US20050165489A1 - Frusto-conical spinal implant - Google Patents

Frusto-conical spinal implant Download PDF

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Publication number
US20050165489A1
US20050165489A1 US11085745 US8574505A US2005165489A1 US 20050165489 A1 US20050165489 A1 US 20050165489A1 US 11085745 US11085745 US 11085745 US 8574505 A US8574505 A US 8574505A US 2005165489 A1 US2005165489 A1 US 2005165489A1
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Prior art keywords
implant
bone
upper
implants
present invention
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Abandoned
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US11085745
Inventor
Gary Michelson
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Warsaw Orthopedic Inc
Michelson Gary K
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SDGI Holdings Inc
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Abstract

The present invention is directed to a variety of interbody spinal fusion implants having at least a partially frusto-conical configuration. The spinal fusion implants of the present invention may be relatively solid or hollow and may have surface roughenings to promote bone ingrowth and stability. The spinal fusion implants of the present invention may have wells extending into the material of the implant from the surface for the purpose of holding fusion promoting materials and to provide for areas of bone ingrowth fixation. A variety of surface irregularities may be employed to increase implant stability and implant surface area, and/or for the purpose of advancing the spinal fusion implant into the fusion site.

Description

    RELATED APPLICATIONS
  • This application is a continuation application Ser. No. 08/484,928, filed Jun. 7, 1995, which is incorporated herein by reference.
  • The disclosures of U.S. Pat. Nos. 5,015,247; 5,484,437; and 6,080,155 are incorporated by reference herein.
  • BACKGROUND OF THE INVENTION
  • 1. Field of the Invention
  • The present invention relates generally to interbody spinal fusion implants, and in particular to spinal fusion implants configured to restore and maintain two adjacent vertebrae of the spine in anatomical lordosis.
  • 2. Description of the Related Art
  • Interbody spinal fusion refers to the method of achieving bony bridging between adjacent vertebrae through the disc space, the space between adjacent vertebrae normally occupied by a spinal disc. Numerous implants to facilitate such a fusion have been described by Cloward, Brantigan, and others, and are known to those skilled in the art. Generally, cylindrical implants offer the advantage of conforming to an easily prepared recipient bore spanning the disc space and penetrating into each of the adjacent vertebrae. Such a bore may be created by use of a drill. It is an anatomical fact that both the cervical spine and the lumbar spine are normally lordotic, that is convex forward. Such alignment is important to the proper functioning of the spine. Commonly, those conditions which require treatment by spinal fusion are associated with a loss of lordosis.
  • Therefore, there exists a need for spinal fusion implants that permit for the restoration of anatomical lordosis.
  • SUMMARY OF THE INVENTION
  • The present invention is directed to a variety of interbody spinal fusion implants having at least a partially frusto-conical configuration to achieve a desired anatomical lordosis of the spine. In the preferred embodiment, the spinal fusion implants of the present invention have an outer locus in which at least some of the points of the implant comprise a partially or fully frusto-conical shape substantially along those portions of the implant in contact with the adjacent vertebrae of the spine and have an insertion end and a trailing end. The spinal fusion implants of the present invention may be further modified so that while the upper and lower surfaces are portions of a frusto-cone, at least one side portion may be truncated to form a planar surface that is parallel to the central longitudinal axis of the implant to form straight walls. These implants may have a more tapered aspect at the insertion end of the implant to facilitate insertion. The spinal fusion implants of the present invention may be relatively solid and/or porous and/or hollow, and may have surface roughenings to promote bone ingrowth and stability.
  • The spinal fusion implants of the present invention may have wells extending into the material of the implant from the surface for the purpose of holding fusion promoting materials and to provide for areas of bone ingrowth fixation. These wells, or holes, may pass either into or through the implant and may or may not intersect. The spinal fusion implants of the present invention may have at least one chamber which may be in communication through at least one opening to the surface of the implant. Said chamber may have at least one access opening for loading the chamber with fusion promoting substances. The access opening may be capable of being closed with a cap or similar means. Still further, a variety of surface irregularities may be employed to increase implant stability and implant surface area, and/or for the purpose of allowing the spinal fusion implant to be inserted easily but to resist motion in the oppostion direction. The exterior of the spinal fusion implant of the present invention may have wholly or in part, a rough finish, knurling, forward facing ratchetings or other surface irregularities sufficient to achieve the purpose described.
  • The spinal fusion implants of the present invention offer significant advantages over the prior art implants:
  • 1. Because the spinal fusion implants of the present invention are at least partially frusto-conical in shape, those that taper from the leading edge to the trailing edge are easy to introduce and easy to fully insert into the spinal segment to be fused.
  • 2. The shape of the implants of the present invention is consistent with the shape of the disc, which the implants at least in part replace, wherein the front of the disc is normally taller than the back of the disc, which allows for normal lordosis. The implants of the present invention are similarly taller anteriorly than they are posteriorly.
  • 3. The spinal fusion implants of the present invention conform to a geometric shape, which shape is readily producible at the site of fusion, to receive said spinal fusion implants.
  • The spinal fusion implants of the present invention can be made of any material appropriate for human implantation and having the mechanical properties sufficient to be utilized for the intended purpose of spinal fusion, including various metals such as cobalt chrome, stainless steel or titanium including its alloys, various plastics including those which are bio-absorbable, and various ceramics or combination sufficient for the intended purpose. Further, the spinal fusion implants of the present invention may be made of a solid material, a mesh-like material, a porous material and/or may comprise, wholly or in part, materials capable of directly participating in the spinal fusion process, or be loaded with, composed of, treated or coated with chemical substances such as bone, morphogenic proteins, hydroxyapatite in any of its forms, and osteogenic proteins, to make them bioactive for the purpose of stimulating spinal fusion. The implants of the present invention may be wholly or in part bioabsorbable.
  • OBJECTS OF THE PRESENT INVENTION
      • It is an object of the present invention to provide a spinal fusion implant that is easily inserted into the spine, having a tapered leading end;
      • It is another object of the present invention to provide a spinal fusion implant that tapers in height from one end to the other consistent with the taper of a normal spinal disc;
      • It is yet another object of the present invention to provide a spinal fusion implant that is capable of maintaining anatomic alignment and lordosis of two adjacent vertebrae during the spinal fusion process;
      • It is still another object of the present invention to provide a spinal fusion implant that is self stabilizing within the spine;
      • It is yet another object of the present invention to provide a spinal fusion implant that is capable of providing stability between adjacent vertebrae when inserted;
      • It is still another object of the present invention to provide a spinal fusion implant that is capable of participating in the fusion process by containing, being composed of, or being treated with fusion promoting substances;
      • It is further another object of the present invention to provide a spinal fusion implant that is capable of spacing apart and supporting adjacent vertebrae during the spinal fusion process;
      • It is still further another object of the present invention to provide a spinal fusion implant that is consistent in use with the preservation of a uniform thickness of the subchondral vertebral bone;
      • It is another object of the present invention to provide a spinal fusion implant having a shape which conforms to an easily produced complementary bore at the fusion site; and
  • It is a further object of the present invention to provide a frusto-conical spinal fusion implant which may be placed side by side adjacent to a second identical implant across the same disc space, such that the combined width of the two implants is less than sum of the individual heights of each implant.
  • These and other objects of the present invention will become apparent from a review of the accompanying drawings and the detailed description of the drawings.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a side elevational view of an embodiment of the spinal fusion implant of the present invention having a frusto-conical body and a surface configuration comprising ratchetings for engaging bone, with wells and channels for bone ingrowth.
  • FIG. 1A is an enlarged fragmentary view along line 1A of FIG. 1 illustrating the surface configuration of the implant of FIG. 1.
  • FIG. 2 is a cross sectional view along line 2-2 of the implant of FIG. 1 illustrating the channels and wells of the implant of the present invention.
  • FIG. 3 is a cross sectional view along line 3-3 of the implant of FIG. 1 illustrating the channels and wells of the implant of the present invention.
  • FIG. 3A is a side elevational view of an alternative embodiment of the spinal fusion implant of the present invention having a frusto-conical body and a plurality of ratchetings forming a cylindrical external configuration.
  • FIG. 4 is a side elevational view of an alternative embodiment of the spinal fusion implant of the present invention having truncated sides forming a planar surface parallel to the longitudinal axis of the implant and ratchetings having a radius and height that are not constant.
  • FIG. 5 is a top plan view of the spinal fusion implant shown in FIG. 4.
  • FIG. 6 is a side elevational view of an alternative embodiment of the spinal fusion implant of the present invention having a body that is made out of a fibrous mesh-like material that is partially frusto-conical with one side that is truncated shown next to an identical second implant illustrated in hidden line.
  • FIG. 7 is sectional view along line 7-7 of the implants of FIG. 6.
  • FIG. 8 is an enlarged fragmentary view along line 8 of FIG. 6 illustrating the surface configuration of the implant of FIG. 6.
  • FIG. 9 is an enlarged fragmentary view along line 8 of FIG. 6 illustrating an alternative embodiment of the surface configuration of the implant of the present invention made of a cancellous material.
  • FIG. 10 is a cross sectional view along lines 10-10 of FIG. 9 illustrating the alternative embodiment of the surface configuration of the implant of the present invention made of a cancellous material.
  • FIG. 11 is a side elevational view in partial cut-away of an alternative embodiment of the spinal fusion implant of the present invention having a body that is frusto-conical and a surface configuration comprising a plurality of spaced apart posts.
  • FIG. 12 is an enlarged fragmentary sectional view along lines 12-12 of FIG. 11 illustrating the surface configuration of the implant of FIG. 11.
  • DETAILED DESCRIPTION OF THE DRAWINGS
  • Referring to FIG. 1, an embodiment of the spinal fusion implant of the present invention is shown and generally referred to by the numeral 220. The implant 220 has a frusto-conical body 222 and an outer locus that is generally frusto-conical substantially along the portion of the implant 220 that is in contact with the adjacent vertebrae of the spine. The implant 220 has a surface configuration of forward facing ratchetings 240 suitable for engaging the bone of the adjacent vertebrae. Each of the plurality of ratchetings 240 has a bone engaging edge 242 and ramped portion 244. The ratchetings 240 have a radius R4 measured from the central longitudinal axis L4 of the implant 220 that increases from the insertion end 224 to the trailing end 226. The height of the ratchetings 240 measured from the body 222 is constant throughout the length of implant 220.
  • The orientation of the ratchetings 240 makes the insertion of the implant 220 easier than its removal, as the ramped portions 244 act as an inclined plane on the way in, while the bone engaging edges 242 resist motion in the opposite directions. These forward facing ratchetings 240 tend to urge the implant 220 forward until the unremoved bone of the vertebrae blocks further motion resulting in a very stable spine and implant construct.
  • The implant 220 has a recessed slot 234 at its trailing end 226 for receiving and engaging insertion instrumentation for inserting the implant 220. The recessed slot 234 has a threaded opening 236 for threadably attaching the implant 220 to instrumentation used for inserting the implant 220.
  • In the preferred embodiment, the bone engaging edges 242 of the ratchetings 240 have a height at a highest point measured from the body 222 (root diameter) of the implant 220 in the range of 0.25-2.0 mm, with the preferred height being 0.4 mm for use in the cervical spine and 1.25 mm for use in the lumbar spine.
  • Referring to FIGS. 2 and 3, cross sectional views of implant 220 are shown. The implant 220 has channels 250 passing through the implant 220 and wells 260 formed in the surface of the implant 220. The wells 260 may or may not communicate with the channels 250. In the preferred embodiment of implant 220, the channels 250 have a diameter in the range of 0.1 mm to 6 mm, with 2-3 mm being the preferred diameter. The wells 260 have a diameter in the range of 0.1 mm to 6 mm, with 1-3 mm being the preferred diameter range. It is appreciated that although the channels 250 and wells 260 are shown having a generally rounded configuration, it is within the scope of the present invention that the channels 250 and wells 260 may have any size, shape, configuration, and distribution suitable for the intended purpose.
  • Referring to FIG. 1A, the implant 220 has an outer surface 238 that is porous to present an irregular surface to the bone to promote bone ingrowth. The outer surface 238 is also able to hold fusion promoting materials and provides for an increased surface area to engage the bone in the fusion process and to provide further stability. It is appreciated that the outer surface 238, and/or the entire implant 220, may comprise any other porous material or roughened surface sufficient to hold fusion promoting substances and/or allow for bone ingrowth and/or engage the bone during the fusion process. The implant 220 may be further coated with bioactive fusion promoting substances including, but not limited to, hydroxyapatite compounds, osteogenic proteins and bone morphogenic proteins. The implant 220 is shown as being solid, however it is appreciated that it can be made to be substantially hollow or hollow in part.
  • While the implant 220 is shown as being solid, it is appreciated that the implant 220 can be hollow at least in part to provide an internal chamber for holding bone or any fusion promoting material. Such an implant could have openings to allow bone external to the implant to grow into the internal chamber. Such structure is disclosed in detail in application Ser. No. 08/390,131, now U.S. Pat. No. 5,593,409, and application Ser. No. 08/074,781, now U.S. Pat. No. 5,484,437, both of which are incorporated herein by reference.
  • Referring to FIG. 3A, an alternative embodiment of the implant 220 is shown and generally referred to by the numeral 220′. The implant 220′ is similar in configuration to implant 220 except that the body 222′ of the implant is frusto-conical in configuration and the ratchetings 240′ have a radius R3 measured from the longitudinal central axis L4 that is constant in size from the insertion end 224′ to the trailing end 226′. The ratchetings 240′ each have a height measured from the body 222′ that is not constant throughout the length of the implant 220′ and decreases from the insertion end 224′ to the trailing end 226′. In this manner, the ratchetings 240′ form an external configuration of the implant 220′ that is substantially cylindrical in shape, while the body 222′ is frusto-conical. The insertion end of implant 220′ may have a tapered portion 223′ of lesser diameter to facilitate insertion of the implant 220′. The insertion end of the implant may also be larger than the trailing end where so desired.
  • Referring to FIGS. 4 and 5, an alternative embodiment of the implant 220 is shown and generally referred to by the numeral 220″. The implant 220″ is similar in configuration to implant 220 and has ratchetings 240″ having a radius R5 measured from the longitudinal central axis L5 that increases in size from the insertion end 224″ to the trailing end 226″. The ratchetings 240″ each have a height measured from the body 222″ that is not constant throughout the length of the implant 220″. In the preferred embodiment, the ratchet radius R5 and the ratchet height increase in size from the insertion end 224″ to the trailing end 226″.
  • As shown in FIG. 5, the implant 220″ has truncated sides 270 and 272 forming two planar surfaces which are diametrically opposite and are parallel to the longitudinal axis L5. In this manner, two implants 220″ may be placed side by side with one of the sides 270 or 272 of each implant touching, such that the area of contact with the bone of the adjacent vertebrae and the ratchetings 240″ is maximized. Alternatively, the implant 220″ may have one truncated side.
  • Referring to FIGS. 6-8, an alternative embodiment of the spinal fusion implant of the present invention is shown and generally referred to by the numeral 320 a. The implant 320 a is shown placed next to a second identical implant 320 b shown in hidden line. The implant 320 a has a body 322 that is made of a mesh-like material comprising strands, which may be made of metal, that are pressed together and molded into a partially frusto-conical configuration substantially along the portion of the implant 320 a in contact with the adjacent vertebrae of the spine. The implant 320 a has an insertion end 324 and a trailing end 326 and may be made wholly or in part of a solid material and/or a porous material, and/or a mesh-like material. The implant 320 a may have a surface comprising of a porous material, a mesh-like material, or have a surface that is roughened. It is appreciated that the implant 320 a may be solid or may be partially hollow and include at least one internal chamber. As shown in FIG. 8, the mesh-like material comprises strands that are formed and pressed together such that interstices 339, capable of retaining fusion promoting material and for allowing for bone ingrowth, are present between the strands in at least the outer surface 338 of implant 320 a.
  • Referring to FIGS. 9 and 10, alternatively the implant may be made of a cancellous material 350, similar in configuration to human cancellous bone, having interstices 352 such that the outer surface has a configuration as shown in FIGS. 9 and 10. As the implant may be made entirely or in part of the cancellous material 350, the interstices 352 may be present in the outer surface and/or within the entire implant to promote bone ingrowth and hold bone fusion promoting materials.
  • Referring again to FIG. 7, the implant 320 a is partially frusto-conical, similar in shape to implant 220 but having at least one truncated side 340 that forms a planar surface parallel to the central longitudinal axis of implant 320 a. The truncated side 340 allows for the placement of two implants 320 a and 320 b closer together when placed side by side between two adjacent vertebrae as set forth in U.S. patent application Ser. No. 08/390,131, now U.S. Pat. No. 5,593,409, incorporated herein by reference. Implant 320 a may be partially threaded or may otherwise resemble any of the other embodiments herein described or that are functionally equivalent.
  • Referring to FIG. 11, a side elevational view in partial cut-away of an alternative embodiment of the implant of the present invention is shown and generally referred to by the numeral 420. The implant 420 has a body 422 that is frusto-conical in shape substantially along the portion of the implant 420 that is in contact with the adjacent vertebrae of the spine and has an insertion end 424 and a trailing end 426. The implant 420 has an outer surface 438 that is capable of receiving and holding bone, or other materials capable of participating in the fusion process and/or capable of promoting bone ingrowth. In the preferred embodiment, the surface 438 comprises a plurality of posts 440 that are spaced apart to provide a plurality of interstices 442 which are partial wells with incomplete walls capable of holding and retaining milled bone material or any artificial bone ingrowth promoting material. The implant 420 may be prepared for implantation by grouting or otherwise coating the surface 438 with the appropriate fusion promoting substances.
  • Referring to FIG. 12, an enlarged view of the surface 438 of implant 420 is shown. In the preferred embodiment, the posts 440 have a head portion 444 of a larger diameter than the remainder of the posts 440, and each of the interstices 442 is the reverse configuration of the posts 444, having a bottom 446 that is wider than the entrance 448 to the interstices 442. Such a configuration of the posts 440 and interstices 442 aids in the retention of bone material in the surface 438 of the implant 420 and further assists in the locking of the implant 420 into the bone fusion mass created from the bone ingrowth. As the bone ingrowth at the bottom 446 of the interstices 442 is wider than the entrance 448, the bone ingrowth cannot exit from the entrance 448 and is locked within the interstice 442. The surface 438 of the implant 420 provides for an improvement in the available amount of surface area which may be still further increased by rough finishing, flocking or otherwise producing a non-smooth surface.
  • In the preferred embodiment, the posts 440 have a maximum diameter in the range of approximately 0.1-2 mm and a height of approximately 0.1-2 mm and are spaced apart a distance of approximately 0.1-2 mm such that the interstices 442 have a width in the range of approximately 0.1 to 2 mm. The post sizes, shapes, and distributions may be varied within the same implant.
  • While the present invention has been described in detail with regards to the preferred embodiments, it is appreciated that other variations of the present invention may be devised which do not depart from the inventive concept of the present invention. In particular, it is appreciated that the various teachings described in regards to the specific embodiments herein may be combined in a variety of ways such that the features are not limited to the specific embodiments described above.
  • Each of the features disclosed in the various embodiments and their functional equivalents may be combined in any combination sufficient to achieve the purposes of the present invention as described herein.

Claims (22)

  1. 1. An interbody spinal fusion implant for insertion across the surgically corrected height of a disc space between two adjacent vertebral bodies of a human spine, said implant comprising:
    a leading end for insertion first into the disc space, a trailing end opposite said leading end, and a length between said ends;
    opposed upper and lower arcuate portions adapted to contact the adjacent vertebral bodies when implanted in the spine, said opposed upper and lower arcuate portions being angled relative to one another so as to maintain an angulation of the adjacent vertebral bodies relative to one another, said opposed upper and lower arcuate portions of said implant including at least one opening in communication with one another for permitting for the growth of bone from vertebral body to vertebral body through said implant;
    bone engaging projections for engaging said implant to the adjacent vertebral bodies, said bone engaging projections extending from at least a portion of said opposed upper and lower portions; and
    said implant being made of a material that is wholly bioabsorbable.
  2. 2. The implant of claim 1, wherein said implant includes two opposed sides between said upper and lower portions, at least one of said sides being planar along at least a portion of the length.
  3. 3. The implant of claim 1, wherein said bone engaging projections include a plurality of ratchetings.
  4. 4. The implant of claim 3, wherein said ratchetings are configured to facilitate insertion of said implant into the disc space and resist expulsion of said implant in a direction opposite to the direction of insertion.
  5. 5. The implant of claim 1, wherein said bone engaging projections include knurling.
  6. 6. The implant of claim 1, wherein said implant has a hollow interior and an access opening for accessing said hollow interior.
  7. 7. The implant of claim 6, wherein said hollow interior is capable of containing fusion promoting material.
  8. 8. The implant of claim 6, further comprising a cap for closing said access opening.
  9. 9. The implant of claim 1, wherein said trailing end is adapted to engage instrumentation for the insertion of said implant.
  10. 10. The implant of claim 1, wherein said implant is configured to be placed in close proximity in a side by side alignment to a second implant, said first and second implants when placed together having a combined overall width that is less than the sum of the individual maximum diameters of each of said first and second implants.
  11. 11. The implant of claim 1, wherein said implant has a mid-longitudinal axis and at least one truncated side forming a planar surface parallel to the mid-longitudinal axis.
  12. 12. The implant of claim 1, in combination with a fusion promoting material.
  13. 13. The implant of claim 12, wherein said fusion promoting material includes at least one of bone, bone morphogenetic protein, hydroxyapatite, hydroxyapatite compounds, and osteogenic proteins.
  14. 14. The implant of claim 1, wherein said upper and lower portions each include a portion that is an arc of the same circle.
  15. 15. An interbody spinal fusion implant for insertion across the surgically corrected height of a disc space between two adjacent vertebral bodies of a human spine, said implant comprising:
    a leading end for insertion first into the disc space, a trailing end opposite said leading end, and a length between said ends;
    opposed upper and lower arcuate portions adapted to contact the adjacent vertebral bodies when implanted in the spine, said opposed upper and lower arcuate portions being angled relative to one another so as to maintain an angulation of the adjacent vertebral bodies relative to one another; and
    a plurality of channels extending from one of said upper and lower arcuate portions to the other of said upper and lower arcuate portions for permitting for the growth of bone from vertebral body to vertebral body through said implant, at least two of said channels being isolated from one another by a portion of said implant.
  16. 16. The implant of claim 15, wherein said implant includes two opposed sides between said upper and lower portions, at least one of said sides being planar along at least a portion of the length.
  17. 17. The implant of claim 15, wherein said upper and lower portions include bone engaging projections for engaging said implant to the adjacent vertebral bodies.
  18. 18. The implant of claim 17, wherein said bone engaging projections include a plurality of ratchetings.
  19. 19. The implant of claim 17, wherein said bone engaging projections include knurling.
  20. 20. The implant of claim 15, wherein said implant is configured to be placed in close proximity in a side by side alignment to a second implant, said first and second implants when placed together having a combined overall width that is less than the sum of the individual maximum diameters of each of said first and second implants.
  21. 21. The implant of claim 15, in combination with a fusion promoting material.
  22. 22. The implant of claim 21, wherein said fusion promoting material includes at least one of bone, bone morphogenetic protein, hydroxyapatite, hydroxyapatite compounds, and osteogenic proteins.
US11085745 1988-06-13 2005-03-19 Frusto-conical spinal implant Abandoned US20050165489A1 (en)

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US08484928 US6923810B1 (en) 1988-06-13 1995-06-07 Frusto-conical interbody spinal fusion implants
US11085745 US20050165489A1 (en) 1995-06-07 2005-03-19 Frusto-conical spinal implant

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US11085745 US20050165489A1 (en) 1995-06-07 2005-03-19 Frusto-conical spinal implant

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US08484928 Continuation US6923810B1 (en) 1988-06-13 1995-06-07 Frusto-conical interbody spinal fusion implants

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US08484928 Active US6923810B1 (en) 1988-06-13 1995-06-07 Frusto-conical interbody spinal fusion implants
US11085706 Expired - Fee Related US7691148B2 (en) 1988-06-13 2005-03-19 Frusto-conical spinal implant
US11085745 Abandoned US20050165489A1 (en) 1988-06-13 2005-03-19 Frusto-conical spinal implant
US12798364 Expired - Lifetime US7942933B2 (en) 1988-06-13 2010-04-03 Frusto-conical spinal implant
US13109791 Expired - Fee Related US8409292B2 (en) 1988-06-13 2011-05-17 Spinal fusion implant

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US08484928 Active US6923810B1 (en) 1988-06-13 1995-06-07 Frusto-conical interbody spinal fusion implants
US11085706 Expired - Fee Related US7691148B2 (en) 1988-06-13 2005-03-19 Frusto-conical spinal implant

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US12798364 Expired - Lifetime US7942933B2 (en) 1988-06-13 2010-04-03 Frusto-conical spinal implant
US13109791 Expired - Fee Related US8409292B2 (en) 1988-06-13 2011-05-17 Spinal fusion implant

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US (5) US6923810B1 (en)
EP (2) EP0836457B1 (en)
JP (2) JP4011616B2 (en)
CN (1) CN1149059C (en)
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