US20070276609A1 - System and method of assessing analgesic adequacy using biopotential variability - Google Patents

System and method of assessing analgesic adequacy using biopotential variability Download PDF

Info

Publication number
US20070276609A1
US20070276609A1 US11/731,510 US73151007A US2007276609A1 US 20070276609 A1 US20070276609 A1 US 20070276609A1 US 73151007 A US73151007 A US 73151007A US 2007276609 A1 US2007276609 A1 US 2007276609A1
Authority
US
United States
Prior art keywords
subject
measure
analgesic
metric
adequacy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11/731,510
Other languages
English (en)
Inventor
Scott Greenwald
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nellcor Puritan Bennett LLC
Original Assignee
Aspect Medical Systems LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38564266&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20070276609(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aspect Medical Systems LLC filed Critical Aspect Medical Systems LLC
Priority to US11/731,510 priority Critical patent/US20070276609A1/en
Assigned to ASPECT MEDICAL SYSTEMS, INC. reassignment ASPECT MEDICAL SYSTEMS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: GREENWALD, SCOTT D.
Publication of US20070276609A1 publication Critical patent/US20070276609A1/en
Assigned to ASPECT MEDICAL SYSTEMS, LLC reassignment ASPECT MEDICAL SYSTEMS, LLC MERGER (SEE DOCUMENT FOR DETAILS). Assignors: ASPECT MEDICAL SYSTEMS, INC.
Assigned to NELLCOR PURITAN BENNETT LLC reassignment NELLCOR PURITAN BENNETT LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ASPECT MEDICAL SYSTEMS, LLC
Priority to US13/159,459 priority patent/US8538705B2/en
Priority to US14/020,740 priority patent/US20140012153A1/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4821—Determining level or depth of anaesthesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A61B5/372—Analysis of electroencephalograms
    • A61B5/374—Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/389—Electromyography [EMG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/389—Electromyography [EMG]
    • A61B5/397—Analysis of electromyograms

Definitions

  • the anesthetic administration is complicated by the multiple effects of the administered anesthetic agents.
  • volatile agents have analgesic as well as sedative effects
  • an increase in the administered concentration of a volatile agent will result in a concomitant, and possibly undesired, increase in analgesic effect.
  • All anesthetic agents have deleterious effects associated with excessive doses. While the effect on the patient may be estimated from the administered dose, patients vary widely in their response to a specific dose and such estimates are therefore based upon group norms (average effects). While the group norm may be representative of the effect of a specific dose on a population of patients, the actual effect in any one patient may vary widely.
  • the CVM Index In order to reduce the variation of the trended (time series) of the CVM Index, the change from sample to sample, it may be desirable to smooth the CVM Index. This may be accomplished by averaging some number of the most recent CVM Index values, with larger number of values being averaged together to provide a smoother and slower response, or fewer number of values being averaged together to provide a more variable and faster response. Such averaging may be equally weighted or weighted in a manner in which the influence of each CVM Index value in the average varies depending upon some weighting function.
  • An example of such a weighting function is an inverse age function, in which the individual CVM Index values are weighted (multiplied) by the inverse of there age. This technique has the effect of weighting the most recent CVM Index values more strongly than older ones.
  • smoothing is not applied, since the temporal averaging inherent in the calculation of BIS and EMG provides adequate smoothing.
  • the consciousness monitors manufactured by Aspect Medical Systems generate a variable called Suppression Ratio (SR) which quantifies the degree to which the EEG waveform is suppressed.
  • SR Suppression Ratio
  • the preferred embodiment of the invention does not calculate a value for the CVM Index when the value of SR rises above a threshold, preferably 40.
  • FIG. 4 The analysis of the pain scores ranked by quintiles is shown in FIG. 4 .
  • Graph A in FIG. 4 shows a rank-ordered increase in the SD of BIS with increased pain score. The increase of SD of BIS is consistent across the range of pain scores.
  • Graph B in FIG. 4 shows the relationship between the SD of EMG and pain score. While there is essentially no difference in the SD of EMG at the two lowest pain scores (1 and 2), there is a rapid rank-ordered increase with pain scores 3-5.
  • Graph C in FIG. 4 shows the relationship of the CVM Index to postoperative the pain score. The combination of the SD of both BIS and EMG in the CVM Index results in a consistent rank-ordered increase across pain scores.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
US11/731,510 2006-03-31 2007-03-30 System and method of assessing analgesic adequacy using biopotential variability Abandoned US20070276609A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US11/731,510 US20070276609A1 (en) 2006-03-31 2007-03-30 System and method of assessing analgesic adequacy using biopotential variability
US13/159,459 US8538705B2 (en) 2006-03-31 2011-06-14 System and method of assessing analgesic adequacy using biopotential variability
US14/020,740 US20140012153A1 (en) 2006-03-31 2013-09-06 System and method of assessing analgesic adequacy using biopotential variability

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78799206P 2006-03-31 2006-03-31
US11/731,510 US20070276609A1 (en) 2006-03-31 2007-03-30 System and method of assessing analgesic adequacy using biopotential variability

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/159,459 Continuation US8538705B2 (en) 2006-03-31 2011-06-14 System and method of assessing analgesic adequacy using biopotential variability

Publications (1)

Publication Number Publication Date
US20070276609A1 true US20070276609A1 (en) 2007-11-29

Family

ID=38564266

Family Applications (3)

Application Number Title Priority Date Filing Date
US11/731,510 Abandoned US20070276609A1 (en) 2006-03-31 2007-03-30 System and method of assessing analgesic adequacy using biopotential variability
US13/159,459 Active 2027-04-14 US8538705B2 (en) 2006-03-31 2011-06-14 System and method of assessing analgesic adequacy using biopotential variability
US14/020,740 Abandoned US20140012153A1 (en) 2006-03-31 2013-09-06 System and method of assessing analgesic adequacy using biopotential variability

Family Applications After (2)

Application Number Title Priority Date Filing Date
US13/159,459 Active 2027-04-14 US8538705B2 (en) 2006-03-31 2011-06-14 System and method of assessing analgesic adequacy using biopotential variability
US14/020,740 Abandoned US20140012153A1 (en) 2006-03-31 2013-09-06 System and method of assessing analgesic adequacy using biopotential variability

Country Status (9)

Country Link
US (3) US20070276609A1 (ja)
EP (1) EP2007279B1 (ja)
JP (1) JP5108870B2 (ja)
CN (1) CN101426422A (ja)
AU (1) AU2007233071B2 (ja)
BR (1) BRPI0710104A2 (ja)
CA (1) CA2647729A1 (ja)
MX (1) MX2008012591A (ja)
WO (1) WO2007115215A2 (ja)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080249431A1 (en) * 2006-09-29 2008-10-09 The Regents Of The University Of California Burst suppression monitor for induced coma
US20080249430A1 (en) * 2007-04-05 2008-10-09 Erwin Roy John System and Method for Pain Detection and Computation of a Pain Quantification Index
US20110295196A1 (en) * 2009-01-15 2011-12-01 Hopital Foch System for controlling means for injection of anesthetics or sedatives
US8731652B2 (en) 2008-03-17 2014-05-20 Med Storm Innovation As Method and apparatus for monitoring the autonomous nervous system of a sedated patient
US10537677B2 (en) 2009-01-15 2020-01-21 Medsteer System for controlling injectors of anaesthetics or sedatives with a view to inducing anaesthesia or sedation
US11273283B2 (en) 2017-12-31 2022-03-15 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to enhance emotional response
US11317858B2 (en) * 2016-09-05 2022-05-03 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. Medical monitoring device and method and system for displaying patient monitoring information
US11364361B2 (en) 2018-04-20 2022-06-21 Neuroenhancement Lab, LLC System and method for inducing sleep by transplanting mental states
US11452839B2 (en) 2018-09-14 2022-09-27 Neuroenhancement Lab, LLC System and method of improving sleep
US11717686B2 (en) 2017-12-04 2023-08-08 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to facilitate learning and performance
US11723579B2 (en) 2017-09-19 2023-08-15 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement
US11786694B2 (en) 2019-05-24 2023-10-17 NeuroLight, Inc. Device, method, and app for facilitating sleep

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0622512D0 (en) * 2006-11-13 2006-12-20 Wenman Alan Depth of anaesthesia and analgesia
JP2009261779A (ja) * 2008-04-28 2009-11-12 Univ Of Electro-Communications 痛み評価方法及び痛み評価装置
US9326725B2 (en) 2010-03-30 2016-05-03 Children's National Medical Center Apparatus and method for human algometry
EP2621333B1 (en) 2010-09-28 2015-07-29 Masimo Corporation Depth of consciousness monitor including oximeter
US20140303453A1 (en) * 2011-07-06 2014-10-09 Ontario Hospital Research Institute System and Method for Generating Composite Measures of Variability
CN103169466B (zh) * 2013-04-01 2015-07-22 张宇奇 一种用于麻醉的痛觉监护系统及监护方法
US9849241B2 (en) 2013-04-24 2017-12-26 Fresenius Kabi Deutschland Gmbh Method of operating a control device for controlling an infusion device
EP2799009A1 (en) * 2013-04-29 2014-11-05 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Non-invasive method for prediction of opioid-analgesia and opioid-blood-concentrations
US9239619B2 (en) * 2013-11-08 2016-01-19 Applied Invention, Llc Use of light transmission through tissue to detect force
US9955894B2 (en) 2014-01-28 2018-05-01 Covidien Lp Non-stationary feature relationship parameters for awareness monitoring
WO2016057553A1 (en) 2014-10-07 2016-04-14 Masimo Corporation Modular physiological sensors
US10835144B2 (en) * 2014-10-22 2020-11-17 Ekg Technology Lab, Inc. Electroencephalograph, brain wave measurement method, brain wave measurement system
EP3232917B1 (en) * 2014-12-18 2019-09-18 Quantium Medical S.L. Apparatus for the assessment of the level of pain and nociception during general anesthesia using electroencephalogram, plethysmographic impedance cardiography, heart rate variability and the concentration or biophase of the analgesics
CN106200975B (zh) * 2016-07-15 2019-06-21 广州视源电子科技股份有限公司 一种生物反馈放松方法及装置
CN115279258A (zh) * 2020-01-16 2022-11-01 布洛里拉私人有限公司 用于检测和分类从eeg记录中获得的信号段的方法和系统
CN112244870B (zh) * 2020-09-24 2022-02-22 杭州电子科技大学 基于符号化排列传递熵的癫痫脑电双向耦合分析方法
CN113499035B (zh) * 2021-07-12 2023-09-05 扬州大学 一种基于置信区间融合阈值判据的疼痛识别系统

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6934579B2 (en) * 1996-09-11 2005-08-23 The University Court Of The University Of Glasgow Anaesthesia control system

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5010891A (en) * 1987-10-09 1991-04-30 Biometrak Corporation Cerebral biopotential analysis system and method
JPH03136408A (ja) 1989-10-23 1991-06-11 Fujitsu Ten Ltd 音質制御装置
US5458117A (en) * 1991-10-25 1995-10-17 Aspect Medical Systems, Inc. Cerebral biopotential analysis system and method
US5601090A (en) 1994-07-12 1997-02-11 Brain Functions Laboratory, Inc. Method and apparatus for automatically determining somatic state
US6117075A (en) 1998-09-21 2000-09-12 Meduck Ltd. Depth of anesthesia monitor
US6757558B2 (en) 2000-07-06 2004-06-29 Algodyne, Ltd. Objective pain measurement system and method
US6801803B2 (en) 2000-10-16 2004-10-05 Instrumentarium Corp. Method and apparatus for determining the cerebral state of a patient with fast response
US6731975B1 (en) 2000-10-16 2004-05-04 Instrumentarium Corp. Method and apparatus for determining the cerebral state of a patient with fast response
US20040015091A1 (en) 2002-04-01 2004-01-22 Aspect Medical Systems System and method of assessment of arousal, pain and stress during anesthesia and sedation
JP2006514570A (ja) 2003-05-06 2006-05-11 エヴェレスト バイオメディカル インストルメンツ 麻酔および鎮静監視のシステムおよび方法
US7367949B2 (en) 2003-07-07 2008-05-06 Instrumentarium Corp. Method and apparatus based on combination of physiological parameters for assessment of analgesia during anesthesia or sedation
US7215994B2 (en) * 2004-02-17 2007-05-08 Instrumentarium Corporation Monitoring the neurological state of a patient
US7447541B2 (en) * 2004-06-30 2008-11-04 Instrumentarium Corporation Monitoring subcortical responsiveness of a patient
US7925338B2 (en) 2005-03-24 2011-04-12 General Electric Company Determination of the anesthetic state of a patient
US20070167694A1 (en) 2005-12-21 2007-07-19 Everest Biomedical Instruments Co. Integrated Portable Anesthesia and Sedation Monitoring Apparatus

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6934579B2 (en) * 1996-09-11 2005-08-23 The University Court Of The University Of Glasgow Anaesthesia control system

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080249431A1 (en) * 2006-09-29 2008-10-09 The Regents Of The University Of California Burst suppression monitor for induced coma
US8649855B2 (en) * 2006-09-29 2014-02-11 The Regents Of The University Of California Burst suppression monitor for induced coma
US9597006B2 (en) 2006-09-29 2017-03-21 The Regents Of The University Of California Burst suppression monitor for induced coma
US9402558B2 (en) * 2007-04-05 2016-08-02 New York University System and method for pain detection and computation of a pain quantification index
US20080249430A1 (en) * 2007-04-05 2008-10-09 Erwin Roy John System and Method for Pain Detection and Computation of a Pain Quantification Index
US8731652B2 (en) 2008-03-17 2014-05-20 Med Storm Innovation As Method and apparatus for monitoring the autonomous nervous system of a sedated patient
US10537677B2 (en) 2009-01-15 2020-01-21 Medsteer System for controlling injectors of anaesthetics or sedatives with a view to inducing anaesthesia or sedation
US8864702B2 (en) * 2009-01-15 2014-10-21 Hopital Foch System for controlling means for injection of anesthetics or sedatives
US20110295196A1 (en) * 2009-01-15 2011-12-01 Hopital Foch System for controlling means for injection of anesthetics or sedatives
US11317858B2 (en) * 2016-09-05 2022-05-03 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. Medical monitoring device and method and system for displaying patient monitoring information
US11723579B2 (en) 2017-09-19 2023-08-15 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement
US11717686B2 (en) 2017-12-04 2023-08-08 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to facilitate learning and performance
US11273283B2 (en) 2017-12-31 2022-03-15 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to enhance emotional response
US11318277B2 (en) 2017-12-31 2022-05-03 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to enhance emotional response
US11478603B2 (en) 2017-12-31 2022-10-25 Neuroenhancement Lab, LLC Method and apparatus for neuroenhancement to enhance emotional response
US11364361B2 (en) 2018-04-20 2022-06-21 Neuroenhancement Lab, LLC System and method for inducing sleep by transplanting mental states
US11452839B2 (en) 2018-09-14 2022-09-27 Neuroenhancement Lab, LLC System and method of improving sleep
US11786694B2 (en) 2019-05-24 2023-10-17 NeuroLight, Inc. Device, method, and app for facilitating sleep

Also Published As

Publication number Publication date
EP2007279A2 (en) 2008-12-31
EP2007279A4 (en) 2011-10-19
US20140012153A1 (en) 2014-01-09
AU2007233071A1 (en) 2007-10-11
WO2007115215A3 (en) 2008-04-24
US8538705B2 (en) 2013-09-17
MX2008012591A (es) 2008-10-10
WO2007115215A2 (en) 2007-10-11
US20110245709A1 (en) 2011-10-06
JP5108870B2 (ja) 2012-12-26
JP2009532130A (ja) 2009-09-10
CN101426422A (zh) 2009-05-06
CA2647729A1 (en) 2007-10-11
AU2007233071B2 (en) 2013-09-26
BRPI0710104A2 (pt) 2011-08-02
EP2007279B1 (en) 2015-02-25

Similar Documents

Publication Publication Date Title
US8538705B2 (en) System and method of assessing analgesic adequacy using biopotential variability
Kane et al. A revised glossary of terms most commonly used by clinical electroencephalographers and updated proposal for the report format of the EEG findings. Revision 2017
US6801803B2 (en) Method and apparatus for determining the cerebral state of a patient with fast response
US7228169B2 (en) Method and apparatus for determining the cerebral state of a patient with fast response
EP1495715B1 (en) A method and apparatus based on combination of three phsysiological parameters for assessment of analgesia during anesthesia or sedation
EP1757226B1 (en) Measurement of responsiveness of a patient under anaesthesia
EP1665981A1 (en) Identification of a dominant signal component in a biosignal
CN107530023B (zh) 用于脑电图检查的装置和方法
Pomfrett et al. Respiratory sinus arrhythmia: an index of light anaesthesia
Sinha et al. Monitoring devices for measuring the depth of anaesthesia–An overview
WO2014091291A1 (en) A device and method for determining the probability of response to pain and nociception of a subject t
Rabbani et al. Estimation the depth of anesthesia by the use of artificial neural network
Telser et al. Temporally resolved fluctuation analysis of sleep ECG
Kennedy et al. Monitoring techniques: neuromuscular blockade and depth of anaesthesia
Agarwal et al. Monitoring the depth of anaesthesia
Kangas et al. Neurometric assessment of adequacy of intraoperative anesthetic
EP1859733A1 (de) Verfahren und Vorrichtung zur Korrelation von Signalen der Atmung des Herz-Kreislauf-Systems
Imhoff Correlation between the EEG monitors BIS and State entropy and their performance in differentiate consciousness and unconsciousness-an EEG Reanalysis
Ryser Movement-based sleep detection–a wearable sensor system to assess quantity and quality of sleep
Nguyen-Ky Monitoring the depth of anaesthesia using simplified electroencephalogram (EEG)
Melia et al. Signal Analysis and Response Measurement

Legal Events

Date Code Title Description
AS Assignment

Owner name: ASPECT MEDICAL SYSTEMS, INC., MASSACHUSETTS

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:GREENWALD, SCOTT D.;REEL/FRAME:019648/0934

Effective date: 20070730

AS Assignment

Owner name: ASPECT MEDICAL SYSTEMS, LLC, MASSACHUSETTS

Free format text: MERGER;ASSIGNOR:ASPECT MEDICAL SYSTEMS, INC.;REEL/FRAME:023758/0188

Effective date: 20091223

Owner name: NELLCOR PURITAN BENNETT LLC, MISSOURI

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ASPECT MEDICAL SYSTEMS, LLC;REEL/FRAME:023761/0707

Effective date: 20091225

Owner name: ASPECT MEDICAL SYSTEMS, LLC,MASSACHUSETTS

Free format text: MERGER;ASSIGNOR:ASPECT MEDICAL SYSTEMS, INC.;REEL/FRAME:023758/0188

Effective date: 20091223

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION