US20040209226A1 - Single-stage implant system - Google Patents
Single-stage implant system Download PDFInfo
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- US20040209226A1 US20040209226A1 US10/837,801 US83780104A US2004209226A1 US 20040209226 A1 US20040209226 A1 US 20040209226A1 US 83780104 A US83780104 A US 83780104A US 2004209226 A1 US2004209226 A1 US 2004209226A1
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- abutment
- implant
- coping
- rim
- flowable material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/008—Healing caps or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C13/00—Dental prostheses; Making same
- A61C13/0001—In-situ dentures; Trial or temporary dentures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0001—Impression means for implants, e.g. impression coping
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0048—Connecting the upper structure to the implant, e.g. bridging bars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0048—Connecting the upper structure to the implant, e.g. bridging bars
- A61C8/005—Connecting devices for joining an upper structure with an implant member, e.g. spacers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0048—Connecting the upper structure to the implant, e.g. bridging bars
- A61C8/005—Connecting devices for joining an upper structure with an implant member, e.g. spacers
- A61C8/0065—Connecting devices for joining an upper structure with an implant member, e.g. spacers with expandable or compressible means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0048—Connecting the upper structure to the implant, e.g. bridging bars
- A61C8/005—Connecting devices for joining an upper structure with an implant member, e.g. spacers
- A61C8/0066—Connecting devices for joining an upper structure with an implant member, e.g. spacers with positioning means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0048—Connecting the upper structure to the implant, e.g. bridging bars
- A61C8/005—Connecting devices for joining an upper structure with an implant member, e.g. spacers
- A61C8/0069—Connecting devices for joining an upper structure with an implant member, e.g. spacers tapered or conical connection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0089—Implanting tools or instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
- A61C8/0033—Expandable implants; Implants with extendable elements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
- A61C8/0037—Details of the shape
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0048—Connecting the upper structure to the implant, e.g. bridging bars
- A61C8/005—Connecting devices for joining an upper structure with an implant member, e.g. spacers
- A61C8/0054—Connecting devices for joining an upper structure with an implant member, e.g. spacers having a cylindrical implant connecting part
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0048—Connecting the upper structure to the implant, e.g. bridging bars
- A61C8/005—Connecting devices for joining an upper structure with an implant member, e.g. spacers
- A61C8/0057—Connecting devices for joining an upper structure with an implant member, e.g. spacers with elastic means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0048—Connecting the upper structure to the implant, e.g. bridging bars
- A61C8/005—Connecting devices for joining an upper structure with an implant member, e.g. spacers
- A61C8/0059—Connecting devices for joining an upper structure with an implant member, e.g. spacers with additional friction enhancing means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0048—Connecting the upper structure to the implant, e.g. bridging bars
- A61C8/005—Connecting devices for joining an upper structure with an implant member, e.g. spacers
- A61C8/006—Connecting devices for joining an upper structure with an implant member, e.g. spacers with polygonal positional means, e.g. hexagonal or octagonal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0048—Connecting the upper structure to the implant, e.g. bridging bars
- A61C8/005—Connecting devices for joining an upper structure with an implant member, e.g. spacers
- A61C8/0069—Connecting devices for joining an upper structure with an implant member, e.g. spacers tapered or conical connection
- A61C8/0071—Connecting devices for joining an upper structure with an implant member, e.g. spacers tapered or conical connection with a self-locking taper, e.g. morse taper
Abstract
Description
- The invention relates generally to implants and, in particular, a single-stage dental implant that promotes healing of the gingiva and osseointegration simultaneously.
- It is becoming more common to replace a missing tooth with a prosthetic tooth that is placed upon and attached to a dental implant. The dental implant serves as the artificial root in that it integrates with the jawbone. The prosthetic tooth preferably has a size and a color that mimics the missing natural tooth. Consequently, the patient has an aesthetically pleasing and structurally sound artificial tooth.
- Current methods by which the prosthetic tooth and implant are completely integrated into the patient's mouth require six to ten months, and sometimes longer, because two distinct, time-consuming steps are involved. First, the implant is inserted into the jawbone and covered by suturing the overlying gingival tissue. Covering the implant with the overlying gingiva is needed to minimize the likelihood of infection around the implant. Covering the implant also helps to guard against any disturbances of the implant that may slow its rate of osseointegration. The implant then osseointegrates with the jawbone for a period, usually in the range of three to six months.
- After osseointegration is complete, the second step is encountered in which the gingiva is again cut open and a healing abutment is placed onto the implant. The overlying gingiva is sutured to allow it to properly heal around the healing abutment. Thus, when the prosthetic tooth is eventually placed upon the implant, the gingiva nicely conforms around the prosthetic tooth. However, it typically takes four to eight weeks before the gingiva is healed and the prosthetic tooth can be placed on the implant to complete the overall process. These implants can be referred to as “subgingival implants.”
- Single-stage implants or “transgingival implants” simultaneously promote osseointegration and the healing of the gingiva. This is accomplished by providing an implant that has a portion that integrates with the jawbone and a portion that extends through the overlying gingiva so that the gingiva properly heals therearound. Thus, the four to eight week gingival healing process occurs during the three to six month period of osseointegration. Consequently, the patient is fitted with a prosthesis in a shorter period of time. And, the gingiva is lacerated and sutured one less time compared with two-stage systems which reduces the trauma to that region, the discomfort experienced by the patient, and the overall cost because the number of dental procedures is minimized.
- It is sometimes desirable to convert a subgingival implant to the configuration of a transgingival style or vice versa. For example, if one style is best suited for installation in a first site in a patient's jawbone, but another style is best suited for installation in another site, the restoring dentist seeking to fashion a bridge supported on implants installed in both sites might prefer to convert one style to the other in order to make the bridge using common components. Similarly, if a restoring dentist has on hand implants of one style and components for a new improved style become available, for reasons of economy it might be desirable to convert the available implants to the new styles so they can be used with the new components. However, known transition components introduce gaps between the components and present alignment problems for the restoration components.
- Furthermore, during the preparation of dental restorations supported on artificial roots implanted in living jawbone, it is frequently useful to provide a temporary cover for a post or abutment (that eventually holds the artificial dentition) supported on a transgingival implant. It is also desirable to prevent the gingival tissue from collapsing around the transgingival implant or to maintain an opening in the tissue at least until temporary dentition is made. This invention also relates to a temporary cap useful to cover such abutments and posts for a transgingival implant.
- The single-stage dental implant is typically installed through a ridge in the jawbone that is covered by gingival tissue. The dental implant provides an artificial root on which a prosthetic tooth is mounted to replace a missing tooth which formerly emerged from the jawbone. The single-stage implant comprises an anchoring portion for extending into and integrating with the jawbone and an integral gingival section that extends beyond the ridge of the jawbone. Because the gingival section is integral with the anchoring portion, there is no seam in which bacteria may collect to cause infections.
- The implant has various embodiments with various internal structures which allow the implant to be driven into the bone tissue in the patient's mouth. These internal structures typically engage a carrier that is delivered with the implant. Thus, the clinician uses tools that engage the carrier to drive the implant to the appropriate depth. After insertion, the clinician removes the carrier from the implant and a cover screw is placed thereover. The implant also has structural features enhancing its ability to support the artificial dentition on the post.
- The inventive single-stage system also includes conversion components that allow a subgingival implant to have the same contour and structure as a transgingival implant. To convert a subgingival implant, a tubular member having an outer counter the same as the gingival head section of the transgingival implant is non-rotationally attached to the hexagonal fitting on the upper end of the subgingival implant. The fastener holding the tubular member on the implant extends above the tubular component and usually contains a non-rotational fitting (e.g. a hexagon). To convert the transgingival implant, a single transition component is threaded into the bore of the transgingival implant. The upper part of the transition component has the same contour as the portion of the fastener (used with the tubular member) extending above the tubular member. Thus, these conversion components provide a precise configuration that is present on both a converted transgingival implant and a converted subgingival implant which allows both to use the same restoration components.
- The inventive single-stage implant system further contemplates novel components to mate with the posts of the implants. The posts and abutments (hereinafter “posts” for convenience) on which artificial teeth are mounted generally extend supragingivally from a base at or beneath the gum surface to an end that may be narrower than the base. One inventive cap is hollow and open at least at its lower end so as to envelop the post in a generally telescopic manner when placed over the post. The end of the cap facing the base of the post is fitted with a rim enclosing an annular hollow space so as to snap over the periphery of the base when the cap encloses the post. When so fitted over the post, the cap covers the post and prevents the gum tissue from collapsing around the base of the post and top of the implant. It may also maintain an opening through the gum tissue for use by the restored tooth that is eventually mounted on the post. If it is desired for the cap to function as a temporary tooth, a suitable temporary cement can be used to fill the space between the cap and the post, in which event the hole in the top of the cap will serve as a vent for excess cement.
- In another embodiment of the invention, the cap is open at its top and has perforations through its sides. When this embodiment is fitted over the post and covered with a tooth-shaped shell filled with a suitable dental plastic material that can be forced through the perforations into contact with the post and allowed to harden in a short time, a temporary tooth in the shape of the shell can be fashioned at chairside in the mouth of a patient, or on a model of the patient's case out of the patient's mouth. When the plastic material hardens, the shell can be removed, and this tooth can be cemented to the post to function as a temporary tooth which is cosmetically similar to adjacent teeth.
- The above summary of the present invention is not intended to represent each embodiment, or every aspect, of the present invention. This is the purpose of the figures and the detailed description which follow.
- In the accompanying drawings:
- FIGS. 1a-1 c are side, insertion end, and gingival end views of an implant according to the present invention;
- FIGS. 2a-2 c are side, insertion end, and gingival end views of an implant;
- FIGS. 3 and 4 are side views of an implant with a roughened outer surface;
- FIGS. 5a-5 c are side, insertion end, and gingival end views of a wide-diameter implant;
- FIGS. 6a-6 d are side, section, head end, and insertion end views of a cover screw;
- FIGS. 7a-7 d are side, section, head end, and insertion end views of a cover screw;
- FIGS. 8a-8 c are side, head-end, and insertion-end views of a cover screw;
- FIGS. 9a-9 d are a side view, supragingival end view, insertion end view, and an assembly view of an abutment post for supporting a dental prosthesis;
- FIGS.10 is a side view of a gingival end of an implant with a carrier attached thereto;
- FIGS. 11a-11 c are side, insertion end, and gingival end views of an implant;
- FIGS.12 is an enlarged view of the gingival end of FIG. 11;
- FIGS. 13a-13 c are side, longitudinal section, and top end views of a mount body;
- FIGS. 14a-14 b are a mount screw and a head-end view for use with the mount body of FIG. 13;
- FIG. 15 is an exploded side elevation, partially in section, view of a transition component and associated components for use with a transgingival-style dental implant;
- FIG. 16 shows the components of FIG. 15 assembled;
- FIG. 17 is an exploded side elevation, partially in section, of a transition component and associated components for use with a subgingival-style implant;
- FIG. 18 shows the components of FIG. 17 assembled.
- FIG. 19 is a longitudinal section taken through the middle of a cap embodying the invention;
- FIG. 20 is a bottom plan view of the cap of FIG. 19;
- FIG. 21 is an enlarged view of the lower right-hand corner of the cap of FIG. 19;
- FIGS. 22a-22 c are a side elevation, a top perspective, and a bottom perspective view of a modified cap embodying the invention;
- FIGS. 23a-23 c are a vertical section, a top perspective, and a bottom perspective view taken through the middle of the cap of FIG. 22;
- FIG. 24 is a side elevation, partially in section, of an implant system using the cap of FIGS. 22 and 23; and
- FIG. 25 is the same sectional view of the cap as in FIG. 23 with the addition of a diagrammatic illustration of an artificial tooth shell around the cap.
- FIGS. 1a-1 c illustrate an
implant 10 having amain body 12 with a threadedouter surface 13. The threadedouter surface 13 includes a self-tapping region withincremental cutting edges 14 at anapical end 16 of themain body 12. Theseincremental cutting edges 14 are defined in detail in U.S. Pat. No. 5,727,943, entitled “Self-Tapping, Screw-Type Dental Implant” which is herein incorporated by reference in its entirety. - An
axial opening 18 in agingival end 20 of themain body 12 has three distinct zones proceeding from the uppermost edge of thegingival end 20 into the interior of theimplant 10. An inwardly-taperingzone 22 is followed by a substantiallycylindrical zone 24 which, in turn, is followed by an internally-threadedzone 26. - An
outer surface 28 tapers downwardly from the uppermost edge of thegingival end 20 to amaximum diameter region 30. On theouter surface 28 between the uppermost edge of theimplant 10 and themaximum diameter region 30 is a set offlat surfaces 32 shown here in a commonly-used hexagonal configuration. This set offlat surfaces 32 can be engageable with a tool that screws theimplant 10 into the bone tissue. Alternatively, the set offlat surfaces 32 may be engaged by a carrier that is delivered with theimplant 10 such that the clinician applies torque to the carrier which then is transferred into the implant 10 (see FIG. 10). Thedistance 34 between two parallelflat surfaces 32 can be made larger than the major diameter of the threads defining the threadedouter surface 13 of themain body 12 of theimplant 10. - With regard to the details of the structure in the
gingival end 20, each of the threezones opening 18 has a unique function. Each function is useful in connection with several different components of the system. These components will be discussed with reference to FIGS. 6-10. - FIGS. 2a-2 c disclose an
implant 36 that differs from theimplant 10 of FIG. 1 in the details of cuttingedges 14′ and the contours of the threads defining the threadedouter surface 13′. When viewed in cross-section, the threadedouter surface 13′ is non-circular in the region of the threads and/or the troughs between the threads. This type of thread structure is defined in detail in U.S. application Ser. No. 08/82,056, filed Jan. 13, 1997, entitled “Reduced Friction, Screw-Type Dental Implant” which is herein incorporated by reference in its entirety. However, thezones opening 18 and the structure at thegingival end 20 are the same in theimplant 36 as theimplant 10 of FIGS. 1a-1 c. - In FIG. 3, an
implant 38 has a roughened outer threadedsurface 40. The roughened outer threadedsurface 40 may be produced through grit blasting or acid etching, or a combination of these two procedures. Exemplary processes of grit blasting and acid etching are described in U.S. Pat. Nos. 5,607,480 and 5,603,338 which are herein incorporated by reference in their entirety. The roughened outer threadedsurface 40 enhances the osseointegration process. However, thegingival end 20 has a smooth outer surface such that it will not irritate the soft gingival tissue that contacts thegingival end 20. - In FIG. 4, the
implant 38 of FIG. 3 is illustrated having a roughened outer threadedsurface 40 that extends into thegingival end 20. Thus, atransition line 39 between the roughened outer threadedsurface 40 and the smooth surface at thegingival end 20 is located within thesecond zone 24. The positioning of thetransition line 39 closer to thegingival end 20 may be useful in situations where more of thegingival end 20 is inserted into the bone. - In FIGS. 5a-5 c, an
implant 41 having a wide diameter in the region of its roughed outer threadedsurface 42 is illustrated. The diameter is in the range from about 4.5 mm to about 6.0 mm with the diameter of 5.0 mm being a fairly common dimension for a wide diameter implant. Such animplant 41 is useful to engage one or both cortical bones to provide enhanced stability, especially during the period of time after installation. Thegingival end 20 again is structurally the same as the implants of FIGS. 1-4. - Several types of components are attachable to the implants of FIGS. 1-5. FIGS. 6-8 illustrate various types of cover screw that are inserted into the
implant 10. Referring initially to FIGS. 6a-6 d, acover screw 44 has ahead 46, an externally-threadedinsertion end 48, and acylindrical shaft 50 between thehead 46 and theinsertion end 48. - In use, the
insertion end 48 of thecover screw 44 is threaded into the internally-threadedzone 26 of theopening 18 of theimplant 10. Thecylindrical shaft 50 fits within thecylindrical zone 24 of theopening 18 of the implants in FIGS. 1-5. The mating of thecylindrical zone 24 andcylindrical shaft 50 provide stability during insertion of thecover screw 44 into theopening 18. Thehead 46 has a reentrant under-surface 52 which covers theouter surface 28 and theflat surfaces 32 of the implant when thecover screw 44 is placed on the implant of FIGS. 1-5. Thehead 46 also has abore 54 withflat surfaces 56 for engaging a tool, such as an Allen wrench, that turns thecover screw 44 into the internally-threadedzone 26 of the implant. - FIGS. 7a-7 d illustrates a
cover screw 60 having ahead 62, a threadedinsertion end 64, andcylindrical shaft 66 between thehead 62 and theinsertion end 64. The threadedinsertion end 64 threadably engages the internally threadedzone 26 of the implants of FIGS. 1-5. Thecylindrical shaft 66 resides within thecylindrical zone 24. Thehead 62 includes an undercut 67 that covers theouter surface 28 and theflat surfaces 32 of the implant. Thehead 62 also has abore 68 with a region for engaging a tool that installs thecover screw 60 into the implant. The primary difference between thecover screw 60 and thecover screw 44 of FIG. 6 is that thehead 62 of thecover screw 60 has an increased height such that it would extend further above the gingiva. - In FIGS. 8a-8 c, a
cover screw 70 has ahead 72 with a tapering side-surface 74 for engaging the taperedzone 22 of theopening 18 of the implants of FIGS. 1-5. The upper surface of thehead 72 would be approximately flush with the uppermost edge of thegingival end 20 of the implants. The tapering surfaces of the taperedzone 22 and the side-surface 74 are preferably tapered on the same angle suitably to provide a locking taper (e.g. about 18°) when those surfaces are engaged. Acylindrical shaft 78 is placed between thehead 72 and a threadedinsertion end 79. - The
head 72 has abore 76 with flat surfaces for engaging a wrench that turns the cover screw into the internally-threadedzone 26 of theopening 18. Thecover screw 70 of FIG. 8 may be especially suitable for use with wide-diameter implants (e.g. FIG. 5), where the cover screw design of FIGS. 6 and 7 might be excessively bulky. - In FIGS. 9a-9 d, an
abutment post 80 includes four zones in a longitudinal sequence, namely, asupragingival zone 82, a locking-taper zone 84, a substantiallycylindrical zone 86, and an externally-threadedzone 88. The last-mentioned threezones cover screw 70 of FIG. 8. In use, theabutment post 80 is attached to one of the implants of FIGS. 1-5 by inserting the externally-threadedzone 88 into the internally-threadedzone 26 of theopening 18 and rotating thepost 80 until the taperedzones post 80 into the implant, thecylindrical zones zones supragingival zone 82 has longitudinally-extendinggrooves 89 that are useful for engaging a tool to turn thepost 80 into the implant. Thesegrooves 84 are also helpful to hold a cemented prosthesis against rotation on thepost 80. - To ensure that the tapering surfaces84 and 22 do not resist in providing the required axial tension strain from the engagement of the threaded
portions surface 84 of thepost 80, with gold may provide the necessary friction-reducing means. This type of friction-reducing plating is described in U.S. Provisional Application Serial Nos. 60/059,307 and 60/043,106, filed Sep. 17, 1997 and Apr. 17, 1997, respectively, and entitled “Dental Implant System having Improved Stability” and “Low Insertion Torque Screws for Use With Dental Implants”, respectively, which are herein incorporated by reference in their entirety. Thus, the locking tapers may be lubricated through traditional biocompatible lubricants or metallic molecules which serves as a solid type of lubricant. - As shown in FIG. 9d, when the
post 80 is assembled on an implant, such asimplant 41 of FIG. 5, theflat surfaces 32 are outside thepost 80. Thus, theflat surfaces 32 also serve the function of engaging a prosthesis against rotation on the implant, independent of any engagement between the prosthesis and thepost 80. - As an alternative post configuration, the post may be made of two pieces, a tubular member to mate with the
outer surface 28 and a threaded post that is inserted through the tubular member and holds the tubular member on the implant. Such a two-piece abutment system is disclosed in U.S. Ser. No. 08/729,869, filed Oct. 15, 1996, entitled “Two-Piece Dental Abutment,” which is herein incorporated by reference in its entirety. - In FIG. 10, a carrier for the implants of FIGS. 1-5 includes a
main body 90 that has astructure 92 for engaging a driving tool that provides torque to the combination of the carrier and the implant. Although thatstructure 92 is illustrated on the exterior surfaces of themain body 90, that structure may be located on the interior surface of themain body 90 as well. Themain body 90 includes an extendingportion 94 that has at its lowermost portion a diameter that is narrow enough to be inserted into thecylindrical zone 24 of thegingival end 20 of the implant. - The
main body 90 includes an overlapping region with aninternal surface 95 that fits over theflat surfaces 32 of thegingival end 20. Theinternal surface 95 has the cross-sectional shape of a hexagon to mate with the hexagonal shape of the flat surfaces 32. - Between the overlapping region and the extending
portion 94 is a taperedregion 96 that fits the taperedzone 22 of thegingival end 20. However, the taperedregion 96 does not need to engage the taperedzone 22. Although not shown, the extendingportion 94 and theshank region 96 have an axially extending slot whose function is described below. - The extending
portion 94 and shank portion haveinternal threads 97 that mate withscrew 98 that is inserted into the bore of themain body 90. When thescrew 98 is inserted into theinternal threads 97, the extendingportion 94 expands outwardly so as to become in tight frictional engagement with thecylindrical zone 24 of the implant. This process of affixing the carrier onto the implant is typically performed at the manufacturer's facility such that the carrier and the implant are delivered to the clinician as one unit. When the clinician uses the combination of the carrier and the implant, he or she places theapical end 16 of the implant 10 (see e.g. FIG. 1) into a bore in the jawbone. The clinician then uses a tool that engages thestructure 92 on themain body 90, to turn the implant (with its self-tapping threads) into the bore. When the implant is inserted to the proper depth, the clinician then engages the non-circular bore 99 of thescrew 98 with a tool and removes it from the implant. To ensure that the torque applied to thescrew 98 during its removal does not rotate the entire implant, the direction of the thread of thescrew 98 is chosen such that the applied torque would cause the implant to be further inserted into the bone. However, since the insertion of the implant would require more torque than the torque necessary to remove thescrew 98, the implant remains motionless while thescrew 98 is removed. - The
implant 110 of FIGS. 11a-11 c differ from implants of FIG. 1-5 in that theimplant 110 has acylindrical zone 124 that is fitted with shallowhelical grooves 125 in the surface of the wall defining thecylindrical zone 124. Thus, a portion of this wall defining thecylindrical zone 124 remains intact as it forms the lands betweenadjacent grooves 125. Furthermore, theimplant 110 lacks the flat surfaces on its outer surface that form the hexagon on the gingival end as is shown in the implants of FIGS. 1-5. In other words, theouter surface 128 of theimplant 110 is smooth. However, the remaining structures ofimplant 110 are the same asimplant 10 of FIG. 1 and, thus, those remaining structures are now denoted by a 100-Series reference numeral. - Referring now to FIG. 12, the
cylindrical zone 124 of theopening 118 is shown in detail. Fourgrooves 125 form a multi-lead thread having a relatively large pitch. Thegrooves 125 do not cut deeply into the cylinder wall so that they leave relativelywide lands 127 betweenadjacent grooves 125 thereby preserving the portion of the cylinder wall intact. In one practical embodiment of theimplant 110, the axial length of thecylindrical zone 124 is a little more than 1 mm and the pitch of the threads formed by thegrooves 125 about 1 mm. Thus, a single turn of a screw threadably mating with thegrooves 125 serves to insert or remove that screw from thezone 124. - Even with the structure of the
cylindrical zone 124 of FIGS. 11-12, theimplant 110 can cooperate with the covers screws of FIGS. 6-8, and with theabutment post 80 of FIG. 9. Additionally, it serves functions related to the purposes of the implant mount and screw shown in FIGS. 13 and 14. - The
implant mount 170, or carrier, shown in FIGS. 13a-13 c has ahead section 172 of non-round (here hexagonal) cross-section suitable for engaging with a socket wrench. Themount 170 has a throughpassage 174 extending from thehead section 172 through atail end 176. The throughpassage 174 hasinternal threads 178 in thehead section 172. Thetail end 176 hasexternal threads 180 suitable for engaging thegrooves 125 of the multi-lead thread in thecylinder zone 124 of theimplant 10 of FIGS. 10-11. Longitudinally-directedslots 182 in thetail end 176 extend toward thehead section 172. As seen best in FIG. 13C, fourslots 182 are used in the illustrated embodiment, forming fourfingers 183 in the tail-end 176. Theseslots 182 may all be the same length, or they may have different lengths. In one embodiment, one pair of opposing slots are longer than the intervening pair. Immediately inside thetail end 176, thepassage 174 is partially obstructed withwedge blocks 184, one of which is attached to eachfinger 183. - Between its ends, the
mount 170 has a radially-extendingflange 185 similar to thehead 46 of the cover screws of FIGS. 6 & 7. Theflange 185 includes a reentrant under-surface 187 that engages theouter surface 128 of thegingival end 120. - The
mount screw 190 of FIG. 14 has an externally-threadedsection 192 between itshead end 194 and itstail end 196. Acylindrical shaft 198 extends between the threadedsection 192 and thetail end 196 suitably dimensioned for fitting within thepassage 174 of theimplant mount 170. At thetail end 196, theshaft 198 has a tapered end-section 197 for engaging between the wedge blocks 184 of theimplant mount 170. In itshead end 194, thescrew 190 has a non-round (here shown as hexagonal)socket 200 for engaging a wrench, such as an Allen wrench. - In use, the
implant mount 170 of FIG. 13 is inserted through theimplant passage 118 and threaded via thethreads 180 at itstail end 176 into the threadedcylindrical zone 124 of theimplant 110. In a preferred embodiment, approximately one turn is required to seat theflange 185 of theimplant mount 170 over theouter surface 128 of theimplant 110 using a torque of about 10 N-cm. Themount screw 190 is then inserted through thepassage 174 of theimplant mount 170 and its threadedsection 192 is engaged in theinternal threads 178 in thehead section 172 of themount 170. A suitable wrench engaged in thesocket 200 is useful to drive themount screw 170 into and between the wedge blocks 184 and thereby apply a radially-directed force to spread thetail end 176 within thecylindrical zone 124 using a torque of about 15 N-cm. - The
implant 110 of FIG. 11 with theimplant mount 170 and screw 190 (FIGS. 13 and 14) installed as herein described are carried to the site in the mouth of the patient. Theimplant 110 is installed in the prepared site with a torque required to overcome the cutting of the bone at the self-tapping region. Such torque is generally less than about 40 N-cm. Tests applying torque forces in excess of 100 N-cm have shown that thefingers 184 may be expected to break when the torque exceeds about 120 N-cm which is a far greater torque than would be encountered in a real-life situation. - After the
implant 110 has been installed in the patient's bone, themount 170 is easily removed by loosening thescrew 190 and turning themount 170 in reverse by approximately one turn to release it from theimplant 110. The invention also contemplates an embodiment where thescrew 190 is held captive in thepassage 174 of themount 170 such that both pieces remain together during their removal from the implant. - With regard to the conversion between subgingival and transgingival implants, it is highly desirable for successful dental restoration that the components of a restoration system be precisely dimensioned and that dimensional precision be maintained at every stage in the process of constructing the restoration. For example, implants of the subgingival style are commonly fitted at their occlusal ends with an anti-rotational connecting element for coupling a transgingival component to the implant in a manner that prevents the component from rotating on the implant, around the axis of the implant. These anti-rotational connection elements usually take a hexagonal form, although octagonal forms are also in use. Because of manufacturing tolerance limitations, it is difficult to make hexagonal (for example) posts and sockets that will fit together so tightly that they will not allow some little amount of relative rotation between the connected implant and component. The degree of tightness required to eliminate all relative rotation would make connecting and disconnecting these two parts in the mouth of a patient so difficult that the patient would be unacceptably uncomfortable. A solution to this problem is described in the assignee's copending U.S. patent application Ser. No. 08/451,083, filed May 25, 1995, for “Anti-rotational Connecting Mechanism,” now U.S. Pat. No. 5,725,375.
- Experience has shown that available transition components tend to leave a small gap extending part-way around the periphery of the implant surface. This is believed to be due, at least in part, to the difficulty of accurately attaching restoration components to the transition component. This in turn makes it difficult to achieve and maintain precise axial alignment of the implant, the transition component and the restoration component. Accordingly, in addition to the inventive transgingival style of implant, the present invention addresses the alignment, tolerance, and gap problems as will be shown in FIGS. 15 and 16.
- FIGS. 15 and 16 relate to conversion components for converting between a subgingival and transgingival implant. A
transition component 240 has a lower section designed to fit into theimplant 110 of FIGS. 11-12. This lower section includes a taperedzone 242, anintermediate zone 244 and an externally threadedzone 246 designed to fit in the correspondingzones zone 246 screws into theinnermost zone 126 of the implant, theintermediate zone 244 mates with theintermediate zone 124 of thebore 118, and the taperedzone 242 seats in theoutermost zone 122 of the implant bore 118. A locking taper is formed by the engaging side walls of thezones short thread section 246 is needed on the distal end of the transition component. - The
transition component 240 also has an upper section that extends beyond the occlusal end of the implant. This upper section includes ahexagonal anti-rotation zone 250 and alocator zone 252, extending in sequence supragingivally from the implant when thetransition component 240 is installed in thebore 118. The axial length of thelocator zone 252 is preferably larger than the axial length of theanti-rotation zone 250. Thelocator zone 252 is preferably round in cross-section, and smaller in cross-sectional size than, theanti-rotation zone 250. - A
hollow abutment 260, which performs the function of a non-rotating cylinder used to support an artificial tooth, fits over the upper section of thetransition component 240 and the occlusal surface of theimplant 110. The inside surface of theabutment 260 includes anupper section 262 and alower section 264 separated by aflange 266. Theupper section 262 receives the head of aretainer screw 267, with the screw head resting on the shoulder formed by the upper surface of theflange 266. Thelower section 264 includes alocator zone 268 above the usualhexagonal socket 270, and a flaredskirt 272 extends outwardly and downwardly from the bottom edge of thesocket 270 to the bottom periphery of the abutment. The inside surface of theskirt 270 preferably flares on an angle (measured from the longitudinal axis through the implant and attached components) that is a little smaller than the slope angle of theouter surface 128 of theimplant 110, so that the initial contact between these two surfaces occurs at the bottom edge of theskirt 272. - When the
abutment 260 is fitted to thetransition component 240, thelocator zone 268 of the abutment makes first contact with thelocator zone 252 and serves to align the abutment axially with the transition component. Because the twomating locator zones abutment 260 can be turned around the common axis until theanti-rotation zones abutment 260 can then be seated accurately on thetransition component 240, and theretainer screw 267 can be screwed into the bore 254 and tightened to seat theskirt 272 on theouter surface 128 of theimplant 110. - Because the
mating locator zones abutment 260 as it is fitted over thetransition component 240, theabutment 260 is accurately seated on both thetransition component 240 and theouter surface 128 of theimplant 110, thereby avoiding any microgaps at the interface between the abutment and the implant. As described above, precise alignment is further facilitated by the fact that the outer periphery of theskirt 272 makes first contact with theouter surface 128 of theimplant 110, and further tightening of thescrew 267 increases the annular area of that contact. - The
tube 280 shown in FIGS. 15 and 16 is a known component used to make an artificial tooth using the lost-wax process. Thetube 280, which is typically made of a material that is burned away in the course of the lost-wax process, fits over theabutment 260 down to theskirt 272. A waxingsleeve 282 is provided to cover the skirt. - The invention can be adapted to modification of a subgingival-
style implant 284, as is shown in FIGS. 17 and 18, where parts common with FIGS. 15 and 16 bear the same reference characters. The subgingival-typedental implant 284 is indicated in part under anabutment ring 286 fitted non-rotationally to the anti-rotation (e.g., hexagonal) fitting 288 of theimplant 284. Thisabutment ring 286 has anexterior side surface 289 that mimics the side surface of thetransgingival section 120 of thetransgingival implant 110 shown in FIGS. 11-12, and a slopingtop surface 290 which mimics the slopingouter surface 128 of thetransgingival implant 110. - An
abutment screw 291 attaches theabutment ring 286 to theimplant 284. Thisscrew 291 has a threadedstem 292 which engages the usual threaded bore of theimplant 284. Above thestem 292, cylindrical and taperedhead sections abutment ring 286. The portion of the screw head that projects above theabutment ring 286 is identical to the upper section of thetransition component 240 described above. In other words, the head of thescrew 291 includes alocater region 295 and an anti-rotation 296 (e.g. hexagonal boss) that are similar tolocater zone 252 andanti-rotation zone 250 of thetransition component 240. All the other parts shown in FIGS. 17 and 18 are the same as the corresponding parts in FIGS. 15 and 16. Thus, theabutment 260 and thetube 280 can be used with thesubgingival implant 284 after it has been fitted withring 286. - FIGS. 19-25 relate to caps which engage the post of a transgingival implant. In the first embodiment of the invention shown in FIGS. 19-21, a
cap 310 has a generally cylindrical-shapedouter sidewall 312 and a taperedinner sidewall 314. Thiscap 310 has anopen bottom 316 bounded by arim 318 enclosing anannular channel 320. Theouter sidewall 310 turns inward at the bottom 311 toward therim 318. At the top 322 the cap has a dome-shapedtop wall 324 with ahole 326 through it. The cap is preferably made of a resilient polymeric material that retains its shape, such as “Delrin.” - In a second embodiment of the cap invention shown in FIGS. 22-24, a
cap 330 has anopen bottom 331 bounded by arim 333 enclosing anannular channel 335 like the same parts of thecap 310 in FIGS. 19-21. The top 332 of thecap 330 is open and surrounded by anannular rim 334. The inwardly-taperingbottom portion 337 of the sidewall has an upwardly-facingannular shoulder 328 at its upper end. Between thisshoulder 328 and thetop rim 334 are severaladditional rims shoulder 328 to thetop rim 334. Theshoulder 328 has the largest outer diameter, and thetop rim 334 has the smallest outer diameter. A series of generallytubular sidewall sections shoulder 328 and theadjacent rim 336, then rim 336 andrim 338, then rim 338 andrim 340, and finally rim 340 andrim 334. The diameters of these sidewall sections decrease progressively from theshoulder 328 to the top 332 of thecap 330, so that the overall shape of thecap 330 is tapered in diameter from thelower opening 316 to theupper opening 332. Each sidewall section hasperforations 349 through it. - The
caps dental implant 350, by forcing therims peripheral surface 354 at the bottom of an expandingsloping surface 352 at the top of theimplant 350. Theannular channels implant 350 so the upper portions of thechannels sloping surface 352, while the lower portions of thechannels surface 355 directly beneath therim 354. To enable this lowermost portion of the cap to pass therim 354 of the implant, the caps are preferably made of a resilient material so that downward pressure urging the lower rims of thecap implant surface 352 cams therim 318 outwardly, thereby temporarily expanding the diameter of the bottom opening of thecap 330 until therim 318 clears theimplant rim 354. The resilience of thecap 330 then causes therim 318 to snap back to its original diameter, against the inwardly taperingsurface 355 beneath therim 354. It will be appreciated that this same type of “snap action” may be used to hold the cap in virtually any undercut surface configuration near the top of an implant. As can be seen in FIG. 24, in its final installed position thecap 330 surrounds apost 356 that is in place on theimplant 350. - In an alternative embodiment, the
rims rims caps implant 350 along the uppersloping surface 352 and the small cylindrical band of the implant (at its widest diameter) just above the inwardly taperingsurface 355. This band is usually about 0.004 in to 0.010 inch in height, although it could be made larger. Thus, therims caps implant 350 but does not engage the inwardly taperingsurface 355 of theimplant 350. - The
cap 310 can be used by itself as a temporary tooth. The clinician applies a cement to the inside surface of thecap 310 and places it on the post. The excess cement then can vacate the cavity under thecap 310 through thehole 326. Because thecap 310 by itself serves as a temporary tooth and is made of relatively inexpensive plastic materials, the invention contemplates producing the cap in various sizes and shapes to generally mimic the outer contours of natural teeth. Thus, the clinician would select the size and shape that would best correspond to the conditions in the patient's mouth. Alternatively, thecap 310 could be modified by the clinician to produce a more esthetically pleasing contour. Furthermore,cap 310 can be simply used without cement for a short time (less than two days for example) to get the patient from the periodontist to the restorative dentist. - Also, the
cap 310 can form the gingiva at itsbottom 311. While in some instances a clinician will place theimplant 350 such that its uppersloping surface 352 is at or above the outer gingival surface, some clinicians may place theimplant 350 such that its uppersloping surface 352 is well below the gingival surface. Thus, thecap 310 may engage and form the gingiva for 2 mm to 3 mm above its lowermost surface. - Because the
cap 310 will form a ring-shaped cavity in the gingiva adjacent to and around the inwardly taperingsurface 355, thecap 310 is useful prior to taking an impression because it is beneficial to slightly move the gingival tissue away from theimplant 350 before the impression process. Thus, the impression material can flow into this ring-shaped cavity to obtain a better impression of the region along the inwardly taperingsurface 355 of theimplant 350. While this process of displacing the gingival tissue occurs after thecap 310 has been positioned on the implant for some time (e.g. one day to one week), it can be expedited to just a few minutes by dipping thebottom 311 of thecap 310 in gingival retraction chemicals which results in the gingiva tightening and pulling away from theimplant 350. Thus, the ring-shaped cavity is created due to the mechanical action of thecap 310 and the chemical action of the gingiva retraction chemical. Furthermore, it is possible to produce thecap 310 or just its bottom 311 from a porous material to enhance the ability of the cap to retain the gingival retraction chemical prior to its release into the gingival tissue. - To achieve a temporary tooth that is cosmetically pleasing and can last for several months, the
cap 330 of FIGS. 22-23 should be used, as is illustrated in FIG. 24. An appropriately-shapedshell 360, chosen to mimic the tooth being restored, is filled (wholly or partially as desired) with a quantity of a dental plastic material (e.g., acrylic) that hardens slowly, and the “filled” shell is placed over the cap as is illustrated in FIG. 25, and manipulated to force the plastic material (not shown in FIG. 25) through theperforations 349 into contact with thepost 356. The spaces between theshell 360 and thecap 330, and between thecap 330 and the post 356 (not shown in FIG. 25) will be filled with the hardening plastic material. In practice, the clinician preparing the temporary tooth will gently seat and remove theshell 360 and thecap 330 with the hardening material around thepost 356 while the plastic material hardens. When the plastic material has hardened, that person will remove this assembly from the post for final preparation of the temporary tooth. If the tooth is being prepared in patient's mouth where the site has one or two adjacent teeth, it may be desired to remove therim 333 of thecap 330 from theimplant 350, at least until preparation of the tooth is completed. If the tooth is being prepared on a model outside the patient's mouth, where the site can be isolated, therim 333 can be usefully retained, because the final temporary tooth need not extend below the implant rim 354 (and the hardening of the temporary tooth material around thecap 330 may reduce the flexibility of the rim 333). In either case, in the final preparation of the tooth, theshell 360 may be removed and the hardened plastic material may be shaped and polished, and then cemented in place on thepost 356 with a suitable dental cement. It will be appreciated that FIG. 25 is not drawn to scale. In practice, the shell may be closer to the post than this illustration shows it. While no acrylic (or other suitable tooth-forming material) has been illustrated, such materials are well-known in the dental art. - The
cap 330 may be adjusted in length to match the length of thepost 356 by cutting thecap 330 at the top of any of theintermediate rims post 356 which extends to theuppermost rim 334 at thetop opening 332. If a shorter post is used, thecap 330 can be shortened to match the post by removing that portion of thecap 330 above thefirst rim 340 beyond the top of post. Preferably, therims - The invention is not limited to the physical configurations of the implant and the caps that are illustrated herein by way of example. The dental arts include a wide variety of implants and posts and abutments designed for use with them. The invention is intended to apply to all such to which it can be adapted.
Claims (44)
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US6080197P | 1997-10-03 | 1997-10-03 | |
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US09/164,934 US6217331B1 (en) | 1997-10-03 | 1998-10-01 | Single-stage implant system |
US09/731,589 US6394809B2 (en) | 1997-10-03 | 2000-12-07 | Single-stage implant system |
US10/154,875 US20020142266A1 (en) | 1997-10-03 | 2002-05-24 | Single-stage implant system |
US10/837,801 US20040209226A1 (en) | 1997-10-03 | 2004-05-03 | Single-stage implant system |
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US10/154,875 Abandoned US20020142266A1 (en) | 1997-10-03 | 2002-05-24 | Single-stage implant system |
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US20040101806A1 (en) * | 2002-09-12 | 2004-05-27 | Ajay Kumar | Dental impression coping with retention |
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US20080014556A1 (en) * | 2004-06-04 | 2008-01-17 | Stefan Neumeyer | Tooth Implant |
US20110111370A1 (en) * | 2004-06-04 | 2011-05-12 | Stefan Neumeyer | Tooth implant |
US20070016207A1 (en) * | 2005-07-01 | 2007-01-18 | Endelman Ken | Skull pin apparatus |
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US20170056135A1 (en) * | 2008-12-11 | 2017-03-02 | Aeton Medical Llc | Fixtures for dental implants |
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US20120237900A1 (en) * | 2009-12-04 | 2012-09-20 | Anthogyr | Conically tapered dental implant |
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US9980792B2 (en) * | 2013-06-07 | 2018-05-29 | Paul Ouellette | Hybrid temporary anchorage device implant system and associated methods |
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US20170202649A1 (en) * | 2014-07-25 | 2017-07-20 | Nobel Biocare Services Ag | Provisional prosthetic systems and methods of using same |
US10159545B2 (en) * | 2015-07-31 | 2018-12-25 | Jjgc Indústria E Comércio De Materiais Dentários S.A. | Scanbody |
US20170027667A1 (en) * | 2015-07-31 | 2017-02-02 | Jjgc Indústria E Comércio De Materiais Dentários S.A. | Scanbody |
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WO2018042420A1 (en) * | 2016-08-31 | 2018-03-08 | Andy Boiangiu | Dental implant cover |
US11344389B2 (en) * | 2016-12-01 | 2022-05-31 | Dentsply Implants Manufacturing Gmbh | Arrangement comprising an abutment post and an appurtenant cap, as well as a tool for application of the cap |
USD872264S1 (en) | 2017-07-19 | 2020-01-07 | Jjgc Indústria E Comércio De Materiais Dentários | Dental implant |
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Also Published As
Publication number | Publication date |
---|---|
DE69834411T2 (en) | 2006-09-28 |
ATE384484T1 (en) | 2008-02-15 |
AU9686498A (en) | 1999-04-27 |
US20010000748A1 (en) | 2001-05-03 |
EP1018972A2 (en) | 2000-07-19 |
DE69839063T2 (en) | 2008-05-15 |
US6394809B2 (en) | 2002-05-28 |
US20020142266A1 (en) | 2002-10-03 |
JP2001518348A (en) | 2001-10-16 |
WO1999017676A2 (en) | 1999-04-15 |
ES2300690T3 (en) | 2008-06-16 |
DE69839063D1 (en) | 2008-03-13 |
DE69834411D1 (en) | 2006-06-08 |
JP4073164B2 (en) | 2008-04-09 |
EP1018972B1 (en) | 2006-05-03 |
US6217331B1 (en) | 2001-04-17 |
ES2263223T3 (en) | 2006-12-01 |
KR20010030908A (en) | 2001-04-16 |
ATE324839T1 (en) | 2006-06-15 |
WO1999017676A3 (en) | 1999-07-29 |
BR9815241A (en) | 2002-07-23 |
AR014917A1 (en) | 2001-04-11 |
TW480169B (en) | 2002-03-21 |
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