US20040258765A1 - Method for treatment of sores and lesions of the skin - Google Patents
Method for treatment of sores and lesions of the skin Download PDFInfo
- Publication number
- US20040258765A1 US20040258765A1 US10/602,404 US60240403A US2004258765A1 US 20040258765 A1 US20040258765 A1 US 20040258765A1 US 60240403 A US60240403 A US 60240403A US 2004258765 A1 US2004258765 A1 US 2004258765A1
- Authority
- US
- United States
- Prior art keywords
- composition
- honey
- bee
- caffeine
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Definitions
- the present invention relates generally to methods for treatment of sores and skin lesions and, more particularly, to methods for treating sores and lesions associated with Herpes Simplex Virus.
- Herpes Simplex Virus is a common cause of infections of the skin and mucus membranes. HSV is one of the most difficult viruses to control and has plagued civilization for thousands of years. HSV infection is typically manifested by painful, blister-like lesions or sores on the mouth or face (oral herpes) or in the genital area (genital herpes). While rarely fatal, herpes sores can be quite painful and unsightly and may cause embarrassment to the infected person.
- HSV-1 and HSV-2 are very similar. They can occur separately or can infect the same individual. HSV-1 is generally associated with oral herpes and HSV-2 is generally associated with genital herpes. It is now known, however, that HSV-2 can cause oral herpes and HSV-1 can cause genital herpes.
- HSV enters the body through the skin or mucus membranes following contact with an infected person.
- the virus penetrates vulnerable cells in the lower layers of the skin and attempts to replicate itself in the cell nuclei.
- HSV never causes symptoms to occur.
- HSV's replication process destroys the host cells, symptoms in the form of sores, ulcers, and fluid-filled blisters may appear.
- the sores from the primary infection eventually heal without scarring.
- the virus that caused the infection remains in the body and migrates through branches of nerve cells to clusters at the nerve cell ends called the ganglia.
- the virus persists in the ganglia in a latent state, during which viral replication does not occur. While the virus is latent, symptoms of the virus do not appear.
- Recurrent infections of HSV tend to be milder than primary infections and can be set off by a variety of factors, including illness and stress. For some persons infected with herpes virus, recurrent infections may be frequent. Approximately 20% to 40% of persons with HSV-1 experience recurrent outbreaks. For persons infected with HSV-2, the recurrence rate is up to 80%.
- the present invention comprises a pharmaceutical composition for topical application to treat sores, ulcers, lesions, or other disorders of the skin.
- the composition has been found to be effective for treatment of sores associated with Herpes Simplex Virus.
- the composition may also be useful for treatment of chicken pox, shingles, or other skin disorders resulting from viral infections.
- the active ingredients of the composition comprise a combination of a bee product and caffeine.
- the bee product may, for example, comprise honey, bee propolis, bee pollen, or royal jelly.
- Variations of the composition may also include tannin as an active ingredient.
- the composition may be in the form of a cream, ointment, or gell that is applied topically to the skin.
- the composition may also be used in other forms, such as a spray, shampoo, soap, lipstick, or adhesive bandage.
- the invention may also be useful as a health beverage.
- the present invention comprises compositions for topical application to the skin including as active ingredients a combination of a bee product and caffeine.
- the bee product may, for example, comprise honey, bee propolis, bee pollen, or royal jelly.
- compositions according to the present invention may be formed with active ingredients extracted from honey or other bee products, or with active ingredients synthesized to resemble the active ingredients in honey or bee products.
- the term bee product as used herein includes active ingredients extracted from bee products and active ingredients synthesized to resemble the active ingredients in bee products.
- Variations of the composition may also include a tannin as an active ingredient.
- a salve was prepared comprising a mixture of honey (preferably raw) and coffee grounds.
- the salve was prepared by combining approximately one tablespoon of coffee grounds with enough honey to hold the grounds together. It is estimated that the salve comprised approximately 15% by weight of honey.
- the salve was applied to sores of one patient caused by type I herpes simplex virus by spreading the salve over the sores and covering the sores with a bandage. Following application of the salve to the sores, the sores were reduced significantly in size within 3 to 4 hours and the sores were completely healed within 2 days. Prior to treatment with the anti-HSV composition, the patient experienced recurring infections once or twice a month. Following treatment, the patient has not had a single recurrence of the infection after more than five months.
- compositions according to the present invention may be made using micronized caffeine particles as described in U.S. Pat. No. 5,382,436, which is incorporated herein by reference. Further studies are needed in order to determine the amount of caffeine and bee product that is most efficacious. At present, the inventor believes that compositions containing greater than 1% by weight of caffeine would be effective.
- the composition may include, in addition to the active agents, a pharmaceutically acceptable excipient.
- Additives such as oils, thickening agents and emulsifiers may be used to form an ointment, cream, lotion or gel that is more suitable for topical application.
- natural oils include corn oil, almond oil, olive oil, coconut oil, caster oil, and lanolin oil.
- Synthetic oils, such as silicone oil may also be used.
- Possible thickening agents include natural waxes such as beeswax, paraffin waxes, and hydrocarbon polymers.
- U.S. Pat. No. 6,171,604 which is incorporated herein by reference, describes various honey-based preparations for topical application. Preparations described in this patent may be used with the present invention.
- the composition may be formed into an ointment, cream, salve, lotion, or gel that is applied topically to the skin.
- the composition may also be used in other forms, such as a spray, shampoo, soap, or lipstick.
- Another use of the present invention is in adhesive bandages having an absorbent pad that can be applied to the skin. Mixtures of caffeine and honey may also have use in health beverages that can be ingested. Beverages may be used to prevent outbreaks of HSV or other illnesses, or may be ingested to lessen the effect of an outbreak.
- CAPE suppresses the growth of cancerous cells and may, therefore, act as an anti-tumor agent.
- propolis has been shown to inhibit the growth of some viruses including herpes and influenza. Tannins are naturally occurring plant polyphenols which combine with protein and other polymers to form stable compounds. Some tannins are known to have antiseptic, antibiotic and antiviral properties. Tannins at relatively high concentrations can inhibit the activity of enzymes. Some tannins also show strong antitumor activity.
- Combined therapies have become increasingly popular in combating HSV and research has shown that certain drugs may enhance the effect of other drugs to produce not only an additive but also a synergistic effect.
- Combined therapies known to be effective for treatment of herpes include trifluorothymidine (TFT) with interferon-alpha, caffeine with interferon, and dimethyl sulfoxide (DMSO) with idoxuridine (IDU). It is suspected that the combination of a bee product and caffeine produces such a synergistic effect that inhibits replication of the virus more so than would treatment with either caffeine or bee product alone. Tannin may also play a role in retaining the active ingredients in honey and caffeine in the lower layers of the skin to prevent recurrence of HSV.
- composition is useful for the treatment of sores and lesions caused by herpes simplex virus, and may also be useful for the treatment of chicken pox, shingles or other viral infections.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Insects & Arthropods (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/602,404 US20040258765A1 (en) | 2003-06-23 | 2003-06-23 | Method for treatment of sores and lesions of the skin |
PCT/US2004/019892 WO2005000032A1 (en) | 2003-06-23 | 2004-06-22 | Method for treatment of sores and lesions of the skin |
AU2004251720A AU2004251720B2 (en) | 2003-06-23 | 2004-06-22 | Method for treatment of sores and lesions of the skin |
CA2533591A CA2533591C (en) | 2003-06-23 | 2004-06-22 | Method for treatment of sores and lesions of the skin |
CNA2004800242467A CN1838885A (zh) | 2003-06-23 | 2004-06-22 | 治疗皮肤的疮和损害的方法 |
EP04755805A EP1643846A4 (en) | 2003-06-23 | 2004-06-22 | METHOD FOR THE TREATMENT OF WOUNDS AND LESIONS OF THE SKIN |
US14/845,580 US9387227B2 (en) | 2003-06-23 | 2015-09-04 | Method for treatment of sores and lesions of the skin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/602,404 US20040258765A1 (en) | 2003-06-23 | 2003-06-23 | Method for treatment of sores and lesions of the skin |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/845,580 Continuation US9387227B2 (en) | 2003-06-23 | 2015-09-04 | Method for treatment of sores and lesions of the skin |
Publications (1)
Publication Number | Publication Date |
---|---|
US20040258765A1 true US20040258765A1 (en) | 2004-12-23 |
Family
ID=33518088
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/602,404 Abandoned US20040258765A1 (en) | 2003-06-23 | 2003-06-23 | Method for treatment of sores and lesions of the skin |
US14/845,580 Expired - Lifetime US9387227B2 (en) | 2003-06-23 | 2015-09-04 | Method for treatment of sores and lesions of the skin |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/845,580 Expired - Lifetime US9387227B2 (en) | 2003-06-23 | 2015-09-04 | Method for treatment of sores and lesions of the skin |
Country Status (6)
Country | Link |
---|---|
US (2) | US20040258765A1 (zh) |
EP (1) | EP1643846A4 (zh) |
CN (1) | CN1838885A (zh) |
AU (1) | AU2004251720B2 (zh) |
CA (1) | CA2533591C (zh) |
WO (1) | WO2005000032A1 (zh) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007021189A2 (en) * | 2005-08-15 | 2007-02-22 | Provimi Holding B.V. | Method of treating parturient placental mammals in order to reduce maternal and/or utirine exhaustion |
US20070098671A1 (en) * | 2005-11-02 | 2007-05-03 | Martin Gregory D | Composition and method of treatment for irritated skin |
US20080167277A1 (en) * | 2006-12-29 | 2008-07-10 | Charles Conrad | Methods of treating skin disorders with caffeic acid analogs |
US20090226483A1 (en) * | 2008-03-10 | 2009-09-10 | Zdenko Glavas | Super brown cream |
US20100074964A1 (en) * | 2008-03-10 | 2010-03-25 | Zdenko Glavas | Super brown cream |
US20100129462A1 (en) * | 2007-04-16 | 2010-05-27 | Kikuji Yamaguchi | Decolonizing agent for helicobacter pylori |
US20100152143A1 (en) * | 2008-09-30 | 2010-06-17 | Moleculin, Llc | Methods of Treating Skin Disorders with Caffeic Acid Analogs |
GB2471504A (en) * | 2009-07-02 | 2011-01-05 | Paul Myott | Caffeine for use in the healing of damaged skin, body tissue, muscles, organs and hair |
US7893070B2 (en) | 2005-08-15 | 2011-02-22 | Provimi Holding B.V. | Method of treating parturient placental mammals in order to reduce maternal and/or uterine exhaustion |
US20110142957A1 (en) * | 2005-08-15 | 2011-06-16 | Van Kempen Theo | Method of treating parturient placental mammals in order to reduce maternal and/or uterine exhaustion |
US8109981B2 (en) | 2005-01-25 | 2012-02-07 | Valam Corporation | Optical therapies and devices |
CN103083424A (zh) * | 2013-01-21 | 2013-05-08 | 徐雪云 | 一种治疗小儿疱疹性口炎的中药制剂 |
US9254354B2 (en) | 2009-11-17 | 2016-02-09 | Brightwake Limited | Device and method for processing fluid |
CN107496636A (zh) * | 2017-10-21 | 2017-12-22 | 马有奎 | 治疗带状疱疹的中药组合物及其制备方法 |
US9877991B2 (en) | 2013-08-12 | 2018-01-30 | Decima Health Limited | Reaction platform and method for making pollen based materials in combination with beeswax and uses thereof |
US10232048B1 (en) | 2014-11-18 | 2019-03-19 | Divine Api-Logics, LLC | Apitherapy method and composition |
US10434123B2 (en) | 2013-08-12 | 2019-10-08 | Decima Health Limited | Reaction platform and method for making pollen based materials and uses thereof |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MD3939C2 (ro) * | 2009-01-28 | 2010-04-30 | Виктор УСАТЕНКО | Unguent antimicrobian pe bază de produse apicole (variante) |
AU2014353853A1 (en) * | 2013-11-25 | 2016-07-07 | Biomedical Concepts Llc | Composition, system and method for treating skin |
GR1009175B (el) | 2016-06-13 | 2017-12-18 | Apivita Καλλυντικα Διαιτητικα Φαρμακα Ανωνυμη Εμπορικη Και Βιοτεχνικη Εταιρεια | Συνδυασμος εκχυλισματος μικροφυκους nannochloropsis gaditana και εκχυλισματος προπολης ως δραστικου συστατικου σε καλλυντικοτεχνικες φορμουλες για δερματικη χρηση |
Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4285934A (en) * | 1979-07-13 | 1981-08-25 | Tinnell James E | Treatment for herpes virus |
US4382886A (en) * | 1981-04-13 | 1983-05-10 | Sosnowski Zenon M | Method for extracting propolis and water soluble dry propolis powder |
US5382436A (en) * | 1989-11-24 | 1995-01-17 | Surtech International Limited | Caffeine in the treatment of Herpes simplex virus infections |
US5620724A (en) * | 1993-07-26 | 1997-04-15 | Adler; Richard S. | Drink container with holder for used concentrate packet |
US5667791A (en) * | 1996-05-31 | 1997-09-16 | Thione International, Inc. | X-ray induced skin damage protective composition |
US5952373A (en) * | 1994-12-13 | 1999-09-14 | Beiersdorf Ag | Agents acting against hyperreactive and hypoactive, deficient skin conditions and manifest dermatitides |
US5980875A (en) * | 1996-04-12 | 1999-11-09 | Mousa; Mahmoud A. | Honey preparations |
US6171604B1 (en) * | 1996-04-12 | 2001-01-09 | Mahmoud A. Mousa | Honey preparations |
US6190680B1 (en) * | 1998-04-01 | 2001-02-20 | The Nisshin Oil Mills, Ltd. | Oily composition and process for producing the same |
US6342239B1 (en) * | 1998-01-13 | 2002-01-29 | KOSéCORPORATION | Powder composition, a powder dispersion in oil and a cosmetic composition containing said powder composition and a powder dispersion in oil |
US6524625B2 (en) * | 1998-06-30 | 2003-02-25 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyuto | Physiologically active extract obtained from indigo plant polygonum tinctorium |
US20030086986A1 (en) * | 1998-08-06 | 2003-05-08 | Bruijn Chris De | Ophthalmic, pharmaceutical and other healthcare preparations with naturally occurring plant compounds, extracts and derivatives |
US6953574B2 (en) * | 2002-06-21 | 2005-10-11 | Technology Commercialization, Inc. | Method for producing a fermented hydrolyzed medium containing microorganisms |
US7288265B1 (en) * | 2000-10-16 | 2007-10-30 | Lectec Corporation | Treating viral infection at smallpox vaccination site |
US7396546B2 (en) * | 2001-08-06 | 2008-07-08 | The Quigley Corporation | Anti-microbial compositions and methods of using same |
-
2003
- 2003-06-23 US US10/602,404 patent/US20040258765A1/en not_active Abandoned
-
2004
- 2004-06-22 AU AU2004251720A patent/AU2004251720B2/en not_active Ceased
- 2004-06-22 EP EP04755805A patent/EP1643846A4/en not_active Ceased
- 2004-06-22 CN CNA2004800242467A patent/CN1838885A/zh active Pending
- 2004-06-22 CA CA2533591A patent/CA2533591C/en not_active Expired - Fee Related
- 2004-06-22 WO PCT/US2004/019892 patent/WO2005000032A1/en active Search and Examination
-
2015
- 2015-09-04 US US14/845,580 patent/US9387227B2/en not_active Expired - Lifetime
Patent Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4285934A (en) * | 1979-07-13 | 1981-08-25 | Tinnell James E | Treatment for herpes virus |
US4382886A (en) * | 1981-04-13 | 1983-05-10 | Sosnowski Zenon M | Method for extracting propolis and water soluble dry propolis powder |
US5382436A (en) * | 1989-11-24 | 1995-01-17 | Surtech International Limited | Caffeine in the treatment of Herpes simplex virus infections |
US5620724A (en) * | 1993-07-26 | 1997-04-15 | Adler; Richard S. | Drink container with holder for used concentrate packet |
US5952373A (en) * | 1994-12-13 | 1999-09-14 | Beiersdorf Ag | Agents acting against hyperreactive and hypoactive, deficient skin conditions and manifest dermatitides |
US5980875A (en) * | 1996-04-12 | 1999-11-09 | Mousa; Mahmoud A. | Honey preparations |
US6171604B1 (en) * | 1996-04-12 | 2001-01-09 | Mahmoud A. Mousa | Honey preparations |
US5667791A (en) * | 1996-05-31 | 1997-09-16 | Thione International, Inc. | X-ray induced skin damage protective composition |
US6342239B1 (en) * | 1998-01-13 | 2002-01-29 | KOSéCORPORATION | Powder composition, a powder dispersion in oil and a cosmetic composition containing said powder composition and a powder dispersion in oil |
US6190680B1 (en) * | 1998-04-01 | 2001-02-20 | The Nisshin Oil Mills, Ltd. | Oily composition and process for producing the same |
US6524625B2 (en) * | 1998-06-30 | 2003-02-25 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyuto | Physiologically active extract obtained from indigo plant polygonum tinctorium |
US20030086986A1 (en) * | 1998-08-06 | 2003-05-08 | Bruijn Chris De | Ophthalmic, pharmaceutical and other healthcare preparations with naturally occurring plant compounds, extracts and derivatives |
US7288265B1 (en) * | 2000-10-16 | 2007-10-30 | Lectec Corporation | Treating viral infection at smallpox vaccination site |
US7396546B2 (en) * | 2001-08-06 | 2008-07-08 | The Quigley Corporation | Anti-microbial compositions and methods of using same |
US6953574B2 (en) * | 2002-06-21 | 2005-10-11 | Technology Commercialization, Inc. | Method for producing a fermented hydrolyzed medium containing microorganisms |
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8109981B2 (en) | 2005-01-25 | 2012-02-07 | Valam Corporation | Optical therapies and devices |
US7893070B2 (en) | 2005-08-15 | 2011-02-22 | Provimi Holding B.V. | Method of treating parturient placental mammals in order to reduce maternal and/or uterine exhaustion |
WO2007021189A3 (en) * | 2005-08-15 | 2007-04-19 | Provimi Holding B V | Method of treating parturient placental mammals in order to reduce maternal and/or utirine exhaustion |
WO2007021189A2 (en) * | 2005-08-15 | 2007-02-22 | Provimi Holding B.V. | Method of treating parturient placental mammals in order to reduce maternal and/or utirine exhaustion |
US20110142957A1 (en) * | 2005-08-15 | 2011-06-16 | Van Kempen Theo | Method of treating parturient placental mammals in order to reduce maternal and/or uterine exhaustion |
US20070098671A1 (en) * | 2005-11-02 | 2007-05-03 | Martin Gregory D | Composition and method of treatment for irritated skin |
US20080167277A1 (en) * | 2006-12-29 | 2008-07-10 | Charles Conrad | Methods of treating skin disorders with caffeic acid analogs |
US8241683B2 (en) * | 2007-04-16 | 2012-08-14 | Kikuji Yamaguchi | Decolonizing agent for helicobacter pylori |
US20100129462A1 (en) * | 2007-04-16 | 2010-05-27 | Kikuji Yamaguchi | Decolonizing agent for helicobacter pylori |
US20100074964A1 (en) * | 2008-03-10 | 2010-03-25 | Zdenko Glavas | Super brown cream |
US20090226483A1 (en) * | 2008-03-10 | 2009-09-10 | Zdenko Glavas | Super brown cream |
US20100152143A1 (en) * | 2008-09-30 | 2010-06-17 | Moleculin, Llc | Methods of Treating Skin Disorders with Caffeic Acid Analogs |
US8450337B2 (en) | 2008-09-30 | 2013-05-28 | Moleculin, Llc | Methods of treating skin disorders with caffeic acid analogs |
GB2471504A (en) * | 2009-07-02 | 2011-01-05 | Paul Myott | Caffeine for use in the healing of damaged skin, body tissue, muscles, organs and hair |
US9254354B2 (en) | 2009-11-17 | 2016-02-09 | Brightwake Limited | Device and method for processing fluid |
CN103083424A (zh) * | 2013-01-21 | 2013-05-08 | 徐雪云 | 一种治疗小儿疱疹性口炎的中药制剂 |
US9877991B2 (en) | 2013-08-12 | 2018-01-30 | Decima Health Limited | Reaction platform and method for making pollen based materials in combination with beeswax and uses thereof |
US10434123B2 (en) | 2013-08-12 | 2019-10-08 | Decima Health Limited | Reaction platform and method for making pollen based materials and uses thereof |
US10987384B2 (en) | 2013-08-12 | 2021-04-27 | Decima Health Limited | Reaction platform and method for making pollen based materials and uses thereof |
US10232048B1 (en) | 2014-11-18 | 2019-03-19 | Divine Api-Logics, LLC | Apitherapy method and composition |
CN107496636A (zh) * | 2017-10-21 | 2017-12-22 | 马有奎 | 治疗带状疱疹的中药组合物及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
US9387227B2 (en) | 2016-07-12 |
WO2005000032A1 (en) | 2005-01-06 |
AU2004251720B2 (en) | 2009-01-08 |
AU2004251720A1 (en) | 2005-01-06 |
CA2533591A1 (en) | 2005-01-06 |
US20150374759A1 (en) | 2015-12-31 |
EP1643846A4 (en) | 2009-06-24 |
CN1838885A (zh) | 2006-09-27 |
CA2533591C (en) | 2012-11-06 |
EP1643846A1 (en) | 2006-04-12 |
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