US20040133157A1 - Balloon occlusion diameter and pressure measuring devices and methods of use - Google Patents
Balloon occlusion diameter and pressure measuring devices and methods of use Download PDFInfo
- Publication number
- US20040133157A1 US20040133157A1 US10/701,786 US70178603A US2004133157A1 US 20040133157 A1 US20040133157 A1 US 20040133157A1 US 70178603 A US70178603 A US 70178603A US 2004133157 A1 US2004133157 A1 US 2004133157A1
- Authority
- US
- United States
- Prior art keywords
- balloon
- pressure
- inflation
- vessel
- balloons
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1018—Balloon inflating or inflation-control devices
- A61M25/10181—Means for forcing inflation fluid into the balloon
- A61M25/10182—Injector syringes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1018—Balloon inflating or inflation-control devices
- A61M25/10184—Means for controlling or monitoring inflation or deflation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1018—Balloon inflating or inflation-control devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1018—Balloon inflating or inflation-control devices
- A61M25/10184—Means for controlling or monitoring inflation or deflation
- A61M25/10187—Indicators for the level of inflation or deflation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M2025/0001—Catheters; Hollow probes for pressure measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1059—Balloon catheters with special features or adapted for special applications having different inflatable sections mainly depending on the response to the inflation pressure, e.g. due to different material properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1068—Balloon catheters with special features or adapted for special applications having means for varying the length or diameter of the deployed balloon, this variations could be caused by excess pressure
Abstract
The invention provides a device having first and second balloons. Each of the first and second balloons communicates with an inflation lumen. A differential pressure gauge communicates with both inflation lumens. Each of the inflation lumens also communicates independently with a pump for inflating the balloon. The pressure gauge may include a shut-off valve for terminating inflation in the second balloon when the pressure within the first balloon exceeds the pressure in the second balloon. The pressure gauge may also include a pressure limiter. Methods of using the devices for measuring diameter and pressure of a balloon occluder deployed in a vessel or body cavity are disclosed.
Description
- This is a continuation of U.S. application Ser. No. 09/687,922, filed Oct. 13, 2000, which is a continuation of U.S. application Ser. No. 09/307,092, filed May 7, 1999, now U.S. Pat. No. 6,146,357, all of which are incorporated herein by reference in its entirety.
- The present invention relates generally to medical devices useful for measuring the diameter and pressure of a balloon occluder deployed within a vessel. More particularly, the devices provide information on when the balloon occluder engages the vessel wall, diameter of the vessel wall, and force exerted on the vessel wall.
- Balloon occlusion devices are commonly deployed within a vessel during various cardiovascular surgeries to provide isolation of blood flow. During conventional or minimally invasive surgeries, including coronary artery bypass grafting, heart valve repair or replacement, septal defect repair, pulmonary thrombectomy, atherectomy, aneurysm repair, aortic dissection repair and correction of congenital defects, for example, circulatory isolation of the coronary blood flow from the peripheral vascular system is often required to establish cardiopulmonary bypass. Instead of using the traditional methods of aortic clamping, a balloon occluder is sometimes used to isolate blood flow in the aorta. Presently, balloon occluders are built to expand to the approximate lumenal diameter of the vessel, i.e., a balloon occluder with a smaller diameter would be used for the carotid artery while larger balloons are used in the aorta. Balloon occlusion devices are also used in other nonvascular procedures, such as dilation of an esophageal stricture in patients with achalasia, or dilation of an intra and/or extrahepatic bile duct in patients with biliary stenosis.
- There are several disadvantages associated with the current methods of inflating a balloon occluder in a vessel or body cavity. First, the optimal size of the balloon occluder for occluding the lumen of the vessel or the body cavity is unknown and is usually estimated according to the average lumenal diameter. The vessel may be affected by atherosclerosis, and the actual lumenal diameter may be reduced. Second, as the balloon is inflated to occlude the lumen of the vessel or body cavity, the point of contact of the perimeter of the balloon with the wall of the vessel or body cavity is uncertain. The operator can only estimate an acceptable level of wall distention. Third, the pressure generated by the expanded balloon on the wall of the vessel or body cavity is unknown. Complications due to over-inflation of the balloon may occur, including (1) atherosclerotic plaque rupture leading to distal embolization, (2) dissection of the vessel wall, (3) pseudoaneurysm formation due to subintimal hemorrhage, (4) aneurysm formation due to hyperextension and weakening of the vessel wall, (5) diverticulum formation due to weakening of the body tissue, and (6) vessel wall rupture or organ perforation.
- New devices and methods are thus needed for balloon occlusion of a vessel or body cavity, in order to provide information on the effective diameter of the vessel or body cavity and allow an operator to optimally control the inflation of the balloon without damage to the vessel wall or body tissue.
- The invention provides devices and methods for controlling the inflation of balloon occlusion devices. One embodiment of the devices includes first and second balloons. The first balloon is adapted for insertion into a patient's vessel or body cavity. The balloons may be elastomeric or non-elastomeric balloons. Each of the two balloons communicates with an inflation lumen. Each inflation lumen communicates independently with a pump for inflating the balloon. Both lumens communicate with a differential pressure gauge, which measures the pressure inside each balloon, compares both pressures, and displays the information.
- In another embodiment, the pumps are syringes, which are adapted for infusion of air or fluid into the balloon. The syringes may operate in tandem for inflating the balloons simultaneously. In still another embodiment, the pressure gauge includes a shut-off valve, operably associated with the second inflation lumen. The valve enables the pressure gauge to terminate inflation into the second lumen and balloon after the pressure in the first balloon exceeds a certain threshold. In certain embodiments, the gauge may include a pressure limiter which limits the pressure in the first balloon from exceeding a set threshold, thereby avoiding over-inflation of the first balloon inside the vessel or body cavity.
- The invention provides methods for measuring the pressure of a balloon occluder deployed in a patient's vessel or body cavity, e.g., bile duct. In a first method, using the devices described above, the first balloon is inserted through an incision into the lumen of a patient's vessel, e.g., aorta, or body cavity while maintaining the second balloon outside the patient's body. The first and second balloons are inflated simultaneously at the same rate of inflation by operating the pumps, which infuse air or fluid into the inflation lumens. The pressure within the first and second balloons are measured and compared by the differential pressure gauge, which comparison indicates when the first balloon engages the lumenal wall of the vessel or body cavity. As the first balloon contacts the vessel wall, the pressure in the first balloon rises disproportionately compared to the second balloon. The operator may then terminate inflation in the first balloon to avoid over-inflation.
- In another method, when the pressure in the first balloon exceeds the pressure in the second balloon, the pressure gauge may activate the shut-off valve, thereby terminating the inflation of the second balloon. The gauge may be reset to measure the pressure within the first balloon and the atmosphere. In this way, any increase in the pressure in the first balloon is caused by the resistance of the vessel wall against the expanding balloon. The less compliant the vessel, e.g., artery with atherosclerotic plaque, the higher the resistance of the vessel wall and the higher the pressure registered in the pressure gauge. In the embodiment where the pressure gauge includes a pressure limiter, the limiter may sound an alarm when the pressure in the first balloon exceeds a set threshold, thereby avoiding complications associated with over-inflation of the balloon occluder.
- It will be understood that there are several advantages to using the balloon occlusion measuring devices and methods disclosed herein. For example, the devices (1) notify the physician when the balloon contacts a vessel wall, (2) provide information on the diameter of the vessel wall, (3) provide information on pressure exerted on the vessel wall, (4) can be employed in any vessel with or without stenosis, (5) can be employed to occlude or dilate a body cavity, and (6) minimize complications associated with over-inflation of the balloon occluder, i.e., wall rupture, dissection, pseudoaneurysm, and/or embolization.
- FIG. 1 depicts an embodiment of the balloon occluder pressure measuring device according to the present invention.
- FIG. 2A depicts a first balloon deployed in the aorta and a second balloon outside the aorta.
- FIG. 2B depicts the first balloon of FIG. 2A engaging the aortic wall.
- FIG. 2C depicts a graph of the pressure differential between the first and second balloons versus time.
- The balloon occluder pressure measuring devices and methods are most useful in providing optimal inflation of a balloon occluder deployed in a patient's vessel, e.g., aortic occlusion for cardiopulmonary bypass, and in preventing complications associated with balloon over-inflation. It will be understood that the devices and methods may also be used to provide optimal balloon inflation in occluding or dilating a patient's body cavity, e.g., the esophagus in patients with achalasia or the bile duct in biliary stenosis.
- In FIG. 1,
first balloon 10, which is inserted in the lumen ofvessel 100, communicates withinflation lumen 12.Second balloon 20, which is outside the vessel, communicates withinflation lumen 22. Bothlumens differential pressure gauge 50.Inflation lumens pumps lumen 14 of the syringe. Syringe 26 has plunger 25 disposed withinlumen 24 of the syringe. The syringes deliver air or fluid to the balloons through their respective inflation lumens. Proximal ends ofplungers balloons balloon occluder 10 is deployed invessel 100, balloons 10 and 20 are inflated simultaneously, and at the same rate by advancingplungers lumens balloons balloons pressure gauge 50. - In FIG. 2A,
balloon 10, having pressure P1 inside the balloon, is deployed withinvessel 100, andballoon 20, having pressure P2 inside the balloon, is outside the vessel. As both balloons are inflated,balloon 10 engages the wall ofvessel 100 as shown in FIG. 2B. Once contact is achieved with the vessel wall, the pressure withinballoon 10 rises disproportionately to that ofballoon 20, i.e., P1>>P2. The relationship between the pressure differential forballoons 10 and 20 (P1/P2) with inflation time (t) is illustrated in FIG. 2C. Time t1 indicates whenballoon 10 engages the vessel wall as depicted in FIG. 2B. Before t1, the pressure differential betweenballoons - In the embodiments where the pressure gauge includes a shut-off valve operably associated with the second inflation lumen, inflation of
balloon 20 may be terminated when the first balloon makes contact with the vessel wall. The gauge may be reset to measure the pressure withinballoon 10 and the atmosphere, so that P1/P2 reflects the resistance generated by the vessel wall. The less compliant the vessel, e.g., artery with atherosclerosis plaque, the higher the resistance of the vessel wall. In this way, the devices provide the physician information on (1) when the balloon occluder device contacts the vessel wall, (2) the effective lumenal diameter of the vessel, and (3) force exerted on the vessel wall. - In still another embodiment, the pressure measuring device need not include a second balloon for pressure monitoring outside the body. In this embodiment, the physician carefully monitors the pressure gauge, noting when a significant pressure increase occurs (t=t1, when the balloon engages the vessel wall). Balloon inflation is then terminated to avoid vessel hyperextension.
- The length of the inflation lumen will generally be between 10 and 200 centimeters, preferably approximately between 30 and 150 centimeters. The inner diameter of the inflation lumen will generally be between 0.05 and 0.5 centimeters, preferably approximately between 0.1 and 0.3 centimeters. The diameter of the expanded occluder will generally be between 0.3 and 2 centimeters, preferably approximately 0.5 and 1.0 centimeters. The foregoing ranges are set forth solely for the purpose of illustrating typical device dimensions. The actual dimensions of a device constructed according to the principles of the present invention may obviously vary outside of the listed ranges without departing from those basic principles.
- Although the foregoing invention has, for the purposes of clarity and understanding, been described in some detail by way of illustration and example, it will be obvious that certain changes and modifications may be practiced which will still fall within the scope of the appended claims.
Claims (9)
1. A balloon occlusion inflation apparatus, comprising:
a first balloon which communicates with a first inflation lumen;
a second balloon which communicates with a second inflation lumen; and
a pressure gauge communicating with the first inflation lumen and independently and simultaneously communicating with the second inflation lumen to permit a comparison of a detected pressure of the first balloon with a detected pressure of the second balloon.
2. The apparatus of claim 1 , wherein the first and second balloons are elastomeric.
3. The apparatus of claim 1 , wherein the first and second balloons are non-elastomeric.
4. The apparatus of claim 1 , further comprising a first pump that communicates with the first inflation lumen and a second pump that communicates with the second inflation lumen, wherein the first and second pumps are syringes.
5. The apparatus of claim 4 , wherein the syringes are tandem acting syringes.
6. The apparatus of claim 1 , wherein the pressure gauge includes a shut-off valve, operably associated with the second inflation lumen.
7. The apparatus of claim 1 , wherein the pressure gauge includes a pressure limiter.
8. The apparatus of claim 1 , wherein the pressure gauge is a differential pressure gauge.
9. The apparatus of claim 1 , further comprising a first pump communicating with the first inflation lumen and a second pump communicating with the second inflation lumen.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/701,786 US20040133157A1 (en) | 1999-05-07 | 2003-11-04 | Balloon occlusion diameter and pressure measuring devices and methods of use |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/307,092 US6146357A (en) | 1999-05-07 | 1999-05-07 | Balloon occlusion diameter and pressure measuring devices and methods of use |
US09/687,922 US6656154B1 (en) | 1999-05-07 | 2000-10-13 | Balloon occlusion diameter and pressure measuring devices and methods of use |
US10/701,786 US20040133157A1 (en) | 1999-05-07 | 2003-11-04 | Balloon occlusion diameter and pressure measuring devices and methods of use |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/687,922 Continuation US6656154B1 (en) | 1999-05-07 | 2000-10-13 | Balloon occlusion diameter and pressure measuring devices and methods of use |
Publications (1)
Publication Number | Publication Date |
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US20040133157A1 true US20040133157A1 (en) | 2004-07-08 |
Family
ID=23188206
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/307,092 Expired - Lifetime US6146357A (en) | 1999-05-07 | 1999-05-07 | Balloon occlusion diameter and pressure measuring devices and methods of use |
US09/687,922 Expired - Lifetime US6656154B1 (en) | 1999-05-07 | 2000-10-13 | Balloon occlusion diameter and pressure measuring devices and methods of use |
US10/701,786 Abandoned US20040133157A1 (en) | 1999-05-07 | 2003-11-04 | Balloon occlusion diameter and pressure measuring devices and methods of use |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/307,092 Expired - Lifetime US6146357A (en) | 1999-05-07 | 1999-05-07 | Balloon occlusion diameter and pressure measuring devices and methods of use |
US09/687,922 Expired - Lifetime US6656154B1 (en) | 1999-05-07 | 2000-10-13 | Balloon occlusion diameter and pressure measuring devices and methods of use |
Country Status (1)
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US (3) | US6146357A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060116586A1 (en) * | 2004-11-05 | 2006-06-01 | Fujinon Corporation | Balloon controller for endoscopic apparatus |
US20090076439A1 (en) * | 2007-09-14 | 2009-03-19 | Dollar Michael L | Inflation System for Balloon Catheter |
USRE49218E1 (en) * | 2010-11-08 | 2022-09-27 | Conavi Medical Inc. | Systems and methods for improved visualization during minimally invasive procedures |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6146357A (en) * | 1999-05-07 | 2000-11-14 | Embol-X, Inc. | Balloon occlusion diameter and pressure measuring devices and methods of use |
US20030050648A1 (en) | 2001-09-11 | 2003-03-13 | Spiration, Inc. | Removable lung reduction devices, systems, and methods |
US6592594B2 (en) | 2001-10-25 | 2003-07-15 | Spiration, Inc. | Bronchial obstruction device deployment system and method |
US6929637B2 (en) | 2002-02-21 | 2005-08-16 | Spiration, Inc. | Device and method for intra-bronchial provision of a therapeutic agent |
US20030181922A1 (en) | 2002-03-20 | 2003-09-25 | Spiration, Inc. | Removable anchored lung volume reduction devices and methods |
US20040059263A1 (en) * | 2002-09-24 | 2004-03-25 | Spiration, Inc. | Device and method for measuring the diameter of an air passageway |
US20040010209A1 (en) * | 2002-07-15 | 2004-01-15 | Spiration, Inc. | Device and method for measuring the diameter of an air passageway |
US7100616B2 (en) | 2003-04-08 | 2006-09-05 | Spiration, Inc. | Bronchoscopic lung volume reduction method |
GB0314863D0 (en) * | 2003-06-26 | 2003-07-30 | Univ Dundee | Medical apparatus and method |
US7533671B2 (en) | 2003-08-08 | 2009-05-19 | Spiration, Inc. | Bronchoscopic repair of air leaks in a lung |
US7468051B2 (en) | 2004-03-02 | 2008-12-23 | Boston Scientific Scimed, Inc. | Occlusion balloon catheter with external inflation lumen |
US7198632B2 (en) * | 2004-03-02 | 2007-04-03 | Boston Scientific Scimed, Inc. | Occlusion balloon catheter with longitudinally expandable balloon |
US7256702B2 (en) * | 2004-08-18 | 2007-08-14 | Michael S. Isaacs | Gas supply pressure alarm device |
US7691151B2 (en) | 2006-03-31 | 2010-04-06 | Spiration, Inc. | Articulable Anchor |
US8043301B2 (en) | 2007-10-12 | 2011-10-25 | Spiration, Inc. | Valve loader method, system, and apparatus |
CN101868199B (en) | 2007-10-12 | 2016-04-06 | 斯波瑞申有限公司 | valve loader method, system and equipment |
JP5107065B2 (en) * | 2008-01-15 | 2012-12-26 | オリンパスメディカルシステムズ株式会社 | Inner diameter measuring tool |
US8795241B2 (en) | 2011-05-13 | 2014-08-05 | Spiration, Inc. | Deployment catheter |
ES2820308T3 (en) | 2015-06-30 | 2021-04-20 | Cosette Lee & Harrison Llc | Endovascular catheter with multiple capacities |
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US4177801A (en) * | 1976-07-30 | 1979-12-11 | Dubernard Hospital, S.A. | Process and apparatus for the non-intrusive measurement of circulatory parameters |
US5181517A (en) * | 1989-09-18 | 1993-01-26 | The State University Of New York | Method and apparatus for the measurement of atrial pressure |
US6146357A (en) * | 1999-05-07 | 2000-11-14 | Embol-X, Inc. | Balloon occlusion diameter and pressure measuring devices and methods of use |
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US4439185A (en) * | 1981-10-21 | 1984-03-27 | Advanced Cardiovascular Systems, Inc. | Inflating and deflating device for vascular dilating catheter assembly |
US4753238A (en) * | 1987-01-06 | 1988-06-28 | Advanced Cardiovascular Systems, Inc. | Proximal manifold and adapter |
US5795325A (en) | 1991-07-16 | 1998-08-18 | Heartport, Inc. | Methods and apparatus for anchoring an occluding member |
US5591195A (en) * | 1995-10-30 | 1997-01-07 | Taheri; Syde | Apparatus and method for engrafting a blood vessel |
EP0873145A2 (en) * | 1996-11-15 | 1998-10-28 | Advanced Bio Surfaces, Inc. | Biomaterial system for in situ tissue repair |
-
1999
- 1999-05-07 US US09/307,092 patent/US6146357A/en not_active Expired - Lifetime
-
2000
- 2000-10-13 US US09/687,922 patent/US6656154B1/en not_active Expired - Lifetime
-
2003
- 2003-11-04 US US10/701,786 patent/US20040133157A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4177801A (en) * | 1976-07-30 | 1979-12-11 | Dubernard Hospital, S.A. | Process and apparatus for the non-intrusive measurement of circulatory parameters |
US5181517A (en) * | 1989-09-18 | 1993-01-26 | The State University Of New York | Method and apparatus for the measurement of atrial pressure |
US6146357A (en) * | 1999-05-07 | 2000-11-14 | Embol-X, Inc. | Balloon occlusion diameter and pressure measuring devices and methods of use |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060116586A1 (en) * | 2004-11-05 | 2006-06-01 | Fujinon Corporation | Balloon controller for endoscopic apparatus |
US7901347B2 (en) * | 2004-11-05 | 2011-03-08 | Fujinon Corporation | Balloon controller for endoscopic apparatus |
US20090076439A1 (en) * | 2007-09-14 | 2009-03-19 | Dollar Michael L | Inflation System for Balloon Catheter |
USRE49218E1 (en) * | 2010-11-08 | 2022-09-27 | Conavi Medical Inc. | Systems and methods for improved visualization during minimally invasive procedures |
Also Published As
Publication number | Publication date |
---|---|
US6656154B1 (en) | 2003-12-02 |
US6146357A (en) | 2000-11-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |