US20120053253A1 - Gene signatures for cancer prognosis - Google Patents

Gene signatures for cancer prognosis Download PDF

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Publication number
US20120053253A1
US20120053253A1 US13/178,380 US201113178380A US2012053253A1 US 20120053253 A1 US20120053253 A1 US 20120053253A1 US 201113178380 A US201113178380 A US 201113178380A US 2012053253 A1 US2012053253 A1 US 2012053253A1
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Prior art keywords
genes
cancer
expression
test
ccgs
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Abandoned
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US13/178,380
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Inventor
Steven Stone
Alexander Gutin
Susanne Wagner
Julia Reid
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Myriad Genetics Inc
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Myriad Genetics Inc
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Priority to US13/178,380 priority Critical patent/US20120053253A1/en
Assigned to MYRIAD GENETICS, INC. reassignment MYRIAD GENETICS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GUTIN, ALEXANDER, REID, JULIA, WAGNER, SUSANNE, STONE, STEVEN
Publication of US20120053253A1 publication Critical patent/US20120053253A1/en
Priority to US14/632,888 priority patent/US10954568B2/en
Priority to US15/060,090 priority patent/US20160355884A1/en
Priority to US15/921,416 priority patent/US20180334722A1/en
Priority to US17/678,357 priority patent/US20220259675A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
US13/178,380 2010-07-07 2011-07-07 Gene signatures for cancer prognosis Abandoned US20120053253A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US13/178,380 US20120053253A1 (en) 2010-07-07 2011-07-07 Gene signatures for cancer prognosis
US14/632,888 US10954568B2 (en) 2010-07-07 2015-02-26 Gene signatures for cancer prognosis
US15/060,090 US20160355884A1 (en) 2010-07-07 2016-03-03 Gene signatures for cancer prognosis
US15/921,416 US20180334722A1 (en) 2010-07-07 2018-03-14 Gene signatures for cancer prognosis
US17/678,357 US20220259675A1 (en) 2010-07-07 2022-02-23 Gene signatures for cancer prognosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36220910P 2010-07-07 2010-07-07
US13/178,380 US20120053253A1 (en) 2010-07-07 2011-07-07 Gene signatures for cancer prognosis

Related Child Applications (1)

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US14/632,888 Continuation US10954568B2 (en) 2010-07-07 2015-02-26 Gene signatures for cancer prognosis

Publications (1)

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US20120053253A1 true US20120053253A1 (en) 2012-03-01

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Family Applications (5)

Application Number Title Priority Date Filing Date
US13/178,380 Abandoned US20120053253A1 (en) 2010-07-07 2011-07-07 Gene signatures for cancer prognosis
US14/632,888 Active US10954568B2 (en) 2010-07-07 2015-02-26 Gene signatures for cancer prognosis
US15/060,090 Abandoned US20160355884A1 (en) 2010-07-07 2016-03-03 Gene signatures for cancer prognosis
US15/921,416 Abandoned US20180334722A1 (en) 2010-07-07 2018-03-14 Gene signatures for cancer prognosis
US17/678,357 Pending US20220259675A1 (en) 2010-07-07 2022-02-23 Gene signatures for cancer prognosis

Family Applications After (4)

Application Number Title Priority Date Filing Date
US14/632,888 Active US10954568B2 (en) 2010-07-07 2015-02-26 Gene signatures for cancer prognosis
US15/060,090 Abandoned US20160355884A1 (en) 2010-07-07 2016-03-03 Gene signatures for cancer prognosis
US15/921,416 Abandoned US20180334722A1 (en) 2010-07-07 2018-03-14 Gene signatures for cancer prognosis
US17/678,357 Pending US20220259675A1 (en) 2010-07-07 2022-02-23 Gene signatures for cancer prognosis

Country Status (4)

Country Link
US (5) US20120053253A1 (fr)
EP (2) EP2591126B1 (fr)
CA (1) CA2804391A1 (fr)
WO (1) WO2012006447A2 (fr)

Cited By (10)

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WO2014078700A1 (fr) 2012-11-16 2014-05-22 Myriad Genetics, Inc. Signatures génétiques utilisées en vue du pronostic d'un cancer
WO2015127101A1 (fr) * 2014-02-19 2015-08-27 The Trustees Of Columbia University In The City Of New York Procédé et composition pour le diagnostic du cancer agressif de la prostate
WO2015175692A1 (fr) 2014-05-13 2015-11-19 Myriad Genetics, Inc. Signatures génétiques utilisées en vue du pronostic d'un cancer
WO2017120456A1 (fr) 2016-01-06 2017-07-13 Myriad Genetics, Inc. Gènes et signatures génétiques pour le diagnostic et le traitement du mélanome
US9758829B2 (en) 2012-06-22 2017-09-12 Htg Molecular Diagnostics, Inc. Molecular malignancy in melanocytic lesions
WO2017193062A1 (fr) 2016-05-06 2017-11-09 Myriad Genetics, Inc. Signatures génétiques utilisées en vue du pronostic de cancer rénal
US10196697B2 (en) 2013-12-12 2019-02-05 Almac Diagnostics Limited Prostate cancer classification
WO2019232435A1 (fr) * 2018-06-01 2019-12-05 Grail, Inc. Systèmes et méthodes de réseaux neuronaux convolutifs permettant la classification de données
US11581062B2 (en) 2018-12-10 2023-02-14 Grail, Llc Systems and methods for classifying patients with respect to multiple cancer classes
US11746380B2 (en) 2016-10-05 2023-09-05 University Of East Anglia Classification and prognosis of cancer

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US20120041274A1 (en) 2010-01-07 2012-02-16 Myriad Genetics, Incorporated Cancer biomarkers
WO2012006447A2 (fr) 2010-07-07 2012-01-12 Myriad Genetics, Inc. Signatures génétiques utilisées pour le pronostic du cancer
US9605319B2 (en) 2010-08-30 2017-03-28 Myriad Genetics, Inc. Gene signatures for cancer diagnosis and prognosis
WO2012135008A1 (fr) * 2011-03-26 2012-10-04 Oregon Health And Science University Prédicteurs d'expression génique pour le pronostic du cancer
EP2744919A4 (fr) * 2011-08-19 2015-04-08 Myriad Genetics Inc Signatures de gène pour pronostic de cancer du poumon et sélection de thérapie
US9790556B2 (en) 2012-01-05 2017-10-17 Centre National De La Recherche Scientifique (Cnrs) Signature for the diagnosis of lung cancer aggressiveness and genetic instability
GB201200507D0 (en) * 2012-01-13 2012-02-22 Isis Innovation Biomarker
EP4043580A1 (fr) 2013-03-15 2022-08-17 Myriad myPath, LLC Gènes et signatures génétiques pour le diagnostic et le traitement du mélanome
CN105793437B (zh) * 2013-09-23 2020-12-15 芝加哥大学 关于dna损伤制剂用于癌症治疗的方法和组合物
EP3134548A4 (fr) * 2014-04-23 2018-02-28 Myriad Genetics, Inc. Signatures de pronostic du cancer
AU2015284460B2 (en) 2014-07-02 2021-10-07 Myriad Mypath, Llc Genes and gene signatures for diagnosis and treatment of melanoma
WO2020099277A1 (fr) 2018-11-13 2020-05-22 Bracco Imaging Spa Signatures génétiques pour le pronostic de récidive de cancer de la prostate
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Cited By (18)

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EP3812469A1 (fr) 2021-04-28
US20160355884A1 (en) 2016-12-08
WO2012006447A3 (fr) 2012-05-18
WO2012006447A2 (fr) 2012-01-12
US10954568B2 (en) 2021-03-23
EP2591126B1 (fr) 2020-12-30
US20150167103A1 (en) 2015-06-18
US20180334722A1 (en) 2018-11-22
CA2804391A1 (fr) 2012-01-12
EP2591126A2 (fr) 2013-05-15
US20220259675A1 (en) 2022-08-18

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