US2001046A - Medicinal preparation - Google Patents
Medicinal preparation Download PDFInfo
- Publication number
- US2001046A US2001046A US711065A US71106534A US2001046A US 2001046 A US2001046 A US 2001046A US 711065 A US711065 A US 711065A US 71106534 A US71106534 A US 71106534A US 2001046 A US2001046 A US 2001046A
- Authority
- US
- United States
- Prior art keywords
- preparation
- application
- counter
- skin
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title description 34
- 239000000243 solution Substances 0.000 description 15
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 239000000341 volatile oil Substances 0.000 description 12
- 239000002085 irritant Substances 0.000 description 11
- 230000001476 alcoholic effect Effects 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 239000003921 oil Substances 0.000 description 8
- 239000004615 ingredient Substances 0.000 description 7
- 239000000344 soap Substances 0.000 description 7
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 6
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 6
- 230000009286 beneficial effect Effects 0.000 description 6
- 229940041616 menthol Drugs 0.000 description 6
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 5
- 241000723346 Cinnamomum camphora Species 0.000 description 5
- 229960000846 camphor Drugs 0.000 description 5
- 229930008380 camphor Natural products 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 235000019645 odor Nutrition 0.000 description 5
- 239000004264 Petrolatum Substances 0.000 description 4
- 229940066842 petrolatum Drugs 0.000 description 4
- 235000019271 petrolatum Nutrition 0.000 description 4
- 244000166124 Eucalyptus globulus Species 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 241000779819 Syncarpia glomulifera Species 0.000 description 3
- 241000246358 Thymus Species 0.000 description 3
- 235000007303 Thymus vulgaris Nutrition 0.000 description 3
- 230000036407 pain Effects 0.000 description 3
- 239000001739 pinus spp. Substances 0.000 description 3
- 239000001585 thymus vulgaris Substances 0.000 description 3
- 229940036248 turpentine Drugs 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000834 fixative Substances 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 208000004296 neuralgia Diseases 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 206010016334 Feeling hot Diseases 0.000 description 1
- 208000010040 Sprains and Strains Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 239000003517 fume Substances 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229940060184 oil ingredients Drugs 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 239000008149 soap solution Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Definitions
- m invention relates to a medicinal preparaon.
- the object of the invention is to provide a novel medicinal preparation for use as a beneficial penetrant and inhalant in the treatment of colds, congestion in the chest and throat, and for affording relief to many mild pains, such as those produced by neuralgia and strains, and the present preparation is characterized by its solid stainless form which facilitates the application and use thereof, and by the potency, and lasting qualitiw of its odor and vapor, enabling more beneficial effects to be obtained than with other preparations of this general character of which I am aware.
- the invention consists in the medicinal preparation hereinafter preparation objectionable in some instances because of the grease and the stains left on theclothing or bedding coming in contact with the applied preparation.
- the application of heat to the preparation has been prescribed in order to release the de sired vapors to obtain the best relief.
- the present invention contemplates a medicinal preparation for use in the treatment of colds and congestion inthe chest and throat by external application and also which maybe used as a successful inhalant in the treatment of inflammation in the respiratory passages without the necessity of the application of heat'to effect satisfactory release of the necessary amounts of vapors fromthe counter-irritants and essential oils embodied in the preparation.
- Menthol 4 parts by weight Camphor 8 parts by weight 011 of turpentine 4 parts by volume 011 of eucalyptus I 2 parts by volume Oil of thyme (white) 1 part by volume Alcohol 78.5 parts by volume Stearic acid. 4.87 parts by weight Sodium hydroxide 1.1 parts by weight Amber dye solution 2.5 parts by volume Inaccordance with the preferred process, the 4.87 parts by weight of stearlc acid are dissolved 11162.8 parts of alcohol, the latter representing 80% of the total amount of alcohol to be used in the completed-product. 1.1 parts by weight of sodium hydroxide are then dissolved in 15.? parts by volume ofalcohol, the latter representing 20% of the total amount of alcohol to be contained in the product. The stearlc acid solution and the sodium hydroxide solution are then separately warmed to approximately 60 C. and then mixed together. During the digestion of the mixture of the stearic acid solution and the sodium hydroxide solution and the formation of a soap,
- the present medicinal preparation produced as above. described and embodying the amber dye and is characterized by the potent odor .of the counter-irritants and essential oils embodied therein.
- the preparation In the treatment of colds and congestion in the throat and chest the preparation is applied externally, and when rubbed on the skin the contacting portions of the cake liquify under the heat of the body, enabling very efiicient application of an alcoholic solution of the ingredients to be applied. Because of the fact that the ingredients are readily soluble in the alcohol, an even distribution of the ingredients is obtained throughout the alcoholic solution, and as a result upon application a very even distribution of the ingredients over the surface of the skin is obtained.
- the alcohol produces a beneficial eifect upon the surface of the skin, contributing to the ease and efilciency with which the counter-irritants are enabled to penetrate into the skin, and as a result a characteristic sensation of cooling followed by a slight feeling of warmth and a flushing of the skin is experienced by the patient.
- most efiicient counter-irritation is produced, setting up nervous reflexes from the skin and producing beneficial results to the patient in relieving the cold and congestion.
- One advantage of the present preparation resides in the fact that it may be applied without liability of staining the bedding or clothing with which it may come in contact, and in addition its application is much more pleasing than the application of the greasy petrolatum base preparations heretofore used.
- the thin film covering the skin is practically invisible, thus enabling the preparation to be conveniently applied to the forehead and other parts of the face and neck during business hours and without embarrassment to the patient.
- the present preparation When used as an inhalant the present preparation may be either applied directly to a portion of the body or may be applied to a handkerchief or pillow without any liability of soiling, andthe character of the ingredients of the present preparation contributes greatly to the efllciency of the material both as an inhalant and as a penetrant.
- the present preparation possesses the property of holding the vapors and odors of the essential oils and of the counter-irritants for several times as long as prior comparative preparations, utilizing the petrolatumbase, and I attribute this result to the action of the alcoholic solution of soap acting as a fixative for the counter-irritantsand essential oils.
- the patient is exposed to the fumes from the preparation for a relatively long period of time, so that exceedingly beneficial results have been obtained.
- the lasting properties of the preparation In addition to the lasting properties of the preparation,
- the alcoholic soap solution contributes to the potency of the vapors given ofi, and comparative tests have shown that the potency is several times that of comparative prior preparations embodying a petrolatum base. I attribute this result to the action of the alcohol in completely dissolving the 2,001,048 solution resembles a cake or stick of solid vaseline.
- the present preparation In addition to the use of the present preparation as an effective rub and penetrant, and in addition to its use as an inhalant alone or as a combined inhalant and rub, the present preparation possesses characteristics which render its use valuable as a liniment in the treatment of mild pains such as neuralgia and in the treatment of sprains and the like,.and upon application and rubbing into the affected part, the alcoholic solution of the counter-irritants and essential oils penetrates well and offers substantial relief to the ailment.
- a medicinal preparation for application to the skin as a penetrant and also for use as an inhalant comprising an alcoholic solution of a soap in solidified form having dissolved therein a counter-irritant and menthol, and capable of liquification upon application to the skin under the influence of body heat to thereby deposit thereon a film.
- a medicinal preparation for application to the skin as a penetrant and also useful as an inhalant comprising an alcoholic solution of a soap in solidified form having dissolved therein camphor, menthol, oil of turpentine, oil of eucalyptus and oil of thyme, and capable of liquification upon application to the skin under the infiuence of body heat to thereby deposit thereon a 3.
- a medicinal preparation for application to the skin as a penetrant and also useful as an inhalant said preparation comprising an alcoholic solution of a soap in solidified form having dissolved therein an inhalant and a counter-irritant, said base possessing fixative properties for retarding rapid dissipation of the vapors emitted therefrom.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
Description
Patented May 14, 1935* UNITED ,"STATES,
, IEEDICINAL PREPARATION William E. Welch, Dayton, Ohio, lllllllll' to B. J.
Baker 8r Company, Inc.,
Boston, Man. a corporation of hnsetts, and International Proprietaries' Incorporated. Dayton, Ohio, a corporation of Delaware g No Drawing. Application February 1d,- 19,
Serial N0. 711,035 I 3Clalms.
m invention relates to a medicinal preparaon. v
The object of the invention is to provide a novel medicinal preparation for use as a beneficial penetrant and inhalant in the treatment of colds, congestion in the chest and throat, and for affording relief to many mild pains, such as those produced by neuralgia and strains, and the present preparation is characterized by its solid stainless form which facilitates the application and use thereof, and by the potency, and lasting qualitiw of its odor and vapor, enabling more beneficial effects to be obtained than with other preparations of this general character of which I am aware.
With this general object in view, and such others as may hereinafter appear, the invention consists in the medicinal preparation hereinafter preparation objectionable in some instances because of the grease and the stains left on theclothing or bedding coming in contact with the applied preparation. In order to satisfactorily employ such preparations as inhalants for the treatment of inflammation in the respiratory passages, the application of heat to the preparation has been prescribed in order to release the de sired vapors to obtain the best relief.
The present invention contemplates a medicina1 preparation for use in the treatment of colds and congestion inthe chest and throat by external application and also which maybe used as a successful inhalant in the treatment of inflammation in the respiratory passages without the necessity of the application of heat'to effect satisfactory release of the necessary amounts of vapors fromthe counter-irritants and essential oils embodied in the preparation. g
I'have found that ,a most satisfactory base in which thecounter-irritants and essential oils may.
be embodied comprises an alcoholic solution of a ,soap. This base has beenfound to increase by many times the potency of the vapors from the essential .oils and from the counter -irritants as well as the pungency thereof, and in addition appears to actas a fixativefor the odors and vapors from the essential oils and counter-irritants, thereby eflectively main the preparation after application in efficient vapor emitting conditionfor far greater periods of time than comparative preparations in which a petrolatum base well as other essential oils and alcoholic solutions of other soaps.
Menthol 4: parts by weight Camphor 8 parts by weight 011 of turpentine 4 parts by volume 011 of eucalyptus I 2 parts by volume Oil of thyme (white) 1 part by volume Alcohol 78.5 parts by volume Stearic acid. 4.87 parts by weight Sodium hydroxide 1.1 parts by weight Amber dye solution 2.5 parts by volume Inaccordance with the preferred process, the 4.87 parts by weight of stearlc acid are dissolved 11162.8 parts of alcohol, the latter representing 80% of the total amount of alcohol to be used in the completed-product. 1.1 parts by weight of sodium hydroxide are then dissolved in 15.? parts by volume ofalcohol, the latter representing 20% of the total amount of alcohol to be contained in the product. The stearlc acid solution and the sodium hydroxide solution are then separately warmed to approximately 60 C. and then mixed together. During the digestion of the mixture of the stearic acid solution and the sodium hydroxide solution and the formation of a soap,
the camphor, menthol, the oil of turpentine, the.
oil of eucalyptus, the oil of thyme, and the dye The present medicinal preparation produced as above. described and embodying the amber dye and is characterized by the potent odor .of the counter-irritants and essential oils embodied therein. In the treatment of colds and congestion in the throat and chest the preparation is applied externally, and when rubbed on the skin the contacting portions of the cake liquify under the heat of the body, enabling very efiicient application of an alcoholic solution of the ingredients to be applied. Because of the fact that the ingredients are readily soluble in the alcohol, an even distribution of the ingredients is obtained throughout the alcoholic solution, and as a result upon application a very even distribution of the ingredients over the surface of the skin is obtained. The alcohol produces a beneficial eifect upon the surface of the skin, contributing to the ease and efilciency with which the counter-irritants are enabled to penetrate into the skin, and as a result a characteristic sensation of cooling followed by a slight feeling of warmth and a flushing of the skin is experienced by the patient. As a result most efiicient counter-irritation is produced, setting up nervous reflexes from the skin and producing beneficial results to the patient in relieving the cold and congestion.
One advantage of the present preparation resides in the fact that it may be applied without liability of staining the bedding or clothing with which it may come in contact, and in addition its application is much more pleasing than the application of the greasy petrolatum base preparations heretofore used. In addition, after application the thin film covering the skin is practically invisible, thus enabling the preparation to be conveniently applied to the forehead and other parts of the face and neck during business hours and without embarrassment to the patient.
When used as an inhalant the present preparation may be either applied directly to a portion of the body or may be applied to a handkerchief or pillow without any liability of soiling, andthe character of the ingredients of the present preparation contributes greatly to the efllciency of the material both as an inhalant and as a penetrant. Experience has shown that the present preparation possesses the property of holding the vapors and odors of the essential oils and of the counter-irritants for several times as long as prior comparative preparations, utilizing the petrolatumbase, and I attribute this result to the action of the alcoholic solution of soap acting as a fixative for the counter-irritantsand essential oils. As a result, after application the patient is exposed to the fumes from the preparation for a relatively long period of time, so that exceedingly beneficial results have been obtained. In addition to the lasting properties of the preparation,
the alcoholic soap solution contributes to the potency of the vapors given ofi, and comparative tests have shown that the potency is several times that of comparative prior preparations embodying a petrolatum base. I attribute this result to the action of the alcohol in completely dissolving the 2,001,048 solution resembles a cake or stick of solid vaseline.
counter-irritants and essential oils and the vapors of the alcohol along with the vapors of the counter-irritantsand essential oils produces an extremely potent odor and vapor which appears to have very beneficial results intthe treatment of colds exceeding those attained using comparative amounts of these ingredients in a petrolatum base, the effect of the latter base tending to retard the vaporizing eifect of the ingredients.
In addition to the use of the present preparation as an effective rub and penetrant, and in addition to its use as an inhalant alone or as a combined inhalant and rub, the present preparation possesses characteristics which render its use valuable as a liniment in the treatment of mild pains such as neuralgia and in the treatment of sprains and the like,.and upon application and rubbing into the affected part, the alcoholic solution of the counter-irritants and essential oils penetrates well and offers substantial relief to the ailment.
While it is preferred to produce a medicinal preparation embodying menthol and camphor and the essential oils. is is to be understood that not only may the foregoing proportions be varied, but also forsome purposes the essential oils may be omitted and also either the menthol or the camphor may be omitted, producing preparations having substantial utility in the treatment of colds, congestion in the chest and throat, and for affording relief to many mild pains. I
While the preferred embodiment of the invention has. been herein illustrated and described, it will be understood that the invention may be embodied in other forms within the scope of the following claims.
Having thus described the invention, what is claimed is:
l. A medicinal preparation for application to the skin as a penetrant and also for use as an inhalant, comprising an alcoholic solution of a soap in solidified form having dissolved therein a counter-irritant and menthol, and capable of liquification upon application to the skin under the influence of body heat to thereby deposit thereon a film.
2. A medicinal preparation for application to the skin as a penetrant and also useful as an inhalant comprising an alcoholic solution of a soap in solidified form having dissolved therein camphor, menthol, oil of turpentine, oil of eucalyptus and oil of thyme, and capable of liquification upon application to the skin under the infiuence of body heat to thereby deposit thereon a 3. A medicinal preparation for application to the skin as a penetrant and also useful as an inhalant, said preparation comprising an alcoholic solution of a soap in solidified form having dissolved therein an inhalant and a counter-irritant, said base possessing fixative properties for retarding rapid dissipation of the vapors emitted therefrom.
WILLIAM E. WELCH.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US711065A US2001046A (en) | 1934-02-13 | 1934-02-13 | Medicinal preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US711065A US2001046A (en) | 1934-02-13 | 1934-02-13 | Medicinal preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US2001046A true US2001046A (en) | 1935-05-14 |
Family
ID=24856644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US711065A Expired - Lifetime US2001046A (en) | 1934-02-13 | 1934-02-13 | Medicinal preparation |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US2001046A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2465470A (en) * | 1947-01-11 | 1949-03-29 | Mckesson & Robbins Inc | Insect repellent stick |
| US2724157A (en) * | 1952-05-24 | 1955-11-22 | Sr Waldo I Parks | Vaporizer |
| US2933431A (en) * | 1957-03-28 | 1960-04-19 | Theodore H J Sperouleas | Medicated tissue |
| US4069345A (en) * | 1973-08-22 | 1978-01-17 | Wilkinson Sword Limited | Compositions having a physiological cooling effect |
| US4070449A (en) * | 1972-10-24 | 1978-01-24 | Wilkinson Sword Limited | Compounds having a physiological cooling effect and compositions containing them |
| US4136163A (en) * | 1971-02-04 | 1979-01-23 | Wilkinson Sword Limited | P-menthane carboxamides having a physiological cooling effect |
| US4248859A (en) * | 1973-12-12 | 1981-02-03 | Wilkinson Sword Limited | Alicyclic amides having a physiological cooling effect |
| US4458810A (en) * | 1983-03-18 | 1984-07-10 | Pamela Mahoney | Package of scent impregnated tissues |
-
1934
- 1934-02-13 US US711065A patent/US2001046A/en not_active Expired - Lifetime
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2465470A (en) * | 1947-01-11 | 1949-03-29 | Mckesson & Robbins Inc | Insect repellent stick |
| US2724157A (en) * | 1952-05-24 | 1955-11-22 | Sr Waldo I Parks | Vaporizer |
| US2933431A (en) * | 1957-03-28 | 1960-04-19 | Theodore H J Sperouleas | Medicated tissue |
| US4136163A (en) * | 1971-02-04 | 1979-01-23 | Wilkinson Sword Limited | P-menthane carboxamides having a physiological cooling effect |
| US4070449A (en) * | 1972-10-24 | 1978-01-24 | Wilkinson Sword Limited | Compounds having a physiological cooling effect and compositions containing them |
| US4069345A (en) * | 1973-08-22 | 1978-01-17 | Wilkinson Sword Limited | Compositions having a physiological cooling effect |
| US4248859A (en) * | 1973-12-12 | 1981-02-03 | Wilkinson Sword Limited | Alicyclic amides having a physiological cooling effect |
| US4318900A (en) * | 1973-12-12 | 1982-03-09 | Wilkinson Sword Limited | Alicyclic amides having a physiological cooling effect |
| US4458810A (en) * | 1983-03-18 | 1984-07-10 | Pamela Mahoney | Package of scent impregnated tissues |
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