US20040163648A1 - Bio-mask with integral sensors - Google Patents

Bio-mask with integral sensors Download PDF

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Publication number
US20040163648A1
US20040163648A1 US10777572 US77757204A US2004163648A1 US 20040163648 A1 US20040163648 A1 US 20040163648A1 US 10777572 US10777572 US 10777572 US 77757204 A US77757204 A US 77757204A US 2004163648 A1 US2004163648 A1 US 2004163648A1
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mask
sensors
patient
gas
sensor
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US10777572
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David Burton
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David Burton
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802Sensor mounted on worn items
    • A61B5/6803Head-worn items, e.g. helmets, masks, headphones or goggles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/04Detecting, measuring or recording bioelectric signals of the body or parts thereof
    • A61B5/0402Electrocardiography, i.e. ECG
    • A61B5/0408Electrodes specially adapted therefor
    • A61B5/04085Multiple electrode holders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/08Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/087Measuring breath flow
    • A61B5/0878Measuring breath flow using temperature sensing means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/021Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes operated by electrical means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/06Respiratory or anaesthetic masks
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/06Respiratory or anaesthetic masks
    • A61M16/0605Means for improving the adaptation of the mask to the patient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/06Respiratory or anaesthetic masks
    • A61M16/0605Means for improving the adaptation of the mask to the patient
    • A61M16/0633Means for improving the adaptation of the mask to the patient with forehead support
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/06Respiratory or anaesthetic masks
    • A61M16/0683Holding devices therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/06Respiratory or anaesthetic masks
    • A61M16/0683Holding devices therefor
    • A61M16/0694Chin straps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/04Detecting, measuring or recording bioelectric signals of the body or parts thereof
    • A61B5/0476Electroencephalography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/04Detecting, measuring or recording bioelectric signals of the body or parts thereof
    • A61B5/0488Electromyography
    • A61B5/0492Electrodes specially adapted therefor, e.g. needle electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/08Bellows; Connecting tubes ; Water traps; Patient circuits
    • A61M16/0816Joints or connectors
    • A61M16/0841Joints or connectors for sampling
    • A61M16/0858Pressure sampling ports
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M2016/0027Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/02General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0238General characteristics of the apparatus characterised by a particular materials the material being a coating or protective layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00Measuring parameters of the user
    • A61M2230/04Heartbeat characteristics, e.g. ECG, blood pressure modulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00Measuring parameters of the user
    • A61M2230/08Other bio-electrical signals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00Measuring parameters of the user
    • A61M2230/08Other bio-electrical signals
    • A61M2230/10Electroencephalographic signals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00Measuring parameters of the user
    • A61M2230/20Blood composition characteristics
    • A61M2230/205Blood composition characteristics partial oxygen pressure (P-O2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00Measuring parameters of the user
    • A61M2230/30Blood pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00Measuring parameters of the user
    • A61M2230/50Temperature
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00Measuring parameters of the user
    • A61M2230/60Muscle strain, i.e. measured on the user
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00Measuring parameters of the user
    • A61M2230/62Posture
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00Measuring parameters of the user
    • A61M2230/63Motion, e.g. physical activity

Abstract

A gas mask for use with associated monitoring and controlling apparatus is provided. A device for monitoring of patients with sleep disorders, breathing disorders or for anesthesia is provided. Different types of sensors on or in the mask and straps or caps connected to the mask include but are not limited to oximetery sensors, patient position sensors, eye movement sensors, leak detection sensors, EEG, EMG, EOG, ECG, PTT, microphones, pulse, blood pressure, oxygen saturation, temperature, movement sensors, position sensors, light sensors, leak detection sensors and gas delivery sensors. Another application provides for gas delivery to a bio-mask controlled, in part, via communication from a pacemaker to a bio-mask controller.

Description

    RELATED APPLICATIONS
  • [0001]
    This application is a continuation-in-part of U.S. Ser. No. 09/465,054, filed Dec. 16, 1999, and incorporated herein in its entirety.
  • BACKGROUND OF THE INVENTION
  • [0002]
    1. Field of the Invention
  • [0003]
    This invention relates to a breathing mask with built in sensors for monitoring patients with sleep apnea, breathing disorders for use during anesthesia or ventilation support.
  • [0004]
    2. Description of the Related Art
  • [0005]
    Masks such as shown in U.S. Pat. No. 5,243,971 for applying a positive pressure to patients with apnea and other breathing disorders have been developed. These masks provide seals for preventing air from escaping from the mask at the junction of the mask and face. Other types of masks for gas delivery to a patient are also in common use.
  • [0006]
    Measuring air flows to a patient has been accomplished by metering sensors in the air supply connected to the mask as in U.S. Pat. No. 5,503,146 or by belts around the patients chest to measure his breathing as in U.S. Pat. No. 5,131,399.
  • [0007]
    Some devices such as in U.S. Pat. No. 5,507,716 provide sensors combined with sleep masks for covering the eyes of a patient. However there is no known example of sensors built into breathing masks for monitoring or studying patients with breathing disorders.
  • [0008]
    Currently if a patient is to be carefully monitored a plurality of electrodes or sensors would have to be individually applied to the patient and wired to recording equipment. The plurality of sensors and tangle of ensuing wires impede the usage of such monitoring equipment. Sensors providing useful information include Electro-encephalogram (EEG), electromyography (EMG), electro-oculogram (EOG), electro-cardiogram (ECG), Pulse Transit Time (PTT), gas flow sensors, temperature sensors, microphones, blood oxygen meters, blood pressure sensors, pulse sensors, patient movement, position, light, activity sensors, mask leakage, mask pressure, eye movement by polyvinylidene flouride-(PVD) or Piezo, and other means of gathering data about the patient or his environment.
  • [0009]
    It is very inconvenient for the patient and the health care worker to attach a series of different devices to a patient to monitor a plurality of different parameters simultaneously. Therefore a single device for easily measuring a plurality of parameters is desired.
  • SUMMARY OF THE INVENTION
  • [0010]
    The invention relates to providing sensors in breathing masks to make it easy to monitor a patient. The mask has a soft pliable seal material around its perimeter in contact with the patient's face to form a secure seal therewith. Sensors may be recessed into the soft pliable seal material at the surface for contact with the skin of the user when the mask is applied to the user's face. The wiring for the sensors may be inside the soft pliable seal material insulating the wires from damage during use of the mask. Many sensors can be incorporated into the mask. Sensors may be placed on the perimeter or on other portions of the mask not in contact with the skin. Sensors may also be placed on straps or caps used in conjunction with the masks or on other devices used with the mask.
  • [0011]
    Monitoring of patients with sleep disorders, breathing disorders or for anesthesia is made easier and more convenient for the patient and for the health care provider since all the sensors needed are built into a mask which is easily and quickly placed on the patient with all the wiring to the sensors integral with the mask and accessed by a single plug.
  • [0012]
    The types of sensors on or in the mask and straps or caps connected to the mask include but are not limited to oximetery sensors, patient position sensors, eye movement sensors, leak detection sensors, EEG, EMG, EOG, ECG, PTT, microphones, pulse, blood pressure, oxygen saturation, temperature, movement sensors, position sensors, light sensors, leak detection sensors and gas delivery sensors.
  • [0013]
    Connections to outside sources of gases delivered to the mask are by a gas nozzle hook up on the mask. A connection to electrical power and data output cables are by a plug in to a cable connecting to the mask. Alternatively batteries in the mask and telemetry equipment in the mask can provide power and transmission of the data to a microprocessor or computer. For portability the microprocessor can be attached to the mask or be carried by the patient. Similarly a bottle of gas may be connected to the mask and carried by the patient to allow mobility of the patient while wearing the mask.
  • [0014]
    Unique applications for the bio-mask include the capability to apply anesthesia-depth monitoring while administering anesthesia gas to a subject. The ability to monitor the patient non-invasively with the bio-mask while at the same time administering the anesthesia gas to the patient provides a bio-feedback function for immediate and responsive anesthesia depth of the subject. The bio-mask can be used to determine the subject's sleep state by applying standard sleep staging criteria, such as that of R&K rules and/or the application of diagnostic techniques which analyze a number of EEG signals, such as Bispectral Analysis. The invention is unique in its capability to apply such analysis with the minimal-invasive application of a subject breathing mask.
  • [0015]
    R&K rules refer to “A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subject” by Rechtschaffen and Anthony Kales, Editors 1968 which is hereby made a part hereof and incorporated herein by reference.
  • [0016]
    Another unique application for the bio-mask includes the combination of the bio-mask with a cardiac pacemaker. It is envisioned that the gas delivery to the bio-mask may be controlled, in part, via communication from a pacemaker to a bio-mask controller.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0017]
    [0017]FIG. 1 shows a schematic view of the zones for sensors on the inside surface of a soft pliable material on the perimeter of the breathing mask.
  • [0018]
    [0018]FIG. 2 shows a view of the sensors and wiring inside the soft pliable material on the perimeter of the breathing mask.
  • [0019]
    [0019]FIG. 3 shows a side schematic view of the sensors and the wiring inside of the soft pliable material on the perimeter of the breathing mask.
  • [0020]
    [0020]FIG. 4 shows a side schematic view of the straps connected to the mask with sensors embedded in the straps and the mask.
  • [0021]
    [0021]FIG. 5 shows a schematic view of the sensor zones on the perimeter of the breathing mask.
  • [0022]
    [0022]FIG. 6 shows a schematic view of the sensors on the inside surface of a breathing mask.
  • [0023]
    [0023]FIG. 7 shows a side schematic view of the mask with sensors on the surface of the mask.
  • [0024]
    [0024]FIG. 7 shows a side schematic view of the mask with sensors on the surface of the mask.
  • [0025]
    [0025]FIG. 8 shows a front elevated view of one embodiment of the subject invention.
  • [0026]
    [0026]FIG. 9 shows a rear elevated view of the embodiment of FIG. 8.
  • [0027]
    [0027]FIG. 10 shows a side elevated view of the embodiment of FIG. 8.
  • [0028]
    [0028]FIG. 11 shows an exploded view of one embodiment of the subject invention.
  • DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • [0029]
    [0029]FIG. 1 shows the inside of mask 10 including the perimeter surface 12 which contacts the patient's face. The perimeter surface 12 has a plurality of zones 20. Each zone 20 having a sensor 25 in a recess 29 for measuring a parameter of the patient to be monitored or other data such as gas leakage. Other sensors 26 are on the mask 10 but not in contact with the patient's skin. These sensors 26 measure patient data or related data such as ambient light, gas pressure in the mask or ambient temperature.
  • [0030]
    The mask 10 has a gas connector 14 for connecting a hose 32 to provide a gas to the mask 10 and a mask interface connector 16 for plugging in a cable 30 for a power supply and for data transmission
  • [0031]
    In some embodiments of the invention the sensors 25 do not require an outside source of power as the sensors such as heat sensors and light sensors generate current.
  • [0032]
    The mask perimeter surface 12 is preferably made out of a soft pliable material such as silicone rubber for making a good sealing contact with the face of the patient to prevent gas leakage. The material should be soft and pliable enough to follow the contours of the face. The perimeter surface preferably has recesses 29 on the surface for the insertion of sensors 25 so that the sensors can make contact with the patient's skin when the mask is pressed against the patient's face.
  • [0033]
    As seen in FIG. 3 a sensor or electrode 25 attachment to the mask 10 preferably utilizes a rubber compound 28 such as silicon or other medical grade type rubber embedded with carbon or other conductive materials for electrical contact of skin to the mask. As shown in FIG. 2 the recesses 29 are large enough to accommodate electrical connections to leads 27 which are buried in the soft pliable material under the perimeter surface 12. The leads 27 are thus protected from damage and electrically insulated. Preferably the sensors 25 will plug into the leads 27 or printed circuits in the recesses 29. The leads 27 are preferably on printed circuits embedded in the mask or fine wires embedded in the mask and connect the sensors 25 to the mask interface connector 16.
  • [0034]
    [0034]FIG. 5 shows conductive material 40 on the surface in zones 20, such as carbon embedded silicon, can be used on the surface of the perimeter 12 of mask 10 in separate zones 20 to conduct the electrical surface energy from the patient's face. The conductive material 40 is preferably moisture activated to improve electrical conductivity when in contact with the skin. The conductive material 40 may be utilized for some or all electrode 25 contacts in the zones. Alternatively electrodes 25 may directly contact the patient's face. The electrodes may also be inside of the soft pliable material on the perimeter 12 of the mask 10.
  • [0035]
    [0035]FIG. 4 shows a side view of the mask 10 and straps 35 used to keep the mask in place on a patient. The straps 35 have sensors 25 connected to leads 27, which connect the sensors to the mask interface connector 16 and to cable 30 for transmitting data to a computer or other device. The sensors 25 in the straps 35 may be electro-encephalogram EEG sensors for measuring brain waves. The straps 35 may be replaced with a cap having sensors therein. Alternatively a chin strap 37 may be used having sensors 25.
  • [0036]
    [0036]FIG. 5 shows an example of the types of sensors 25 used in zones 20 around the perimeter of the mask 10. Physiological signals from a patient's skin potential are detected by sensors in the zones 20 around perimeter 12 of mask 10. Conductive electrode paste 40 may be used to improve the electrical contact between the sensors 25 and the surface of the skin. The conductive paste 40 can assist in reducing the impedance between the face and the electrical output from the sensors 25 in zones 20. The conductive paste 40 may also assist in preventing gas leaks.
  • [0037]
    As an example of a mask sensor layout the following sensors and their functions are described. However many other types of sensors and arrangements of the sensors are possible.
  • [0038]
    Zone 50 is an electro-oculogram (EOG) to obtain electrical eye movement reference signals from over the bridge of the nose.
  • [0039]
    Zone 51 is an EOG to detect electrical eye movement signals for the inner left eye and zone 61 is designated for electrical eye movement signals for the inner right eye. Eye movement data is related to stages of sleep such as rapid eye movement REM, which indicates a deep sleep state and dreaming.
  • [0040]
    Zone 52 is designated for an EOG to detect electrical eye movement signals for the outer left eye and zone 62 is designated for electrical eye movement signals for the outer right eye.
  • [0041]
    Zone 53 is designated for electro-myography (EMG) to detect electrical signals from muscle contractions in the upper left chin. Zone 63 is correspondingly for the upper right chin. Zones 54 and 64 are for the lower left and lower right chin respectively. The amplitude of the chin signals is proportional to the relaxation state and subsequent sleep state of the patient.
  • [0042]
    Zone 55 is the EMG for the upper left lip, giving information about sleep stages. It is proportional to the relaxation and sleep states of the patient. Zone 65 is the EMG for the upper right lip.
  • [0043]
    Zone 56 is the EMG for the left nasal inner mask it also provides signals for the lip movements and is proportional to the relaxation and sleep states of the patient. Similarly zone 66 is for the right nasal inner mask EMG.
  • [0044]
    Zones 57 and 67 are for the oral left and oral right outer mask EMG signals which are also proportional to the relaxation and sleep states of the patient.
  • [0045]
    Zone 70 is for pressure sensor ports for airflow determination.
  • [0046]
    Microphone 80 on the mask detects the patient's breathing or snoring sounds.
  • [0047]
    [0047]FIG. 6 shows an alternate embodiment where two sensors 58 and 68 are used to find the patient's electrocardiogram ECG. This data is also useful for monitoring a patient. The patient's heart functions provide a lot of useful data about the patient's condition. Pulse Transit Time (PTT) is the time it takes ECG pulses to travel from the heart to a sensor such as a sensor placed on the head, on a finger tip, or on the ear. PTT sensors can be in the mask, on sensors connected to the mask, or sensors used in conjunction with the mask. PTT measurements are used to determine patient arousal and qualitative blood pressure variation.
  • [0048]
    Thermal sensor 81 is used on the inside surface of the mask to detect nasal breathing. Thermal sensor 82 is used on the outside surface of the mask to detect oral breathing. The thermal sensitivity of the sensors 81 and 82 on the surface of the mask 10 opposite the nose or mouth indicates if the patient is breathing through his nose or mouth. The thermal sensors 81, 82 may alternatively be placed on the inside of the mask 10, on the outside of the mask 10, or inside of the material of mask 10 for detecting breathing. The thermal sensors 81, 82 may be a thermistor material, a thermocouple material or any other temperature sensitive material. The thermal sensors 81, 82 may be coatings on the inside of the mask, the outside of the mask or in the mask. The thermal sensors 81, 82 detect heat, which is proportional to the amount of breathing.
  • [0049]
    It is important to detect oral breathing for undetected or partially undetected oral breathing effects the integrity of the patient breathing gas breath monitoring and subsequently compromises the ideal gas delivery to the patient. It is important to detect mouth breathing to assist in diagnosis of sleep disordered breathing. Further, control of a mask nasal ventilation is effected by mouth breathing.
  • [0050]
    A pressure sensor 84 measures the pressure inside of the mask to indicate if there is positive pressure inside the mask. A pressure drop may indicate a leak.
  • [0051]
    A surface reflective oximetry sensor 85 on the inside of the mask detects the patient's pulse rate and oxygen saturation.
  • [0052]
    A surface blood pressure sensor 90 on the perimeter 12 of the mask 10 in contact with the patient can be used to monitor the patient's blood pressure.
  • [0053]
    A thermistor 91 on the perimeter 12 of the mask 10 in contact with the patient can be used to monitor the patient's temperature.
  • [0054]
    A patient recycled air detection system having a sensor 95 on the inside surface of the mask detects the amount expired air from the patient remaining in the mask 10. High levels of expired gas in the mask indicates the mask is not being flushed out and may lead to problems if not enough fresh gas is introduced.
  • [0055]
    A patient back gas occurrence detector 97 in the mask hose connector 14 detects the amount of expired gas in the mask returning with newly delivered gas.
  • [0056]
    [0056]FIG. 7 shows thermal sensors 83 such as thermistors or thermocouples on the inside or outside of the mask adjacent the perimeter 12. These sensors can be attached to a thermally conductive material 92 around the perimeter of the mask 10. Alternatively the thermally conductive material may be on portions of the perimeter. This thermally sensitive material can be on the inside surface of mask 10, the outside surface of mask 10 or embedded within the mask material. Detection of a temperature change by thermal sensors 83 or thermal sensors 83 on thermally conductive material 92 correlates with mask leakage around the perimeter. The thermally sensitive material may be a thermally sensitive material in the mask on the inside of the mask, on the outside of the mask or on the perimeter of the mask. The thermally sensitive material may be a thermistor, a thermocouple, or any other thermally sensitive material.
  • [0057]
    Gases leaking from the mask 10 will cause a temperature change associated with the thermally conductive material 92 and sensors 83 and allow a healthcare specialist real-time monitoring of leak status or post monitoring status of mask leakage. In some instances this can be life saving where a patient's gas delivery is critical and in other cases the leakage incidence can assist in the diagnosis of a patient. This assistance may be in the form of alerting a health care specialist that the gas delivery was subject to leakage and this may affect patient treatment and patient diagnostic conditions. In other instances the gas leakage detection can allow the gas delivery system to automatically compensate for the gas leakage.
  • [0058]
    A light sensitive resistor 86 on the outside surface of the mask 10 indicates the ambient lighting conditions of the patient.
  • [0059]
    Position sensors 87 indicate position or activity of the patient. For example these sensors show if the patient is lying down and is motionless. Such a sensor may be a moving ball across switch contacts, or mercury sensor switches.
  • [0060]
    Body movement sensor 88 can be a PVD or piezo material or micro mechanical to detect the patient's body movements extent and rate to determine a wake versus rest state.
  • [0061]
    All of the above sensors may send data by telemetry rather than by cable 30.
  • [0062]
    All of the above collected data may be used to monitor a patient for a variety of uses including sleep studies, anesthesia and sleep apnea.
  • [0063]
    The data collected can be converted to a serial data stream to allow a single wire to interface all the sensors. The sensors may provide data to adjust gas delivery to the patient.
  • [0064]
    Gain and filtering adjustments to the signals may be used to condition the signals close to source for optimal noise and signal performance.
  • [0065]
    An electrical bias to sensors such as a patient position sensors, thermal conductive zones, microphones, or light dependent resistor may be applied.
  • [0066]
    A computer may process the data or simply store the data to from the monitoring sensors in the mask or straps attached thereto. The monitoring data may be used to diagnose a patient, provide feedback to machines attached to the patient, increase or decrease air supplies to a patient or perform other functions.
  • [0067]
    The mask 10 may be made such that it is a sterile disposable unit for medical use thus lowering costs of treatment by not needing to sterilize masks for new patients and providing a more sterile treatment than reusable masks.
  • [0068]
    In one embodiment, the present invention is utilized to control the delivery of a gas to a patient. An example of EEG data controlling in a bio-feedback application the delivery of gas to a patient may be when a patient has a nasal ventilation device such as a ventilator Continuous Positive Air Pressure (CPAP), Bi-Positive Air Pressure (BPAP), Variable Positive Air Pressure (VPAP), Sleep Linked Positive Air Pressure (SPAP) and the EEG electrodes provide one of the vital signs of if the patient is asleep. Gas is only applied to the mask when the patient is deemed to be asleep. The sensors in the mask 10 are better able to determine when the patient is actually asleep before applying assisted nasal ventilation. Premature application of pressure can prevent the patient from sleeping due to the added discomfort of positive pressure. This function is more sophisticated, sensitive to patient comfort than delay ramp systems commonly used on some ventilation systems.
  • [0069]
    Ventilation devices that use delay ramps do not take into account the patient's sleep state, and so these units are not able to adjust the application of gas to stages of deeper sleep when they are more tolerable to a patient. Furthermore, these units are also not able to adjust the applied pressure to levels which are better tolerated by the patient.
  • [0070]
    As such, the inclusion of a bio feedback mechanism in the delivery of gas significant advantages. As shown in FIGS. 8, 9, and 10, in another embodiment, the present invention is adapted to provide bio-feedback that is utilized to control a gas delivery device. The embodiment is generally comprised of a mask assembly 100 having a body 101 and a forehead support 102 extending from the body. The body is comprised of an internal surface 104, an external surface 106, and a perimeter surface 108. The forehead support 102 extends upwardly from the body and is sized and shaped to contact a patient's forehead. The forehead support 102 includes a forehead support bar 103 adapted to contact a patient's forehead.
  • [0071]
    As shown in FIGS. 11 and 12, in one embodiment, the body 101 includes wings 110 extending from the external surface 106. The wings 110 include an attachment surface 109 serving as a point of attachment to mask straps 111. Conductive carbonized silicon rubber padding 113 are positioned along the strap to detect EEG signals. The external surface 106 also includes a sensor seat 112 wherein a thermistor 114 is detachably connected.
  • [0072]
    In one embodiment, the perimeter surface 108 has cushioning 115 extending therefrom. The cushioning 115 is preferably made a silicon plastic material and is sized and shaped to form an effective seal around a patient's nose. It is also contemplated of shaping the mask to conform to the entire nasal and oral region like general breathing masks. A thermistor coating 116 is placed on the cushioning in order to detect temperature gradient differences indicative of a leak in the mask. The cushioning 115 may also include conductive surfaces 117 to detect physiological signals such as ECG signals. The cushioning 115 provides a comfortable seal around a patient's nose, while reducing the possibility of creating facial sores generally attributed to the metallic sensors used in the prior art.
  • [0073]
    As shown in FIGS. 8, 9, and 11, in one embodiment, the forehead support 102 includes a forehead support bar 103 which extends generally perpendicular to the rest of the forehead support 102. The forehead support bar 103 acts to stabilize the mask 100 on the patient's face and to position sensors along the patient's forehead. A pulse oximetry sensor 118 and EEG sensors 120 are connected to the forehead support bar 103. The forehead support 102 also includes a channel 119 wherein leads from the various sensors travel through.
  • [0074]
    In one embodiment, the EEG sensors 120 includes a conductive carbonized silicone rubber padding 122 which provides cushioning for the forehead support bar and a conductive surface for detecting EEG waves. A support 121 stabilizes contact between a patient's forehead and the EEG sensors 120. The forehead support bar 103 positions the EEG sensors 120 on a patient's forehead just below standard electrode placement positions FP1 used for an EEG channel and FP2 used for a patient ground. The positioning of the EEG sensors on the patients forehead enables the mask to take relevant EEG readings.
  • [0075]
    One or more oximetry sensors or pulse-wave sensors may be positioned on the forehead stabilizer pads 103 of the breathing mask utilized, for example, in nasal positive air pressure systems, patient oxygen therapy, or ventilator breathing masks. Electrophysiological sensors including (but not limited to) sensors enabling the investigation of sleep and breathing-related sleep disorders such as electromyography (EMG), electroencephalography (EEG), electrooculography (EOG) and electrocardiography (ECG), may be embedded in the forehead stabilizer pads 103 of a breathing mask, such as a nasal positive air pressure, patient oxygen therapy, or ventilator breathing mask (but not limited to).
  • [0076]
    This capability can enable the monitoring or derivation of pulse transit time (PTT), PTT-derived arousals, pulse arterial tone (PAT), pulse wave amplitude (PWA), respiratory effort related arousals (RERA)for diagnosis or treatment countermeasure purposes, both in real-time or post monitoring.
  • [0077]
    One or more sensors can be separated with non-conductive barriers between each respective sensor to enable a number of appropriately placed sensors to be positioned within the mask forehead stabilizer pads 103.
  • [0078]
    Electrophysiological sensors including (but not limited to) sensors enabling the investigation of sleep and breathing-related sleep disorders such as electromyography (EMG), electroencephalography (EEG), electrooculography (EOG) and electrocardiography (ECG), embedded in the face seal of the breathing mask, or embedded as (such as but not silicon, rubber, plastic or other flexible material), including carbon impregnated silicon or rubber forming a near perfect seal but containing an effective conductive interface between the breathing mask seal and the subject's face.
  • [0079]
    One or more sensors can be separated with non-conductive barriers between each respective sensor to enable a number of appropriately placed sensors to be positioned within the mask seal perimeter. In this way a means is enabled, for example (but not limited to) for cheek EMG to be detected (with a pair of sensors separated but appropriately located to detect the subjects cheek EMG signal (this signal declines in electrical activity as a subject transitions into deeper stages or sleep, until the lowest cheek EMG activity during REM sleep), EOG (detectable via conductive zones around the upper nose bridge section and near the subjects eyes), EEG (frontal EEG and arousals also detectable from nose or top of mask conductive perimeter zone, for example). Oral breathing detection material including thermally conductive polymer or material (such as but not silicon, rubber, plastic or other flexible material) impregnated or embedded, or attached to inside or particularly outside surface of breathing mask, enabling detection of nasal and or oral (via subject's mouth) breathing, respectively. Detection of oral breathing can be very important with nasal gas delivery such as a nasal positive air pressure, patient oxygen therapy, or ventilator breathing mask (but not limited to) due to the fact that if this breathing goes undetected (as in previous art nasal masks) then the optimal therapy control delivery to the subject is compromised (the device delivering the gas underestimated the actual breathing depth or volume of the subject due to the undetected breathing “leakage” via the mouth.
  • [0080]
    Mask seal leakage detection can be detected by using thermally conductive polymer or material ((such as but not silicon, rubber, plastic or other flexible material) impregnated or embedded, or attached to inside or particularly outside surface of breathing mask face seal. By positioning thermally sensitive material in one or more zones around the face seal it is possible to detect and compute the amount of leakage experienced by the subject receiving gas delivery therapy. The information derived from such “leakage” enables more accurate and precise computation of the therapy devices gas delivery requirements to counter the actual breathing stress, sleep disorders or other health conditions being treated by the gas deliver system. Detection of mask perimeter leakage can be very important with nasal gas delivery such as a nasal positive air pressure, patient oxygen therapy, or ventilator breathing mask (but not limited to) due to the fact that if this breathing goes undetected (as in previous art nasal masks) then the optimal therapy control delivery to the subject is compromised (the device delivering the gas underestimated the actual breathing depth or volume of the subject due to the undetected breathing “leakage” via the mouth.
  • [0081]
    Patient position sensor-breathing can be highly effected by patient position (upright, lying on back, left-side, right side, for example). The integration of a position sensor within the mask can also allow transmission of valuable data for improved gas delivery decision and control.
  • [0082]
    Typically, data sampling for the EEG sensor is set to 16 bit and 512 samples per second. Preferably, unfiltered EEG data received from the EEG sensors 120 are high pass filtered and low pass filtered to 0.15 Hz and 200 Hz, respectively.
  • [0083]
    As shown in FIG. 12, in one embodiment, EMG electrodes 125 are integrated on the mask straps 111. The EMG electrodes 125 are comprised of soft cushions of conductive carbonized silicon rubber. The EMG electrodes are positioned on the mask straps so that when the mask is applied to a patient, the EMG sensors are positioned over the masseter muscle (cheek) and A1, for the EMG channel data and the reference, respectively. The positioning of the EMG electrodes with respect to the patient enables the present invention to monitor muscle activity which are indicative of sleep disorder breathing and of arousal.
  • [0084]
    In one embodiment, the EMG electrodes 125 are data sampled at 512 samples per second. The EMG signals are typically high pass and low pass filtered at 70 Hz and 200 Hz, respectively.
  • [0085]
    The location of the pulse oximetry sensor 118 on the forehead support bar 103 enables the present invention to take accurate oximetry readings using a unique reflective oximetry techniques. The pulse oximetry sensor 118 includes an LED light and a light sensor. The LED beams light through the forehead skin and to the skull. The light bounces of the skull and is reflected back to the light sensor which in turn converts the light into an analog signal. The analog signal is then high pass filtered at about 0.01 Hz and is then analyzed using known pulse oximetric techniques to determine SPO2 levels, a pulse plethysmography waveform, and a heart rate.
  • [0086]
    In one embodiment, the subject mask assembly 100 is in communication with a control system 124 for a gas delivery device. One such control system is described in U.S. Pat. No. 6,397,845 to Burton, the contents of which are hereby incorporated by reference in its entirety. The control system 124 is adapted to determine a sleep state of a patient from the physiological signals which are being detected by the mask assembly 100. The patient's sleep state is then used as a determinate for controlling the delivery of gas to the patient.
  • [0087]
    One of the sleep states detected in U.S. Pat. No. 6,397,845 is the state of arousal. Arousals usually do not cause a person to wake up, but they often transition a patient away from deeper stages of sleep. Furthermore, arousals are often followed by a relatively long period before reentering deeper stages of sleep such as REM or slow-wave. As a result, a person who has numerous arousals may experience fragmented sleep which in turn causes excessive daytime sleepiness or other symptoms.
  • [0088]
    In one embodiment, arousal is determined using Pulse Transit Time (PTT). Studies have shown that sleep disorders such as apnea, hypopnea or upper airway resistance result in an accompanying arousal, and this arousal is accompanied by changes in heart rate, a transient burst of sympathetic activity, and a surge in blood pressure. Obstructive sleep apnea can be correlated with an obvious and measurable increase in intrathoracic pressure associated with obstructive effort and cardiobalistogram effect. The cardiobalistogram effect is created when the lungs apply pressure to the heart. This compresses the heart and reduces the volume of blood pumped by the heart. These cardiovascular changes are recognizable by way of a transient but significant dip in the patient's baseline PTT value.
  • [0089]
    PTT is the time taken for the pulse wave to travel between two arterial sites. The blood pressure is directly proportional to the speed that the arterial pressure wave travels. A rise in blood pressure relates to faster pulse wave and thus shorter PTT. Conversely, a drop in blood pressure results in a slowing of the pulse wave and an increase in PTT.
  • [0090]
    In one embodiment, PTT is obtained directly by utilizing sensors located on the present invention. A detector receives input from the mask and generates a plethysmography waveform. A second detector receives input from the mask and generates an ECG signal. The waveform and the signal are inputted into the controller and a PTT reading is calculated.
  • [0091]
    The PTT is derived by utilizing a plethysmography waveform obtained by using pulse oximetry readings obtained from the pulse oximetry sensor 118 in combination with an ECG signal detected along the perimeter surface 108. The ECG R or Q wave can be used as the start point for the PTT measurement and the end point of the PTT measurement can be the point representing 25% or 50% of the height of the maximum pulse wave value from the pulse oximetry sensor 118.
  • [0092]
    The control system 124 can also be utilized to control delivery of medications and anesthetic agents to a patient. In such a configuration, the control system is typically in communication with a drug dispensing apparatus such as an infusion pump.
  • [0093]
    The matter set forth in the foregoing description and accompanying drawings is offered by way of illustration only and not as a limitation. While a particular embodiment has been shown and described, it will be obvious to those skilled in the art that changes and modifications may be made without departing from the broader aspects of applicants' contribution. The actual scope of the protection sought is intended to be defined in the following claims when viewed in their proper perspective based on the prior art.

Claims (32)

  1. 1. A mask assembly comprising:
    a body having an internal surface, an external surface, and a perimeter surface; and
    a forehead support connected to the body, the forehead support having an EEG sensor located thereon.
  2. 2. The assembly of claim 1, wherein the perimeter surface includes a padding material having a thermosensitive coating.
  3. 3. The assembly of claim 1 wherein the forehead support includes a forehead support bar extending in a generally lateral direction from the forehead support bar.
  4. 4. The assembly of claim 3, and wherein an SPO2 sensor is located on the forehead support bar.
  5. 5. The assembly of claim 4, wherein the EEG sensor includes a pad comprised of a conductive carbonized rubber material.
  6. 6. The assembly of claim 1, and further comprising a strap extending from the mask, and wherein a physiological sensor is located on the strap.
  7. 7. The assembly of claim 1, wherein a portion of the conductive padding is adapted to measure EOG.
  8. 8. A gas delivery system comprising:
    a mask having at least one physiological sensor connected thereto;
    a gas delivery device having an adjustable gas delivery setting; and
    a processor in communication with the gas delivery device and the sensor, the processor adapted to determine the existence of a sleep disorder and to adjust the gas delivery setting based thereon.
  9. 9. The system of claim 8, wherein the sensor is an EMG sensor.
  10. 10. The system of claim 8, wherein the sensor is an ECG sensor.
  11. 11. The system of claim 10, and further comprising a SPO2 sensor connected to the mask.
  12. 12. The system of claim 8, wherein the sensor is an EEG sensor.
  13. 13. The system of claim 8, wherein the processor is also adapted to determine patient arousal.
  14. 14. A gas delivery system comprising:
    a mask having at least one EEG sensor connected thereto;
    a gas delivery device having an adjustable gas delivery setting; and
    a processor in communication with the gas delivery device and the EEG sensor, the processor adapted to determine arousal and to adjust the gas delivery setting based thereon.
  15. 15. The system of claim 14, wherein an SPO2 sensor and an ECG sensor are connected to the mask, and wherein the processor is in communication with both sensors and is adapted to derive a PTT value from an output of each sensor.
  16. 16. The system of claim 14, and further comprising a strap extending from the mask and a plurality of EMG sensors located on the mask and strap, the EMG sensors positioned to detect muscle activity related to sleep state.
  17. 17. A method of delivering gas comprising:
    providing a mask adapted to detect physiological signals and to deliver a gas;
    providing a gas delivery device in fluid communication with the mask and having an adjustable gas output;
    determining a sleep state from physiological signals detected by the mask; and
    adjusting the output from the gas delivery device based on the sleep state.
  18. 18. The method of claim 17, wherein determining a sleep state includes determining arousal.
  19. 19. The method of claim 18, wherein determining arousal includes calculating PTT values from an SPO2 and ECG readings.
  20. 20. The method of claim 18, wherein determining arousal includes analyzing cortical and subcortical EEG signals.
  21. 21. A method of obtaining SPO2 reading from a mask comprising:
    attaching a light source and a light sensor on a mask so that the light source and light sensor are positioned to contact a person's forehead;
    illuminating the light source;
    detecting light from the light source as it deflects from the person's skull; and
    converting the detected light into an analog signal.
  22. 22. The method of claim 21, and further comprising the additional step of high pass filtering the analog signal.
  23. 22. A method of detecting oral or nasal breathing during nasal ventilation, the method comprising:
    providing a mask adapted to form a seal between a patient's nose and mouth, the mask having an interior surface and an exterior surface, the mask also having a first thermal sensor on the interior surface and a second thermal sensor located on the exterior surface to be adjacent the patient's mouth;
    detecting a temperature change in the first or second thermal sensor.
  24. 23. An apparatus comprising:
    a mask having a body position sensor attached thereto;
    a processor in communication with the sensor and adapted to a determine body position from the body position sensor's output.
  25. 24. The apparatus of claim 23, and further comprising movement sensor attached to the mask and in communication with the processor, and wherein the processor is also adapted to determine movement from an output of the movement sensor.
  26. 25. A method of detecting a leak in a breathing mask:
    providing a mask having a perimeter surface with a plurality of thermally conductive surfaces distributed throughout the perimeter surface; and
    detecting a temperature change in any of the plurality of thermally conductive surfaces.
  27. 26. A mask assembly comprising:
    a body having an internal surface, an external surface, and a perimeter surface; and
    a forehead support extending from the body and adapted to contact a forehead surface of a patient during use, the forehead support having a plurality of sensors located thereon for detecting electrophysiological signals of the patient.
  28. 27. The mask assembly of claim 26 wherein the forehead support includes a support pad in contact with the forehead surface.
  29. 28. The mask assembly of claim 26 further comprising:
    a movement sensor for detecting movement of the patient during use.
  30. 29. The mask assembly of claim 26 further comprising:
    a mask seal leakage detector.
  31. 30. A gas delivery system comprising:
    a gas mask adapted to fit on a patient;
    a gas delivery device having an adjustable gas delivery; and
    a processor in communication with the gas delivery device and a cardiac pacemaker, the processor adapted to adjust the gas delivery based on a signal from the cardiac pacemaker.
  32. 31. The gas delivery system of claim 30 wherein the processor receives an additional electrophysiological signal from the patient, and said processor determines the existence of a sleep disorder based upon the signals.
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Cited By (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040015091A1 (en) * 2002-04-01 2004-01-22 Aspect Medical Systems System and method of assessment of arousal, pain and stress during anesthesia and sedation
US20050065449A1 (en) * 2003-09-10 2005-03-24 Caldwell Donald W. Non-contact respiration monitor
US20050085741A1 (en) * 2003-10-17 2005-04-21 Terho Hoskonen Sensor arrangement
US20050145246A1 (en) * 2003-09-18 2005-07-07 Hartley Jesse W. Posture detection system and method
US20060122478A1 (en) * 2004-12-07 2006-06-08 Drager Safety Ag & Co. Kgaa Occupational safety product with contactless measuring electrodes
US20060174883A1 (en) * 2005-02-09 2006-08-10 Acoba, Llc Method and system of leak detection in application of positive airway pressure
US20070208269A1 (en) * 2004-05-18 2007-09-06 Mumford John R Mask assembly, system and method for determining the occurrence of respiratory events using frontal electrode array
US20070215156A1 (en) * 2004-04-15 2007-09-20 Resmed Limited Snoring Treatment Apparatus and Methods of Managing Snorers
WO2007124108A2 (en) * 2006-04-21 2007-11-01 Cardinal Health 205, Inc. Self-contained respiratory therapy apparatus for enhanced patient compliance and therapeutic efficacy
US20080183083A1 (en) * 2007-01-31 2008-07-31 Markowitz H Toby Systems and methods for monitoring effectiveness of congestive heart failure therapy
US20080185001A1 (en) * 2007-01-31 2008-08-07 Draeger Safety Uk Limited Head-up display unit
US20080192459A1 (en) * 2004-05-17 2008-08-14 Resmed Limited Position Sensitive Illumination System
US20080196715A1 (en) * 2007-02-16 2008-08-21 Nihon Kohden Corporation Nasal mask for carbon dioxide gas measurement
US20080283062A1 (en) * 2007-05-18 2008-11-20 Esposito Jr Anthony J Respiratory Component Measurement System
US20090007918A1 (en) * 2006-02-17 2009-01-08 Resmed Limited Method and Apparatus for Monitoring the Condition of a Patient with Diabetes
US20090054802A1 (en) * 2007-08-22 2009-02-26 National Yang-Ming University Sunglass type sleep detecting and preventing device
US20090095299A1 (en) * 2007-10-11 2009-04-16 Edwin Saldivar Sleep inducing apparatus for a CPAP machine
US7591265B2 (en) * 2003-09-18 2009-09-22 Cardiac Pacemakers, Inc. Coordinated use of respiratory and cardiac therapies for sleep disordered breathing
US20090240126A1 (en) * 2008-03-24 2009-09-24 Nellcor Puritan Bennett Llc Method And System For Classification of Photo-Plethysmographically Detected Respiratory Effort
US20090241951A1 (en) * 2008-03-31 2009-10-01 Nellcor Puritan Bennett Llc Leak-compensated pressure triggering in medical ventilators
US20090260630A1 (en) * 2007-10-11 2009-10-22 Edwin Saldivar Sleep inducing apparatus for CPAP machine
US20100081904A1 (en) * 2008-09-30 2010-04-01 Nellcor Puritan Bennett Llc Device And Method For Securing A Medical Sensor to An Infant's Head
US7698909B2 (en) 2002-10-01 2010-04-20 Nellcor Puritan Bennett Llc Headband with tension indicator
US20100168599A1 (en) * 2008-05-13 2010-07-01 Koninklijke Philips Electronics N.V. Respiratory component measurement system with indicating elements
US20100170513A1 (en) * 2009-01-08 2010-07-08 Bowditch Nathaniel L Self-contained, intermittent positive airway pressure systems and methods for treating sleep apnea, snoring, and other respiratory disorders
US7758503B2 (en) 1997-01-27 2010-07-20 Lynn Lawrence A Microprocessor system for the analysis of physiologic and financial datasets
US7757690B2 (en) 2003-09-18 2010-07-20 Cardiac Pacemakers, Inc. System and method for moderating a therapy delivered during sleep using physiologic data acquired during non-sleep
US20100186747A1 (en) * 2007-07-20 2010-07-29 Boehringer Ingelheim International Gmbh Seal testing device
US7787946B2 (en) 2003-08-18 2010-08-31 Cardiac Pacemakers, Inc. Patient monitoring, diagnosis, and/or therapy systems and methods
US20100240982A1 (en) * 2009-03-17 2010-09-23 Advanced Brain Monitoring, Inc. System for the Assessment of Sleep Quality in Adults and Children
US7809420B2 (en) 2003-06-25 2010-10-05 Nellcor Puritan Bennett Llc Hat-based oximeter sensor
US7810359B2 (en) 2002-10-01 2010-10-12 Nellcor Puritan Bennett Llc Headband with tension indicator
US7887493B2 (en) 2003-09-18 2011-02-15 Cardiac Pacemakers, Inc. Implantable device employing movement sensing for detecting sleep-related disorders
WO2011051837A1 (en) 2009-10-28 2011-05-05 Koninklijke Philips Electronics N.V. Pressure support system with inductive tubing
US20110112382A1 (en) * 2009-11-12 2011-05-12 Nellcor Puritan Bennett Llc Systems and methods for combined physiological sensors
US7942824B1 (en) * 2005-11-04 2011-05-17 Cleveland Medical Devices Inc. Integrated sleep diagnostic and therapeutic system and method
US20110196251A1 (en) * 2010-02-10 2011-08-11 Nellcor Puritan Bennett Llc Leak determination in a breathing assistance system
US8002553B2 (en) 2003-08-18 2011-08-23 Cardiac Pacemakers, Inc. Sleep quality data collection and evaluation
US20110270085A1 (en) * 2010-04-30 2011-11-03 Centers For Disease Control And Prevention Ultrasonic in situ respiratory mask testing process and mask
US8068890B2 (en) 2006-09-29 2011-11-29 Nellcor Puritan Bennett Llc Pulse oximetry sensor switchover
US8172766B1 (en) * 2005-11-04 2012-05-08 Cleveland Medical Devices Inc. Integrated sleep diagnosis and treatment device and method
US8221327B2 (en) 2003-09-18 2012-07-17 Cardiac Pacemakers, Inc. Therapy control based on cardiopulmonary status
US20120209355A1 (en) * 2008-12-30 2012-08-16 Koninklijke Philips Electronics N.V. System and method for administering light therapy
WO2012106775A1 (en) * 2011-02-11 2012-08-16 Resmed Limited Method and apparatus for treatment of sleep disorders
US8251061B2 (en) 2003-09-18 2012-08-28 Cardiac Pacemakers, Inc. Methods and systems for control of gas therapy
US8257274B2 (en) 2008-09-25 2012-09-04 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US8267085B2 (en) 2009-03-20 2012-09-18 Nellcor Puritan Bennett Llc Leak-compensated proportional assist ventilation
US20120240933A1 (en) * 2009-12-19 2012-09-27 Koninklijke Philips Electronics N.V. Pressure support system with mask fit feedback display
US8321022B2 (en) 2003-08-18 2012-11-27 Cardiac Pacemakers, Inc. Adaptive therapy for disordered breathing
US8327846B2 (en) 2011-02-08 2012-12-11 Hancock Medical, Inc. Positive airway pressure system with head position control
US8364220B2 (en) 2008-09-25 2013-01-29 Covidien Lp Medical sensor and technique for using the same
CN102974020A (en) * 2012-12-25 2013-03-20 苏州凯迪泰医学科技有限公司 Forehead cushion provided with blood oxygen detection device and breathing mask
US8412297B2 (en) 2003-10-01 2013-04-02 Covidien Lp Forehead sensor placement
US8418691B2 (en) 2009-03-20 2013-04-16 Covidien Lp Leak-compensated pressure regulated volume control ventilation
US8424521B2 (en) 2009-02-27 2013-04-23 Covidien Lp Leak-compensated respiratory mechanics estimation in medical ventilators
US8439031B1 (en) * 2005-07-07 2013-05-14 Ric Investments, Llc Patient treatment system with a patient interface mounted control
US20130180523A1 (en) * 2010-09-03 2013-07-18 Qinetiq Limited Respiratory protection equipment
US8515515B2 (en) 2009-03-25 2013-08-20 Covidien Lp Medical sensor with compressible light barrier and technique for using the same
US20130237793A1 (en) * 2010-11-23 2013-09-12 Resmed Limited Method and apparatus for detecting cardiac signals
US8535222B2 (en) 2002-12-04 2013-09-17 Cardiac Pacemakers, Inc. Sleep detection using an adjustable threshold
US8545416B1 (en) * 2005-11-04 2013-10-01 Cleveland Medical Devices Inc. Integrated diagnostic and therapeutic system and method for improving treatment of subject with complex and central sleep apnea
US8606356B2 (en) 2003-09-18 2013-12-10 Cardiac Pacemakers, Inc. Autonomic arousal detection system and method
WO2013183018A1 (en) * 2012-06-08 2013-12-12 Koninklijke Philips N.V. Patient interface with cushion for red mark prevention
US20140005497A1 (en) * 2012-07-02 2014-01-02 Honeywell International Inc. Mask having integrated physiological condition sensors
US8666467B2 (en) 2001-05-17 2014-03-04 Lawrence A. Lynn System and method for SPO2 instability detection and quantification
US20140076318A1 (en) * 2006-09-27 2014-03-20 Resmed Limited Method and apparatus for assessing sleep quality
US8728001B2 (en) 2006-02-10 2014-05-20 Lawrence A. Lynn Nasal capnographic pressure monitoring system
US8746248B2 (en) 2008-03-31 2014-06-10 Covidien Lp Determination of patient circuit disconnect in leak-compensated ventilatory support
US8781548B2 (en) 2009-03-31 2014-07-15 Covidien Lp Medical sensor with flexible components and technique for using the same
US20140202455A1 (en) * 2011-08-25 2014-07-24 Koninklijke Philips N.V. Method and apparatus for controlling a ventilation therapy device
WO2014117179A1 (en) * 2013-01-28 2014-07-31 Hancock Medical, Inc. Position control devices and methods for use with positive airway pressure systems
US8803682B2 (en) 2010-12-07 2014-08-12 J.T. Labs Limited Sleep-posture sensing and monitoring system
US8862196B2 (en) 2001-05-17 2014-10-14 Lawrence A. Lynn System and method for automatic detection of a plurality of SP02 time series pattern types
US8932227B2 (en) 2000-07-28 2015-01-13 Lawrence A. Lynn System and method for CO2 and oximetry integration
US20150027442A1 (en) * 2013-07-23 2015-01-29 Lockheed Martin Corporation Respiratory Gas Monitoring
WO2015021064A1 (en) * 2013-08-05 2015-02-12 Mannkind Corporation Insufflation apparatus and methods
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US9016147B2 (en) 2009-11-03 2015-04-28 Mannkind Corporation Apparatus and method for simulating inhalation efforts
US9031793B2 (en) 2001-05-17 2015-05-12 Lawrence A. Lynn Centralized hospital monitoring system for automatically detecting upper airway instability and for preventing and aborting adverse drug reactions
US9041925B2 (en) 2009-03-18 2015-05-26 Mannkind Corporation Laser diffraction with inhaler enclosed in positive pressure chamber
US9042952B2 (en) 1997-01-27 2015-05-26 Lawrence A. Lynn System and method for automatic detection of a plurality of SPO2 time series pattern types
US9053222B2 (en) 2002-05-17 2015-06-09 Lawrence A. Lynn Patient safety processor
US9061111B2 (en) 1999-07-23 2015-06-23 Mannkind Corporation Unit dose capsules and dry powder inhaler
US9089497B2 (en) 2005-09-14 2015-07-28 Mannkind Corporation Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
US20150224275A1 (en) * 2012-08-09 2015-08-13 Sander Theodoor Pastoor Customisation or adjustment of patient interfaces
WO2015128173A1 (en) * 2014-02-26 2015-09-03 Koninklijke Philips N.V. Patient interface with automatic position adjustment
US9155493B2 (en) 2008-10-03 2015-10-13 Nellcor Puritan Bennett Ireland Methods and apparatus for calibrating respiratory effort from photoplethysmograph signals
US9192675B2 (en) 2008-06-13 2015-11-24 Mankind Corporation Dry powder inhaler and system for drug delivery
US9220687B2 (en) 2008-12-29 2015-12-29 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9233159B2 (en) 2011-10-24 2016-01-12 Mannkind Corporation Methods and compositions for treating pain
US9241903B2 (en) 2006-02-22 2016-01-26 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
US20160045161A1 (en) * 2013-01-14 2016-02-18 University Health Network Mask and method for breathing disorder identification, characterization and/or diagnosis
USD757244S1 (en) * 2015-02-27 2016-05-24 Sls Medical Technology Corp. Ltd. Sensor for respirator mask
US9364436B2 (en) 2011-06-17 2016-06-14 Mannkind Corporation High capacity diketopiperazine microparticles and methods
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
WO2016154067A1 (en) * 2015-03-20 2016-09-29 Bohnas LLC Breathing detection apparatus
US9468378B2 (en) 1997-01-27 2016-10-18 Lawrence A. Lynn Airway instability detection system and method
US9498589B2 (en) 2011-12-31 2016-11-22 Covidien Lp Methods and systems for adaptive base flow and leak compensation
US9521971B2 (en) 1997-07-14 2016-12-20 Lawrence A. Lynn System and method for automatic detection of a plurality of SPO2 time series pattern types
USD776802S1 (en) 2015-03-06 2017-01-17 Hancock Medical, Inc. Positive airway pressure system console
US9630930B2 (en) 2009-06-12 2017-04-25 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
US9662461B2 (en) 2008-06-13 2017-05-30 Mannkind Corporation Dry powder drug delivery system and methods
US9675771B2 (en) 2013-10-18 2017-06-13 Covidien Lp Methods and systems for leak estimation
US9675674B2 (en) 2004-08-23 2017-06-13 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US20170188856A1 (en) * 2016-01-05 2017-07-06 Tosense, Inc. Floormat physiological sensor
US9700690B2 (en) 2002-03-20 2017-07-11 Mannkind Corporation Inhalation apparatus
US20170203069A1 (en) * 2014-10-02 2017-07-20 Koninklijke Philips N.V. Cushion element for a patient interface
US9796688B2 (en) 2004-08-20 2017-10-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
US9814426B2 (en) 2012-06-14 2017-11-14 Medibotics Llc Mobile wearable electromagnetic brain activity monitor
US9814429B2 (en) 2003-09-18 2017-11-14 Cardiac Pacemakers, Inc. System and method for discrimination of central and obstructive disordered breathing events
US9814856B2 (en) 2004-08-20 2017-11-14 Fisher & Paykel Healthcare Limited Apparatus for measuring properties of gases supplied to a patient
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
US9943571B2 (en) 2008-08-11 2018-04-17 Mannkind Corporation Use of ultrarapid acting insulin

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7204250B1 (en) * 1999-12-16 2007-04-17 Compumedics Limited Bio-mask
GB9929745D0 (en) * 1999-12-17 2000-02-09 Secr Defence Determining the efficiency of respirators and protective clothing and other improvements
CN1466435A (en) * 2000-08-25 2004-01-07 哈里・路易斯・帕兰特 System for physiological monitoring during sleep
GB0115528D0 (en) 2001-06-26 2001-08-15 Really Smart Ideas Ltd Respiration monitoring equipment
DE10139881B4 (en) * 2001-08-20 2017-06-08 Resmed R&D Germany Gmbh Apparatus for supplying a respiratory gas and method for controlling the same
JP2005534383A (en) * 2002-08-05 2005-11-17 レスメッド・リミテッドResmed Limited Inextensible headgear and cpap or ventilator mask having these
DE10245772A1 (en) * 2002-09-26 2004-04-08 Jostra Ag Apparatus and method to establish an artificial circulation isolated in a target area of ​​a human or animal body
GB2394166B (en) * 2002-10-14 2006-01-18 Acoustics Acquisitionco Ltd Cushions
CN101837156B (en) * 2002-11-08 2012-07-04 雷斯梅德有限公司 Headgear assembly for a respiratory mask assembly
US6941182B2 (en) * 2002-11-26 2005-09-06 Resmed Limited Method and apparatus for measurement of pressure at a device/body interface
US7717112B2 (en) * 2003-06-04 2010-05-18 Jianguo Sun Positive airway pressure therapy management module
US6988994B2 (en) * 2003-08-14 2006-01-24 New York University Positive airway pressure system and method for treatment of sleeping disorder in patient
US7896812B2 (en) * 2003-08-14 2011-03-01 New York University System and method for diagnosis and treatment of a breathing pattern of a patient
US7364547B2 (en) * 2003-09-18 2008-04-29 Cardiac Pacemakers, Inc. Use of external respiratory therapy device to detect cardiac electrical activity
US8826909B2 (en) * 2007-06-01 2014-09-09 Ramses Nashed Respiratory face mask and headstrap assembly
US7878198B2 (en) 2004-03-31 2011-02-01 Michael Farrell Methods and apparatus for monitoring the cardiovascular condition of patients with sleep disordered breathing
WO2005096729A2 (en) * 2004-03-31 2005-10-20 Resmed Limited Methods and apparatus for monitoring the cardiovascular condition of patients with sleep disordered breathing
US20060258930A1 (en) * 2004-05-18 2006-11-16 Jianping Wu Device for use in sleep stage determination using frontal electrodes
US20090105577A1 (en) * 2006-05-18 2009-04-23 Jianping Wu Device For Detecting Electrical Potentials Using Frontal Electrodes
US7575005B2 (en) * 2004-05-18 2009-08-18 Excel-Tech Ltd. Mask assembly with integrated sensors
EP1753495B1 (en) 2004-06-03 2010-09-08 Compumedics Limited Adaptable breathing mask
DE102005013429A1 (en) 2005-03-21 2006-09-28 Flore, Ingo, Dr. Mobile diagnostic device
US8528551B2 (en) * 2005-06-14 2013-09-10 Resmed Limited Acclimatization therapy for first time users
US7483731B2 (en) 2005-09-30 2009-01-27 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
WO2007051230A1 (en) * 2005-10-31 2007-05-10 Resmed Ltd Sensing cuff for breathing apparatus
US20090199857A1 (en) * 2006-03-01 2009-08-13 Resmed Limited Method and Apparatus for Reminding user to Replace and/or Service Cpap Apparatus and/or Component Thereof
FR2900813A1 (en) * 2006-05-09 2007-11-16 Alcatel Sa Parameter monitoring system for use in case of chronic obstructive lung disease, has comparison unit comparing measured value with theoretical value of parameter, and communication unit transmitting to remote terminal, message of alarm
JP4892725B2 (en) * 2006-05-25 2012-03-07 国立大学法人 東京医科歯科大学 Inhalation gas supply system
CA2998247A1 (en) * 2006-07-14 2008-01-17 Fisher & Paykel Healthcare Limited Breathing assistance apparatus
CN100574702C (en) 2006-08-02 2009-12-30 周常安 Respiration sensor and method of manufacturing the same
WO2008070148A9 (en) * 2006-12-05 2008-07-31 Axon Sleep Res Lab Inc Pressure support device with dry electrode sleep staging device
CA2969849A1 (en) * 2007-03-27 2008-10-02 Dignity Health Urgent eeg net with transmission capabilities
EP2594303B1 (en) 2007-08-17 2016-11-02 ResMed Limited Apparatus for pressure therapy in the treatment of sleep disordered breathing
JP5263765B2 (en) * 2007-11-22 2013-08-14 国立大学法人 長崎大学 Airway devices
EP2271255B1 (en) * 2008-03-17 2012-10-10 Med Storm Innovation AS Method and apparatus for monitoring the autonomous nervous system of a sedated patient
RU2378984C2 (en) * 2008-03-31 2010-01-20 Закрытое Акционерное Общество "Поликониус-Центр" Device for control and evaluation of physiological processes
WO2009144598A1 (en) * 2008-04-14 2009-12-03 Itamar Medical Ltd. Non-invasive method and apparatus for determining light- sleep and deep-sleep stages
CN101618247B (en) * 2008-07-03 2012-05-16 周常安 Expansible gas delivery system
US20100056941A1 (en) 2008-08-22 2010-03-04 Dymedix Corporation Device controller and datalogger for a closed loop neuromodulator
DE112009002132T5 (en) * 2008-09-01 2011-07-07 Elcam Medical Agricultural Cooperative Association Ltd. Wireless medical monitoring system
US20100069772A1 (en) * 2008-09-12 2010-03-18 Dymedix Corporation Wireless pyro/piezo sensor transceiver
US9949667B2 (en) 2008-11-17 2018-04-24 University Health Network Mask and method for use in respiratory monitoring and diagnostics
DE102008063863A1 (en) * 2008-12-19 2010-07-01 Martin Schneider Electronic component with accommodated electronic component
RU2544466C2 (en) * 2009-06-09 2015-03-20 Конинклейке Филипс Электроникс Н.В. Interface device carrying one or more sensors identifying variables related to fluid flow delivered through device
US20110000481A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Nebulizer for infants and respiratory compromised patients
US20120277548A1 (en) * 2009-08-14 2012-11-01 David Burton Anaesthesia and consciousness depth monitoring system
US20110087084A1 (en) * 2009-10-09 2011-04-14 Electronics And Telecommunications Research Institute Face mask type vital signs measuring apparatus and vital signs management system using the same
JP5727500B2 (en) * 2009-11-11 2015-06-03 コーニンクレッカ フィリップス エヌ ヴェ RFID components of pressure support system
WO2011080641A3 (en) * 2009-12-28 2011-08-25 Koninklijke Philips Electronics N.V. Respiratory mask having means for sampling gas from the airway of the patient
EP2523719A4 (en) * 2010-01-13 2015-09-02 Borody Thomas J A mask for use with a patient undergoing a sedated endoscopic procedure
US9339626B2 (en) 2010-03-16 2016-05-17 Carefusion 207, Inc. Seal for variable compression interfaces
WO2012058727A3 (en) * 2010-11-05 2012-08-30 Resmed Limited Acoustic detection mask systems and/or methods
JP2014518645A (en) * 2011-03-23 2014-08-07 コーニンクレッカ フィリップス エヌ ヴェ Pulse oximetry in respiratory therapy patient interface
JP6019559B2 (en) * 2011-10-12 2016-11-02 ソニー株式会社 Psg inspection equipment
US20130186405A1 (en) * 2012-01-25 2013-07-25 Openpeak Inc. System and method for monitoring medical equipment
CN103648567B (en) * 2012-03-09 2016-11-23 汉考克医药公司 A head position control of the positive pressure ventilation system
US20130255677A1 (en) * 2012-03-30 2013-10-03 Christopher M. Varga Disposable respiratory circuit coupled with a disposable temperature sensor
US20140000615A1 (en) * 2012-06-27 2014-01-02 Alan Wanderer System for reduction of air leaks with use of cpap masks
JP6184486B2 (en) * 2012-07-03 2017-08-23 コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. Fixed control for the patient interface
EP2895225B1 (en) * 2012-09-14 2017-11-08 Fisher & Paykel Healthcare Limited External sensor arrangement for patient interface
RU2516388C2 (en) * 2012-09-14 2014-05-20 Борис Лаврович Макеев Respiratory rate meter
CN102944371B (en) * 2012-11-06 2016-01-06 北京航空航天大学 A non-invasive ventilation interface detection system
NL1039894C (en) * 2012-11-13 2014-05-14 Cpg Medical B V Breathing assistance system.
FR3002850B1 (en) * 2013-03-05 2018-01-12 Philippe Goutorbe Device comprising a sensor of the saturation in pulsed oxygen
EP3001818A4 (en) * 2013-07-03 2017-03-01 Astartein Llc Devices, systems and methods for facilitating facemask compliance
JP6006903B2 (en) * 2013-08-12 2016-10-12 コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. Detection of the fit of the patient interface device
GB2525643B (en) * 2014-05-01 2016-10-05 Univ Cape Town Method and device to monitor infectious patients
WO2015196255A1 (en) * 2014-06-27 2015-12-30 Resmed Limited Auto-fit mask
CN205626668U (en) * 2015-02-25 2016-10-12 台中荣民总医院 Induction type respirator and breathing system of looking after thereof
CN104759043B (en) * 2015-04-07 2017-12-26 杨彬 A portable breathing machine intelligence and intelligent control system
EP3097849A1 (en) * 2015-05-26 2016-11-30 Akern S.r.L. Eyeglasses for monitoring one or more physiological parameters of the user that wears them
WO2017040333A1 (en) * 2015-08-28 2017-03-09 Awarables, Inc. Visualizing, scoring, recording, and analyzing sleep data and hypnograms
CN105411601A (en) * 2015-12-31 2016-03-23 北京怡和嘉业医疗科技有限公司 Blood oxygen monitoring device and breathing mask
CN105771054A (en) * 2016-05-05 2016-07-20 武汉大学 System for monitoring air tightness of oxygen mask
CN205795674U (en) * 2016-05-24 2016-12-14 深圳市前海康启源科技有限公司 Portable temperature taking and respiratory frequency's all -in -one
CN106039516A (en) * 2016-06-24 2016-10-26 广州医软智能科技有限公司 Oxygen inhalation face mask for apnea alarm
CN106345028A (en) * 2016-08-31 2017-01-25 林常森 Multi-channel pharynx oralis breathing device for anesthesia department

Citations (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3606881A (en) * 1970-02-20 1971-09-21 Riley D Woodson Conductive rubber electrode
US4875477A (en) * 1987-07-23 1989-10-24 Dragerwerk Aktiengesellschaft Protective mask having a built-in sensor for monitoring vital functions
USH1039H (en) * 1988-11-14 1992-04-07 The United States Of America As Represented By The Secretary Of The Air Force Intrusion-free physiological condition monitoring
US5131399A (en) * 1990-08-06 1992-07-21 Sciarra Michael J Patient monitoring apparatus and method
US5134995A (en) * 1989-05-19 1992-08-04 Puritan-Bennett Corporation Inspiratory airway pressure system with admittance determining apparatus and method
US5199424A (en) * 1987-06-26 1993-04-06 Sullivan Colin E Device for monitoring breathing during sleep and control of CPAP treatment that is patient controlled
US5243146A (en) * 1991-01-29 1993-09-07 Yazaki Corporation Electromagnetic-type load weighing apparatus
US5243971A (en) * 1990-05-21 1993-09-14 The University Of Sydney Nasal mask for CPAP having ballooning/moulding seal with wearer's nose and facial contours
US5293867A (en) * 1992-09-24 1994-03-15 Oommen Kalarickal J Method and apparatus for marking electrode locations for electroencephalographic procedure
US5353793A (en) * 1991-11-25 1994-10-11 Oishi-Kogyo Company Sensor apparatus
US5353788A (en) * 1992-09-21 1994-10-11 Miles Laughton E Cardio-respiratory control and monitoring system for determining CPAP pressure for apnea treatment
US5503147A (en) * 1993-06-09 1996-04-02 Intertechnique Respiratory equipment with comfort adjustment
US5503146A (en) * 1994-10-26 1996-04-02 Devilbiss Health Care, Inc. Standby control for CPAP apparatus
US5507716A (en) * 1991-08-21 1996-04-16 The Lucidity Institute, Inc. Equipment and methods used to induce lucid dreams in sleeping persons
US5584296A (en) * 1992-12-01 1996-12-17 Somanetics Corporation Patient sensor for optical cerebral oximeters and the like
US5673692A (en) * 1995-02-03 1997-10-07 Biosignals Ltd. Co. Single site, multi-variable patient monitor
US5880417A (en) * 1996-02-07 1999-03-09 Lg Industrial Systems Co., Ltd. Synchronous position correction apparatus for elevator
US6000395A (en) * 1998-05-07 1999-12-14 Brown; Norma Avalanche and hyothermia protective system
US6032065A (en) * 1997-07-21 2000-02-29 Nellcor Puritan Bennett Sensor mask and method of making same
US6029665A (en) * 1993-11-05 2000-02-29 Resmed Limited Determination of patency of airway
US6097981A (en) * 1997-04-30 2000-08-01 Unique Logic And Technology, Inc. Electroencephalograph based biofeedback system and method
US6119693A (en) * 1998-01-16 2000-09-19 Resmed Limited Forehead support for facial mask
US6199550B1 (en) * 1998-08-14 2001-03-13 Bioasyst, L.L.C. Integrated physiologic sensor system
US6357440B1 (en) * 1999-06-16 2002-03-19 Mallinckrodt Inc. Pliable respiratory mask
US6385486B1 (en) * 1997-08-07 2002-05-07 New York University Brain function scan system
US6398739B1 (en) * 1987-06-26 2002-06-04 Resmed Limited Device and method for nonclinical monitoring of breathing during sleep, control of CPAP treatment and preventing apnea
US6397845B1 (en) * 1995-10-31 2002-06-04 Compumedics, Ltd. Apparatus for gas delivery
US6532961B1 (en) * 1999-06-18 2003-03-18 Resmed Limited Forehead support for facial mask
US6542081B2 (en) * 1996-08-19 2003-04-01 William C. Torch System and method for monitoring eye movement
US6708051B1 (en) * 1998-11-10 2004-03-16 Compumedics Limited FMRI compatible electrode and electrode placement techniques
US20040144383A1 (en) * 2003-01-28 2004-07-29 Beth Israel Deaconess Medical Center, Inc. Gas systems and methods for enabling respiratory stability
US20050268916A1 (en) * 2004-05-18 2005-12-08 Mumford John R Mask assembly with integrated sensors
US7054680B1 (en) * 1999-05-04 2006-05-30 Map Medizin-Technologie Gmbh Device for detecting electrical potentials in the forehead-area of a patient
US20070208269A1 (en) * 2004-05-18 2007-09-06 Mumford John R Mask assembly, system and method for determining the occurrence of respiratory events using frontal electrode array
US20080092898A1 (en) * 2004-08-27 2008-04-24 John Hopkins University Disposable Sleep And Breathing Monitor
US20080127978A1 (en) * 2006-12-05 2008-06-05 Benjamin Rubin Pressure support system with dry electrode sleep staging device

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411527A (en) * 1989-05-03 1995-05-02 Intermedics, Inc. Difibrillation electrodes and implantation
US5063938A (en) * 1990-11-01 1991-11-12 Beck Donald C Respiration-signalling device
CN2089347U (en) 1991-03-05 1991-11-27 青岛市人民医院 First-aid breathing mask
WO1993002616A1 (en) * 1991-08-09 1993-02-18 Srd Shorashim Medical, Ltd. Apparatus for mounting electrodes
US5435316A (en) * 1993-10-07 1995-07-25 Medtronic, Inc. Low amplitude pacing artifact detection amplifier circuit with driven right leg for filtering high frequency noise caused by multiple noise sources
DE69422900T2 (en) * 1993-12-01 2000-06-08 Resmed Ltd Device for generating a continuous positive airway pressure (CPAP)
GB9422224D0 (en) 1994-11-03 1994-12-21 Brain Archibald Ian Jeremy A laryngeal mask airway device modified to detect and/or stimulate mescle or nerve activity
US5860417A (en) 1995-01-13 1999-01-19 Kettl; Lonnie Joe Microphone mounting structure for a sound amplifying respirator and/or bubble suit
US5617849A (en) * 1995-09-12 1997-04-08 Minnesota Mining And Manufacturing Company Respirator having thermochromic fit-indicating seal
US5857460A (en) 1996-03-14 1999-01-12 Beth Israel Deaconess Medical Center, Inc. Gas-sensing mask
US6171258B1 (en) * 1998-10-08 2001-01-09 Sleep Solutions, Inc. Multi-channel self-contained apparatus and method for diagnosis of sleep disorders
US7204250B1 (en) * 1999-12-16 2007-04-17 Compumedics Limited Bio-mask
USD468421S1 (en) * 2001-09-24 2003-01-07 Resmed Limited Nasal mask
USD468823S1 (en) * 2001-09-25 2003-01-14 Resmed Limited Nasal mask

Patent Citations (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3606881A (en) * 1970-02-20 1971-09-21 Riley D Woodson Conductive rubber electrode
US6635021B1 (en) * 1987-06-26 2003-10-21 Resmed Limited Method and apparatus useful in the diagnosis of obstructive sleep apnea of a patient
US5199424A (en) * 1987-06-26 1993-04-06 Sullivan Colin E Device for monitoring breathing during sleep and control of CPAP treatment that is patient controlled
US6398739B1 (en) * 1987-06-26 2002-06-04 Resmed Limited Device and method for nonclinical monitoring of breathing during sleep, control of CPAP treatment and preventing apnea
US4875477A (en) * 1987-07-23 1989-10-24 Dragerwerk Aktiengesellschaft Protective mask having a built-in sensor for monitoring vital functions
USH1039H (en) * 1988-11-14 1992-04-07 The United States Of America As Represented By The Secretary Of The Air Force Intrusion-free physiological condition monitoring
US5134995A (en) * 1989-05-19 1992-08-04 Puritan-Bennett Corporation Inspiratory airway pressure system with admittance determining apparatus and method
US5243971A (en) * 1990-05-21 1993-09-14 The University Of Sydney Nasal mask for CPAP having ballooning/moulding seal with wearer's nose and facial contours
US5131399A (en) * 1990-08-06 1992-07-21 Sciarra Michael J Patient monitoring apparatus and method
US5243146A (en) * 1991-01-29 1993-09-07 Yazaki Corporation Electromagnetic-type load weighing apparatus
US5507716A (en) * 1991-08-21 1996-04-16 The Lucidity Institute, Inc. Equipment and methods used to induce lucid dreams in sleeping persons
US5353793A (en) * 1991-11-25 1994-10-11 Oishi-Kogyo Company Sensor apparatus
US5353788A (en) * 1992-09-21 1994-10-11 Miles Laughton E Cardio-respiratory control and monitoring system for determining CPAP pressure for apnea treatment
US5293867A (en) * 1992-09-24 1994-03-15 Oommen Kalarickal J Method and apparatus for marking electrode locations for electroencephalographic procedure
US5584296A (en) * 1992-12-01 1996-12-17 Somanetics Corporation Patient sensor for optical cerebral oximeters and the like
US5503147A (en) * 1993-06-09 1996-04-02 Intertechnique Respiratory equipment with comfort adjustment
US6029665A (en) * 1993-11-05 2000-02-29 Resmed Limited Determination of patency of airway
US5503146A (en) * 1994-10-26 1996-04-02 Devilbiss Health Care, Inc. Standby control for CPAP apparatus
US5673692A (en) * 1995-02-03 1997-10-07 Biosignals Ltd. Co. Single site, multi-variable patient monitor
US6397845B1 (en) * 1995-10-31 2002-06-04 Compumedics, Ltd. Apparatus for gas delivery
US5880417A (en) * 1996-02-07 1999-03-09 Lg Industrial Systems Co., Ltd. Synchronous position correction apparatus for elevator
US6542081B2 (en) * 1996-08-19 2003-04-01 William C. Torch System and method for monitoring eye movement
US6097981A (en) * 1997-04-30 2000-08-01 Unique Logic And Technology, Inc. Electroencephalograph based biofeedback system and method
US6032065A (en) * 1997-07-21 2000-02-29 Nellcor Puritan Bennett Sensor mask and method of making same
US6385486B1 (en) * 1997-08-07 2002-05-07 New York University Brain function scan system
US6119693A (en) * 1998-01-16 2000-09-19 Resmed Limited Forehead support for facial mask
US6000395A (en) * 1998-05-07 1999-12-14 Brown; Norma Avalanche and hyothermia protective system
US6199550B1 (en) * 1998-08-14 2001-03-13 Bioasyst, L.L.C. Integrated physiologic sensor system
US6708051B1 (en) * 1998-11-10 2004-03-16 Compumedics Limited FMRI compatible electrode and electrode placement techniques
US7054680B1 (en) * 1999-05-04 2006-05-30 Map Medizin-Technologie Gmbh Device for detecting electrical potentials in the forehead-area of a patient
US6357440B1 (en) * 1999-06-16 2002-03-19 Mallinckrodt Inc. Pliable respiratory mask
US6532961B1 (en) * 1999-06-18 2003-03-18 Resmed Limited Forehead support for facial mask
US20040144383A1 (en) * 2003-01-28 2004-07-29 Beth Israel Deaconess Medical Center, Inc. Gas systems and methods for enabling respiratory stability
US20050268916A1 (en) * 2004-05-18 2005-12-08 Mumford John R Mask assembly with integrated sensors
US20070208269A1 (en) * 2004-05-18 2007-09-06 Mumford John R Mask assembly, system and method for determining the occurrence of respiratory events using frontal electrode array
US20080092898A1 (en) * 2004-08-27 2008-04-24 John Hopkins University Disposable Sleep And Breathing Monitor
US20080127978A1 (en) * 2006-12-05 2008-06-05 Benjamin Rubin Pressure support system with dry electrode sleep staging device

Cited By (187)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8152732B2 (en) 1992-08-19 2012-04-10 Lynn Lawrence A Microprocessor system for the analysis of physiologic and financial datasets
US9468378B2 (en) 1997-01-27 2016-10-18 Lawrence A. Lynn Airway instability detection system and method
US7758503B2 (en) 1997-01-27 2010-07-20 Lynn Lawrence A Microprocessor system for the analysis of physiologic and financial datasets
US8241213B2 (en) 1997-01-27 2012-08-14 Lynn Lawrence A Microprocessor system for the analysis of physiologic datasets
US9042952B2 (en) 1997-01-27 2015-05-26 Lawrence A. Lynn System and method for automatic detection of a plurality of SPO2 time series pattern types
US9521971B2 (en) 1997-07-14 2016-12-20 Lawrence A. Lynn System and method for automatic detection of a plurality of SPO2 time series pattern types
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US9801925B2 (en) 1999-06-29 2017-10-31 Mannkind Corporation Potentiation of glucose elimination
US9061111B2 (en) 1999-07-23 2015-06-23 Mannkind Corporation Unit dose capsules and dry powder inhaler
US8932227B2 (en) 2000-07-28 2015-01-13 Lawrence A. Lynn System and method for CO2 and oximetry integration
US8862196B2 (en) 2001-05-17 2014-10-14 Lawrence A. Lynn System and method for automatic detection of a plurality of SP02 time series pattern types
US9031793B2 (en) 2001-05-17 2015-05-12 Lawrence A. Lynn Centralized hospital monitoring system for automatically detecting upper airway instability and for preventing and aborting adverse drug reactions
US8666467B2 (en) 2001-05-17 2014-03-04 Lawrence A. Lynn System and method for SPO2 instability detection and quantification
US9700690B2 (en) 2002-03-20 2017-07-11 Mannkind Corporation Inhalation apparatus
US20040015091A1 (en) * 2002-04-01 2004-01-22 Aspect Medical Systems System and method of assessment of arousal, pain and stress during anesthesia and sedation
US9053222B2 (en) 2002-05-17 2015-06-09 Lawrence A. Lynn Patient safety processor
US7810359B2 (en) 2002-10-01 2010-10-12 Nellcor Puritan Bennett Llc Headband with tension indicator
US7822453B2 (en) 2002-10-01 2010-10-26 Nellcor Puritan Bennett Llc Forehead sensor placement
US8452367B2 (en) 2002-10-01 2013-05-28 Covidien Lp Forehead sensor placement
US7899509B2 (en) 2002-10-01 2011-03-01 Nellcor Puritan Bennett Llc Forehead sensor placement
US7698909B2 (en) 2002-10-01 2010-04-20 Nellcor Puritan Bennett Llc Headband with tension indicator
US8535222B2 (en) 2002-12-04 2013-09-17 Cardiac Pacemakers, Inc. Sleep detection using an adjustable threshold
US8956295B2 (en) 2002-12-04 2015-02-17 Cardiac Pacemakers, Inc. Sleep detection using an adjustable threshold
US7809420B2 (en) 2003-06-25 2010-10-05 Nellcor Puritan Bennett Llc Hat-based oximeter sensor
US7813779B2 (en) 2003-06-25 2010-10-12 Nellcor Puritan Bennett Llc Hat-based oximeter sensor
US7877127B2 (en) 2003-06-25 2011-01-25 Nellcor Puritan Bennett Llc Hat-based oximeter sensor
US7979102B2 (en) 2003-06-25 2011-07-12 Nellcor Puritan Bennett Llc Hat-based oximeter sensor
US7877126B2 (en) 2003-06-25 2011-01-25 Nellcor Puritan Bennett Llc Hat-based oximeter sensor
US7787946B2 (en) 2003-08-18 2010-08-31 Cardiac Pacemakers, Inc. Patient monitoring, diagnosis, and/or therapy systems and methods
US8321022B2 (en) 2003-08-18 2012-11-27 Cardiac Pacemakers, Inc. Adaptive therapy for disordered breathing
US8915741B2 (en) 2003-08-18 2014-12-23 Cardiac Pacemakers, Inc. Sleep quality data collection and evaluation
US8002553B2 (en) 2003-08-18 2011-08-23 Cardiac Pacemakers, Inc. Sleep quality data collection and evaluation
US20050065449A1 (en) * 2003-09-10 2005-03-24 Caldwell Donald W. Non-contact respiration monitor
US7169112B2 (en) * 2003-09-10 2007-01-30 The United States Of America As Represented By The Secretary Of The Army Non-contact respiration monitor
US7591265B2 (en) * 2003-09-18 2009-09-22 Cardiac Pacemakers, Inc. Coordinated use of respiratory and cardiac therapies for sleep disordered breathing
US8221327B2 (en) 2003-09-18 2012-07-17 Cardiac Pacemakers, Inc. Therapy control based on cardiopulmonary status
US8606356B2 (en) 2003-09-18 2013-12-10 Cardiac Pacemakers, Inc. Autonomic arousal detection system and method
US7757690B2 (en) 2003-09-18 2010-07-20 Cardiac Pacemakers, Inc. System and method for moderating a therapy delivered during sleep using physiologic data acquired during non-sleep
US8657756B2 (en) 2003-09-18 2014-02-25 Cardiac Pacemakers, Inc. Implantable device employing movement sensing for detecting sleep-related disorders
US8522779B2 (en) 2003-09-18 2013-09-03 Cardiac Pacemakers, Inc. Coordinated use of respiratory and cardiac therapies for sleep disordered breathing
US8251061B2 (en) 2003-09-18 2012-08-28 Cardiac Pacemakers, Inc. Methods and systems for control of gas therapy
US9814429B2 (en) 2003-09-18 2017-11-14 Cardiac Pacemakers, Inc. System and method for discrimination of central and obstructive disordered breathing events
US7887493B2 (en) 2003-09-18 2011-02-15 Cardiac Pacemakers, Inc. Implantable device employing movement sensing for detecting sleep-related disorders
US9014819B2 (en) 2003-09-18 2015-04-21 Cardiac Pacemakers, Inc. Autonomic arousal detection system and method
US8104470B2 (en) 2003-09-18 2012-01-31 Cardiac Pacemakers, Inc. Coordinated use of respiratory and cardiac therapies for sleep disordered breathing
US20050145246A1 (en) * 2003-09-18 2005-07-07 Hartley Jesse W. Posture detection system and method
US7664546B2 (en) * 2003-09-18 2010-02-16 Cardiac Pacemakers, Inc. Posture detection system and method
US8412297B2 (en) 2003-10-01 2013-04-02 Covidien Lp Forehead sensor placement
US20050085741A1 (en) * 2003-10-17 2005-04-21 Terho Hoskonen Sensor arrangement
US7496400B2 (en) * 2003-10-17 2009-02-24 Ge Healthcare Finland Oy Sensor arrangement
US20070215156A1 (en) * 2004-04-15 2007-09-20 Resmed Limited Snoring Treatment Apparatus and Methods of Managing Snorers
US9144654B2 (en) * 2004-04-15 2015-09-29 Resmed Limited Snoring treatment apparatus and methods of managing snorers
US8894231B2 (en) * 2004-05-17 2014-11-25 Resmed Limited Position sensitive illumination system
US20080192459A1 (en) * 2004-05-17 2008-08-14 Resmed Limited Position Sensitive Illumination System
US20070208269A1 (en) * 2004-05-18 2007-09-06 Mumford John R Mask assembly, system and method for determining the occurrence of respiratory events using frontal electrode array
US9796688B2 (en) 2004-08-20 2017-10-24 Mannkind Corporation Catalysis of diketopiperazine synthesis
US9814856B2 (en) 2004-08-20 2017-11-14 Fisher & Paykel Healthcare Limited Apparatus for measuring properties of gases supplied to a patient
US9675674B2 (en) 2004-08-23 2017-06-13 Mannkind Corporation Diketopiperazine salts for drug delivery and related methods
US20060122478A1 (en) * 2004-12-07 2006-06-08 Drager Safety Ag & Co. Kgaa Occupational safety product with contactless measuring electrodes
GB2421082A (en) * 2004-12-07 2006-06-14 Draeger Safety Ag & Co Kgaa Protective apparel having contactless physiological sensing electrodes
US20060174883A1 (en) * 2005-02-09 2006-08-10 Acoba, Llc Method and system of leak detection in application of positive airway pressure
US8439031B1 (en) * 2005-07-07 2013-05-14 Ric Investments, Llc Patient treatment system with a patient interface mounted control
US9717689B2 (en) 2005-09-14 2017-08-01 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US9446001B2 (en) 2005-09-14 2016-09-20 Mannkind Corporation Increasing drug affinity for crystalline microparticle surfaces
US9089497B2 (en) 2005-09-14 2015-07-28 Mannkind Corporation Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
US9283193B2 (en) 2005-09-14 2016-03-15 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
US7942824B1 (en) * 2005-11-04 2011-05-17 Cleveland Medical Devices Inc. Integrated sleep diagnostic and therapeutic system and method
US8172766B1 (en) * 2005-11-04 2012-05-08 Cleveland Medical Devices Inc. Integrated sleep diagnosis and treatment device and method
US9533114B1 (en) * 2005-11-04 2017-01-03 Cleveland Medical Devices Inc. Integrated diagnostic and therapeutic system and method for improving treatment of subject with complex and central sleep apnea
US8545416B1 (en) * 2005-11-04 2013-10-01 Cleveland Medical Devices Inc. Integrated diagnostic and therapeutic system and method for improving treatment of subject with complex and central sleep apnea
US8728001B2 (en) 2006-02-10 2014-05-20 Lawrence A. Lynn Nasal capnographic pressure monitoring system
US20090007918A1 (en) * 2006-02-17 2009-01-08 Resmed Limited Method and Apparatus for Monitoring the Condition of a Patient with Diabetes
US8640698B2 (en) * 2006-02-17 2014-02-04 Redmed Limited Method and apparatus for monitoring the condition of a patient with diabetes
US20140144431A1 (en) * 2006-02-17 2014-05-29 Resmed Limited Method and apparatus for monitoring the condition of a patient with diabetes
US9662462B2 (en) * 2006-02-17 2017-05-30 Resmed Limited Method and apparatus for monitoring the condition of a patient with diabetes
US9241903B2 (en) 2006-02-22 2016-01-26 Mannkind Corporation Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
WO2007124108A2 (en) * 2006-04-21 2007-11-01 Cardinal Health 205, Inc. Self-contained respiratory therapy apparatus for enhanced patient compliance and therapeutic efficacy
WO2007124108A3 (en) * 2006-04-21 2008-08-21 Cardinal Health 205 Inc Self-contained respiratory therapy apparatus for enhanced patient compliance and therapeutic efficacy
US20140076318A1 (en) * 2006-09-27 2014-03-20 Resmed Limited Method and apparatus for assessing sleep quality
US8068890B2 (en) 2006-09-29 2011-11-29 Nellcor Puritan Bennett Llc Pulse oximetry sensor switchover
US8082922B2 (en) * 2007-01-31 2011-12-27 Draeger Safety Uk Limited Head-up display unit
US20080185001A1 (en) * 2007-01-31 2008-08-07 Draeger Safety Uk Limited Head-up display unit
US20080183083A1 (en) * 2007-01-31 2008-07-31 Markowitz H Toby Systems and methods for monitoring effectiveness of congestive heart failure therapy
US7841988B2 (en) * 2007-02-16 2010-11-30 Nihon Kohden Corporation Nasal mask for carbon dioxide gas measurement
US20080196715A1 (en) * 2007-02-16 2008-08-21 Nihon Kohden Corporation Nasal mask for carbon dioxide gas measurement
US7927285B2 (en) * 2007-02-16 2011-04-19 Nihon Kohden Corporation Nasal mask for carbon dioxide gas measurement
US20080283062A1 (en) * 2007-05-18 2008-11-20 Esposito Jr Anthony J Respiratory Component Measurement System
US20100186747A1 (en) * 2007-07-20 2010-07-29 Boehringer Ingelheim International Gmbh Seal testing device
US20090054802A1 (en) * 2007-08-22 2009-02-26 National Yang-Ming University Sunglass type sleep detecting and preventing device
US20090095299A1 (en) * 2007-10-11 2009-04-16 Edwin Saldivar Sleep inducing apparatus for a CPAP machine
US20090260630A1 (en) * 2007-10-11 2009-10-22 Edwin Saldivar Sleep inducing apparatus for CPAP machine
US9044558B2 (en) 2008-03-24 2015-06-02 Covidien Lp Method and system for classification of photo-plethysmographically detected respiratory effort
US20090240126A1 (en) * 2008-03-24 2009-09-24 Nellcor Puritan Bennett Llc Method And System For Classification of Photo-Plethysmographically Detected Respiratory Effort
US8365730B2 (en) 2008-03-24 2013-02-05 Covidien Lp Method and system for classification of photo-plethysmographically detected respiratory effort
US8272379B2 (en) 2008-03-31 2012-09-25 Nellcor Puritan Bennett, Llc Leak-compensated flow triggering and cycling in medical ventilators
US8746248B2 (en) 2008-03-31 2014-06-10 Covidien Lp Determination of patient circuit disconnect in leak-compensated ventilatory support
US8272380B2 (en) 2008-03-31 2012-09-25 Nellcor Puritan Bennett, Llc Leak-compensated pressure triggering in medical ventilators
US9421338B2 (en) 2008-03-31 2016-08-23 Covidien Lp Ventilator leak compensation
US20090241951A1 (en) * 2008-03-31 2009-10-01 Nellcor Puritan Bennett Llc Leak-compensated pressure triggering in medical ventilators
US8434480B2 (en) 2008-03-31 2013-05-07 Covidien Lp Ventilator leak compensation
US20100168599A1 (en) * 2008-05-13 2010-07-01 Koninklijke Philips Electronics N.V. Respiratory component measurement system with indicating elements
US9521963B2 (en) * 2008-05-13 2016-12-20 Ric Investments, Llc Respiratory component measurement system with indicating elements
US9511198B2 (en) 2008-06-13 2016-12-06 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9446133B2 (en) 2008-06-13 2016-09-20 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9192675B2 (en) 2008-06-13 2015-11-24 Mankind Corporation Dry powder inhaler and system for drug delivery
US9662461B2 (en) 2008-06-13 2017-05-30 Mannkind Corporation Dry powder drug delivery system and methods
US9339615B2 (en) 2008-06-13 2016-05-17 Mannkind Corporation Dry powder inhaler and system for drug delivery
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
US9943571B2 (en) 2008-08-11 2018-04-17 Mannkind Corporation Use of ultrarapid acting insulin
US8364220B2 (en) 2008-09-25 2013-01-29 Covidien Lp Medical sensor and technique for using the same
US8257274B2 (en) 2008-09-25 2012-09-04 Nellcor Puritan Bennett Llc Medical sensor and technique for using the same
US20100081904A1 (en) * 2008-09-30 2010-04-01 Nellcor Puritan Bennett Llc Device And Method For Securing A Medical Sensor to An Infant's Head
US9155493B2 (en) 2008-10-03 2015-10-13 Nellcor Puritan Bennett Ireland Methods and apparatus for calibrating respiratory effort from photoplethysmograph signals
US9655850B2 (en) 2008-12-29 2017-05-23 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9220687B2 (en) 2008-12-29 2015-12-29 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US9393438B2 (en) * 2008-12-30 2016-07-19 Koninklijke Philips N.V. System and method for administering light therapy
US20120209355A1 (en) * 2008-12-30 2012-08-16 Koninklijke Philips Electronics N.V. System and method for administering light therapy
US8517017B2 (en) 2009-01-08 2013-08-27 Hancock Medical, Inc. Self-contained, intermittent positive airway pressure systems and methods for treating sleep apnea, snoring, and other respiratory disorders
US20100170513A1 (en) * 2009-01-08 2010-07-08 Bowditch Nathaniel L Self-contained, intermittent positive airway pressure systems and methods for treating sleep apnea, snoring, and other respiratory disorders
US8424521B2 (en) 2009-02-27 2013-04-23 Covidien Lp Leak-compensated respiratory mechanics estimation in medical ventilators
US20100240982A1 (en) * 2009-03-17 2010-09-23 Advanced Brain Monitoring, Inc. System for the Assessment of Sleep Quality in Adults and Children
US8639313B2 (en) * 2009-03-17 2014-01-28 Advanced Brain Monitoring, Inc. System for the assessment of sleep quality in adults and children
US20130131464A1 (en) * 2009-03-17 2013-05-23 Advanced Brain Monitoring, Inc. System for the assessment of sleep quality in adults and children
US8355769B2 (en) * 2009-03-17 2013-01-15 Advanced Brain Monitoring, Inc. System for the assessment of sleep quality in adults and children
US9041925B2 (en) 2009-03-18 2015-05-26 Mannkind Corporation Laser diffraction with inhaler enclosed in positive pressure chamber
US8267085B2 (en) 2009-03-20 2012-09-18 Nellcor Puritan Bennett Llc Leak-compensated proportional assist ventilation
US8418691B2 (en) 2009-03-20 2013-04-16 Covidien Lp Leak-compensated pressure regulated volume control ventilation
US8978650B2 (en) 2009-03-20 2015-03-17 Covidien Lp Leak-compensated proportional assist ventilation
US8973577B2 (en) 2009-03-20 2015-03-10 Covidien Lp Leak-compensated pressure regulated volume control ventilation
US8448641B2 (en) 2009-03-20 2013-05-28 Covidien Lp Leak-compensated proportional assist ventilation
US8515515B2 (en) 2009-03-25 2013-08-20 Covidien Lp Medical sensor with compressible light barrier and technique for using the same
US8781548B2 (en) 2009-03-31 2014-07-15 Covidien Lp Medical sensor with flexible components and technique for using the same
US9630930B2 (en) 2009-06-12 2017-04-25 Mannkind Corporation Diketopiperazine microparticles with defined specific surface areas
WO2011051837A1 (en) 2009-10-28 2011-05-05 Koninklijke Philips Electronics N.V. Pressure support system with inductive tubing
US9278184B2 (en) 2009-10-28 2016-03-08 Koninklijke Philips N.V. Pressure support system with inductive tubing
US9016147B2 (en) 2009-11-03 2015-04-28 Mannkind Corporation Apparatus and method for simulating inhalation efforts
US9706944B2 (en) 2009-11-03 2017-07-18 Mannkind Corporation Apparatus and method for simulating inhalation efforts
US20110112382A1 (en) * 2009-11-12 2011-05-12 Nellcor Puritan Bennett Llc Systems and methods for combined physiological sensors
US20120240933A1 (en) * 2009-12-19 2012-09-27 Koninklijke Philips Electronics N.V. Pressure support system with mask fit feedback display
US9687624B2 (en) * 2009-12-19 2017-06-27 Koninklijke Philips N.V. Pressure support system with mask fit feedback display
US20110196251A1 (en) * 2010-02-10 2011-08-11 Nellcor Puritan Bennett Llc Leak determination in a breathing assistance system
US9254369B2 (en) 2010-02-10 2016-02-09 Covidien Lp Leak determination in a breathing assistance system
US8707952B2 (en) 2010-02-10 2014-04-29 Covidien Lp Leak determination in a breathing assistance system
US8939150B2 (en) 2010-02-10 2015-01-27 Covidien Lp Leak determination in a breathing assistance system
US8573199B2 (en) * 2010-04-30 2013-11-05 Centers For Disease Control And Prevention Ultrasonic in situ respiratory mask testing process and mask
US20110270085A1 (en) * 2010-04-30 2011-11-03 Centers For Disease Control And Prevention Ultrasonic in situ respiratory mask testing process and mask
US9724546B2 (en) * 2010-09-03 2017-08-08 Qinetiq Limited Respiratory protection equipment
US20130180523A1 (en) * 2010-09-03 2013-07-18 Qinetiq Limited Respiratory protection equipment
US9888858B2 (en) * 2010-11-23 2018-02-13 Resmed Limited Method and apparatus for detecting cardiac signals
US20130237793A1 (en) * 2010-11-23 2013-09-12 Resmed Limited Method and apparatus for detecting cardiac signals
US8803682B2 (en) 2010-12-07 2014-08-12 J.T. Labs Limited Sleep-posture sensing and monitoring system
US8919344B2 (en) 2011-02-08 2014-12-30 Hancock Medical, Inc. Positive airway pressure system with head position control
US9180267B2 (en) 2011-02-08 2015-11-10 Hancock Medical, Inc. Positive airway pressure system with head position control
US8336546B2 (en) 2011-02-08 2012-12-25 Hancock Medical, Inc. Positive airway pressure system with head control
US8327846B2 (en) 2011-02-08 2012-12-11 Hancock Medical, Inc. Positive airway pressure system with head position control
US8925546B2 (en) 2011-02-08 2015-01-06 Hancock Medical, Inc. Positive airway pressure system with head position control
WO2012106775A1 (en) * 2011-02-11 2012-08-16 Resmed Limited Method and apparatus for treatment of sleep disorders
US9597479B2 (en) 2011-02-11 2017-03-21 Redmed Limited Method and apparatus for treatment of sleep disorders
US9364436B2 (en) 2011-06-17 2016-06-14 Mannkind Corporation High capacity diketopiperazine microparticles and methods
US20140202455A1 (en) * 2011-08-25 2014-07-24 Koninklijke Philips N.V. Method and apparatus for controlling a ventilation therapy device
US9610351B2 (en) 2011-10-24 2017-04-04 Mannkind Corporation Methods and compositions for treating pain
US9233159B2 (en) 2011-10-24 2016-01-12 Mannkind Corporation Methods and compositions for treating pain
US9498589B2 (en) 2011-12-31 2016-11-22 Covidien Lp Methods and systems for adaptive base flow and leak compensation
CN104394919A (en) * 2012-06-08 2015-03-04 皇家飞利浦有限公司 Patient interface with cushion for red mark prevention
WO2013183018A1 (en) * 2012-06-08 2013-12-12 Koninklijke Philips N.V. Patient interface with cushion for red mark prevention
RU2639034C2 (en) * 2012-06-08 2017-12-19 Конинклейке Филипс Н.В. Patient interface with gasket for red traces prevention
US9814426B2 (en) 2012-06-14 2017-11-14 Medibotics Llc Mobile wearable electromagnetic brain activity monitor
US20140005497A1 (en) * 2012-07-02 2014-01-02 Honeywell International Inc. Mask having integrated physiological condition sensors
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
US20150224275A1 (en) * 2012-08-09 2015-08-13 Sander Theodoor Pastoor Customisation or adjustment of patient interfaces
CN102974020A (en) * 2012-12-25 2013-03-20 苏州凯迪泰医学科技有限公司 Forehead cushion provided with blood oxygen detection device and breathing mask
US20160045161A1 (en) * 2013-01-14 2016-02-18 University Health Network Mask and method for breathing disorder identification, characterization and/or diagnosis
WO2014117179A1 (en) * 2013-01-28 2014-07-31 Hancock Medical, Inc. Position control devices and methods for use with positive airway pressure systems
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
US20150027442A1 (en) * 2013-07-23 2015-01-29 Lockheed Martin Corporation Respiratory Gas Monitoring
US9913997B2 (en) * 2013-07-23 2018-03-13 Lockheed Martin Corporation Respiratory gas monitoring
WO2015021064A1 (en) * 2013-08-05 2015-02-12 Mannkind Corporation Insufflation apparatus and methods
CN105517607A (en) * 2013-08-05 2016-04-20 曼金德公司 Insufflation apparatus and methods
US9675771B2 (en) 2013-10-18 2017-06-13 Covidien Lp Methods and systems for leak estimation
WO2015128173A1 (en) * 2014-02-26 2015-09-03 Koninklijke Philips N.V. Patient interface with automatic position adjustment
US9925347B2 (en) * 2014-10-02 2018-03-27 Koninklijke Philips N.V. Cushion element for a patient interface
US20170203069A1 (en) * 2014-10-02 2017-07-20 Koninklijke Philips N.V. Cushion element for a patient interface
USD757244S1 (en) * 2015-02-27 2016-05-24 Sls Medical Technology Corp. Ltd. Sensor for respirator mask
USD776802S1 (en) 2015-03-06 2017-01-17 Hancock Medical, Inc. Positive airway pressure system console
WO2016154067A1 (en) * 2015-03-20 2016-09-29 Bohnas LLC Breathing detection apparatus
US9808182B2 (en) 2015-03-20 2017-11-07 Bohnas LLC Breathing detection apparatus
US20170188856A1 (en) * 2016-01-05 2017-07-06 Tosense, Inc. Floormat physiological sensor

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