US20040167610A1 - Locking stent - Google Patents
Locking stent Download PDFInfo
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- US20040167610A1 US20040167610A1 US10/374,211 US37421103A US2004167610A1 US 20040167610 A1 US20040167610 A1 US 20040167610A1 US 37421103 A US37421103 A US 37421103A US 2004167610 A1 US2004167610 A1 US 2004167610A1
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- stent
- stent according
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- hoop
- configuration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M29/00—Dilators with or without means for introducing media, e.g. remedies
- A61M29/02—Dilators made of swellable material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/9155—Adjacent bands being connected to each other
- A61F2002/91583—Adjacent bands being connected to each other by a bridge, whereby at least one of its ends is connected along the length of a strut between two consecutive apices within a band
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/9155—Adjacent bands being connected to each other
- A61F2002/91591—Locking connectors, e.g. using male-female connections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/0054—V-shaped
Definitions
- the present invention relates, in general, to intralumenal medical devices, and, more particularly, two a new and useful stent having interlocking elements for stenting a vessel.
- a stent is commonly used as a tubular structure left inside the lumen of a duct to relieve an obstruction.
- stents are inserted into the lumen in a non-expanded form and are then expanded autonomously (or with the aid of a second device) in situ.
- stents are placed percutaneously through the femoral artery.
- stents are delivered on a catheter and are either self-expanding or, in the majority of cases, expanded by a balloon. Self-expanding stents do not need a balloon to be deployed.
- the stents are constructed using metals with spring-like or superelastic properties (i.e., Nitinol), which inherently exhibit constant radial support.
- Self-expanding stents are also often used in vessels close to the skin (i.e., carotid arteries) or vessels that can experience a lot of movement (i.e., popliteal artery). Due to a natural elastic recoil, self-expanding stents withstand pressure or shifting and maintain their shape.
- the typical method of expansion for balloon expanded stents occurs through the use of a catheter mounted angioplasty balloon, which is inflated within the stenosed vessel or body passageway, in order to shear and disrupt the obstructions associated with the wall components of the vessel and to obtain an enlarged lumen.
- balloon-expandable stents are available either pre-mounted or unmounted.
- a pre-mounted system has the stent already crimped on a balloon, while an unmounted system gives the physician the option as to what combination of devices (catheters and stents) to use.
- the stent is first introduced into the blood vessel on a balloon catheter. Then, the balloon is inflated causing the stent to expand and press against the vessel wall. After expanding the stent, the balloon is deflated and withdrawn from the vessel together with the catheter. Once the balloon is withdrawn, the stent stays in place permanently, holding the vessel open and improving the flow of blood.
- the present invention relates to an apparatus and method for stenting a vessel in conjunction with a particular new and useful stent having a lattice of interconnecting elements defining a substantially cylindrical configuration.
- the lattice has a first open end and a second open end wherein the lattice is movable between a closed configuration and an open configuration.
- the lattice comprises a plurality of adjacent hoops wherein each hoop is separated from another hoop in the closed configuration and each hoop interlocks with another hoop in the open configuration.
- Each hoop comprises a plurality of loops. And, each hoop further comprises a plurality of struts connected to the loops.
- At least one loop of one hoop comprises a male end and at least one loop of another hoop comprises a female end.
- the male end is separated from the female end when the lattice is in the closed configuration.
- the male end is connectably mated to the female end when the lattice is moved to the open configuration thereby locking the stent lattice in the open configuration.
- the lattice further comprises at least one flexible link or a plurality of flexible links connected between adjacent hoops.
- the flexible links comprise various shapes such as a sinusoidal shaped, straight or linear shape, or a substantially S-shaped or Z-shaped pattern. At least one flexible link is connected between loops of adjacent hoops of the lattice.
- the plurality of struts and the loops define at least one pre-configured cell.
- the lattice comprises a plurality of pre-configured cells defined by the plurality of struts and the loops of the lattice.
- the plurality of struts and the loops also define at least one partial cell.
- the plurality of struts and the loops define a plurality of partial cells.
- a partial cell is defined by the plurality of struts and the loops when the lattice is in the closed configuration.
- the plurality of struts and the loops define at least one formed cell.
- the plurality of struts and the loops of the stent lattice define a plurality of formed cells.
- a formed cell is defined by the plurality of struts and the loops when the lattice is moved into the open configuration (locked configuration).
- the male end of the at least one loop of one hoop has a substantially convex configuration.
- the female end of at least one loop of another hoop has a substantially concave configuration.
- alternative forms, shapes or configurations for the male end and female end respectively are also contemplated herein.
- each pre-configured cell has a substantially diamond shape.
- Other shapes for the pre-configured cell are also contemplated by the present invention, and thus, the pre-configured cell may take the form of any desired shape.
- the stent lattice further comprises a drug coating or a drug and polymer coating combination.
- the drug is rapamycin.
- the drug is paclitaxel.
- Other drugs and drug polymer combinations are also contemplated by the present invention and examples are provided later in this disclosure.
- the stent of the present invention is directed toward both a balloon actuated stent and a self-expanding stent.
- the stent is made of any suitable material.
- the stent is made of an alloy such as stainless steel.
- the stent is made of a nickel titanium (Nitinol) alloy.
- this material or any other super-elastic alloy is suitable for the stent according to the present invention.
- the stent is a crush recoverable stent.
- FIG. 1 is a perspective view of a of a stent in a closed-configuration in accordance with the present invention
- FIG. 2 is a partial side plan view of the stent of FIG. 1A in the closed configuration in accordance with the present invention
- FIG. 3 is a perspective view of the stent of FIG. 1 in an open configuration in accordance with the present invention
- FIG. 4 is a partial side view of the stent of FIG. 1 in the open configuration in accordance with the present invention.
- FIGS. 1 - 4 a stent 100 that is an expandable prosthesis for a body passageway is illustrated.
- the terms “stent” and “prosthesis” are interchangeably used to some extent in describing the present invention, insofar as the method, apparatus, and structures of the present invention may be utilized not only in connection with an expandable intraluminal vascular graft for expanding partially occluded segments of a blood vessel, duct or body passageways, such as within an organ, but may so be utilized for many other purposes as an expandable prosthesis for many other types of body passageways.
- expandable prostheses may also be used for such purposes as: (1) supportive graft placement within blocked arteries opened by transluminal recanalization, but which are likely to collapse in the absence of internal support; (2) similar use following catheter passage through mediastinal and other veins occluded by inoperable cancers; (3) reinforcement of catheter created intrahepatic communications between portal and hepatic veins in patients suffering from portal hypertension; (4) supportive graft placement of narrowing of the esophagus, the intestine, the ureters, the uretha, etc.; (5) intraluminally bypassing a defect such as an aneurysm or blockage within a vessel or organ; and (6) supportive graft reinforcement of reopened and previously obstructed bile ducts.
- body passageway encompasses any lumen or duct within the human body, such as those previously described, as well as any vein, artery, or blood vessel within the human vascular system.
- the stent 100 is an expandable lattice structure made of any suitable material which is compatible with the human body and the bodily fluids (not shown) with which the stent 100 may come into contact.
- the lattice structure is an arrangement of interconnecting elements made of a material which has the requisite strength and elasticity characteristics to permit the tubular shaped stent 100 to be moved or expanded from a closed (crimped) position or configuration shown in FIGS. 1 and 2 to an expanded or open position or configuration shown in FIGS. 2 and 3.
- Some examples of materials that are used for the fabrication of the stent 100 include silver, tantalum, stainless steel, gold, titanium or any type of plastic material having the requisite characteristics previously described.
- the stent 100 in accordance with the present invention is also made of these type of plastics or polymers to include biodegradable polymers.
- the biodegradable polymers used as material for the stent 100 can be drug eluting polymers capable of eluting a therapeutic and/or pharmaceutical agent according to any desired release profile.
- the stent is fabricated from 316L stainless steel alloy.
- the stent 100 comprises a superelastic alloy such as nickel titanium (NiTi, e.g., Nitinol). More preferably, the stent 100 is formed from an alloy comprising from about 50.5 to 60.0% Ni by atomic weight and the remainder Ti. Even more preferably, the stent 100 is formed from an alloy comprising about 55% Ni and about 45% Ti.
- the stent 100 is preferably designed such that it is superelastic at body temperature, and preferably has an Af temperature in the range from about 24° C. to about 37° C. The superelastic design of the stent 100 makes it crush recoverable and thus suitable as a stent or frame for any number of vascular devices for different applications.
- the stent 100 comprises a tubular configuration formed by a lattice of interconnecting elements defining a substantially cylindrical configuration and having front and back open ends 102 , 104 and defining a longitudinal axis extending therebetween. In its closed configuration, the stent 100 has a first diameter for insertion into a patient and navigation through the vessels and, in its open configuration, a second diameter, as shown in FIG. 3, for deployment into the target area of a vessel with the second diameter being greater than the first diameter.
- the stent 100 comprises a plurality of adjacent hoops 106 a - 106 h extending between the front and back ends 102 , 104 .
- the stent 100 comprises any combination or number of hoops 106 .
- the hoops 106 a - 106 h include a plurality of longitudinally arranged struts 108 and a plurality of loops 110 connecting adjacent struts 108 .
- Adjacent struts 108 or loops 110 are connected at opposite ends by flexible links 114 which can be any pattern such as sinusoidal shape, straight (linear) shape or a substantially S-shaped or Z-shaped pattern.
- the plurality of loops 110 have a substantially curved configuration.
- the flexible links 114 serve as bridges, which connect adjacent hoops 106 a - 106 h at the struts 108 or loops 110 .
- Each flexible link comprises two ends wherein one end of each link 114 is attached to one strut 108 or one loop 110 on one hoop 106 a and the other end of the link 114 is attached to one strut 108 or one loop 110 on an adjacent hoop 106 b, etc.
- the above-described geometry better distributes strain throughout the stent 100 , prevents metal to metal contact where the stent 100 is bent, and minimizes the opening between the features of the stent 100 ; namely, struts 108 , loops 110 and flexible links 114 .
- the number of and nature of the design of the struts, loops and flexible links are important design factors when determining the working properties and fatigue life properties of the stent 100 . It was previously thought that in order to improve the rigidity of the stent, struts should be large, and thus there should be fewer struts 108 per hoop 106 a - 106 h.
- each hoop 106 a - 106 h has between twenty-four (24) to thirty-six (36) or more struts 108 . It has been determined that a stent having a ratio of number of struts per hoop to strut length which is greater than four hundred has increased rigidity over prior art stents which typically have a ratio of under two hundred. The length of a strut is measured in its compressed state (closed configuration) parallel to the longitudinal axis of the stent 100 as illustrated in FIG. 1.
- FIG. 3 illustrates the stent 100 in its open or expanded state.
- the geometry of the stent 100 changes quite significantly as it is deployed from its unexpanded state (closed or crimped configuration/position) to its expanded state (open or expanded configuration/position).
- the strut angle and strain levels in the loops 110 and flexible links 114 are affected.
- all of the stent features will strain in a predictable manner so that the stent 100 is reliable and uniform in strength.
- Nitinol properties are more generally limited by strain rather than by stress.
- the embodiment illustrated in FIGS. 1 - 4 has a design to help minimize forces such as strain.
- the stent 100 in the closed-configuration (crimped configuration wherein the stent 100 is crimped on the stent delivery device such as a catheter), has a plurality of pre-configured cells 120 a.
- Each pre-configured cell 120 a is defined by the struts 108 and loops 110 connected to each other respectively thereby defining an open area in the stent lattice 100 .
- This open area is a space identified as the pre-configured cell 120 a.
- Each hoop 106 a - 106 h has one or more (or a plurality of) pre-configured cells 120 a.
- the pre-configured cell 120 a is a diamond-shaped area or space.
- the pre-configured cell 120 a take the form of any desired alternative shape.
- the stent lattice 100 also includes at least one (or a plurality of) partial cells 120 b.
- Each partial cell 120 b is defined by struts 108 and one loop 110 of the respective hoops 106 a - 106 h.
- the partial cell 120 b defines a semi-enclosed area or space having an open end in direct communication with a loop 110 from an adjacent hoop 106 a - 106 h.
- the flexible link 114 connects adjacent hoops, for example hoop 106 b to hoop 106 c, by having one end of flexible link 114 connected to an inner surface of loop 110 of a partial cell 120 b of the hoop 106 b and the opposite end of the flexible link 114 connected to loop 110 of the adjacent hoop 106 c.
- the flexible link 114 extends from one end of the partial cell 120 b, for instance, of hoop 106 b and extends through the semi-enclosed area of the partial cell 120 b and is connected to loop 110 of the adjacent hoop 106 c.
- the flexible links 114 are connected between adjacent hoops 106 a - 106 h by extension through the partial cells 120 b.
- the partial cell 120 b is not only a semi-enclosed area or space defined by struts 108 and one loop 110 of each hoop 106 , but the partial cell 120 b may take the form of any desired semi-enclosed shape.
- each partial cell 120 b of the stent lattice 100 exists while the stent 100 is in its crimped state or closed configuration, i.e. crimped to the delivery device such as a catheter.
- each pre-configured cell 120 a has one loop 110 terminating in a male end 130 and the other loop defining the pre-configured cell 120 a terminating in a female and 140 .
- the male end 130 of one loop 110 and the female end 140 of the other loop 110 of the pre-configured cell 120 a are positioned opposite each other thereby defining opposite ends of the pre-configured cell 120 a, for example opposite ends of the diamond-shaped area in this embodiment.
- the male end 130 has a substantially convex configuration and the female end 140 has a substantially concave configuration.
- the female end 140 is designed such that it is shaped to receive and mateably connect with the male end 130 . Accordingly, in this embodiment, the substantially concave surface of the female end 140 mateably connects with the substantially convex shape of the male end 130 when the stent lattice 100 is moved to the open configuration or state (deployed or expanded state) such as shown in FIGS. 3 and 4.
- the male end 130 of the loop 110 of one hoop 106 mateably connects with the female end 140 of an opposite loop 110 of an adjacent hoop, for example 106 c, thereby forming a locked joint 150 .
- the male end 130 and the female end 140 may take the form of any desired shape or configuration that permits the male end 130 to mateably connect with the female end 140 in order to form the locked joint 150 .
- the male end 130 and the female end 140 may be shaped respectively in order to form portions of a dove-tail such that the locked joint 150 has or forms a dove-tail configuration.
- Other shapes for the male end 130 and female end 140 forming the locked joint 150 are also contemplated herein.
- adjacent hoops 106 a - 106 h interlock with each other at the newly formed joints 150 mateably connecting adjacent hoops 106 a - 106 h.
- the hoop 106 b mateably connects or interlocks with the adjacent hoop 106 c and the hoop 106 c interlocks with the adjacent hoop 106 d, etc.
- the points of interlocking or mateable connection are located at the newly formed locked joint 150 between each pair of adjacent hoops 106 as shown.
- each locked joint 150 is formed by at least one loop 110 of one hoop 106 (for example 106 b, wherein the male end 130 of this loop 110 mateably connects with the female end 140 of another loop 110 ), i.e. an adjacent loop on an adjacent hoop 106 , for example loop 110 on the hoop 106 c which is directly opposed from the male end 130 of loop 110 of the hoop 106 b. Therefore, the adjacent hoops 106 a - 106 h, are mateably connected to or locked to each other respectively at each locked joint 150 formed in a manner such as described above.
- a formed cell 120 c is created or formed between adjacent locked joints 150 form by a pair of interlocking, adjacent hoops 106 , for example, 106 a and 106 b, etc.
- Each formed cell 120 c is a fully enclosed area or space defined by the struts 108 loops 110 and locked joints 150 formed by the adjacent hoops 106 , i.e. linking of hoop 106 a to hoop 106 b, linking of hoop 106 b to adjacent hoop 106 c, etc.
- the partial cell 120 b (FIG. 2) of the stent lattice 100 in its crimped configuration, becomes the formed cell 120 c when linked or coupled by the locked joint 150 between adjacent hoops 106 as shown in FIG. 4.
- the stent 100 has flexible links 110 that may be on one or more of the following components of the stent lattice: the hoops 106 a - 106 h, the loops 110 , and/or the struts 108 .
- the components of the stent lattice i.e. hoops, loops, struts and flexible links, have drug coatings or drug and polymer coating combinations that are used to deliver drugs, i.e. therapeutic and/or pharmaceutical agents including: antiproliferative/antimitotic agents including natural products such as vinca alkaloids (i.e.
- paclitaxel i.e. etoposide, teniposide
- antibiotics dactinomycin (actinomycin D) daunorubicin, doxorubicin and idarubicin
- anthracyclines mitoxantrone, bleomycins, plicamycin (mithramycin) and mitomycin
- enzymes L-asparaginase which systemically metabolizes L-asparagine and deprives cells which do not have the capacity to synthesize their own asparagine
- antiplatelet agents such as G(GP)II b III a inhibitors and vitronectin receptor antagonists
- antiproliferative/antimitotic alkylating agents such as nitrogen mustards (mechlorethamine, cyclophosphamide and analogs, melphalan, chlorambucil), ethylenimines and
- anticoagulants heparin, synthetic heparin salts and other inhibitors of thrombin
- fibrinolytic agents such as tissue plasminogen activator, streptokinase and urokinase), aspirin, dipyridamole, ticlopidine, clopidogrel, abciximab
- antimigratory antisecretory (breveldin)
- antiinflammatory such as adrenocortical steroids (cortisol, cortisone, fludrocortisone, prednisone, prednisolone, 6 ⁇ -methylprednisolone, triamcinolone, betamethasone, and dexamethasone), non-steroidal agents (salicylic acid derivatives i.e.
- the lattice components e.g. hoops, loops, struts and flexible links
- the stent 100 is alternatively made of a polymer material itself such as a biodegradable material capable of containing and eluting one or more drugs, in any combination, in accordance with a specific or desired drug release profile.
- the method of utilizing the stent 100 includes first identifying a location, for example, a site within the vessel in a patient's body for deployment of the stent 100 .
- a delivery device such as a catheter carrying the stent 100 crimped to a distal end of the catheter such that the stent 100 is in its closed configuration, is inserted within the vessel in the patient's body.
- the catheter is used to traverse the vessel until reaching the desired location (site) wherein the distal end of the catheter is positioned at the desired location (site), for instance the lesion, within the vessel.
- the stent 100 is deployed to its open configuration by expanding the stent 100 such as by inflation if the stent 100 is a balloon expandable stent or by uncovering or release of the stent 100 if the stent 100 is a self-expanding (crush recoverable) type stent. If a cover is utilized to further protect and secure the stent 100 to the catheter distal end when the stent 100 is a self-expanding stent, the cover is removed from the distal end of the catheter prior to expansion of the stent 100 , for instance, through use of an expandable member such as an inflatable balloon.
- an expandable member such as an inflatable balloon.
- the expandable member (balloon) is then collapsed, for instance through deflation of the expandable member, whereby the catheter is removed from the deployment site of the vessel and patient's body altogether.
- the unique design of the stent 100 i.e. the interlocking of adjacent hoops 106 upon deployment of the stent 100 , allows for a wide array of materials, not previously used with prior art stents, to be used with the stent 100 in accordance with the present invention. These include materials normally prone to crushing, deformation or recoil upon deployment of the stent. These materials include plastics and polymers to include biodegradable polymers such as drug eluting polymers.
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Physics & Mathematics (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Optics & Photonics (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Prostheses (AREA)
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/374,211 US20040167610A1 (en) | 2003-02-26 | 2003-02-26 | Locking stent |
CA2457696A CA2457696C (fr) | 2003-02-26 | 2004-02-10 | Tuteur intravasculaire verrouillable |
IL16030204A IL160302A0 (en) | 2003-02-26 | 2004-02-10 | Locking stent |
AU2004200611A AU2004200611B2 (en) | 2003-02-26 | 2004-02-16 | Locking stent |
EP04250846A EP1452152B1 (fr) | 2003-02-26 | 2004-02-18 | Stent avec verrouillage |
DE602004020290T DE602004020290D1 (fr) | 2003-02-26 | 2004-02-18 | |
AT04250846T ATE427077T1 (de) | 2003-02-26 | 2004-02-18 | Mit einem verschluss ausgestatteter stent |
JP2004049881A JP4744810B2 (ja) | 2003-02-26 | 2004-02-25 | 係止型ステント |
KR1020040012897A KR101052188B1 (ko) | 2003-02-26 | 2004-02-26 | 로킹 스텐트 |
US10/834,687 US20040249442A1 (en) | 2003-02-26 | 2004-04-29 | Locking stent having multiple locking points |
US10/931,163 US7854757B2 (en) | 2003-02-26 | 2004-08-31 | Biodegradable intralumenal device |
US11/435,195 US20080051866A1 (en) | 2003-02-26 | 2006-05-16 | Drug delivery devices and methods |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/374,211 US20040167610A1 (en) | 2003-02-26 | 2003-02-26 | Locking stent |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/834,687 Continuation-In-Part US20040249442A1 (en) | 2003-02-26 | 2004-04-29 | Locking stent having multiple locking points |
US10/931,163 Continuation US7854757B2 (en) | 2003-02-26 | 2004-08-31 | Biodegradable intralumenal device |
Publications (1)
Publication Number | Publication Date |
---|---|
US20040167610A1 true US20040167610A1 (en) | 2004-08-26 |
Family
ID=32771436
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/374,211 Abandoned US20040167610A1 (en) | 2003-02-26 | 2003-02-26 | Locking stent |
US10/931,163 Active 2024-08-14 US7854757B2 (en) | 2003-02-26 | 2004-08-31 | Biodegradable intralumenal device |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/931,163 Active 2024-08-14 US7854757B2 (en) | 2003-02-26 | 2004-08-31 | Biodegradable intralumenal device |
Country Status (9)
Country | Link |
---|---|
US (2) | US20040167610A1 (fr) |
EP (1) | EP1452152B1 (fr) |
JP (1) | JP4744810B2 (fr) |
KR (1) | KR101052188B1 (fr) |
AT (1) | ATE427077T1 (fr) |
AU (1) | AU2004200611B2 (fr) |
CA (1) | CA2457696C (fr) |
DE (1) | DE602004020290D1 (fr) |
IL (1) | IL160302A0 (fr) |
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JP2004255193A (ja) | 2004-09-16 |
EP1452152B1 (fr) | 2009-04-01 |
US7854757B2 (en) | 2010-12-21 |
AU2004200611A1 (en) | 2004-09-16 |
ATE427077T1 (de) | 2009-04-15 |
EP1452152A2 (fr) | 2004-09-01 |
EP1452152A3 (fr) | 2006-07-12 |
IL160302A0 (en) | 2004-07-25 |
CA2457696C (fr) | 2011-01-25 |
JP4744810B2 (ja) | 2011-08-10 |
CA2457696A1 (fr) | 2004-08-26 |
DE602004020290D1 (fr) | 2009-05-14 |
US20050033413A1 (en) | 2005-02-10 |
KR20040076816A (ko) | 2004-09-03 |
KR101052188B1 (ko) | 2011-07-29 |
AU2004200611B2 (en) | 2009-08-27 |
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