US20020045937A1 - Sarfarazi elliptical accommodative intraocular lens for small incision surgery - Google Patents

Sarfarazi elliptical accommodative intraocular lens for small incision surgery Download PDF

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US20020045937A1
US20020045937A1 US08/176,914 US17691494A US2002045937A1 US 20020045937 A1 US20020045937 A1 US 20020045937A1 US 17691494 A US17691494 A US 17691494A US 2002045937 A1 US2002045937 A1 US 2002045937A1
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lens
lens assembly
anterior
posterior
mm
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US6423094B1 (en
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Faezeh M. Sarfarazi
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Kile Bradford E
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Kile Bradford E
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Priority to US08/176,914 priority patent/US6423094B1/en
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Priority claimed from US10/201,615 external-priority patent/US20040015236A1/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1629Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing longitudinal position, i.e. along the visual axis when implanted
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1613Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1648Multipart lenses

Abstract

An elliptical accommodative intraocular lens assembly is provided for placement in the evacuated capsular bag of the posterior chamber of an eye after a small incision capsulorhexis, such that as the capsular bag is pulled and released by ciliary muscles, the lenses approach and withdraw from each other to provide focal accommodation.

Description

    FIELD OF THE INVENTION
  • This invention relates to intraocular lenses for implanting in the capsular bag of the posterior chamber of the eye after an anterior capsulorhexis. After implantation the lens makes use of the ciliary muscle to adjust the refractive power of the lens. [0001]
  • BACKGROUND OF THE INVENTION
  • Cataract extraction is the most common ophthalmic surgical procedure performed in the United States. Extracapsular cataract extraction involves cutting a portion of the anterior capsule (anterior capsulorhexis) followed by removal of the nucleus. Alternatively, a probe may be inserted through the anterior capsule and ultrasonically vibrated, transforming lens material into an emulsion is then irrigated and aspirated from the capsular bag (phacoemulsification). After removal of the natural lens, images no longer focus on the retina and a replacement lens must be provided for clear vision. Replacement lenses can be glasses, contact lenses or intraocular lenses. Of these, intraocular lenses give the greatest convenience and undistorted vision, however, for insertion of a lens, the size of the incision is dictated by the size of the implant rather than requirements of removing the natural lens. Replacement lenses, however, lack the ability of a natural lens to accommodatively focus on near and far objects. [0002]
  • When a person looks at an object, light is reflected from the object through the cornea, the aqueous humor, through the pupil and into the lens which converges the light through the vitreous body onto the retina. To clearly focus on near objects, light rays must be bent more. To accomplish this the lens becomes more curved and thicker. Most of this change comes, from pulling and relaxing the capsular bag at its equator. The equator of the bag is attached to the ciliary muscle by filaments called the zonules of Zinn which rn are in turn attached to the ciliary muscle. When looking at an object in the distance, the ciliary muscle relaxes and expands, thereby pulling on the zonules, flattening the capsule and lens. When looking at a near object, the ciliary en muscle tenses and contracts moving the muscle sightly inward and relaxing the pull on the zonules, allowing the capsular bag to become more curved and thickened from front to back. The lens itself is composed of interlocking fibers which affect the elastic movement of the lens so that as the lens changes shape the fibers alter their curvature. As a person ages, the accommodative ability of the lens decreases which changes in the eye. Age related eye changes include thickening of the lens, an increase in the amount of insoluble protein in the lens, a migration in the points of attachment of the zonules away from the equator of the capsule, and partial liquefaction of the vitreous body. [0003]
  • Lenses are made from transparent material having the shape of a body of rotational symmetry, such as a sphere. The degree of curvature of the surface is inversely proportional to the radius of curvature and the focal length. Parallel light rays converge after being refracted through a convex surface and diverge after being refracted through a concave surface. Refractive power of a lens is dependent upon the refractive index of the lens material and the lens curvature. A simple lens has two sides, each with a curvature. Two lenses separated by a given distance, can be considered as one thick lens having two foci and two principal planes. The focal length of the system is the product of their focal lengths (f[0004] 1, f2) divided by the sum of their focal lengths minus the distance (d) between them i.e.
  • F=(f 1 f 2)/(f 1 +f 2 −d)
  • When the space between the lenses is not a vacuum but contains a substance, the amount subtracted from the sum of the focal length is divided by the refractive index (n) of that substance.[0005]
  • F=(f 1 f 2)/(f 1 +f 2 −d/n)
  • The refractive power of a lens system is given by the inverse of the focal length. By using two fixed lenses and varying the distance between them, a system of variable focal length can be constructed. If the curvature of one or both of the lens surfaces increases as the distance between lenses is increased, and decreases as the distance between the lenses is decreased, the change in focal length is enhanced. [0006]
  • Several attempts have been made to provide the eye with focal length accommodation. The most familiar of these is a bi or multi-focal lens. These are used in glasses, contacts, and intraocular lenses but have a disadvantage in that the focal accommodation is dependent upon direction of focus. [0007]
  • U.S. Pat. No. 4,254,509 discloses a lens which takes advantage of the ciliary muscle. However, this lens is placed in the anterior chamber of the eye. Such implants are at times accompanied by complications such as damage to the vascular iris. [0008]
  • U.S. Pat. No. 4,253,199 discloses a lens attached directly to the ciliary body. The lens is in a more natural position but requires suturing to the ciliary body risking massive rupture during surgery and bleeding from the sutures. [0009]
  • U.S. Pat. No. 4,685,922, incorporated herein by reference, discloses a chambered lens system for which the refractive power can be changed. Such alteration is permanent, accomplished by rupture of the chambers. [0010]
  • U.S. Pat. No. 4,790,847 provides a single lens for in capsular bag implantation using rearwardly biased haptics which engage the capsular bag at its equator and move the lens forward and backward upon contraction and relaxation of the ciliary muscles. [0011]
  • U. S. Pat. No. 4,842,601, incorporated herein by reference, discloses a two section deformable lens assembly for implanting in the capsular bag. The lens allows division of refractive power and takes advantage of the action of the ciliary body and zonules on the capsular bag. This lens system is assembled after insertion. [0012]
  • U.S. Pat. No. 4,892,543 discloses another two lens assembly for placement in the posterior chamber, possibly in the bag where the capsular bag is not removed. This lens allows dividing the refractive power between two lenses and introduces a variable focal length in one of the lenses by compressing a flexible wall of one lens against the convex surface of the second fixed lens. This requires that the first and second lens be in substantially adjacent positions. [0013]
  • U.S. Pat. No. 4,932,966, incorporated herein by reference, presents an accommodative lens in which two lenses joined at their periphery enclosed a fluid filled sack, accommodation being accomplished selectively changing the fluid pressure in the sac. One lens is a rigid base lens and the other lens is membrane-like, the equatorial diameter of the lens assembly being substantially that of a dilated pupil and is supported by bladders or haptics. [0014]
  • BRIEF SUMMARY OF THE INVENTION
  • The present invention provides dual and thick lens optics, capable of accommodating focus at a range of distances in a simple unitary structure. It uses the eye capsule's natural shaping from the ciliary body to accommodate the focus. Embodiments provide for insertion into a small incision, natural centricity, and increased focusing of the components.[0015]
  • DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a cross sectional view of the eye with an accomodative lens of the invention in place. [0016]
  • FIG. 2 is a vertical sectional view of an eye. [0017]
  • FIG. 3 is a partial sectional view showing an intraocular lens in accordance with the invention within the capsular bag when the eye is focused on a near object. [0018]
  • FIG. 4 is a partial sectional view showing the intraocular lens of FIG. 3 when the eye is focused on a distant object. [0019]
  • FIG. 5 is a partial sectional view showing an alternate embodiment. [0020]
  • FIG. 6 is a schematic side view of the natural lens. [0021]
  • FIG. 7 is a side view of a thick lens embodiment of the lens assembly. [0022]
  • FIG. 8 is a perspective sectional view of the embodiment of FIG. 3. [0023]
  • DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • FIG. 2 shows a cross section of the eye. As light enters the eye it passes through the cornea [0024] 1; through the aqueous humor in the anterior chamber 2; through the pupil located centric of iris 3; through the anterior wall of the capsular bag 6 a; is convergently refracted by the lens 8; passes through the posterior wall of capsular bag 6 b; through the vitreous humor 9 to the retina 10 at the fovea 11. The shape of the lens capsule is controlled by ciliary muscle 4 attached to the capsule by filaments called zonules 5.
  • The natural lens, shown in FIG. 6, has a central biconvex nuclear portion [0025] 26 surrounded by a concavo-convex menisci 27 a and b. Lenses which are bi convex converge light rays. Lenses which are concavo-convex have a diverging effect on light rays. Therefore the menisci of the natural lens provides a moderating effect on the converging nucleus. The anterior-posterior or polar diameter of the lens is about 5 mm. The equatorial diameter is about 9 mm.
  • When the natural lens [0026] 8 is removed through capsulorhexis 25, the intraocular implant shown in FIGS. 3 and 4 can restore focusing. The implant has an anterior lens 12 with an anterior surface 14 and a posterior lens 13 with an posterior surface 15. Extending from and connecting the equatorial perimeters of the anterior and posterior lenses is a flexible cell wall 16 forming a discoid cell 17 having an equatorial diameter substantially the same as the capsule 6. Cell 17 formed by the two lenses 12 and 13 is filled with a fluid (gas or liquid) such as air after implantation. Pressure around the equator of the cell supports the lens assembly in place.
  • FIG. 8 shows the same lens assembly having a cell equatorial diameter of D[0027] e, a cell polar diameter of Dp, and a polar axis PaPp. The equatorial perimeter 24 of the anterior lens 12 is substantially the size of a pupil (4-5 mm.).
  • Although the lenses may be rigid or flexible, flexible lenses can provide greater accommodation. Anterior and posterior lenses, if rigid can be made out of a biocompatible, transparent material such as PMMA (polymethyl methacrylate), HEMA (hydroxyethyl methacrylate), polysulfones, polycarbonates, or a silicon polymer (polydimethyl siloxanes). Materials for a soft lens would include gel forming polymers such as silica hydrogels, polysaccharides such as hyaluronic acid, or a transparent, lens-shaped sack of polyvinyl alcohol. The equatorial diameter of the anterior lens is about the size of a dilated pupil or 5 mm. Posterior and anterior lenses have a thickness of 1 to 1.5 mm. For a typical eye the anterior radius of curvature for the anterior lens is between 8 and 14 mm., and the posterior radius of curvature for the posterior lens is between 4 and 7 mm. The curvature of both faces of each lens can be altered to correct for differences in the shape of the eye (i.e. myopia). Since both lenses are converging lenses with a space between them, focal length and power is divided between them, however, if desired, the power could be in one lens. The cell wall [0028] 16 has a thickness of 0.1 mm., and can be made of a methacrylate, silicon polymer or other biocompatible, flexible material. The discoid shape is preferably an ellipsoid having a polar diameter of about 5 mm. and an equatorial diameter of 9 mm. when filled. When the ciliary muscles 4 relax and swell, the zonnules 5 pull on the equator of the capsule 6, the lens assembly flattens increasing its equatorial diameter and decreasing its polar diameter thus decreasing the distance between the two lenses and altering the power of the lens assembly. If the lenses are made from a soft material, such as a lens shaped sack cn filled with polyvinyl alcohol, they also pull into a flatted form enhancing optical power change. To facilitate inserting the lens assembly through an incision, soft lenses could be made of a gel forming polymer and dehydrated (thus shrinking them) and the cell left unfilled until after insertion. After insertion fluids from the surrounding tissue could reconstitute the lenses and fill the cell. The cell could also be filled with a microtube or hypodermic.
  • FIG. 5 shows an alternative form of the invention. In capsular bag [0029] 6 is a lens assembly having an anterior lens 19 with anterior curved surface 20 and a posterior lens 21 with posterior curved surface 22. Extending from and connecting the equatorial perimeters of the anterior and posterior lenses is a flexible, resilient cell wall 23 having a diameter substantially the same as lenses 19 and 21. The substantially paraboloid cell 24 thus formed may be filled with a fluid (gas or liquid) such as air. Two or more resilient haptics may be substituted for the cell wall to space the lenses and bias them against the capsular poles. The springlike action of the haptics or cell wall bias the lenses against the surface of the capsular poles supporting the lens assembly in place. As the capsular bag is pulled and released by the ciliary muscles, the lenses approach and withdraw from each other to provide focal accommodation. If a soft lens is used a support ring may be provided around the equator of the lens.
  • FIG. 7 shows an embodiment of the invention comprising a thick lens having an anterior surface [0030] 29 and a posterior surface 30. The body of the lens 28 is substantially paraboloid. Paraboloid for the purposes of this invention includes cylindrical, hyperboloid and paraboloid. The lens is made of a resilient material to bias the anterior and posterior surfaces against the capsular poles. This springlike action supports the lens in place such that when the capsular bag is pulled and released, the anterior and posterior surfaces approach and withdraw from each other providing focal accommodation.
  • The lens assemblies shown in FIG. 5 and [0031] 7 can be inserted through an incision substantially the width of the lens then turned or be compressed for insertion.

Claims (44)

What is claimed is:
1. An accommodative intraocular lens assembly for placement in the capsular bag of the posterior chamber of an eye from which the natural lens has been removed comprising:
an anterior converging lens having a convex anterior surface and a posterior surface, an equatorial perimeter and an optic axis;
a posterior lens lens having an anterior surface, a posterior surface, an equatorial perimeter and an optic axis substantially parallel to said optic axis of said anterior lens; and
a cell wall extending from said equatorial perimeter of said anterior lens to said equatorial perimeter of said posterior lens forming a substantially closed cell for containing a fluid, such that as said capsular bag is pulled and released by ciliary muscles, said lenses approach and withdraw from each other to provide focal accommodation.
2. The lens assembly of claim 1 wherein said posterior lens is a converging lens.
3. The lens assembly of claim 1 wherein said cell is substantially paraboloid.
4. The lens assembly of claim 1 wherein said cell is substantially discoid.
5. The lens assembly of claim 4 wherein said cell is substantially ellipsoid.
6. The lens assembly of claim 1 wherein said anterior and posterior lenses have equatorial diameters in the range of 3 to 7 mm.
7. The lens assembly of claim 1 wherein said anterior and posterior lenses have equatorial diameters in the range of 4 to 5 mm.
8. The lens assembly of claim 4 wherein said cell has an equatorial diameter in the range of 9 to 14 mm.
9. The lens assembly of claim 4 wherein said cell has an equatorial diameter in the range of 9 to 10 mm.
10. The lens assembly of claim 1 wherein said anterior surface of said anterior lens is non-spherically convex.
11. The lens assembly of claim 2 wherein said posterior surface of said posterior lens is non-spherically convex.
12. The lens assembly of claim 1 wherein said anterior lens has an polar diameter in the range of 1.0 and 1.5 mm.
13. The lens assembly of claim 1 wherein said anterior surface of said anterior lens has a radius of curvature in the range of 8 and 14 mm.
14. The lens assembly of claim 2 wherein said posterior surface of said posterior lens has a radius of curvature in the range of 4.5 and 7 mm.
15. The lens assembly of claim 4 wherein said wall has a thickness of about 0.1 mm.
16. The lens assembly of claim 1 wherein at least one of said lenses is rigid.
17. The lens assembly of claim 16 wherein said lens is made from a polymer chosen from group consisting of methacrylates, polycarbonates, siloxanes and polysulfones.
18. The lens assembly of claim 1 wherein at least one of said lenses is pliable.
19. The lens assembly of claim 18 wherein said lens is made from a material chosen from the group consisting of gel forming polymers and polyvinyl alcohols.
20. The lens assembly of claim 4 wherein said fluid is transported to said cell after insertion into said capsular bag.
21. The lens assembly of claim 18 wherein said thickness and radius of curvature of said lens changes as said Cn capsular bag is pulled and released by ciliary muscles.
22. The lens assembly of claim 1 wherein the distance between said anterior and posterior lenses is in the range of 3.5 to 5 mm.
23. The lens assembly of claim 1 wherein the distance between the anterior and posterior lenses is about 4 mm.
24. The lens assembly of claim 3 wherein said cell wall is resilient such that said anterior and posterior lenses are biased against the anterior and posterior poles of said capsular bag.
25. The lens assembly of claim 24 wherein said cell wall is compressible for insertion into an incision having a length in the range of 2 to 4 mm.
26. The lens assembly of claim 1 wherein the power of said assembly is divided between said anterior and posterior lenses.
27. The lens assembly of claim 1 wherein the power of said assembly is equal to the power of one of said lenses.
28. The lens assembly of claim 2 wherein said anterior surface of said anterior lens has a radius of curvature in the range of 17.7 and 17.9 mm.
29. The lens assembly of claim 2 wherein said posterior surface of said posterior lens has a radius of curvature in the range of 10.6 and 10.8 mm.
30. The lens assembly of claim 1 wherein said cell wall is made of a material chosen from the group consisting of methacrylates polymers, silicon polymers and olefin polymers.
31. The lens assembly of claim 18 wherein said lens is provided with an equatorial support ring.
32. The lens assembly of claim 19 wherein said lens is dehydrated prior to insertion.
33. An accommodative intraocular lens assembly for placement in the capsular bag of the posterior chamber of an eye from which the natural lens has been removed comprising:
a resilient paraboloid having a convex anterior surface and a posterior surface such that said anterior surface is biased against the anterior pole of said capsular bag and said posterior surface is biased against the posterior pole of said capsular bag, such that as said capsular bag is pulled and released by ciliary muscles, said surfaces approach and withdraw from each other to provide focal accommodation.
34. The lens assembly of claim 33 wherein said posterior surface is convex.
35. The lens assembly of claim 33 wherein said anterior and posterior surfaces have diameters in the range of 4 to 5 mm.
36. The lens assembly of claim 33 wherein at least one said surface is non-spherically convex.
37. The lens assembly of claim 33 wherein said optic made from a polymer chosen from group consisting of methacrylates, polycarbonates, siloxanes, polysulfones, olifin polymers, gel forming polymers and polyvinyl alcohols.
38. The lens assembly of claim 33 wherein the radius of curvature and distance between said anterior and posterior surfaces changes as said capsular bag is pulled and released by ciliary muscles.
39. The lens assembly of claim 33 wherein the distance between said anterior and posterior surfaces lenses is in the range of 3.5 to 5 mm.
40. The lens assembly of claim 33 wherein said optic is compressible for insertion into an incision having a length in the range of 2 to 4 mm.
41. The lens assembly of claim 33 wherein said anterior surface has a radius of curvature in the range of 17.7 and 17.9 mm.
42. The lens assembly of claim 34 wherein said posterior surface has a radius of curvature in the range of 10.6 and 10.8 mm.
43. The lens assembly of claim 37 wherein said lens is dehydrated prior to insertion.
44. The lens assembly of claim wherein said wall is made from a material chosen from the group consisting of methacrylates and olifins.
US08/176,914 1991-11-18 1994-01-03 Accommodative lens formed from sheet material Expired - Fee Related US6423094B1 (en)

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US07/793,470 US5275623A (en) 1991-11-18 1991-11-18 Elliptical accommodative intraocular lens for small incision surgery
US08/176,914 US6423094B1 (en) 1991-11-18 1994-01-03 Accommodative lens formed from sheet material

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US08/176,914 US6423094B1 (en) 1991-11-18 1994-01-03 Accommodative lens formed from sheet material
US10/201,615 US20040015236A1 (en) 1991-11-18 2002-07-22 Sarfarazi elliptical accommodative intraocular lens for small incision surgery

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US20050267575A1 (en) * 2001-01-25 2005-12-01 Nguyen Tuan A Accommodating intraocular lens system with aberration-enhanced performance
US20060184244A1 (en) * 2005-02-14 2006-08-17 Nguyen Tuan A Biasing system for intraocular lens
US20070050025A1 (en) * 2001-01-25 2007-03-01 Nguyen Tuan A Hydraulic configuration for intraocular lens system
US20070100444A1 (en) * 2005-10-28 2007-05-03 Brady Daniel G Haptic for accommodating intraocular lens
US20070108643A1 (en) * 2001-01-25 2007-05-17 Gholam-Reza Zadno-Azizi Single-piece accommodating intraocular lens system
US7871437B2 (en) 2006-12-22 2011-01-18 Amo Groningen B.V. Accommodating intraocular lenses and associated systems, frames, and methods
US8187325B2 (en) 2001-01-25 2012-05-29 Visiogen, Inc. Materials for use in accommodating intraocular lens system
US8377123B2 (en) 2004-11-10 2013-02-19 Visiogen, Inc. Method of implanting an intraocular lens
US8556967B2 (en) 1999-04-09 2013-10-15 Faezeh Mona Sarfarazi Interior bag for a capsular bag and injector
US20150305858A1 (en) * 2014-04-29 2015-10-29 Chukyo Medical Co., Inc. Intraocular lens
US9198752B2 (en) 2003-12-15 2015-12-01 Abbott Medical Optics Inc. Intraocular lens implant having posterior bendable optic
US9220590B2 (en) 2010-06-10 2015-12-29 Z Lens, Llc Accommodative intraocular lens and method of improving accommodation
US9364318B2 (en) 2012-05-10 2016-06-14 Z Lens, Llc Accommodative-disaccommodative intraocular lens
US9814570B2 (en) 1999-04-30 2017-11-14 Abbott Medical Optics Inc. Ophthalmic lens combinations
US10206773B2 (en) 2002-12-05 2019-02-19 Johnson & Johnson Surgical Vision, Inc. Accommodating intraocular lens and method of manufacture thereof
US10512535B2 (en) 2016-08-24 2019-12-24 Z Lens, Llc Dual mode accommodative-disaccomodative intraocular lens
US10524900B2 (en) 2015-11-06 2020-01-07 Z Lens, Llc Accommodative intraocular lens and method of improving accommodation

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US20040015236A1 (en) * 1991-11-18 2004-01-22 Sarfarazi Faezeh M. Sarfarazi elliptical accommodative intraocular lens for small incision surgery
US7662179B2 (en) 1999-04-09 2010-02-16 Sarfarazi Faezeh M Haptics for accommodative intraocular lens system
US20030060881A1 (en) 1999-04-30 2003-03-27 Advanced Medical Optics, Inc. Intraocular lens combinations
US6818158B2 (en) * 2001-01-25 2004-11-16 Visiogen, Inc. Accommodating intraocular lens system and method of making same
US6884261B2 (en) 2001-01-25 2005-04-26 Visiogen, Inc. Method of preparing an intraocular lens for implantation
IL141529D0 (en) * 2001-02-20 2002-03-10 Ben Nun Yehoshua Intraocular lens with scleral fixation capability
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