US20020107437A1 - Subcutaneous cavity marking device and method - Google Patents

Subcutaneous cavity marking device and method Download PDF

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Publication number
US20020107437A1
US20020107437A1 US10114712 US11471202A US2002107437A1 US 20020107437 A1 US20020107437 A1 US 20020107437A1 US 10114712 US10114712 US 10114712 US 11471202 A US11471202 A US 11471202A US 2002107437 A1 US2002107437 A1 US 2002107437A1
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Prior art keywords
cavity
device
marker
body
marking
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Abandoned
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US10114712
Inventor
D. Sirimanne
Douglas Sutton
Natalie Fawzi
Gail Lebovic
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Devicor Medical Products Inc
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Sirimanne D. Laksen
Sutton Douglas S.
Fawzi Natalie V.
Gail Lebovic
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48Diagnostic techniques
    • A61B8/481Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39Markers, e.g. radio-opaque or breast lesions markers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/006Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/22Echographic preparations; Ultrasound imaging preparation Optoacoustic imaging preparations
    • A61K49/222Echographic preparations; Ultrasound imaging preparation Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3904Markers, e.g. radio-opaque or breast lesions markers specially adapted for marking specified tissue
    • A61B2090/3908Soft tissue, e.g. breast tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3987Applicators for implanting markers

Abstract

These are subcutaneous cavity marking devices and methods. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammographic, echogenic, or other non-invasive imaging techniques. Also, the device contains a bioabsorbable or non-bioabsorbable marker. The device may be combined with various substances enhancing the radiopaque, mammographic, or echogenic characteristics of the marker or the body allowing it to be observed by any non-invasive imaging techniques. This is further a method of marking a subcutaneous cavity using a bioabsorbable material and a bioabsorbable or non-bioabsorbable marker in conjunction with the material. The method also may combine any of the features as described with the device.

Description

    RELATED APPLICATIONS
  • [0001]
    This application is a continuation of U.S. Ser. No. 09/285,329 filed Apr. 2, 1999, which is a continuation-in-part of U.S. Ser. No. 09/220,618, filed Dec. 24, 1998.
  • FIELD OF THE INVENTION
  • [0002]
    This invention is directed to subcutaneous cavity marking devices and methods. More particularly, a cavity marking device and method is disclosed that enable one to determine the location, orientation, and periphery of the cavity by radiographic, mammographic, echographic, or other non-invasive techniques. The invention typically is made up of one or more resilient bodies and a radiopaque or echogenic marker.
  • BACKGROUND OF THE INVENTION
  • [0003]
    Over 1.1 million breast biopsies are performed each year in the United States alone. Of these, about 80% of the lesions excised during biopsy are found to be benign while about 20% of these lesions are malignant.
  • [0004]
    In the field of breast cancer, stereotactically guided and percutaneous biopsy procedures have increased in frequency as well as in accuracy as modem imaging techniques allow the physician to locate lesions with ever-increasing precision. However, for any given biopsy procedure, a subsequent examination of the biopsy site is very often desirable. There is an important need to determine the location, most notably the center, as well as the orientation and periphery (margins) of the subcutaneous cavity from which the lesion is removed.
  • [0005]
    In those cases where the lesion is found to be benign, for example, a follow-up examination of the biopsy site is often performed to ensure the absence of any suspect tissue and the proper healing of the cavity from which the tissue was removed. This is also the case where the lesion is found to be malignant and the physician is confident that all suspect tissue was removed and the tissue in the region of the perimeter or margins of the cavity is “clean”.
  • [0006]
    In some cases, however, the physician may be concerned that the initial biopsy failed to remove a sufficient amount of the lesion. Such a lesion is colloquially referred to as a “dirty lesion” or “dirty margin” and requires follow-up observation of any suspect tissue growth in the surrounding marginal area of the initial biopsy site. Thus, a re-excision of the original biopsy site must often be performed. In such a case, the perimeter of the cavity must be identified since the cavity may contain cancerous cells. Identification of the cavity perimeter is necessary to avoid the risk of opening the cavity, which could release and spread cancerous cells. Moreover, the site of the re-excised procedure itself requires follow-up examination, providing further impetus for accurate identification of the location of the re-excised site. Therefore, a new marker will be placed after re-excision.
  • [0007]
    Prior methods of marking biopsy cavities utilize one or more tissue marking clips as the biopsy site marking device. Most commonly, these marker clips have a “horseshoe” configuration. The marker clips attach to the walls of the cavity when the free ends or limbs of the “horseshoe” are pinched together, trapping the tissue. This device has significant drawbacks.
  • [0008]
    For instance, prior to placing the marker clip at the cavity site, the site must be thoroughly cleaned, typically by vacuum, to remove any residual tissue debris. This minimizes the possibility that the marker clip attaches to any loose tissue as opposed to the cavity wall. Once the cavity is prepared, the clip must be examined to ensure that the limbs of the clip are substantially straight. If the limbs have been prematurely bent together, the clip will be discarded since it will most likely not attach properly to the cavity wall. Actual placement of the clip often requires additional vacuum of the cavity wall to draw the wall into the aperture between the limbs of the marking clip so that a better grip is obtained between the limbs of the clip. Additionally, there is always the possibility that the clip may detach from the cavity wall during or after withdrawal of the tools used to place the clip into the cavity.
  • [0009]
    Aside from the problems inherent in the placement of the marking clip, there are also limitations associated with how well the marking clip can identify a biopsy cavity. As the marking clip must trap tissue for proper attachment, in cases of endoscopic placement, the clip can only be placed on a wall of the cavity substantially opposite to the opening of the cavity.
  • [0010]
    Moreover, patient concern limits the number of clips that may be placed in a cavity. As a result, the medical practitioner is forced to identify the outline of a three dimensional cavity by a single point as defined by the marking clip. Obviously, determination of the periphery of a biopsy cavity from one point of the periphery is not possible.
  • [0011]
    These limitations are compounded as the biopsy cavity fills within a few hours with bodily fluids, which eventually renders the cavity invisible to non-invasive techniques. Another difficulty in viewing the clip stems from the fact that the clip is attached to the side, not the center, of the cavity. This makes determining the spatial orientation and position of the cavity difficult if not impossible during follow-up examination. Additionally, during a stereotactic breast biopsy procedure, the breast is under compression when the marking clip is placed. Upon release of the compressive force, determining the location of the clip can be unpredictable, and the orientation as well as the location of the periphery of the cavity are lost.
  • [0012]
    The marker clip does not aid in the healing process of the biopsy wound. Complications may arise if the marker strays from its original placement site. As described above, if a re-excision of the site is required, the marker clip may also interfere when excision of a target lesion is sought.
  • [0013]
    Other devices pertaining to biopsy aids are directed to assisting in the healing and closure of the biopsy wound; thus they do not aid the clinical need or desirability of accurately preserving the location and orientation of the biopsy cavity. See, e.g., U.S. Pat. Nos. 4,347,234, 5,388,588, 5,326,350, 5,394,886, 5,467,780, 5,571,181, and 5,676,146.
  • SUMMARY OF THE INVENTION
  • [0014]
    This invention relates to devices and procedures for percutaneously marking a biopsy cavity. In particular, the inventive device is a biopsy cavity-marking body made of a resilient, preferably bioabsorbable material having at least one preferably radiopaque or echogenic marker. The device may take on a variety of shapes and sizes tailored for the specific biopsy cavity to be filled. For example, the device in its simplest form is a spherical or cylindrical collagen sponge having a single radiopaque or echogenic marker located in its geometric center. Alternatively, the body may have multiple components linked together with multiple radiopaque or echogenic markers.
  • [0015]
    A further aspect of the invention allows the marker or the body, singly or in combination, to be constructed to have a varying rate of degradation or bioabsorption. For instance, the body may be constructed to have a layer of bioabsorbable material as an outer “shell.” Accordingly, prior to degradation of the shell, the body is palpable. Upon degradation of the shell, the remainder of the body would degrade at an accelerated rate in comparison to the outer shell.
  • [0016]
    The device may additionally contain a variety of drugs, such as hemostatic agents, pain-killing substances, or even healing or therapeutic agents that may be delivered directly to the biopsy cavity. Importantly, the device is capable of accurately marking a specific location, such as the center, of the biopsy cavity, and providing other information about the patient or the particular biopsy or device deployed.
  • [0017]
    The device is preferably, although not necessarily, delivered immediately after removal of the tissue specimen using the same device used to remove the tissue specimen itself. Such devices are described in pending U.S. patent application Ser. No. 09/145,487 (Attorney Docket No. 41269-20002.00), filed Sep. 1, 1998 and entitled “PERCUTANEOUS TISSUE REMOVAL DEVICE”, and pending U.S. patent application Ser. No. 09/184,766 (Attorney Docket No. 41269-20001.20), filed Nov. 2, 1998 and entitled “EXPANDABLE RING PERCUTANEOUS TISSUE REMOVAL DEVICE” the entirety of each are which hereby incorporated by reference. The device is compressed and loaded into the access device and percutaneously advanced to the biopsy site where, upon exiting from the access device, it expands to substantially fill the cavity of the biopsy. Follow-up noninvasive detection techniques, such as x-ray mammography or ultrasound may then be used by the physician to identify, locate, and monitor the biopsy cavity site over a preferred period of time.
  • [0018]
    The device is usually inserted into the body either surgically via an opening in the body cavity, or through a minimally invasive procedure using such devices as a catheter, introducer or similar type device. When inserted via the minimally invasive procedure, the resiliency of the body allows the device to be compressed upon placement in a delivery device. Upon insertion of the cavity marking device into the cavity, the resiliency of the body causes the cavity marking device to self-expand, substantially filling the cavity. The resiliency of the body can be further pre-determined so that the body is palpable, thus allowing tactile location by a surgeon in subsequent follow-up examinations. Typically, the filler body is required to be palpable for approximately 3 months. However, this period may be increased or decreased as needed.
  • [0019]
    The expansion of the resilient body can be aided by the addition of a bio-compatible fluid which is absorbed into the body. For instance, the fluid can be a saline solution, a painkilling substance, a healing agent, a therapeutic fluid, or any combination of such fluids. The fluid or combination of fluids may be added to and absorbed by the body of the device before or after deployment of the device into a cavity. For example, the body of the device may be pre-soaked with the fluid and then delivered into the cavity. In this instance, the fluid aids the expansion of the body of the device upon deployment. Another example is provided as the device is delivered into the cavity without being pre-soaked. In such a case, fluid is delivered into the cavity after the body of the device is deployed into the cavity. Upon delivery of the fluid, the body of the device soaks the fluid, thereby aiding the expansion of the cavity marking device as it expands to fit the cavity. The fluid may be, but is not limited to being, delivered by the access device.
  • [0020]
    By “bio-compatible fluid” what is meant is a liquid, solution, or suspension that may contain inorganic or organic material. For instance, the bio-compatible fluid is preferably saline solution, but may be water or contain adjuvants such as medications to prevent infection, reduce pain, or the like. Obviously, the liquid is intended to be a type that does no harm to the body.
  • [0021]
    After placement of the cavity marking device into the cavity, the bioabsorbable body degrades at a predetermined rate. As the body of the cavity marking device is absorbed, tissue is substituted for the bioabsorbable material. Moreover, while the body degrades, the marker, which is usually suspended substantially in the volumetric center of the body of the device, is left in the center of the cavity. Thus, during a subsequent examination, a medical practitioner having knowledge of the dimensions of the body of the cavity marking device can determine the location as well as the periphery of the biopsy cavity. The orientation of the cavity is self-evident as the marker is left in substantially the center of the cavity. For the case where multiple markers are used, the markers are usually placed in a manner showing directionality.
  • [0022]
    Both the body and the marker can be made, via radiopaque or echogenic coatings or in situ, to degrade and absorb into the patient's body over a predetermined period of time. It is generally preferred that if the marker's radiopacity or echogenicity is chosen to degrade over time, such degradation does not take place within at least one year after implantation of the inventive device. In this way, if a new lump or calcification (in the case of a breast biopsy) is discovered after the biopsy, such a marker will allow the physician to know the relation of such new growth in relation to the region of excised tissue. On the other hand, and as discussed below, a bioabsorption period of three months is preferred for any such coatings on the perimeter of the body itself
  • [0023]
    This invention further includes the act of filling the biopsy cavity with a bioabsorbable liquid, aerosol or gelatinous material, preferably gelatinous collagen, allowing the material to partially solidify or gel and then placing a marker, which may have a configuration as described above, into the center of the bioabsorbable material. The gel may also be made radiopaque or echogenic by the addition of radiopaque materials, such as barium- or bismuth-containing compounds and the like, as well as particulate radio-opaque fillers, e.g., powdered tantalum or tungsten, barium carbonate, bismuth oxide, barium sulfate, to the gel.
  • [0024]
    This method may be combined with any aspect of the previously described devices as needed. For instance, one could insert a hemostatic or pain-killing substance as described above into the biopsy cavity along with the bioabsorbable material. Alternatively, a bioabsorbable marker could be inserted into a predetermined location, such as the center, of the body of bioabsorbable material.
  • [0025]
    It is within the scope of this invention that either or both of the marker or markers and the bioabsorbable body may be radioactive, if a regimen of treatment using radioactivity is contemplated.
  • [0026]
    This procedure may be used in any internal, preferably soft, tissue, but is most useful in breast tissue, lung tissue, prostate tissue, lymph gland tissue, etc. Obviously, though, treatment and diagnosis of breast tissue problems forms the central theme of the invention.
  • [0027]
    In contrast to the marker clips as described above, the cavity marking device has the obvious advantage of marking the geometric center of a biopsy cavity. Also, unlike the marking clip which has the potential of attaching to loose tissue and moving after initial placement, the marking device self-expands upon insertion into the cavity, thus providing resistance against the walls of the cavity thereby anchoring itself within the cavity. The marking device may be configured to be substantially smaller, larger, or equal to the size of the cavity, however, in some cases the device will be configured to be larger than the cavity. This aspect of the biopsy marking device provides a cosmetic benefit to the patient, especially when the biopsy is taken from the breast. For example, the resistance provided by the cavity marking device against the walls of the cavity may minimize any “dimpling” effect observed in the skin when large pieces of tissue are removed, as, for example, during excisional biopsies.
  • [0028]
    Although the subcutaneous cavity marking device and method described above are suited for percutaneous placement of the marker within a biopsy cavity it is not intended that the invention is limited to such placement. The device and method are also appropriate for intra-operative or surgical placement of the marker within a biopsy cavity.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0029]
    [0029]FIG. 1A illustrates a tissue cavity marking device with a spherical body and a single centrally-located marker.
  • [0030]
    [0030]FIG. 1B shows a tissue cavity marking device with a cylindrical body and two ring-shaped markers aligned near the cylinder's longitudinal axis.
  • [0031]
    [0031]FIG. 1C shows another tissue cavity marking device with a multi-faced or irregular body and a single centrally-located marker.
  • [0032]
    [0032]FIG. 1D illustrates a tissue cavity marking device with a body having pores.
  • [0033]
    [0033]FIG. 1E is a partial cross-sectional view of FIG. 1D.
  • [0034]
    [0034]FIG. 1F illustrates a tissue cavity marking device with a body having an outer shell of a bioabsorbable material.
  • [0035]
    FIGS. 2A-2F illustrate various configurations of the marker.
  • [0036]
    [0036]FIG. 3A illustrates a cavity marking device having multiple body components traversed by a single wire or suture marker, or multiple wires or suture markers.
  • [0037]
    [0037]FIG. 3B illustrates a cavity marking device having a helically wound wire or suture marker.
  • [0038]
    [0038]FIG. 3C illustrates a cavity marking device having wire or suture markers on the perimeter of the body.
  • [0039]
    [0039]FIG. 3D illustrates a cavity marking device having wire or markers on the ends of the body.
  • [0040]
    FIGS. 4A-4C illustrate a method of marking a biopsy tissue cavity with the device of the present invention.
  • [0041]
    FIGS. 4D-4F illustrate a method of marking a biopsy tissue cavity with the device of the present invention wherein a bio-compatible fluid is delivered to the cavity marking device after placement.
  • [0042]
    FIGS. 4G-41 illustrate a method of marking a biopsy tissue cavity with the device of the present invention wherein a bio-compatible fluid is used to push the cavity marking device out of the access device and into the biopsy tissue cavity.
  • [0043]
    FIGS. 4J-4K illustrate a method of marking a biopsy tissue cavity with the device of the present invention wherein the body material of the marking device is deposited into the biopsy cavity prior to the placement of the marker within the biopsy device.
  • [0044]
    FIGS. 5A-B illustrate a spherical wire marking device for deployment without a filler body into a tissue cavity.
  • [0045]
    [0045]FIG. 5C illustrates a cylindrical wire marking device for deployment without a filler body into a tissue cavity.
  • [0046]
    FIGS. 5D-E illustrate a helical coil wire marking device for deployment without a filler body into a tissue cavity.
  • DETAILED DESCRIPTION OF THE INVENTION
  • [0047]
    FIGS. 1A-1C show various configurations of a preferred subcutaneous cavity marking device of the present invention. Here the marking device (100) is displayed as having either a generally spherical body (102) (FIG. 1A), a generally cylindrical body (104) (FIG. 1B), or a multi-faced or irregular body (106) (FIG. 1C). In general, it is within the scope of this invention for the body to assume a variety of shapes. For example, the body may be constructed to have substantially curved surfaces, such as the preferred spherical (102) and cylindrical (104) bodies of FIGS. 1A and 1B, respectively. The body may have conical or ellipsoidal, etc. shapes as well. It is further within the scope of this invention for the body to have substantially planar surfaces, such as polyhedric (i.e. cubic, tetrahedral, etc.) or prismatic, etc. forms. Finally, the body may also have an irregular or random shape, in the case of a gel, combining features of various curved and planar surfaces. Body (106) of FIG. 1C is an example of such an irregular body shape. The particular body shape will be chosen to best match to the biopsy cavity in which the device is placed. However, it is also contemplated that the body shape can be chosen to be considerably larger than the cavity. Therefore, expansion of the device will provide a significant resistance against the walls of the cavity. Moreover, the aspect ratio of the device is not limited to what is displayed in the figures. For example, the cylindrical body (104) may have a shorter or longer length as required.
  • [0048]
    In the bodies of FIGS. 1A and 1C, the generally spherical marker (150) is located at or near the geometric center of the body. Such a configuration will aid the physician in determining the exact location of the biopsy cavity, even after the body degrades and is absorbed into the human or mammalian body.
  • [0049]
    In the case of the ring-shaped markers (154) of FIG. 1B, they are generally aligned along the longitudinal axis (114) of body (104). Note that although the ring-shaped markers (154) are spatially oriented so that the longitudinal axis (114) of the body (104) lies along the longitudinal axes (not shown) of each marker (154), each marker may individually or together assume a wide variety of random or predetermined spatial orientations other than the aligned orientation as seen in FIG. 1C. It can be appreciated that any asymmetric marker such as marker (154) is useful in aiding a physician to determine the spatial orientation of the deployed inventive device.
  • [0050]
    Obviously, marker (150), (154) may reside in locations other than those demonstrated in FIGS. 1A-1C. It is, however, preferred that markers (150), (154) dwell in a predetermined, preferably central, location and orientation in the device body so to aid the physician in determining the location and orientation of the biopsy cavity. The markers herein described may be affixed to the interior or on the surface of the body by any number of suitable methods. For instance, the marker may be merely suspended in the interior of the body (especially in the case where the body is a gel), it may be woven into the body (especially in the case where the marker is a wire or suture), it may be press fit onto the body (especially in the case where the marker is a ring or band), or it may affixed to the body by a biocompatible adhesive. Any suitable means to affix or suspend the marker into the body in the preferred location is within the scope of the present invention.
  • [0051]
    Tissue regrowth in a particular orientation can also be promoted by a body design shown in FIG. 1D. Here, body (110) contains a number of pores (138) through which tissue may grow. The pores may also be aligned in a substantially parallel fashion, traversing the thickness of the body so that tissue may regrow from one side of the body through to the other side. This is demonstrated in inset FIG. 1E, which shows a portion (130) of FIG. 1D in partial longitudinal cross section, complete with pores (138) traversing through the thickness of portion (130). Such pores (138) can be parallel to each other as shown in FIG. 1E, or they may be perpendicularly, radially, or even randomly oriented in the device body.
  • [0052]
    A trio of markers is also shown in FIG. 1D evenly aligned along the body longitudinal axis (140). Barb marker (156), spherical marker (150), and ring-shaped marker (154) demonstrate the use of different multiple markers in a single body (110). As previously described, such a design helps a physician to determine the spatial orientation of the inventive device when it is deployed in a biopsy cavity. Although the barb marker (156) is illustrated in a ‘V’ configuration, it is an important aspect of the barb marker (156) to have a shape that is clearly not spherical. This allows the barb marker (156) to be easily distinguished from calcifications that may be observed during any non-invasive imaging techniques.
  • [0053]
    [0053]FIG. 1F depicts a further embodiment of the present invention in which body (112) is enveloped in a outer shell (142) consisting of a layer of bioabsorbable material such those mentioned above. This configuration allows the perimeter of the biopsy cavity to be marked to avoid exposing the cavity, in the case of a “dirty” margin where re-excision may be necessary, to remaining cancerous cells as the tissue begins to re-grow into the cavity. Such a shell (142) can be radiopaque and/or echogenic in situ, or it may be augmented with an additional coating of an echogenic and/or radiopaque material. The shell (142) can also be made to be palpable so that the physician or patient can be further aided in determining the location and integrity of the implanted inventive device.
  • [0054]
    Shell (142) may be designed to have a varying bioabsorption rate depending upon the thickness and type of material making up the shell (142). In general, the shell can be designed to degrade over a period ranging from as long as a year or more to as little as several months, weeks, or even days. It is preferred that such a bioabsorbable shell be designed to degrade between two and six months; especially preferred is three months. In the design of FIG. 1F, interior (144) of body (112) may be a cross-linked, collagenous material that is readily absorbed by the human or mammalian body once the shell (142) degrades. Interior (144) may be filled with a solid or gelatinous material that can be optionally made radiopaque by any number of techniques herein described.
  • [0055]
    As will be described in additional detail with respect to FIGS. 2A-2F, marker (150) in the device shown in FIG. 1F may be permanently radiopaque or echogenic, or it also may be bioabsorbable and optionally coated with a radiopaque and/or echogenic coating that similarly degrades over a predetermined period of time. It is more important from a clinical standpoint that the marker remain detectable either permanently or, if the patient is uncomfortable with such a scenario, for at least a period of about one to five years so that the physician may follow up with the patient to ensure the health of the tissue in the vicinity of the biopsy cavity. Especially preferable is a marker whose radiopacity or echogenicity lasts from between about one and three years.
  • [0056]
    Each of the bodies depicted in FIG. 1A-1E may be made from a wide variety of solid, liquid, aerosol-spray, spongy, or expanding gelatinous bioabsorbable materials such as collagen, cross-linked collagen, regenerated cellulose, synthetic polymers, synthetic proteins, and combinations thereof. Also contemplated is a body made from a fibrin-collagen matrix, which further prevent unnecessary bleeding, and minimizes the possibility of hematoma formation.
  • [0057]
    Examples of synthetic bioabsorbable polymers that may be used for the body of the device are polyglycolide, or polyglycolic acid (PGA), polylactide, or polylactic acid (PLA), poly ε-caprolactone, polydioxanone, polylactide-co-glycolide, e.g., block or random copolymers of PGA and PLA, and other commercial bioabsorbable medical polymers. Preferred is spongy collagen or cellulose. As mentioned above, materials such as hemostatic and pain-killing substances may be incorporated into the body and marker of the cavity marking device. The use of hemostasis-promoting agents provides an obvious benefit as the device not only marks the site of the biopsy cavity but it aids in healing the cavity as well. Furthermore, such agents help to avoid hematomas. These hemostatic agents may include AVITENE Microfibrillar Collagen Hemostat, ACTIFOAM collagen sponge, sold by C. R. Bard Inc., GELFOAM, manufactured by Upjohn Company, SURGICEL Fibrillar from Ethicon Endosurgeries, Inc., and TISSEEL VH, a surgical fibrin sealant sold by Baxter Healthcare Corp. The device may also be made to emit therapeutic radiation to preferentially treat any suspect tissue remaining in or around the margin of the biopsy cavity. It is envisioned that the marker would be the best vehicle for dispensing such local radiation treatment or similar therapy. Also, the body itself may be. adapted to have radiopaque, echogenic, or other characteristics that allow the body to be located by non-invasive technique without the use of a marker. Such characteristics permit the possibility of locating and substantially identifying the cavity periphery after deployment but prior to absorption of the device. Furthermore, an echogenic coating may be placed over the radiopaque marker to increase the accuracy of locating the marker during ultrasound imaging.
  • [0058]
    FIGS. 2A-2F illustrate various forms of the marker (110). The marker (110) may be in the form of a sphere (150) (FIG. 2A), a hollow sphere (152) (FIG. 2B), a ring or band (154) (FIG. 2C), a barb (156) (FIG. 2D), or a flexible suture or flexible wire (158) (FIG. 2E). Also, the marker may have a distinguishing mark (170) (FIG. 2F). As mentioned above, the barb (156) is illustrated in FIG. 2D as having a “V” shape. The barb (156) is intended to distinguish the marker from calcifications when viewed under non-invasive imaging techniques. As such, the barb (156) is not limited to the “V” shape, rather it has a shape that is easily distinguishable from a spherical or oval calcification.
  • [0059]
    The hollow sphere (152) marker design of FIG. 2B is more susceptible to detection by ultrasound than the solid sphere (150) of FIG. 2A. Such sphere markers (150, 152) can be a silicon bead, for instance. In the case of a ring or band marker (154) seen in FIG. 2C, the body of the cavity marking device may be woven or placed through the band/ring (154). The marker may also be a wire or suture (158) as shown in FIG. 2E and as discussed in greater detail below. In such a case, the marker (158) may be affixed to the exterior perimeter of the body by an adhesive or woven through the body. Another improvement may arise from the marker wire or suture (158) being configured in a particular pattern within the body of the device, e.g., wrapping around the body in a helical manner. Further, the suture or wire marker can be deployed as a loosely wound ball or mass of suture that when deployed into a tissue cavity, fills the cavity. The suture or wire can also looped through the band/ring (154); in this configuration (not shown), the suture or wire can also act as the body of the inventive device. The suture or wire (158) is flexible to facilitate the expansion of the body while in the cavity. In the case of the marker (150) shown in FIG. 2F, distinguishing or identifying mark (170) can be in the form of simple marks as shown, or it may be one or more numbers, letters, symbols, or combinations thereof. These marks (160) are preferably located in more than one location on the marker (150) so that the marker may be readily and simply identified from multiple orientations under a variety of viewing conditions. Such a mark (170) can be used to identify the patient and her condition, provide information about the marker and body of the tissue cavity marking device, provide information about the circumstances and date of the implantation, who performed the procedure, where the procedure was performed, etc. In the case of multiple biopsy sites, this distinguishing mark (170) permits one to differentiate and identify each different site. The mark (170) may be applied via any number of techniques such as physical inscription, physical or plasma deposition, casting, adhesives, etc. The mark (170) may also be an electronic chip providing any necessary information in electronic form that can be remotely detected by appropriate means.
  • [0060]
    An important aspect of the invention is that the marker may be radiopaque, echogenic, mammographic, etc. so that it can be located by non-invasive techniques. Such a feature can be an inherent property of the material used for the marker. Alternatively, a coating or the like can be added to the marker to render the marker detectable or to enhance its detectability. For radiopacity, the marker may be made of a non-bioabsorbable radiopaque material such as platinum, platinum-iridium, platinum-nickel, platinum-tungsten, gold, silver, rhodium, tungsten, tantalum, titanium, nickel, nickel-titanium, their alloys, and stainless steel or any combination of these metals. By mammographic we mean that the component described is visible under radiography or any other traditional or advanced mammography technique in which breast tissue is imaged.
  • [0061]
    As previously discussed, the marker can alternatively be made of or coated with a bioabsorbable material. In this case, the marker can, for instance, be made from an additive-loaded polymer. The additive is a radiopaque, echogenic, or other type of substance that allows for the non-invasive detection of the marker. In the case of radiopaque additives, elements such as barium- and bismuth-containing compounds, as well as particulate radio-opaque fillers, e.g., powdered tantalum or tungsten, barium carbonate, bismuth oxide, barium sulfate, etc. are preferred. To aid in detection by ultrasound or similar imaging techniques, any component of the device may be combined with an echogenic coating. One such coating is ECHO-COAT from STS Biopolymers. Such coatings contain echogenic features which provide the coated item with an acoustically reflective interface and a large acoustical impedance differential. As stated above, an echogenic coating may be placed over a radiopaque marker to increase the accuracy of locating the marker during ultrasound imaging.
  • [0062]
    Note that the radiopacity and echogenicity described herein for the marker and the body are not mutually exclusive. It is within the scope of the present invention for the marker or the body to be radiopaque but not necessarily echogenic, and for the marker or the body to be echogenic but not necessarily radiopaque. It is also within the scope of the invention that the marker and the body are both capable of being simultaneously radiopaque and echogenic. For example, if a platinum ring marker were coated with an echogenic coating, such a marker would be readily visible under x-ray and ultrasonic energy. A similar configuration can be envisioned for the body or for a body coating.
  • [0063]
    The marker is preferably large enough to be readily visible to the physician under x-ray or ultrasonic viewing, for example, yet be small enough to be able to be percutaneously deployed into the biopsy cavity and to not cause any difficulties with the patient. More specifically, the marker will not be large enough to be palpable or felt by the patient.
  • [0064]
    Another useful version of the invention is shown in FIG. 3A. In this device, there are several cylindrical body members (302); however, there is no limit to the number of body members that can make up the device. The body members (302) can individually or together take on a variety of sizes and shapes as discussed above depending on the characteristics of the biopsy cavity to be filled. The body members (302) may uniformly or in combination be made of one or more materials suitable for use in a biopsy cavity as previously described.
  • [0065]
    Here one or more markers may traverse two or more body member segments through the interior of the body members (302) as shown in FIG. 3A. Here, markers (318) are located substantially parallel to the longitudinal axis (320) of each right cylindrical body member (302) in their interior, connecting each body member (302) while marking their geometric center as between the markers. Such a marker (318) may be used in conjunction with the other markers as described above and may also be accompanied by one or more additional markers arranged randomly or in a predetermined pattern to variously mark particular sections of the device. Alternately, such a marker may, singly or in combination with other markers, be affixed on or near the surface of the sponge so as to mark the perimeter of the body member (302).
  • [0066]
    course, when used in conjunction with other connecting markers, marker (318) need not necessarily connect each body member; it may be used solely to indicate the orientation or location of each individual sponge or the entire device, depending on the material, geometry, size, orientation, etc. of marker (318). When not used in this connecting function, therefore, marker (318) need not traverse two body members (302) as shown in FIG. 3A.
  • [0067]
    A variety of patterns can be envisioned in which all or part of the perimeter of the sponge body is marked. For example, a marker (322) can wrap around the body (302) in a helical pattern (FIG. 3B), or it can be used in conjunction with other markers (324) in a pattern parallel to the longitudinal axis (320) of the body (302) (FIG. 3C). Another useful perimeter marking pattern is shown in FIG. 3D, where marker segments (326) are affixed at or near the surface of the circular bases of the cylindrical body (302) in a cross pattern, indicating the ends of the sponge and their center. As seen from the figures, the marker(s) may, but do not necessarily, have some texture. Any marker pattern, internal or external to the body, is within the scope of the present invention. For the applications depicted in FIGS. 3A-3D, it is preferred that the marker be a radiopaque or echogenic wire or suture.
  • [0068]
    Another possible configuration is obtained by combining the suture or wire markers (158) in a body with any other type marker (150, 152, 154, or 156) or vice versa. For example, in FIG. 3B, a spherical marker (150) may be placed in the center of the cylindrical body (302.) Therefore, the cylindrical body (302) would contain the suture or wire marker (322) wrapped helically adjacent to the outer perimeter, and a marker (150) would be placed in the center of the cylindrical body (302). Such a combination may be obtained with any of the body and marker configurations as defined above.
  • [0069]
    Also, turning back to the marking device (100) in FIG. 1A or the marking device (100) of FIG. 11B, the markers (150 or 154) maybe substituted with one or more suture or wire markers (158) preferably, but not exclusively, extending through the center and pointing radially away from the center. This configuration allows marking of the cavity perimeter and establishing of the directionality of the cavity itself.
  • [0070]
    Any of the previously-described additional features of the inventive device, such as presence of pain-killing or hemostatic drugs, the capacity for the marker to emit therapeutic radiation for the treatment of various cancers, the various materials that may make up the marker and body, as well as their size, shape, orientation, geometry, etc. may be incorporated into the device described above in conjunction with FIGS. 3A-3D.
  • [0071]
    Turning now to FIGS. 4A-4C, a method of delivering the inventive device of FIG. 1 A is shown. FIG. 4A details the marking device (402) just prior to delivery into a tissue cavity (404) of human or other mammalian tissue, preferably breast tissue (406). As can be seen, the step illustrated in FIG. 4A shows a suitable tubular percutaneous access device (400), such as a catheter or delivery tube, with a distal end (408) disposed in the interior of cavity (404). As previously described, the marking device (402) may be delivered percutaneously through the same access device (400) used to perform the biopsy in which tissue was removed from cavity (404). Although this is not necessary, it is less traumatic to the patient and allows more precise placement of the marking device (402) before fluid begins to fill the cavity (400).
  • [0072]
    In FIG. 4B, marking device (402) is shown being pushed out of the distal end (408) of access device (400) by a pusher (412) and resiliently expanding to substantially fill the tissue cavity (404).
  • [0073]
    Finally, in FIG. 4C, access device (400) is withdrawn from the breast tissue, leaving marking device (402) deployed to substantially fill the entire cavity (404) with radiopaque or echogenic marker (410) suspended in the geometric center of the marking device (402) and the cavity (404). As mentioned above, the marking device (402) may be sized to be larger than the cavity (404) thus providing a significant resistance against the walls of the cavity (404).
  • [0074]
    FIGS. 4D-4F show a method of delivering the marking device (402) into a tissue cavity (404) by a plunger (414) that is capable of both advancing the marking device (402) and delivering a bio-compatible fluid (416). The “bio-compatible fluid” is a liquid, solution, or suspension that may contain inorganic or organic material. The fluid (416) is preferably a saline solution, but may be water or contain adjuvants such as medications to prevent infection, reduce pain, or the like. Obviously, the fluid (416) is intended to be a type that does no harm to the body.
  • [0075]
    [0075]FIG. 4D details the marking device (402) prior to delivery into the tissue cavity (404). In FIG. 4E, a plunger (414) pushes the marking device (402) out of the access device (400). Upon. exiting the access device (400) the marking device (402) begins resiliently expanding to substantially fill the cavity (404).
  • [0076]
    [0076]FIG. 4F shows the plunger (414) delivering the bio-compatible fluid (416) into the cavity (404). The fluid (416) aids the marking device (402) in expanding to substantially fill the cavity (404). In this example, the bio-compatible fluid (416) is delivered subsequent to the placement of the marking device (402) in the cavity (404). The marking device (402) may also be soaked with fluid (416) prior to placement in the cavity (404).
  • [0077]
    FIGS. 4G-41 show another method of delivering the marking device (402) into the tissue cavity (404) by using the bio-compatible fluid (416) as the force to deliver the marking device (402) into the tissue cavity (404).
  • [0078]
    [0078]FIG. 4G details the marking device (402) prior to delivery into the tissue cavity (404). FIG. 4H illustrates flow of the bio-compatible fluid (416) in the access device (400), the fluid (416) flow then pushes the marking device (402) out of the access device (400).
  • [0079]
    [0079]FIG. 41 shows the delivery device (400) continuing to deliver the bio-compatible fluid (416) into the cavity (404). The fluid (416) aids the marking device (402) in expanding to substantially fill the cavity (404). In this example, the bio-compatible fluid (416) is delivered after the placement of the marking device (402) in the cavity (404) although the invention is not limited to the continued delivery of the fluid (416).
  • [0080]
    [0080]FIG. 4J-4K shows the method of delivering the body (418) of the cavity marking device directly into the cavity (404) prior to the placement of the marker (410) in the device (402).
  • [0081]
    [0081]FIG. 4J shows the deposit of the body material (418) into the cavity (404). In this case the body material (418) may be a gel type material as described above. FIG. 4K details the filling of the cavity (404) with the body material (418). At this point, the delivery device (not shown in FIG. 4K) may be withdrawn. FIG. 4L details the placement of the marker (410) into the body material (418).
  • [0082]
    FIGS. 5A-5E show yet another version of the invention in which a marker, preferably consisting of a radiopaque or echogenic wire, is deployed alone into a tissue cavity without the use of any body. In this device, the marker can be made of a shape memory material, such as a nickel-titanium alloy, which when deployed into the biopsy cavity, assumes a predetermined configuration to substantially fill the cavity, mark the cavity location and margin, and indicate the orientation of the marker inside the cavity.
  • [0083]
    In FIG. 5A, marker (500) is a three-dimensional sphere consisting of two rings (502), (504) pivotally connected at ends (506), (508) so to assume a spherical shape. Such a marker can be made of a shape memory metal so that when it is placed in a deployment tube (510) shown in FIG. 5B, marker (500) assumes a collapsed profile suitable for deployment through tube (510) by pusher (512). Upon exiting into the tissue cavity (not shown), marker (500) assumes the spherical shape of FIG. 5A to fill the cavity. The marker (500) may also be shaped into any similar shape such as an ellipsoidal shape.
  • [0084]
    Turning now to FIG. 5C, a marker (520) in the form of a wire cylinder is shown. Again, this device is structurally configured to assume the depicted cylindrical configuration when deployed in the tissue cavity, but may be (as described above) “collapsed” into a deployment tube for percutaneous delivery. This device is especially suitable for marking the distal and proximal ends of the tissue cavity due to its asymmetrical shape.
  • [0085]
    [0085]FIG. 5D shows a shape memory marker (530) in the form of a helical coil deployed into tissue cavity (532). Again, as seen in FIG. SE, such a marker (530) may be deployed through delivery tube (510) by pusher (512) in a substantially elongated, straightened form, only to substantially assume the shape of the cavity (532) as shown in FIG. 5D. Any suitable delivery device or pusher (512) capable of deploying marker (530) into cavity (532) is within the scope of this invention.
  • [0086]
    Each of the markers shown in FIGS. 5A-5E is preferably a shape memory material coated or supplemented with a radiopacity-enhancing material, such as gold, platinum, or any other radiopaque material herein discussed. The markers may singly, or in combination with being radiopaque, be echogenic or be made echogenic by any of the materials or methods herein described.
  • [0087]
    From the foregoing, it is understood that the invention provides an improved subcutaneous cavity marking device and method. While the above descriptions have described the invention for use in the marking of biopsy cavities, the invention is not limited to such. One such application is evident as the invention may further be used as a lumpectomy site marker. In this use, the cavity marking device yield an improved benefit by marking the perimeter of the lumpectomy cavity.
  • [0088]
    The invention herein has been described by examples and a particularly desired way of practicing the invention has been described. However, the invention as claimed herein is not limited to that specific description in any manner. Equivalence to the description as hereinafter claimed is considered to be within the scope of protection of this patent.

Claims (66)

    We claim as our invention:
  1. 1. A subcutaneous cavity marking device comprising:
    (a) at least one filler body comprising a resilient bioabsorbable material, and
    (b) at least one marker.
  2. 2. The device of claim 1 wherein the at least one marker comprises a non-bioabsorbable material.
  3. 3. The device of claim 2 wherein the marker comprises a material selected from the group consisting of platinum, iridium, nickel, tungsten, tantalum, gold, silver, rhodium, titanium, alloys thereof, and stainless steel.
  4. 4. The device of claim 1 wherein the at least one marker comprises a second bioabsorbable material.
  5. 5. The device of claim 4 wherein the second bioabsorbable material comprises a polymer having a radiopaque additive.
  6. 6. The device of claim 5 wherein the radiopaque additive is selected from the group consisting of barium-containing compounds, bismuth-containing compounds, powdered tantalum, powdered tungsten, barium carbonate, bismuth oxide, and barium sulfate.
  7. 7. The device of claim 1 wherein the at least one marker is radiopaque.
  8. 8. The device of claim 1 wherein the at least one body is radiopaque.
  9. 9. The device of claim 1 wherein the at least one marker is echogenic.
  10. 10. The device of claim 1 wherein the at least one body is echogenic.
  11. 11. The device of claim 1 wherein the at least one marker is mammographic.
  12. 12. The device of claim 1 wherein the at least one body is mammographic.
  13. 13. The device of claim 1 wherein the at least one body is palpable.
  14. 14. The device of claim 1 wherein the marker is located within an interior of the at least one body.
  15. 15. The device of claim 1 wherein the marker is substantially located within a geometric center of the at least one body.
  16. 16. The device of claim 1 additionally comprising a pain killing substance.
  17. 17. The device of claim 1 additionally comprising a hemostatic substance.
  18. 18. The device of claim 1 wherein the bioabsorbable material is selected from the group consisting of collagen, regenerated cellulose, synthetic polymers and synthetic proteins.
  19. 19. The device of claim 1 wherein the marker has a form of a sphere.
  20. 20. The device of claim 19 wherein the sphere is hollow.
  21. 21. The device of claim 1 wherein the marker has a form of a band.
  22. 22. The device of claim 1 wherein the marker comprises a suture.
  23. 23. The device of claim 1 wherein the marker comprises a wire.
  24. 24. The device of claim 1 wherein the marker has a distinguishing mark.
  25. 25. The device of claim 1 wherein the marker is fixedly attached to the at least one body.
  26. 26. The device of claim 25 wherein the marker is woven to the at least one body.
  27. 27. The device of claim 1 wherein the marker is radioactive.
  28. 28. The device of claim 1 wherein the at least one body is radioactive.
  29. 29. The device of claim 1 wherein the at least one body is substantially spherical.
  30. 30. The device of claim 1 wherein the at least one body is substantially cylindrical.
  31. 31. The device of claim 1 wherein the at least one body is has a substantially irregular shape.
  32. 32. The device of claim 1 wherein the at least one body is a biocompatible gel.
  33. 33. The device of claim 1 wherein the at least one body comprises a plurality of pores.
  34. 34. The device of claim 1 wherein the pores are configured to promote tissue growth in a preferred orientation.
  35. 35. The device of claim 1 wherein the at least one filler body additionally comprises a bio-compatible liquid.
  36. 36. A subcutaneous cavity marking device comprising a plurality of resilient bioabsorbable filler bodies, at least two of which are connected by at least one marker.
  37. 37. The device of claim 36 wherein the at least one marker is suspended through the interior of at least one of the plurality of filler bodies.
  38. 38. The device of claim 36 wherein the at least one marker is attached substantially to an outer perimeter of at least one of the plurality of bodies.
  39. 39. A method of marking a tissue cavity comprising the steps of:
    (a) suspending a marker within at least one filler body of resilient bioabsorbable material, and
    (b) inserting the at least one filler body into the cavity.
  40. 40. The method of claim 39 wherein the step of inserting the at least one filler body into the cavity is performed percutaneously.
  41. 41. The method of claim 40 wherein the at least one filler body additionally comprises a hemostatic substance.
  42. 42. The method of claim 40 wherein the at least one filler body additionally comprises a pain-killing substance.
  43. 43. The method of claim 40 wherein the marker is radiopaque.
  44. 44. The method of claim 40 wherein the marker is echogenic.
  45. 45. The method of claim 40 wherein the at least one body is radiopaque.
  46. 46. The method of claim 40 wherein the at least one body is echogenic.
  47. 47. The method of claim 40 wherein the marker is fixedly attached to the at least one body.
  48. 48. The method of claim 39 wherein the step of inserting the at least one filler body into the cavity is performed surgically.
  49. 49. The method of claim 39 wherein the step of inserting the at least one filler body of resilient bioabsorbable material into the cavity is performed prior to the step of suspending the marker within the filler body.
  50. 50. A method of marking a tissue cavity having a margin in a mammalian body, comprising:
    (a) subcutaneously accessing the cavity via a delivery device,
    (b) deploying a remotely detectable marker having a predetermined shape through the delivery device into the cavity,
    wherein upon delivery into the cavity the marker assumes a predetermined three-dimensional configuration so to (1) substantially fill the cavity, (2) mark the cavity margin, and (3) indicate the orientation of the marker inside the cavity.
  51. 51. The method of claim 50 wherein the marker is bioabsorbable.
  52. 52. The method of claim 50 wherein the marker is radiopaque.
  53. 53. The method of claim 50 wherein the marker is echogenic.
  54. 54. The method of claim 50 wherein the marker comprises a wire.
  55. 55. The method of claim 50 wherein the marker comprises a material selected from the group consisting of platinum, iridium, nickel, tungsten, tantalum, gold, silver, rhodium, titanium, alloys thereof, and stainless steel.
  56. 56. The method of claim 50 wherein the marker is capable of emitting radioactive energy.
  57. 57. The method of claim 50 wherein the marker is a helical coil.
  58. 58. The method of claim 50 wherein the marker defines a volume having a substantially spherical shape when the marker is deployed inside the cavity.
  59. 59. The method of claim 50 wherein the marker defines a volume comprising a substantially cylindrical shape when the marker is deployed inside the cavity.
  60. 60. The method of claim 50 wherein the marker defines a volume comprising a random shape when the marker is deployed inside the cavity.
  61. 61. The method of claim 50 wherein the wire comprises a shape memory material.
  62. 62. The method of claim 50 further comprising the step of introducing a bio-compatible liquid in the marker prior to the step of deploying the marker.
  63. 63. The method of claim 62 wherein the delivery device uses a hydraulic force to deploy the marker.
  64. 64. The method of claim 50 further comprising the step of introducing a biocompatible liquid in the marker subsequent to the step of deploying the marker.
  65. 65. The method of claim 64 wherein the bio-compatible liquid is introduced to the marker via the delivery device.
  66. 66. A method of marking a tissue cavity comprising the steps of:
    (a) inserting the at least one filler body into the cavity, and
    (b) suspending a marker within at least one filler body of resilient bioabsorbable material, and
US10114712 1998-12-24 2002-04-01 Subcutaneous cavity marking device and method Abandoned US20020107437A1 (en)

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US22061898 true 1998-12-24 1998-12-24
US09285329 US6356782B1 (en) 1998-12-24 1999-04-02 Subcutaneous cavity marking device and method
US09805652 US8320993B2 (en) 1998-12-24 2001-03-13 Subcutaneous cavity marking device
US10114712 US20020107437A1 (en) 1998-12-24 2002-04-01 Subcutaneous cavity marking device and method

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US10114712 US20020107437A1 (en) 1998-12-24 2002-04-01 Subcutaneous cavity marking device and method
US10960618 US8320994B2 (en) 1998-12-24 2004-10-06 Biopsy cavity marking device and method
US10960622 US20050059888A1 (en) 1998-12-24 2004-10-06 Biopsy cavity marking device and method
US10961491 US7668582B2 (en) 1998-12-24 2004-10-07 Biopsy site marker
US10961979 US20050080339A1 (en) 1998-12-24 2004-10-08 Biopsy cavity marking device
US10961581 US20050080338A1 (en) 1998-12-24 2004-10-08 Biopsy cavity marking device and method
US11241500 US8306602B2 (en) 1998-12-24 2005-09-30 Biopsy cavity marking device
US11283310 US20060079770A1 (en) 1998-12-24 2005-11-18 Biopsy site marker

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US09805652 Continuation US8320993B2 (en) 1998-12-24 2001-03-13 Subcutaneous cavity marking device

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US10960622 Continuation US20050059888A1 (en) 1998-12-24 2004-10-06 Biopsy cavity marking device and method
US10960618 Continuation US8320994B2 (en) 1998-12-24 2004-10-06 Biopsy cavity marking device and method
US10961491 Continuation US7668582B2 (en) 1998-12-24 2004-10-07 Biopsy site marker
US10961979 Continuation US20050080339A1 (en) 1998-12-24 2004-10-08 Biopsy cavity marking device
US10961581 Continuation US20050080338A1 (en) 1998-12-24 2004-10-08 Biopsy cavity marking device and method

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US20020107437A1 true true US20020107437A1 (en) 2002-08-08

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US09285329 Active - Reinstated US6356782B1 (en) 1998-12-24 1999-04-02 Subcutaneous cavity marking device and method
US09805652 Active 2023-07-20 US8320993B2 (en) 1998-12-24 2001-03-13 Subcutaneous cavity marking device
US10114712 Abandoned US20020107437A1 (en) 1998-12-24 2002-04-01 Subcutaneous cavity marking device and method
US10960618 Active 2021-02-06 US8320994B2 (en) 1998-12-24 2004-10-06 Biopsy cavity marking device and method
US10960622 Abandoned US20050059888A1 (en) 1998-12-24 2004-10-06 Biopsy cavity marking device and method
US10961491 Active 2020-12-05 US7668582B2 (en) 1998-12-24 2004-10-07 Biopsy site marker
US10961979 Pending US20050080339A1 (en) 1998-12-24 2004-10-08 Biopsy cavity marking device
US10961581 Abandoned US20050080338A1 (en) 1998-12-24 2004-10-08 Biopsy cavity marking device and method
US11241500 Active 2023-08-03 US8306602B2 (en) 1998-12-24 2005-09-30 Biopsy cavity marking device
US11283310 Abandoned US20060079770A1 (en) 1998-12-24 2005-11-18 Biopsy site marker
US13604111 Abandoned US20130066195A1 (en) 1998-12-24 2012-09-05 Device and method for safe location and marking of a cavity and sentinel lymph nodes
US13604158 Active US8600481B2 (en) 1998-12-24 2012-09-05 Subcutaneous cavity marking device
US14067270 Abandoned US20140051996A1 (en) 1998-12-24 2013-10-30 Subcutaneous cavity marking device and method
US14185097 Active US9380998B2 (en) 1998-12-24 2014-02-20 Subcutaneous cavity marking device and method

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US10960618 Active 2021-02-06 US8320994B2 (en) 1998-12-24 2004-10-06 Biopsy cavity marking device and method
US10960622 Abandoned US20050059888A1 (en) 1998-12-24 2004-10-06 Biopsy cavity marking device and method
US10961491 Active 2020-12-05 US7668582B2 (en) 1998-12-24 2004-10-07 Biopsy site marker
US10961979 Pending US20050080339A1 (en) 1998-12-24 2004-10-08 Biopsy cavity marking device
US10961581 Abandoned US20050080338A1 (en) 1998-12-24 2004-10-08 Biopsy cavity marking device and method
US11241500 Active 2023-08-03 US8306602B2 (en) 1998-12-24 2005-09-30 Biopsy cavity marking device
US11283310 Abandoned US20060079770A1 (en) 1998-12-24 2005-11-18 Biopsy site marker
US13604111 Abandoned US20130066195A1 (en) 1998-12-24 2012-09-05 Device and method for safe location and marking of a cavity and sentinel lymph nodes
US13604158 Active US8600481B2 (en) 1998-12-24 2012-09-05 Subcutaneous cavity marking device
US14067270 Abandoned US20140051996A1 (en) 1998-12-24 2013-10-30 Subcutaneous cavity marking device and method
US14185097 Active US9380998B2 (en) 1998-12-24 2014-02-20 Subcutaneous cavity marking device and method

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Cited By (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050019262A1 (en) * 2003-07-25 2005-01-27 Rubicor Medical, Inc. Post-biopsy cavity treatment implants and methods
US20050033157A1 (en) * 2003-07-25 2005-02-10 Klein Dean A. Multi-modality marking material and method
US20050038355A1 (en) * 2003-08-13 2005-02-17 Gellman Barry N. Marking biopsy sites
US20050234336A1 (en) * 2004-03-26 2005-10-20 Beckman Andrew T Apparatus and method for marking tissue
US20050273002A1 (en) * 2004-06-04 2005-12-08 Goosen Ryan L Multi-mode imaging marker
US20060009844A1 (en) * 2004-06-18 2006-01-12 Aesculap Ag & Co. Kg Implant
US20060258933A1 (en) * 2005-05-10 2006-11-16 Advanced Clinical Solutions, Inc. Method of defining a biological target for treatment
US20070110665A1 (en) * 2005-11-17 2007-05-17 Bolan Patrick J Tissue marker for multimodality radiographic imaging
US20070135711A1 (en) * 2003-07-25 2007-06-14 Rubicor Medical, Inc. Methods and systems for marking post biopsy cavity sites
US20070299339A1 (en) * 2003-07-25 2007-12-27 Rubicor Medical, Inc. Post-biopsy cavity treatment implants and methods
US20080306590A1 (en) * 2004-01-29 2008-12-11 Smart Implant Plc Prosthesis and Method of Manufacturing a Prosthesis
US20090149746A1 (en) * 2007-11-19 2009-06-11 Rubicor Medical, Inc. Post-biopsy cavity treatment implants and methods
US20090216115A1 (en) * 2004-07-23 2009-08-27 Calypso Medical Technologies, Inc. Anchoring wirless markers within a human body
US20090221913A1 (en) * 2008-03-03 2009-09-03 Ethicon Endo-Surgery, Inc. Intraluminal tissue markers
US7668582B2 (en) * 1998-12-24 2010-02-23 Ethicon Endo-Surgery, Inc. Biopsy site marker
US7819820B2 (en) 2003-11-17 2010-10-26 Bard Peripheral Vascular, Inc. Self contained, self piercing, side-expelling marking apparatus
US20110160577A1 (en) * 2004-02-06 2011-06-30 Olympus Corporation Light marker for indwelt use in patients body and for identification of lesions inside patients tubular organ using the light marker
US8052708B2 (en) 1999-06-17 2011-11-08 Bard Peripheral Vascular, Inc. Apparatus for the percutaneous marking of a lesion
US8064987B2 (en) 2006-10-23 2011-11-22 C. R. Bard, Inc. Breast marker
US8157862B2 (en) 1997-10-10 2012-04-17 Senorx, Inc. Tissue marking implant
US8177792B2 (en) 2002-06-17 2012-05-15 Senorx, Inc. Plugged tip delivery tube for marker placement
US8219182B2 (en) 1999-02-02 2012-07-10 Senorx, Inc. Cavity-filling biopsy site markers
US8224424B2 (en) 1999-02-02 2012-07-17 Senorx, Inc. Tissue site markers for in vivo imaging
JP2012139509A (en) * 2002-10-11 2012-07-26 Ion Beam Applications Sa Interstitial marker and device for visualizing the marker through imaging modality
US8292822B2 (en) 1998-06-22 2012-10-23 Devicor Medical Products, Inc. Biopsy localization method and device
US8311610B2 (en) 2008-01-31 2012-11-13 C. R. Bard, Inc. Biopsy tissue marker
US8361082B2 (en) 1999-02-02 2013-01-29 Senorx, Inc. Marker delivery device with releasable plug
US8401622B2 (en) 2006-12-18 2013-03-19 C. R. Bard, Inc. Biopsy marker with in situ-generated imaging properties
US8419656B2 (en) 2004-11-22 2013-04-16 Bard Peripheral Vascular, Inc. Post decompression marker introducer system
US8447386B2 (en) 2003-05-23 2013-05-21 Senorx, Inc. Marker or filler forming fluid
US8486028B2 (en) 2005-10-07 2013-07-16 Bard Peripheral Vascular, Inc. Tissue marking apparatus having drug-eluting tissue marker
US8498693B2 (en) 1999-02-02 2013-07-30 Senorx, Inc. Intracorporeal marker and marker delivery device
US8626269B2 (en) 2003-05-23 2014-01-07 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US8670818B2 (en) 2008-12-30 2014-03-11 C. R. Bard, Inc. Marker delivery device for tissue marker placement
US8668737B2 (en) 1997-10-10 2014-03-11 Senorx, Inc. Tissue marking implant
US8718745B2 (en) 2000-11-20 2014-05-06 Senorx, Inc. Tissue site markers for in vivo imaging
USD715442S1 (en) 2013-09-24 2014-10-14 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715942S1 (en) 2013-09-24 2014-10-21 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716450S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716451S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
US9149341B2 (en) 1999-02-02 2015-10-06 Senorx, Inc Deployment of polysaccharide markers for treating a site within a patient
US9327061B2 (en) 2008-09-23 2016-05-03 Senorx, Inc. Porous bioabsorbable implant
US9492570B2 (en) 1998-12-24 2016-11-15 Devicor Medical Products, Inc. Device and method for safe location and marking of a biopsy cavity
US9579077B2 (en) 2006-12-12 2017-02-28 C.R. Bard, Inc. Multiple imaging mode tissue marker
US9669113B1 (en) 1998-12-24 2017-06-06 Devicor Medical Products, Inc. Device and method for safe location and marking of a biopsy cavity
US9795455B2 (en) 2014-08-22 2017-10-24 Breast-Med, Inc. Tissue marker for multimodality radiographic imaging
US9820824B2 (en) 1999-02-02 2017-11-21 Senorx, Inc. Deployment of polysaccharide markers for treating a site within a patent
US9943704B1 (en) 2009-01-21 2018-04-17 Varian Medical Systems, Inc. Method and system for fiducials contained in removable device for radiation therapy

Families Citing this family (172)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0781114B1 (en) * 1994-09-16 2005-05-25 Ethicon Endo-Surgery, Inc. Devices for defining and marking tissue
US20020058882A1 (en) * 1998-06-22 2002-05-16 Artemis Medical, Incorporated Biopsy localization method and device
US8288745B2 (en) * 1997-10-10 2012-10-16 Senorx, Inc. Method of utilizing an implant for targeting external beam radiation
DE69839888D1 (en) * 1997-11-12 2008-09-25 Genesis Technologies Llc A device for removing occlusions in biological passages
US9498604B2 (en) 1997-11-12 2016-11-22 Genesis Technologies Llc Medical device and method
US20100030256A1 (en) 1997-11-12 2010-02-04 Genesis Technologies Llc Medical Devices and Methods
US20040010206A1 (en) * 1998-02-10 2004-01-15 Dubrul William R. Intraoperative tissue treatment methods
US6602204B2 (en) * 1998-02-10 2003-08-05 Artemis Medical, Inc Intraoperative tissue treatment methods
US20010045575A1 (en) * 1998-05-01 2001-11-29 Mark Ashby Device and method for facilitating hemostasis of a biopsy tract
US6496717B2 (en) * 1998-10-06 2002-12-17 University Of South Florida Radio guided seed localization of imaged lesions
US8114006B2 (en) * 1998-10-06 2012-02-14 University Of South Florida Radio guided seed localization of imaged lesions
US8177762B2 (en) 1998-12-07 2012-05-15 C. R. Bard, Inc. Septum including at least one identifiable feature, access ports including same, and related methods
US6161034A (en) * 1999-02-02 2000-12-12 Senorx, Inc. Methods and chemical preparations for time-limited marking of biopsy sites
US6347241B2 (en) * 1999-02-02 2002-02-12 Senorx, Inc. Ultrasonic and x-ray detectable biopsy site marker and apparatus for applying it
US6782289B1 (en) * 1999-10-08 2004-08-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and apparatus for characterizing lesions in blood vessels and other body lumens
US6571116B2 (en) * 2000-05-09 2003-05-27 Imaging Diagnostic Systems, Inc. Medical optical imaging scanner using multiple wavelength simultaneous data acquisition for breast imaging
US6635064B2 (en) * 2000-10-04 2003-10-21 Macropore Biosurgery, Inc. Non-scatterable, radio-opaque material for medical imaging applications
US6632235B2 (en) * 2001-04-19 2003-10-14 Synthes (U.S.A.) Inflatable device and method for reducing fractures in bone and in treating the spine
US6855153B2 (en) * 2001-05-01 2005-02-15 Vahid Saadat Embolic balloon
GB0120645D0 (en) 2001-08-24 2001-10-17 Smiths Group Plc Medico-surgical devices
US6648862B2 (en) 2001-11-20 2003-11-18 Spheric Products, Ltd. Personally portable vacuum desiccator
EP1467661A4 (en) * 2001-12-19 2008-11-05 Nmt Medical Inc Septal occluder and associated methods
US7318833B2 (en) 2001-12-19 2008-01-15 Nmt Medical, Inc. PFO closure device with flexible thrombogenic joint and improved dislodgement resistance
US7280865B2 (en) * 2001-12-20 2007-10-09 Accuray Incorporated Anchored fiducial apparatus and method
EP1471835A4 (en) * 2002-01-14 2008-03-19 Nmt Medical Inc Patent foramen ovale (pfo) closure method and device
EP1487353A4 (en) * 2002-03-25 2008-04-16 Nmt Medical Inc Patent foramen ovale (pfo) closure clips
CA2488337A1 (en) 2002-06-05 2003-12-18 Nmt Medical, Inc. Patent foramen ovale (pfo) closure device with radial and circumferential support
US7670350B2 (en) * 2002-08-01 2010-03-02 Selis James E Biopsy devices and methods
US7766820B2 (en) 2002-10-25 2010-08-03 Nmt Medical, Inc. Expandable sheath tubing
EP1562653A1 (en) * 2002-11-06 2005-08-17 NMT Medical, Inc. Medical devices utilizing modified shape memory alloy
US6994712B1 (en) * 2002-11-12 2006-02-07 Biopsy Sciences, Llc Bioabsorbable marker having external anchoring means
EP2110094B1 (en) 2002-11-18 2012-06-27 Bard Peripheral Vascular, Inc. Apparatus and method for implanting a preloaded localization wire
US7695446B2 (en) * 2002-12-02 2010-04-13 Gi Dynamics, Inc. Methods of treatment using a bariatric sleeve
US7678068B2 (en) * 2002-12-02 2010-03-16 Gi Dynamics, Inc. Atraumatic delivery devices
CA2512203C (en) 2002-12-02 2012-10-23 Gi Dynamics, Inc. Bariatric sleeve
US7025791B2 (en) * 2002-12-02 2006-04-11 Gi Dynamics, Inc. Bariatric sleeve
US7608114B2 (en) * 2002-12-02 2009-10-27 Gi Dynamics, Inc. Bariatric sleeve
US20070032879A1 (en) * 2002-12-02 2007-02-08 Levine Andy H Anti-buckling sleeve
US9017373B2 (en) * 2002-12-09 2015-04-28 W.L. Gore & Associates, Inc. Septal closure devices
US7976452B2 (en) * 2003-06-11 2011-07-12 L.Vad Technology, Inc. Long term ambulatory intro-aortic balloon pump with percutaneous access device
EP1610719B1 (en) * 2003-03-28 2010-01-13 GI Dynamics, Inc. Sleeve for delayed introduction of enzymes into the intestine
US20040220682A1 (en) * 2003-03-28 2004-11-04 Gi Dynamics, Inc. Anti-obesity devices
US20050119562A1 (en) * 2003-05-23 2005-06-02 Senorx, Inc. Fibrous marker formed of synthetic polymer strands
US7783336B2 (en) 2003-06-06 2010-08-24 Ethicon Endo-Surgery, Inc. Subcutaneous biopsy cavity marker device
US20050010231A1 (en) * 2003-06-20 2005-01-13 Myers Thomas H. Method and apparatus for strengthening the biomechanical properties of implants
US20040260201A1 (en) * 2003-06-23 2004-12-23 Mueller Richard L. Cytology brush with releasable end portion
US9861346B2 (en) * 2003-07-14 2018-01-09 W. L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
US8480706B2 (en) 2003-07-14 2013-07-09 W.L. Gore & Associates, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
ES2428967T3 (en) * 2003-07-14 2013-11-12 W.L. Gore & Associates, Inc. tubular closure device patent foramen ovale (PFO) retention system
CA2536368A1 (en) * 2003-08-19 2005-03-03 Nmt Medical, Inc. Expandable sheath tubing
US20050065484A1 (en) * 2003-09-10 2005-03-24 Watson Richard L. Wound healing apparatus with bioabsorbable material and suction tubes
US20050273119A1 (en) 2003-12-09 2005-12-08 Nmt Medical, Inc. Double spiral patent foramen ovale closure clamp
US8057420B2 (en) 2003-12-09 2011-11-15 Gi Dynamics, Inc. Gastrointestinal implant with drawstring
EP1708641A1 (en) 2003-12-09 2006-10-11 GI Dynamics, Inc. Intestinal sleeve
US20050148963A1 (en) * 2004-01-05 2005-07-07 Brennan H. G. Bioabsorbable surgical sponge
US7871419B2 (en) * 2004-03-03 2011-01-18 Nmt Medical, Inc. Delivery/recovery system for septal occluder
US7657298B2 (en) * 2004-03-11 2010-02-02 Stryker Leibinger Gmbh & Co. Kg System, device, and method for determining a position of an object
US7790945B1 (en) 2004-04-05 2010-09-07 Kci Licensing, Inc. Wound dressing with absorption and suction capabilities
US20050267524A1 (en) * 2004-04-09 2005-12-01 Nmt Medical, Inc. Split ends closure device
US8361110B2 (en) * 2004-04-26 2013-01-29 W.L. Gore & Associates, Inc. Heart-shaped PFO closure device
US8308760B2 (en) * 2004-05-06 2012-11-13 W.L. Gore & Associates, Inc. Delivery systems and methods for PFO closure device with two anchors
US7842053B2 (en) 2004-05-06 2010-11-30 Nmt Medical, Inc. Double coil occluder
CA2563298A1 (en) 2004-05-07 2005-11-24 Nmt Medical, Inc. Catching mechanisms for tubular septal occluder
US9638770B2 (en) 2004-05-21 2017-05-02 Devicor Medical Products, Inc. MRI biopsy apparatus incorporating an imageable penetrating portion
US7708751B2 (en) * 2004-05-21 2010-05-04 Ethicon Endo-Surgery, Inc. MRI biopsy device
US8075568B2 (en) 2004-06-11 2011-12-13 Selis James E Biopsy devices and methods
EP1768618B1 (en) * 2004-07-09 2011-04-20 GI Dynamics, Inc. Devices for placing a gastrointestinal sleeve
US20060079923A1 (en) * 2004-08-09 2006-04-13 Manik Chhabra Aneurysm treatment using semi-compliant balloon
EP1799145B1 (en) * 2004-09-17 2016-12-21 GI Dynamics, Inc. Gastrointestinal anchor
CA2581677C (en) * 2004-09-24 2014-07-29 Nmt Medical, Inc. Occluder device double securement system for delivery/recovery of such occluder device
US8280486B2 (en) * 2004-10-13 2012-10-02 Suros Surgical Systems, Inc. Site marker visable under multiple modalities
US8442623B2 (en) * 2004-10-13 2013-05-14 Suros Surgical Systems, Inc. Site marker visible under multiple modalities
US20060079805A1 (en) * 2004-10-13 2006-04-13 Miller Michael E Site marker visable under multiple modalities
US8060183B2 (en) 2004-10-13 2011-11-15 Suros Surgical Systems, Inc. Site marker visible under multiple modalities
US8433391B2 (en) * 2004-10-13 2013-04-30 Suros Surgical Systems, Inc. Site marker
US20060094957A1 (en) * 2004-11-01 2006-05-04 Mueller Richard L Jr Marker and cut down guide assembly for human mammary duct procedures and method
US8409111B2 (en) 2004-11-22 2013-04-02 Bard Peripheral Vascular, Inc. Removable localizing wire
US7766973B2 (en) * 2005-01-19 2010-08-03 Gi Dynamics, Inc. Eversion resistant sleeves
US7771382B2 (en) * 2005-01-19 2010-08-10 Gi Dynamics, Inc. Resistive anti-obesity devices
US7785302B2 (en) 2005-03-04 2010-08-31 C. R. Bard, Inc. Access port identification systems and methods
US8029482B2 (en) 2005-03-04 2011-10-04 C. R. Bard, Inc. Systems and methods for radiographically identifying an access port
US7947022B2 (en) 2005-03-04 2011-05-24 C. R. Bard, Inc. Access port identification systems and methods
US9474888B2 (en) 2005-03-04 2016-10-25 C. R. Bard, Inc. Implantable access port including a sandwiched radiopaque insert
CN102271737B (en) 2008-10-31 2016-02-17 C·R·巴德股份有限公司 For providing subcutaneous access to a patient access port
US20060212042A1 (en) * 2005-03-17 2006-09-21 Lamport Ronald B Removal and repositioning device
US8277480B2 (en) 2005-03-18 2012-10-02 W.L. Gore & Associates, Inc. Catch member for PFO occluder
DE102005012574A1 (en) 2005-03-18 2006-09-21 Bkh - Technotransfer Gmbh Marker for animal and human tissues, especially soft tissue
US20060241411A1 (en) 2005-04-20 2006-10-26 Inrad, Inc. Marking device with retracable cannula
US7452364B2 (en) * 2005-04-22 2008-11-18 Helmut Schreiber Surgical marker/connector
US7931662B2 (en) * 2005-04-22 2011-04-26 Helmut Schreiber Surgical marker/connector and method of installation
US8147455B2 (en) 2005-04-27 2012-04-03 C. R. Bard, Inc. Infusion apparatuses and methods of use
EP2324880B1 (en) 2005-04-27 2014-12-24 C.R. Bard, Inc. Infusion apparatuses provided with septum
DE102005022901B4 (en) * 2005-05-18 2014-10-30 Siemens Aktiengesellschaft Method and apparatus for determining orientation of an instrument is located in an object
US7976488B2 (en) 2005-06-08 2011-07-12 Gi Dynamics, Inc. Gastrointestinal anchor compliance
US20070010844A1 (en) * 2005-07-08 2007-01-11 Gorman Gong Radiopaque expandable body and methods
US7704225B2 (en) 2005-07-29 2010-04-27 L-Vad Technology, Inc. Percutaneous access device system facilitating cell growth thereon
CA2627285A1 (en) * 2005-10-24 2007-10-25 Nmt Medical, Inc. Radiopaque bioabsorbable occluder
EP1962695A1 (en) 2005-12-22 2008-09-03 NMT Medical, Inc. Catch members for occluder devices
US20080230001A1 (en) * 2006-02-23 2008-09-25 Meadwestvaco Corporation Method for treating a substrate
CA2647505C (en) * 2006-03-31 2014-07-29 Nmt Medical, Inc. Deformable flap catch mechanism for occluder device
US8551135B2 (en) * 2006-03-31 2013-10-08 W.L. Gore & Associates, Inc. Screw catch mechanism for PFO occluder and method of use
US8870913B2 (en) 2006-03-31 2014-10-28 W.L. Gore & Associates, Inc. Catch system with locking cap for patent foramen ovale (PFO) occluder
US7819836B2 (en) * 2006-06-23 2010-10-26 Gi Dynamics, Inc. Resistive anti-obesity devices
US20110224538A1 (en) * 2006-07-13 2011-09-15 Luis Linares Echo-Opaque Catheter and method of use
US20080039819A1 (en) * 2006-08-04 2008-02-14 Senorx, Inc. Marker formed of starch or other suitable polysaccharide
US20080294039A1 (en) * 2006-08-04 2008-11-27 Senorx, Inc. Assembly with hemostatic and radiographically detectable pellets
US20080082083A1 (en) * 2006-09-28 2008-04-03 Forde Sean T Perforated expandable implant recovery sheath
US9265912B2 (en) 2006-11-08 2016-02-23 C. R. Bard, Inc. Indicia informative of characteristics of insertable medical devices
US9642986B2 (en) 2006-11-08 2017-05-09 C. R. Bard, Inc. Resource information key for an insertable medical device
US20080177179A1 (en) * 2006-12-19 2008-07-24 Cytyc Corporation Target Tissue Locator for Image Guided Radiotherapy
EP1959391A1 (en) * 2007-02-13 2008-08-20 BrainLAB AG Determination of the three dimensional contour path of an anatomical structure
US8801647B2 (en) * 2007-02-22 2014-08-12 Gi Dynamics, Inc. Use of a gastrointestinal sleeve to treat bariatric surgery fistulas and leaks
WO2008124603A1 (en) * 2007-04-05 2008-10-16 Nmt Medical, Inc. Septal closure device with centering mechanism
WO2008131167A1 (en) 2007-04-18 2008-10-30 Nmt Medical, Inc. Flexible catheter system
WO2008137757A1 (en) * 2007-05-04 2008-11-13 Barrx Medical, Inc. Method and apparatus for gastrointestinal tract ablation for treatment of obesity
ES2651269T3 (en) 2007-06-20 2018-01-25 Medical Components, Inc. molded venous reservoir with indications and / or radiopaque
US8251992B2 (en) 2007-07-06 2012-08-28 Tyco Healthcare Group Lp Method and apparatus for gastrointestinal tract ablation to achieve loss of persistent and/or recurrent excess body weight following a weight-loss operation
US8439908B2 (en) * 2007-07-06 2013-05-14 Covidien Lp Ablation in the gastrointestinal tract to achieve hemostasis and eradicate lesions with a propensity for bleeding
US20090024225A1 (en) * 2007-07-16 2009-01-22 Stubbs James B Implant for Targeting Therapeutic Procedure
WO2009012395A1 (en) 2007-07-19 2009-01-22 Innovative Medical Devices, Llc Venous access port assembly with x-ray discernable indicia
EP3311877A1 (en) 2007-07-19 2018-04-25 Medical Components, Inc. Venous access port assembly with x-ray discernable indicia
US9579496B2 (en) 2007-11-07 2017-02-28 C. R. Bard, Inc. Radiopaque and septum-based indicators for a multi-lumen implantable port
US8298211B2 (en) * 2007-11-21 2012-10-30 Suros Surgical Systems, Inc. Push button pull back device
US9592100B2 (en) * 2007-12-31 2017-03-14 St. Jude Medical, Atrial Fibrillation Division, Inc. Method and apparatus for encoding catheters with markers for identifying with imaging systems
US8202316B2 (en) * 2008-01-29 2012-06-19 Ledergerber Walter J Modulating buttress saline mammary prosthesis
US8068895B2 (en) * 2008-02-25 2011-11-29 Devicor Medical Products, Inc. Biopsy site marker deployment instrument
US8079964B2 (en) * 2008-02-25 2011-12-20 Devicor Medical Products, Inc. Method and apparatus for inserting biopsy site marker in marker body
US20130165967A1 (en) 2008-03-07 2013-06-27 W.L. Gore & Associates, Inc. Heart occlusion devices
JP5015087B2 (en) * 2008-08-04 2012-08-29 オリンパスメディカルシステムズ株式会社 Through an endoscope medical tool
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US8932271B2 (en) 2008-11-13 2015-01-13 C. R. Bard, Inc. Implantable medical devices including septum-based indicators
US20110237976A1 (en) * 2008-12-03 2011-09-29 The Regents Of The University Of Michigan Biopsy device having hemostatic control
US8241298B2 (en) * 2009-03-27 2012-08-14 Depuy Mitek, Inc. Methods and devices for delivering and affixing tissue scaffolds
US9014787B2 (en) * 2009-06-01 2015-04-21 Focal Therapeutics, Inc. Bioabsorbable target for diagnostic or therapeutic procedure
US8715244B2 (en) 2009-07-07 2014-05-06 C. R. Bard, Inc. Extensible internal bolster for a medical device
US20110028831A1 (en) * 2009-07-30 2011-02-03 Kent James P Permanently visible implantable fiduciary tissue marker
US8721621B2 (en) * 2009-09-10 2014-05-13 Taris Biomedical, Inc. Systems and methods for deploying devices to genitourinary sites
CN102612343B (en) 2009-11-17 2015-11-25 C·R·巴德股份有限公司 Inlet port means comprises an anchor identifier and the overmolded portion
US20110133730A1 (en) * 2009-12-04 2011-06-09 Simon Richard Hattersley Magnetic Probe Apparatus
US9427186B2 (en) * 2009-12-04 2016-08-30 Endomagnetics Ltd. Magnetic probe apparatus
FR2957777B1 (en) * 2010-03-23 2012-05-25 Nova Therma A device for the administration of calories in a tissue, vessel or human or animal cavity
US9561094B2 (en) 2010-07-23 2017-02-07 Nfinium Vascular Technologies, Llc Devices and methods for treating venous diseases
WO2012071224A1 (en) * 2010-11-24 2012-05-31 Cook Medical Technologies Llc Dome-shaped vascular filter
EP2655818B1 (en) 2010-12-23 2017-01-18 Caterpillar INC. Method and apparatus for measuring ash deposit levels in a particulate filter
USD682416S1 (en) 2010-12-30 2013-05-14 C. R. Bard, Inc. Implantable access port
USD676955S1 (en) 2010-12-30 2013-02-26 C. R. Bard, Inc. Implantable access port
US8980982B2 (en) 2011-03-25 2015-03-17 Illinois Tool Works, Inc. Electromagnetic spectrally detectable plastic packaging components
US9770232B2 (en) 2011-08-12 2017-09-26 W. L. Gore & Associates, Inc. Heart occlusion devices
US9943706B2 (en) 2012-01-12 2018-04-17 Surgical Radiation Products, Llc Targeting implant for external beam radiation
US9320517B2 (en) 2012-01-12 2016-04-26 Surgical Radiation Products, Llc Targeting implant for external beam radiation
EP2806907A1 (en) * 2012-01-24 2014-12-03 Lifecell Corporation Elongated tissue matrices
US20130289389A1 (en) * 2012-04-26 2013-10-31 Focal Therapeutics Surgical implant for marking soft tissue
US20140066774A1 (en) * 2012-08-31 2014-03-06 Elwha LLC., a limited liability company of the State of Delaware Biocompatible and ultrasound-differentiable micro-objects suitable for implantation in a vertebrate subject
ES2409691B1 (en) * 2012-11-16 2013-11-21 Federico MAYO MARTIN breast implant
WO2014081940A1 (en) * 2012-11-21 2014-05-30 Trustees Of Boston University Tissue markers and uses thereof
CN105283202A (en) 2013-03-11 2016-01-27 安都磁学有限公司 Hypoosmotic solutions for lymph node detection
US9234877B2 (en) 2013-03-13 2016-01-12 Endomagnetics Ltd. Magnetic detector
US9239314B2 (en) 2013-03-13 2016-01-19 Endomagnetics Ltd. Magnetic detector
US9119650B2 (en) 2013-03-15 2015-09-01 Covidien Lp Microwave energy-delivery device and system
US9161814B2 (en) * 2013-03-15 2015-10-20 Covidien Lp Microwave energy-delivery device and system
US9301723B2 (en) 2013-03-15 2016-04-05 Covidien Lp Microwave energy-delivery device and system
US9861449B2 (en) 2014-04-01 2018-01-09 University Of Utah Research Foundation Radiopaque marking implement
US9486309B2 (en) * 2014-04-25 2016-11-08 Allergan, Inc. Lighter weight implant
US9636210B2 (en) 2014-05-19 2017-05-02 Mentor Worldwide Llc Injection zone markers for biomedical implants
US9808230B2 (en) 2014-06-06 2017-11-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
WO2016014990A8 (en) 2014-07-25 2016-03-03 Focal Therapeutics, Inc. Implantable devices and techniques for oncoplastic surgery
CN104856759B (en) * 2015-03-26 2017-11-28 张海 A multi-mode breast development target and target-specific release means
US20160287792A1 (en) * 2015-04-02 2016-10-06 XEND Medical, LLC Plugged hypodermic needle system
WO2017083412A1 (en) 2015-11-11 2017-05-18 Devicor Medical Products, Inc. Marker delivery device and method of deploying a marker

Citations (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6181960B2 (en) *
US2740405A (en) * 1948-08-04 1956-04-03 Howard C Riordan Surgical sponge with radioactive tracer
US2972350A (en) * 1957-12-30 1961-02-21 Johnson & Johnson Surgical sponge
US4087791A (en) * 1974-09-09 1978-05-02 Minnesota Mining And Manufacturing Company Electromagnetically responsive device and system for detecting the same
US4197846A (en) * 1974-10-09 1980-04-15 Louis Bucalo Method for structure for situating in a living body agents for treating the body
US4202349A (en) * 1978-04-24 1980-05-13 Jones James W Radiopaque vessel markers
US4320201A (en) * 1979-10-27 1982-03-16 Firma Carl Freudenberg Method for making collagen sponge for medical and cosmetic uses
US4636208A (en) * 1984-10-05 1987-01-13 Ewald Rath Surgical sponge
US4639253A (en) * 1984-04-30 1987-01-27 Johnson & Johnson Products, Inc. Nonwoven surgical sponge with X-ray detectable element
US4645499A (en) * 1983-08-22 1987-02-24 The Kendall Company Surgical sponge
US4718897A (en) * 1985-09-18 1988-01-12 Chicopee Nonwoven surgical sponge with x-ray detectable element
US4735796A (en) * 1983-12-08 1988-04-05 Gordon Robert T Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease
US4735210A (en) * 1985-07-05 1988-04-05 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US4744364A (en) * 1987-02-17 1988-05-17 Intravascular Surgical Instruments, Inc. Device for sealing percutaneous puncture in a vessel
US4795463A (en) * 1984-10-03 1989-01-03 Baylor College Of Medicine Labeled breast prosthesis and methods for detecting and predicting rupture of the prosthesis
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
US4812120A (en) * 1987-11-02 1989-03-14 Flanagan Dennis F Implantable percutaneous device
US4832686A (en) * 1986-06-24 1989-05-23 Anderson Mark E Method for administering interleukin-2
US4909250A (en) * 1988-11-14 1990-03-20 Smith Joseph R Implant system for animal identification
US4917694A (en) * 1982-05-19 1990-04-17 The Kendall Company Surgical sponge
US5002548A (en) * 1986-10-06 1991-03-26 Bio Medic Data Systems, Inc. Animal marker implanting system
US5018530A (en) * 1989-06-15 1991-05-28 Research Corporation Technologies, Inc. Helical-tipped lesion localization needle device and method of using the same
US5085629A (en) * 1988-10-06 1992-02-04 Medical Engineering Corporation Biodegradable stent
US5101827A (en) * 1985-07-05 1992-04-07 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US5108421A (en) * 1990-10-01 1992-04-28 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5111828A (en) * 1990-09-18 1992-05-12 Peb Biopsy Corporation Device for percutaneous excisional breast biopsy
US5112325A (en) * 1989-02-17 1992-05-12 Deroyal Industries, Inc. Surgical sponge with plurality of radiopaque monofilaments
US5114703A (en) * 1989-05-30 1992-05-19 Alliance Pharmaceutical Corp. Percutaneous lymphography using particulate fluorocarbon emulsions
US5183463A (en) * 1989-02-03 1993-02-02 Elie Debbas Apparatus for locating a breast mass
US5192300A (en) * 1990-10-01 1993-03-09 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5195988A (en) * 1988-05-26 1993-03-23 Haaga John R Medical needle with removable sheath
US5195540A (en) * 1991-08-12 1993-03-23 Samuel Shiber Lesion marking process
US5197484A (en) * 1990-09-18 1993-03-30 Peb Biopsy Corporation Method and device for precutaneous excisional breast biopsy
US5201314A (en) * 1989-03-09 1993-04-13 Vance Products Incorporated Echogenic devices, material and method
US5204382A (en) * 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
US5207705A (en) * 1988-12-08 1993-05-04 Brigham And Women's Hospital Prosthesis of foam polyurethane and collagen and uses thereof
US5281197A (en) * 1992-07-27 1994-01-25 Symbiosis Corporation Endoscopic hemostatic agent delivery system
US5300120A (en) * 1992-08-24 1994-04-05 Lipomatrix Incorporated Implant with electrical transponder marker
US5301682A (en) * 1989-02-03 1994-04-12 Elie Debbas Method for locating a breast mass
US5380646A (en) * 1992-10-19 1995-01-10 Temple University Of The Commonwealth System Of Higher Education Thrombus detection using radiolabelled disintegrins
US5382251A (en) * 1989-01-31 1995-01-17 Biomet, Inc. Plug pulling method
US5388588A (en) * 1993-05-04 1995-02-14 Nabai; Hossein Biopsy wound closure device and method
US5394886A (en) * 1993-09-20 1995-03-07 Nabai; Hossein Skin biopsy plug and method
US5403306A (en) * 1993-06-22 1995-04-04 Vanderbilt University Laser surgery method
US5405402A (en) * 1993-04-14 1995-04-11 Intermedics Orthopedics, Inc. Implantable prosthesis with radiographic marker
US5409004A (en) * 1993-06-11 1995-04-25 Cook Incorporated Localization device with radiopaque markings
US5482040A (en) * 1994-04-14 1996-01-09 The Ohio State University Research Foundation Biostaging of adenocarcinomas utilizing radiolabeled tumor-associated glycoprotein antibodies
US5487392A (en) * 1993-11-15 1996-01-30 Haaga; John R. Biopxy system with hemostatic insert
US5507813A (en) * 1993-12-09 1996-04-16 Osteotech, Inc. Shaped materials derived from elongate bone particles
US5511566A (en) * 1994-06-02 1996-04-30 Hauni Maschinenbau Ag Distributor for particles of tobacco and the like
US5514379A (en) * 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US5595177A (en) * 1994-06-03 1997-01-21 Harbor-Ucla Research And Education Institute, Inc. Scintigraphy guided stereotaxic localizations apparatus for breast carcinomas
US5626611A (en) * 1994-02-10 1997-05-06 United States Surgical Corporation Composite bioabsorbable materials and surgical articles made therefrom
US5628744A (en) * 1993-12-21 1997-05-13 Laserscope Treatment beam handpiece
US5707393A (en) * 1991-11-08 1998-01-13 Kensey Nash Corporation Hemostatic puncture closure system and method of use
US5709676A (en) * 1990-02-14 1998-01-20 Alt; Eckhard Synergistic treatment of stenosed blood vessels using shock waves and dissolving medication
US5714551A (en) * 1995-10-02 1998-02-03 Ethicon, Inc. High strength, melt processable, lactide-rich, poly (lactide-co-p-dioxanone) copolymers
US5716407A (en) * 1992-08-24 1998-02-10 Lipomatrix, Incorporated Method of rendering identifiable a living tissue implant using an electrical transponder marker
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US5720772A (en) * 1992-10-20 1998-02-24 Esc Medical Systems Ltd. Method and apparatus for therapeutic electromagnetic treatment
US5723004A (en) * 1993-10-21 1998-03-03 Corvita Corporation Expandable supportive endoluminal grafts
US5725578A (en) * 1992-08-24 1998-03-10 Lipomatrix Incoporated Temporary implant with transponder and methods for locating and indentifying
US5725517A (en) * 1995-10-05 1998-03-10 Deroyal Industries, Inc. Absorbent woven article including radiopaque element woven therein and anchored at the ends thereof
US5732704A (en) * 1995-10-13 1998-03-31 Neoprobe Corporation Radiation based method locating and differentiating sentinel nodes
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US5855609A (en) * 1992-08-24 1999-01-05 Lipomatrix, Incorporated (Bvi) Medical information transponder implant and tracking system
US5856367A (en) * 1994-02-18 1999-01-05 Minnesota Mining And Manufacturing Company Biocompatible porous matrix of bioabsorbable material
US5857463A (en) * 1995-10-13 1999-01-12 Neoprobe Corporation Remotely controlled apparatus and system for tracking and locating a source of photoemissions
US5857998A (en) * 1994-06-30 1999-01-12 Boston Scientific Corporation Stent and therapeutic delivery system
US5868778A (en) * 1995-10-27 1999-02-09 Vascular Solutions, Inc. Vascular sealing apparatus and method
US5869080A (en) * 1995-05-30 1999-02-09 Johnson & Johnson Medical, Inc. Absorbable implant materials having controlled porosity
US5871501A (en) * 1994-01-18 1999-02-16 Datascope Investment Corp. Guide wire with releasable barb anchor
US5871535A (en) * 1990-02-28 1999-02-16 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5873904A (en) * 1995-06-07 1999-02-23 Cook Incorporated Silver implantable medical device
US5879357A (en) * 1995-10-20 1999-03-09 United States Surgical Corporation Apparatus for marking tissue location
US5895640A (en) * 1994-06-03 1999-04-20 Harbor-Ucla Research And Education Institute Nuclear medicine techniques for detecting carcinoma in the dense breast
US5895395A (en) * 1997-07-17 1999-04-20 Yeung; Teresa T. Partial to full thickness suture device & method for endoscopic surgeries
US5899865A (en) * 1988-12-21 1999-05-04 Non-Invasive Technology, Inc. Localization of abnormal breast tissue using time-resolved spectroscopy
US6030333A (en) * 1997-10-24 2000-02-29 Radiomed Corporation Implantable radiotherapy device
US6057122A (en) * 1996-05-03 2000-05-02 Abbott Laboratories Antiangiogenic peptides polynucleotides encoding same and methods for inhibiting angiogenesis
US6056700A (en) * 1998-10-13 2000-05-02 Emx, Inc. Biopsy marker assembly and method of use
US6066750A (en) * 1997-07-01 2000-05-23 Arco Chemical Technology, L.P. High efficiency epoxidation process
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US6068857A (en) * 1993-09-09 2000-05-30 Schering Aktiengesellchaft Microparticles containing active ingredients, agents containing these microparticles, their use for ultrasound-controlled release of active ingredients, as well as a process for their production
US6174330B1 (en) * 1997-08-01 2001-01-16 Schneider (Usa) Inc Bioabsorbable marker having radiopaque constituents
US6179860B1 (en) * 1998-08-19 2001-01-30 Artemis Medical, Inc. Target tissue localization device and method
US6181960B1 (en) * 1998-01-15 2001-01-30 University Of Virginia Patent Foundation Biopsy marker device
US6183497B1 (en) * 1998-05-01 2001-02-06 Sub-Q, Inc. Absorbable sponge with contrasting agent
US6197324B1 (en) * 1997-12-18 2001-03-06 C. R. Bard, Inc. System and methods for local delivery of an agent
US6200328B1 (en) * 1998-05-01 2001-03-13 Sub Q, Incorporated Device and method for facilitating hemostasis of a biopsy tract
US6214045B1 (en) * 1997-10-10 2001-04-10 John D. Corbitt, Jr. Bioabsorbable breast implant
US6228055B1 (en) * 1994-09-16 2001-05-08 Ethicon Endo-Surgery, Inc. Devices for marking and defining particular locations in body tissue
US6231834B1 (en) * 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6340367B1 (en) * 1997-08-01 2002-01-22 Boston Scientific Scimed, Inc. Radiopaque markers and methods of using the same
US6347241B2 (en) * 1999-02-02 2002-02-12 Senorx, Inc. Ultrasonic and x-ray detectable biopsy site marker and apparatus for applying it
US6356782B1 (en) * 1998-12-24 2002-03-12 Vivant Medical, Inc. Subcutaneous cavity marking device and method
US6371904B1 (en) * 1998-12-24 2002-04-16 Vivant Medical, Inc. Subcutaneous cavity marking device and method

Family Cites Families (165)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US557118A (en) 1896-03-31 Mucilage-bottle
US2609347A (en) 1948-05-27 1952-09-02 Wilson Christopher Lumley Method of making expanded polyvinyl alcohol-formaldehyde reaction product and product resulting therefrom
US2664366A (en) 1949-09-19 1953-12-29 Wilson Christopher Lumley Plasticized sponge material and method of making same
US2664367A (en) 1949-09-19 1953-12-29 Wilson Christopher Lumley Plasticized sponge material and method of making same
US2659935A (en) 1950-03-18 1953-11-24 Christopher L Wilson Method of making compressed sponges
US2653917A (en) 1950-06-15 1953-09-29 Christopher L Wilson Method of making an expanded material and the product resulting therefrom
DE935625C (en) 1952-10-18 1955-11-24 Leonore Bodendieck Exzisionsgeraet
US2846407A (en) 1954-01-13 1958-08-05 Wilson Christopher Lumley Method of making a detergent and solvent resistant sponge material
US3001522A (en) 1957-12-26 1961-09-26 Silverman Irving Biopsy device
US3194239A (en) 1963-01-16 1965-07-13 Cornelius J P Sullivan Suture provided with radiopaque free metal
US3592185A (en) 1967-04-18 1971-07-13 Yeda Res & Dev Ferromagnetic contrast media and method of use
US3823212A (en) 1968-11-27 1974-07-09 Freudenberg C Fa Process for the production of collagen fiber fabrics in the form of felt-like membranes or sponge-like layers
US3844272A (en) 1969-02-14 1974-10-29 A Banko Surgical instruments
US4127110A (en) 1976-05-24 1978-11-28 Huntington Institute Of Applied Medical Research Implantable pressure transducer
US4114601A (en) 1976-08-09 1978-09-19 Micro Tec Instrumentation, Inc. Medical and surgical implement detection system
US5962572A (en) * 1994-04-19 1999-10-05 Applied Elastomerics, Inc. Oriented gel and oriented gel articles
US5633286B1 (en) * 1977-03-17 2000-10-10 Applied Elastomerics Inc Gelatinous elastomer articles
US6148830A (en) * 1994-04-19 2000-11-21 Applied Elastomerics, Inc. Tear resistant, multiblock copolymer gels and articles
US6117176A (en) * 1993-11-15 2000-09-12 Applied Elastomerics, Inc. Elastic-crystal gel
US7093599B2 (en) * 1994-04-19 2006-08-22 Applied Elastomerics, Inc. Gels, composites, and health care articles
DE2843963C2 (en) 1978-10-09 1988-02-18 Merck Patent Gmbh, 6100 Darmstadt, De
US4230123A (en) 1978-10-31 1980-10-28 Hawkins Jr Irvin F Needle sheath complex and process for decompression and biopsy
FR2460657B1 (en) 1979-07-12 1984-01-20 Anvar
US4320321A (en) 1980-03-25 1982-03-16 Alexandrov Vitaly V Hollow-cathode gas-discharge tube
US4298998A (en) 1980-12-08 1981-11-10 Naficy Sadeque S Breast prosthesis with biologically absorbable outer container
US4628944A (en) 1982-02-08 1986-12-16 Cordis Corporation Cardiac pacing lead with biodegradable fixation structure
DE3379413D1 (en) * 1982-08-26 1989-04-20 Shoyo Engineering Company Limi Shaft coupling
US4531933A (en) 1982-12-07 1985-07-30 C. R. Bard, Inc. Helical ureteral stent
US4541438A (en) 1983-06-02 1985-09-17 The Johns Hopkins University Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin tumor-specific markers excited by long wavelength light
US5041103A (en) 1983-08-22 1991-08-20 The Kendall Company Surgical sponge and method of making
US4704109A (en) 1983-08-22 1987-11-03 The Kendall Company Surgical sponge
EP0146699A1 (en) 1983-12-22 1985-07-03 Gebrüder Sulzer Aktiengesellschaft Implanted marker
JPS60171475A (en) 1984-02-15 1985-09-04 Thomas A Milheiser Discriminating system
CA1295796C (en) 1984-03-27 1992-02-18 Conrad Whyne Biodegradable matrix and methods for producing same
US4626251A (en) 1985-02-22 1986-12-02 Albert Shen Surgical sponge
US4863470A (en) 1985-03-19 1989-09-05 Medical Engineering Corporation Identification marker for a breast prosthesis
US4787391A (en) 1985-06-17 1988-11-29 Elefteriades John A Anastomotic marking device and related method
DE3522626C2 (en) 1985-06-25 1988-04-21 Merz + Co Gmbh & Co, 6000 Frankfurt, De
US5776093A (en) 1985-07-05 1998-07-07 Immunomedics, Inc. Method for imaging and treating organs and tissues
US4693237A (en) 1986-01-21 1987-09-15 Hoffman Richard B Radiopaque coded ring markers for use in identifying surgical grafts
US4682606A (en) 1986-02-03 1987-07-28 Decaprio Vincent H Localizing biopsy apparatus
DE3789320T2 (en) 1986-07-30 1994-06-09 Sumitomo Pharma An administration tool for inserting solid medicaments.
US5045080A (en) 1986-12-22 1991-09-03 Johnson & Johnson Medical, Inc. Surgical fabric with printed X-ray marker
US4852568A (en) 1987-02-17 1989-08-01 Kensey Nash Corporation Method and apparatus for sealing an opening in tissue of a living being
US4817600A (en) 1987-05-22 1989-04-04 Medi-Tech, Inc. Implantable filter
DE3889635D1 (en) 1987-11-19 1994-06-23 Bard Inc C R Sampling drive unit.
US5120802A (en) 1987-12-17 1992-06-09 Allied-Signal Inc. Polycarbonate-based block copolymers and devices
US4985019A (en) * 1988-03-11 1991-01-15 Michelson Gary K X-ray marker
US5117146A (en) * 1988-04-29 1992-05-26 The United States Of America As Represented By The United States Department Of Energy Acoustic wave device using plate modes with surface-parallel displacement
US4832055A (en) 1988-07-08 1989-05-23 Palestrant Aubrey M Mechanically locking blood clot filter
US5444113A (en) 1988-08-08 1995-08-22 Ecopol, Llc End use applications of biodegradable polymers
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5258028A (en) * 1988-12-12 1993-11-02 Ersek Robert A Textured micro implants
US4966583A (en) 1989-02-03 1990-10-30 Elie Debbas Apparatus for locating a breast mass
GB2230191B (en) 1989-04-15 1992-04-22 Robert Graham Urie Lesion location device
US5100429A (en) * 1989-04-28 1992-03-31 C. R. Bard, Inc. Endovascular stent and delivery system
US5197482A (en) * 1989-06-15 1993-03-30 Research Corporation Technologies, Inc. Helical-tipped lesion localization needle device and method of using the same
WO1991006286A1 (en) 1989-11-06 1991-05-16 Enzytech, Inc. Method for producing protein microspheres
US5374246A (en) 1989-11-07 1994-12-20 Ray; Joel W. Method and device for delivering a hemostatic agent to an operating status
US5057095A (en) 1989-11-16 1991-10-15 Fabian Carl E Surgical implement detector utilizing a resonant marker
US5329944A (en) 1989-11-16 1994-07-19 Fabian Carl E Surgical implement detector utilizing an acoustic marker
US4986682A (en) 1989-12-19 1991-01-22 Lu Shuenn Chin Retractable finger pen
US5252962A (en) * 1990-08-03 1993-10-12 Bio Medic Data Systems System monitoring programmable implantable transponder
US6099457A (en) * 1990-08-13 2000-08-08 Endotech, Inc. Endocurietherapy
US5353804A (en) 1990-09-18 1994-10-11 Peb Biopsy Corporation Method and device for percutaneous exisional breast biopsy
US5221269A (en) 1990-10-15 1993-06-22 Cook Incorporated Guide for localizing a nonpalpable breast lesion
US5148813A (en) 1990-11-20 1992-09-22 Bucalo Brian D Biopsy instrument with tissue specimen retaining and retrieval device
US5127916A (en) 1991-01-22 1992-07-07 Medical Device Technologies, Inc. Localization needle assembly
US5235326A (en) * 1991-08-15 1993-08-10 Avid Corporation Multi-mode identification system
CA2078530A1 (en) 1991-09-23 1993-03-24 Jay Erlebacher Percutaneous arterial puncture seal device and insertion tool therefore
US5376376A (en) 1992-01-13 1994-12-27 Li; Shu-Tung Resorbable vascular wound dressings
EP0633798B1 (en) 1992-03-31 2003-05-07 Boston Scientific Corporation Vascular filter
FR2689400B1 (en) 1992-04-03 1995-06-23 Inoteb A bone replacement material containing dispersed calcium carbonate particles in a bioabsorbable polymer matrix.
US5326350A (en) 1992-05-11 1994-07-05 Li Shu Tung Soft tissue closure systems
US5518730A (en) * 1992-06-03 1996-05-21 Fuisz Technologies Ltd. Biodegradable controlled release flash flow melt-spun delivery system
US5437279A (en) 1992-07-02 1995-08-01 Board Of Regents, The University Of Texas System Method of predicting carcinomic metastases
WO1994002068A1 (en) 1992-07-21 1994-02-03 The General Hospital Corporation System of drug delivery to the lymphatic tissues
US5460182A (en) 1992-09-14 1995-10-24 Sextant Medical Corporation Tissue penetrating apparatus and methods
WO1994006460A1 (en) 1992-09-21 1994-03-31 Vitaphore Corporation Embolization plugs for blood vessels
US5664582A (en) 1992-11-17 1997-09-09 Szymaitis; Dennis W. Method for detecting, distinguishing and counting objects
US5456718A (en) 1992-11-17 1995-10-10 Szymaitis; Dennis W. Apparatus for detecting surgical objects within the human body
US5334216A (en) 1992-12-10 1994-08-02 Howmedica Inc. Hemostatic plug
US5817017A (en) * 1994-04-12 1998-10-06 Pharmacyclics, Inc. Medical devices and materials having enhanced magnetic images visibility
DE69412474T2 (en) * 1993-04-28 1998-12-17 Focal Inc Device, product, and use on the intraluminal photothermographic shaping
ES2186688T3 (en) 1993-07-12 2003-05-16 Univ California Kit for soft tissue augmentation.
US5676698A (en) 1993-09-07 1997-10-14 Datascope Investment Corp. Soft tissue implant
US5546957A (en) 1993-09-09 1996-08-20 Norbert Heske Biopsy needle
DE4330958A1 (en) 1993-09-09 1995-03-16 Schering Ag Novel microparticles containing active compound, media containing these, their use for the ultrasonically controlled release of active compounds and process for the production thereof
US5531716A (en) * 1993-09-29 1996-07-02 Hercules Incorporated Medical devices subject to triggered disintegration
FR2714284B1 (en) 1993-12-23 1996-03-08 Hubert Petitier Prosthesis for the closure ruptures the heart walls, including ventricular septal rupture.
DE4403789A1 (en) 1994-02-03 1995-08-10 Schering Ag Means for visually marking body tissue
CA2140053C (en) 1994-02-09 2000-04-04 Joel S. Rosenblatt Collagen-based injectable drug delivery system and its use
US5817033A (en) 1994-04-11 1998-10-06 Desantis; Stephen A. Needle core biopsy device
US5560373A (en) 1994-04-11 1996-10-01 De Santis; Stephen A. Needle core biopsy instrument with durable or disposable cannula assembly
DE69527141T2 (en) * 1994-04-29 2002-11-07 Scimed Life Systems Inc Stent with collagen
US5803913A (en) 1994-06-03 1998-09-08 Khalkhali; Iraj Nuclear medicine stereotaxic localization apparatus for breast carcinomas and method
US5665063A (en) * 1994-06-24 1997-09-09 Focal, Inc. Methods for application of intraluminal photopolymerized gels
US5451406A (en) 1994-07-14 1995-09-19 Advanced Uroscience, Inc. Tissue injectable composition and method of use
US5480432A (en) * 1994-07-27 1996-01-02 Helix Medical Corporation Extended dwell voice prosthesis
US5923001A (en) * 1994-08-05 1999-07-13 Surgical Resources, L.L.C. Automatic surgical sponge counter and blood loss determination system
US5626603A (en) * 1994-10-05 1997-05-06 Fogazzi Di Ventureli Andrea & C. S.N.C. Hydraulic stent inserter
US5827531A (en) 1994-12-02 1998-10-27 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Microcapsules and methods for making
FR2731343B1 (en) 1995-03-08 1997-08-22 De La Joliniere Jean H Bouquet A suspicious lesions Locating the breast and apparatus for its implementation
US5807276A (en) 1995-03-09 1998-09-15 Russin; Lincoln David Biopsy device and method
US5795308A (en) 1995-03-09 1998-08-18 Russin; Lincoln D. Apparatus for coaxial breast biopsy
US5702449A (en) * 1995-06-07 1997-12-30 Danek Medical, Inc. Reinforced porous spinal implants
US6092009A (en) 1995-07-31 2000-07-18 Alliedsignal Aircraft terrain information system
FR2737969B1 (en) * 1995-08-24 1998-01-30 Rieu Regis Intraluminal endoprosthesis in particular destiny has angioplasty
US5645566A (en) 1995-09-15 1997-07-08 Sub Q Inc. Apparatus and method for percutaneous sealing of blood vessel punctures
US6068325A (en) * 1995-09-21 2000-05-30 Hughes; Charles A. Golf club cover for golf carts
US5575781A (en) 1995-10-05 1996-11-19 Deroyal Industries, Inc. Absorbent article useful in medical applications
US5833603A (en) * 1996-03-13 1998-11-10 Lipomatrix, Inc. Implantable biosensing transponder
DE19611769A1 (en) * 1996-03-14 1997-09-18 Schering Ag Microparticles, methods for their preparation, and their use in ultrasound diagnostics
JP3418497B2 (en) * 1996-04-16 2003-06-23 松下電器産業株式会社 Parts recognition method
US6006750A (en) 1996-04-30 1999-12-28 Medtronic, Inc. Position sensing system and method for using the same
US5670161A (en) 1996-05-28 1997-09-23 Healy; Kevin E. Biodegradable stent
US5853366A (en) 1996-07-08 1998-12-29 Kelsey, Inc. Marker element for interstitial treatment and localizing device and method using same
US5823198A (en) 1996-07-31 1998-10-20 Micro Therapeutics, Inc. Method and apparatus for intravasculer embolization
US5913857A (en) 1996-08-29 1999-06-22 Ethicon End0-Surgery, Inc. Methods and devices for collection of soft tissue
US5810806A (en) 1996-08-29 1998-09-22 Ethicon Endo-Surgery Methods and devices for collection of soft tissue
US6154560A (en) 1996-08-30 2000-11-28 The Cleveland Clinic Foundation System and method for staging regional lymph nodes using quantitative analysis of endoscopic ultrasound images
US5676146B1 (en) 1996-09-13 2000-04-18 Osteotech Inc Surgical implant containing a resorbable radiopaque marker and method of locating such within a body
DE19638585A1 (en) 1996-09-20 1998-03-26 Biotronik Mess & Therapieg Device for Rejektionsdiagnostik after organ transplantation
US6106473A (en) * 1996-11-06 2000-08-22 Sts Biopolymers, Inc. Echogenic coatings
WO1998030252A1 (en) 1997-01-09 1998-07-16 Cohesion Technologies, Inc. Methods and apparatuses for making swellable uniformly shaped devices from polymeric materials
DE19711932A1 (en) 1997-03-21 1998-09-24 Anne Katrin Dr Werenskiold An in vitro method for predicting the clinical course of patients with breast cancer and / or for diagnosing of breast cancer
US5865568A (en) 1997-03-27 1999-02-02 Relin; Arkadi Method of and device for suction transporting
WO1998047430A1 (en) 1997-04-23 1998-10-29 Vascular Science Inc. Medical plug
DE19721947C2 (en) 1997-05-21 1999-04-22 Diagnostikforschung Inst include use of pharmaceutical preparations, the particles, vesicles, or polymers as well as nonsteroidal anti-inflammatory and / or platelet aggregation inhibitors showing the vessels, lymph nodes and bone marrow
GB9710604D0 (en) 1997-05-22 1997-07-16 Nycomed Imaging As Contrast media
WO1999011196A1 (en) 1997-09-04 1999-03-11 Point Biomedical Corporation Injectable tissue reconstruction material
EP1017336B1 (en) * 1997-09-24 2007-08-15 Med Institute, Inc. Radially expandable stent
US6638308B2 (en) * 1997-10-10 2003-10-28 John D. Corbitt, Jr. Bioabsorbable breast implant
US6309420B1 (en) * 1997-10-14 2001-10-30 Parallax Medical, Inc. Enhanced visibility materials for implantation in hard tissue
US5961458A (en) 1997-11-18 1999-10-05 Carewise Medical Products Corporation Minimally invasive surgical probe for tissue identification and retrieval and method of use
US6241691B1 (en) * 1997-12-05 2001-06-05 Micrus Corporation Coated superelastic stent
US6168570B1 (en) * 1997-12-05 2001-01-02 Micrus Corporation Micro-strand cable with enhanced radiopacity
US6159165A (en) 1997-12-05 2000-12-12 Micrus Corporation Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand
US6007495A (en) 1998-01-22 1999-12-28 United States Surgical Corporation Biopsy apparatus and method
US6083167A (en) * 1998-02-10 2000-07-04 Emory University Systems and methods for providing radiation therapy and catheter guides
US6026818A (en) * 1998-03-02 2000-02-22 Blair Port Ltd. Tag and detection device
WO1999046284A3 (en) 1998-03-13 2000-04-06 Burnham Inst Molecules that home to various selected organs or tissues
US6395253B2 (en) * 1998-04-23 2002-05-28 The Regents Of The University Of Michigan Microspheres containing condensed polyanionic bioactive agents and methods for their production
US6162192A (en) 1998-05-01 2000-12-19 Sub Q, Inc. System and method for facilitating hemostasis of blood vessel punctures with absorbable sponge
US6071301A (en) 1998-05-01 2000-06-06 Sub Q., Inc. Device and method for facilitating hemostasis of a biopsy tract
DE69935716T2 (en) * 1998-05-05 2007-08-16 Boston Scientific Ltd., St. Michael Stent with smooth end
US6363940B1 (en) * 1998-05-14 2002-04-02 Calypso Medical Technologies, Inc. System and method for bracketing and removing tissue
EP2130511A1 (en) * 2000-11-17 2009-12-09 Calypso Medical, Inc System for locating and defining a target location within a human body
US6270464B1 (en) 1998-06-22 2001-08-07 Artemis Medical, Inc. Biopsy localization method and device
US5941890A (en) 1998-06-26 1999-08-24 Ethicon Endo-Surgery, Inc. Implantable surgical marker
US6080099A (en) * 1998-08-12 2000-06-27 Syntheon, Llc Radioactive therapeutic seeds
US6304766B1 (en) 1998-08-26 2001-10-16 Sensors For Medicine And Science Optical-based sensing devices, especially for in-situ sensing in humans
ES2319472T3 (en) 1998-10-23 2009-05-07 United States Surgical Corporation Site marker device.
US6254548B1 (en) * 1998-11-25 2001-07-03 Ball Semiconductor, Inc. Internal thermometer
WO2000030534A1 (en) * 1998-11-25 2000-06-02 Ball Semiconductor, Inc. Spherically-shaped biomedical ic
EP1985320B1 (en) 1998-12-01 2017-06-21 Cook Biotech, Inc. A multi-formed collagenous biomaterial medical device
US6126675A (en) 1999-01-11 2000-10-03 Ethicon, Inc. Bioabsorbable device and method for sealing vascular punctures
US6232139B1 (en) * 1999-01-29 2001-05-15 Sandia Corporation Method of making suspended thin-film semiconductor piezoelectric devices
US6725083B1 (en) 1999-02-02 2004-04-20 Senorx, Inc. Tissue site markers for in VIVO imaging
US6161034A (en) * 1999-02-02 2000-12-12 Senorx, Inc. Methods and chemical preparations for time-limited marking of biopsy sites
WO2000045858A1 (en) 1999-02-08 2000-08-10 Collagenesis, Inc. Collagen-based delivery of radioactivity for use in brachytherapy
DE60034317D1 (en) 1999-02-25 2007-05-24 Ge Healthcare Ltd Medical instruments and devices with improved ultrasound visibility
US6766186B1 (en) * 1999-06-16 2004-07-20 C. R. Bard, Inc. Post biospy tissue marker and method of use
US6234177B1 (en) 1999-08-12 2001-05-22 Thomas Barsch Apparatus and method for deploying an expandable biopsy marker
US6811776B2 (en) * 2000-12-27 2004-11-02 The Regents Of The University Of Michigan Process for ex vivo formation of mammalian bone and uses thereof

Patent Citations (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6181960B2 (en) *
US2740405A (en) * 1948-08-04 1956-04-03 Howard C Riordan Surgical sponge with radioactive tracer
US2972350A (en) * 1957-12-30 1961-02-21 Johnson & Johnson Surgical sponge
US4087791A (en) * 1974-09-09 1978-05-02 Minnesota Mining And Manufacturing Company Electromagnetically responsive device and system for detecting the same
US4197846A (en) * 1974-10-09 1980-04-15 Louis Bucalo Method for structure for situating in a living body agents for treating the body
US4202349A (en) * 1978-04-24 1980-05-13 Jones James W Radiopaque vessel markers
US4320201A (en) * 1979-10-27 1982-03-16 Firma Carl Freudenberg Method for making collagen sponge for medical and cosmetic uses
US4917694A (en) * 1982-05-19 1990-04-17 The Kendall Company Surgical sponge
US4645499A (en) * 1983-08-22 1987-02-24 The Kendall Company Surgical sponge
US4735796A (en) * 1983-12-08 1988-04-05 Gordon Robert T Ferromagnetic, diamagnetic or paramagnetic particles useful in the diagnosis and treatment of disease
US4639253A (en) * 1984-04-30 1987-01-27 Johnson & Johnson Products, Inc. Nonwoven surgical sponge with X-ray detectable element
US4795463A (en) * 1984-10-03 1989-01-03 Baylor College Of Medicine Labeled breast prosthesis and methods for detecting and predicting rupture of the prosthesis
US4636208A (en) * 1984-10-05 1987-01-13 Ewald Rath Surgical sponge
US4735210A (en) * 1985-07-05 1988-04-05 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US5101827A (en) * 1985-07-05 1992-04-07 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US4718897A (en) * 1985-09-18 1988-01-12 Chicopee Nonwoven surgical sponge with x-ray detectable element
US4832686A (en) * 1986-06-24 1989-05-23 Anderson Mark E Method for administering interleukin-2
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
US5002548A (en) * 1986-10-06 1991-03-26 Bio Medic Data Systems, Inc. Animal marker implanting system
US4744364A (en) * 1987-02-17 1988-05-17 Intravascular Surgical Instruments, Inc. Device for sealing percutaneous puncture in a vessel
US4812120A (en) * 1987-11-02 1989-03-14 Flanagan Dennis F Implantable percutaneous device
US5195988A (en) * 1988-05-26 1993-03-23 Haaga John R Medical needle with removable sheath
US5085629A (en) * 1988-10-06 1992-02-04 Medical Engineering Corporation Biodegradable stent
US4909250A (en) * 1988-11-14 1990-03-20 Smith Joseph R Implant system for animal identification
US5207705A (en) * 1988-12-08 1993-05-04 Brigham And Women's Hospital Prosthesis of foam polyurethane and collagen and uses thereof
US5899865A (en) * 1988-12-21 1999-05-04 Non-Invasive Technology, Inc. Localization of abnormal breast tissue using time-resolved spectroscopy
US5382251A (en) * 1989-01-31 1995-01-17 Biomet, Inc. Plug pulling method
US5301682A (en) * 1989-02-03 1994-04-12 Elie Debbas Method for locating a breast mass
US5183463A (en) * 1989-02-03 1993-02-02 Elie Debbas Apparatus for locating a breast mass
US5112325A (en) * 1989-02-17 1992-05-12 Deroyal Industries, Inc. Surgical sponge with plurality of radiopaque monofilaments
US5201314A (en) * 1989-03-09 1993-04-13 Vance Products Incorporated Echogenic devices, material and method
US5114703A (en) * 1989-05-30 1992-05-19 Alliance Pharmaceutical Corp. Percutaneous lymphography using particulate fluorocarbon emulsions
US5496536A (en) * 1989-05-30 1996-03-05 Wolf; Gerald Percutaneous lymphography
US5018530A (en) * 1989-06-15 1991-05-28 Research Corporation Technologies, Inc. Helical-tipped lesion localization needle device and method of using the same
US5709676A (en) * 1990-02-14 1998-01-20 Alt; Eckhard Synergistic treatment of stenosed blood vessels using shock waves and dissolving medication
US5871535A (en) * 1990-02-28 1999-02-16 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5197484A (en) * 1990-09-18 1993-03-30 Peb Biopsy Corporation Method and device for precutaneous excisional breast biopsy
US5111828A (en) * 1990-09-18 1992-05-12 Peb Biopsy Corporation Device for percutaneous excisional breast biopsy
US5275616A (en) * 1990-10-01 1994-01-04 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5108421A (en) * 1990-10-01 1992-04-28 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5192300A (en) * 1990-10-01 1993-03-09 Quinton Instrument Company Insertion assembly and method of inserting a vessel plug into the body of a patient
US5275616B1 (en) * 1990-10-01 1996-01-23 Quinton Instr Insertion assembly and method of inserting a vessel plug into the body of a patient
US5195540A (en) * 1991-08-12 1993-03-23 Samuel Shiber Lesion marking process
US5707393A (en) * 1991-11-08 1998-01-13 Kensey Nash Corporation Hemostatic puncture closure system and method of use
US5204382A (en) * 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
US5281197A (en) * 1992-07-27 1994-01-25 Symbiosis Corporation Endoscopic hemostatic agent delivery system
US5514379A (en) * 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US5855609A (en) * 1992-08-24 1999-01-05 Lipomatrix, Incorporated (Bvi) Medical information transponder implant and tracking system
US5725578A (en) * 1992-08-24 1998-03-10 Lipomatrix Incoporated Temporary implant with transponder and methods for locating and indentifying
US5716407A (en) * 1992-08-24 1998-02-10 Lipomatrix, Incorporated Method of rendering identifiable a living tissue implant using an electrical transponder marker
US5300120A (en) * 1992-08-24 1994-04-05 Lipomatrix Incorporated Implant with electrical transponder marker
US5380646A (en) * 1992-10-19 1995-01-10 Temple University Of The Commonwealth System Of Higher Education Thrombus detection using radiolabelled disintegrins
US5720772A (en) * 1992-10-20 1998-02-24 Esc Medical Systems Ltd. Method and apparatus for therapeutic electromagnetic treatment
US5405402A (en) * 1993-04-14 1995-04-11 Intermedics Orthopedics, Inc. Implantable prosthesis with radiographic marker
US5388588A (en) * 1993-05-04 1995-02-14 Nabai; Hossein Biopsy wound closure device and method
US5409004A (en) * 1993-06-11 1995-04-25 Cook Incorporated Localization device with radiopaque markings
US5403306A (en) * 1993-06-22 1995-04-04 Vanderbilt University Laser surgery method
US6068857A (en) * 1993-09-09 2000-05-30 Schering Aktiengesellchaft Microparticles containing active ingredients, agents containing these microparticles, their use for ultrasound-controlled release of active ingredients, as well as a process for their production
US5394886A (en) * 1993-09-20 1995-03-07 Nabai; Hossein Skin biopsy plug and method
US5723004A (en) * 1993-10-21 1998-03-03 Corvita Corporation Expandable supportive endoluminal grafts
US5487392A (en) * 1993-11-15 1996-01-30 Haaga; John R. Biopxy system with hemostatic insert
US5718237A (en) * 1993-11-15 1998-02-17 Haaga; John R. Biopsy needle
US5507813A (en) * 1993-12-09 1996-04-16 Osteotech, Inc. Shaped materials derived from elongate bone particles
US5628744A (en) * 1993-12-21 1997-05-13 Laserscope Treatment beam handpiece
US5871501A (en) * 1994-01-18 1999-02-16 Datascope Investment Corp. Guide wire with releasable barb anchor
US5626611A (en) * 1994-02-10 1997-05-06 United States Surgical Corporation Composite bioabsorbable materials and surgical articles made therefrom
US5856367A (en) * 1994-02-18 1999-01-05 Minnesota Mining And Manufacturing Company Biocompatible porous matrix of bioabsorbable material
US5482040A (en) * 1994-04-14 1996-01-09 The Ohio State University Research Foundation Biostaging of adenocarcinomas utilizing radiolabeled tumor-associated glycoprotein antibodies
US5511566A (en) * 1994-06-02 1996-04-30 Hauni Maschinenbau Ag Distributor for particles of tobacco and the like
US5595177A (en) * 1994-06-03 1997-01-21 Harbor-Ucla Research And Education Institute, Inc. Scintigraphy guided stereotaxic localizations apparatus for breast carcinomas
US5895640A (en) * 1994-06-03 1999-04-20 Harbor-Ucla Research And Education Institute Nuclear medicine techniques for detecting carcinoma in the dense breast
US5857998A (en) * 1994-06-30 1999-01-12 Boston Scientific Corporation Stent and therapeutic delivery system
US6228055B1 (en) * 1994-09-16 2001-05-08 Ethicon Endo-Surgery, Inc. Devices for marking and defining particular locations in body tissue
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
US5869080A (en) * 1995-05-30 1999-02-09 Johnson & Johnson Medical, Inc. Absorbable implant materials having controlled porosity
US5873904A (en) * 1995-06-07 1999-02-23 Cook Incorporated Silver implantable medical device
US6231834B1 (en) * 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US5714551A (en) * 1995-10-02 1998-02-03 Ethicon, Inc. High strength, melt processable, lactide-rich, poly (lactide-co-p-dioxanone) copolymers
US5725517A (en) * 1995-10-05 1998-03-10 Deroyal Industries, Inc. Absorbent woven article including radiopaque element woven therein and anchored at the ends thereof
US5857463A (en) * 1995-10-13 1999-01-12 Neoprobe Corporation Remotely controlled apparatus and system for tracking and locating a source of photoemissions
US5732704A (en) * 1995-10-13 1998-03-31 Neoprobe Corporation Radiation based method locating and differentiating sentinel nodes
US5879357A (en) * 1995-10-20 1999-03-09 United States Surgical Corporation Apparatus for marking tissue location
US5868778A (en) * 1995-10-27 1999-02-09 Vascular Solutions, Inc. Vascular sealing apparatus and method
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US6057122A (en) * 1996-05-03 2000-05-02 Abbott Laboratories Antiangiogenic peptides polynucleotides encoding same and methods for inhibiting angiogenesis
US6066325A (en) * 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US6066750A (en) * 1997-07-01 2000-05-23 Arco Chemical Technology, L.P. High efficiency epoxidation process
US5895395A (en) * 1997-07-17 1999-04-20 Yeung; Teresa T. Partial to full thickness suture device & method for endoscopic surgeries
US6340367B1 (en) * 1997-08-01 2002-01-22 Boston Scientific Scimed, Inc. Radiopaque markers and methods of using the same
US6174330B1 (en) * 1997-08-01 2001-01-16 Schneider (Usa) Inc Bioabsorbable marker having radiopaque constituents
US6214045B1 (en) * 1997-10-10 2001-04-10 John D. Corbitt, Jr. Bioabsorbable breast implant
US6030333A (en) * 1997-10-24 2000-02-29 Radiomed Corporation Implantable radiotherapy device
US6197324B1 (en) * 1997-12-18 2001-03-06 C. R. Bard, Inc. System and methods for local delivery of an agent
US6181960B1 (en) * 1998-01-15 2001-01-30 University Of Virginia Patent Foundation Biopsy marker device
US6183497B1 (en) * 1998-05-01 2001-02-06 Sub-Q, Inc. Absorbable sponge with contrasting agent
US6200328B1 (en) * 1998-05-01 2001-03-13 Sub Q, Incorporated Device and method for facilitating hemostasis of a biopsy tract
US6179860B1 (en) * 1998-08-19 2001-01-30 Artemis Medical, Inc. Target tissue localization device and method
US6056700A (en) * 1998-10-13 2000-05-02 Emx, Inc. Biopsy marker assembly and method of use
US6371904B1 (en) * 1998-12-24 2002-04-16 Vivant Medical, Inc. Subcutaneous cavity marking device and method
US6356782B1 (en) * 1998-12-24 2002-03-12 Vivant Medical, Inc. Subcutaneous cavity marking device and method
US6347241B2 (en) * 1999-02-02 2002-02-12 Senorx, Inc. Ultrasonic and x-ray detectable biopsy site marker and apparatus for applying it

Cited By (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9039763B2 (en) 1997-10-10 2015-05-26 Senorx, Inc. Tissue marking implant
US8157862B2 (en) 1997-10-10 2012-04-17 Senorx, Inc. Tissue marking implant
US9480554B2 (en) 1997-10-10 2016-11-01 Senorx, Inc. Tissue marking implant
US8668737B2 (en) 1997-10-10 2014-03-11 Senorx, Inc. Tissue marking implant
US8292822B2 (en) 1998-06-22 2012-10-23 Devicor Medical Products, Inc. Biopsy localization method and device
US8600481B2 (en) 1998-12-24 2013-12-03 Devicor Medical Products, Inc. Subcutaneous cavity marking device
US9669113B1 (en) 1998-12-24 2017-06-06 Devicor Medical Products, Inc. Device and method for safe location and marking of a biopsy cavity
US7668582B2 (en) * 1998-12-24 2010-02-23 Ethicon Endo-Surgery, Inc. Biopsy site marker
US9380998B2 (en) 1998-12-24 2016-07-05 Devicor Medical Products, Inc. Subcutaneous cavity marking device and method
US8306602B2 (en) 1998-12-24 2012-11-06 Devicor Medical Products, Inc. Biopsy cavity marking device
US8320994B2 (en) 1998-12-24 2012-11-27 Devicor Medical Products, Inc. Biopsy cavity marking device and method
US8320993B2 (en) * 1998-12-24 2012-11-27 Devicor Medical Products, Inc. Subcutaneous cavity marking device
US9492570B2 (en) 1998-12-24 2016-11-15 Devicor Medical Products, Inc. Device and method for safe location and marking of a biopsy cavity
US9649093B2 (en) 1999-02-02 2017-05-16 Senorx, Inc. Cavity-filling biopsy site markers
US8498693B2 (en) 1999-02-02 2013-07-30 Senorx, Inc. Intracorporeal marker and marker delivery device
US9861294B2 (en) 1999-02-02 2018-01-09 Senorx, Inc. Marker delivery device with releasable plug
US8361082B2 (en) 1999-02-02 2013-01-29 Senorx, Inc. Marker delivery device with releasable plug
US8965486B2 (en) 1999-02-02 2015-02-24 Senorx, Inc. Cavity filling biopsy site markers
US9044162B2 (en) 1999-02-02 2015-06-02 Senorx, Inc. Marker delivery device with releasable plug
US9149341B2 (en) 1999-02-02 2015-10-06 Senorx, Inc Deployment of polysaccharide markers for treating a site within a patient
US9237937B2 (en) 1999-02-02 2016-01-19 Senorx, Inc. Cavity-filling biopsy site markers
US9820824B2 (en) 1999-02-02 2017-11-21 Senorx, Inc. Deployment of polysaccharide markers for treating a site within a patent
US8224424B2 (en) 1999-02-02 2012-07-17 Senorx, Inc. Tissue site markers for in vivo imaging
US8626270B2 (en) 1999-02-02 2014-01-07 Senorx, Inc. Cavity-filling biopsy site markers
US8219182B2 (en) 1999-02-02 2012-07-10 Senorx, Inc. Cavity-filling biopsy site markers
US8052708B2 (en) 1999-06-17 2011-11-08 Bard Peripheral Vascular, Inc. Apparatus for the percutaneous marking of a lesion
US8579931B2 (en) 1999-06-17 2013-11-12 Bard Peripheral Vascular, Inc. Apparatus for the percutaneous marking of a lesion
US9579159B2 (en) 1999-06-17 2017-02-28 Bard Peripheral Vascular, Inc. Apparatus for the percutaneous marking of a lesion
US8718745B2 (en) 2000-11-20 2014-05-06 Senorx, Inc. Tissue site markers for in vivo imaging
US8177792B2 (en) 2002-06-17 2012-05-15 Senorx, Inc. Plugged tip delivery tube for marker placement
US8784433B2 (en) 2002-06-17 2014-07-22 Senorx, Inc. Plugged tip delivery tube for marker placement
JP2012139509A (en) * 2002-10-11 2012-07-26 Ion Beam Applications Sa Interstitial marker and device for visualizing the marker through imaging modality
US9848956B2 (en) 2002-11-18 2017-12-26 Bard Peripheral Vascular, Inc. Self-contained, self-piercing, side-expelling marking apparatus
US8639315B2 (en) 2003-05-23 2014-01-28 Senorx, Inc. Marker or filler forming fluid
US8880154B2 (en) 2003-05-23 2014-11-04 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US9801688B2 (en) 2003-05-23 2017-10-31 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US8626269B2 (en) 2003-05-23 2014-01-07 Senorx, Inc. Fibrous marker and intracorporeal delivery thereof
US8447386B2 (en) 2003-05-23 2013-05-21 Senorx, Inc. Marker or filler forming fluid
US20070299339A1 (en) * 2003-07-25 2007-12-27 Rubicor Medical, Inc. Post-biopsy cavity treatment implants and methods
US8092779B2 (en) 2003-07-25 2012-01-10 Rubicor Medical, Llc Post-biopsy cavity treatment implants and methods
US20070135711A1 (en) * 2003-07-25 2007-06-14 Rubicor Medical, Inc. Methods and systems for marking post biopsy cavity sites
US7744852B2 (en) 2003-07-25 2010-06-29 Rubicor Medical, Llc Methods and systems for marking post biopsy cavity sites
US20050019262A1 (en) * 2003-07-25 2005-01-27 Rubicor Medical, Inc. Post-biopsy cavity treatment implants and methods
US7537788B2 (en) 2003-07-25 2009-05-26 Rubicor Medical, Inc. Post-biopsy cavity treatment implants and methods
US20050033157A1 (en) * 2003-07-25 2005-02-10 Klein Dean A. Multi-modality marking material and method
US8491630B2 (en) 2003-07-25 2013-07-23 Encapsule Medical, LLC. Post-biopsy cavity treatment implants and methods
US7780948B2 (en) 2003-07-25 2010-08-24 Rubicor Medical, Llc Post biopsy cavity treatment implants and methods
US7416533B2 (en) 2003-08-13 2008-08-26 Scimed Life Systems, Inc. Marking biopsy sites
US20090054806A1 (en) * 2003-08-13 2009-02-26 Boston Scientific Scimed, Inc. Marking biopsy sites
US7001341B2 (en) * 2003-08-13 2006-02-21 Scimed Life Systems, Inc. Marking biopsy sites
US20050038355A1 (en) * 2003-08-13 2005-02-17 Gellman Barry N. Marking biopsy sites
US7946998B2 (en) 2003-08-13 2011-05-24 Boston Scientific Scimed, Inc. Marking biopsy sites
US20060111646A1 (en) * 2003-08-13 2006-05-25 Gellman Barry N Marking biopsy sites
US7534452B2 (en) 2003-10-16 2009-05-19 Rubicor Medical, Inc. Post-biopsy cavity treatment implants and methods
US20080114329A1 (en) * 2003-10-16 2008-05-15 Rubicor Medical, Inc. Post-biopsy cavity treatment implants and methods
US7819820B2 (en) 2003-11-17 2010-10-26 Bard Peripheral Vascular, Inc. Self contained, self piercing, side-expelling marking apparatus
US8634899B2 (en) 2003-11-17 2014-01-21 Bard Peripheral Vascular, Inc. Multi mode imaging marker
US20080306590A1 (en) * 2004-01-29 2008-12-11 Smart Implant Plc Prosthesis and Method of Manufacturing a Prosthesis
US9060807B2 (en) * 2004-02-06 2015-06-23 Olympus Corporation Light marker for indwelt use in patient's body and for identification of lesions inside patients tubular organ using the light marker
US20110160577A1 (en) * 2004-02-06 2011-06-30 Olympus Corporation Light marker for indwelt use in patients body and for identification of lesions inside patients tubular organ using the light marker
US20050234336A1 (en) * 2004-03-26 2005-10-20 Beckman Andrew T Apparatus and method for marking tissue
US20050273002A1 (en) * 2004-06-04 2005-12-08 Goosen Ryan L Multi-mode imaging marker
US7670378B2 (en) * 2004-06-18 2010-03-02 Aesculap Ag Implant for insertion into a bone cavity or between vertebral bodies
US20060009844A1 (en) * 2004-06-18 2006-01-12 Aesculap Ag & Co. Kg Implant
US20090216115A1 (en) * 2004-07-23 2009-08-27 Calypso Medical Technologies, Inc. Anchoring wirless markers within a human body
US8419656B2 (en) 2004-11-22 2013-04-16 Bard Peripheral Vascular, Inc. Post decompression marker introducer system
US7831293B2 (en) 2005-05-10 2010-11-09 Advanced Clinical Solutions, Inc. Method of defining a biological target for treatment
US20060258933A1 (en) * 2005-05-10 2006-11-16 Advanced Clinical Solutions, Inc. Method of defining a biological target for treatment
US8486028B2 (en) 2005-10-07 2013-07-16 Bard Peripheral Vascular, Inc. Tissue marking apparatus having drug-eluting tissue marker
US20160100910A1 (en) * 2005-11-17 2016-04-14 Breast-Med, Inc. Imaging fiducial markers and methods
US8966735B2 (en) * 2005-11-17 2015-03-03 Breast-Med, Inc. Tissue marker for multimodality radiographic imaging
US8544162B2 (en) * 2005-11-17 2013-10-01 Breast-Med, Inc. Tissue marker for multimodality radiographic imaging
US20100287887A1 (en) * 2005-11-17 2010-11-18 Breast-Med, Inc. Tissue marker for multimodality radiographic imaging
US7702378B2 (en) 2005-11-17 2010-04-20 Breast-Med, Inc. Tissue marker for multimodality radiographic imaging
US9861450B2 (en) * 2005-11-17 2018-01-09 Breast-Med, Inc. Imaging fiducial markers and methods
US20150173848A1 (en) * 2005-11-17 2015-06-25 Breast-Med, Inc. Imaging fiducial markers and methods
US20070110665A1 (en) * 2005-11-17 2007-05-17 Bolan Patrick J Tissue marker for multimodality radiographic imaging
US9241773B2 (en) * 2005-11-17 2016-01-26 Breast-Med, Inc. Imaging fiducial markers and methods
US8064987B2 (en) 2006-10-23 2011-11-22 C. R. Bard, Inc. Breast marker
US8437834B2 (en) 2006-10-23 2013-05-07 C. R. Bard, Inc. Breast marker
US9901415B2 (en) 2006-12-12 2018-02-27 C. R. Bard, Inc. Multiple imaging mode tissue marker
US9579077B2 (en) 2006-12-12 2017-02-28 C.R. Bard, Inc. Multiple imaging mode tissue marker
US9042965B2 (en) 2006-12-18 2015-05-26 C. R. Bard, Inc. Biopsy marker with in situ-generated imaging properties
US8401622B2 (en) 2006-12-18 2013-03-19 C. R. Bard, Inc. Biopsy marker with in situ-generated imaging properties
US20090149746A1 (en) * 2007-11-19 2009-06-11 Rubicor Medical, Inc. Post-biopsy cavity treatment implants and methods
US8311610B2 (en) 2008-01-31 2012-11-13 C. R. Bard, Inc. Biopsy tissue marker
US8849377B2 (en) * 2008-03-03 2014-09-30 Ethicon Endo-Surgery, Inc. Intraluminal tissue markers
US20090221913A1 (en) * 2008-03-03 2009-09-03 Ethicon Endo-Surgery, Inc. Intraluminal tissue markers
US9327061B2 (en) 2008-09-23 2016-05-03 Senorx, Inc. Porous bioabsorbable implant
US8670818B2 (en) 2008-12-30 2014-03-11 C. R. Bard, Inc. Marker delivery device for tissue marker placement
US9943704B1 (en) 2009-01-21 2018-04-17 Varian Medical Systems, Inc. Method and system for fiducials contained in removable device for radiation therapy
USD715442S1 (en) 2013-09-24 2014-10-14 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716450S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD716451S1 (en) 2013-09-24 2014-10-28 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
USD715942S1 (en) 2013-09-24 2014-10-21 C. R. Bard, Inc. Tissue marker for intracorporeal site identification
US9795455B2 (en) 2014-08-22 2017-10-24 Breast-Med, Inc. Tissue marker for multimodality radiographic imaging

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US8320993B2 (en) 2012-11-27 grant
US6356782B1 (en) 2002-03-12 grant
US20050080339A1 (en) 2005-04-14 application
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US20020035324A1 (en) 2002-03-21 application
US20140194741A1 (en) 2014-07-10 application
US20130066195A1 (en) 2013-03-14 application
US20050080337A1 (en) 2005-04-14 application
US8600481B2 (en) 2013-12-03 grant
US7668582B2 (en) 2010-02-23 grant
US20140051996A1 (en) 2014-02-20 application
US20050085724A1 (en) 2005-04-21 application
US20050080338A1 (en) 2005-04-14 application
US20120330153A1 (en) 2012-12-27 application
US20060036159A1 (en) 2006-02-16 application
US9380998B2 (en) 2016-07-05 grant
US8306602B2 (en) 2012-11-06 grant
US20050059888A1 (en) 2005-03-17 application
US20060079770A1 (en) 2006-04-13 application

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