29 Fresenius Medical Care Deutschland Gmbh cassette module
GB201314512D0 (en) 2013-08-14 2013-09-25 Quanta Fluid Solutions Ltd Dual Haemodialysis and Haemodiafiltration blood treatment device
US10117985B2 (en) 2013-08-21 2018-11-06 Fresenius Medical Care Holdings, Inc. Determining a volume of medical fluid pumped into or out of a medical fluid cassette
DE102013014097A1 (en) * 2013-08-23 2015-02-26 Fresenius Medical Care Deutschland Gmbh Disposable articles for dialysis treatment, dialysis machine and a water treatment system for dialysate
CN104548234B (en) * 2013-10-11 2017-05-24 旭化成医疗株式会社 Liquid loop
US9354640B2 (en) 2013-11-11 2016-05-31 Fresenius Medical Care Holdings, Inc. Smart actuator for valve
USD751606S1 (en) * 2013-12-30 2016-03-15 Beijing Qihoo Technology Co., Ltd. Display screen with animated graphical user interface
DE102014002578A1 (en) * 2014-02-26 2015-08-27 Fresenius Medical Care Deutschland Gmbh Medical fluid cartridge and medical tubing set with medical fluid cartridge
DE102014102598A1 (en) 2014-02-27 2015-08-27 Fresenius Medical Care Deutschland Gmbh Blood treatment cassette with sterilization opening and associated closure and blood treatment device
DE102014103491A1 (en) 2014-03-14 2015-09-17 Fresenius Medical Care Deutschland Gmbh Blood treatment cassette with foil valve and inelastic spacer as well as blood treatment device
DE102014103490A1 (en) * 2014-03-14 2015-09-17 Fresenius Medical Care Deutschland Gmbh Blood treatment cassette with foil valve and elastic spacer as well as blood treatment device
DE102014103507A1 (en) 2014-03-14 2015-09-17 Fresenius Medical Care Deutschland Gmbh Medical functional device with a valve seat for a remanentes check valve
DE102014103506A1 (en) 2014-03-14 2015-09-17 Fresenius Medical Care Deutschland Gmbh Blood treatment cassette with dished foil valve and blood treatment device
DE102014103492A1 (en) * 2014-03-14 2015-09-17 Fresenius Medical Care Deutschland Gmbh Fluid cartridge with tilt-tolerant centering latch and blood treatment device
DE102014103508B4 (en) * 2014-03-14 2019-04-18 Fresenius Medical Care Deutschland Gmbh Tensioned valve for medical functional device, and medical functional device
RU2635143C1 (en) 2014-03-17 2017-11-09 Фрезениус Медикал Кеа Холдингс, Инк. Cartridges which can be used in purification solutions for dialysis
US10286135B2 (en) 2014-03-28 2019-05-14 Fresenius Medical Care Holdings, Inc. Measuring conductivity of a medical fluid
EP3086825B1 (en) 2014-05-15 2020-09-02 novalung GmbH Medical measuring system and method for the production of the measurement system
US10391227B2 (en) * 2014-05-15 2019-08-27 Novalung Gmbh Medico-technical measuring device and measuring method
US12026271B2 (en) 2014-05-27 2024-07-02 Deka Products Limited Partnership Control systems and methods for blood or fluid handling medical devices
GB201409796D0 (en) 2014-06-02 2014-07-16 Quanta Fluid Solutions Ltd Method of heat sanitization of a haemodialysis water circuit using a calculated dose
DE102014008367A1 (en) * 2014-06-04 2015-12-17 Fresenius Medical Care Deutschland Gmbh dialysis machine
JP6783147B2 (en) 2014-06-05 2020-11-11 デカ・プロダクツ・リミテッド・パートナーシップ A system that calculates changes in fluid volume in a pumping chamber
JP6535958B2 (en) * 2014-07-07 2019-07-03 国立大学法人 東京大学 Valve, fluid device, fluid control method, and valve manufacturing method
US10589008B2 (en) 2014-08-29 2020-03-17 Fresenius Kabi Deutschland Gmbh Tubing set for use in a blood processing apparatus
WO2016030147A1 (en) * 2014-08-29 2016-03-03 Fresenius Kabi Deutschland Gmbh A blood processing apparatus comprising a holder device for a measurement device
CN106794289B (en) * 2014-08-29 2019-07-12 费森尤斯卡比德国有限公司 Blood processing apparatus including measuring device
ES2896272T3 (en) * 2014-09-22 2022-02-24 Becton Dickinson Co Plate with integral fluid path channels
WO2016096241A1 (en) * 2014-12-18 2016-06-23 Gambro Lundia Ab Method of displaying a predicted state, medical apparatus and computer program
USD773036S1 (en) * 2015-03-02 2016-11-29 Region Nordjylland, Aalborg Universitetshospital Oxygen mask
DE102015103937A1 (en) * 2015-03-17 2016-09-22 B. Braun Avitum Ag Blood treatment device with separate door compartment
US10300219B2 (en) 2015-05-26 2019-05-28 Carefusion 2200, Inc. Air in-line sensing system for IV infusion lines
US9974942B2 (en) 2015-06-19 2018-05-22 Fresenius Medical Care Holdings, Inc. Non-vented vial drug delivery
CN108025125B (en) 2015-09-16 2021-05-07 弗雷塞尼斯医疗保健控股公司 Cartridge usable in the purification of dialysis solutions
EP3159026A1 (en) 2015-10-23 2017-04-26 novalung GmbH Intermediate element for a medical extracorporeal fluid conduit, medical extracorporeal fluid system and method for measuring a gas contained in a fluid guided in a medical extracorporeal fluid system of the human or animal body
GB2543801A (en) 2015-10-28 2017-05-03 Quanta Fluid Solutions Ltd Dialysis machine and ultrafiltration
US9945838B2 (en) 2015-12-17 2018-04-17 Fresenius Medical Care Holdings, Inc. Extracorporeal circuit blood chamber having an integrated deaeration device
GB201523104D0 (en) 2015-12-30 2016-02-10 Quanta Fluid Solutions Ltd Dialysis machine
US9962477B2 (en) 2015-12-30 2018-05-08 Fresenius Medical Care Holdings, Inc. Cartridge systems useful in cleaning dialysis solutions
US11964083B2 (en) * 2016-02-18 2024-04-23 Nikkiso Co., Ltd. Extracorporeal circulation cassette
DE102016109340B4 (en) 2016-05-20 2024-01-04 Fresenius Medical Care Deutschland Gmbh Medical condensate trap for medical use, method of dehumidification, blood treatment device, blood treatment device
DE102017210134A1 (en) 2016-12-15 2018-06-21 Fresenius Medical Care Deutschland Gmbh Extracorporeal blood treatment system, treatment device, kit and method for operating an extracorporeal blood treatment system
GB201622119D0 (en) 2016-12-23 2017-02-08 Quanta Dialysis Tech Ltd Improved valve leak detection system
DE102017101730A1 (en) 2017-01-30 2018-08-02 Fresenius Medical Care Deutschland Gmbh New shock protection device for medical fluid-carrying cassette and cassette
GB201701740D0 (en) 2017-02-02 2017-03-22 Quanta Dialysis Tech Ltd Phased convective operation
GB201703048D0 (en) 2017-02-24 2017-04-12 Quanta Dialysis Tech Ltd Testing rotor engagement of a rotary peristaltic pump
DE102017106404A1 (en) * 2017-03-24 2018-09-27 Fresenius Medical Care Deutschland Gmbh Device having a device for determining a, in particular geometric, property of the device
US11135345B2 (en) 2017-05-10 2021-10-05 Fresenius Medical Care Holdings, Inc. On demand dialysate mixing using concentrates
US11179516B2 (en) 2017-06-22 2021-11-23 Baxter International Inc. Systems and methods for incorporating patient pressure into medical fluid delivery
WO2018237375A1 (en) 2017-06-24 2018-12-27 Nxstage Medical, Inc. Peritoneal dialysis fluid preparation and/or treatment devices methods and systems
USD907211S1 (en) 2017-09-28 2021-01-05 Quanta Dialysis Technologies Ltd. Dialysis machine
US11872337B2 (en) 2018-02-28 2024-01-16 Nxstage Medical, Inc. Fluid preparation and treatment devices methods and systems
CN116464623A (en) 2018-03-30 2023-07-21 德卡产品有限公司 Liquid pumping cartridge and associated pressure distribution manifold and related methods
US10918828B2 (en) * 2018-05-14 2021-02-16 Fresenius Medical Care Holdings, Inc. Kink and compression tolerant medical tubing
US20200040323A1 (en) 2018-07-31 2020-02-06 Fresenius Medical Care Holdings, Inc. Urease Purification And Purified Urease Products Thereof And Sorbent Cartridges, Systems And Methods Using The Same
US11504458B2 (en) 2018-10-17 2022-11-22 Fresenius Medical Care Holdings, Inc. Ultrasonic authentication for dialysis
EP3666310B1 (en) * 2018-12-13 2022-03-16 Fenwal, Inc. Cassette plate of cassette holder of medical device and tool-free methods of installing and removing the same
CN110338970B (en) * 2019-07-23 2024-02-02 以诺康医疗科技(苏州)有限公司 Ultrasonic emulsification handle with sensor and surge control system and method
ES2884853T3 (en) 2019-08-19 2021-12-13 Gambro Lundia Ab Method of priming an extracorporeal blood circuit of an apparatus for the treatment of extracorporeal blood and an apparatus for the treatment of extracorporeal blood
EP4048337A1 (en) * 2019-10-25 2022-08-31 IBD Italian Biomedical Devices S.r.l. Manifold for dialysis machines and equipment and dialysis machine or equipment comprising said manifold
CA3160853A1 (en) 2019-11-12 2021-05-20 Fresenius Medical Care Deutschland Gmbh Blood treatment systems
WO2021094144A1 (en) 2019-11-12 2021-05-20 Fresenius Medical Care Deutschland Gmbh Blood treatment systems
WO2021094139A1 (en) 2019-11-12 2021-05-20 Fresenius Medical Care Deutschland Gmbh Blood treatment systems
WO2021096706A1 (en) 2019-11-12 2021-05-20 Fresenius Medical Care Deutschland Gmbh Blood treatment systems
US11759560B2 (en) * 2020-09-15 2023-09-19 Fresenius Medical Care Holdings, Inc. Safety mechanism for a dialysis system
DE102020211553A1 (en) 2020-09-15 2022-03-17 B.Braun Avitum Ag Medical Fluid Pump System
USD1008463S1 (en) * 2020-10-06 2023-12-19 Byonyks Medical Devices, Inc. Multiple pressure sensing system for peritoneal dialysis
CN114534014A (en) * 2020-11-18 2022-05-27 感知医疗公司 System for regulating patient infusion and assembly thereof
EP4186556A1 (en) * 2021-11-25 2023-05-31 Medtron AG High pressure medical injector
CN114452211B (en) * 2022-01-28 2023-10-03 深圳泰和智能医疗科技有限公司 Dispensing filter and dispensing method thereof
WO2023159584A1 (en) * 2022-02-28 2023-08-31 Fresenius Medical Care Deutschland Gmbh Hydraulic block for dialysis, hydraulic system for dialysis and method for manufacturing hydraulic block

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378126A (en) * 1992-12-30 1995-01-03 Abbott Laboratories Diaphragm cassette for solution pumping system

Family Cites Families (497)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US100882A (en) * 1870-03-15 Improvement in combined carriage, cradle, swing, and baby-walker
US329773A (en) 1885-11-03 perry
US62109A (en) * 1867-02-19 Jambs armstrong
US84647A (en) * 1868-12-01 Improved last-block elevator and instep-stretcher
US42181A (en) * 1864-04-05 Improvement in bee-hives
US577537A (en) * 1897-02-23 Farm-gate
US6241704B1 (en) 1901-11-22 2001-06-05 Sims Deltec, Inc. Drug pump systems and methods
US5935099A (en) 1992-09-09 1999-08-10 Sims Deltec, Inc. Drug pump systems and methods
US2383193A (en) 1943-11-01 1945-08-21 Oliver United Felters Inc Diaphragm pump
US2453590A (en) 1946-11-04 1948-11-09 Noel J Poux Hypodermic syringe
US2529028A (en) 1947-07-31 1950-11-07 Landon Standard Pools Chemical feeder
US2658526A (en) 1948-04-23 1953-11-10 Chefford Master Mfg Co Inc Diaphragm for pumps
US2711134A (en) 1950-07-26 1955-06-21 Infilco Inc Chemical feeder
US2755745A (en) 1951-05-28 1956-07-24 Harold L Lewis Self watering container
US2871795A (en) 1956-02-29 1959-02-03 American Viscose Corp Double acting diaphragm pump
US2886281A (en) 1957-03-05 1959-05-12 Otis Eng Co Control valve
US3083943A (en) 1959-07-06 1963-04-02 Anbrey P Stewart Jr Diaphragm-type valve
GB1096644A (en) 1964-05-06 1967-12-29 Applic Gomma Anti Vibranti S A Resilient suspension system, more particularly for motor vehicles
US3556465A (en) 1969-06-09 1971-01-19 Rkl Controls Diaphragm valve assembly and method of making same
GB1311901A (en) 1970-04-15 1973-03-28 Bertil Nystroem Ernst Holger Membrane pump
DE2019345C3 (en) 1970-04-22 1982-12-09 Voith Getriebe Kg, 7920 Heidenheim Arrangement for influencing the excitation current of a direct current electromagnet used as a drive for solenoid valves
DE2023858A1 (en) 1970-05-15 1971-12-02 Daimler Benz Ag
US3689025A (en) 1970-07-30 1972-09-05 Elmer P Kiser Air loaded valve
US4370983A (en) 1971-01-20 1983-02-01 Lichtenstein Eric Stefan Computer-control medical care system
US6189857B1 (en) 1971-04-13 2001-02-20 The United States Of America As Represented By The United States Department Of Energy Fluid-actuated rapid closure valve
US3781141A (en) 1971-07-12 1973-12-25 Dorr Oliver Inc Air pressure actuated single-acting diaphragm pump
US3927955A (en) 1971-08-23 1975-12-23 East West Medical Products Inc Medical cassette pump
DE2355966A1 (en) 1973-11-09 1975-05-22 Medac Klinische Spezialpraep PUMP ARRANGEMENT, ESPECIALLY FOR BLOOD PUMPS
US3880053A (en) 1974-05-31 1975-04-29 Tl Systems Corp Pump
US4158530A (en) 1974-07-01 1979-06-19 Bernstein Robert E Pumping apparatus comprising two collapsible chambers
US3996027A (en) 1974-10-31 1976-12-07 Baxter Laboratories, Inc. Swirling flow bubble trap
US3985135A (en) 1975-03-31 1976-10-12 Baxter Laboratories, Inc. Dual chamber reservoir
US4026669A (en) 1975-07-14 1977-05-31 Baxter Laboratories, Inc. Variable capacity reservoir assembly
ZA756215B (en) 1975-09-30 1977-01-26 Wynns Car Care Prod Flushing of liquid circulation systems
US4047844A (en) 1975-12-08 1977-09-13 Searle Cardio-Pulmonary Systems Inc. Blood pumping system
GB1483702A (en) 1976-01-14 1977-08-24 Instr Constr & Maintenance Ltd Fluid valve
US4091812A (en) 1976-01-19 1978-05-30 Alcon Laboratories, Inc. Operator means for syringe cartridges
DE2628238A1 (en) 1976-06-24 1978-01-05 Gerhard Dr Ing Kunz Valve for maintaining constant back pressure - has pressure actuated diaphragm separating supply pressure chamber and feed chamber
US4050859A (en) 1976-07-01 1977-09-27 Graco Inc. Diaphragm pump having a reed valve barrier to hydraulic shock in the pressurizing fluid
US4121584A (en) 1976-10-15 1978-10-24 R. Scott Turner Method and apparatus for controlling the dispensing of fluid
US4152098A (en) 1977-01-03 1979-05-01 Clark Ivan P Micropump
US4436620A (en) * 1977-05-09 1984-03-13 Baxter Travenol Laboratories, Inc. Integral hydraulic circuit for hemodialysis apparatus
CA1104032A (en) * 1977-05-09 1981-06-30 Marc Bellotti Integral hydraulic circuit for hemodialysis apparatus
US4333452A (en) 1977-06-24 1982-06-08 Au Anthony S Pressure control systems
US4178940A (en) 1977-06-24 1979-12-18 Au Anthony S Pressure control systems
US4273121A (en) 1978-02-17 1981-06-16 Andros Incorporated Medical infusion system
US4322201A (en) 1979-03-09 1982-03-30 Avi, Inc. IV Pump with back pressure control
US4410322A (en) 1979-03-09 1983-10-18 Avi, Inc. Nonpulsating TV pump and disposable pump chamber
US4382753A (en) 1979-03-09 1983-05-10 Avi, Inc. Nonpulsating IV pump and disposable pump chamber
US4263808A (en) * 1979-03-26 1981-04-28 Baxter Travenol Laboratories, Inc. Noninvasive pressure monitor
US4303376A (en) 1979-07-09 1981-12-01 Baxter Travenol Laboratories, Inc. Flow metering cassette and controller
US4304260A (en) 1979-11-01 1981-12-08 Turner Charles R Flexible diaphragm valve device
US4368118A (en) 1980-01-07 1983-01-11 Siposs George G Blood-air separator and filter
US4312344A (en) 1980-04-03 1982-01-26 Kenova Ab Syringe
US4453932A (en) 1980-08-01 1984-06-12 Oximetrix, Inc. Intravenous metering device
US4345919A (en) 1981-01-19 1982-08-24 Texas Medical Products, Inc. Degasser for biological fluids
US4412916A (en) * 1981-06-24 1983-11-01 Cordis Dow Corp. Airless artificial kidney assembly
US4411603A (en) 1981-06-24 1983-10-25 Cordis Dow Corp. Diaphragm type blood pump for medical use
US4412553A (en) 1981-06-25 1983-11-01 Baxter Travenol Laboratories, Inc. Device to control the transmembrane pressure in a plasmapheresis system
JPS58178879A (en) 1982-04-14 1983-10-19 Muroran Kogyo Daigaku Wave power generating method and device
US4703913A (en) 1982-09-22 1987-11-03 California Institute Of Technology Diaphragm valve
US4597412A (en) 1982-09-29 1986-07-01 Stark Anton W Valve for sequential chemical operations
US4662598A (en) 1982-12-02 1987-05-05 Bermad Kibbutz Evron Sleeve valve with integral control chamber
US4569378A (en) 1982-12-13 1986-02-11 National Instrument Company Inc. Filling machine with tandem-operated diaphragm filling units
US4479762A (en) * 1982-12-28 1984-10-30 Baxter Travenol Laboratories, Inc. Prepackaged fluid processing module having pump and valve elements operable in response to applied pressures
US4479761A (en) 1982-12-28 1984-10-30 Baxter Travenol Laboratories, Inc. Actuator apparatus for a prepackaged fluid processing module having pump and valve elements operable in response to externally applied pressures
EP0129554B1 (en) 1982-12-28 1988-12-07 BAXTER INTERNATIONAL INC. (a Delaware corporation) Prepackaged fluid processing module having pump and valve elements operable in response to applied pressures
US4479760A (en) 1982-12-28 1984-10-30 Baxter Travenol Laboratories, Inc. Actuator apparatus for a prepackaged fluid processing module having pump and valve elements operable in response to applied pressures
JPS59228849A (en) 1983-06-10 1984-12-22 テルモ株式会社 Apparatus for removing air bubbles in liquid
JPS602650A (en) 1983-06-21 1985-01-08 Plus Eng Co Ltd Ejector pin having good wear resistance and toughness
SE451801B (en) * 1983-11-29 1987-11-02 Gambro Lundia Ab DEVICE FOR BREATHING A FLUID THROUGH A PIPE
US4583920A (en) 1983-12-28 1986-04-22 M&T Chemicals Inc. Positive displacement diaphragm pumps employing displacer valves
US5100380A (en) 1984-02-08 1992-03-31 Abbott Laboratories Remotely programmable infusion system
US4572724A (en) 1984-04-12 1986-02-25 Pall Corporation Blood filter
US4558715A (en) 1984-05-16 1985-12-17 Kowatachi International, Ltd. Apparatus for injecting measured quantities of liquid into a fluid stream
US4628499A (en) 1984-06-01 1986-12-09 Scientific-Atlanta, Inc. Linear servoactuator with integrated transformer position sensor
CS248305B1 (en) * 1984-06-18 1987-02-12 Miroslav Skala Blood cleaning instrument
FR2566508B1 (en) 1984-06-26 1987-01-02 Electricite De France DEVICE FOR SEALING AN OPENING AND DRAWER VALVE COMPRISING SUCH A DEVICE
DE3428828A1 (en) 1984-08-04 1986-02-13 Karl-Theo 6652 Bexbach Braun DEVICE FOR CONVEYING MECHANICAL STRESS HIGH-SENSITIVE LIQUIDS
JPS6154314A (en) 1984-08-23 1986-03-18 Kyushu Parukon:Kk Ventilation in vehicle compartment using output of solar battery
US4902282A (en) 1984-10-09 1990-02-20 Baxter Travenol Labs. Inc. Tuned cycler set
US4623328A (en) 1984-10-29 1986-11-18 Mcneilab, Inc. Pump monitor for photoactivation patient treatment system
US4643713A (en) 1984-11-05 1987-02-17 Baxter Travenol Laboratories, Inc. Venous reservoir
US4840542A (en) 1985-03-27 1989-06-20 Quest Medical, Inc. Infusion pump with direct pressure sensing
US4657490A (en) 1985-03-27 1987-04-14 Quest Medical, Inc. Infusion pump with disposable cassette
US4610605A (en) 1985-06-25 1986-09-09 Product Research And Development Triple discharge pump
US4676467A (en) 1985-10-31 1987-06-30 Cobe Laboratories, Inc. Apparatus for supporting a fluid flow cassette
US4710166A (en) 1985-11-08 1987-12-01 Quest Medical, Inc. Automated drug additive infusion system
US4639245A (en) 1985-12-20 1987-01-27 Oximetrix, Inc. Fluid infusion pump driver
US5193990A (en) 1986-03-04 1993-03-16 Deka Products Limited Partnership Fluid management system with auxiliary dispensing chamber
US4976162A (en) 1987-09-03 1990-12-11 Kamen Dean L Enhanced pressure measurement flow control system
US4778451A (en) 1986-03-04 1988-10-18 Kamen Dean L Flow control system using boyle's law
US5178182A (en) 1986-03-04 1993-01-12 Deka Products Limited Partnership Valve system with removable fluid interface
US5088515A (en) 1989-05-01 1992-02-18 Kamen Dean L Valve system with removable fluid interface
US6406276B1 (en) 1986-03-04 2002-06-18 Deka Products Limited Partnership Constant-pressure fluid supply system with multiple fluid capability
US5353837A (en) 1986-03-04 1994-10-11 Deka Products Limited Partnership Quick-disconnect valve
US4826482A (en) 1986-03-04 1989-05-02 Kamen Dean L Enhanced pressure measurement flow control system
US5116021A (en) 1986-03-04 1992-05-26 Deka Products Limited Partnership Quick-disconnect valve
US5211201A (en) 1986-03-04 1993-05-18 Deka Products Limited Partnership Intravenous fluid delivery system with air elimination
US4735558A (en) 1986-04-08 1988-04-05 Staar Surgical Company Peristaltic pump latching mechanism
US4690621A (en) 1986-04-15 1987-09-01 Advanced Control Engineering Filter pump head assembly
US4698207A (en) * 1986-07-14 1987-10-06 Baxter Travenol Laboratories, Inc. Integrated membrane oxygenator, heat exchanger and reservoir
US4784577A (en) 1986-09-02 1988-11-15 Critikon, Inc. Pump pressure sensor
JPS6395063A (en) * 1986-10-09 1988-04-26 旭メデイカル株式会社 Assembling type body fluid treatment set
US4786240A (en) 1987-02-06 1988-11-22 Applied Biotechnologies, Inc. Pumping apparatus with an electromagnet affixed to the septum
US4842584A (en) 1987-05-01 1989-06-27 Abbott Laboratories Disposable fluid infusion pumping chamber cassette and drive mechanism thereof
US4927411A (en) * 1987-05-01 1990-05-22 Abbott Laboratories Drive mechanism for disposable fluid infusion pumping cassette
IL83259A (en) 1987-07-20 1992-05-25 D F Lab Ltd Disposable cell and diaphragm pump for use of same
DE3877852T2 (en) * 1987-08-03 1993-05-19 Gelman Sciences Inc SELF-WORKING FILTER.
IL84286A (en) 1987-10-26 1992-07-15 D F Lab Ltd Diaphragm and diaphragm-actuated fluid-transfer control device
CH675216A5 (en) 1987-11-30 1990-09-14 Alphasem Ag
US4850980A (en) 1987-12-04 1989-07-25 Fisher Scientific Company I.V. pump cassette
US4858883A (en) 1987-12-11 1989-08-22 Integrated Fluidics, Inc. Valve with flexible sheet member
JPH0828722B2 (en) 1988-06-25 1996-03-21 富士通電装株式会社 Data transmission control method
GB8825816D0 (en) 1988-11-04 1988-12-07 Danby Medical Eng Ltd Pumping device
US5006050A (en) 1988-12-09 1991-04-09 James E. Cooke High accuracy disposable cassette infusion pump
US5036886A (en) 1988-12-12 1991-08-06 Olson Controls, Inc. Digital servo valve system
US4950134A (en) 1988-12-27 1990-08-21 Cybor Corporation Precision liquid dispenser
US5011380A (en) 1989-01-23 1991-04-30 University Of South Florida Magnetically actuated positive displacement pump
DE4006785A1 (en) 1989-03-03 1990-09-06 Passavant Werke Blocking control for pipeline - incorporates expanding membrane stretched under inspection hatch and inflated to seal pipe
US5167837A (en) 1989-03-28 1992-12-01 Fas-Technologies, Inc. Filtering and dispensing system with independently activated pumps in series
US5279556A (en) 1989-04-28 1994-01-18 Sharp Kabushiki Kaisha Peristaltic pump with rotary encoder
US6828125B1 (en) 1989-05-10 2004-12-07 Baxter Biotech Technology, S.A.R.L. DNA encoding fused di-alpha globins and use thereof
US5599907A (en) 1989-05-10 1997-02-04 Somatogen, Inc. Production and use of multimeric hemoglobins
IT1231308B (en) 1989-07-27 1991-11-28 Tetra Dev Co PISTON UNIT WITH ROLLING MEMBRANE
US4995864A (en) 1989-08-15 1991-02-26 Imed Corporation Dual chamber pumping apparatus
US5100699A (en) 1989-08-24 1992-03-31 Minnesota Mining And Manufacturing Company Method and apparatus for precision pumping, ratioing, and dispensing of work fluid(s)
JPH0396850A (en) 1989-09-08 1991-04-22 Fuji Electric Co Ltd Electrolytic cell for polarization measurement
US4997464A (en) 1990-03-23 1991-03-05 Kopf Henry B Deaeration apparatus
US5171029A (en) 1990-04-26 1992-12-15 Minnesota Mining And Manufacturing Company Seal construction for pump apparatus
JPH062650Y2 (en) 1990-05-29 1994-01-26 幸雄 関根 Electrode holder for electrocardiography
US5061236A (en) 1990-07-16 1991-10-29 Baxter International Inc. Venous reservoir with improved inlet configuration and integral screen for bubble removal
US5362406A (en) 1990-07-27 1994-11-08 Pall Corporation Leucocyte depleting filter device and method of use
US5713888A (en) 1990-10-31 1998-02-03 Baxter International, Inc. Tissue implant systems
JP3141395B2 (en) 1990-11-27 2001-03-05 富士ゼロックス株式会社 Recording device
US5098262A (en) 1990-12-28 1992-03-24 Abbott Laboratories Solution pumping system with compressible pump cassette
US5116316A (en) 1991-02-25 1992-05-26 Baxter International Inc. Automatic in-line reconstitution system
US6099492A (en) 1991-03-12 2000-08-08 Le Boeuf; Guy Electronic apparatus for blood transfusion
US5486286A (en) 1991-04-19 1996-01-23 Althin Medical, Inc. Apparatus for performing a self-test of kidney dialysis membrane
US5247434A (en) 1991-04-19 1993-09-21 Althin Medical, Inc. Method and apparatus for kidney dialysis
US5146713A (en) 1991-05-02 1992-09-15 American Sterilizer Company Hydraulic door operating system for autoclaves and sterilizers
JP3410481B2 (en) * 1991-07-30 2003-05-26 シャープ株式会社 Semiconductor laser device
US5249932A (en) 1991-10-07 1993-10-05 Erik Van Bork Apparatus for controlling diaphragm extension in a diaphragm metering pump
US5641892A (en) 1995-06-07 1997-06-24 Deka Products Limited Partnership Intravenous-line air-detection system
US5713865A (en) 1991-11-15 1998-02-03 Deka Products Limited Partnership Intravenous-line air-elimination system
US5772637A (en) 1995-06-07 1998-06-30 Deka Products Limited Partnership Intravenous-line flow-control system
US5755683A (en) 1995-06-07 1998-05-26 Deka Products Limited Partnership Stopcock valve
US5267956A (en) 1992-02-05 1993-12-07 Alcon Surgical, Inc. Surgical cassette
DE9201455U1 (en) 1992-02-06 1992-04-02 Fa. Andreas Stihl, 7050 Waiblingen Diaphragm fuel pump for a diaphragm carburettor
US5238003A (en) 1992-02-07 1993-08-24 Baidwan Balinderjeet S Plunger tip for blood gas syringe
US5281112A (en) 1992-02-25 1994-01-25 The Regents Of The University Of Michigan Self regulating blood pump with controlled suction
US5431634A (en) 1992-03-06 1995-07-11 Baxter International Inc. Ambulatory pump
US5328461A (en) 1992-04-30 1994-07-12 Utterberg David S Blow molded venous drip chamber for hemodialysis
CA2094102A1 (en) 1992-04-30 1993-10-31 David S. Utterberg Blood air trap chamber
US5578070A (en) 1992-04-30 1996-11-26 Medisystems Technology Corporation Blow molded venous drip chamber for hemodialysis
US5554013A (en) 1992-05-01 1996-09-10 Mcgaw, Inc. Disposable cassette with negative head height fluid supply
US5302093A (en) 1992-05-01 1994-04-12 Mcgaw, Inc. Disposable cassette with negative head height fluid supply and method
JP2578759Y2 (en) 1992-06-15 1998-08-13 ティーディーケイ株式会社 Transformer core
JPH062650A (en) 1992-06-16 1994-01-11 F D K Eng:Kk Measuring pumping device
US5344292A (en) 1992-08-20 1994-09-06 Ryder International Corporation Fluid pumping system and apparatus
US5252044A (en) 1992-10-20 1993-10-12 Medflow, Inc. Parenteral fluid pump with disposable cassette
JPH06154314A (en) 1992-11-17 1994-06-03 Nikkiso Co Ltd Automatic peritoneal-dialysis apparatus
DE4336336A1 (en) 1992-11-23 1994-05-26 Lang Volker Cassette infusion system
AU5747894A (en) 1992-12-18 1994-07-19 Abbott Laboratories Solution pumping system for maximizing output while minimizing pumping pressures
DE4243759C1 (en) 1992-12-23 1994-01-20 Norddeutsche Affinerie Wet scrubbing of gas - by pre-scrubbing and then accelerating gas prior to cyclone sepn. of clean gas
CH685461B5 (en) 1993-01-05 1996-01-31 Jean Claude Berney liquid substances therapeutic infusion sets and portable device comprising such a device.
US5840151A (en) 1993-02-04 1998-11-24 Baxter International Inc. Apparatus and dies for forming peelable tube assemblies
US5441636A (en) 1993-02-12 1995-08-15 Cobe Laboratories, Inc. Integrated blood treatment fluid module
US5540808A (en) * 1993-02-24 1996-07-30 Deka Products Limited Partnership Energy director for ultrasonic welding and joint produced thereby
US5350357A (en) 1993-03-03 1994-09-27 Deka Products Limited Partnership Peritoneal dialysis systems employing a liquid distribution and pumping cassette that emulates gravity flow
US5474683A (en) * 1993-03-03 1995-12-12 Deka Products Limited Partnership Peritoneal dialysis systems and methods employing pneumatic pressure and temperature-corrected liquid volume measurements
US5324422A (en) 1993-03-03 1994-06-28 Baxter International Inc. User interface for automated peritoneal dialysis systems
WO1994020154A1 (en) * 1993-03-03 1994-09-15 Deka Products Limited Partnership Peritoneal dialysis systems and methods employing a liquid distribution and pump cassette with self-contained air isolation and removal
USD351470S (en) 1993-03-03 1994-10-11 Baxter International Inc. Peritoneal dialysis cycler
US5438510A (en) 1993-03-03 1995-08-01 Deka Products Limited Partnership User interface and monitoring functions for automated peritoneal dialysis systems
US5431626A (en) 1993-03-03 1995-07-11 Deka Products Limited Partnership Liquid pumping mechanisms for peritoneal dialysis systems employing fluid pressure
DK39293D0 (en) 1993-04-01 1993-04-01 Novo Nordisk As DISPENSES PROTECTED FOR RECYCLING
US5480292A (en) 1993-05-19 1996-01-02 Asti Sae Dual chamber pump
US5385540A (en) 1993-05-26 1995-01-31 Quest Medical, Inc. Cardioplegia delivery system
US5645531A (en) 1993-05-26 1997-07-08 Quest Medical, Inc. Constant pressure blood mixture delivery system and method
CA2101232A1 (en) 1993-07-23 1995-01-24 Timothy J. Woods Process of worm farming and large scale composting which uses discarded tires as composting and worm propagation silos
US5540568A (en) 1993-07-26 1996-07-30 National Instrument Co., Inc. Disposable rolling diaphragm filling unit
EP0646380B1 (en) 1993-09-01 1997-06-25 Fresenius AG Air separator
DE4332720C2 (en) 1993-09-25 1997-02-13 Karlsruhe Forschzent Micro diaphragm pump
US5395351A (en) 1993-09-29 1995-03-07 Baxter International Inc. Self-valving connector and interface system and a method of using same
JP2718833B2 (en) 1993-10-14 1998-02-25 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー Automatic sample container handling centrifuge and rotor used for it
US5431627A (en) * 1993-11-12 1995-07-11 Abbott Laboratories Cassette identification system for use with a multi-program drug infusion pump
US5591251A (en) 1993-11-29 1997-01-07 Cobe Laboratories, Inc. Side flow bubble trap apparatus and method
US5746708A (en) 1993-12-22 1998-05-05 Baxter International Inc. Peristaltic pump tube holder with pump tube shield and cover
US5482440A (en) 1993-12-22 1996-01-09 Baxter Int Blood processing systems using a peristaltic pump module with valve and sensing station for operating a peristaltic pump tube cassette
US5514069A (en) 1993-12-22 1996-05-07 Baxter International Inc. Stress-bearing umbilicus for a compact centrifuge
US5480294A (en) 1993-12-22 1996-01-02 Baxter International Inc. Peristaltic pump module having jaws for gripping a peristaltic pump tube cassett
US5462417A (en) 1993-12-22 1995-10-31 Baxter International Inc. Peristaltic pump with linear pump roller positioning mechanism
CA2155735A1 (en) 1993-12-22 1995-06-29 Richard C. Giesler Self-priming drip chamber with enhanced visibility
US5484239A (en) 1993-12-22 1996-01-16 Baxter International Inc. Peristaltic pump and valve assembly for fluid processing systems
US5551942A (en) 1993-12-22 1996-09-03 Baxter International Inc. Centrifuge with pivot-out, easy-load processing chamber
US5445506A (en) 1993-12-22 1995-08-29 Baxter International Inc. Self loading peristaltic pump tube cassette
US5462416A (en) 1993-12-22 1995-10-31 Baxter International Inc. Peristaltic pump tube cassette for blood processing systems
CA2155641A1 (en) 1993-12-22 1995-06-29 Paul Diperna Centrifuge with sloped rotational axis and sloped control panel
US5427509A (en) 1993-12-22 1995-06-27 Baxter International Inc. Peristaltic pump tube cassette with angle pump tube connectors
US5447286A (en) 1994-01-21 1995-09-05 Deka Products Limited Partnership High flow valve
FR2715393B1 (en) 1994-01-25 1996-04-12 Saumur Ateliers Aeronautiques Method and device for transferring liquids and their use in a peritoneal dialysis system.
CA2142413A1 (en) 1994-02-15 1995-08-16 Wesley H. Verkarrt Vortex gas elimination device
US5482438A (en) 1994-03-09 1996-01-09 Anderson; Robert L. Magnetic detent and position detector for fluid pump motor
US5630710A (en) 1994-03-09 1997-05-20 Baxter International Inc. Ambulatory infusion pump
US5658133A (en) 1994-03-09 1997-08-19 Baxter International Inc. Pump chamber back pressure dissipation apparatus and method
US5478211A (en) 1994-03-09 1995-12-26 Baxter International Inc. Ambulatory infusion pump
US5482446A (en) 1994-03-09 1996-01-09 Baxter International Inc. Ambulatory infusion pump
JP3677045B2 (en) 1994-04-06 2005-07-27 バクスター、インターナショナル、インコーポレイテッド Apparatus for tidal vibration pulse peritoneal dialysis
FR2719873A1 (en) 1994-05-11 1995-11-17 Debiotech Sa Peristaltic pump device.
ATE245040T1 (en) 1994-05-13 2003-08-15 Abbott Lab DISPOSABLE INFUSION CASSETTE WITH A PUSH-BUTTON OPERATED APSOCKET VALVE
GB9409989D0 (en) 1994-05-18 1994-07-06 Huntleigh Technology Plc Magnetic actuator
US5421208A (en) 1994-05-19 1995-06-06 Baxter International Inc. Instantaneous volume measurement system and method for non-invasively measuring liquid parameters
DE4419593A1 (en) 1994-06-03 1995-12-07 Fresenius Ag Device for measuring the pressure of a medium
US5624409A (en) 1994-06-10 1997-04-29 Fluidsense Corporation Variable-pulse dynamic fluid flow controller
ES2162923T3 (en) 1994-06-17 2002-01-16 Baxter Int METHOD AND APPARATUS FOR PERITONEAL DIALYSIS OF PURPOSE IMPULSE.
US5538405A (en) 1994-07-01 1996-07-23 Baxter International Inc. Peristaltic pulse pumping systems and methods
JP3706399B2 (en) 1994-07-20 2005-10-12 クリナップ株式会社 Bubble tub equipment
US5993174A (en) 1994-08-23 1999-11-30 Nikkiso Co., Ltd. Pulsation free pump
IL115327A (en) 1994-10-07 2000-08-13 Bayer Ag Diaphragm pump
US5934885A (en) 1994-10-07 1999-08-10 Bayer Corporation Reagent pump assembly
US5593290A (en) 1994-12-22 1997-01-14 Eastman Kodak Company Micro dispensing positive displacement pump
JP2726014B2 (en) 1995-01-06 1998-03-11 株式会社ワイ・テイ・エス Diaphragm assembly and method of manufacturing the same
US5591344A (en) * 1995-02-13 1997-01-07 Aksys, Ltd. Hot water disinfection of dialysis machines, including the extracorporeal circuit thereof
US5725928A (en) 1995-02-17 1998-03-10 Velcro Industries B.V. Touch fastener with magnetic attractant
ES2143100T3 (en) 1995-02-24 2000-05-01 Fresenius Medical Care De Gmbh DEVICE FOR SEPARATING AIR BUBBLES FROM MEDICAL LIQUIDS.
US5775371A (en) 1995-03-08 1998-07-07 Abbott Laboratories Valve control
US5640995A (en) 1995-03-14 1997-06-24 Baxter International Inc. Electrofluidic standard module and custom circuit board assembly
US5799207A (en) 1995-03-28 1998-08-25 Industrial Technology Research Institute Non-blocking peripheral access architecture having a register configure to indicate a path selection for data transfer between a master, memory, and an I/O device
US7267666B1 (en) 1995-04-20 2007-09-11 Acist Medical Systems, Inc. Angiographic injector system with multiple processor redundancy
US5772635A (en) 1995-05-15 1998-06-30 Alaris Medical Systems, Inc. Automated infusion system with dose rate calculator
US5873853A (en) 1995-05-23 1999-02-23 Baxter International Inc. Portable pump apparatus for continuous ambulatory peritoneal dialysis and a method for providing same
US5769815A (en) 1995-05-25 1998-06-23 Medisystems Technology Corporation Blood chamber with integral projections
DE69636518T2 (en) 1995-06-07 2007-05-03 Gambro Inc., Lakewood EXTRACORPORAL BLOOD TREATMENT DEVICE AND METHOD FOR OPERATING SUCH A DEVICE
US6709417B1 (en) 1995-06-07 2004-03-23 Deka Products Limited Partnership Valve for intravenous-line flow-control system
US6790195B2 (en) 1995-06-07 2004-09-14 Gambro Inc Extracorporeal blood processing methods and apparatus
US5676644A (en) 1995-06-07 1997-10-14 Cobe Laboratories, Inc. Extracorporeal blood processing methods and apparatus
US5738644A (en) 1995-06-07 1998-04-14 Cobe Laboratories, Inc. Extracorporeal blood processing methods and apparatus
US5795317A (en) 1995-06-07 1998-08-18 Cobe Laboratories, Inc. Extracorporeal blood processing methods and apparatus
US6364857B1 (en) 1995-06-07 2002-04-02 Deka Products Limited Partnership Cassette for intravenous-line flow-control system
US6165154A (en) 1995-06-07 2000-12-26 Deka Products Limited Partnership Cassette for intravenous-line flow-control system
US5925011A (en) 1995-08-30 1999-07-20 Baxter International Inc. System and method for providing sterile fluids for admixed solutions in automated peritoneal dialysis
US5938634A (en) 1995-09-08 1999-08-17 Baxter International Inc. Peritoneal dialysis system with variable pressure drive
JP3035854B2 (en) 1995-09-15 2000-04-24 ハーン−シッカート−ゲゼルシャフト フア アンゲワンテ フォルシュンク アインゲトラーゲナー フェライン Fluid pump without check valve
US6071095A (en) 1995-10-20 2000-06-06 Harvest Technologies Corporation Container with integral pump platen
NL1001528C2 (en) 1995-10-30 1997-05-02 Cerato B V Dialysis device.
JPH09201412A (en) * 1996-01-26 1997-08-05 Senko Ika Kogyo Kk Apparatus for removing bubble and extracorporeal blood circulation system
GB9607471D0 (en) 1996-04-10 1996-06-12 Baxter Int Volumetric infusion pump
US5843035A (en) 1996-04-10 1998-12-01 Baxter International Inc. Air detector for intravenous infusion system
US5782805A (en) 1996-04-10 1998-07-21 Meinzer; Randolph Medical infusion pump
US5764034A (en) 1996-04-10 1998-06-09 Baxter International Inc. Battery gauge for a battery operated infusion pump
USD390654S (en) 1996-04-26 1998-02-10 Baxter International Inc. Volumetric infusion pump
DE19617036C2 (en) 1996-04-27 2003-12-04 Fresenius Ag Device for separating gas bubbles from blood
US5823747A (en) 1996-05-29 1998-10-20 Waters Investments Limited Bubble detection and recovery in a liquid pumping system
US6699966B1 (en) * 1996-07-08 2004-03-02 University Of Massachusetts Proteins within the type E botulinum neurotoxin complex
US5634391A (en) 1996-07-09 1997-06-03 Westinghouse Air Brake Co. Inert plastic coated flexible type diaphragm for application in a sanitary type pump
US6079959A (en) 1996-07-15 2000-06-27 Saint-Gobain Performance Plastics Corporation Reciprocating pump
DE19634922C2 (en) 1996-08-29 2000-03-23 Knf Neuberger Gmbh Diaphragm pump
CA2268278A1 (en) 1996-10-18 1998-04-30 Somatogen, Inc. Methods of reducing the levels of protoporphyrin ix in recombinant hemoglobin preparations
US5857589A (en) 1996-11-20 1999-01-12 Fluid Research Corporation Method and apparatus for accurately dispensing liquids and solids
US5769387A (en) 1996-11-20 1998-06-23 Perez C.; Sergio Flow valves operated by flow transfer means which regulate small flows of control
CA2272348C (en) * 1996-11-22 2007-01-23 Therakos, Inc. Integrated cassette for controlling fluid having an integral filter
EP0957954B1 (en) 1996-11-22 2003-05-28 Therakos, Inc. Apparatus for pumping fluid at a steady flow rate
US6117342A (en) 1996-11-26 2000-09-12 Medisystems Technology Corporation Bubble trap with directed horizontal flow and method of using
GB9701413D0 (en) 1997-01-24 1997-03-12 Smithkline Beecham Biolog Novel device
US6036680A (en) 1997-01-27 2000-03-14 Baxter International Inc. Self-priming solution lines and a method and system for using same
US6053191A (en) 1997-02-13 2000-04-25 Hussey; James J. Mud-saver valve
US5771914A (en) 1997-02-13 1998-06-30 Baxter International Inc. Flexible fluid junction
US6579253B1 (en) 1997-02-14 2003-06-17 Nxstage Medical, Inc. Fluid processing systems and methods using extracorporeal fluid flow panels oriented within a cartridge
US6979309B2 (en) 1997-02-14 2005-12-27 Nxstage Medical Inc. Systems and methods for performing blood processing and/or fluid exchange procedures
US6852090B2 (en) 1997-02-14 2005-02-08 Nxstage Medical, Inc. Fluid processing systems and methods using extracorporeal fluid flow panels oriented within a cartridge
US5983947A (en) 1997-03-03 1999-11-16 Medisystems Technology Corporation Docking ports for medical fluid sets
US6051134A (en) 1997-03-28 2000-04-18 Medisystems Technology Corporation Bubble trap having common inlet/outlet tube
US6267242B1 (en) 1997-04-17 2001-07-31 Johnson & Johnson Medical Kabushiki Kaisha Chemical indicator sheets and packaging bags for sterilization made with the use of the same
WO1998050430A2 (en) 1997-05-02 1998-11-12 Somatogen, Inc. Hemoglobin mutants with increased soluble expression and/or reduced nitric oxide scavenging
US6208497B1 (en) 1997-06-26 2001-03-27 Venture Scientifics, Llc System and method for servo control of nonlinear electromagnetic actuators
US6942469B2 (en) 1997-06-26 2005-09-13 Crystal Investments, Inc. Solenoid cassette pump with servo controlled volume detection
US6228047B1 (en) 1997-07-28 2001-05-08 1274515 Ontario Inc. Method and apparatus for performing peritoneal dialysis
US6010623A (en) 1997-08-01 2000-01-04 Medisystems Technology Corporation Bubble trap with flat side
US5893838A (en) 1997-08-15 1999-04-13 Therox, Inc. System and method for high pressure delivery of gas-supersaturated fluids
WO1999010028A1 (en) * 1997-08-22 1999-03-04 Deka Products Limited Partnership System, method and cassette for mixing and delivering intravenous drugs
US6569115B1 (en) 1997-08-28 2003-05-27 Mdc Investment Holdings, Inc. Pre-filled retractable needle injection device
US6200287B1 (en) 1997-09-05 2001-03-13 Gambro, Inc. Extracorporeal blood processing methods and apparatus
US6280406B1 (en) 1997-09-12 2001-08-28 Gambro, Inc Extracorporeal blood processing system
DE19742632A1 (en) 1997-09-26 1999-04-08 Fresenius Medical Care De Gmbh Pumping and dosing device
US5961700A (en) 1997-10-31 1999-10-05 Sims Level 1 Filter system for removal of gas and particulates from cellular fluids
WO1999025033A1 (en) 1997-11-12 1999-05-20 Deka Products Limited Partnership Piezo-electric actuator operable in an electrolytic fluid
US6013060A (en) * 1997-11-19 2000-01-11 Woodard; Robert W. Intravenous liquid flow regulator
GB9724988D0 (en) 1997-11-27 1998-01-28 Cole David J Valve
DE19802615A1 (en) 1998-01-24 1999-08-12 Manfred Adolfs Connecting element for connecting a transducer to a sealed fluid system
JP3997318B2 (en) 1998-02-16 2007-10-24 株式会社サタコ Pump control method and control apparatus
US6485450B1 (en) * 1998-03-16 2002-11-26 Life Science Holdings, Inc. Brain resuscitation apparatus and method
DE19814101A1 (en) 1998-03-30 1999-10-14 Fresenius Medical Care De Gmbh Process for the airtight connection of two membranes
DE19814695C2 (en) 1998-04-01 2001-09-13 Fresenius Medical Care De Gmbh Cassette for conveying liquids, in particular dialysis liquids, dialysis machine and method for conveying, balancing, dosing and heating a medical fluid
EP1066068B1 (en) 1998-04-02 2006-07-12 Debiotech S.A. Device for peritoneal dialysis
CA2236049C (en) 1998-04-27 2006-07-25 Computer Controlled Syringe Inc. Syringe with detachable syringe barrel
US6071269A (en) 1998-05-13 2000-06-06 Medisystems Technology Corporation Blood set and chamber
JP3364155B2 (en) 1998-06-05 2003-01-08 東京エレクトロン株式会社 Coating film forming apparatus and method
US6019824A (en) 1998-06-09 2000-02-01 Medisystems Technology Corporation Bubble trap chamber
US6343614B1 (en) 1998-07-01 2002-02-05 Deka Products Limited Partnership System for measuring change in fluid flow rate within a line
US6041801A (en) 1998-07-01 2000-03-28 Deka Products Limited Partnership System and method for measuring when fluid has stopped flowing within a line
US6152705A (en) 1998-07-15 2000-11-28 Wilden Pump & Engineering Co. Air drive pumps and components therefor
US6759014B2 (en) 2001-01-26 2004-07-06 Symyx Technologies, Inc. Apparatus and methods for parallel processing of multiple reaction mixtures
DE19837667A1 (en) 1998-08-19 2000-03-02 Fresenius Medical Care De Gmbh Multifunction sensor
US6620189B1 (en) * 2000-02-28 2003-09-16 Radiant Medical, Inc. Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter
US6337049B1 (en) 1998-08-28 2002-01-08 Yehuda Tamari Soft shell venous reservoir
JP2000070358A (en) 1998-09-01 2000-03-07 Nissho Corp Medical pump
US6695593B1 (en) 1998-10-05 2004-02-24 Trebor International, Inc. Fiber optics systems for high purity pump diagnostics
US6957952B1 (en) 1998-10-05 2005-10-25 Trebor International, Inc. Fiber optic system for detecting pump cycles
US6106246A (en) 1998-10-05 2000-08-22 Trebor International, Inc. Free-diaphragm pump
US6695803B1 (en) * 1998-10-16 2004-02-24 Mission Medical, Inc. Blood processing system
US6223130B1 (en) 1998-11-16 2001-04-24 Deka Products Limited Partnership Apparatus and method for detection of a leak in a membrane of a fluid flow control system
US6383158B1 (en) 1998-12-01 2002-05-07 Dsu Medical Corporation Dialysis pressure monitoring with clot suppression
US6312412B1 (en) 1998-12-02 2001-11-06 V. C. Saied, M.D. Apparatus and method for painless intramuscular or subcutaneous injections
DE19856744C2 (en) 1998-12-09 2003-06-26 Plasmaselect Ag Pump hose system for peristaltic delivery of liquid or gaseous media
JP3924386B2 (en) 1998-12-28 2007-06-06 日本エム・ケー・エス株式会社 Flow control system
US6227807B1 (en) 1999-02-02 2001-05-08 Eric Chase Constant flow fluid pump
US6645177B1 (en) 1999-02-09 2003-11-11 Alaris Medical Systems, Inc. Directly engaged syringe driver system
US6132187A (en) 1999-02-18 2000-10-17 Ericson; Paul Leonard Flex-actuated bistable dome pump
DE19919572C2 (en) 1999-04-29 2002-04-18 Fresenius Medical Care De Gmbh Method and device for determining gas in medical liquids
JP2000346214A (en) 1999-06-07 2000-12-15 Watanabegumi:Kk Balloon valve
US6168394B1 (en) 1999-06-18 2001-01-02 Wilden Pump & Engineering Co. Air driven double diaphragm pump
US6164621A (en) 1999-07-09 2000-12-26 Deka Products Limited Partnership Simplified piezoelectric valve
US6416293B1 (en) 1999-07-20 2002-07-09 Deka Products Limited Partnership Pumping cartridge including a bypass valve and method for directing flow in a pumping cartridge
US6382923B1 (en) 1999-07-20 2002-05-07 Deka Products Ltd. Partnership Pump chamber having at least one spacer for inhibiting the pumping of a gas
US6905479B1 (en) 1999-07-20 2005-06-14 Deka Products Limited Partnership Pumping cartridge having an integrated filter and method for filtering a fluid with the cartridge
US6604908B1 (en) 1999-07-20 2003-08-12 Deka Products Limited Partnership Methods and systems for pulsed delivery of fluids from a pump
US6206644B1 (en) 1999-08-06 2001-03-27 Microbar Systems, Inc. Compact dual pump
JP2001067868A (en) 1999-08-31 2001-03-16 Mitsubishi Electric Corp Semiconductor storage
US6296450B1 (en) 1999-09-03 2001-10-02 Baxter International Inc. Systems and methods for control of pumps employing gravimetric sensing
US6294094B1 (en) 1999-09-03 2001-09-25 Baxter International Inc. Systems and methods for sensing red blood cell hematocrit
US6348156B1 (en) 1999-09-03 2002-02-19 Baxter International Inc. Blood processing systems and methods with sensors to detect contamination due to presence of cellular components or dilution due to presence of plasma
US7041076B1 (en) 1999-09-03 2006-05-09 Baxter International Inc. Blood separation systems and methods using a multiple function pump station to perform different on-line processing tasks
US6261065B1 (en) 1999-09-03 2001-07-17 Baxter International Inc. System and methods for control of pumps employing electrical field sensing
US6270673B1 (en) 1999-09-03 2001-08-07 Baxter International Inc. Door latching assembly for holding a fluid pressure actuated cassette during use
US6284142B1 (en) 1999-09-03 2001-09-04 Baxter International Inc. Sensing systems and methods for differentiating between different cellular blood species during extracorporeal blood separation or processing
US6709412B2 (en) 1999-09-03 2004-03-23 Baxter International Inc. Blood processing systems and methods that employ an in-line leukofilter mounted in a restraining fixture
US6949079B1 (en) 1999-09-03 2005-09-27 Baxter International Inc. Programmable, fluid pressure actuated blood processing systems and methods
US6481980B1 (en) 1999-09-03 2002-11-19 Baxter International Inc. Fluid flow cassette with pressure actuated pump and valve stations
US6325775B1 (en) 1999-09-03 2001-12-04 Baxter International Inc. Self-contained, transportable blood processsing device
US6524231B1 (en) 1999-09-03 2003-02-25 Baxter International Inc. Blood separation chamber with constricted interior channel and recessed passage
US6759007B1 (en) 1999-09-03 2004-07-06 Baxter International Inc. Blood processing systems and methods employing fluid pressure actuated pumps and valves
US6315707B1 (en) 1999-09-03 2001-11-13 Baxter International Inc. Systems and methods for seperating blood in a rotating field
US6322488B1 (en) 1999-09-03 2001-11-27 Baxter International Inc. Blood separation chamber with preformed blood flow passages and centralized connection to external tubing
US6723062B1 (en) 1999-09-03 2004-04-20 Baxter International Inc. Fluid pressure actuated blood pumping systems and methods with continuous inflow and pulsatile outflow conditions
US6297322B1 (en) 1999-09-09 2001-10-02 Baxter International Inc. Cycloolefin blends and method for solvent bonding polyolefins
US6250502B1 (en) 1999-09-20 2001-06-26 Daniel A. Cote Precision dispensing pump and method of dispensing
US7255680B1 (en) 1999-10-27 2007-08-14 Cardinal Health 303, Inc. Positive pressure infusion system having downstream resistance measurement capability
US6285155B1 (en) 1999-10-29 2001-09-04 Abbott Laboratories Pseudo half-step motor drive method and apparatus
US6517508B1 (en) 1999-11-03 2003-02-11 Dsu Medical Corporation Set for blood processing
AU784195B2 (en) 1999-11-12 2006-02-16 Baxter Biotech Technology S.A.R.L. Reduced side-effect hemoglobin compositions
US6746637B1 (en) 1999-11-15 2004-06-08 Westinghouse Air Brake Technologies Corporation Process for making chemical resistant pump diaphragm
EP1240494A2 (en) * 1999-11-29 2002-09-18 NxStage Medical, Inc. Systems and methods for detecting air in an arterial blood line of a blood processing circuit
US6790198B1 (en) 1999-12-01 2004-09-14 B-Braun Medical, Inc. Patient medication IV delivery pump with wireless communication to a hospital information management system
US6519569B1 (en) 1999-12-01 2003-02-11 B. Braun Medical, Inc. Security infusion pump with bar code reader
US7645258B2 (en) 1999-12-01 2010-01-12 B. Braun Medical, Inc. Patient medication IV delivery pump with wireless communication to a hospital information management system
US6208107B1 (en) 1999-12-03 2001-03-27 Abbott Laboratories Use of digital current ramping to reduce audible noise in stepper motor
US6774517B2 (en) 2000-02-01 2004-08-10 Tritex Corporation Injection molded threaded rotor and manufacture method
US6497676B1 (en) 2000-02-10 2002-12-24 Baxter International Method and apparatus for monitoring and controlling peritoneal dialysis therapy
CA2401222C (en) * 2000-02-28 2010-04-27 Radiant Medical, Inc. Disposable cassette for intravascular heat exchange catheter
EP1946783B1 (en) 2000-03-09 2011-09-07 CaridianBCT, Inc. Extracorporeal blood processing apparatus
US6485465B2 (en) 2000-03-29 2002-11-26 Medtronic Minimed, Inc. Methods, apparatuses, and uses for infusion pump fluid pressure and force detection
US6752599B2 (en) 2000-06-09 2004-06-22 Alink M, Inc. Apparatus for photoresist delivery
US6503062B1 (en) 2000-07-10 2003-01-07 Deka Products Limited Partnership Method for regulating fluid pump pressure
US20020048581A1 (en) 2000-07-18 2002-04-25 King George L. Modulation of nitric oxide synthase by PKC
DE10042324C1 (en) * 2000-08-29 2002-02-07 Fresenius Medical Care De Gmbh Blood dialysis device has feed line provided with 2 parallel branches for single needle and dual needle operating modes
WO2002023167A1 (en) 2000-09-11 2002-03-21 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Fluidics system
US6398513B1 (en) 2000-09-20 2002-06-04 Fluid Management, Inc. Fluid dispensers
DE10046651A1 (en) * 2000-09-20 2002-04-04 Fresenius Medical Care De Gmbh Valve
EP1195171B1 (en) 2000-10-04 2012-08-15 Terumo Kabushiki Kaisha Peritoneal dialysis apparatus
JP4643815B2 (en) * 2000-10-04 2011-03-02 テルモ株式会社 Peritoneal dialysis machine
DE10049900C1 (en) 2000-10-10 2001-10-25 Fresenius Medical Care De Gmbh Intraperitoneal volume determination method for peritoneal dialysis uses measured concentration of body substance in peritoneal solution circulated through peritoneal space during dialysis
DE60137249D1 (en) 2000-10-12 2009-02-12 Renal Solutions Inc APPARATUS FOR CONTROLLING RIVER OF BODY FLUIDS FOR EXTRACORPOREAL LIQUID TREATMENTS
DE10053441B4 (en) * 2000-10-27 2004-04-15 Fresenius Medical Care Deutschland Gmbh Disposable cassette with sealing membrane and valve actuator therefor
US6489896B1 (en) 2000-11-03 2002-12-03 Baxter International Inc. Air in-line sensor for ambulatory drug infusion pump
US6572604B1 (en) 2000-11-07 2003-06-03 Baxter International Inc. Occlusion detection method and system for ambulatory drug infusion pump
US6603229B1 (en) 2000-11-15 2003-08-05 Tri-Tech, Inc. Linear actuator with threaded captivation sleeve, captive lead screw, and spring pre-load adjustment
US6471855B1 (en) * 2000-11-22 2002-10-29 Baxter International Inc. Cassette with integral separation device
US6367669B1 (en) 2000-12-14 2002-04-09 Asm Assembly Automation Ltd. Fluid dispensing apparatus
EP1347705B1 (en) 2000-12-21 2005-12-07 Insulet Corporation Medical apparatus remote control
SE523860C2 (en) 2001-01-08 2004-05-25 Gambro Lundia Ab Coupling device and medical wiring set with such coupling device
US20020098097A1 (en) 2001-01-22 2002-07-25 Angad Singh Magnetically-actuated micropump
DK1399193T3 (en) 2001-02-16 2014-03-31 Piedmont Renal Clinics P A Automated peritoneal dialysis system and method of in-line sterilization of the dialysate
US6529573B2 (en) 2001-03-09 2003-03-04 The Regents Of The University Of California Proton recoil scintillator neutron rem meter
US6773412B2 (en) 2001-04-13 2004-08-10 Chf Solutions, Inc. User interface for blood treatment device
US6494694B2 (en) 2001-04-25 2002-12-17 Abbott Laboratories Disposable infusion cassette with low air bubble retention and improved valves
US7306578B2 (en) 2002-01-04 2007-12-11 Deka Products Limited Partnership Loading mechanism for infusion pump
ITTO20010583A1 (en) 2001-06-15 2002-12-15 Gambro Dasco Spa BLOOD CIRCULATION CIRCUIT FOR A DIALYSIS MACHINE AND RELATED DIALYSIS MACHINE.
EP1414996B1 (en) 2001-07-10 2010-12-01 Johnson & Johnson Research Pty Limited Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells
US6775577B2 (en) 2001-07-18 2004-08-10 Fresenius Usa, Inc. Method and system for controlling a medical device
US6834647B2 (en) 2001-08-07 2004-12-28 Datex-Ohmeda, Inc. Remote control and tactile feedback system for medical apparatus
DE10143137C1 (en) * 2001-09-03 2003-04-17 Fresenius Medical Care De Gmbh Measuring device and method for determining parameters of medical liquids and method for calibrating such a device
DE10157924C1 (en) 2001-11-26 2003-06-26 Fresenius Medical Care De Gmbh Medical fluid treatment device
US7107837B2 (en) 2002-01-22 2006-09-19 Baxter International Inc. Capacitance fluid volume measurement
US20060173395A1 (en) 2002-02-12 2006-08-03 Brugger James M Set for blood processing
US7544179B2 (en) 2002-04-11 2009-06-09 Deka Products Limited Partnership System and method for delivering a target volume of fluid
US20040136843A1 (en) 2002-04-12 2004-07-15 Bayer Aktiengesellschaft Diaphragm pump
DE10216146A1 (en) 2002-04-12 2003-10-30 Bayer Ag diaphragm pump
US20040109769A1 (en) 2002-04-12 2004-06-10 Bayer Aktiengesellschaft Diaphragm pump
US7021148B2 (en) 2002-04-30 2006-04-04 Baxter International Inc. Apparatus and method for sealing pressure sensor membranes
ITMI20021028A1 (en) 2002-05-14 2003-11-14 Dideco Spa PUMPING UNIT OF FLUID IN PARTICULAR BLOOD
US6929751B2 (en) 2002-05-24 2005-08-16 Baxter International Inc. Vented medical fluid tip protector methods
US7115228B2 (en) 2002-05-24 2006-10-03 Baxter International Inc. One-piece tip protector and organizer
US7153286B2 (en) 2002-05-24 2006-12-26 Baxter International Inc. Automated dialysis system
US7087036B2 (en) 2002-05-24 2006-08-08 Baxter International Inc. Fail safe system for operating medical fluid valves
US6764761B2 (en) 2002-05-24 2004-07-20 Baxter International Inc. Membrane material for automated dialysis system
US20030217957A1 (en) 2002-05-24 2003-11-27 Bowman Joseph H. Heat seal interface for a disposable medical fluid unit
US7033539B2 (en) 2002-05-24 2006-04-25 Baxter International Inc. Graphical user interface for automated dialysis system
US20030220607A1 (en) * 2002-05-24 2003-11-27 Don Busby Peritoneal dialysis apparatus
US7175606B2 (en) 2002-05-24 2007-02-13 Baxter International Inc. Disposable medical fluid unit having rigid frame
US20030217961A1 (en) 2002-05-24 2003-11-27 Peter Hopping Electrically insulated automated dialysis system
DE10224750A1 (en) 2002-06-04 2003-12-24 Fresenius Medical Care De Gmbh Device for the treatment of a medical fluid
US7404809B2 (en) 2004-10-12 2008-07-29 Iradimed Corporation Non-magnetic medical infusion device
US7267661B2 (en) 2002-06-17 2007-09-11 Iradimed Corporation Non-magnetic medical infusion device
US7553295B2 (en) 2002-06-17 2009-06-30 Iradimed Corporation Liquid infusion apparatus
CA2729519C (en) 2002-06-24 2014-11-18 Gambro Lundia Ab Gas separation devices
ATE414549T1 (en) 2002-07-19 2008-12-15 Terumo Corp DEVICE FOR PERITONEAL DIALYSIS
ES2339239T3 (en) 2002-07-19 2010-05-18 Baxter International Inc. SYSTEM FOR PERITONEAL DIALYSIS.
ES2366781T3 (en) 2002-07-19 2011-10-25 Baxter International Inc. SYSTEMS AND METHODS FOR PERITONEAL DIALYSIS.
US7238164B2 (en) 2002-07-19 2007-07-03 Baxter International Inc. Systems, methods and apparatuses for pumping cassette-based therapies
JP4658599B2 (en) 2002-07-24 2011-03-23 デカ・プロダクツ・リミテッド・パートナーシップ Optical deflection sensor for injection devices.
US6746514B2 (en) 2002-08-08 2004-06-08 Baxter International Inc. Gas venting device and a system and method for venting a gas from a liquid delivery system
EP1539271B1 (en) 2002-09-11 2014-04-16 Fresenius Medical Care Deutschland GmbH Blood treatment device for returning blood
EP1403519A1 (en) 2002-09-27 2004-03-31 Novo Nordisk A/S Membrane pump with stretchable pump membrane
US8182440B2 (en) 2002-09-27 2012-05-22 Baxter International Inc. Dialysis machine having combination display and handle
US7297272B2 (en) 2002-10-24 2007-11-20 Fenwal, Inc. Separation apparatus and method
US6846161B2 (en) 2002-10-24 2005-01-25 Baxter International Inc. Blood component processing systems and methods using fluid-actuated pumping elements that are integrity tested prior to use
US6790014B2 (en) 2002-11-06 2004-09-14 John C. Bowen Fluid cooled diaphragms for diaphragm compressors
US7618948B2 (en) 2002-11-26 2009-11-17 Medtronic, Inc. Devices, systems and methods for improving and/or cognitive function through brain delivery of siRNA
US7223338B2 (en) 2003-02-07 2007-05-29 Gambro Lundia Ab Support element for an integrated module for blood treatment, an integrated module for blood treatment, and a manufacturing process for an integrated module for blood treatment
WO2004075954A2 (en) 2003-02-21 2004-09-10 Smith & Nephew, Inc. Spinal fluid introduction
US7559911B2 (en) 2003-09-05 2009-07-14 Gambro Lundia Ab Blood chamber for extracorporeal blood circuits and a process for manufacturing the blood chamber
US7160087B2 (en) 2003-09-19 2007-01-09 Hospira, Inc. Pump tube set handling system
US7258534B2 (en) 2003-09-22 2007-08-21 Hospira, Inc. Fluid delivery device identification and loading system
US7490021B2 (en) 2003-10-07 2009-02-10 Hospira, Inc. Method for adjusting pump screen brightness
EP1680155B2 (en) 2003-10-28 2015-11-04 Baxter International Inc. Dialysis machine with improved integrity test
US20050095152A1 (en) 2003-10-30 2005-05-05 Deka Products Limited Partnership Door locking mechanism
US7896572B2 (en) 2003-10-30 2011-03-01 Hospira, Inc. Medical device system
US8038639B2 (en) 2004-11-04 2011-10-18 Baxter International Inc. Medical fluid system with flexible sheeting disposable unit
KR101099962B1 (en) 2003-11-07 2011-12-28 감브로 룬디아 아베 Fluid distribution module and extracorporeal blood circuit including such a module
US7232435B2 (en) 2004-02-06 2007-06-19 Medtronic, Inc. Delivery of a sympatholytic cardiovascular agent to the central nervous system to counter heart failure and pathologies associated with heart failure
US7422905B2 (en) 2004-02-27 2008-09-09 Medtronic, Inc. Blood coagulation test cartridge, system, and method
US7399637B2 (en) 2004-04-19 2008-07-15 Medtronic, Inc. Blood coagulation test cartridge, system, and method
WO2005116623A2 (en) 2004-05-17 2005-12-08 Medtronic, Inc. Point of care heparin determination system
US7507221B2 (en) 2004-10-13 2009-03-24 Mallinckrodt Inc. Powerhead of a power injection system
AU2005319703B2 (en) 2004-12-21 2011-11-03 Becton, Dickinson And Company Syringe assembly having disabling mechanism
US20060195064A1 (en) 2005-02-28 2006-08-31 Fresenius Medical Care Holdings, Inc. Portable apparatus for peritoneal dialysis therapy
US7935074B2 (en) 2005-02-28 2011-05-03 Fresenius Medical Care Holdings, Inc. Cassette system for peritoneal dialysis machine
DE102005011740B4 (en) 2005-03-11 2008-02-14 Maquet Cardiopulmonary Ag Venous bubble trap
US7261559B2 (en) 2005-04-01 2007-08-28 Ultradent Products, Inc. Syringe delivery system for dispensing a dental composite or other highly viscous material
EP1907032A2 (en) 2005-06-30 2008-04-09 Mallinckrodt, Inc. Dual chamber syringe
US8197231B2 (en) 2005-07-13 2012-06-12 Purity Solutions Llc Diaphragm pump and related methods
US7717682B2 (en) 2005-07-13 2010-05-18 Purity Solutions Llc Double diaphragm pump and related methods
DE102005039772A1 (en) 2005-08-22 2007-03-08 Prominent Dosiertechnik Gmbh solenoid
SE529284C2 (en) 2005-11-14 2007-06-19 Johan Stenberg diaphragm Pump
US20080058697A1 (en) 2006-04-14 2008-03-06 Deka Products Limited Partnership Heat exchange systems, devices and methods
US7811252B2 (en) 2006-05-17 2010-10-12 Alcon Research, Ltd. Dosage control device
JP4191755B2 (en) 2006-08-21 2008-12-03 日本電産コパル株式会社 Focal plane shutter for camera
US8870811B2 (en) 2006-08-31 2014-10-28 Fresenius Medical Care Holdings, Inc. Peritoneal dialysis systems and related methods
WO2008065472A1 (en) 2006-12-01 2008-06-05 Gambro Lundia Ab A blood transfer chamber
US8409441B2 (en) 2007-02-27 2013-04-02 Deka Products Limited Partnership Blood treatment systems and methods
US8357298B2 (en) 2007-02-27 2013-01-22 Deka Products Limited Partnership Hemodialysis systems and methods
US8562834B2 (en) 2007-02-27 2013-10-22 Deka Products Limited Partnership Modular assembly for a portable hemodialysis system
US8317492B2 (en) 2007-02-27 2012-11-27 Deka Products Limited Partnership Pumping cassette
US8042563B2 (en) 2007-02-27 2011-10-25 Deka Products Limited Partnership Cassette system integrated apparatus
US7892332B2 (en) 2007-10-01 2011-02-22 Baxter International Inc. Dialysis systems having air traps with internal structures to enhance air removal
US7871462B2 (en) 2007-10-01 2011-01-18 Baxter International Inc. Dialysis systems having air separation chambers with internal structures to enhance air removal
US7892331B2 (en) 2007-10-01 2011-02-22 Baxter International Inc. Dialysis systems having air separation chambers with internal structures to enhance air removal
EP2246080B1 (en) 2007-10-12 2016-02-10 DEKA Products Limited Partnership An extracorporeal blood flow system
US8038640B2 (en) 2007-11-26 2011-10-18 Purity Solutions Llc Diaphragm pump and related systems and methods
DE102007059239A1 (en) 2007-12-07 2009-06-10 Thomas Magnete Gmbh Diaphragm, and reciprocating diaphragm pump
US8708950B2 (en) 2010-07-07 2014-04-29 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US9078971B2 (en) 2008-01-23 2015-07-14 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
CA3017406C (en) 2008-01-23 2023-08-22 Deka Products Limited Partnership Fluid handling cassette for use with a peritoneal dialysis system
US20090212248A1 (en) 2008-02-27 2009-08-27 Eugeniusz Kozak Solenoid-actuated diaphragm valve
EP2113266A1 (en) 2008-04-30 2009-11-04 Gambro Lundia AB Degassing device
US10100827B2 (en) 2008-07-28 2018-10-16 Eaton Intelligent Power Limited Electronic control for a rotary fluid device
CN104564621B (en) 2009-02-12 2017-09-08 伊利诺伊大学受托管理委员会 Magnetic driving micropump
US8192401B2 (en) 2009-03-20 2012-06-05 Fresenius Medical Care Holdings, Inc. Medical fluid pump systems and related components and methods
EP2236077A1 (en) 2009-03-31 2010-10-06 Sensile Pat AG Medical device for measuring an analyte concentration
US8372041B2 (en) 2009-05-08 2013-02-12 The Alfred E. Mann Foundation For Scientific Research In-line fluid transfer devices and ambulatory infusion devices including the same
WO2010128914A1 (en) 2009-05-08 2010-11-11 Xavitech Ab A membrane pump
CN102497895A (en) 2009-07-15 2012-06-13 弗雷塞尼斯医疗保健控股公司 Medical fluid cassettes and related systems and methods
WO2011011434A2 (en) 2009-07-22 2011-01-27 Vbox, Incorporated Gaseous fluid pump
EP2488226B1 (en) 2009-10-15 2013-11-20 Gambro Lundia AB Membrane pump system
US8574201B2 (en) 2009-12-22 2013-11-05 Medtronic Minimed, Inc. Syringe piston with check valve seal
CH702436A1 (en) 2009-12-23 2011-06-30 Jean-Denis Rochat DOSING PUMP FOR MEDICAL USE.
US20110293450A1 (en) 2010-06-01 2011-12-01 Micropump, Inc. Pump magnet housing with integrated sensor element
CA2820589A1 (en) 2010-12-07 2012-06-14 General Compression, Inc. Compressor and/or expander device with rolling piston seal
US8382711B2 (en) 2010-12-29 2013-02-26 Baxter International Inc. Intravenous pumping air management systems and methods
US9624915B2 (en) 2011-03-09 2017-04-18 Fresenius Medical Care Holdings, Inc. Medical fluid delivery sets and related systems and methods
EP2699280B1 (en) 2011-04-21 2015-12-09 Fresenius Medical Care Holdings, Inc. Medical fluid pumping systems and related devices and methods
DE102012200501A1 (en) 2012-01-13 2013-07-18 Robert Bosch Gmbh Microdosing pump and method for manufacturing a microdosing pump
US9610392B2 (en) 2012-06-08 2017-04-04 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
US9500188B2 (en) 2012-06-11 2016-11-22 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
JP6002650B2 (en) 2013-10-25 2016-10-05 京セラドキュメントソリューションズ株式会社 Display input device and image forming apparatus having the same
JP6154314B2 (en) 2013-12-25 2017-06-28 ファナック株式会社 Control device for injection molding machine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378126A (en) * 1992-12-30 1995-01-03 Abbott Laboratories Diaphragm cassette for solution pumping system

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10471194B2 (en) 2002-06-04 2019-11-12 Fresenius Medical Care Deutschland Gmbh Dialysis systems and related methods
US20110303597A2 (en) * 2007-09-10 2011-12-15 Fresenius Medical Care Deutschland Gmbh Device and method for treating a medical fluid and medical cassette
US8470171B2 (en) * 2007-09-10 2013-06-25 Fresenius Medical Care Deutschland Gmbh Device and method for treating a medical fluid and medical cassette
US9669145B2 (en) 2007-09-10 2017-06-06 Fresenius Medical Care Deutschland Gmbh Device and method for treating a medical fluid and medical cassette
US10646631B2 (en) 2007-09-10 2020-05-12 Fresenius Medical Care Deutschland Gmbh Device and method for treating a medical fluid and medical cassette
US20100200486A1 (en) * 2007-09-10 2010-08-12 Guenther Goetz Device and method for treating a medical fluid and medical cassette
US9943634B2 (en) 2009-03-10 2018-04-17 Fresenius Medical Care Deutschland Gmbh Device for connecting multi-functional disposable cassette to extracorporeal blood treatment apparatus
US10507276B2 (en) 2009-07-15 2019-12-17 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
US10143791B2 (en) 2011-04-21 2018-12-04 Fresenius Medical Care Holdings, Inc. Medical fluid pumping systems and related devices and methods
US10463777B2 (en) 2012-06-08 2019-11-05 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
US11478578B2 (en) 2012-06-08 2022-10-25 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
USD917045S1 (en) 2018-08-16 2021-04-20 Deka Products Limited Partnership Slide clamp
USD937413S1 (en) 2018-08-16 2021-11-30 Deka Products Limited Partnership Slide clamp
USD972722S1 (en) 2018-08-16 2022-12-13 Deka Products Limited Partnership Slide clamp
USD1018840S1 (en) 2018-08-16 2024-03-19 Deka Products Limited Partnership Slide clamp
US11478755B2 (en) 2019-08-15 2022-10-25 Fenwal, Inc. Small volume processing systems and methods
USD1004412S1 (en) 2019-08-16 2023-11-14 Deka Products Limited Partnership Slide clamp assembly

Also Published As

Publication number Publication date
US8721883B2 (en) 2014-05-13
US20050230292A1 (en) 2005-10-20
US20120156097A1 (en) 2012-06-21
US20120061310A1 (en) 2012-03-15
US20120181226A1 (en) 2012-07-19
EP2295090A3 (en) 2011-06-08
EP2308525A2 (en) 2011-04-13
AU2003240694A1 (en) 2003-12-19
US8435408B2 (en) 2013-05-07
US7648627B2 (en) 2010-01-19
US8377293B2 (en) 2013-02-19
US8142653B2 (en) 2012-03-27
JP2010012329A (en) 2010-01-21
EP2308525A3 (en) 2011-06-08
CN101676002B (en) 2013-04-24
JP5173981B2 (en) 2013-04-03
CN101676003B (en) 2013-05-22
DE10224750A1 (en) 2003-12-24
JP2010012330A (en) 2010-01-21
US20180117229A1 (en) 2018-05-03
EP2308525B1 (en) 2015-03-25
WO2003101510A1 (en) 2003-12-11
ES2529095T3 (en) 2015-02-16
US9827359B2 (en) 2017-11-28
JP4537198B2 (en) 2010-09-01
JP5032548B2 (en) 2012-09-26
US20100133153A1 (en) 2010-06-03
EP2295090B1 (en) 2015-01-21
US8926835B2 (en) 2015-01-06
EP1509260A1 (en) 2005-03-02
US9101709B2 (en) 2015-08-11
US20150165105A1 (en) 2015-06-18
EP2295090A2 (en) 2011-03-16
US8366921B2 (en) 2013-02-05
CN1658916A (en) 2005-08-24
US20130118970A1 (en) 2013-05-16
ES2464266T3 (en) 2014-06-02
US20120181231A1 (en) 2012-07-19
US10471194B2 (en) 2019-11-12
EP1509260B1 (en) 2014-04-16
US20130118961A1 (en) 2013-05-16
CN101676002A (en) 2010-03-24
CN100553696C (en) 2009-10-28
JP2005528168A (en) 2005-09-22
CN101676003A (en) 2010-03-24

Similar Documents

Publication Publication Date Title
US10471194B2 (en) Dialysis systems and related methods
US11779691B2 (en) Pumping cassette
US4276004A (en) Infusion pump
EP2254616B1 (en) Disposable fluid handling cassette for peritoneal dialysis
CA3233699A1 (en) Medical treatment systems, methods, and apparatuses using a plurality of fluid lines
EP2978466B1 (en) Blood pump
CN219941404U (en) Liquid cartridge for peritoneal dialysis machine and peritoneal dialysis machine
CN116271301A (en) Liquid cartridge for peritoneal dialysis machine and peritoneal dialysis machine

Legal Events

Date Code Title Description
AS Assignment

Owner name: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH, GERMANY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:WEIS, MANFRED;REEL/FRAME:027965/0288

Effective date: 20120322

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION