US20090074890A1 - Substituted Triazoles as Sodium Channel Blockers - Google Patents
Substituted Triazoles as Sodium Channel Blockers Download PDFInfo
- Publication number
- US20090074890A1 US20090074890A1 US10/578,950 US57895004A US2009074890A1 US 20090074890 A1 US20090074890 A1 US 20090074890A1 US 57895004 A US57895004 A US 57895004A US 2009074890 A1 US2009074890 A1 US 2009074890A1
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- US
- United States
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- effective amount
- compound
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
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- Orthopedic Medicine & Surgery (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/578,950 US20090074890A1 (en) | 2003-11-10 | 2004-11-05 | Substituted Triazoles as Sodium Channel Blockers |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51889003P | 2003-11-10 | 2003-11-10 | |
| PCT/US2004/037280 WO2005047270A2 (en) | 2003-11-10 | 2004-11-05 | Substituted triazoles as sodium channel blockers |
| US10/578,950 US20090074890A1 (en) | 2003-11-10 | 2004-11-05 | Substituted Triazoles as Sodium Channel Blockers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US20090074890A1 true US20090074890A1 (en) | 2009-03-19 |
Family
ID=34590316
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US10/578,950 Abandoned US20090074890A1 (en) | 2003-11-10 | 2004-11-05 | Substituted Triazoles as Sodium Channel Blockers |
| US10/985,592 Active 2025-11-25 US7459475B2 (en) | 2003-11-10 | 2004-11-10 | Substituted triazoles as sodium channel blockers |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US10/985,592 Active 2025-11-25 US7459475B2 (en) | 2003-11-10 | 2004-11-10 | Substituted triazoles as sodium channel blockers |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20090074890A1 (zh) |
| EP (1) | EP1694654B1 (zh) |
| JP (1) | JP2007510741A (zh) |
| KR (1) | KR20060123739A (zh) |
| CN (1) | CN1922156A (zh) |
| AT (1) | ATE500234T1 (zh) |
| AU (1) | AU2004289694B2 (zh) |
| BR (1) | BRPI0416319A (zh) |
| CA (1) | CA2545254A1 (zh) |
| DE (1) | DE602004031667D1 (zh) |
| IL (1) | IL175522A0 (zh) |
| IS (1) | IS8438A (zh) |
| NO (1) | NO20062676L (zh) |
| NZ (1) | NZ547044A (zh) |
| RU (1) | RU2372339C2 (zh) |
| WO (1) | WO2005047270A2 (zh) |
| ZA (1) | ZA200603583B (zh) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR044503A1 (es) * | 2003-03-18 | 2005-09-14 | Merck & Co Inc | Triazoles sustituidos con biarilo como bloqueantes del canal de sodio |
| US20090074890A1 (en) * | 2003-11-10 | 2009-03-19 | Park Min K | Substituted Triazoles as Sodium Channel Blockers |
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| GB0603008D0 (en) * | 2006-02-14 | 2006-03-29 | Portela & Ca Sa | Method |
| KR100808551B1 (ko) | 2006-12-01 | 2008-03-03 | 한국생명공학연구원 | 트리아졸 유도체를 유효성분으로 함유하는 대사성 질환 예방 및 치료용 약학적 조성물 |
| EP2118077B1 (en) | 2007-02-08 | 2014-12-24 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| EP2529623A3 (en) * | 2007-04-03 | 2013-03-13 | E. I. du Pont de Nemours and Company | Substituted benzene fungicides |
| CA2703648A1 (en) * | 2007-10-25 | 2009-04-30 | Revalesio Corporation | Bacteriostatic or bacteriocidal compositions and methods |
| EP2215260A4 (en) * | 2007-10-25 | 2011-04-20 | Revalesio Corp | COMPOSITIONS AND METHOD FOR MODULATING CELL MEMBRANE-IMPROVED INTRA-CELLULAR SIGNAL TRANSMISSION |
| AU2008326381B2 (en) * | 2007-11-21 | 2014-10-23 | Decode Genetics Ehf | Biaryl PDE4 inhibitors for treating inflammation |
| EP2628727A3 (en) | 2007-11-21 | 2013-12-25 | Decode Genetics EHF | Biaryl PDE4 inhibitors for treating pulmonary and cardiovascular disorders |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
| AR080055A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de pirazolo-[5,1-b]-oxazol como antagonistas de los receptores de crf -1 |
| JP5748777B2 (ja) | 2010-02-02 | 2015-07-15 | ノバルティス アーゲー | Ｃｒｆ受容体アンタゴニストとしてのシクロヘキシルアミド誘導体 |
| US8546416B2 (en) | 2011-05-27 | 2013-10-01 | Novartis Ag | 3-spirocyclic piperidine derivatives as ghrelin receptor agonists |
| AU2013255458A1 (en) | 2012-05-03 | 2014-10-09 | Novartis Ag | L-malate salt of 2, 7 - diaza - spiro [4.5 ] dec- 7 - yle derivatives and crystalline forms thereof as ghrelin receptor agonists |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7459475B2 (en) * | 2003-11-10 | 2008-12-02 | Merck & Co. Inc. | Substituted triazoles as sodium channel blockers |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19816880A1 (de) * | 1998-04-17 | 1999-10-21 | Boehringer Ingelheim Pharma | Neue Diphenyl-substituierte 5-Ring-Heterocyclen, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
| AR029489A1 (es) * | 2000-03-10 | 2003-07-02 | Euro Celtique Sa | Piridinas, pirimidinas, pirazinas, triazinas sustituidas por arilo, composiciones farmaceuticas y el uso de las mismas para la manufactura de un medicamento |
| PL214230B1 (pl) * | 2000-03-24 | 2013-07-31 | Euro Celtique Sa | Podstawione arylem pirazole i triazole, kompozycja farmaceutyczna je zawierajaca oraz ich zastosowanie |
| AR037233A1 (es) * | 2001-09-07 | 2004-11-03 | Euro Celtique Sa | Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento |
| AR044503A1 (es) * | 2003-03-18 | 2005-09-14 | Merck & Co Inc | Triazoles sustituidos con biarilo como bloqueantes del canal de sodio |
| US20060183897A1 (en) * | 2003-03-18 | 2006-08-17 | Chakravarty Prasun K | Biaryl substituted triazoles as sodium channel blockers |
-
2004
- 2004-11-05 US US10/578,950 patent/US20090074890A1/en not_active Abandoned
- 2004-11-05 AT AT04800897T patent/ATE500234T1/de not_active IP Right Cessation
- 2004-11-05 WO PCT/US2004/037280 patent/WO2005047270A2/en active Application Filing
- 2004-11-05 DE DE602004031667T patent/DE602004031667D1/de active Active
- 2004-11-05 EP EP04800897A patent/EP1694654B1/en active Active
- 2004-11-05 CN CNA2004800329352A patent/CN1922156A/zh active Pending
- 2004-11-05 NZ NZ547044A patent/NZ547044A/en unknown
- 2004-11-05 RU RU2006120426/04A patent/RU2372339C2/ru not_active IP Right Cessation
- 2004-11-05 AU AU2004289694A patent/AU2004289694B2/en not_active Ceased
- 2004-11-05 CA CA002545254A patent/CA2545254A1/en not_active Abandoned
- 2004-11-05 KR KR1020067009120A patent/KR20060123739A/ko not_active Application Discontinuation
- 2004-11-05 BR BRPI0416319-2A patent/BRPI0416319A/pt not_active Application Discontinuation
- 2004-11-05 JP JP2006539729A patent/JP2007510741A/ja not_active Ceased
- 2004-11-10 US US10/985,592 patent/US7459475B2/en active Active
-
2006
- 2006-05-04 IS IS8438A patent/IS8438A/is unknown
- 2006-05-05 ZA ZA200603583A patent/ZA200603583B/xx unknown
- 2006-05-09 IL IL175522A patent/IL175522A0/en unknown
- 2006-06-09 NO NO20062676A patent/NO20062676L/no not_active Application Discontinuation
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7459475B2 (en) * | 2003-11-10 | 2008-12-02 | Merck & Co. Inc. | Substituted triazoles as sodium channel blockers |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE500234T1 (de) | 2011-03-15 |
| NO20062676L (no) | 2006-08-10 |
| IS8438A (is) | 2006-05-04 |
| EP1694654B1 (en) | 2011-03-02 |
| EP1694654A2 (en) | 2006-08-30 |
| RU2372339C2 (ru) | 2009-11-10 |
| DE602004031667D1 (de) | 2011-04-14 |
| NZ547044A (en) | 2010-05-28 |
| CN1922156A (zh) | 2007-02-28 |
| CA2545254A1 (en) | 2005-05-26 |
| WO2005047270A3 (en) | 2005-09-22 |
| AU2004289694A1 (en) | 2005-05-26 |
| JP2007510741A (ja) | 2007-04-26 |
| US7459475B2 (en) | 2008-12-02 |
| WO2005047270A2 (en) | 2005-05-26 |
| IL175522A0 (en) | 2006-09-05 |
| AU2004289694B2 (en) | 2010-05-13 |
| KR20060123739A (ko) | 2006-12-04 |
| US20060020006A1 (en) | 2006-01-26 |
| BRPI0416319A (pt) | 2007-01-09 |
| RU2006120426A (ru) | 2007-12-27 |
| ZA200603583B (en) | 2007-08-29 |
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| Date | Code | Title | Description |
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| AS | Assignment |
Owner name: MERCK & CO., INC., NEW JERSEY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:PARK, MIN K.;CHAKRAVARTY, PRASUN K.;GONZALEZ, EDWARD;AND OTHERS;REEL/FRAME:023473/0272 Effective date: 20050304 Owner name: MERCK & CO., INC., NEW JERSEY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:FISHER, MICHAEL H.;REEL/FRAME:023473/0322 Effective date: 20050915 |
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Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY Free format text: CHANGE OF NAME;ASSIGNOR:MERCK & CO., INC.;REEL/FRAME:023834/0029 Effective date: 20091102 Owner name: MERCK SHARP & DOHME CORP.,NEW JERSEY Free format text: CHANGE OF NAME;ASSIGNOR:MERCK & CO., INC.;REEL/FRAME:023834/0029 Effective date: 20091102 |
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