US20050006255A1 - Contact lens packages containing additives - Google Patents
Contact lens packages containing additives Download PDFInfo
- Publication number
- US20050006255A1 US20050006255A1 US10/731,258 US73125803A US2005006255A1 US 20050006255 A1 US20050006255 A1 US 20050006255A1 US 73125803 A US73125803 A US 73125803A US 2005006255 A1 US2005006255 A1 US 2005006255A1
- Authority
- US
- United States
- Prior art keywords
- package
- pvp
- concentration
- average roughness
- maleic anhydride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45C—PURSES; LUGGAGE; HAND CARRIED BAGS
- A45C11/00—Receptacles for purposes not provided for in groups A45C1/00-A45C9/00
- A45C11/005—Contact lens cases
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- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45C—PURSES; LUGGAGE; HAND CARRIED BAGS
- A45C11/00—Receptacles for purposes not provided for in groups A45C1/00-A45C9/00
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45C—PURSES; LUGGAGE; HAND CARRIED BAGS
- A45C11/00—Receptacles for purposes not provided for in groups A45C1/00-A45C9/00
- A45C11/04—Spectacle cases; Pince-nez cases
-
- A—HUMAN NECESSITIES
- A45—HAND OR TRAVELLING ARTICLES
- A45C—PURSES; LUGGAGE; HAND CARRIED BAGS
- A45C11/00—Receptacles for purposes not provided for in groups A45C1/00-A45C9/00
- A45C11/04—Spectacle cases; Pince-nez cases
- A45C11/046—Spectacle cases; Pince-nez cases with contact lens holders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/086—Container, accessories or devices therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B25/00—Packaging other articles presenting special problems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B25/00—Packaging other articles presenting special problems
- B65B25/008—Packaging other articles presenting special problems packaging of contact lenses
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
- B65B55/22—Immersing contents in protective liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
Definitions
- This invention related to packages for storing contact lenses as well as methods of using and preparing these packages.
- FIG. 1 illustrates the data for Lens A in different packages
- FIG. 2 illustrates the data for Lens B in different packages
- FIG. 3 illustrates the data for Lens C in different packages
- This invention includes a package for storing medical devices in a solution comprising, consisting essentially of, or consisting of, a molded base wherein the molded base comprises an additive, provided that the medical device is not a contact lens consisting of acqualfilcon A coated with polyHema.
- a “medical device” is any device that is stored or packaged in a solution and is used to treat a human disease.
- medical devices include but are not limited to ophthalmic devices that reside in or on the eye.
- Ophthalmic devices includes but are not limited to soft contact lenses, intraocular lenses, overlay lenses, ocular inserts, and optical inserts. These devices can provide optical correction or may be cosmetic.
- the preferred medical devices of the invention are soft contact lenses made from silicone elastomers or hydrogels, which include but are not limited to silicone hydrogels, and fluorohydrogels.
- Soft contact lens formulations are disclosed in U.S.
- the particularly preferred medical devices of the invention are soft contact lenses made from etafilcon A, genfilcon A, lenefilcon A, polymacon, balafilcon A, lotrafilcon A. and silicone hydrogels as prepared in U.S. Pat. No. 5,998,498, U.S. patent application Ser. No. 09/532,943, a continuation-in-part of U.S. patent application Ser. No. 09/532,943, filed on Aug. 30, 2000, U.S. Pat. No. 6,087,415, U.S. Pat. No. 5,760,100, U.S. Pat. No. 5,776, 999, U.S. Pat. No. 5,789,461, U.S. Pat. No.
- the more particularly preferred medical devices of the invention are soft contact lenses, balafilcon A, lotrafilcon A, galyfilcon A, senofilcon A, or those made as described in U.S. patent application Ser. No. 60/318,536, entitled Biomedical Devices Containing Internal wetting Agents,” filed on Sep. 10, 2001 and its non-provisional counterpart of the same title, filed on Sep. 6, 2002.
- the most particularly preferred medical devices are soft contact lenses made from either galyfilcon A or senofilcon A.
- molded base refers to any polymer, rubber, or plastic that can be formed into a receptacle for medical devices, where the size and shape of the base are determined by the device and other considerations known those who are skilled in the art of making or designing molded bases.
- molded bases may be individual blister packages, secondary packages, or hydrating trays.
- the molded base may be prepared from any number of materials provided that those materials are compatible with the chemical and physical properties of the device. Examples of suitable materials include but are not limited to polypropylene, polyethylene, nylons, olefin co-polymers, acrylics, rubbers, urethanes, polycarbonates, or fluorocarbons.
- the preferred materials are metallocenes polymers and co-polymers made of polypropylene, polyethylene, having a melt flow range of about 15 g/10 minutes to about 44 g/10 minutes as determined by ASTM D-1238.
- examples of suitably shaped bases are disclosed in the following patents which are hereby incorporated by reference in their entirety, U.S. Pat. Nos.
- Flexible cover sheets can be made from can be an adhesive laminate of an aluminum foil and a polypropylene film or any other extruded or co-extruded film that can be sealed to the top surface of the flange in order to form a hermetic seal for the medical device and the solution.
- the base can be formed by any of a number of known methods which include but are not limited to injection molding, transfer molding, skin packaging, blow molding, coinjection molding, film extrusion, or film co-extrusion.
- additive refers to a substance that is added to the polymer, rubber, or plastic prior to forming the molded base, where the material inhibits sticking, adherence, or adhesion of the medical device to the molded base.
- the additive is mixed with the remainder of the molded base material and amount of additive present by weight percentage based on the total weight of the molded base material is greater than about 0.25 to about 10 weight percent, preferably greater than about 0.25 to about 5 weight percent, most preferably about 0.25 to about 3 weight percent.
- the preferred additives are glycerol monostearate (2%), polyvinylpyrolidone (1% to 5%), polyvinylpyrolidone/maleic anhydride (1/1% to 5/5%), and succinic acid (5%).
- Polyvinylpyrolidinone has a variety of molecular weight ranges (as indicated by the KD#) and consistencies (flake, powdered/micronized). When PVP KD90 is used as an additive, it is preferred that it is powered/micronized.
- solution refers to any liquid medium in which a medical device is stored.
- the preferred solutions are aqueous solutions contain physiological buffers.
- the particularly preferred solution is saline solution.
- the medical device is a contact lens
- the molded base is transparent to the degree necessary to permit visual inspection, UV sterilization or both.
- the preferred additives are glycerol monostearate present at about 2 weight percent, succininc acid present at about 5 weight percent, PVP KD90 present at about 1-5 weight percent, PVP/maleic anhydride present at about 1/1 to about 5/5 weight percent. If the inner surface of the medical device has a roughness of about 0.2 ⁇ m to about 4.5 ⁇ m, the preferred additives are maleic anhydride or PVP/maleic anhydride, most preferably maleic anhydride.
- the invention includes a method of reducing the adherence of a medical device to its packaging, comprising, consisting essentially of, or consisting of, storing said medical device in a solution in a package comprising, consisting essentially of, or consisting of, a molded base wherein said molded base comprises an additive, provided that the medical device is not a contact lens consisting of acqualfilcon A coated with polyHema.
- molded base, medical device, solution and additive all have their aforementioned meanings and preferred ranges.
- soft contact lenses When soft contact lenses are prepared, the lenses cured to a hard disc and subsequently hydrated with water to give the non-sterilized final product. During this hydration step, soft contact lenses often stick to the surface of the hydration chamber and it would useful to find a method of hydrating soft contact lenses which alleviates this problem.
- the invention includes a method of hydrating a contact lens comprising, consisting essentially of, or consisting of hydrating said lens in a molded base wherein said molded base comprises an additive.
- molded base, medical device, solution and additive all have their aforementioned meanings.
- the preferred values for the medical device, the solution and the additive are as listed above.
- the preferred molded base is a square or a rectangle.
- Ampacet 40604 fatty acid amide ATOFINA Finacene Nucleated polypropylene having a melt 3924CWZ flow of 55 g/10 minutes, ASTM D1238.
- This material contains an antistat and a lubricant Atmer 163 fatty alkyl diethanolamine Reg. No. 107043-84-5 Dow Siloxane a silicone dispersion MB50-321 Epolene E43-Wax, maleic anhydride produced by Eastman Chemical Erucamide fatty acid amide Registry No.
- Lens C Contact lenses prepared as described in U.S. Pat. App. No. 60/318,536, entitled Biomedical Devices Containing Internal wetting Agents,” filed on September 10, 2001 and its non-provisional counterpart of the same title, filed on September 6, 2002, containing by weight percent 28% Simma 2, 31% mPDMS, 23.5% DMA, 7% PVP (MW 360,000), 1.5% TEDGMA, 0.98% CGI 1850, 2.0% Norbloc, 6 HEMA, 0.02% Blue Hema.
- Additives (identity and amounts listed in Table 1) were mixed with polypropylene (listed below).
- the material was injection molded to form the base portion of a contact lens package.
- the configuration of the package is as illustrated in FIG. 1 of U.S. Pat. No. 5,467,868 which is hereby incorporated by reference.
- Packages containing 2% weight percent GMS and Exxon 1605 were prepared using the method of Example 1. Contact lenses of types A, B, and C were added to individual blister packages along with 950 ⁇ L of saline solution. The filed packages were heat sealed with flexible covers and sterilized. The packaged lenses were submitted to consumers. The consumers opened the packages and evaluated the lenses for ease of removal of the lens from the package using the following criteria and grading system
- FIG. 1 illustrates the testing results for a comparison of Lens A in a polypropylene package (control), Lens A in a package containing 2.0% GMS where the package has an average surface roughness (Ra) of about 2.0 ⁇ m, and Len A in a package containing 2.0% GMS. This figure shows that the roughened package containing GMS has the highest consumer rating.
- FIG. 2 illustrates the testing results for a comparison of Lens B in a polypropylene package (control), Lens B in a package containing 2.0% GMS where the package has an average surface roughness (Ra) of about 2.0 am, and Len B in a package containing 2.0% GMS. This figure shows that the package containing 2.0%GMS has the highest consumer rating.
- FIG. 3 illustrates the testing results for a comparison of Lens C in a polypropylene package (control), Lens C in a package containing 2.0% GMS where the package has an average surface roughness (Ra) of about 2.0 ⁇ m, and Len C in a package containing 2.0% GMS. This figure shows that the package containing 2.0% GMS has the highest consumer rating.
- Example 1 The testing methods and preparations of Example 1 were repeated with different additives and lens types as per Table 2. If “(UP)” appears in an entry, that bowl of the blister is shaped as in U.S. Pat. No. D 458,023. When the term “Rough Bowl” appears, the inside surface of the bowl is roughened to an Ra of 0.5 mm to 0.8 mm.
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- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Eyeglasses (AREA)
- Packaging Frangible Articles (AREA)
- Packages (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/731,258 US20050006255A1 (en) | 2002-12-23 | 2003-12-09 | Contact lens packages containing additives |
US12/342,506 US20090165427A1 (en) | 2002-12-23 | 2008-12-23 | Contact lens packages containing additives |
US14/594,558 US20150121809A1 (en) | 2002-12-23 | 2015-01-12 | Contact lens packages containing additives |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43610902P | 2002-12-23 | 2002-12-23 | |
US10/731,258 US20050006255A1 (en) | 2002-12-23 | 2003-12-09 | Contact lens packages containing additives |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/342,506 Division US20090165427A1 (en) | 2002-12-23 | 2008-12-23 | Contact lens packages containing additives |
Publications (1)
Publication Number | Publication Date |
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US20050006255A1 true US20050006255A1 (en) | 2005-01-13 |
Family
ID=32713054
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/731,258 Abandoned US20050006255A1 (en) | 2002-12-23 | 2003-12-09 | Contact lens packages containing additives |
US12/342,506 Abandoned US20090165427A1 (en) | 2002-12-23 | 2008-12-23 | Contact lens packages containing additives |
US14/594,558 Abandoned US20150121809A1 (en) | 2002-12-23 | 2015-01-12 | Contact lens packages containing additives |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/342,506 Abandoned US20090165427A1 (en) | 2002-12-23 | 2008-12-23 | Contact lens packages containing additives |
US14/594,558 Abandoned US20150121809A1 (en) | 2002-12-23 | 2015-01-12 | Contact lens packages containing additives |
Country Status (13)
Country | Link |
---|---|
US (3) | US20050006255A1 (fr) |
EP (10) | EP2283876A1 (fr) |
JP (1) | JP4776926B2 (fr) |
KR (1) | KR101229813B1 (fr) |
CN (1) | CN100384484C (fr) |
AR (1) | AR043320A1 (fr) |
AU (2) | AU2003296355B2 (fr) |
BR (1) | BR0317631B1 (fr) |
CA (3) | CA2510567C (fr) |
DE (1) | DE60331170D1 (fr) |
HK (4) | HK1080399A1 (fr) |
TW (1) | TWI350187B (fr) |
WO (1) | WO2004060099A2 (fr) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080015315A1 (en) * | 2006-07-12 | 2008-01-17 | Frank Chang | Novel Polymers |
US20080143958A1 (en) * | 2006-12-13 | 2008-06-19 | Arturo Norberto Medina | Production of ophthalmic devices based on photo-induced step growth polymerization |
US20080174035A1 (en) * | 2006-06-08 | 2008-07-24 | Lynn Cook Winterton | Silicone hydrogel contact lenses |
US20090059165A1 (en) * | 2007-08-31 | 2009-03-05 | John Dallas Pruitt | Contact lens products |
US20090057164A1 (en) * | 2007-08-31 | 2009-03-05 | Kasey Jon Minick | Contact lens packaging solutions |
US20090086160A1 (en) * | 2007-09-28 | 2009-04-02 | Enns John B | Methods of sterilizing ophthalmic lenses |
US8051978B2 (en) | 2008-10-21 | 2011-11-08 | Menicon Co., Ltd. | Contact lens storage container |
US9829723B2 (en) | 2015-12-03 | 2017-11-28 | Novartis Ag | Contact lens packaging solutions |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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US20050205451A1 (en) * | 2004-03-18 | 2005-09-22 | Brown-Skrobot Susan K | Contact lens packages |
US20060051454A1 (en) * | 2004-08-26 | 2006-03-09 | Ansell Scott F | Molds for producing ophthalmic lenses |
US7426993B2 (en) | 2005-08-09 | 2008-09-23 | Coopervision International Holding Company, Lp | Contact lens package |
US8414804B2 (en) | 2006-03-23 | 2013-04-09 | Johnson & Johnson Vision Care, Inc. | Process for making ophthalmic lenses |
US7572841B2 (en) | 2006-06-15 | 2009-08-11 | Coopervision International Holding Company, Lp | Wettable silicone hydrogel contact lenses and related compositions and methods |
US7540609B2 (en) | 2006-06-15 | 2009-06-02 | Coopervision International Holding Company, Lp | Wettable silicone hydrogel contact lenses and related compositions and methods |
US8231218B2 (en) | 2006-06-15 | 2012-07-31 | Coopervision International Holding Company, Lp | Wettable silicone hydrogel contact lenses and related compositions and methods |
GB2493017B (en) * | 2011-07-19 | 2016-08-03 | Carl Zeiss Meditec Sas | Cassette for an intraocular lens and injector device for an intraocular lens |
CN102502091A (zh) * | 2011-10-27 | 2012-06-20 | 广州科甫眼镜有限公司 | 具有放大作用的透明接触镜贮存和摆放器具及其制备方法 |
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- 2003-12-09 AU AU2003296355A patent/AU2003296355B2/en not_active Ceased
- 2003-12-09 CN CNB2003801074017A patent/CN100384484C/zh not_active Expired - Fee Related
- 2003-12-09 EP EP20100181092 patent/EP2281584A1/fr not_active Withdrawn
- 2003-12-09 CA CA2510567A patent/CA2510567C/fr not_active Expired - Fee Related
- 2003-12-09 EP EP20100181172 patent/EP2281586A1/fr not_active Withdrawn
- 2003-12-09 EP EP20100181163 patent/EP2283879A1/fr not_active Withdrawn
- 2003-12-09 BR BRPI0317631-2B1A patent/BR0317631B1/pt not_active IP Right Cessation
- 2003-12-09 CA CA 2737309 patent/CA2737309A1/fr not_active Abandoned
- 2003-12-09 KR KR1020057011801A patent/KR101229813B1/ko active IP Right Grant
- 2003-12-09 WO PCT/US2003/039017 patent/WO2004060099A2/fr active Application Filing
- 2003-12-09 EP EP10181065.3A patent/EP2281583B1/fr not_active Expired - Fee Related
- 2003-12-09 EP EP03814670A patent/EP1575625B1/fr not_active Revoked
- 2003-12-09 EP EP10181154.5A patent/EP2283878B1/fr not_active Expired - Fee Related
- 2003-12-09 EP EP20100181146 patent/EP2281585A1/fr not_active Withdrawn
- 2003-12-09 DE DE60331170T patent/DE60331170D1/de not_active Expired - Lifetime
- 2003-12-09 CA CA2809146A patent/CA2809146C/fr not_active Expired - Fee Related
- 2003-12-09 US US10/731,258 patent/US20050006255A1/en not_active Abandoned
- 2003-12-09 EP EP10181121.4A patent/EP2283877B1/fr not_active Expired - Fee Related
- 2003-12-22 TW TW092136345A patent/TWI350187B/zh not_active IP Right Cessation
- 2003-12-23 AR ARP030104826 patent/AR043320A1/es not_active Application Discontinuation
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2006
- 2006-01-10 HK HK06100398.2A patent/HK1080399A1/xx not_active IP Right Cessation
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2008
- 2008-12-23 US US12/342,506 patent/US20090165427A1/en not_active Abandoned
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2010
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2011
- 2011-06-29 HK HK11106692.5A patent/HK1152663A1/xx not_active IP Right Cessation
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