US20080200784A1 - Method and device for measuring parameters of cardiac function - Google Patents
Method and device for measuring parameters of cardiac function Download PDFInfo
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- US20080200784A1 US20080200784A1 US11/707,095 US70709507A US2008200784A1 US 20080200784 A1 US20080200784 A1 US 20080200784A1 US 70709507 A US70709507 A US 70709507A US 2008200784 A1 US2008200784 A1 US 2008200784A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
- A61B5/02116—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics of pulse wave amplitude
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
- A61B5/029—Measuring or recording blood output from the heart, e.g. minute volume
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4884—Other medical applications inducing physiological or psychological stress, e.g. applications for stress testing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6832—Means for maintaining contact with the body using adhesives
- A61B5/6833—Adhesive patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/04—Arrangements of multiple sensors of the same type
- A61B2562/043—Arrangements of multiple sensors of the same type in a linear array
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/04—Arrangements of multiple sensors of the same type
- A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
Definitions
- the present invention is related to techniques for monitoring vital functions of the human body, including cardiac functions such as cardiac output and central venous blood oxygenation. It relates, in particular, to an optical method and device for the non-invasive and continuous monitoring of cardiac parameters such as blood flow, blood volume and blood oxygen saturation.
- Jugular venous pulse is produced by the changes in blood flow and pressure in central veins caused by right atrial and ventricular filling and contraction.
- the two main objectives of the bedside examination of jugular vein pulse include the estimation of central venous pressure and the inspection of the waveform. Because of its more direct route to the right atrium, the right internal jugular vein is superior for the purpose. Based upon these measurements, physicians can access hemodynamic events in the right atrium and thus diagnose heart diseases and abnormalities.
- the most common cause of elevated jugular venous pressure is an increase in right ventricular pressure such as occurs in patients with pulmonary stenosis, pulmonary hypertension, or right ventricular failure secondary to right ventricular infarction.
- the venous pressure also is elevated when obstruction to right ventricular inflow occurs, such as with tricuspid stenosis or right atrial myxoma, or when constructive pericardial disease impedes right ventricular inflow. It may also result from vena caval obstruction and, at times, an increase blood volume.
- Patients with obstructive pulmonary disease may have an elevated venous pressure only during expiration.
- the conventional technique for measuring venous pulse and waveform has been described in the literature [3].
- the patient is examined at the optimum degree of trunk elevation for visualization of venous pulsations.
- the venous pressure is measured by a ruler as the vertical distance from the top of the oscillating venous column, to the level of the sternal angle plus vertical distance to the right atrium Due to the fact that the venous pulse is in generally very small, and due to complications with patients, this method is challenging for physicians to use and provides approximate values only.
- Cardiac output is defined as the volume of blood circulated per minute. It is equal to the heart rate multiplied by the stroke volume (the amount ejected by the heart with each contraction). Cardiac output is of central importance in the monitoring of cardiovascular health [4]. Accurate clinical assessment of circulatory status is particularly desirable in critically ill patients in the ICU and patients undergoing cardiac, thoracic, or vascular interventions, and has proven valuable in long term follow-up of outpatient therapies. As a patient's hemodynamic status may change rapidly, continuous monitoring of cardiac output will provide information that allows rapid adjustment of therapy. Measurements of cardiac output and blood pressure can also be used to calculate peripheral resistance.
- Pulmonary artery catheter (PAC) thermodilution method is generally accepted as the clinical standard for monitoring cardiac output, to which all other methods are compared as discussed by Conway and Lund-Johansen [6].
- PAC Pulmonary artery catheter
- Indicator dilution techniques There are several indicator dilution techniques including transpulmonary thermodilution (also known as PiCCO technology, Pulsion Medical Technologies of Kunststoff, Germany), transpulmonary lithium dilution method (LiDCO Group plc of London, UK), PAC based thermo-dilution and other methods (Vigilance, Baxter; Opti-Q, Abbott; and TruCCOMS, AorTech). Application of such techniques assumes three major conditions, namely, complete mixing of blood and indicator, no loss of indicator between place of injection and place of detection, and constant blood flow. The errors associated with indicator dilution techniques are primarily related to the violation of these conditions, as discussed by Lund-Johansen [7-8].
- the direct oxygen Fick approach is currently the standard reference technique for cardiac output measurement as discussed by Keinanen et al [9-10]. It is generally considered the most accurate method currently available.
- the NICO (Novametrix) system is a non-invasive device that applies Fick's principle and relies solely on airway gas measurement as described by Botero et al [11]. This method shows a lack of agreement between thermodilution and CO 2 -rebreathing cardiac output as described in Nielsson et al [12], due to unknown ventilation/perfusion inequality in patients.
- Bio-Impedance and conduction techniques The bio-impedance method was developed as a simple, low-cost method that gives information about the cardiovascular system and/or (de)-hydration status of the body in a non-invasive way.
- a diversity of thoracic impedance measurement systems have also been developed. These systems determine CO on a beat-to-beat time basis. Studies have been reported with mostly poor results, but in some exceptional cases, there was good correlation with a reference method. Many of these studies refer to the poor physical principles of the thoracic impedance method as described in Patterson “Fundamentals of impedance cardiography”, IEEE Engineering in Medicine and Biology 1989; 35 to explain the discrepancies.
- Echo-Doppler ultrasound This technique uses ultrasound and the Doppler Effect to measure cardiac output.
- the blood velocity through the aorta causes a ‘Doppler shift’ in the frequency of the returning ultrasound waves.
- Echo-Doppler probes positioned inside the esophagus with their echo window on the thoracic aorta may be used for measuring aortic flow velocity, as discussed by Schinidlin et al [13].
- Aortic cross sectional area is assumed in devices such as the CardioQ, made by Deltex Medical PLC, Chichester, UK, or measured simultaneously as, for example, in the HemoSonic device made by Arrow International. With these minimally invasive techniques what is measured is aortic blood flow, not cardiac output. A fixed relationship between aortic blood flow and cardiac output is assumed. Echo-Doppler ultrasound requires an above average level of skill on the part of the operator of the ultrasound machine to get accurate reliable results.
- Near infrared spectroscopy has been used to non-invasively measure various physiological properties in animal and human subjects.
- the basic principle underlying near infrared spectroscopy is that a physiological medium such as tissues includes a variety of light-absorbing (chromophores) and light-scattering substances which can interact with transmitted low energy near infrared photons.
- chromophores light-absorbing
- light-scattering substances which can interact with transmitted low energy near infrared photons.
- deoxygenated and oxygenated hemoglobins in human blood are the most dominant chromophores in the spectrum range of 400 nm to 1000 nm. Therefore, diff-use optical spectroscopy has been applied to non-invasively measure oxygen levels in the physiological medium in terms of tissue hemoglobin oxygen saturation.
- Technical background for diffuse optical spectroscopy has been discussed in, e.g., Neuman, M.
- the present invention provides a device and method by which cardiac output can be continuously monitored in a non-invasive manner by the optical measure of venous blood flow and blood content including oxygenation.
- a device for measuring the at least one parameter of a cardiac blood vessel in a patient comprises:
- At least one light source that emits light in the 400 nm to 1000 nm wavelength range
- At least one photodetector adapted to receive light emitted by the light source, wherein said light is reflected from or transmitted through tissue of the patient, the output of said photodetector correlating with a parameter of the blood vessel;
- a probe which permits delivery of light from the light source to an external tissue site on the patient in the proximity of a cardiac blood vessel and permits the photodetector to receive light originating from the light source which has been reflected from or transmitted through said patient site.
- a method of generating a waveform of a cardiac blood vessel in a patient comprises the steps of:
- a method of measuring blood content of a chromophore in a patient comprises the steps of:
- directing light having at least first and second selected wavelengths at an external tissue site on the patient that is in the proximity of a cardiac blood vessel, wherein said selected wavelengths are based on the absorption characteristics of the chromophore;
- the waveform is the time varying component of optical signal associated with cardiac activities, which can be also translated into dynamic information of such as blood flow, blood volume and blood content within the vessel or physical displacement of blood vessel.
- FIG. 1 illustrates a top view of a device for monitoring cardiac output in accordance with an aspect of the invention and placement of the device relative to cardiac vessels;
- FIG. 2 illustrates a side view of a device as in FIG. 1 ;
- FIG. 3 illustrates a system incorporating the device of FIG. 1 ;
- FIG. 4 illustrates a signal or waveform produced using a device as in FIG. 1 ;
- FIG. 5(A and B) is a block diagram of a system incorporating a device as in FIG. 1 ;
- FIG. 6 illustrates probes (A, B and C) for use in the device
- FIG. 7 illustrates a top view of embodiments of the invention (A, B) comprising multiple light sources and photodetectors;
- FIG. 8 is a block diagram of a system incorporating a device as in FIG. 7 ;
- FIG. 9 illustrates a top view of embodiments of the invention (A, B, C) comprising multiple photodetectors per light source;
- FIG. 10 illustrates a dual signal (waveform) generated by an embodiment as in FIG. 9 ;
- FIG. 11 illustrates a top view of a cardiac monitoring device according to an embodiment of the invention comprising multiple sensor patches
- FIG. 12 illustrates a waveform obtained using a device in accordance with the invention.
- a device 10 for measuring a parameter of cardiac function in a patient comprising a light source 20 that emits light in the 400 nm to 1000 nm wavelength range, e.g. visible and infra-red light, a photodetector 30 adapted to receive transmitted and reflected light (as shown in FIG. 2 ) and a patch probe 28 for placement on a patient at an external site in the vicinity of a cardiac blood vessel (as shown in FIG. 1 ) which functions as the interface of the device between light source 20 /photodetector 30 and a selected external patient site.
- a light source 20 that emits light in the 400 nm to 1000 nm wavelength range, e.g. visible and infra-red light
- a photodetector 30 adapted to receive transmitted and reflected light
- a patch probe 28 for placement on a patient at an external site in the vicinity of a cardiac blood vessel (as shown in FIG. 1 ) which functions as the interface of the device between light source 20 /photo
- the probe 28 permits delivery of light emitted by the light source 20 to the selected patient site and transfer of light reflected from or transmitted through the patient site to the photodetector 30 .
- the device 10 may additionally comprise a signal-producing means 40 ( FIG. 3 ) which communicates with the photodetector 30 to translate light received by the photodetector 30 into a recordable visual signal or waveform of the cardiac vessel, or central venous pulse, and time course plot of the cardiac parameter ( FIG. 4 ).
- the light source 20 may be any suitable light source such as a laser diode (e.g. RLT7605G, 760 nm, 5 mW, sm, 9.0 mmh, or RLT8510MG, 850 nm, 100 mW, sm, 5.6 mm), a light emitting diode (LED) or a broadband light source emitting a selected wavelength in the range of 400 nm to 1000 nm.
- the light source 20 emits light having a wavelength in the range of 780 nm and 850 nm.
- the light source 20 is powered by an appropriate power supply 18 such as a 12V DC power supply.
- Light from the light source 20 is directed to at least one external tissue site on the patient that is within close proximity to a cardiac blood vessel, such as the internal jugular vein, the external jugular vein and the carotid artery, while the internal jugular vein is preferred.
- a cardiac blood vessel such as the internal jugular vein, the external jugular vein and the carotid artery, while the internal jugular vein is preferred.
- the neck for example, represents a suitable site for monitoring a cardiac parameter.
- light from the light source 20 may be directed or focussed by an optical lens 22 into a transmitting means 24 , such as transmitting optical fiber bundles, for transmission to the selected patient site.
- Receiving means 26 such as optical fiber bundles 26 , may also be used to receive light that is reflected/transmitted from the patient site and convey this light to photodetector 30 ( FIG. 5A ).
- each fibre optic bundle will incorporate fibres manufactured of material appropriate for the transmission of the wave-length of the light emitted from the light source 20 . For example, if the light source 20 emits in the visible wavelength range, both multiple mode plastic and glass optical fibres may be used.
- the transmitting and receiving optical fiber bundles 24 , 26 are set in the patch probe 28 , at distinct spaced sites or may be combined together at a single site.
- Optical mirrors 29 may be utilized to direct or reflect light from the transmitting fiber bundle 24 into the tissue at the selected patient site, and to direct reflected or transmitted light from the patient site into the receiving fiber bundle 26 ( FIG. 6A ).
- the light source 20 and photodetector 30 may be set directly in the patch probe 28 obviating the need for optical fibers as shown in FIG. 6B .
- a combination of the foregoing embodiments may be utilized in which the light source 20 is set directly in the probe 28 to deliver light to the patient site, while the reflected/transmitted light is received by optical fibers 26 for delivery to the photodetector 30 .
- the probe 28 comprises transmitting optical fibers 24 to deliver light from the light source, and a photodetector 30 set directly in the probe 28 ( FIG. 6C ).
- the light source 20 or transmitting optical fibers 24 may be set in the same patch probe 28 as the photodetector 30 or receiving optical fibers 26 , or in a separate patch probe 28 for placement at a distinct site on the patient that is within a suitable distance from the photodetector 30 or receiving optical fibers 26 to permit detection of reflected/transmitted light.
- the distance between the component delivering light to the patient site (light source or transmitting optical fibers) and the component receiving light from the patient site (photodetector or receiving optical fibers) may vary depending on the nature of each of the components, while a typical distance is generally between 2 and 4 cm, for example, 3 cm.
- the patch probe 28 may be made out of any material suitable to support the electronic/optical components it houses, e.g. light source, photodetector, optical fibers or mirrors, and which is compatible for placement on the skin.
- An example of one such suitable material is medical rubber.
- the patch 28 may be held in position manually, may be held in position by adhesives (one side of the patch may be coated with a material that is adhesive to skin such as a hydro gel adhesive) or may be adapted to be held in place with straps at either end thereof that can be tied.
- Opposing ends of the band may also include an adhesive material such as Velcro to facilitate their attachment and hold the device in place.
- the photodetector 30 translates received reflected/transmitted light into a recordable output such as current or voltage.
- An example of a suitable photodetector 30 for use in the present device is a silicon photo diode (e.g. Hamamatsu S8553). Condensor lenses may be incorporated, if required, to refocus the reflected or transmitted beam of light.
- the device 10 may be connected to a signal producing means 40 to provide a visual output.
- the signal producing means 40 may comprise a microprocessor (e.g. digital signal processor, Texas Instruments) or digital acquisition board 42 to digitize the signal from the photodetector 30 , and a display unit 44 , such as a monitor, which is connected to the microprocessor 42 ( FIG.
- the monitor may be portable, and battery operated.
- the absorbance values collected at regular user-determined intervals, for example, 10 data points/mm, are stored as a spreadsheet associated with a cardiac parameter or cardiac output.
- the display unit 44 functions in real-time to display the selected blood vessel waveform against time which can be used as described below to calculate the cardiac parameter or cardiac output.
- FIG. 4 A sample display of the signal or waveform obtained using the present device is shown in FIG. 4 .
- the signal detected by the photodetector 30 that results from a selected blood vessel pulse, changes in the blood volume and content (such as oxygen saturation) inside the blood vessel.
- the blood volume and content in the selected blood vessel affects the absorption of light, thereby resulting in a signal with varying amplitude.
- the amplitude of the detected optical signal will decrease and increase.
- the time course plot of the amplitude of the recorded light reflects the waveform of the jugular vein pulse.
- a device 100 useful to measure blood content, such as the blood oxygen saturation of central venous blood, is provided.
- blood content such as the blood oxygen saturation of central venous blood
- the jugular vein especially the right internal jugular vein, is directly connected to the superior vena cava as shown in FIG. 1
- the jugular vein waveform is representative of the parameters of central venous blood.
- the device 100 comprises at least two light sources 120 , each emitting light of a different wavelength within the range of 400 nm to 1000 nm.
- the device also comprises a photodetector 130 for each light source 120 to receive the transmitted or reflected light at each wavelength.
- each light transmitting component e.g. light source 120 or transmitting optical fibers
- light receiving component e.g. photodetector 130 or receiving optical fibers
- each light transmitting component e.g. light source 120 or transmitting optical fibers
- light receiving component e.g. photodetector 130 or receiving optical fibers
- FIG. 7A or 7 B may be arranged as shown in FIG. 7A or 7 B; however, as one of skill in the art will appreciate, alternative arrangements of the light transmitting components and light receiving components exist which will not affect the function of the device 100 .
- the device 100 may comprise multiple patches 128 , each of which includes a light transmitting component and a light receiving component.
- the device 100 may comprise a single patch 128 including multiple light transmitting components and light receiving components.
- the device 100 may comprise a first patch 128 with one or more light tranmitting components and light receiving components, and a second patch with one or more light transmitting components and corresponding light receiving components.
- the device will also include the circuitry necessary to power the device, and other electronic and/or optical components necessary for its function as previously described.
- the time course variation in the detected signal associated with a cardiac vessel pulse at different wavelengths may be used to calculate the blood content, such as blood oxygen saturation, and other parameters associated with the cardiac vessel pulse.
- blood oxygen saturation As a function of variations in the detected signal caused by cardiac vessel pulse at multiple light wavelengths, e.g. at 780 nm and 850 nm.
- the selected wavelengths for use in blood content determination will vary with the blood entity being determined. This function can be determined through experiment or derived through photon diffusion equations, photon transportation equations or Modified Beer Lambert's Law.
- the detected signal can be expressed as:
- I ⁇ 1 I 0 , ⁇ 1 ⁇ ⁇ - B ⁇ [ ⁇ Hb , ⁇ 1 ⁇ ( C Hb + ⁇ ⁇ ⁇ C Hb ) + ⁇ HbO , ⁇ 1 ⁇ ( C HbO + ⁇ ⁇ ⁇ C HbO ) ] ⁇ L + A ( 1 )
- the relative change in signal from the signal emitted from the light source to the signal detected by the photodetector which is caused by the jugular vein pulse is represented for a first wavelength by:
- ⁇ ⁇ ⁇ I ⁇ 1 ⁇ - B ⁇ [ ⁇ Hb , ⁇ 1 ⁇ ( ⁇ ⁇ ⁇ C Hb ) + ⁇ HbO , ⁇ 1 ⁇ ( ⁇ ⁇ ⁇ C HbO ) ] ⁇ L ; ( 2 )
- Blood oxygenation derived from jugular vein pulse is then determined using the following equation:
- the patch 28 of device 10 comprising light source (s) 20 and photodetector (s) 30 is generally placed on the neck of the patient at a site near a selected blood vessel, for example, the internal jugular vein. It is desirable for the patient to be lying down at about a 30 degree incline. The patient maintains regular breathing during the process of measuring the pulse of the blood vessel.
- Light from the light source 20 is either reflected off of, or transmitted through, the target site on the patient's neck, and detected by the photodetector 30 .
- the photodetector 30 translates the detected light into an output signal that may be digitized for expression as amplitude against time to result in a waveform of the selected blood vessel pulse.
- the amplitude of signals obtained using different wavelengths is used according to Lambert's law as above to determine blood oxygenation.
- a device 200 comprising 1 or more light sources 220 , each emitting selected wavelengths of light in the 400 nm to 1000 nm range.
- Each light source 220 is coupled with at least two photodetectors 230 each adapted to receive light emitted at a given frequency.
- the circuitry required for the function of the device 200 is included in the device such as power supply 18 , as well as the necessary electronic/optical components.
- the device 200 is useful to simultaneously measure multiple cardiac blood vessel pulses, such as jugular venous pulse as well as carotid arterial pulse, thereby generating a dual waveform as illustrated in FIG. 10 , and thus, has utility to simultaneously measure arterial blood oxygenation, S a O 2 , in addition to central venous oxygenation, S jv O 2 , as described above.
- each light source is turned on in sequence, and the amplitude of light emitted from the light source(s) is modulated at a selected frequency, such as 10 kHz.
- Light emitted by a single light source 220 can be sequentially modulated at two alternating frequencies.
- the output from the photodetectors is filtered at a frequency selected to correlate with a given frequency emitted from a light source.
- cardiac output may be measured or monitored.
- the trend of cardiac output can be calculated through Fick's Law as follows:
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Priority Applications (8)
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US11/707,095 US20080200784A1 (en) | 2007-02-16 | 2007-02-16 | Method and device for measuring parameters of cardiac function |
EP08714585.0A EP2120689B1 (en) | 2007-02-16 | 2008-02-13 | Method and device for measuring parameters of cardiac function |
US12/449,146 US8417306B2 (en) | 2007-02-16 | 2008-02-13 | Method and device for measuring parameters of cardiac function |
PCT/CA2008/000262 WO2008098353A1 (en) | 2007-02-16 | 2008-02-13 | Method and device for measuring parameters of cardiac function |
JP2009549346A JP5528816B2 (ja) | 2007-02-16 | 2008-02-13 | 心臓機能のパラメータを測定する方法及び装置 |
AU2008215133A AU2008215133B2 (en) | 2007-02-16 | 2008-02-13 | Method and device for measuring parameters of cardiac function |
CA2676271A CA2676271C (en) | 2007-02-16 | 2008-02-13 | Method and device for measuring parameters of cardiac function |
US13/765,843 US8918153B2 (en) | 2007-02-16 | 2013-02-13 | Method and device for measuring parameters of cardiac function |
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US11/707,095 US20080200784A1 (en) | 2007-02-16 | 2007-02-16 | Method and device for measuring parameters of cardiac function |
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PCT/CA2008/000262 Continuation-In-Part WO2008098353A1 (en) | 2007-02-16 | 2008-02-13 | Method and device for measuring parameters of cardiac function |
US12/449,146 Continuation-In-Part US8417306B2 (en) | 2007-02-16 | 2008-02-13 | Method and device for measuring parameters of cardiac function |
US44914609A Continuation-In-Part | 2007-02-16 | 2009-07-24 |
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US11/707,095 Abandoned US20080200784A1 (en) | 2007-02-16 | 2007-02-16 | Method and device for measuring parameters of cardiac function |
US12/449,146 Active US8417306B2 (en) | 2007-02-16 | 2008-02-13 | Method and device for measuring parameters of cardiac function |
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AU (1) | AU2008215133B2 (ja) |
CA (1) | CA2676271C (ja) |
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JP2010517711A (ja) * | 2007-02-16 | 2010-05-27 | メスピア・ライフサイエンシズ・インコーポレイテッド | 心臓機能のパラメータを測定する方法及び装置 |
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US10827976B2 (en) | 2014-02-24 | 2020-11-10 | The Trustees Of The University Of Pennsylvania | Pressure modulation, motion detection, individualized geometry, and improved optic-skin coupling to improve long term clinical monitoring with diffuse optics |
CN107145697A (zh) * | 2016-02-29 | 2017-09-08 | 深圳市理邦精密仪器股份有限公司 | 血氧饱和度的处理方法和装置 |
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Also Published As
Publication number | Publication date |
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US20090326352A1 (en) | 2009-12-31 |
JP5528816B2 (ja) | 2014-06-25 |
US8417306B2 (en) | 2013-04-09 |
EP2120689B1 (en) | 2016-08-31 |
WO2008098353A1 (en) | 2008-08-21 |
AU2008215133A1 (en) | 2008-08-21 |
CA2676271C (en) | 2017-01-24 |
EP2120689A4 (en) | 2011-06-29 |
AU2008215133B2 (en) | 2013-03-14 |
EP2120689A1 (en) | 2009-11-25 |
JP2010517711A (ja) | 2010-05-27 |
CA2676271A1 (en) | 2008-08-21 |
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