US20050208454A1 - Arrangement for using osteoinductive or bioactive material to induce bone and/or increase the stability of implants in the jaw bone, and an implant intended for this purpose - Google Patents

Arrangement for using osteoinductive or bioactive material to induce bone and/or increase the stability of implants in the jaw bone, and an implant intended for this purpose Download PDF

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Publication number
US20050208454A1
US20050208454A1 US10/521,743 US52174305A US2005208454A1 US 20050208454 A1 US20050208454 A1 US 20050208454A1 US 52174305 A US52174305 A US 52174305A US 2005208454 A1 US2005208454 A1 US 2005208454A1
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Prior art keywords
implant
bone
growth
hole
parts
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Abandoned
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US10/521,743
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English (en)
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Jan Hall
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Nobel Biocare Services AG
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Nobel Biocare AB
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Assigned to NOBEL BIOCARE AB (PUBL.) reassignment NOBEL BIOCARE AB (PUBL.) ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HALL, JAN
Publication of US20050208454A1 publication Critical patent/US20050208454A1/en
Priority to US12/210,899 priority Critical patent/US8167618B2/en
Assigned to NOBEL BIOCARE SERVICES AG reassignment NOBEL BIOCARE SERVICES AG ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: NOBEL BIOCARE AB
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0003—Not used, see subgroups
    • A61C8/0009—Consolidating prostheses or implants, e.g. by means of stabilising pins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors

Definitions

  • the present invention relates to an arrangement for using osteoinductive material to induce bone and/or increase the stability of implants applied in jaw bone holes which have been created by tooth root extraction.
  • the implant In an initial stage, the implant is anchored or fitted in the hole via its inner parts, and with its outer parts it extends into a part of the hole which has a cross-sectional area exceeding the cross-sectional area of the outer parts of the implant.
  • the outer parts of the hole, the implant and the soft tissue of the jaw bone, with or without periosteum, constitute a closed space at said outer parts.
  • the invention also relates to a use in a jaw bone hole created by tooth root extraction which has given the hole a cross-sectional area at the outer parts of the hole which exceeds the cross-sectional area of the hole at its inner parts.
  • the invention also relates to an implant which can be fitted in a jaw bone hole created by tooth root extraction and arranged with its outer parts extending into a part of the hole which has a cross-sectional area exceeding the cross-sectional area of the outer parts.
  • inner and outer parts refer to the locations in the longitudinal direction, i.e. the inner parts are located farthest into the jaw bone, and the outer parts are situated at outer parts of the jaw bone. Said terms thus do not relate, for example, to parts of the implant lying on the outside or on the inside.
  • substrates of various types for example substrate in the form of autologous bone, allogenic bone, xenografts, or synthetic material, for example in the form of or comprising calcium phosphates (e.g. hydroxylapatite).
  • substrates for example substrate in the form of autologous bone, allogenic bone, xenografts, or synthetic material, for example in the form of or comprising calcium phosphates (e.g. hydroxylapatite).
  • the space thus filled with substrate is sewn closed or covered over with the soft tissue, possibly in combination with some form of covering membrane.
  • a characteristic of the substrate is that it is resorbable to a greater or lesser extent and is gradually replaced by bone. Doses of different substrates are available on the market from a number of companies operating on the market. Reference is made quite generally to these known substrates.
  • the present invention aims to solve these problems among others and proposes a novel use of implants which in one embodiment can be of a type known per se.
  • the implants are in this case of the type which in some way or another has been provided with growth-stimulating substance(s) (GSS) which in a known manner is/are able to generate new bone, i.e. in this case jaw bone, in cooperation with cells, for example stem cells, which are found in the body and occur for example in body fluid formed in the cavities of the body which have been subjected to an intervention, for example in the form of tooth extraction.
  • GSS growth-stimulating substance(s)
  • stem cells which are found in the body and occur for example in body fluid formed in the cavities of the body which have been subjected to an intervention, for example in the form of tooth extraction.
  • the bioactive material consists of GSS arranged on or in the implant, for example on its outer surface or outer thread, at its outer parts.
  • said GSS passes outward into body fluid which has penetrated or is penetrating from the surrounding tissue and periosteum into the aforementioned closed space and interacts with cells present in the fluid, which leads to formation of new bone around said outer parts of the implant.
  • GSS can be arranged in principle only at or on said outer parts of the implant.
  • GSS can also be arranged as one or more layers lying on the outside of the implant's outer part or outer thread.
  • GSS can also be arranged together with one or more layers of, for example, calcium phosphate (s).
  • the implant can be provided in a manner known per se with a reservoir function for GSS, and this can consist of porous outer layers and/or oxide layers arranged at least at said outer parts of the implant.
  • GSS can also be combined with bone substitute of known type, which can be applied as layers directly on the surface or thread.
  • the feature which can principally be regarded as characterizing a use according to the invention is that, for new production of bone in a space closed with periosteum between an implant and the wall of the hole in the jaw bone, use is made of GSS grafted onto the outer parts of the implant and passing outward into cell-containing body fluid which penetrates or has penetrated into the space.
  • implants there is a need to be able to abandon the conventional production methods for implants and instead be able to cast or mill these from a blank.
  • the implant must be able to have a shape corresponding to the jaw bone hole in question, so that it is possible to anchor the implant without having to use threads, for example, in the implant and jaw bone.
  • the invention also solves this problem.
  • an implant which can principally be regarded as characterizing an implant according to the invention is, inter alia, that it is provided with growth-stimulating substance(s) (GSS) interacting with cells in body fluid so that new bone is formed.
  • GSS growth-stimulating substance(s)
  • the implant can have its inner parts configured as tooth root shapes. Further developments of the implant are set out in the attached dependent claims.
  • the presently practiced or proposed technique for applying GSS to implants can be used advantageously and in this way the front line of the new technique can be pushed forward considerably.
  • the GSS used can be matrix molecules, growth factors, differentiation factors, peptides with growth-stimulating properties, etc.
  • FIG. 1 shows a vertical view of a tooth in a jaw bone with soft tissue, which tooth is intended to be removed in its entirety in a manner known per se, i.e. together with its tooth root part,
  • FIG. 2 shows a vertical section of a jaw bone hole present after extraction of the tooth according to FIG. 1 , in which an implant has been fitted, and the soft tissue has been pulled over the implant and a space between the implant and the jaw bone hole,
  • FIG. 3 shows an enlarged vertical view of parts of the implant, the jaw bone and the soft tissue according to FIG. 2 , and where GSS is released from the outer parts of the implant and body fluid with cells, for example stem cells, is released from the jaw bone and the periosteum lying under the soft tissue,
  • GSS is released from the outer parts of the implant and body fluid with cells, for example stem cells, is released from the jaw bone and the periosteum lying under the soft tissue
  • FIG. 4 shows a vertical view of bone newly formed by GSS in the space between the implant and the jaw bone, and parts of the soft tissue, and
  • FIGS. 5-7 show diagrammatically, in vertical views, different configurations of the jaw bone hole and the implant at the inner parts, and the principle of production of the implants.
  • a tooth is shown symbolically by 1 .
  • the tooth is fitted in a jaw bone 2 which at its top surface is provided with soft tissue (gingiva) 3 ′ and periosteum 3 , which are indicated symbolically.
  • the figure also indicates, with 1 a , the part of the tooth projecting above the soft tissue 3 ′.
  • the tooth root is shown by 1 b.
  • reference number 4 indicates a jaw bone hole which is present when the tooth according to FIG. 1 has been completely extracted, i.e. with the root 1 b and all.
  • the shape of the jaw bone hole largely follows the shape of the tooth 1 (see FIG. 1 ) in the jaw bone.
  • the hole thus has a widened part 4 a at its outer parts and a relatively narrow part 4 b at its inner parts.
  • the hole's appearance thus varies as a function of the tooth which is to be extracted, but a characteristic of the jaw bone hole is that it is narrower at its inner parts 4 b than at its outer parts 4 a .
  • an implant 5 has been fitted in the jaw bone hole.
  • the implant has outer parts 5 a , meaning those parts which are situated farthest outward in relation to the dentine.
  • the implant has inner parts 5 b , representing those parts situated farthest into the dentine 2 .
  • the implant has a diameter D which, at the inner parts 5 b , exceeds the diameter d of the jaw bone hole.
  • the implant can be of a type known per se and can, for example, be of the self-tapping type, cf. the implants sold on the market by Nobel Biocare.
  • the implant is tapered at said inner parts 5 b , although this is not specifically indicated in FIG. 2 .
  • the tapered part at the end of the implant also exceeds said diameter d.
  • the implant's diameter D′ is smaller than the diameter d′ of the jaw bone hole.
  • the jaw bone hole thus widens outward/upward (in the figure) and can have a cone shape along parts or all of its length.
  • the space between the outer surface or outer thread 5 a ′ of the implant and the wall 4 a ′ of the jaw bone hole is considerable.
  • the cross-sectional area of the jaw bone hole can assume twice the diameter of the cross-sectional area of the implant.
  • a closed space 4 a will be present between the outer surface 5 a ′ of the implant and the hole wall 4 a ′ and an underside or bottom surface of part of the soft tissue, with or without periosteum, which is drawn over the space and the implant and sewn together, for example, so that the soft tissue and possibly the periosteum 3 a , if present, cover the implant and the space, and in this way a closed space 4 a is formed.
  • periosteum 3 a is assumed to be present under the soft tissue and its bottom surface is indicated by 3 a ′.
  • at least that part of the implant (its outer parts) located in the closed space 4 a is provided with grafted GSS in accordance with what is described below.
  • FIG. 3 shows how GSS 6 is released from the implant surface and passes outward into the space 4 a .
  • Directional arrows for this are indicated by 6 a .
  • body fluid collects in the space 4 a .
  • Cells for example stem cells from the lower surface 3 a ′ of the periosteum, are indicted by the arrows 7 , and cells from the jaw bone 2 are indicated by the arrows 8 .
  • the accumulation of body fluid is symbolized by 9 .
  • the body fluid contains cells with which the GSS interacts, so that new bone is formed in the space 4 a . This process depends on the amount of GSS on the implant surface parts, the amount and type of cells, and the size of the space 4 a , i.e. the amount of body fluid.
  • the periosteum is a source of stem cells which greatly stimulate said formation of new bone in the case where GSS consists of differentiation factors such as bone morphogenetic proteins (BMP).
  • BMP bone morphogenetic proteins
  • FIG. 4 shows the situation where the process of new bone formation, i.e. the process of incorporation of the implant, is completed.
  • the newly formed bone in principle fills the entire space 4 a .
  • the implant 5 has been provided with a diagrammatically indicated attachment 11 for a dental fixture which in principle can replace the upper part 1 a of the extracted tooth, cf. FIG. 1 .
  • the fitting operation can be carried out in a manner known per se.
  • the soft tissue with periosteum 3 ′, 3 has been attached to an outer surface 11 a of the fixture and bears via a part 3 b against the outer surface 11 a in question.
  • an implant known per se can be used in the tooth replacement function.
  • An implant which in a known manner or a novel manner is provided with grafted or otherwise applied GSS is used in the jaw bone hole in question.
  • the implant can be screwed into the hole using the self-tapping principle.
  • the hole can be threaded to match an implant. This pre-threading can also take place in a manner known per se.
  • the newly formed bone contributes to strong stabilization of the implant in the jaw bone hole.
  • the amount of GSS can in this case be related to the volume of the closed space, the clinical situation and/or the tooth which is to be replaced with the implant/dental construction, etc.
  • the hole around the implant can be covered with a membrane or a protective part of a type known per se.
  • the implant is preferably made of titanium but can consist of another biocompatible material, for example ceramic.
  • a jaw bone is indicated diagrammatically by 12 .
  • a tooth in the jaw bone is indicated by 13 and the tooth is in this case of the type which has two root parts 13 a and 13 b .
  • the tooth extends in the jaw bone hole 14 which is shown with an overdimensioned gap for reasons of clarity.
  • the tooth can be extracted from the jaw bone in the direction of arrow 15 .
  • FIG. 5 shows an alternative design of the tooth root.
  • FIG. 6 shows the lower parts of a tooth 16 provided with three root parts 17 , 18 and 19 .
  • the jaw bone is in this case indicated by 12 ′.
  • the tooth 16 in question can be extracted from the jaw bone in the direction of arrow 20 .
  • the hole 21 in the jaw bone for this tooth is shown with an overdimensioned gap for reasons of clarity.
  • an appliance 22 is used to define or image the jaw bone hole 14 in FIG. 5 when the tooth 13 has been extracted.
  • An imaging technique known per se can be used, for example X-ray, computed tomography, etc.
  • the appliance 22 the surgeon, the dentist or other person performing treatment is given an image of the shape of the jaw bone hole 14 .
  • the shape is assigned a representation in an appliance 23 which can be part of a computer installation known per se. The representation is symbolized by 24 and can be used as a basis for production of an implant 25 which is intended to be placed in the jaw bone hole 14 in question (see FIGS.
  • the fitting operation can be carried out in such a way that the implant can be applied with relatively little clearance in the jaw bone hole.
  • the implant 25 has a design which, upon application of the implant in the jaw bone hole, means that the hole wall springs aside and then back to a position corresponding tQ the position of the tooth 13 in FIG. 5 .
  • the implant can be made to some extent resilient in those parts which upon application are intended to match narrowing parts in the jaw bone hole.
  • the inner parts of the tooth root extend in such a way that they together have cross-sectional areas which are smaller than the cross-sectional area or cross-sectional areas of above parts of the jaw bone hole.
  • the implant 25 in question can be produced using production equipment 26 of the PROCERA type.
  • the implant can be milled, cast, or produced in some other way.
  • the implant can be given an optimum geometric configuration so that the load on the implant is correctly distributed.
  • the line of the jaw bone hole can be acted upon using tools, for example drilling tools, so that wider parts situated at the bottom can easily match passages in the hole which have been narrower from the start.
  • tools for example drilling tools
  • FIG. 5 such working is indicated by 27 .
  • the space initiated in this way by the recessing or working 27 around the fitted implant can be used as a closed space for new bone formation in accordance with what has been described above.
  • Such working of jaw bone holes can be carried out in different ways from case to case.
  • FIG. 5 a shows an alternative double root configuration.
  • the sides of the jaw bone hole have been worked twice at 27 ′ and 27 ′′, and the area between the original positions of the two roots has been worked at 28 .
  • the space 28 can be used as a closed space for new bone formation.
  • the spaces 28 ′ and 28 ′′ have been formed at the lower parts of the tooth root.
  • these spaces 28 ′ and 28 ′′ can be used as closed spaces for new bone formation.
  • said working can allow the tooth roots belonging to the tooth in question to be simulated to a very high degree when producing the implant in question, i.e. the implant 25 in FIG. 7 .
  • the root formations according to FIGS. 5 a and 6 can also be completed in a relatively simple manner with working(s) 27 ′, 27 ′′ and 29 , 29 ′, respectively, permitting application of an implant with a configuration which corresponds to the design of the tooth root arrangement according to FIGS. 5 a and 6 .
  • the space 29 is also used as a closed space for new bone formation.
  • GSS can be applied in a known manner as a thin skin (a few nanometers thick) on the actual outer surface.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dentistry (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Ceramic Engineering (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
US10/521,743 2002-07-25 2003-06-26 Arrangement for using osteoinductive or bioactive material to induce bone and/or increase the stability of implants in the jaw bone, and an implant intended for this purpose Abandoned US20050208454A1 (en)

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US12/210,899 US8167618B2 (en) 2002-07-25 2008-09-15 Arrangement for using osteoinductive or bioactive material to induce bone and/or increase the stability of implants in the jaw bone, and an implant intended for this purpose

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SE0202315-8 2002-07-25
SE0202315A SE523024C2 (sv) 2002-07-25 2002-07-25 Anordning för att medelst beninduktivt eller bioaktivt medel inducera ben och/eller öka stabiliteten för implantat i käkben samt implantat härför
PCT/SE2003/001106 WO2004010887A1 (en) 2002-07-25 2003-06-26 Arrangement for using osteoinductive or bioactive material to induce bone and/or increase the stability of implants in the jaw bone, and an implant intended for this purpose.

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US12/210,899 Division US8167618B2 (en) 2002-07-25 2008-09-15 Arrangement for using osteoinductive or bioactive material to induce bone and/or increase the stability of implants in the jaw bone, and an implant intended for this purpose

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US12/210,899 Expired - Fee Related US8167618B2 (en) 2002-07-25 2008-09-15 Arrangement for using osteoinductive or bioactive material to induce bone and/or increase the stability of implants in the jaw bone, and an implant intended for this purpose

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EP (1) EP1551326A1 (https=)
JP (1) JP2005533597A (https=)
AU (2) AU2003242161A1 (https=)
BR (1) BR0312906A (https=)
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JP2008307186A (ja) * 2007-06-13 2008-12-25 Univ Kurume 顎骨の再生に使用する顎骨用移植材料及びその製造方法
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DE102008053892A1 (de) 2008-10-30 2010-05-06 Fachhochschule Gelsenkirchen Medizinisches Implantat mit biofunktionalisierter Oberfläche
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AU2003242161A1 (en) 2004-02-16
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US8167618B2 (en) 2012-05-01
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