US20050038460A1 - Occlusive coil manufacture and delivery - Google Patents

Occlusive coil manufacture and delivery Download PDF

Info

Publication number
US20050038460A1
US20050038460A1 US10939660 US93966004A US2005038460A1 US 20050038460 A1 US20050038460 A1 US 20050038460A1 US 10939660 US10939660 US 10939660 US 93966004 A US93966004 A US 93966004A US 2005038460 A1 US2005038460 A1 US 2005038460A1
Authority
US
Grant status
Application
Patent type
Prior art keywords
coil
method
defect
device
shape memory
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10939660
Inventor
Swaminathan Jayaraman
Original Assignee
Swaminathan Jayaraman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214Coils or wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214Coils or wires
    • A61B17/12145Coils or wires having a pre-set deployed three-dimensional shape
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/1214Coils or wires
    • A61B17/1215Coils or wires comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12172Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12177Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00592Elastic or resilient implements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00606Implements H-shaped in cross-section, i.e. with occluders on both sides of the opening
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00623Introducing or retrieving devices therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831Material properties
    • A61B2017/00867Material properties shape memory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205Introduction devices
    • A61B2017/12054Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12095Threaded connection

Abstract

The present invention includes a coiled wire formed of a shape memory material for implantation into an anatomical defect. After implantation of one or more of the coiled wires according to the present invention, the defect is occluded and thereby corrected or treated. Prior to implantation, the coiled wire is generally elongated and thereafter it reverts to a predetermined shape that is suitable for occluding the defect. At least one clip having at least two prongs may be provided on the wire for attachment to body tissue. Preferably the wire is made of nickel-titanium. In an alternative embodiment, the coil includes a plurality of layers. At least one of these layers is formed of a shape memory material.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • This application is a Divisional of U.S. patent application Ser. No. 09/739,830, filed Dec. 20, 2000, which claims priority of Provisional Application Ser. No. 60/171,593 filed Dec. 23, 1999 under 35 U.S.C. § 119(e).
  • FIELD OF THE INVENTION
  • The present invention relates to a device for filling an anatomical defect. In particular, the device of the present invention is formed of a member which includes a shape memory alloy.
  • BACKGROUND OF THE INVENTION
  • In various body tissues, defects may occur either congenitally or as a result of operative procedures. Such defects may include abnormal openings, for example, in the cardiovascular system including the heart. Procedures have been developed to introduce devices for closing such abnormal openings. Embolization, the therapeutic introduction of a substance into a vessel in order to occlude it, is a treatment used in cases such as patent ductus arteriosus (PDA), major aortopulmonary collateral arteries, pulmonary arteriovenous malformations, venovenous collaterals following venous re-routing operations, occlusion of Blalock-Taussig (BT) shunts, and occlusion of coronary arteriovenous (AV) fistulas.
  • For example, a PDA is a congenital defect, and thus is present at and exists from the time of birth. In this abnormality, a persistent embryonic vessel connects the pulmonary artery and the aorta, and intervention is usually required to effect closure. A cardiologist may employ a variety of coils for this purpose, the coils being delivered through a catheter and subsequently placed in the opening to permit proper physiological functioning. In some cases, several coils may be used to occlude the opening.
  • Another abnormality is an atrial septal defect (ASD), which is a defect in the wall of the heart, known as the septum, that separates the right atrium and left atrium. Such as hole in the septum often requires an invasive procedure for closure of the defect. Similarly, intervention is often required in the case of a ventricular septal defect (VSD), a hole in the wall separating the right and left ventricles.
  • The use of coils in the intracranial region of the brain for embolizing aneurysms or fistulas is also generally accepted.
  • Each one of the aforementioned exemplary closure applications requires a specially designed coil which may be introduced into the particular anatomical location. For example, the geometry of the lumen in instances of PDA often requires complicated positioning of the coil for proper functioning. Additionally, an initially indeterminate number of coils may be required to close a given defect, as the decision to deliver multiple coils to a particular defect site is governed by the success of any preceding delivery.
  • A variety of devices and materials have been used to occlude such abnormal channels. For example, U.S. Pat. No. 4,994,069 to Ritchart et al., the contents of which are herein incorporated by reference, discloses vaso-occulusion wire formed of platinum, tungsten, or gold thread. The wire is advanced through a catheter, and upon release from the catheter into a vessel, it assumes a randomly coiled shape. Although the wire of this development is described as having memory, the type of memory property of these materials is not that of a shape memory material having transition temperatures for various material states.
  • Additionally, U.S. Pat. No. 5,192,301 to Kamiyama et al., discloses a closing plug for closing a defect in a somatic wall. The plug is formed of a polymer such as polynorbornene, styrene-butadiene coploymer, polyurethane, or transpolyisoprene. Although these polymers are described as “shape memory” polymers, they are unlike metallic materials displaying shape memory behavior. Many polymers display a glass-transition temperature (Tg) which represents a sharp change that occurs from a hard and glassy state to a rubbery, soft, or flexible thermoplastic state. If deformed by a load at a temperature below its Tg, a so-called “shape memory” polymer may retain the deformation until heated above the Tg, at which point the deformation and the original shape are recoverable. This characteristic of some polymers is often described as “elastic memory”.
  • A variety of other spring coil configurations have been used, although stainless steel and platinum have emerged as the most common materials. U.S. Pat. No. 5,649,949 to Wallace et al., discloses vasoocclusive coils formed from platinum, gold, rhodium, rhenium, palladium, tungsten, and alloys thereof. Wires formed of composites of these metals and polymers are also disclosed. These materials are inappropriate for the present development because they do not have the shape memory properties of materials such as nitinol. Among the several superior properties of nitinol when compared to stainless steel, the most important include strong physiological compatibility, a substantially lower modulus of elasticity, and a much greater tolerance to strain before the onset of permanent, plastic deformation. In fact, nitinol may have an elasticity an order of magnitude greater than that of stainless steel.
  • U.S. Pat. No. 5,645,558 to Horton discloses an occlusive device formed of superelastic alloys, such as nitinol. The device is spherical in shape. U.S. Pat. No. 5,382,259 to Phelps et al. further discloses the use of nitinol shape memory wire to form coils. Fibers are also woven to the coils. These coils do not have the shape of the present development.
  • Various other coil configurations have been proposed. For example, as disclosed in U.S. Pat. No. 6,117,157 to Tekulve, a helically shaped embolization coil includes bent ends. In addition, U.S. Pat. No. 6,126,672 to Berryman et al. discloses a coil for occluding an intracranial blood vessel. The coil has an anchor in the shape of an “M” or “W” for contacting the blood vessel. The free legs of the anchor are blunted and reinforced to prevent perforation of the vessel wall.
  • The success and extent of coil usage may be partially gauged through analysis of the PDA coil registry, the largest database covering use of coils to occlude ducts, which surveys more than 500 cases. Among those included in the database, patients ranged in age from 15 days to 71 years, with a median of 4.2 years. The median PDA size was 2 mm, with a range of less than one to about 7 mm. The immediate complete occlusion rate was 75%, and partial occlusion or any degree of shunt occurred in about 25% of the cases. Failure to implant occurred in 5% of the cases. Coil embolization occurred in 9.7% of the cases involving the pulmonary artery, and in 2.4% of the cases involving the systemic artery.
  • Analysis of data from the coil registry has revealed that an acute occlusion rate and failure was significantly related to coil size. Shorter studies with longer follow up show a cumulative occlusion rate of 98%. While the registry does not address the overall success rate of closure of PDA-associated ducts greater than 4 mm in size because of the statistical limitations of the data set, the immediate results of procedures directed to large ducts are encouraging. Initial complete occlusion occurred in 84.2%, or 16 of 19 cases. In addition, small residual shunts which closed spontaneously or required a second procedure occurred in 10.5%, or 2 of 19 cases, and failure of the procedure necessitating further surgical intervention to effectuate closure occurred in only 5.5%, or 1 of 19 cases. Coil embolization occurred in 16.5%, or 3 of 19 cases, and left pulmonary artery stenosis occurred in 11%, or 2 of 19 cases. It should be noted, however, that left artery stenosis and failure of the procedure were associated with attempts on neonates and infants. Thus, the effectiveness of coils appears to be unquestionably demonstrated.
  • The device of the present development may be used in a variety of applications, including but not limited to pediatric cardiology procedures directed at occluding either congenital defects or defects arising during the growth process. As previously discussed, such defects include PDA, ASD, VSD, major aortopulmonary collateral arteries, pulmonary arteriovenous malformations, venovenous collaterals following venous re-routing operations, occlusion of Blalock-Taussig (BT) shunts, and occlusion of coronary arteriovenous (AV) fistulas. The device is also useful in treating patent foramen ovale, a persistent opening in the wall of the heart that failed to close after birth.
  • The device of the present development is also suitable for use in other non-cardiac, vascular procedures. For example, the device may be used in aneurysmal or fistulous conditions. The shape of the device is chosen based on the shape of the defect. In the case of an aneurysm, the device is placed within the aneurysm as a filler, and may be clipped to ends of the aneurysm to anchor it in place. The device occupies the space of the malformation, with the shape of the device chosen to conform with the shape of the defect. Helical, conical, or spiral device shapes are contemplated, among others.
  • In addition, the device of the present development may be used specifically for neurovascular applications. The device may be delivered to malformations in the brain, such as aneurysms, tumors, or fistulae.
  • Moreover, the device of the present development may be use in esophageal, tracheal, or other non-vascular applications. In such instances, the device may be used to fill voids, or extra-anatomic space.
  • SUMMARY OF THE INVENTION
  • The present invention relates to a device for occluding an anatomical defect in a mammal. The device includes a member formed of a shape memory alloy, the member having a free bottom end and a free top end, a first predetermined unexpanded shape, and a second predetermined expanded shape. The unexpanded shape is substantially linear and the expanded shape is substantially conical, with the expanded shape having a plurality of loops coaxially disposed about a longitudinal axis and progressively decreasing in diameter from one end of the device to the other. At least one of the ends of the member includes a clip having at least two prongs for contacting areas adjacent the anatomical defect.
  • In one embodiment, the loops form a substantially conical coil having a constant pitch. Alternatively, the loops can form a substantially conical coil having a variable pitch.
  • The device may be formed of a shape memory nickel-titanium alloy, such as nitinol, and the member may be substantially arcuate in cross-section. At least one of the prongs may additionally include a sharp portion for attaching to an area adjacent the defect. Preferably, the diameter of the plurality of loops is smaller than about 1.5 cm.
  • The shape memory alloy may display a one-way shape memory effect, or a two-way shape memory effect.
  • In yet another embodiment, the shape memory alloy displays a superelastic effect at body temperature. Preferably, the shape memory alloy has an austenite finish temperature below body temperature, thereby permitting the device to have superelastic properties at body temperature.
  • The member may include a plurality of layers. At least one layer may be formed of a passive memory material, and in another embodiment at least two layers may be formed of active memory materials.
  • In another embodiment, at least one of the layers is a wire formed of a shape memory material, and at least one of the layers is a braid formed of a shape memory material. Preferably, the plurality of layers includes at least two layers braided together or one layer surrounded by a braid.
  • The device may include at least one crooked section, a substantially conical section, and a substantially cylindrical section disposed between the crooked section and the conical section.
  • The present invention also relates to a method of occluding an anatomical defect in the vascular tree of a mammal. The method include the steps of: delivering a member formed of a shape memory alloy in a first, substantially straight configuration to an anatomical defect in the body, the member having a temperature below a first transition temperature; and allowing the member to warm above a second transition temperature and form a second, predetermined, coiled configuration having an end with a clip having at least two prongs, wherein the prongs contact areas adjacent the anatomical defect for occlusion of same.
  • In a preferred embodiment, the second, predetermined, coiled configuration is substantially conical. In another preferred embodiment, the second, predetermined, coiled configuration may include a substantially conical section ending at a free end, at least one crooked section, and a substantially cylindrical section disposed therebetween. Preferably, the second, predetermined, coiled configuration is generally at least one of circular, rectangular, offset coiled, concentric coiled, and combinations thereof.
  • The present invention further relates to a method of manufacturing a superelastic device for placement inside an anatomical defect, including: providing an inner mandril of a preselected shape for supporting a coil of a wire formed of a shape memory material; winding the wire about the mandril to create a coil conforming to the mandril shape; providing an outer mold to completely surround the coil and mandril and thereby constrain movement of the wire with respect to the mandril; heating the outer mold for a predetermined period of time while the outer mold surrounds the coil and mandril; and allowing the coil to cool.
  • In addition, the present invention relates to a device for occluding an anatomical defect. The device includes a member formed of a shape memory alloy, the member having a free bottom end and a free top end, a first predetermined unexpanded shape, and a second predetermined expanded shape. The unexpanded shape is sufficiently compact for delivery of the device to the defect. The expanded shape is sufficiently enlarged to occlude the defect by providing a plurality of inner loops and at least one outer loop coaxially disposed about a longitudinal axis, the inner loops progressively decreasing in diameter from a wide end of the device to a narrow end of the device. The at least one outer loop has a diameter greater than the diameter of the inner loops at the narrow end of the device. The device may include at least two prongs for contacting areas adjacent the defect.
  • The present invention also relates to a method of delivering a device for occluding an anatomical defect. The method includes the steps of: providing a coil having a proximal portion, a transition portion, and a distal portion, and further having an initial length; placing the coil in a movable sheath for delivery to the defect; delivering the movable sheath through the anatomical defect, the anatomical defect having a near side, an inner region, and a far side; withdrawing a portion of the movable sheath from the anatomical defect and allowing the distal portion of the coil to emerge from the sheath; allowing the distal portion of the coil to reach body temperature and expand to a spiral configuration at the far side of the anatomical defect; withdrawing a further portion of the movable sheath from the anatomical defect and allowing the further portion of the coil to emerge from the sheath; and allowing a further portion of the coil to reach body temperature and expand within the anatomical defect.
  • In a preferred embodiment, the further portion of the coil is the transition portion which expands within the inner region of the anatomical defect. The method may further include the steps of: withdrawing an additional portion of the movable sheath from the anatomical defect and allowing the proximal portion of the coil to emerge from the sheath; and allowing the proximal portion of the coil to reach body temperature and expand to a spiral configuration at the near side of the anatomical defect.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • Preferred features of the present invention are disclosed in the accompanying drawings, wherein similar reference characters denote similar elements throughout the several views, and wherein:
  • FIG. 1 is a perspective view of one embodiment of a conically coiled member according to the present invention;
  • FIG. 2 is a side view of the conically coiled member of FIG. 1;
  • FIG. 3 is another side view of the conically coiled member of FIG. 2 rotated clockwise 180°;
  • FIG. 4 is another side view of the conically coiled member of FIG. 2 rotated counterclockwise 90°;
  • FIG. 5 is another side view of the conically coiled member of FIG. 2 rotated clockwise 90°;
  • FIG. 6 is a top view of the conically coiled member of FIG. 2;
  • FIG. 7 is a bottom view of the conically coiled member of FIG. 2;
  • FIG. 8 is a perspective view of an alternate embodiment of a coiled member according to the present invention and having a configuration combining a conical portion, a cylindrical portion, and a generally linear portion;
  • FIG. 9 is a side view of the coiled member of FIG. 8;
  • FIG. 10 is another side view of the coiled member of FIG. 9 rotated counterclockwise 180°;
  • FIG. 11 is another side view of the coiled member of FIG. 9 rotated counterclockwise 90°;
  • FIG. 12 is another side view of the coiled member of FIG. 9 rotated clockwise 90°;
  • FIG. 13 is a bottom view of the coiled member of FIG. 9;
  • FIG. 14 is a top view of the coiled member of FIG. 9;
  • FIG. 15 is a collection of top views of various embodiments of coiled members according to the present invention, including (a)-(b) coils with loops that are not all coaxial about a central axis, (c) a coil with a lower, crooked anchor or clip section, (d)-(e) coils having lower anchors or clips with complex curvature, (f)-(k) coils having lower anchors or clips in fan or star-like configurations;
  • FIG. 16 is a perspective view of an alternate embodiment of a coiled member according to the present invention and having 1.5 loops;
  • FIG. 17 is a top view of another alternate embodiment of a coiled member according to the present invention;
  • FIG. 18 is a perspective view of the coiled member of FIG. 17;
  • FIG. 19 is a side view of another alternate embodiment of a coiled member according to the present invention;
  • FIG. 20 is another embodiment of a coiled member according to the present invention, rotated in various orientations;
  • FIG. 21 is another alternate embodiment of a coiled member according to the present invention, rotated in various orientations;
  • FIG. 22 is another embodiment of a coiled member according to the present invention, shown in (a) side view, (b) top view, (c) side view, and (d) perspective view;
  • FIG. 22A is another embodiment of a coiled member according to the present invention, shown in side view;
  • FIG. 23 is another embodiment of a coiled member according to the present invention, shown in (a) side view of the extended state, (b) side view of the final shape, and (c) perspective view of the final shape;
  • FIG. 24 is another embodiment according to the present invention, showing a sheath-based coil delivery system with partial side views of (a) the sheath and coil extended through an anatomical defect in tissue, (b) the sheath partially withdrawn and a portion of the coil exposed, and (c) the sheath completely withdrawn with the coil fully exposed;
  • FIG. 25(a) is a side view of a member formed of two layers; and
  • FIG. 25(b) is a cross-sectional view of a braid portion disposed around a central core.
  • DETAILED DESCRIPTION OF THE INVENTION
  • In the description which follows, any reference to either direction or orientation is intended primarily and solely for purposes of illustration and is not intended in any way as a limitation to the scope of the present invention. Also, the particular embodiments described herein, although being preferred, are not to be considered as limiting of the present invention.
  • The most preferred applications of the shape memory alloy members of the present invention are as vasoocclusive devices for filling or blocking anatomical defects, such as openings, in the vascular tree, e.g., holes in veins, arteries or the heart of a mammal. The coil portion of the device is placed or allowed to extend within the opening, where it is contacted by blood. Blood thrombosis upon contact with the coil thus fills in open areas to prevent further blood transport through the defect.
  • Referring to FIG. 1, there is shown a device or coil 10 that is formed in a conical spring configuration with a top end portion 12 and a bottom end portion 14. The coil 10 has a generally helical or spiral form. The top end 16 and bottom end 18 are joined by a series of loops 20. The loops 20 are coaxially disposed about a central longitudinal axis extending from the bottom end portion 14 to the top end portion 12. Coil 10 defines an inner area 13 and an outer area 15, the coil also having an inner surface 17 and outer surface 19 along each loop. In the embodiment illustrated in FIG. 1, the loops 20 decrease in diameter as they progress from the bottom end 18 to the top end 16. The coil in this embodiment is substantially conical, because it may not assume a perfectly conical configuration. Various side views of coil 10 are shown in FIGS. 2-5. For example, the coil 10 in FIG. 3 is rotated from the position shown in FIG. 2 clockwise 180° about the longitudinal axis extending from the bottom end portion 14 to the top end portion 12. FIG. 4 results from a counterclockwise rotation of 90°, while FIG. 5 results from a clockwise rotation of 90°. FIGS. 6 and 7 show the coil 10 from the top and bottom, respectively.
  • An alternative embodiment of the device 22 according to the present invention is shown in FIGS. 8-14. Device 22 includes an upper portion 24 having a top end 26 and a bottom portion 28 having a bottom end 30. Upper portion 24 has a substantially conical coiled section 32 followed by a substantially cylindrical section 34 and thereafter a generally linear section 36 that includes two crooked sections 38 and 40. The substantially conical and substantially cylindrical sections may not be precisely conical or cylindrical, respectively. As shown, the device 22 extends continuously from top end 26 to bottom end 30. Device 22 defines an inner area 33 and an outer area 35, the device also having an inner surface 37 and outer surface 39 along each loop. Various side views of device 22 are shown in FIGS. 9-13. For example, the device 22 in FIG. 10 is rotated from the position shown in FIG. 9 counterclockwise 180° about the longitudinal axis extending from the bottom portion 28 to the upper portion 24. FIG. 11 results from a counterclockwise rotation of 90°, while FIG. 12 results from a clockwise rotation of 90°. FIGS. 13 and 14 show the device 22 from the bottom and top, respectively.
  • In another alternate embodiment, not shown in the figures, the device 22 is substantially barrel shaped, or is provided with a substantially barrel shaped portion.
  • Various other configurations of coils according to the present invention are shown in FIG. 15. FIGS. 15(a)-(b) show coils 100 and 102, respectively, having loops that are not all coaxial about a central axis. FIG. 15(c) shows a coil 104 having a lower, crooked anchor section. FIGS. 15(d)-(e) show coils 106 and 108, respectively, having lower anchors with complex curvature. Also, FIGS. 15(f)-(k) show coils 110, 112, 114, 116, 118, and 120, respectively, having lower anchors or clips in fan or star-like configurations. Preferably, each clip has at least two prongs for contacting the tissue at the anatomical defect. The prongs may be curved prongs 109 and/or sharp prongs 111. Advantageously, the use of prong configurations permits multiple anchor points to tissue adjacent the anatomical defect, and thus also provides additional securing of the device to the defect region.
  • The pitch of a coil, defined as the center-to-center distance between adjacent loops 20, may be constant or variable along the central longitudinal axis. The free length of the coil, defined as the overall length of the coil measured along the central longitudinal axis extending from the bottom end 18 to the top end 16, is chosen based on the geometry of the physiological defect in question. Additionally, the coils may be right-handed or left-handed spirals. Furthermore, the decrease in diameter of the loops may be constant or variable.
  • In the preferred embodiment, the coil is not close-wound with adjacent loops 20 contacting each other. Instead, the loops 20 forming the ends 18 and 16 do not contact adjacent loops. Alternatively, the coil may be provided in close-wound form.
  • Another configuration of a coil according to the present invention is shown in FIG. 16. This coil 122 has only 1.5 loops. In a preferred embodiment, coil 122 has a maximum diameter of D1 of 10 mm, and the total length of material used to form the coil is 44 mm. The radius of the full loop is different from the radius of the half loop. FIGS. 17-18 show yet another configuration of a coil according to the present invention. In a preferred embodiment, coil 124 has a maximum diameter of D2 of 4.00 mm, and a maximum coiled length L1 of 4.77 mm. In addition, the total length of material used to form coil 124 is 56 mm. Notably, the coil has a conical section with the smallest loop of the conical section also followed by a loop of larger diameter.
  • In another alternate embodiment shown in FIG. 19, a coil 126 has a generally conical profile, however the first and last loops each have a greater overall diameter than any of the intermediate loops.
  • FIGS. 20 and 21 show two additional coils 128 and 130, respectively, according to the present development, each rotated in several orientations. Each coil includes an anchor portion that spirals away from the coil. An anchor portion 129 is clearly shown, for example, at the bottom of FIG. 20(a). However, either end of the coil may serve this function.
  • FIGS. 22(a)-(d) show another coil according to the present development. Coil 132 has a first end 134 and second end 136. Although coil 134 is generally conical in overall shape, several loops are formed toward first end 134 such that an inner set of loops 138 and an outer set of loops 140 are formed. The inner set of loops 138 at first end 134 have a smaller diameter than the inner set of loops 138 at second end 136.
  • In a variant of the coil shown in FIGS. 22(a)-(d), a coil 142 is shown in FIG. 22A with an inner set of loops 144 that form a cone from a first region 145 to a second region 146. An outer set of loops 148 also are provided, and extend from the narrow, first region 145. The inner set of loops 144 proximate first region 145 have a smaller diameter than the inner set of loops 144 at second region 146. In addition, in the embodiment as shown in FIG. 22A, the diameters of the outer set of loops 148 increase from the first region 145 toward the second region 146. When the coil is disposed in an anatomical defect region such as a hole, the outer set of loops may be disposed adjacent the ends of the hole and/or within the hole at a position along the hole length.
  • All embodiments of the coils may be adapted to include a clip on at least one of the coil ends. The clip enhances attachment of the coil to its surroundings. The clip may be a prong-like extension from the coil that has at least one generally straight section. Furthermore, the clip may be oriented transverse to the central longitudinal axis of the coil, or it may extend parallel to the axis. The choice of clip orientation may be partially determined by the type of anatomical defect to be filled. Alternatively, the clip may be in the form of a lower anchor with an arcuate configuration, or a complex structure such as a star-like configuration.
  • The closure device is a coil made of a shape memory alloy. Such a material may be deformed at a temperature below a transition temperature region that defines a region of phase change, and upon heating above the transition temperature region assumes an original shape. The coil is preferably made of an alloy having shape-memory properties, including, but not limited to, the following alloys: Ni—Ti, Cu—Al—Ni, Cu—Zn, Cu—Zn—Al, Cu—Zn—Si, Cu—Sn, Cu—Zn—Sn, Ag—Cd, Au—Cd, Fe—Pt, Fe—Mn—Si, In—Ti, Ni—Al, and Mn—Cu. The coil is most preferably made of a nickel-titanium alloy. Such nickel-titanium alloys have gained acceptance in many medical applications, including stents used to reinforce vascular lumens.
  • NiTi alloys are particularly suitable for coils because of their shape memory and superelastic properties. These alloys have two temperature-dependent phases, the martensite or lower temperature phase, and the austenite or higher temperature phase. When the alloy is in the martensitic phase, it may be deformed due to its soft, ductile, and even rubber-like behavior. In the austenitic phase, the alloy is much stronger and rigid, although still reasonably ductile, and has a significantly higher Young's Modulus and yield strength. While the material transforms from one phase to the other, the transformation temperature range is dependent on whether the material is being heated or cooled. The martensite to austenite transformation occurs during heating, beginning at an austenite start temperature, As, and ending at an austenite finish temperature, Af. Similarly, the austenite to martensite transformation occurs during cooling, beginning at a martensite start temperature, Ms, and ending at a martensite finish temperature, Mf. Notably, the transition temperatures differ depending on heating and cooling, behavior known as hysteresis.
  • Some alloys display a “one-way” shape memory effect; essentially, this is an ability of the material to have a stored, fixed configuration (sometimes referred to as a trained shape), that may be deformed to a different configuration at a temperature below the phase change region, and subsequently may be heated above the transition temperature region to reassume that original configuration. A select group of alloys also display a “two-way” shape memory effect, in which the material has a first, fixed configuration at low temperature, and a second, fixed configuration at temperatures above the phase change. Thus, in this case, the material may be trained to have two different shapes.
  • Superelasticity (sometimes referred to as pseudoelasticity) occurs over a temperature range generally beginning at Af, and ending when the NiTi is further heated to a martensite deformation temperature, Md, that marks the highest temperature at which a stress-induced martensite occurs. In some cases, superelasticity may be observed at temperatures extending below Af. The superelasticity of the material in this temperature range permits the material to be deformed without plastic deformation, and thus permanent deformation is avoided.
  • In order to fix the shapes that the NiTi is to assume, a proper heat treatment must be applied. Depending on the application and the particular shape-memory or superelastic effect to be used, shapes may be fixed at each of the desired temperatures above or below the transitions.
  • The various transition temperatures and other materials properties of Ni—Ti may be tailored to the application in question. Due to the solubility of alloying elements in the nickel-titanium system, it is possible to deviate from a 50-50 ratio of nickel to titanium, by having either more nickel or titanium, or by adding alloying elements in relatively small quantities. Typical dopants include chromium, iron, and copper, although other elements may be selectively added to affect the properties. In addition, mechanical treatments, such as cold working, and heat treatments, such as annealing, may significantly change the various properties of the material.
  • Although the Ni-50% Ti shape memory alloy is generally referred to as nitinol, an abbreviation for Nickel Titanium Naval Ordnance Laboratory that recognizes the place of discovery, the term as used herein extends to nickel-titanium alloys that deviate from this ratio and that also may contain dopants.
  • The present invention also relates to a method of manufacturing coils and delivery of those coils. A substantially straight piece of nitinol wire may be introduced into specific regions of the body, and thereafter assumes a pre-set geometry. The delivery may take place through a sheath that serves a similar purpose to that of a catheter, or the temporarily straightened coil may be delivered through specific catheters. The wire remains straight until it is exposed to the inside of the body. Upon reaching the end of the delivery system, and warming to a temperature between 30° C. and 40° C., the normal body temperature, the wire may assume a predetermined shape. In a preferred embodiment, the wire assumes a shape as shown in FIGS. 1, 8 or 15. The choice of shape depends on the length of the wire introduced, as well as the anatomy where it is introduced. Various shapes are contemplated, including circular forms, rectangular forms, offset coiled forms having loops that are not coaxially disposed about a longitudinal axis, and concentric coiled forms, although the shape is not limited to these embodiments. In a preferred embodiment, the shape is helical, conical, or spiral. The wire may assume any open ended shapes as a final configuration, with the exception of a straight line.
  • As noted, the shape of the coil depends on the opening that needs to be filled with the coil. For example, in order to close the congenital malformation associated with a PDA, coils having shapes shown in FIGS. 1, 8 and 15 are appropriate. In a preferred embodiment, the maximum coil diameter is less than 1.5 cm. In another preferred embodiment, the sizes of the coil may be chosen as follows:
    maximum coil diameter (mm) 4 5 6 7 8 9
    diameter of the last loop (mm) 3 3.5 4 5 6 6
    side profile width (mm) 3 4 4 4 4 4
  • For each coil, the last loop may be provided with a back clip which is not conical in shape, and this clip attaches the coil in the area of the malformation. Preferably, during delivery of the coil, as it exits the delivery catheter it warms and assumes its predetermined loop-like configuration. If a clip is included with the coil, preferably the clip is released last from the catheter.
  • The device may be delivered via a 5 F (5 French) catheter that may be placed via a 6 F sheath. In its substantially straight configuration, the device should snugly fit in the catheter for slidable delivery.
  • The introduction device may also include a small metallic tube that initially completely houses the straightened device. The tube may be temporarily attached to the proximal end of the catheter, and the device may subsequently be inserted into the catheter with the help of a guidewire. The guidewire preferably is substantially straight, has a diameter similar to that of the wire used to form the coil, and additionally has a generally stiff end and a soft end. Once the device has been completely placed in the catheter, the tube is discarded, and the guidewire is used to place the device at the distal tip of the catheter and effect delivery of the device to the desired anatomical location.
  • Generally, if the device must be retrieved due to improper positioning, the retrieval must occur prior to delivery of the final loop section of the coil. Otherwise, a more complex coil removal procedure may be necessary. In order to facilitate coil delivery, radiopaque markers may be provided on the device, and preferably are provided on a top side at proximal and/or distal ends. In an alternate embodiment, markers may be provided continuously or in spaced, regular intervals along the length of the device. The use of such markers allows device delivery to be precisely monitored. Thus, if a device is not delivered properly to the chosen anatomical location, the device may be withdrawn into the sheath for re-release or may be completely withdrawn from the body.
  • In order for coil retrieval to occur, the coil is gripped at one end using a jaw or other retention mechanism as typically used with biopsy-related devices. Alternatively, other coil delivery and retrieval procedures involving pressure may be used, i.e. air pressure and suction. Prior to completion of coil delivery, if for example improper coil alignment has resulted or an improper coil shape or size has been chosen, the retention mechanism may be used to withdraw the coil into the sheath.
  • Alternatively, as shown in FIGS. 23-24, a coil 150 initially may be provided in an extended state such that its overall coiled length is L2, and when delivered the coil assumes a final shape with an overall coiled length L3. The final shape of coil 150 includes a transition section 152 between two spiral sections 154. Although the transition section 152 is generally straight in FIG. 23, transition section 152 may alternatively include loops forming a conical portion. Preferably, spiral sections 154 are formed such that the loops are generally coplanar. While coil movement may be constrained by a retention mechanism that, for example, grasps an end of a proximal portion of the coil, delivery of a coil such as coil 150 may be achieved using a movable sheath 156 and associated catheter.
  • A catheter may be used to deliver a coil 150 to an anatomical region. As shown in FIG. 24(a), a central shaft 158 is inserted through a hole 160 or other anatomical defect to be filled in tissue 162, which is depicted in partial side view. Such a hole 160, for example, may exist in a patient's heart in the septum. Central shaft 158 serves as a guidewire for the delivery of the coil. Preferably, central shaft 158 is surrounded by an inner sheath 159 formed of a braided metal wire having a layer of Teflon® (tetrafluoroethylene) on its inner surface for contacting central shaft 158 and a layer of Pebax® (polyether-block co-polyamide) on its outer surface for contacting coil 150. With central shaft 158 in place, an outer movable sheath 156 is extended through hole 160 using central shaft 158 as a guide. Preferably, outer movable sheath 156 is formed from polyethylene terephthalate (PET) or nylon. Coil 150 is disposed between inner sheath 159 and outer movable sheath 156. Coil 159 is wound about inner sheath 159, and restrained from expanding in the radial direction by outer movable sheath 156.
  • When outer movable sheath 156 is partially withdrawn, as shown in FIG. 24(b), a first, distal portion of coil 150 is exposed, warming to body temperature and thus assuming a preformed configuration. A first spiral section 154 forms on the far side of hole 160. Outer movable sheath 156 then may be further withdrawn, as shown in FIG. 24(c), exposing a transition portion of coil 150 and finally a proximal portion of coil 150 to the body, and thereby permitting coil 150 to assume the complete preformed configuration with a second spiral section 154 formed on the other, near side of hole 160. Coil 150 thus is held in place by the pressure applied by spiral sections 154 against tissue 162. A clip (not shown) also may be provided on one or both of spiral sections 154. A final coil release mechanism, such as a spring-release mechanism, may be used to separate coil 150 from the retention mechanism, and central shaft 158, inner sheath 159, and outer movable sheath 156 may be completely withdrawn from the body. A free end of coil 150 may be held by a biopsy forcep during the coil insertion procedure, to aid in the positioning and initial withdrawal of the sheath so that a spiral section 154 can be formed. In addition, the free ends of the coil may be capped or otherwise formed in the shape of beads. Such beads provide regions of increased thickness, and thus are detectable by x-ray equipment to aid in verification of coil positioning. The beads may also provide suitable structure for gripping by forceps. The sheath delivery method is particularly appropriate for the placement of coils having an overall length greater than twenty percent the length of the delivery catheter.
  • Several factors must be considered when choosing the size and shape of a coil to be used in a particular defect region. The desired helical diameter of the coil, a measure of the final diameter of the coil after expansion to its circular shape and implantation, must be considered in light of the geometry of the defect. In addition, the length of the coil and the number of coil loops must be considered. Furthermore, coils may be designed with tightly packed windings, windings having only a short distance between each loop, or loosely packed windings having greater separation between neighboring loops. The length of the coil places an additional constraint on the number of loops that may be provided. Coils may be packaged and provided to the medical community based on any of the aforementioned factors, or a combination thereof.
  • In a preferred embodiment, the coils are provided based on the substantially straightened length of the wire and/or the number of coil loops. Alternatively, the coils may be provided for selection based on coil length and/or helical diameter. In a simple case, if all loops had the same diameter, for example, the circumference of a representative loop could be determined by multiplying the helical diameter by π. The number of loops could thus be determined by a supplier or medical practitioner by dividing the substantially straightened length by the circumference of the representative loop. In designs having variable loop diameters, the circumferences of the individual loops must be known in order to determine the number of loops for a given length of wire.
  • In general, the coil size should be chosen to have a helical diameter approximately 20% to 30% larger than the narrowest size of the abnormality to be occluded. Otherwise, distal migration may occur if the coil is too small, and coils that are too large may be unable to fully assume their intended final geometry. Coils which assume the same size as the area to be occluded may still permit blood flow, and thus will fail to adequately fill the defect. The coil caliber is determined by catheter size used to cannulate the vessel.
  • In general, the helical diameter of the coil should be 2 to 3 times the size of the narrowest point of the duct to be occluded. This is especially appropriate for duct sizes less than about 2.5 mm. However, multiple coils may be required to achieve complete occlusion of some ducts. In particular, ducts greater than about 4 mm may require between 3 to 6 coils to effectuate complete occlusion. This is important, for example, in the treatments of PDAs having defect sizes as large as 7 mm.
  • The coil may be made thrombogenic by attaching or weaving fibers along the length of the coil. In a preferred embodiment, Dacron strands are used.
  • The wire used to form the coils preferably has an outer diameter of 0.018″, 0.025″, 0.035″, or 0.038″, and may be pre-loaded into a stainless steel or plastic tube for simple and direct insertion into the catheter or other delivery device. Several wires may be braided together in order to produce a wire with a desired outer diameter; for example, several wires each having outer diameters of approximately 0.010″ may be used to create a wire having an overall outer diameter close to 0.038″. Furthermore, a single wire may be encapsulated in a multi-strand braid.
  • The catheter chosen should be of soft material so that it may assume the shape of a tortuous vessel. Preferably, it should be free of any side holes, and the internal diameter should be chosen to closely mimic the internal diameter of the coil. Using a catheter of larger bore than the straightened length of the wire may cause the coil to curl within the passageway. The use of shape-memory wire allows the wire to have greater resiliency in bending, and thus permanent, plastic deformations may still be avoided even if difficulties are encountered during wire delivery.
  • The importance of duct characterization cannot be overemphasized. The safest ducts to occlude are those which funnel into small areas. All ducts, however, do not fit this profile. Some ducts, for example, have a very short area of narrowing, followed by a widened portion. Additionally, some ducts have relatively long lengths with a relatively narrow diameter, followed by lengths with wider diameter. Proper choice of coil and delivery technique allows these ducts to be occluded as well.
  • Vessels with a serpentine configuration may complicate the coil delivery procedure. A vessel that is too tortuous may be inaccessible if standard catheters are employed. However, smaller catheters such as Tracker catheters may permit the vessel to be more easily negotiated, such as in cases of coronary AV fistulas. The advantage of such Tracker catheters is their ability to be tracked to the distal end of the fistula. The catheter is passed through larger guiding catheters which may be used to cannulate the feeding vessel such as the right or left coronary artery at its origin. Such a Tracker catheter may accommodate 0.018″ “micro-coils”.
  • Alternatively, in order to accommodate large coils such as 0.038″ coils, 4 F catheters such as those made by Microvena may be employed. For defects requiring such large coils, delivery may be made either from the arterial or venous end. Damage to the artery may be minimized if the femoral artery route is approached.
  • In patients requiring multiple coils, delivery may occur sequentially by accessing the duct in an alternating sequence from the arterial or venous route, or by simultaneous delivery from each route. In the latter case, the duct may be accessed by two or three catheters usually from the venous end. At least two coils may be released simultaneously in the aortic ampulla, with the pulmonary ends of the coils released sequentially. A third coil may be subsequently released through a third catheter placed at the duct. The advantage of the simultaneous technique is the ability to occlude very large ducts with individual coil sizes that are less than two or three times the size of the duct. Both techniques may also be used in combination.
  • An example of multiple coil deployment is illustrative. In order to occlude a 5.7 mm duct, two 8 mm coils along with one 5 mm coil were deployed by the simultaneous technique as previously described. Subsequent to this deployment, three additional 5 mm coils were deployed using the sequential technique, in order to achieve complete occlusion. This combined use of deployment techniques was essential to the success of the procedure, since use of only the sequential approach in this case would have theoretically necessitated a coil approximately 12 to 16 mm in size. Such an extreme size may be particularly troublesome in young children, and may result in unacceptable blockage of the pulmonary artery or protrusion beyond the aortic ampulla. In addition, such a large coil might result in a high incidence of embolization of the first one or two coils.
  • In order to decrease the incidence of coil embolization, a controlled release coil is useful. Such a spring coil design, reminiscent of the Gianturco coil, may be provided with a central passageway through which a delivery mandril is passed. Interlocking screws between the spring coil and the delivery wire assist in securing the coil until it has been delivered to a proper position in the duct. The coil may then be released by unscrewing the locking device. The use of this controlled release technique has been attributed to a decrease from 9% to only 1.8% in the incidence of coil embolization.
  • In another preferred embodiment of the coil design, a plurality of active memory and passive memory elements are used. Advantageously, such a combination permits a desired coil stiffness and length to be achieved, and further facilitates the use of coils with extended ends or clips. In a preferred method of fabricating the coil, a coil wire is wound on top of a core wire using conventional winding techniques to create a multilayered wire. Preferably, a high precision winding device is used, such as the piezo-based winding system developed by Vandais Technologies Corporation of St. Paul, Minn. The coil wire is preferably rectangular or arcuate in cross-section, but other cross-sections such as a hexagonal shape or other polygonal shape may be used. The coil wire is also preferably substantially uniform in cross-section. However, a gradually tapered wire may also be used. Preferably, the dimensions of the layered coils are chosen such that comparatively thick sections formed from passive materials are avoided, due to expansion difficulties that may arise when the coils are warmed to their preset configuration. Subsequent to winding the coil wire/core wire combination, the multilayered wire is wound about a mandrel having a desired shape, preferably a shape permitting a final coil configured as shown in FIGS. 1, 8 or 15. The coil may also be formed with or without clips for anchoring the device at or near the site of the anatomical defect. The entire assembly is next transported to a furnace, wherein the multilayered wire is heat treated to set the desired shape. The temperature and duration of any heat treatment is a function of the materials used to form the multilayered wire. Following heat treatment, the assembly is removed from the furnace and allowed to cool to room temperature. The coil may then be removed from the mandrel. Depending on the materials used for the core wire and coil wire, a coil having a combination of active and passive memory elements may be produced.
  • In some alternate embodiments, the heat treating of the wire formed from a shape memory material is performed prior to winding a non-shape memory wire about it.
  • For example, nitinol coil wire may be used to confer active memory to the device, due to its shape memory and/or superelastic properties. Stainless steel, carbon fiber, or Kevlar® (poly-paraphenylene terephthalamide) fiber core wire may be used to confer passive memory because they are materials that may be given heat-set memory, but do not possess shape memory properties. Other appropriate passive-memory materials include relatively soft metals such as platinum and gold, relatively hard metals such as titanium or Elgiloy® (Cobalt-Chromium-Nickel alloy), or non-metals such as polytetrafluoroethylene (PTFE) or Dacron® (synthetic or natural fiber). The multilayered wire advantageously allows the device to possess several distinct materials properties; a wire layer of carbon fiber may allow an extremely flexible device shape, while a wire layer of nitinol may provide necessary rigidity. This combination enhances the ability of the device to retain its shape regardless of the type of defect or forces encountered during deployment and usage. Furthermore, the carbon fiber or other passive material facilitates the navigation of the device through tortuous anatomical regions.
  • If carbon fiber is used as the core wire, then the coil wire cannot be wound directly on the core. In such a case, a suitable mandril is first used to wind the coil wire, which is next subjected to a heat treatment in a furnace. After removal from the furnace and cooling, the mandril is removed and the carbon fiber is placed on the inner surface of the coil wire.
  • Alternatively, the madril may be removed after winding the coil wire, so that the core wire may be placed on the inner surface of the coil wire. The multilayered wire may then again be placed on the mandril, and subjected to a heat treatment to set the desired shape.
  • In an alternate embodiment, the coil wire is bordered by a core wire on the inner surface of the device, and an additional overlayer wire on the outer surface of the device. In yet another embodiment, the coil wire is provided as a twisted pair with the second wire of the pair being formed of either an active memory material or a passive memory material.
  • In yet another alternate embodiment of a coil and method of fabricating a coil having a combination of active memory and passive memory elements, a core wire is wound on top of a coil wire. The coil wire may serve as either the active or passive memory element. Likewise, the core wire may serve as either the active or passive memory element.
  • In addition, the core and coil wires may be disposed about each other in various configurations. The core wire, for example, may be disposed longitudinally about the coil wire (i.e., oriented in mirror-image fashion). For example, as shown in FIG. 25(a), a member 200 may be formed of layers 202, 204. Alternatively, the core wire may be wrapped about the coil wire in spiral fashion. If several core wires or several coil wires are to be used in combination, the wires may be disposed about each other using one or both of the longitudinal planking or radial wrapping orientations.
  • In a preferred embodiment, a capping process may also be undertaken to allow the ends of the core and the wire to be welded and capped in order to avoid any fraying.
  • In another preferred embodiment, a braid may also be wound on top of a central core. The braid may be wound to a desired pitch, with successive turns oriented extremely close together or at varying distances apart. For example, as shown in FIG. 25(b), braid portions 210 may be disposed around a central core 212. When braids are wound in spaced fashion, the mandril is left exposed at various intervals. After the madril is removed, a suitable intermediate material may be used in its place.
  • Various central core materials are contemplated, including plastic, metal, or even an encapsulated liquid or gel. In a preferred embodiment, an active memory/active memory combination is used, thus necessitating central cores and braids made of shape memory materials. In a most preferred embodiment, the central core and braid are both made of nitinol.
  • In an alternate embodiment, one of the central core and braid is an active memory element and the other is a passive memory element.
  • After the multilayered wire is wound on the core using a winding machine, the wound material may be released from the tension of the machine. If nitinol is used, the superelastic properties of the nitinol produce a tendency of the wound form to immediately lose its wound configuration. In order to retain the shape, an external mechanical or physical force may be applied, such as a plastic sleeve to constrain the material. If a plastic sleeve is used, it may be removed prior to heat treatment.
  • A multi-part mold may also be used. Due to the superelastic properties of nitinol wire, it may be necessary to further constrain the wire on the mandril during the manufacturing process. Thus, an inner mandril may be used for winding the wire to a desired shape. After winding, an outer mold may be used to completely surround the wire on the mandril to constrain its movement with respect to the mandril. The mandril and mold create a multi-part mold that may be transferred to a furnace for the heat treatment process. In a preferred heat treatment, the wire must be heated to a temperature of approximately 450-600° C. Depending on the material used to form the multi-part mold, the mold may need to be heated to a suitably higher temperature in order for the wire encased within the mold to reach its proper heat set temperature. Only a short heat treatment at the set temperature may be required, such as thirty minutes. After cooling, the device must be removed from the multi-part mold and carefully inspected for any surface or other defects.
  • In a preferred embodiment, the coil device is provided with at least one clip, located at the end of a loop. The clip allows the device to be anchored in the desired anatomical region of the body.
  • Due to the superelastic and shape memory properties of nitinol, various devices are contemplated. The superelastic properties allow the coils to have excellent flexibility, while the shape memory properties allow the coils to be delivered through conventional catheters that otherwise could not easily accommodate the diverse defect shapes.
  • While various descriptions of the present invention are described above, it should be understood that the various features may be used singly or in any combination thereof. Therefore, this invention is not to be limited to only the specifically preferred embodiments depicted herein.
  • Further, it should be understood that variations and modifications within the spirit and scope of the invention may occur to those skilled in the art to which the invention pertains. Accordingly, all expedient modifications readily attainable by one versed in the art from the disclosure set forth herein that are within the scope and spirit of the present invention are to be included as further embodiments of the present invention. The scope of the present invention is accordingly defined as set forth in the appended claims.

Claims (23)

  1. 1. A method of occluding an anatomical defect in the vascular tree of a mammal, comprising:
    delivering a member formed of a shape memory alloy in a first, substantially straight configuration to an anatomical defect in the body, the member having a temperature below a first transition temperature; and
    allowing the member to warm above a second transition temperature and form a second, predetermined, coiled configuration having an end with a clip having a non-overlapping planer fan-like configuration with at least two prongs for contacting areas adjacent the anatomical defect, wherein the prongs contact areas adjacent the anatomical defect for occlusion of same.
  2. 2. The method of claim 1, further comprising selecting the member formed of the shape memory alloy, wherein the coiled condition has a coil diameter at least two times a diameter of the anatomical defect.
  3. 3. The method of claim 1, wherein the second, predetermined, coiled configuration is substantially conical.
  4. 4. The method of claim 3, wherein the conical coil configuration has a substantially constant pitch.
  5. 5. The method of claim 3, wherein the conical coil configuration has a substantially variable pitch.
  6. 6. The method of claim 1, wherein the second, predetermined, coiled configuration comprises a substantially conical section ending at a free end, at least one crooked section, and a substantially cylindrical section disposed therebetween.
  7. 7. The method of claim 1, wherein the second, predetermined, coiled configuration is generally at least one of circular, rectangular, offset coiled, concentric coiled, and combinations thereof.
  8. 8. The method of claim 1, wherein at least one of the prongs has a sharp portion for attaching to an area adjacent the defect.
  9. 9. The method of claim 1, wherein the shape memory alloy displays a one-way shape memory effect.
  10. 10. The method of claim 1, wherein the shape memory alloy displays a two-way shape memory effect.
  11. 11. The method of claim 1, wherein the shape memory alloy has an austenite finish temperature below body temperature, thereby permitting the device to have superelastic properties at body temperature.
  12. 12. The method of claim 1, wherein the shape memory alloy displays a superelastic effect at body temperature.
  13. 13. The method of claim 1, wherein the shape memory alloy member includes a plurality of layers.
  14. 15. The method of claim 13, wherein the plurality of layers includes at least one layer formed of a passive memory material.
  15. 16. The method of claim 13, wherein the plurality of layers includes at least two layers formed of active memory materials.
  16. 17. The method of claim 16, wherein at least one of the layers is a wire formed of a shape memory material, and at least one of the layers is a braid formed of a shape memory material.
  17. 18. The method of claim 13, wherein the plurality of layers includes at least two layers braided together or one layer surrounded by a braid.
  18. 19. A method of delivering a device for occluding an anatomical defect, the method comprising:
    providing a coil having a proximal portion, a transition portion, and a distal portion, and further having an initial length;
    placing the coil in a movable sheath for delivery to the defect;
    delivering the movable sheath through the anatomical defect, the anatomical defect having a near side, an inner region, and a far side;
    withdrawing a portion of the movable sheath from the anatomical defect and allowing the distal portion of the coil to emerge from the sheath;
    allowing the distal portion of the coil to reach body temperature and expand to a spiral configuration at the far side of the anatomical defect;
    withdrawing a further portion of the movable sheath from the anatomical defect and allowing the further portion of the coil to emerge from the sheath; and
    allowing a further portion of the coil to reach body temperature and expand within the anatomical defect.
  19. 20. The method of claim 19, wherein the further portion of the coil is the transition portion which expands within the inner region of the anatomical defect.
  20. 21. The method of claim 20, further comprising:
    withdrawing an additional portion of the movable sheath from the anatomical defect and allowing the proximal portion of the coil to emerge from the sheath; and
    allowing the proximal portion of the coil to reach body temperature and expand to a spiral configuration at the near side of the anatomical defect.
  21. 22. A device for occluding an anatomical defect, comprising
    a member formed of a shape memory alloy, the member having a free bottom end and a free top end, a first predetermined unexpanded shape, and a second predetermined expanded shape, wherein the unexpanded shape is sufficiently compact for delivery of the device to the defect and the expanded shape is sufficiently enlarged to occlude the defect by providing a plurality of inner loops and at least one outer loop coaxially disposed about a longitudinal axis, the inner loops progressively decreasing in diameter from a wide end of the device to a narrow end of the device, the at least one outer loop having a diameter greater than the diameter of the inner loops at the narrow end of the device.
  22. 23. The device of claim 22, wherein the device includes a clip having a non-overlapping planer fan-like configuration.
  23. 24. The device of claim 23, wherein the non-overlapping planer fan-like configuration with at least two prongs for contacting areas adjacent the anatomical defect.
US10939660 1999-12-23 2004-09-13 Occlusive coil manufacture and delivery Abandoned US20050038460A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US17159399 true 1999-12-23 1999-12-23
US09739830 US6790218B2 (en) 1999-12-23 2000-12-20 Occlusive coil manufacture and delivery
US10939660 US20050038460A1 (en) 1999-12-23 2004-09-13 Occlusive coil manufacture and delivery

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10939660 US20050038460A1 (en) 1999-12-23 2004-09-13 Occlusive coil manufacture and delivery
US11084946 US20050187564A1 (en) 1999-12-23 2005-03-21 Occlusive coil manufacturing and delivery

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09739830 Division US6790218B2 (en) 1999-12-23 2000-12-20 Occlusive coil manufacture and delivery

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11084946 Continuation-In-Part US20050187564A1 (en) 1999-12-23 2005-03-21 Occlusive coil manufacturing and delivery

Publications (1)

Publication Number Publication Date
US20050038460A1 true true US20050038460A1 (en) 2005-02-17

Family

ID=22624367

Family Applications (2)

Application Number Title Priority Date Filing Date
US09739830 Expired - Fee Related US6790218B2 (en) 1999-12-23 2000-12-20 Occlusive coil manufacture and delivery
US10939660 Abandoned US20050038460A1 (en) 1999-12-23 2004-09-13 Occlusive coil manufacture and delivery

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US09739830 Expired - Fee Related US6790218B2 (en) 1999-12-23 2000-12-20 Occlusive coil manufacture and delivery

Country Status (7)

Country Link
US (2) US6790218B2 (en)
EP (1) EP1239780B1 (en)
JP (1) JP2003517869A (en)
CA (1) CA2394581C (en)
DE (1) DE60040165D1 (en)
DK (1) DK1239780T3 (en)
WO (1) WO2001045571A1 (en)

Cited By (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020133193A1 (en) * 2000-01-05 2002-09-19 Ginn Richard S. Integrated vascular device with puncture site closure component and sealant and methods of use
US20030078598A1 (en) * 2000-01-05 2003-04-24 Integrated Vascular Systems, Inc. Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US20030195561A1 (en) * 2000-12-07 2003-10-16 Carley Michael T. Closure device and methods for making and using them
US20040153122A1 (en) * 2003-01-30 2004-08-05 Integrated Vascular Systems, Inc. Clip applier and methods of use
US20050055039A1 (en) * 2003-07-28 2005-03-10 Polymorfix, Inc. Devices and methods for pyloric anchoring
US20050187564A1 (en) * 1999-12-23 2005-08-25 Swaminathan Jayaraman Occlusive coil manufacturing and delivery
US20070010853A1 (en) * 2000-10-06 2007-01-11 Integrated Vascular Systems, Inc. Apparatus and methods for positioning a vascular sheath
US20070010854A1 (en) * 2001-06-07 2007-01-11 Christy Cummins Surgical Staple
US20070083230A1 (en) * 2005-10-07 2007-04-12 Alex Javois Left atrial appendage occlusion device
US20070178160A1 (en) * 2003-07-28 2007-08-02 Baronova, Inc. Gastro-intestinal device and method for treating addiction
US20070239199A1 (en) * 2006-03-31 2007-10-11 Swaminathan Jayaraman Inferior vena cava filter
US20070250132A1 (en) * 2003-07-28 2007-10-25 Baronova, Inc. Devices and methods for gastrointestinal stimulation
US20080004640A1 (en) * 2006-06-28 2008-01-03 Abbott Laboratories Vessel closure device
US20080272173A1 (en) * 2000-09-08 2008-11-06 Abbott Vascular Inc. Surgical stapler
US20080312666A1 (en) * 2003-01-30 2008-12-18 Abbott Laboratories Clip applier and methods of use
US20080319475A1 (en) * 2007-06-25 2008-12-25 Abbott Laboratories Methods, Devices, and Apparatus for Managing Access Through Tissue
DE102007032339A1 (en) * 2007-07-11 2009-01-15 Acandis Gmbh & Co. Kg Surgical implant for the closure of an endo-vascular aneurism has two truncated cones joined at apex
US20090182357A1 (en) * 2007-09-07 2009-07-16 Baronova, Inc. Device for intermittently obstructing a gastric opening and method of use
US20090187200A1 (en) * 2003-07-28 2009-07-23 Daniel Rogers Burnett Gastric retaining devices and methods
WO2009099437A1 (en) * 2008-02-05 2009-08-13 Boston Scientific Limited Apparatus and method for closing an opening in a blood vessel using memory metal and collagen
US20100114159A1 (en) * 2008-10-30 2010-05-06 Abbott Vascular Inc. Closure device
US20100160958A1 (en) * 2008-12-22 2010-06-24 Abbott Laboratories Closure Device
US20100179571A1 (en) * 2009-01-09 2010-07-15 Abbott Vascular Inc. Closure devices, systems, and methods
US20100241120A1 (en) * 2004-10-04 2010-09-23 Saint Louis University Intramedullary nail device and method for repairing long bone
US20110060355A1 (en) * 2002-12-31 2011-03-10 Integrated Vacular Systems, Inc. Methods for manufacturing a clip and clip
US20110071565A1 (en) * 2000-12-07 2011-03-24 Integrated Vascular Systems, Inc. Apparatus and methods for providing tactile feedback while delivering a closure device
US20110144663A1 (en) * 2002-06-04 2011-06-16 Abbott Vascular Inc. Blood Vessel Closure Clip and Delivery Device
US20110144668A1 (en) * 2000-12-07 2011-06-16 Integrated Vascular Systems, Inc. Closure device
US20110144664A1 (en) * 2003-01-30 2011-06-16 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8007512B2 (en) 2002-02-21 2011-08-30 Integrated Vascular Systems, Inc. Plunger apparatus and methods for delivering a closure device
US20110230897A1 (en) * 2003-01-30 2011-09-22 Integrated Vascular Systems, Inc. Clip applier and methods of use
WO2011084536A3 (en) * 2009-12-16 2011-11-03 Endoshape, Inc. Multi-fiber shape memory device
US20120158034A1 (en) * 2010-12-16 2012-06-21 Wilson Thomas S Expandable Implant and Implant System
US8303624B2 (en) 2010-03-15 2012-11-06 Abbott Cardiovascular Systems, Inc. Bioabsorbable plug
US8313497B2 (en) 2005-07-01 2012-11-20 Abbott Laboratories Clip applier and methods of use
US20130073054A1 (en) * 2009-11-24 2013-03-21 Georgia Tech Research Corporation Tissue support structure
US8590760B2 (en) 2004-05-25 2013-11-26 Abbott Vascular Inc. Surgical stapler
US8603116B2 (en) 2010-08-04 2013-12-10 Abbott Cardiovascular Systems, Inc. Closure device with long tines
US8657885B2 (en) 2003-07-28 2014-02-25 Baronova, Inc. Pyloric valve obstructing devices and methods
US8672953B2 (en) 2007-12-17 2014-03-18 Abbott Laboratories Tissue closure system and methods of use
US8690910B2 (en) 2000-12-07 2014-04-08 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8758399B2 (en) 2010-08-02 2014-06-24 Abbott Cardiovascular Systems, Inc. Expandable bioabsorbable plug apparatus and method
US8758398B2 (en) 2006-09-08 2014-06-24 Integrated Vascular Systems, Inc. Apparatus and method for delivering a closure element
US8758400B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Closure system and methods of use
US8808310B2 (en) 2006-04-20 2014-08-19 Integrated Vascular Systems, Inc. Resettable clip applier and reset tools
US8820602B2 (en) 2007-12-18 2014-09-02 Abbott Laboratories Modular clip applier
US8821534B2 (en) 2010-12-06 2014-09-02 Integrated Vascular Systems, Inc. Clip applier having improved hemostasis and methods of use
US8828051B2 (en) 2010-07-02 2014-09-09 Pfm Medical Ag Left atrial appendage occlusion device
US8858594B2 (en) 2008-12-22 2014-10-14 Abbott Laboratories Curved closure device
US8893947B2 (en) 2007-12-17 2014-11-25 Abbott Laboratories Clip applier and methods of use
US8905937B2 (en) 2009-02-26 2014-12-09 Integrated Vascular Systems, Inc. Methods and apparatus for locating a surface of a body lumen
US8920442B2 (en) 2005-08-24 2014-12-30 Abbott Vascular Inc. Vascular opening edge eversion methods and apparatuses
US8926633B2 (en) 2005-06-24 2015-01-06 Abbott Laboratories Apparatus and method for delivering a closure element
US9089311B2 (en) 2009-01-09 2015-07-28 Abbott Vascular Inc. Vessel closure devices and methods
US9149276B2 (en) 2011-03-21 2015-10-06 Abbott Cardiovascular Systems, Inc. Clip and deployment apparatus for tissue closure
US9282965B2 (en) 2008-05-16 2016-03-15 Abbott Laboratories Apparatus and methods for engaging tissue
US9314230B2 (en) 2009-01-09 2016-04-19 Abbott Vascular Inc. Closure device with rapidly eroding anchor
US9332976B2 (en) 2011-11-30 2016-05-10 Abbott Cardiovascular Systems, Inc. Tissue closure device
US9364209B2 (en) 2012-12-21 2016-06-14 Abbott Cardiovascular Systems, Inc. Articulating suturing device
US9414820B2 (en) 2009-01-09 2016-08-16 Abbott Vascular Inc. Closure devices, systems, and methods
US9414824B2 (en) 2009-01-16 2016-08-16 Abbott Vascular Inc. Closure devices, systems, and methods
US9456811B2 (en) 2005-08-24 2016-10-04 Abbott Vascular Inc. Vascular closure methods and apparatuses
US9486191B2 (en) 2009-01-09 2016-11-08 Abbott Vascular, Inc. Closure devices
US9579091B2 (en) 2000-01-05 2017-02-28 Integrated Vascular Systems, Inc. Closure system and methods of use
US9585647B2 (en) 2009-08-26 2017-03-07 Abbott Laboratories Medical device for repairing a fistula
US9681876B2 (en) 2013-07-31 2017-06-20 EMBA Medical Limited Methods and devices for endovascular embolization
US9808252B2 (en) 2009-04-02 2017-11-07 Endoshape, Inc. Vascular occlusion devices
US9848906B1 (en) 2017-06-20 2017-12-26 Joe Michael Eskridge Stent retriever having an expandable fragment guard
WO2018035167A1 (en) * 2016-08-16 2018-02-22 Spartan Micro, Inc. Intravascular flow diversion devices
US9936955B2 (en) 2011-01-11 2018-04-10 Amsel Medical Corporation Apparatus and methods for fastening tissue layers together with multiple tissue fasteners
US10010328B2 (en) 2013-07-31 2018-07-03 NeuVT Limited Endovascular occlusion device with hemodynamically enhanced sealing and anchoring
US10028733B2 (en) 2015-05-28 2018-07-24 National University Of Ireland, Galway Fistula treatment device
US10070981B2 (en) 2013-03-15 2018-09-11 Baronova, Inc. Locking gastric obstruction device and method of use
US10076339B2 (en) 2011-01-11 2018-09-18 Amsel Medical Corporation Method and apparatus for clamping tissue layers and occluding tubular body lumens
US10111664B2 (en) 2014-06-23 2018-10-30 Integrated Vascular Systems, Inc. Closure system and methods of use

Families Citing this family (237)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6682608B2 (en) * 1990-12-18 2004-01-27 Advanced Cardiovascular Systems, Inc. Superelastic guiding member
US6482224B1 (en) 1996-08-22 2002-11-19 The Trustees Of Columbia University In The City Of New York Endovascular flexible stapling device
US8016881B2 (en) 2002-07-31 2011-09-13 Icon Interventional Systems, Inc. Sutures and surgical staples for anastamoses, wound closures, and surgical closures
US7967855B2 (en) 1998-07-27 2011-06-28 Icon Interventional Systems, Inc. Coated medical device
US20030040790A1 (en) 1998-04-15 2003-02-27 Furst Joseph G. Stent coating
US8070796B2 (en) 1998-07-27 2011-12-06 Icon Interventional Systems, Inc. Thrombosis inhibiting graft
US20020099438A1 (en) * 1998-04-15 2002-07-25 Furst Joseph G. Irradiated stent coating
US7018401B1 (en) 1999-02-01 2006-03-28 Board Of Regents, The University Of Texas System Woven intravascular devices and methods for making the same and apparatus for delivery of the same
EP1210014A1 (en) * 1999-09-07 2002-06-05 Microvena Corporation Retrievable septal defect closure device
US6231561B1 (en) * 1999-09-20 2001-05-15 Appriva Medical, Inc. Method and apparatus for closing a body lumen
ES2244402T3 (en) * 1999-09-29 2005-12-16 Zimmer Gmbh Tissue holder.
WO2001039695A3 (en) * 1999-12-01 2002-02-21 Advanced Cardiovascular System Nitinol alloy composition for vascular stents
US6790218B2 (en) * 1999-12-23 2004-09-14 Swaminathan Jayaraman Occlusive coil manufacture and delivery
US6855154B2 (en) 2000-08-11 2005-02-15 University Of Louisville Research Foundation, Inc. Endovascular aneurysm treatment device and method
US20080091264A1 (en) * 2002-11-26 2008-04-17 Ample Medical, Inc. Devices, systems, and methods for reshaping a heart valve annulus, including the use of magnetic tools
US7029486B2 (en) 2000-09-26 2006-04-18 Microvention, Inc. Microcoil vaso-occlusive device with multi-axis secondary configuration
US6605101B1 (en) 2000-09-26 2003-08-12 Microvention, Inc. Microcoil vaso-occlusive device with multi-axis secondary configuration
US7033374B2 (en) 2000-09-26 2006-04-25 Microvention, Inc. Microcoil vaso-occlusive device with multi-axis secondary configuration
US6602272B2 (en) 2000-11-02 2003-08-05 Advanced Cardiovascular Systems, Inc. Devices configured from heat shaped, strain hardened nickel-titanium
US7976648B1 (en) 2000-11-02 2011-07-12 Abbott Cardiovascular Systems Inc. Heat treatment for cold worked nitinol to impart a shape setting capability without eventually developing stress-induced martensite
US6626937B1 (en) 2000-11-14 2003-09-30 Advanced Cardiovascular Systems, Inc. Austenitic nitinol medical devices
US6855161B2 (en) * 2000-12-27 2005-02-15 Advanced Cardiovascular Systems, Inc. Radiopaque nitinol alloys for medical devices
US8992567B1 (en) 2001-04-24 2015-03-31 Cardiovascular Technologies Inc. Compressible, deformable, or deflectable tissue closure devices and method of manufacture
US20080114394A1 (en) 2001-04-24 2008-05-15 Houser Russell A Arteriotomy Closure Devices and Techniques
JP4255286B2 (en) * 2001-05-17 2009-04-15 ウィルソン−クック メディカル インコーポレイテッド Intragastric device for the treatment of obesity
US7338514B2 (en) * 2001-06-01 2008-03-04 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and tools, and related methods of use
WO2003022344A3 (en) * 2001-09-06 2003-07-31 Nmt Medical Inc Flexible delivery system
US20080015633A1 (en) * 2001-09-06 2008-01-17 Ryan Abbott Systems and Methods for Treating Septal Defects
US20090054912A1 (en) * 2001-09-06 2009-02-26 Heanue Taylor A Systems and Methods for Treating Septal Defects
US8579936B2 (en) 2005-07-05 2013-11-12 ProMed, Inc. Centering of delivery devices with respect to a septal defect
US20060052821A1 (en) 2001-09-06 2006-03-09 Ovalis, Inc. Systems and methods for treating septal defects
US20070112358A1 (en) * 2001-09-06 2007-05-17 Ryan Abbott Systems and Methods for Treating Septal Defects
US6776784B2 (en) 2001-09-06 2004-08-17 Core Medical, Inc. Clip apparatus for closing septal defects and methods of use
US6702835B2 (en) 2001-09-07 2004-03-09 Core Medical, Inc. Needle apparatus for closing septal defects and methods for using such apparatus
CN105286937A (en) * 2001-11-07 2016-02-03 微温森公司 Vascular obstruction device
US20040111147A1 (en) * 2002-12-03 2004-06-10 Rabkin Dmitry J. Temporary, repositionable or retrievable intraluminal devices
EP1467661A4 (en) 2001-12-19 2008-11-05 Nmt Medical Inc Septal occluder and associated methods
US7318833B2 (en) * 2001-12-19 2008-01-15 Nmt Medical, Inc. PFO closure device with flexible thrombogenic joint and improved dislodgement resistance
US20030120302A1 (en) * 2001-12-20 2003-06-26 Scimed Life Systems, Inc. Vaso-occlusive device with serpentine shape
EP1471835A4 (en) * 2002-01-14 2008-03-19 Nmt Medical Inc Patent foramen ovale (pfo) closure method and device
US8328877B2 (en) * 2002-03-19 2012-12-11 Boston Scientific Scimed, Inc. Stent retention element and related methods
US7335221B2 (en) * 2002-04-12 2008-02-26 Ethicon, Inc. Suture anchoring and tensioning device and method for using same
US6638297B1 (en) 2002-05-30 2003-10-28 Ethicon Endo-Surgery, Inc. Surgical staple
US20030225423A1 (en) * 2002-05-30 2003-12-04 Huitema Thomas W. Surgical clip
CA2486919C (en) 2002-06-03 2011-03-15 Nmt Medical, Inc. Device with biological tissue scaffold for percutaneous closure of an intracardiac defect and methods thereof
CA2488337A1 (en) 2002-06-05 2003-12-18 Nmt Medical, Inc. Patent foramen ovale (pfo) closure device with radial and circumferential support
US20040034386A1 (en) * 2002-08-19 2004-02-19 Michael Fulton Aneurysm stent
US20040044391A1 (en) 2002-08-29 2004-03-04 Stephen Porter Device for closure of a vascular defect and method of treating the same
US7766820B2 (en) 2002-10-25 2010-08-03 Nmt Medical, Inc. Expandable sheath tubing
EP1596723A2 (en) * 2003-02-04 2005-11-23 ev3 Sunnyvale, Inc. Patent foramen ovale closure system
US7658747B2 (en) * 2003-03-12 2010-02-09 Nmt Medical, Inc. Medical device for manipulation of a medical implant
US7473266B2 (en) * 2003-03-14 2009-01-06 Nmt Medical, Inc. Collet-based delivery system
US7186251B2 (en) 2003-03-27 2007-03-06 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
US6939348B2 (en) 2003-03-27 2005-09-06 Cierra, Inc. Energy based devices and methods for treatment of patent foramen ovale
WO2004087235A3 (en) 2003-03-27 2005-01-06 Cierra Inc Methods and apparatus for treatment of patent foramen ovale
US7972330B2 (en) 2003-03-27 2011-07-05 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
US7367975B2 (en) 2004-06-21 2008-05-06 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US8021362B2 (en) 2003-03-27 2011-09-20 Terumo Kabushiki Kaisha Methods and apparatus for closing a layered tissue defect
US7293562B2 (en) 2003-03-27 2007-11-13 Cierra, Inc. Energy based devices and methods for treatment of anatomic tissue defects
US7165552B2 (en) 2003-03-27 2007-01-23 Cierra, Inc. Methods and apparatus for treatment of patent foramen ovale
US7306683B2 (en) * 2003-04-18 2007-12-11 Versitech Limited Shape memory material and method of making the same
US7942892B2 (en) * 2003-05-01 2011-05-17 Abbott Cardiovascular Systems Inc. Radiopaque nitinol embolic protection frame
US8480706B2 (en) 2003-07-14 2013-07-09 W.L. Gore & Associates, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
ES2428967T3 (en) * 2003-07-14 2013-11-12 W.L. Gore & Associates, Inc. tubular closure device patent foramen ovale (PFO) retention system
US9861346B2 (en) 2003-07-14 2018-01-09 W. L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
US8043321B2 (en) * 2003-07-24 2011-10-25 Boston Scientific Scimed, Inc. Embolic coil
US20050055050A1 (en) * 2003-07-24 2005-03-10 Alfaro Arthur A. Intravascular occlusion device
CA2536368A1 (en) * 2003-08-19 2005-03-03 Nmt Medical, Inc. Expandable sheath tubing
US7371244B2 (en) 2003-08-25 2008-05-13 Ethicon, Inc. Deployment apparatus for suture anchoring device
JP2007504885A (en) * 2003-09-11 2007-03-08 エヌエムティー メディカル, インコーポレイティッド Device for suturing tissue, system and method
US7419498B2 (en) * 2003-10-21 2008-09-02 Nmt Medical, Inc. Quick release knot attachment system
EP2213244A1 (en) * 2003-10-24 2010-08-04 ev3 Endovascular, Inc. Patent foramen ovale closure system
US20050090856A1 (en) * 2003-10-27 2005-04-28 Scimed Life Systems, Inc. Vasco-occlusive devices with bioactive elements
US7645292B2 (en) * 2003-10-27 2010-01-12 Boston Scientific Scimed, Inc. Vaso-occlusive devices with in-situ stiffening elements
US7666203B2 (en) 2003-11-06 2010-02-23 Nmt Medical, Inc. Transseptal puncture apparatus
US8292910B2 (en) 2003-11-06 2012-10-23 Pressure Products Medical Supplies, Inc. Transseptal puncture apparatus
US7056286B2 (en) 2003-11-12 2006-06-06 Adrian Ravenscroft Medical device anchor and delivery system
US20050113868A1 (en) * 2003-11-20 2005-05-26 Devellian Carol A. Device, with electrospun fabric, for a percutaneous transluminal procedure, and methods thereof
US20050273119A1 (en) 2003-12-09 2005-12-08 Nmt Medical, Inc. Double spiral patent foramen ovale closure clamp
US20080109057A1 (en) * 2003-12-10 2008-05-08 Calabria Marie F Multiple point detacher system
US20070104752A1 (en) * 2003-12-10 2007-05-10 Lee Jeffrey A Aneurysm embolization material and device
US20060106447A1 (en) * 2004-01-26 2006-05-18 Nmt Medical, Inc. Adjustable stiffness medical system
JP2007519498A (en) * 2004-01-30 2007-07-19 エヌエムティー メディカル, インコーポレイティッド Device for closing cardiac openings, systems, and methods
US20050192626A1 (en) * 2004-01-30 2005-09-01 Nmt Medical, Inc. Devices, systems, and methods for closure of cardiac openings
US20050187568A1 (en) * 2004-02-20 2005-08-25 Klenk Alan R. Devices and methods for closing a patent foramen ovale with a coil-shaped closure device
US7871419B2 (en) * 2004-03-03 2011-01-18 Nmt Medical, Inc. Delivery/recovery system for septal occluder
US8313505B2 (en) * 2004-03-19 2012-11-20 Aga Medical Corporation Device for occluding vascular defects
US8398670B2 (en) 2004-03-19 2013-03-19 Aga Medical Corporation Multi-layer braided structures for occluding vascular defects and for occluding fluid flow through portions of the vasculature of the body
US8777974B2 (en) 2004-03-19 2014-07-15 Aga Medical Corporation Multi-layer braided structures for occluding vascular defects
US9039724B2 (en) * 2004-03-19 2015-05-26 Aga Medical Corporation Device for occluding vascular defects
US20050234509A1 (en) * 2004-03-30 2005-10-20 Mmt Medical, Inc. Center joints for PFO occluders
US20050267524A1 (en) * 2004-04-09 2005-12-01 Nmt Medical, Inc. Split ends closure device
US8361110B2 (en) * 2004-04-26 2013-01-29 W.L. Gore & Associates, Inc. Heart-shaped PFO closure device
US8308760B2 (en) * 2004-05-06 2012-11-13 W.L. Gore & Associates, Inc. Delivery systems and methods for PFO closure device with two anchors
US7842053B2 (en) * 2004-05-06 2010-11-30 Nmt Medical, Inc. Double coil occluder
US7704268B2 (en) * 2004-05-07 2010-04-27 Nmt Medical, Inc. Closure device with hinges
US7842069B2 (en) 2004-05-07 2010-11-30 Nmt Medical, Inc. Inflatable occluder
CA2563298A1 (en) 2004-05-07 2005-11-24 Nmt Medical, Inc. Catching mechanisms for tubular septal occluder
US20050267495A1 (en) * 2004-05-17 2005-12-01 Gateway Medical, Inc. Systems and methods for closing internal tissue defects
US7794472B2 (en) * 2004-08-11 2010-09-14 Boston Scientific Scimed, Inc. Single wire intravascular filter
USRE46662E1 (en) 2004-09-17 2018-01-09 DePuy Synthes Products, Inc. Vascular occlusion device with an embolic mesh ribbon
EP1793744B1 (en) 2004-09-22 2008-12-17 Dendron GmbH Medical implant
US8845676B2 (en) 2004-09-22 2014-09-30 Micro Therapeutics Micro-spiral implantation device
CA2581677C (en) * 2004-09-24 2014-07-29 Nmt Medical, Inc. Occluder device double securement system for delivery/recovery of such occluder device
US8425550B2 (en) * 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
US20060206139A1 (en) * 2005-01-19 2006-09-14 Tekulve Kurt J Vascular occlusion device
US7540995B2 (en) * 2005-03-03 2009-06-02 Icon Medical Corp. Process for forming an improved metal alloy stent
US9107899B2 (en) 2005-03-03 2015-08-18 Icon Medical Corporation Metal alloys for medical devices
US7488444B2 (en) * 2005-03-03 2009-02-10 Icon Medical Corp. Metal alloys for medical devices
US7452501B2 (en) * 2005-03-03 2008-11-18 Icon Medical Corp. Metal alloy for a stent
US20060200048A1 (en) * 2005-03-03 2006-09-07 Icon Medical Corp. Removable sheath for device protection
WO2006110197A3 (en) 2005-03-03 2007-04-26 Icon Medical Corp Polymer biodegradable medical device
DE102005010222B4 (en) * 2005-03-05 2007-08-16 Haindl, Hans, Dr.med. Dipl.-Ing. Retention and crushing system for blood clots
US20060241687A1 (en) * 2005-03-16 2006-10-26 Glaser Erik N Septal occluder with pivot arms and articulating joints
US20060217760A1 (en) * 2005-03-17 2006-09-28 Widomski David R Multi-strand septal occluder
US8277480B2 (en) 2005-03-18 2012-10-02 W.L. Gore & Associates, Inc. Catch member for PFO occluder
US8372113B2 (en) * 2005-03-24 2013-02-12 W.L. Gore & Associates, Inc. Curved arm intracardiac occluder
US20060271089A1 (en) 2005-04-11 2006-11-30 Cierra, Inc. Methods and apparatus to achieve a closure of a layered tissue defect
US20070014831A1 (en) * 2005-07-12 2007-01-18 Hsing-Wen Sung Biodegradable occlusive device with moisture memory
US20070060895A1 (en) 2005-08-24 2007-03-15 Sibbitt Wilmer L Jr Vascular closure methods and apparatuses
US7846179B2 (en) 2005-09-01 2010-12-07 Ovalis, Inc. Suture-based systems and methods for treating septal defects
WO2007030433B1 (en) 2005-09-06 2007-08-23 David J Callaghan Jr Removable intracardiac rf device
US9259267B2 (en) 2005-09-06 2016-02-16 W.L. Gore & Associates, Inc. Devices and methods for treating cardiac tissue
US9943296B2 (en) * 2005-09-20 2018-04-17 Rob K. Rao Surgical method and clamping apparatus for repair of a defect in a dural membrane or a vascular wall, and anastomic method and apparatus for a body lumen
US20070083219A1 (en) * 2005-10-12 2007-04-12 Buiser Marcia S Embolic coil introducer sheath locking mechanisms
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
WO2007047851A3 (en) 2005-10-19 2009-03-26 Pulsar Vascular Inc Methods and systems for endovascularly clipping and repairing lumen and tissue defects
US8545530B2 (en) 2005-10-19 2013-10-01 Pulsar Vascular, Inc. Implantable aneurysm closure systems and methods
US20070129755A1 (en) * 2005-12-05 2007-06-07 Ovalis, Inc. Clip-based systems and methods for treating septal defects
US20070142859A1 (en) * 2005-12-19 2007-06-21 Boston Scientific Scimed, Inc. Embolic coils
US8152839B2 (en) * 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
EP1962695A1 (en) 2005-12-22 2008-09-03 NMT Medical, Inc. Catch members for occluder devices
US20070225738A1 (en) * 2006-03-24 2007-09-27 Cook Incorporated Aneurysm coil and method of assembly
US8551135B2 (en) 2006-03-31 2013-10-08 W.L. Gore & Associates, Inc. Screw catch mechanism for PFO occluder and method of use
US8870913B2 (en) 2006-03-31 2014-10-28 W.L. Gore & Associates, Inc. Catch system with locking cap for patent foramen ovale (PFO) occluder
CA2647505C (en) * 2006-03-31 2014-07-29 Nmt Medical, Inc. Deformable flap catch mechanism for occluder device
US8777979B2 (en) 2006-04-17 2014-07-15 Covidien Lp System and method for mechanically positioning intravascular implants
CA2649702C (en) 2006-04-17 2014-12-09 Microtherapeutics, Inc. System and method for mechanically positioning intravascular implants
US20070299461A1 (en) * 2006-06-21 2007-12-27 Boston Scientific Scimed, Inc. Embolic coils and related components, systems, and methods
US20110224720A1 (en) * 2010-03-11 2011-09-15 Cvdevices, Llc Devices, systems, and methods for closing a hole in cardiac tissue
US20080082083A1 (en) * 2006-09-28 2008-04-03 Forde Sean T Perforated expandable implant recovery sheath
RU2454974C2 (en) 2006-10-22 2012-07-10 Айдев Текнолоджиз, Инк. Devices and methods for stent movement
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
US20080145658A1 (en) * 2006-12-15 2008-06-19 Boston Scientific Scimed, Inc. Freeze Thaw Methods For Making Polymer Particles
US9387062B2 (en) * 2007-01-31 2016-07-12 Stanley Batiste Intravenous deep vein thrombosis filter and method of filter placement
US8617205B2 (en) 2007-02-01 2013-12-31 Cook Medical Technologies Llc Closure device
WO2008094706A3 (en) 2007-02-01 2009-02-19 Cook Inc Closure device and method of closing a bodily opening
US20080208214A1 (en) * 2007-02-26 2008-08-28 Olympus Medical Systems Corp. Applicator and tissue fastening method through natural orifice
CN101677821B (en) * 2007-03-13 2014-05-14 泰科保健集团有限合伙公司 Implant and mandrel
EP2124762B1 (en) * 2007-03-13 2013-09-11 Covidien LP An implant including a coil and a stretch-resistant member
WO2008124603A1 (en) * 2007-04-05 2008-10-16 Nmt Medical, Inc. Septal closure device with centering mechanism
WO2008127328A1 (en) * 2007-04-12 2008-10-23 Swaminathan Jayaraman Inferior vena cava filter
WO2008131167A1 (en) 2007-04-18 2008-10-30 Nmt Medical, Inc. Flexible catheter system
FR2915087A1 (en) * 2007-04-20 2008-10-24 Corevalve Inc Implant treatment of a heart valve, particularly a mitral valve implant inculant material and equipment for setting up of this implant.
EP2157937B1 (en) 2007-06-04 2017-03-22 Sequent Medical, Inc. Devices for treatment of vascular defects
US7694427B2 (en) * 2007-07-12 2010-04-13 Long Fredrick D Pipe fitting wireform for measuring linear distance and method
DE102007038446A1 (en) * 2007-08-14 2009-02-19 pfm Produkte für die Medizin AG Embolisiereinrichtung
JP5580737B2 (en) 2007-08-17 2014-08-27 ミクラス エンドバスキュラー エルエルシー For vascular treatment twist primary wind coil and its formation method, the secondary wind coil
US8308752B2 (en) * 2007-08-27 2012-11-13 Cook Medical Technologies Llc Barrel occlusion device
US8025495B2 (en) * 2007-08-27 2011-09-27 Cook Medical Technologies Llc Apparatus and method for making a spider occlusion device
US20090062838A1 (en) * 2007-08-27 2009-03-05 Cook Incorporated Spider device with occlusive barrier
US8734483B2 (en) * 2007-08-27 2014-05-27 Cook Medical Technologies Llc Spider PFO closure device
US8858576B2 (en) * 2007-09-10 2014-10-14 Olympus Medical Systems Corp. Tissue fastening tool, stent, applicator for placing the same, and tissue fastening method through natural orifice
US20090112238A1 (en) * 2007-10-26 2009-04-30 Vance Products Inc., D/B/A Cook Urological Inc. Fistula brush device
EP2207485A1 (en) * 2007-11-07 2010-07-21 Ovalis, Inc. Systems devices and methods for achieving transverse orientation in the treatment of septal defects
US8961541B2 (en) 2007-12-03 2015-02-24 Cardio Vascular Technologies Inc. Vascular closure devices, systems, and methods of use
US8968382B2 (en) 2007-12-11 2015-03-03 Cornell University Method and apparatus for restricting flow through an opening in the side wall
US20090163926A1 (en) * 2007-12-14 2009-06-25 Angiodynamics, Inc. Universal capture assembly
US8747453B2 (en) * 2008-02-18 2014-06-10 Aga Medical Corporation Stent/stent graft for reinforcement of vascular abnormalities and associated method
US20090227976A1 (en) * 2008-03-05 2009-09-10 Calabria Marie F Multiple biocompatible polymeric strand aneurysm embolization system and method
US20130165967A1 (en) 2008-03-07 2013-06-27 W.L. Gore & Associates, Inc. Heart occlusion devices
CN106974691A (en) 2008-05-02 2017-07-25 斯昆特医疗公司 Filamentary devices for treatment of vascular defects
JP2011520570A (en) * 2008-05-20 2011-07-21 オバリス, インコーポレイテッド Systems and methods for delivering a wire-like and other devices and the device for the treatment of septal defect
US8162958B2 (en) * 2008-07-11 2012-04-24 Olympus Medical Systems Corp. Tissue fastening tool and applicator for indwelling the same within body, and tissue fastening method through natural orifice
US20100010520A1 (en) 2008-07-11 2010-01-14 Olympus Medical Systems Corp. Tissue fastener
US20100010514A1 (en) 2008-07-11 2010-01-14 Olympus Medical Systems Corp. Tissue fastening tool
EP2330985A4 (en) 2008-09-04 2015-11-18 Curaseal Inc Inflatable devices for enteric fistula treatment
CN103976770B (en) 2008-09-05 2017-04-12 帕尔萨脉管公司 System and method for supporting or physiological opening or cavity occlusion
EP2204148B1 (en) 2008-12-30 2012-03-28 Medartis AG Implant for treatment of obstructive sleep apnea
WO2010118312A3 (en) 2009-04-09 2011-04-28 Cardiovascular Technologies, Inc. Tissue closure devices, device and systems for delivery, kits and methods therefor
EP2434960A1 (en) * 2009-05-28 2012-04-04 Cook Medical Technologies LLC Tacking device and methods of deployment
EP3300673A3 (en) 2009-09-04 2018-10-03 Pulsar Vascular, Inc. Systems for enclosing an anatomical opening
US10092427B2 (en) 2009-11-04 2018-10-09 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
US9649211B2 (en) 2009-11-04 2017-05-16 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
CN102639181A (en) 2009-11-05 2012-08-15 斯昆特医疗公司 Multiple layer filamentary devices or treatment of vascular defects
US9814562B2 (en) 2009-11-09 2017-11-14 Covidien Lp Interference-relief type delivery detachment systems
KR101250443B1 (en) * 2010-02-08 2013-04-08 권오기 Embolus forming in-vivo indwelling-coil and the makigng methods for Embolus forming in-vivo indwelling coil
US8398916B2 (en) * 2010-03-04 2013-03-19 Icon Medical Corp. Method for forming a tubular medical device
WO2011140186A1 (en) 2010-05-05 2011-11-10 Cook Medical Technologies Llc Treatment fluid delivery method, and turbulator for promoting uptake of a treatment agent
WO2011162287A1 (en) * 2010-06-22 2011-12-29 オリンパスメディカルシステムズ株式会社 Tissue clamp production method and tissue clamp
EP2588042A4 (en) 2010-06-29 2015-03-18 Artventive Medical Group Inc Reducing flow through a tubular structure
US9247942B2 (en) 2010-06-29 2016-02-02 Artventive Medical Group, Inc. Reversible tubal contraceptive device
WO2012051489A3 (en) 2010-10-15 2012-05-31 Cook Medical Technologies Llc Occlusion device for blocking fluid flow through bodily passages
US9149277B2 (en) 2010-10-18 2015-10-06 Artventive Medical Group, Inc. Expandable device delivery
US10028745B2 (en) 2011-03-30 2018-07-24 Noha, Llc Advanced endovascular clip and method of using same
EP2693981A4 (en) 2011-04-01 2015-07-01 Univ Cornell Method and apparatus for restricting flow through an opening in the side wall of a body lumen, and/or for reinforcing a weakness in the side wall of a body lumen, while still maintaining substantially normal flow through the body lumen
JP2014523284A (en) 2011-06-03 2014-09-11 パルサー バスキュラー インコーポレイテッド Including shock absorbing aneurysm device, system and method for enclosing an anatomical opening
JP6122424B2 (en) 2011-06-16 2017-04-26 キュラシール インコーポレイテッド Devices and related methods for fistula treatment
US9131941B2 (en) 2011-06-17 2015-09-15 Curaseal Inc. Fistula treatment devices and methods
US9770232B2 (en) 2011-08-12 2017-09-26 W. L. Gore & Associates, Inc. Heart occlusion devices
US8945171B2 (en) 2011-09-29 2015-02-03 Covidien Lp Delivery system for implantable devices
US8795313B2 (en) 2011-09-29 2014-08-05 Covidien Lp Device detachment systems with indicators
EP2763602A1 (en) 2011-10-05 2014-08-13 Pulsar Vascular, Inc. Devices, systems and methods for enclosing an anatomical opening
US9579104B2 (en) 2011-11-30 2017-02-28 Covidien Lp Positioning and detaching implants
US9211390B2 (en) * 2011-11-30 2015-12-15 Cook Medical Technologies, LLC Multi-functional wire guide assembly and method of using same
US9011480B2 (en) * 2012-01-20 2015-04-21 Covidien Lp Aneurysm treatment coils
US9687245B2 (en) 2012-03-23 2017-06-27 Covidien Lp Occlusive devices and methods of use
US9259229B2 (en) 2012-05-10 2016-02-16 Pulsar Vascular, Inc. Systems and methods for enclosing an anatomical opening, including coil-tipped aneurysm devices
DE102012010687A1 (en) * 2012-05-30 2013-12-05 Admedes Schuessler Gmbh A method for manufacturing a body implant assembly of a guide wire and a body implant and medical instrument
EP2854700A4 (en) 2012-05-31 2016-02-10 Javelin Medical Ltd Systems, methods and devices for embolic protection
US20140163586A1 (en) * 2012-12-11 2014-06-12 Dolly Jeanne Holt Tissue repair devices and methods
WO2014102767A3 (en) * 2012-12-27 2014-08-14 Javelin Medical Ltd. Apparatus and method of monofilament implant delivery in a body vessel of a patient
JP6370312B2 (en) 2013-01-18 2018-08-08 ジャベリン メディカル リミテッド System for monofilament implants, and its delivery
US9095344B2 (en) 2013-02-05 2015-08-04 Artventive Medical Group, Inc. Methods and apparatuses for blood vessel occlusion
US8984733B2 (en) 2013-02-05 2015-03-24 Artventive Medical Group, Inc. Bodily lumen occlusion
WO2014164496A1 (en) * 2013-03-11 2014-10-09 Ferry Steven J Flat wound detachable embolization coil
US20140277095A1 (en) * 2013-03-12 2014-09-18 Marshall Kerr Vascular Occlusion Device Configured for Infants
WO2014145012A3 (en) 2013-03-15 2015-03-26 Covidien Lp Delivery and detachment mechanisms for vascular implants
CA2902438A1 (en) * 2013-03-15 2014-09-18 Fabian Hermann Urban Fuglister Tongue deformation implant
US9737306B2 (en) 2013-06-14 2017-08-22 Artventive Medical Group, Inc. Implantable luminal devices
US9636116B2 (en) 2013-06-14 2017-05-02 Artventive Medical Group, Inc. Implantable luminal devices
US9737308B2 (en) 2013-06-14 2017-08-22 Artventive Medical Group, Inc. Catheter-assisted tumor treatment
US9968432B2 (en) 2013-06-28 2018-05-15 Cook Medical Technologies Llc Occlusion device including bundle of occlusion wires having preformed shapes
US8870948B1 (en) * 2013-07-17 2014-10-28 Cephea Valve Technologies, Inc. System and method for cardiac valve repair and replacement
US9955976B2 (en) 2013-08-16 2018-05-01 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects
US9078658B2 (en) 2013-08-16 2015-07-14 Sequent Medical, Inc. Filamentary devices for treatment of vascular defects
US9592110B1 (en) * 2013-12-06 2017-03-14 Javelin Medical, Ltd. Systems and methods for implant delivery
WO2015131081A1 (en) 2014-02-27 2015-09-03 Incumedx, Inc. Embolic framing microcoils
US9629635B2 (en) 2014-04-14 2017-04-25 Sequent Medical, Inc. Devices for therapeutic vascular procedures
US9713475B2 (en) 2014-04-18 2017-07-25 Covidien Lp Embolic medical devices
US9808230B2 (en) 2014-06-06 2017-11-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
US20160158000A1 (en) 2014-12-09 2016-06-09 Juan F. Granada Replacement cardiac valves and methods of use and manufacture
CN108601597A (en) * 2016-02-26 2018-09-28 波士顿科学国际有限公司 Conical spiral coil valve bronchus
JP2017213182A (en) * 2016-05-31 2017-12-07 国立大学法人信州大学 Embolization coil
WO2017221252A1 (en) * 2016-06-21 2017-12-28 Endostream Medical Ltd. Medical device for treating vascular malformations
KR101816069B1 (en) * 2016-09-08 2018-01-08 한국과학기술연구원 Coil spring crimp using shape memory alloy and method for manufacturing of the same

Citations (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619246A (en) * 1984-05-23 1986-10-28 William Cook, Europe A/S Collapsible filter basket
US4836204A (en) * 1987-07-06 1989-06-06 Landymore Roderick W Method for effecting closure of a perforation in the septum of the heart
US4994069A (en) * 1988-11-02 1991-02-19 Target Therapeutics Vaso-occlusion coil and method
US5064435A (en) * 1990-06-28 1991-11-12 Schneider (Usa) Inc. Self-expanding prosthesis having stable axial length
US5108420A (en) * 1991-02-01 1992-04-28 Temple University Aperture occlusion device
US5108407A (en) * 1990-06-08 1992-04-28 Rush-Presbyterian St. Luke's Medical Center Method and apparatus for placement of an embolic coil
US5192301A (en) * 1989-01-17 1993-03-09 Nippon Zeon Co., Ltd. Closing plug of a defect for medical use and a closing plug device utilizing it
US5234458A (en) * 1990-06-15 1993-08-10 Antheor Filter device intended to prevent embolisms
US5382259A (en) * 1992-10-26 1995-01-17 Target Therapeutics, Inc. Vasoocclusion coil with attached tubular woven or braided fibrous covering
US5417708A (en) * 1994-03-09 1995-05-23 Cook Incorporated Intravascular treatment system and percutaneous release mechanism therefor
US5433727A (en) * 1994-08-16 1995-07-18 Sideris; Eleftherios B. Centering buttoned device for the occlusion of large defects for occluding
US5443478A (en) * 1992-09-02 1995-08-22 Board Of Regents, The University Of Texas System Multi-element intravascular occlusion device
US5451235A (en) * 1991-11-05 1995-09-19 C.R. Bard, Inc. Occluder and method for repair of cardiac and vascular defects
US5456693A (en) * 1992-09-21 1995-10-10 Vitaphore Corporation Embolization plugs for blood vessels
US5527338A (en) * 1992-09-02 1996-06-18 Board Of Regents, The University Of Texas System Intravascular device
US5549624A (en) * 1994-06-24 1996-08-27 Target Therapeutics, Inc. Fibered vasooclusion coils
US5562641A (en) * 1993-05-28 1996-10-08 A Bromberg & Co. Ltd. Two way shape memory alloy medical stent
US5578074A (en) * 1994-12-22 1996-11-26 Target Therapeutics, Inc. Implant delivery method and assembly
US5643317A (en) * 1992-11-25 1997-07-01 William Cook Europe S.A. Closure prosthesis for transcatheter placement
US5645558A (en) * 1995-04-20 1997-07-08 Medical University Of South Carolina Anatomically shaped vasoocclusive device and method of making the same
US5649949A (en) * 1996-03-14 1997-07-22 Target Therapeutics, Inc. Variable cross-section conical vasoocclusive coils
US5658308A (en) * 1995-12-04 1997-08-19 Target Therapeutics, Inc. Bioactive occlusion coil
US5690666A (en) * 1992-11-18 1997-11-25 Target Therapeutics, Inc. Ultrasoft embolism coils and process for using them
US5709707A (en) * 1995-10-30 1998-01-20 Children's Medical Center Corporation Self-centering umbrella-type septal closure device
US5749894A (en) * 1996-01-18 1998-05-12 Target Therapeutics, Inc. Aneurysm closure method
US5766160A (en) * 1995-06-06 1998-06-16 Target Therapeutics, Inc. Variable stiffness coils
US5830230A (en) * 1997-03-07 1998-11-03 Micro Therapeutics, Inc. Method of intracranial vascular embolotherapy using self anchoring coils
US5861003A (en) * 1996-10-23 1999-01-19 The Cleveland Clinic Foundation Apparatus and method for occluding a defect or aperture within body surface
US5879366A (en) * 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US5972026A (en) * 1997-04-07 1999-10-26 Broncus Technologies, Inc. Bronchial stenter having diametrically adjustable electrodes
US5976162A (en) * 1996-04-10 1999-11-02 Target Therapeutics, Inc. Soft-ended fibered micro vaso-occlusive devices
US5980554A (en) * 1997-05-05 1999-11-09 Micro Therapeutics, Inc. Wire frame partial flow obstruction for aneurysm treatment
US5980514A (en) * 1996-07-26 1999-11-09 Target Therapeutics, Inc. Aneurysm closure device assembly
US5993484A (en) * 1996-10-23 1999-11-30 United States Surgical Apparatus and method for dilatation of a body lumen and delivery of a prosthesis therein
US6010517A (en) * 1996-04-10 2000-01-04 Baccaro; Jorge Alberto Device for occluding abnormal vessel communications
US6024756A (en) * 1996-03-22 2000-02-15 Scimed Life Systems, Inc. Method of reversibly closing a septal defect
US6024765A (en) * 1996-12-30 2000-02-15 Target Therapeutics, Inc. Vaso-occlusive coil with conical end
US6033423A (en) * 1995-06-06 2000-03-07 Target Therapeutics, Inc. Multiple layered vaso-occlusive coils
US6036720A (en) * 1997-12-15 2000-03-14 Target Therapeutics, Inc. Sheet metal aneurysm neck bridge
US6059825A (en) * 1992-03-05 2000-05-09 Angiodynamics, Inc. Clot filter
US6063070A (en) * 1997-08-05 2000-05-16 Target Therapeutics, Inc. Detachable aneurysm neck bridge (II)
US6063104A (en) * 1998-06-24 2000-05-16 Target Therapeutics, Inc. Detachable, varying flexibility, aneurysm neck bridge
US6063100A (en) * 1998-03-10 2000-05-16 Cordis Corporation Embolic coil deployment system with improved embolic coil
US6074407A (en) * 1997-10-14 2000-06-13 Target Therapeutics, Inc. Delivery catheter for occlusive implants
US6117157A (en) * 1994-03-18 2000-09-12 Cook Incorporated Helical embolization coil
US6159165A (en) * 1997-12-05 2000-12-12 Micrus Corporation Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand
US6193708B1 (en) * 1997-08-05 2001-02-27 Scimed Life Systems, Inc. Detachable aneurysm neck bridge (I)
US6241691B1 (en) * 1997-12-05 2001-06-05 Micrus Corporation Coated superelastic stent
US6375671B1 (en) * 1999-04-19 2002-04-23 Nipro Corporation Closure device for transcatheter operations
US6790218B2 (en) * 1999-12-23 2004-09-14 Swaminathan Jayaraman Occlusive coil manufacture and delivery
US20050187564A1 (en) * 1999-12-23 2005-08-25 Swaminathan Jayaraman Occlusive coil manufacturing and delivery
US20070239199A1 (en) * 2006-03-31 2007-10-11 Swaminathan Jayaraman Inferior vena cava filter

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4339265A1 (en) * 1993-11-18 1995-05-24 Angiomed Ag Vena cava filters
US5466242A (en) * 1994-02-02 1995-11-14 Mori; Katsushi Stent for biliary, urinary or vascular system
US5882444A (en) * 1995-05-02 1999-03-16 Litana Ltd. Manufacture of two-way shape memory devices
GB9614950D0 (en) * 1996-07-16 1996-09-04 Anson Medical Ltd A ductus stent and delivery catheter

Patent Citations (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4619246A (en) * 1984-05-23 1986-10-28 William Cook, Europe A/S Collapsible filter basket
US4836204A (en) * 1987-07-06 1989-06-06 Landymore Roderick W Method for effecting closure of a perforation in the septum of the heart
US4994069A (en) * 1988-11-02 1991-02-19 Target Therapeutics Vaso-occlusion coil and method
US5192301A (en) * 1989-01-17 1993-03-09 Nippon Zeon Co., Ltd. Closing plug of a defect for medical use and a closing plug device utilizing it
US5108407A (en) * 1990-06-08 1992-04-28 Rush-Presbyterian St. Luke's Medical Center Method and apparatus for placement of an embolic coil
US5234458A (en) * 1990-06-15 1993-08-10 Antheor Filter device intended to prevent embolisms
US5064435A (en) * 1990-06-28 1991-11-12 Schneider (Usa) Inc. Self-expanding prosthesis having stable axial length
US5108420A (en) * 1991-02-01 1992-04-28 Temple University Aperture occlusion device
US5451235A (en) * 1991-11-05 1995-09-19 C.R. Bard, Inc. Occluder and method for repair of cardiac and vascular defects
US6059825A (en) * 1992-03-05 2000-05-09 Angiodynamics, Inc. Clot filter
US5443478A (en) * 1992-09-02 1995-08-22 Board Of Regents, The University Of Texas System Multi-element intravascular occlusion device
US5527338A (en) * 1992-09-02 1996-06-18 Board Of Regents, The University Of Texas System Intravascular device
US5456693A (en) * 1992-09-21 1995-10-10 Vitaphore Corporation Embolization plugs for blood vessels
US5382259A (en) * 1992-10-26 1995-01-17 Target Therapeutics, Inc. Vasoocclusion coil with attached tubular woven or braided fibrous covering
US5690666A (en) * 1992-11-18 1997-11-25 Target Therapeutics, Inc. Ultrasoft embolism coils and process for using them
US5643317A (en) * 1992-11-25 1997-07-01 William Cook Europe S.A. Closure prosthesis for transcatheter placement
US5562641A (en) * 1993-05-28 1996-10-08 A Bromberg & Co. Ltd. Two way shape memory alloy medical stent
US5417708A (en) * 1994-03-09 1995-05-23 Cook Incorporated Intravascular treatment system and percutaneous release mechanism therefor
US6117157A (en) * 1994-03-18 2000-09-12 Cook Incorporated Helical embolization coil
US5549624A (en) * 1994-06-24 1996-08-27 Target Therapeutics, Inc. Fibered vasooclusion coils
US5433727A (en) * 1994-08-16 1995-07-18 Sideris; Eleftherios B. Centering buttoned device for the occlusion of large defects for occluding
US5578074A (en) * 1994-12-22 1996-11-26 Target Therapeutics, Inc. Implant delivery method and assembly
US5645558A (en) * 1995-04-20 1997-07-08 Medical University Of South Carolina Anatomically shaped vasoocclusive device and method of making the same
US6033423A (en) * 1995-06-06 2000-03-07 Target Therapeutics, Inc. Multiple layered vaso-occlusive coils
US5766160A (en) * 1995-06-06 1998-06-16 Target Therapeutics, Inc. Variable stiffness coils
US5709707A (en) * 1995-10-30 1998-01-20 Children's Medical Center Corporation Self-centering umbrella-type septal closure device
US5658308A (en) * 1995-12-04 1997-08-19 Target Therapeutics, Inc. Bioactive occlusion coil
US5749894A (en) * 1996-01-18 1998-05-12 Target Therapeutics, Inc. Aneurysm closure method
US5649949A (en) * 1996-03-14 1997-07-22 Target Therapeutics, Inc. Variable cross-section conical vasoocclusive coils
US6024756A (en) * 1996-03-22 2000-02-15 Scimed Life Systems, Inc. Method of reversibly closing a septal defect
US5976162A (en) * 1996-04-10 1999-11-02 Target Therapeutics, Inc. Soft-ended fibered micro vaso-occlusive devices
US6010517A (en) * 1996-04-10 2000-01-04 Baccaro; Jorge Alberto Device for occluding abnormal vessel communications
US5980514A (en) * 1996-07-26 1999-11-09 Target Therapeutics, Inc. Aneurysm closure device assembly
US5993484A (en) * 1996-10-23 1999-11-30 United States Surgical Apparatus and method for dilatation of a body lumen and delivery of a prosthesis therein
US5861003A (en) * 1996-10-23 1999-01-19 The Cleveland Clinic Foundation Apparatus and method for occluding a defect or aperture within body surface
US5879366A (en) * 1996-12-20 1999-03-09 W.L. Gore & Associates, Inc. Self-expanding defect closure device and method of making and using
US6024765A (en) * 1996-12-30 2000-02-15 Target Therapeutics, Inc. Vaso-occlusive coil with conical end
US5830230A (en) * 1997-03-07 1998-11-03 Micro Therapeutics, Inc. Method of intracranial vascular embolotherapy using self anchoring coils
US6126672A (en) * 1997-03-07 2000-10-03 Micro Therapeutics, Inc. Method of intracranial vascular embolotherapy using self anchoring coils
US5972026A (en) * 1997-04-07 1999-10-26 Broncus Technologies, Inc. Bronchial stenter having diametrically adjustable electrodes
US5980554A (en) * 1997-05-05 1999-11-09 Micro Therapeutics, Inc. Wire frame partial flow obstruction for aneurysm treatment
US6193708B1 (en) * 1997-08-05 2001-02-27 Scimed Life Systems, Inc. Detachable aneurysm neck bridge (I)
US6063070A (en) * 1997-08-05 2000-05-16 Target Therapeutics, Inc. Detachable aneurysm neck bridge (II)
US6074407A (en) * 1997-10-14 2000-06-13 Target Therapeutics, Inc. Delivery catheter for occlusive implants
US6159165A (en) * 1997-12-05 2000-12-12 Micrus Corporation Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand
US6241691B1 (en) * 1997-12-05 2001-06-05 Micrus Corporation Coated superelastic stent
US6036720A (en) * 1997-12-15 2000-03-14 Target Therapeutics, Inc. Sheet metal aneurysm neck bridge
US6063100A (en) * 1998-03-10 2000-05-16 Cordis Corporation Embolic coil deployment system with improved embolic coil
US6063104A (en) * 1998-06-24 2000-05-16 Target Therapeutics, Inc. Detachable, varying flexibility, aneurysm neck bridge
US6375671B1 (en) * 1999-04-19 2002-04-23 Nipro Corporation Closure device for transcatheter operations
US6790218B2 (en) * 1999-12-23 2004-09-14 Swaminathan Jayaraman Occlusive coil manufacture and delivery
US20050187564A1 (en) * 1999-12-23 2005-08-25 Swaminathan Jayaraman Occlusive coil manufacturing and delivery
US20070239199A1 (en) * 2006-03-31 2007-10-11 Swaminathan Jayaraman Inferior vena cava filter

Cited By (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050187564A1 (en) * 1999-12-23 2005-08-25 Swaminathan Jayaraman Occlusive coil manufacturing and delivery
US7901428B2 (en) 2000-01-05 2011-03-08 Integrated Vascular Systems, Inc. Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US8758400B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Closure system and methods of use
US9579091B2 (en) 2000-01-05 2017-02-28 Integrated Vascular Systems, Inc. Closure system and methods of use
US8956388B2 (en) 2000-01-05 2015-02-17 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant
US20030078598A1 (en) * 2000-01-05 2003-04-24 Integrated Vascular Systems, Inc. Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US7931669B2 (en) 2000-01-05 2011-04-26 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant and methods of use
US8758396B2 (en) 2000-01-05 2014-06-24 Integrated Vascular Systems, Inc. Vascular sheath with bioabsorbable puncture site closure apparatus and methods of use
US20020133193A1 (en) * 2000-01-05 2002-09-19 Ginn Richard S. Integrated vascular device with puncture site closure component and sealant and methods of use
US9050087B2 (en) 2000-01-05 2015-06-09 Integrated Vascular Systems, Inc. Integrated vascular device with puncture site closure component and sealant and methods of use
US9060769B2 (en) 2000-09-08 2015-06-23 Abbott Vascular Inc. Surgical stapler
US9402625B2 (en) 2000-09-08 2016-08-02 Abbott Vascular Inc. Surgical stapler
US20090230168A1 (en) * 2000-09-08 2009-09-17 Abbott Vascular Inc. Surgical stapler
US20080272173A1 (en) * 2000-09-08 2008-11-06 Abbott Vascular Inc. Surgical stapler
US8784447B2 (en) 2000-09-08 2014-07-22 Abbott Vascular Inc. Surgical stapler
US20070010853A1 (en) * 2000-10-06 2007-01-11 Integrated Vascular Systems, Inc. Apparatus and methods for positioning a vascular sheath
US9089674B2 (en) 2000-10-06 2015-07-28 Integrated Vascular Systems, Inc. Apparatus and methods for positioning a vascular sheath
US20110144668A1 (en) * 2000-12-07 2011-06-16 Integrated Vascular Systems, Inc. Closure device
US8182497B2 (en) 2000-12-07 2012-05-22 Integrated Vascular Systems, Inc. Closure device
US8236026B2 (en) 2000-12-07 2012-08-07 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8690910B2 (en) 2000-12-07 2014-04-08 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8257390B2 (en) 2000-12-07 2012-09-04 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US9320522B2 (en) 2000-12-07 2016-04-26 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8603136B2 (en) 2000-12-07 2013-12-10 Integrated Vascular Systems, Inc. Apparatus and methods for providing tactile feedback while delivering a closure device
US20070276416A1 (en) * 2000-12-07 2007-11-29 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US20030195561A1 (en) * 2000-12-07 2003-10-16 Carley Michael T. Closure device and methods for making and using them
US8597325B2 (en) 2000-12-07 2013-12-03 Integrated Vascular Systems, Inc. Apparatus and methods for providing tactile feedback while delivering a closure device
US9585646B2 (en) 2000-12-07 2017-03-07 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US20110071565A1 (en) * 2000-12-07 2011-03-24 Integrated Vascular Systems, Inc. Apparatus and methods for providing tactile feedback while delivering a closure device
US8486108B2 (en) 2000-12-07 2013-07-16 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8486092B2 (en) 2000-12-07 2013-07-16 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US7879071B2 (en) 2000-12-07 2011-02-01 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US7887555B2 (en) 2000-12-07 2011-02-15 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US9554786B2 (en) 2000-12-07 2017-01-31 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8128644B2 (en) 2000-12-07 2012-03-06 Integrated Vascular Systems, Inc. Closure device and methods for making and using them
US8728119B2 (en) 2001-06-07 2014-05-20 Abbott Vascular Inc. Surgical staple
US20070010854A1 (en) * 2001-06-07 2007-01-11 Christy Cummins Surgical Staple
US7918873B2 (en) 2001-06-07 2011-04-05 Abbott Vascular Inc. Surgical staple
US8579932B2 (en) 2002-02-21 2013-11-12 Integrated Vascular Systems, Inc. Sheath apparatus and methods for delivering a closure device
US9498196B2 (en) 2002-02-21 2016-11-22 Integrated Vascular Systems, Inc. Sheath apparatus and methods for delivering a closure device
US8007512B2 (en) 2002-02-21 2011-08-30 Integrated Vascular Systems, Inc. Plunger apparatus and methods for delivering a closure device
US8469995B2 (en) 2002-06-04 2013-06-25 Abbott Vascular Inc. Blood vessel closure clip and delivery device
US9980728B2 (en) 2002-06-04 2018-05-29 Abbott Vascular Inc Blood vessel closure clip and delivery device
US8192459B2 (en) 2002-06-04 2012-06-05 Abbott Vascular Inc. Blood vessel closure clip and delivery device
US20110144663A1 (en) * 2002-06-04 2011-06-16 Abbott Vascular Inc. Blood Vessel Closure Clip and Delivery Device
US9295469B2 (en) 2002-06-04 2016-03-29 Abbott Vascular Inc. Blood vessel closure clip and delivery device
US20110060355A1 (en) * 2002-12-31 2011-03-10 Integrated Vacular Systems, Inc. Methods for manufacturing a clip and clip
US8202283B2 (en) 2002-12-31 2012-06-19 Integrated Vascular Systems, Inc. Methods for manufacturing a clip and clip
US8585836B2 (en) 2002-12-31 2013-11-19 Integrated Vascular Systems, Inc. Methods for manufacturing a clip and clip
US20110144664A1 (en) * 2003-01-30 2011-06-16 Integrated Vascular Systems, Inc. Clip applier and methods of use
US20080312666A1 (en) * 2003-01-30 2008-12-18 Abbott Laboratories Clip applier and methods of use
US20040153122A1 (en) * 2003-01-30 2004-08-05 Integrated Vascular Systems, Inc. Clip applier and methods of use
US20110230897A1 (en) * 2003-01-30 2011-09-22 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8202294B2 (en) 2003-01-30 2012-06-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8202293B2 (en) 2003-01-30 2012-06-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US9398914B2 (en) 2003-01-30 2016-07-26 Integrated Vascular Systems, Inc. Methods of use of a clip applier
US8926656B2 (en) 2003-01-30 2015-01-06 Integated Vascular Systems, Inc. Clip applier and methods of use
US8398656B2 (en) 2003-01-30 2013-03-19 Integrated Vascular Systems, Inc. Clip applier and methods of use
US8529587B2 (en) 2003-01-30 2013-09-10 Integrated Vascular Systems, Inc. Methods of use of a clip applier
US9271707B2 (en) 2003-01-30 2016-03-01 Integrated Vascular Systems, Inc. Clip applier and methods of use
US9924948B2 (en) 2003-07-28 2018-03-27 Baronova, Inc. Gastric retaining devices and methods
US20070178160A1 (en) * 2003-07-28 2007-08-02 Baronova, Inc. Gastro-intestinal device and method for treating addiction
US9931122B2 (en) 2003-07-28 2018-04-03 Baronova, Inc. Gastric retaining devices and methods
US20070135831A1 (en) * 2003-07-28 2007-06-14 Baronova, Inc. Pyloric valve corking device
US9642735B2 (en) 2003-07-28 2017-05-09 Baronova, Inc. Pyloric valve corking device
US8663338B2 (en) 2003-07-28 2014-03-04 Baronova, Inc. Pyloric valve obstructing devices and methods
US20050055039A1 (en) * 2003-07-28 2005-03-10 Polymorfix, Inc. Devices and methods for pyloric anchoring
US9687243B2 (en) 2003-07-28 2017-06-27 Baronova, Inc. Gastric retaining devices and methods
US9700450B2 (en) 2003-07-28 2017-07-11 Baronova, Inc. Devices and methods for gastrointestinal stimulation
US20070250132A1 (en) * 2003-07-28 2007-10-25 Baronova, Inc. Devices and methods for gastrointestinal stimulation
US8821521B2 (en) 2003-07-28 2014-09-02 Baronova, Inc. Gastro-intestinal device and method for treating addiction
US9510834B2 (en) 2003-07-28 2016-12-06 Baronova, Inc. Gastric retaining devices and methods
US20090187201A1 (en) * 2003-07-28 2009-07-23 Daniel Rogers Burnett Gastric retaining devices and methods
US8657885B2 (en) 2003-07-28 2014-02-25 Baronova, Inc. Pyloric valve obstructing devices and methods
US20090187200A1 (en) * 2003-07-28 2009-07-23 Daniel Rogers Burnett Gastric retaining devices and methods
US9498366B2 (en) 2003-07-28 2016-11-22 Baronova, Inc. Devices and methods for pyloric anchoring
US8590760B2 (en) 2004-05-25 2013-11-26 Abbott Vascular Inc. Surgical stapler
US20100241120A1 (en) * 2004-10-04 2010-09-23 Saint Louis University Intramedullary nail device and method for repairing long bone
US8926633B2 (en) 2005-06-24 2015-01-06 Abbott Laboratories Apparatus and method for delivering a closure element
US9050068B2 (en) 2005-07-01 2015-06-09 Abbott Laboratories Clip applier and methods of use
US8313497B2 (en) 2005-07-01 2012-11-20 Abbott Laboratories Clip applier and methods of use
US10085753B2 (en) 2005-07-01 2018-10-02 Abbott Laboratories Clip applier and methods of use
US8518057B2 (en) 2005-07-01 2013-08-27 Abbott Laboratories Clip applier and methods of use
US9456811B2 (en) 2005-08-24 2016-10-04 Abbott Vascular Inc. Vascular closure methods and apparatuses
US8920442B2 (en) 2005-08-24 2014-12-30 Abbott Vascular Inc. Vascular opening edge eversion methods and apparatuses
US20070083230A1 (en) * 2005-10-07 2007-04-12 Alex Javois Left atrial appendage occlusion device
US20070239199A1 (en) * 2006-03-31 2007-10-11 Swaminathan Jayaraman Inferior vena cava filter
US8808310B2 (en) 2006-04-20 2014-08-19 Integrated Vascular Systems, Inc. Resettable clip applier and reset tools
US8556930B2 (en) * 2006-06-28 2013-10-15 Abbott Laboratories Vessel closure device
US20080004640A1 (en) * 2006-06-28 2008-01-03 Abbott Laboratories Vessel closure device
US9962144B2 (en) 2006-06-28 2018-05-08 Abbott Laboratories Vessel closure device
US8758398B2 (en) 2006-09-08 2014-06-24 Integrated Vascular Systems, Inc. Apparatus and method for delivering a closure element
US20080319475A1 (en) * 2007-06-25 2008-12-25 Abbott Laboratories Methods, Devices, and Apparatus for Managing Access Through Tissue
US8226681B2 (en) 2007-06-25 2012-07-24 Abbott Laboratories Methods, devices, and apparatus for managing access through tissue
DE102007032339A1 (en) * 2007-07-11 2009-01-15 Acandis Gmbh & Co. Kg Surgical implant for the closure of an endo-vascular aneurism has two truncated cones joined at apex
DE102007032339B4 (en) * 2007-07-11 2010-03-25 Acandis Gmbh & Co. Kg Device for closing of vascular aneurysms
US8888797B2 (en) 2007-09-07 2014-11-18 Baronova, Inc. Device for intermittently obstructing a gastric opening and method of use
US9504591B2 (en) 2007-09-07 2016-11-29 Baronova, Inc. Device for intermittently obstructing a gastric opening and method of use
US8821584B2 (en) * 2007-09-07 2014-09-02 Baronova, Inc. Device for intermittently obstructing a gastric opening and method of use
US8795301B2 (en) 2007-09-07 2014-08-05 Baronova, Inc. Device for intermittently obstructing a gastric opening and method of use
US20090182357A1 (en) * 2007-09-07 2009-07-16 Baronova, Inc. Device for intermittently obstructing a gastric opening and method of use
US20090198210A1 (en) * 2007-09-07 2009-08-06 Baronova, Inc. Device for intermittently obstructing a gastric opening and method of use
US20090182358A1 (en) * 2007-09-07 2009-07-16 Baronova.Inc. Device for intermittently obstructing a gastric opening and method of use
US8672953B2 (en) 2007-12-17 2014-03-18 Abbott Laboratories Tissue closure system and methods of use
US8893947B2 (en) 2007-12-17 2014-11-25 Abbott Laboratories Clip applier and methods of use
US8820602B2 (en) 2007-12-18 2014-09-02 Abbott Laboratories Modular clip applier
WO2009099437A1 (en) * 2008-02-05 2009-08-13 Boston Scientific Limited Apparatus and method for closing an opening in a blood vessel using memory metal and collagen
US9282965B2 (en) 2008-05-16 2016-03-15 Abbott Laboratories Apparatus and methods for engaging tissue
US8398676B2 (en) 2008-10-30 2013-03-19 Abbott Vascular Inc. Closure device
US8657852B2 (en) 2008-10-30 2014-02-25 Abbott Vascular Inc. Closure device
US9241696B2 (en) 2008-10-30 2016-01-26 Abbott Vascular Inc. Closure device
US20100114159A1 (en) * 2008-10-30 2010-05-06 Abbott Vascular Inc. Closure device
US20100160958A1 (en) * 2008-12-22 2010-06-24 Abbott Laboratories Closure Device
US8323312B2 (en) 2008-12-22 2012-12-04 Abbott Laboratories Closure device
US8858594B2 (en) 2008-12-22 2014-10-14 Abbott Laboratories Curved closure device
US20100179571A1 (en) * 2009-01-09 2010-07-15 Abbott Vascular Inc. Closure devices, systems, and methods
US9414820B2 (en) 2009-01-09 2016-08-16 Abbott Vascular Inc. Closure devices, systems, and methods
US9173644B2 (en) 2009-01-09 2015-11-03 Abbott Vascular Inc. Closure devices, systems, and methods
US9486191B2 (en) 2009-01-09 2016-11-08 Abbott Vascular, Inc. Closure devices
US9314230B2 (en) 2009-01-09 2016-04-19 Abbott Vascular Inc. Closure device with rapidly eroding anchor
US9089311B2 (en) 2009-01-09 2015-07-28 Abbott Vascular Inc. Vessel closure devices and methods
US9414824B2 (en) 2009-01-16 2016-08-16 Abbott Vascular Inc. Closure devices, systems, and methods
US8905937B2 (en) 2009-02-26 2014-12-09 Integrated Vascular Systems, Inc. Methods and apparatus for locating a surface of a body lumen
US9808252B2 (en) 2009-04-02 2017-11-07 Endoshape, Inc. Vascular occlusion devices
US9585647B2 (en) 2009-08-26 2017-03-07 Abbott Laboratories Medical device for repairing a fistula
US9539082B2 (en) * 2009-11-24 2017-01-10 Emory University Tissue support structure
US20130073054A1 (en) * 2009-11-24 2013-03-21 Georgia Tech Research Corporation Tissue support structure
WO2011084536A3 (en) * 2009-12-16 2011-11-03 Endoshape, Inc. Multi-fiber shape memory device
US8303624B2 (en) 2010-03-15 2012-11-06 Abbott Cardiovascular Systems, Inc. Bioabsorbable plug
US8828051B2 (en) 2010-07-02 2014-09-09 Pfm Medical Ag Left atrial appendage occlusion device
US8758399B2 (en) 2010-08-02 2014-06-24 Abbott Cardiovascular Systems, Inc. Expandable bioabsorbable plug apparatus and method
US8603116B2 (en) 2010-08-04 2013-12-10 Abbott Cardiovascular Systems, Inc. Closure device with long tines
US8821534B2 (en) 2010-12-06 2014-09-02 Integrated Vascular Systems, Inc. Clip applier having improved hemostasis and methods of use
US20120158034A1 (en) * 2010-12-16 2012-06-21 Wilson Thomas S Expandable Implant and Implant System
US10010327B2 (en) * 2010-12-16 2018-07-03 Lawrence Livermore National Security, Llc Expandable implant and implant system
US9936955B2 (en) 2011-01-11 2018-04-10 Amsel Medical Corporation Apparatus and methods for fastening tissue layers together with multiple tissue fasteners
US10076339B2 (en) 2011-01-11 2018-09-18 Amsel Medical Corporation Method and apparatus for clamping tissue layers and occluding tubular body lumens
US9149276B2 (en) 2011-03-21 2015-10-06 Abbott Cardiovascular Systems, Inc. Clip and deployment apparatus for tissue closure
US9332976B2 (en) 2011-11-30 2016-05-10 Abbott Cardiovascular Systems, Inc. Tissue closure device
US9364209B2 (en) 2012-12-21 2016-06-14 Abbott Cardiovascular Systems, Inc. Articulating suturing device
US10070981B2 (en) 2013-03-15 2018-09-11 Baronova, Inc. Locking gastric obstruction device and method of use
US9848883B2 (en) 2013-07-31 2017-12-26 EMBA Medical Limited Methods and devices for endovascular embolization
US9681876B2 (en) 2013-07-31 2017-06-20 EMBA Medical Limited Methods and devices for endovascular embolization
US10010328B2 (en) 2013-07-31 2018-07-03 NeuVT Limited Endovascular occlusion device with hemodynamically enhanced sealing and anchoring
US10111664B2 (en) 2014-06-23 2018-10-30 Integrated Vascular Systems, Inc. Closure system and methods of use
US10028733B2 (en) 2015-05-28 2018-07-24 National University Of Ireland, Galway Fistula treatment device
WO2018035167A1 (en) * 2016-08-16 2018-02-22 Spartan Micro, Inc. Intravascular flow diversion devices
US9848906B1 (en) 2017-06-20 2017-12-26 Joe Michael Eskridge Stent retriever having an expandable fragment guard

Also Published As

Publication number Publication date Type
EP1239780A4 (en) 2006-05-03 application
JP2003517869A (en) 2003-06-03 application
DE60040165D1 (en) 2008-10-16 grant
WO2001045571A1 (en) 2001-06-28 application
EP1239780A1 (en) 2002-09-18 application
EP1239780B1 (en) 2008-09-03 grant
US20020010481A1 (en) 2002-01-24 application
US6790218B2 (en) 2004-09-14 grant
CA2394581A1 (en) 2001-06-28 application
DK1239780T3 (en) 2009-01-19 grant
CA2394581C (en) 2009-11-24 grant

Similar Documents

Publication Publication Date Title
US6929654B2 (en) Non-overlapping spherical three-dimensional coil
US5549624A (en) Fibered vasooclusion coils
US6994717B2 (en) Occlusion method and apparatus
US7896899B2 (en) Metallic coils enlaced with biological or biodegradable or synthetic polymers or fibers for embolization of a body cavity
US7033374B2 (en) Microcoil vaso-occlusive device with multi-axis secondary configuration
US8034061B2 (en) Percutaneous catheter directed intravascular occlusion devices
US6383204B1 (en) Variable stiffness coil for vasoocclusive devices
US8398670B2 (en) Multi-layer braided structures for occluding vascular defects and for occluding fluid flow through portions of the vasculature of the body
US6090125A (en) Anatomically shaped vasoocclusive device and method of making the same
US6117157A (en) Helical embolization coil
US6168570B1 (en) Micro-strand cable with enhanced radiopacity
US8142456B2 (en) Braid-ball embolic devices
US20020173839A1 (en) Intravascular flow modifier and reinforcement device with connected segments
US20120172927A1 (en) Left atrial appendage occlusive devices
US20080306503A1 (en) Mechanically detachable vaso-occlusive device
US5911731A (en) Anatomically shaped vasoocclusive devices
US20090112251A1 (en) Braided occlusion device having repeating expanded volume segments separated by articulation segments
US6159165A (en) Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand
US20090171386A1 (en) Percutaneous catheter directed intravascular occlusion devices
US5846261A (en) Percutaneous catheter directed occlusion devices
US5944738A (en) Percutaneous catheter directed constricting occlusion device
US8623071B2 (en) Radiopaque super-elastic intravascular stent
US6544275B1 (en) Vaso-occlusive coils with selectively flattened areas
US6001092A (en) Complex coils having fibered centers
US20050228434A1 (en) Multi-layer braided structures for occluding vascular defects