Classifications

• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
  • B65B25/00—Packaging other articles presenting special problems
  • B65B25/008—Packaging other articles presenting special problems packaging of contact lenses
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
  • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
  • A61L12/02—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using physical phenomena, e.g. electricity, ultrasonics or ultrafiltration
  • A61L12/04—Heat
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
  • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
  • B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
  • B65B55/02—Sterilising, e.g. of complete packages

Definitions

• the present invention generally relates to packaging solutions for ophthalmic devices such as contact lenses.
• Blister-packs and glass vials are typically used to individually package each soft contact lens for sale to a customer.
• Saline or deionized water is commonly used to store the lens in the blister-packs, as mentioned in various patents related to the packaging or manufacturing of contact lenses.
• packaging solutions for blister-packs have sometimes been formulated to reduce or eliminate lens folding and sticking.
• polyvinyl alcohol (PVA) has been used in contact lens packaging solutions.
• U.S. Pat. No. 6,440,366 discloses contact lens packaging solutions comprising polyethylene oxide (PEO)/polypropylene oxide (PPO) block copolymers, especially poloxamers or poloxamines.
• contact lenses be as comfortable as possible for wearers. Manufacturers of contact lenses are continually working to improve the comfort of the lenses. Nevertheless, many people who wear contact lenses still experience dryness or eye irritation throughout the day and particularly towards the end of the day. An insufficiently wetted lens at any point in time will cause significant discomfort to the lens wearer. Although wetting drops can be used as needed to alleviate such discomfort, it would certainly be desirable if such discomfort did not arise in the first place.
• a method of preparing a package comprising a storable, sterile ophthalmic device comprising:
• a method for packaging and storing a contact lens comprising, prior to delivery of the contact lens to the customer-wearer, immersing the contact lens in an aqueous contact lens packing solution inside a package and heat sterilizing the solution, wherein the contact lens packing solution comprising a nonionic, nonpolymeric polyol and a nonionic polymeric conditioning agent, wherein the solution has an osmolality of at least about 200 mOsm/kg and a pH of about 6 to about 8.
• a packaging system for the storage of an ophthalmic device comprising a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising a nonionic, nonpolymeric polyol and a nonionic polymeric conditioning agent, wherein the solution has an osmolality of at least about 200 mOsn/kg, a pH of about 6 to about 8 and is heat sterilized.
• a packaging system for the storage of an ophthalmic device comprising:
• the combination lowers the surface friction of a contact lens over that of a lens stored in a buffered saline solution or a lens stored in a buffered saline solution containing a conditioning polymer, thus increasing the lubricity of the lens surface.
• the lens will be more comfortable to wear in actual use and would allow for the extended wear of the lens without irritation or other adverse effects to the cornea.
• the present invention provides a packaging system for the storage of ophthalmic devices intended for direct contact with body tissue or body fluid.
• ophthalmic device refers to devices that reside in or on the eye. These lenses can provide optical correction, wound care, drug delivery, diagnostic functionality or cosmetic enhancement or effect or a combination of these properties.
• Representative examples of such devices include, but are not limited to, soft contact lenses, e.g., a soft, hydrogel lens; soft, non-hydrogel lens and the like, hard contact lenses, e.g., a hard, gas permeable lens material and the like, intraocular lenses, overlay lenses, ocular inserts, optical inserts and the like.
• a lens is considered to be “soft” if it can be folded back upon itself without breaking. Any material known to produce an ophthalmic device including a contact lens can be used herein.
• the preferred substrates are hydrogel materials, including silicone hydrogel materials.
• Particularly preferred materials include vinyl functionalized polydimethylsiloxanes copolymerized with hydrophilic monomers as well as fluorinated methacrylates and methacrylate functionalized fluorinated polyethylene oxides copolymerized with hydrophilic monomers.
• Representative examples of substrate materials for use herein include those disclosed in U.S. Pat. Nos.
• Hydrogels in general are a well-known class of materials that comprise hydrated, cross-linked polymeric systems containing water in an equilibrium state. Silicone hydrogels generally have a water content greater than about 5 weight percent and more commonly between about 10 to about 80 weight percent. Such materials are usually prepared by polymerizing a mixture containing at least one silicone-containing monomer and at least one hydrophilic monomer. Typically, either the silicone-containing monomer or the hydrophilic monomer functions as a crosslinking agent (a crosslinker being defined as a monomer having multiple polymerizable functionalities) or a separate crosslinker may be employed.
• a crosslinking agent a crosslinker being defined as a monomer having multiple polymerizable functionalities
• silicone-containing monomeric units include bulky polysiloxanylalkyl(meth)acrylic monomers.
• An example of a bulky polysiloxanylalkyl(meth)acrylic monomer is represented by the structure of Formula I:
• X denotes —O— or —NR—; each R 1 independently denotes hydrogen or methyl; each R 2 independently denotes a lower alkyl radical, phenyl radical or a group represented by
• each R 2 independently denotes a lower alkyl or phenyl radical; and h is 1 to 10.
• Examples of bulky monomers are methacryloxypropyl tris(trimethylsiloxy)silane or tris(trimethylsiloxy)silylpropyl methacrylate, sometimes referred to as TRIS and tris(trimethylsiloxy)silylpropyl vinyl carbamate, sometimes referred to as TRIS-VC and the like.
• Such bulky monomers may be copolymerized with a silicone macromonomer, which is a poly(organosiloxane) capped with an unsaturated group at two or more ends of the molecule.
• a silicone macromonomer which is a poly(organosiloxane) capped with an unsaturated group at two or more ends of the molecule.
• U.S. Pat. No. 4,153,641 discloses, for example, various unsaturated groups such as acryloxy or methacryloxy groups.
• silicone-containing monomers includes, but is not limited to, silicone-containing vinyl carbonate or vinyl carbamate monomers such as, for example, 1,3-bis[4-vinyloxycarbonyloxy)but-1-yl]tetramethyl-disiloxane; 3-(trimethylsilyl)propyl vinyl carbonate; 3-(vinyloxycarbonylthio)propyl-[tris(trimethylsiloxy)silane]; 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbamate; 3-[tris(trimethylsiloxy)silyl]propyl allyl carbamate; 3-[tris(trimethylsiloxy)silyl]propyl vinyl carbonate; t-butyldimethylsiloxyethyl vinyl carbonate; trimethylsilylethyl vinyl carbonate; trimethylsilylmethyl vinyl carbonate and the like and mixtures thereof.
• silicone-containing vinyl carbonate or vinyl carbamate monomers such as, for example, 1,3
• silicone-containing monomers includes polyurethane-polysiloxane macromonomers (also sometimes referred to as prepolymers), which may have hard-soft-hard blocks like traditional urethane elastomers. They may be end-capped with a hydrophilic monomer such as 2-hydroxyethyl methacrylate (HEMA).
• HEMA 2-hydroxyethyl methacrylate
• Examples of such silicone urethanes are disclosed in a variety or publications, including U.S. Pat. No. 6,858,218 and PCT Published Application No. WO 96/31792, which disclosures are hereby incorporated by reference in their entirety. Further examples of silicone urethane monomers are represented by Formulae II and III:
• D independently denotes an alkyl diradical, an alkyl cycloalkyl diradical, a cycloalkyl diradical, an aryl diradical or an alkylaryl diradical having 6 to about 30 carbon atoms;
• G independently denotes an alkyl diradical, a cycloalkyl diradical, an alkyl cycloalkyl diradical, an aryl diradical or an alkylaryl diradical having 1 to about 40 carbon atoms and which may contain ether, thio or amine linkages in the main chain;
• a is at least 1;
• A independently denotes a divalent polymeric radical of Formula IV:
• each R s independently denotes an alkyl or fluoro-substituted alkyl group having 1 to about 10 carbon atoms which may contain ether linkages between the carbon atoms; m′ is at least 1; and p is a number that provides a moiety weight of about 400 to about 10,000;
• each of E and E′ independently denotes a polymerizable unsaturated organic radical represented by Formula V:
• R 3 is hydrogen or methyl
• m is at least 1 and is preferably 3 or 4
• a is at least 1 and preferably is 1
• p is a number which provides a moiety weight of about 400 to about 10,000 and is preferably at least about 30
• R 7 is a diradical of a diisocyanate after removal of the isocyanate group, such as the diradical of isophorone diisocyanate
• each E′′ is a group represented by:
• a silicone hydrogel material comprises (in bulk, that is, in the monomer mixture that is copolymerized) about 5 to about 50 percent, and preferably about 10 to about 25, by weight of one or more silicone macromonomers, about 5 to about 75 percent, and preferably about 30 to about 60 percent, by weight of one or more polysiloxanylalkyl (meth)acrylic monomers, and about 10 to about 50 percent, and preferably about 20 to about 40 percent, by weight of a hydrophilic monomer.
• the silicone macromonomer is a poly(organosiloxane) capped with an unsaturated group at two or more ends of the molecule.
• the silane macromonomer is a silicone-containing vinyl carbonate or vinyl carbamate or a polyurethane-polysiloxane having one or more hard-soft-hard blocks and end-capped with a hydrophilic monomer.
• Suitable hydrophilic monomers include amides such as dimethylacrylamide and dimethylmethacrylamide, cyclic lactams such as n-vinyl-2-pyrrolidone and poly(alkene glycols) functionalized with polymerizable groups.
• useful functionalized poly(alkene glycols) include poly(diethylene glycols) of varying chain length containing monomethacrylate or dimethacrylate end caps.
• the poly(alkene glycol) polymer contains at least two alkene glycol monomeric units.
• Still further examples are the hydrophilic vinyl carbonate or vinyl carbamate monomers disclosed in U.S. Pat. No. 5,070,215, and the hydrophilic oxazolone monomers disclosed in U.S. Pat. No. 4,910,277.
• Other suitable hydrophilic monomers will be apparent to one skilled in the art.
• an ophthalmic lens for use herein can be a cationic lens such as a cationic contact lens or fluorinated silicone-containing monomers.
• a cationic lens such as a cationic contact lens or fluorinated silicone-containing monomers.
• Such monomers have been used in the formation of fluorosilicone hydrogels to reduce the accumulation of deposits on contact lenses made therefrom, as disclosed in, for example, U.S. Pat. Nos. 4,954,587; 5,010,141 and 5,079,319.
• silicone-containing monomers having certain fluorinated side groups i.e., —(CF 2 )—H
• silicone-containing monomers having certain fluorinated side groups i.e., —(CF 2 )—H
• Ophthalmic devices such as contact lenses for application of the present invention can be manufactured employing various conventional techniques, to yield a shaped article having the desired posterior and anterior lens surfaces.
• Spincasting methods are disclosed in U.S. Pat. Nos. 3,408,429 and 3,660,545; static casting methods are disclosed in U.S. Pat. Nos. 4,113,224, 4,197,266, and 5,271,875.
• Extended lenses are lenses capable of being worn overnight, preferably capable of being worn for at least one week, most preferably capable of wear for a continuous period of one week to one month.
• “capable” is meant lenses approved by one or more governmental regulatory authorities for such consumer use, for example, the U.S. Food & Drug Administration (USFDA) in the U.S. or its equivalent in other countries.
• USFDA U.S. Food & Drug Administration
• Extended-wear lenses require relatively high oxygen permeability.
• the oxygen-permeability is the rate at which oxygen will pass through a material.
• the oxygen-permeability (Dk) of a lens material does not depend on lens thickness. Oxygen permeability is measured in terms of barrers.
• the oxygen transmissibility of a lens is the rate at which oxygen will pass through a specific lens.
• Oxygen transmissibility, Dk/t is conventionally expressed in units of barrers/mm, where t is the average thickness of the material (in units of mm) over the area being measured.
• a lens having a Dk of about 90 barrers (oxygen-permeability barrers) and a thickness of about 90 microns (about 0.090 mm) would have a Dk/t of about 100 barrers/mm (oxygen transmissibility barrers/mm).
• a packaging system for the storage of an ophthalmic lens according to the present invention includes at least a sealed container containing one or more unused ophthalmic lenses immersed in an aqueous lens packaging solution.
• the sealed container is a hermetically sealed blister-pack, in which a concave well containing a contact lens is covered by a metal or plastic sheet adapted for peeling in order to open the blister-pack.
• the sealed container may be any suitable generally inert packaging material providing a reasonable degree of protection to the lens, preferably a plastic material such as polyalkylene, PVC, polyamide, and the like.
• any suitable nonionic polymeric conditioning agent component may be employed in accordance with the present invention provided that it functions as described herein and has no substantial detrimental effect on the contact lens being stored or on the wearer of the contact lens.
• This component is ophthalmically acceptable at the concentrations used.
• Particularly useful components are those, which are water soluble, for example, soluble at the concentrations used in the presently useful liquid aqueous media.
• These compounds condition the lens by providing one or more of the following attributes: increased viscosity for increase retention time on the lens; enhanced wetting of the lens surface; decreased surface friction; or enhanced comfort of a contact lens by forming a cushioning film over the lens surface.
• a class of nonionic, polymeric conditioning agents includes nonionic polysaccharides.
• suitable components for use herein include, but are not limited to, methylcellulose; hydroxyethylcellulose; hydroxypropylcellulose; hydroxypropylmethylcellulose; and methylhydroxyethyl starches.
• nonionic, polymeric conditioning agents includes polyvinylalcohols and polyvinylpyrrolidones.
• nonionic, polymeric conditioning agents includes polymers of PEO, including PEO homopolymers, and block copolymers of PEO and PPO.
• This class includes poloxamers and poloxamines, including those disclosed in U.S. Pat. No. 6,440,366.
• nonionic, polymeric conditioning agents are intended for illustrative purposes only and not to limit the scope of the present invention.
• Such polymers are known to those of skill in the art.
• the average molecular weight of nonionic, polymeric conditioning agent is a minimum of about 1 kDa and a maximum of about 700 kDa, more preferably, about 5 kDa to 500 kDa.
• the amount of nonionic, polymeric conditioning agent employed is that amount effective to improve the surface properties of the ophthalmic device when combined with a nonionic, nonpolymeric polyol.
• the nonionic, polymeric conditioning agent is present in the packaging solution of the invention in an amount of at least 0.01% w/v.
• the specific amount of such component used can vary widely depending on a number of factors, for example, the specific polymeric component and nonionic polyol being employed.
• the concentration of the nonionic, polymeric conditioning agent is from about 0.01 to about 10% w/w and preferably from about 0.5 to about 1.5% w/w.
• the nonionic, nonpolymeric polyol for use herein can be a nonionic polyol containing 2 to about 12 carbon atoms and preferably 2 to 4 carbon atoms and from 2 to 8 hydroxyl groups.
• Representative examples of such nonionic polyols include glycerin, ethylene glycol, propylene glycol, sorbitol, manitol, monosaccarides, disaccharides such as trehalose, and the like and mixtures thereof.
• the nonionic polyol can be glycerin, ethylene glycol, sorbitol, mannitol, monosaccharides and mixtures thereof.
• the amount of the nonionic, nonpolymeric polyol in the packaging solution will generally be an amount sufficient to form a more uniform coating on the surface of the lens when packaged in a packaging solution according to the present invention.
• the concentration of the nonionic polyol will ordinarily range from about 0.01 to about 10% w/w and preferably from about 0.1 to about 3.0% w/w.
• nonionic, nonpolymeric polyol molecules are able to penetrate into the matrix of the lens material, especially a hydrogel lens material, thus attracting and binding water molecules into the lens matrix.
• the polymeric conditioning agent forms a film around the lens, thus trapping and retaining the moisture and leading to a slow release of the polyol throughout the duration of wear.
• preferred polyols are humectants, which are substances that attract and retain moisture because of their ability to form hydrogen bonds with water molecules, and preferred polymeric conditioning agents are demulcents.
• the packaging solutions according to the present invention are physiologically compatible.
• the solution must be “ophthalmically safe” for use with a lens such as a contact lens, meaning that a contact lens treated with the solution is generally suitable and safe for direct placement on the eye without rinsing, that is, the solution is safe and comfortable for daily contact with the eye via a contact lens that has been wetted with the solution.
• An ophthalmically safe solution has a tonicity and pH that is compatible with the eye and includes materials, and amounts thereof, that are non-cytotoxic according to ISO standards and U.S. Food & Drug Administration (FDA) regulations.
• the solution should be sterile in that the absence of microbial contaminants in the product prior to release must be statistically demonstrated to the degree necessary for such products.
• the liquid media useful in the present invention are selected to have no substantial detrimental effect on the lens being treated or cared for and to allow or even facilitate the present lens treatment or treatments.
• the liquid media are preferably aqueous-based.
• a particularly useful aqueous liquid medium is that derived from saline, for example, a conventional saline solution or a conventional buffered saline solution.
• Suitable buffers may be added, such as: phosphate; borate; citrate; carbonate; tris-(hydroxymethyl)aminomethane (TRIS); bis(2-hydroxyethyl)-imino-tris-(hydroxymethyl)aminoalcohol (bis-tris); zwitterionic buffers such as N-[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine (Tricine)and N-[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine, MOPS; N-(Carbamoylmethyl)taurine (ACES); amino acids and amino acid derivatives; and mixtures thereof.
• TriS tris-(hydroxymethyl)aminomethane
• bis-tris bis(2-hydroxyethyl)-imino-tris-(hydroxymethyl)aminoalcohol
• zwitterionic buffers such as N-[2-Hydroxy-1,1-bis(hydroxymethyl)eth
• buffers will be used in amounts ranging from about 0.05 to about 2.5 percent by weight, and preferably from about 0.1 to about 1.5 percent by weight of the solution.
• the packaging solutions of this invention preferably contain a borate buffer, containing one or more of boric acid, sodium borate, potassium tetraborate, potassium metaborate or mixtures of the same.
• the solutions of the present invention may be adjusted with tonicity agents, to approximate the osmotic pressure of normal lacrimal fluids, which is equivalent to a 0.9 percent solution of sodium chloride or 2.5 percent of glycerol solution.
• the solutions are made substantially isotonic with physiological saline used alone or in combination, otherwise if simply blended with sterile water and made hypotonic or made hypertonic the lenses will lose their desirable optical parameters.
• excess saline may result in the formation of a hypertonic solution, which will cause stinging, and eye irritation.
• Suitable tonicity adjusting agents include, but are not limited to, sodium and potassium chloride, dextrose, calcium and magnesium chloride and the like and mixtures thereof. These agents are typically used individually in amounts ranging from about 0.01 to about 2.5% w/v and preferably from about 0.2 to about 1.5% w/v.
• the tonicity agent will be employed in an amount to provide a final osmotic value of at least about 200 mOsm/kg, preferably from about 200 to about 450 mOsm/kg, more preferably from about 250 to about 400 mOsm/kg, and most preferably from about 280 to about 370 mOsm/kg.
• one or more additional components can be included in the packaging solution.
• Such additional component or components are chosen to impart or provide at least one beneficial or desired property to the packaging solution.
• Such additional components may be selected from components that are conventionally used in one or more ophthalmic device care compositions. Examples of such additional components include cleaning agents, wetting agents, nutrient agents, sequestering agents, viscosity builders, contact lens conditioning agents, antioxidants, and the like and mixtures thereof.
• These additional components may each be included in the packaging solutions in an amount effective to impart or provide the beneficial or desired property to the packaging solutions.
• such additional components may be included in the packaging solutions in amounts similar to the amounts of such components used in other, e.g., conventional, contact lens care products.
• Useful sequestering agents include, but are not limited to, disodium ethylene diamine tetraacetate, alkali metal hexametaphosphate, citric acid, sodium citrate and the like and mixtures thereof.
• Useful antioxidants include, but are not limited to, sodium metabisulfite, sodium thiosulfate, N-acetylcysteine, butylated hydroxyanisole, butylated hydroxytoluene and the like and mixtures thereof.
• the method of packaging and storing an ophthalmic lens according to the present invention includes at least packaging the ophthalmic lens immersed in the aqueous contact lens packaging solution described above.
• the method may include immersing the ophthalmic lens in an aqueous contact lens solution prior to delivery to the customer/wearer, directly following manufacture of the contact lens.
• the packaging and storing in the solution of the present invention may occur at an intermediate point before delivery to the ultimate customer (wearer) but following manufacture and transportation of the lens in a dry state, wherein the dry lens is hydrated by immersing the lens in the contact lens packaging solution. Consequently, a package for delivery to a customer may include a sealed container containing one or more unused contact lenses immersed in an aqueous contact lens packaging solution according to the present invention.
• the steps leading to the present ophthalmic device packaging system include (1) molding an ophthalmic device in a mold comprising at least a first and second mold portion, (2) removing the lens from the mold portions; (3) introducing the packing solution of this invention and the ophthalmic lens into the container, and (4) sealing the container.
• the method also includes the step of sterilizing the contents of the container. Sterilization may take place prior to, or most conveniently after, sealing of the container and may be effected by any suitable method known in the art, e.g., by balanced autoclaving of the sealed container at temperatures of about 120° C. or higher.
• Preferred packages are plastic blister packages, including a recess for receiving a contact lens and the package solution, where the recess is sealed with lidstock prior to sterilization of the package contents.
• Tables 1 to 3 illustrate various solutions of this invention. Additionally, the pH of the solutions in Tables 2 and 3 was adjusted with NaOH/HCl.
• Tables 4 and 5 list other solutions of this invention, as well as two comparative solutions.
• Tables 4 and 5 were tested as follows. Contact lenses were soaked in the respective solutions of Tables 4 and 5 for no fewer than 72 hours. Lenses were then removed from the test solution and were immediately mounted and tested in 1 mL phosphate borate saline (PBS). Tribological testing was performed on a CETR Model UMT-2 micro-tribometer. Each lens was clamped on an HDPE holder that initially mates with the posterior side of the lens. A poly(propylene) clamping ring was then used to hold the edge region of the lens. Once the lens was mounted in the holder the assembly was placed in a stationary clamping device within the micro-tribometer.
• PBS phosphate borate saline
• Tribology is the study of how two surfaces interact with each other when in relative motion.
• One aspect of tribology that may be of importance to contact lenses is friction.
• Friction is a measure of a material's resistance to lateral motion when placed against a specific substrate.
• the relative friction between two surfaces may be described in terms of a coefficient of friction (COF), which is defined as the ratio of the lateral force (F x ) that is required to initiate and then sustain movement to the normal force (F N ).
• COF coefficient of friction
• the static COF is a measure of how much F x is needed to initiate relative motion of two surfaces and is typically the larger of the two values.
• the static COF is related to the amount of force needed to start a blink cycle or for the lens to begin moving over the cornea.
• the kinetic COF is a measure of how much lateral force is needed to sustain movement at a particular velocity averaged over a finite period of time. This value is related to the amount of force required to sustain the blink over the course of the entire cycle and the ease of motion of the lens on the cornea (which may be further related to how much the lens moves on the cornea).

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• 2006
  • 2006-11-10 US US11/595,616 patent/US20080110770A1/en not_active Abandoned
• 2007
  • 2007-10-17 EP EP07854129A patent/EP2102324B1/en not_active Revoked
  • 2007-10-17 JP JP2009536374A patent/JP2010508980A/ja active Pending
  • 2007-10-17 ES ES07854129T patent/ES2364296T3/es active Active
  • 2007-10-17 CN CNA2007800416674A patent/CN101535461A/zh active Pending
  • 2007-10-17 WO PCT/US2007/081630 patent/WO2008060798A1/en active Application Filing
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